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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:OAZ1-GAPDH (FusionGDB2 ID:60886)

Fusion Gene Summary for OAZ1-GAPDH

Fusion gene summary

Fusion gene information	Fusion gene name: OAZ1-GAPDH
	Fusion gene ID: 60886
		Hgene	Tgene
	Gene symbol	OAZ1	GAPDH
	Gene ID	4946	2597
	Gene name	ornithine decarboxylase antizyme 1	glyceraldehyde-3-phosphate dehydrogenase
	Synonyms	AZ1\|AZI\|OAZ	G3PD\|GAPD\|HEL-S-162eP
	Cytomap	19p13.3	12p13.31
	Type of gene	protein-coding	protein-coding
	Description	ornithine decarboxylase antizyme 1ODC-Azantizyme 1	glyceraldehyde-3-phosphate dehydrogenaseOCAS, p38 componentOct1 coactivator in S phase, 38 Kd componentaging-associated gene 9 proteinepididymis secretory sperm binding protein Li 162ePpeptidyl-cysteine S-nitrosylase GAPDH
	Modification date	20200313	20200327
	UniProtAcc	.	P04406
	Ensembl transtripts involved in fusion gene	ENST00000582888, ENST00000602676, ENST00000322297, ENST00000583542, ENST00000588673,	ENST00000229239, ENST00000396856, ENST00000396861, ENST00000396859, ENST00000396858,
Fusion gene scores	* DoF score	19 X 7 X 8=1064	27 X 29 X 8=6264
	# samples	17	31
	** MAII score	log2(17/1064*10)=-2.64589149936349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(31/6264*10)=-4.3367440920168 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: OAZ1 [Title/Abstract] AND GAPDH [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	OAZ1(2269743)-GAPDH(6645660), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	OAZ1	GO:0045732	positive regulation of protein catabolic process	17900240
Tgene	GAPDH	GO:0010951	negative regulation of endopeptidase activity	22832495
Tgene	GAPDH	GO:0017148	negative regulation of translation	23071094
Tgene	GAPDH	GO:0031640	killing of cells of other organism	22832495
Tgene	GAPDH	GO:0050715	positive regulation of cytokine secretion	22832495
Tgene	GAPDH	GO:0050832	defense response to fungus	22832495
Tgene	GAPDH	GO:0051873	killing by host of symbiont cells	22832495
Tgene	GAPDH	GO:0052501	positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction	22832495
Tgene	GAPDH	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	22832495
Tgene	GAPDH	GO:0071346	cellular response to interferon-gamma	15479637

Fusion gene breakpoints across OAZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GAPDH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	ERR315469	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+

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Fusion Gene ORF analysis for OAZ1-GAPDH

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000582888	ENST00000229239	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000582888	ENST00000396856	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000582888	ENST00000396861	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000582888	ENST00000396859	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000582888	ENST00000396858	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
In-frame	ENST00000602676	ENST00000229239	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000602676	ENST00000396856	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000602676	ENST00000396861	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000602676	ENST00000396859	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000602676	ENST00000396858	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
In-frame	ENST00000322297	ENST00000229239	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000322297	ENST00000396856	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000322297	ENST00000396861	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000322297	ENST00000396859	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000322297	ENST00000396858	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
In-frame	ENST00000583542	ENST00000229239	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000583542	ENST00000396856	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000583542	ENST00000396861	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000583542	ENST00000396859	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
5CDS-5UTR	ENST00000583542	ENST00000396858	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
intron-3CDS	ENST00000588673	ENST00000229239	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
intron-5UTR	ENST00000588673	ENST00000396856	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
intron-5UTR	ENST00000588673	ENST00000396861	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
intron-5UTR	ENST00000588673	ENST00000396859	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+
intron-5UTR	ENST00000588673	ENST00000396858	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000582888

OAZ1

chr19

2269743

ENST00000229239

GAPDH

chr12

6645660

1439

259

1237

382

ENST00000602676

OAZ1

chr19

2269743

ENST00000229239

GAPDH

chr12

6645660

1405

225

1203

382

ENST00000322297

OAZ1

chr19

2269743

ENST00000229239

GAPDH

chr12

6645660

1404

224

1202

382

ENST00000583542

OAZ1

chr19

2269743

ENST00000229239

GAPDH

chr12

6645660

1400

220

1198

382

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000582888	ENST00000229239	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+	0.002041881	0.99795806
ENST00000602676	ENST00000229239	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+	0.002126855	0.9978732
ENST00000322297	ENST00000229239	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+	0.002117539	0.9978824
ENST00000583542	ENST00000229239	OAZ1	chr19	2269743	+	GAPDH	chr12	6645660	+	0.002193613	0.9978064

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Fusion Genomic Features for OAZ1-GAPDH

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
OAZ1	chr19	2269743	+	GAPDH	chr12	6645659	+	4.91E-07	0.9999995
OAZ1	chr19	2269743	+	GAPDH	chr12	6645659	+	4.91E-07	0.9999995

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for OAZ1-GAPDH

Go to
FGviewer for the breakpoints of chr19:2269743-chr12:6645660
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	GAPDH P04406
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. {ECO:0000250, ECO:0000269\|PubMed:11724794, ECO:0000269\|PubMed:23071094, ECO:0000269\|PubMed:3170585}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000229239

245_250

9.666666666666666

336.0

Motif

[IL]-x-C-x-x-[DE] motif

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000396858

245_250

294.0

Motif

[IL]-x-C-x-x-[DE] motif

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000396859

245_250

9.666666666666666

336.0

Motif

[IL]-x-C-x-x-[DE] motif

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000396861

245_250

9.666666666666666

336.0

Motif

[IL]-x-C-x-x-[DE] motif

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000229239

13_14

9.666666666666666

336.0

Nucleotide binding

NAD

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000396858

13_14

294.0

Nucleotide binding

NAD

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000396859

13_14

9.666666666666666

336.0

Nucleotide binding

NAD

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000396861

13_14

9.666666666666666

336.0

Nucleotide binding

NAD

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000229239

151_153

9.666666666666666

336.0

Region

Glyceraldehyde 3-phosphate binding

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000229239

211_212

9.666666666666666

336.0

Region

Glyceraldehyde 3-phosphate binding

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000396858

151_153

294.0

Region

Glyceraldehyde 3-phosphate binding

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000396858

211_212

294.0

Region

Glyceraldehyde 3-phosphate binding

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000396859

151_153

9.666666666666666

336.0

Region

Glyceraldehyde 3-phosphate binding

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000396859

211_212

9.666666666666666

336.0

Region

Glyceraldehyde 3-phosphate binding

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000396861

151_153

9.666666666666666

336.0

Region

Glyceraldehyde 3-phosphate binding

Tgene

GAPDH

chr19:2269743

chr12:6645660

ENST00000396861

211_212

9.666666666666666

336.0

Region

Glyceraldehyde 3-phosphate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for OAZ1-GAPDH

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000582888_ENST00000229239_ERR315469_OAZ1_chr19_2269743_+_GAPDH_chr12_6645660_length(transcript)=1439nt_BP=259nt
AGCATCTATAAAGGCGGGCGGCGGCAGAGGCGCCATTTTGCGAACGGCGAGCAGCGGCGGCGGCGCGGAGAGACGCAGCGGAGGTTTTCC
TGGTTTCGGACCCCAGCGGCCGGATGGTGAAATCCTCCCTGCAGCGGATCCTCAATAGCCACTGCTTCGCCAGAGAGAAGGAAGGGGATA
AACCCAGCGCCACCATCCACGCCAGCCGCACCATGCCGCTCCTAAGCCTGCACAGCCGCGGCGGCAGCAGCAGTGAGAGATTTGGTCGTA
TTGGGCGCCTGGTCACCAGGGCTGCTTTTAACTCTGGTAAAGTGGATATTGTTGCCATCAATGACCCCTTCATTGACCTCAACTACATGG
TTTACATGTTCCAATATGATTCCACCCATGGCAAATTCCATGGCACCGTCAAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCA
TCACCATCTTCCAGGAGCGAGATCCCTCCAAAATCAAGTGGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGGCGTCTTCACCA
CCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGAGCCAAAAGGGTCATCATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGG
GTGTGAACCATGAGAAGTATGACAACAGCCTCAAGATCATCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTGGCCAAGGTCA
TCCATGACAACTTTGGTATCGTGGAAGGACTCATGACCACAGTCCATGCCATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGA
AACTGTGGCGTGATGGCCGCGGGGCTCTCCAGAACATCATCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGTCATCCCTGAGC
TGAACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCCACTGCCAACGTGTCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCA
AATATGATGACATCAAGAAGGTGGTGAAGCAGGCGTCGGAGGGCCCCCTCAAGGGCATCCTGGGCTACACTGAGCACCAGGTGGTCTCCT
CTGACTTCAACAGCGACACCCACTCCTCCACCTTTGACGCTGGGGCTGGCATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGT
ATGACAACGAATTTGGCTACAGCAACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGAGTAAGACCCCTGGACCACCAGCCCCA
GCAAGAGCACAAGAGGAAGAGAGAGACCCTCACTGCTGGGGAGTCCCTGCCACACTCAGTCCCCCACCACACTGAATCTCCCCTCCTCAC

>In-frame_ENST00000582888_ENST00000229239_ERR315469_OAZ1_chr19_2269743_+_GAPDH_chr12_6645660_length(amino acids)=382AA_start in transcript=89_stop in transcript=1237
MVSDPSGRMVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGGSSSERFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYM
VYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVM
GVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPE
LNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISW

--------------------------------------------------------------
>In-frame_ENST00000602676_ENST00000229239_ERR315469_OAZ1_chr19_2269743_+_GAPDH_chr12_6645660_length(transcript)=1405nt_BP=225nt
ATTTTGCGAACGGCGAGCAGCGGCGGCGGCGCGGAGAGACGCAGCGGAGGTTTTCCTGGTTTCGGACCCCAGCGGCCGGATGGTGAAATC
CTCCCTGCAGCGGATCCTCAATAGCCACTGCTTCGCCAGAGAGAAGGAAGGGGATAAACCCAGCGCCACCATCCACGCCAGCCGCACCAT
GCCGCTCCTAAGCCTGCACAGCCGCGGCGGCAGCAGCAGTGAGAGATTTGGTCGTATTGGGCGCCTGGTCACCAGGGCTGCTTTTAACTC
TGGTAAAGTGGATATTGTTGCCATCAATGACCCCTTCATTGACCTCAACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAA
ATTCCATGGCACCGTCAAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCGAGATCCCTCCAAAAT
CAAGTGGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGGCGTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGG
AGCCAAAAGGGTCATCATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTATGACAACAGCCTCAA
GATCATCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTGGCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCAT
GACCACAGTCCATGCCATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGCGGGGCTCTCCAGAA
CATCATCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGTCATCCCTGAGCTGAACGGGAAGCTCACTGGCATGGCCTTCCGTGT
CCCCACTGCCAACGTGTCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAGGTGGTGAAGCAGGC
GTCGGAGGGCCCCCTCAAGGGCATCCTGGGCTACACTGAGCACCAGGTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTT
TGACGCTGGGGCTGGCATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTACAGCAACAGGGTGGT
GGACCTCATGGCCCACATGGCCTCCAAGGAGTAAGACCCCTGGACCACCAGCCCCAGCAAGAGCACAAGAGGAAGAGAGAGACCCTCACT
GCTGGGGAGTCCCTGCCACACTCAGTCCCCCACCACACTGAATCTCCCCTCCTCACAGTTGCCATGTAGACCCCTTGAAGAGGGGAGGGG

>In-frame_ENST00000602676_ENST00000229239_ERR315469_OAZ1_chr19_2269743_+_GAPDH_chr12_6645660_length(amino acids)=382AA_start in transcript=55_stop in transcript=1203
MVSDPSGRMVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGGSSSERFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYM
VYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVM
GVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPE
LNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISW

--------------------------------------------------------------
>In-frame_ENST00000322297_ENST00000229239_ERR315469_OAZ1_chr19_2269743_+_GAPDH_chr12_6645660_length(transcript)=1404nt_BP=224nt
TTTTGCGAACGGCGAGCAGCGGCGGCGGCGCGGAGAGACGCAGCGGAGGTTTTCCTGGTTTCGGACCCCAGCGGCCGGATGGTGAAATCC
TCCCTGCAGCGGATCCTCAATAGCCACTGCTTCGCCAGAGAGAAGGAAGGGGATAAACCCAGCGCCACCATCCACGCCAGCCGCACCATG
CCGCTCCTAAGCCTGCACAGCCGCGGCGGCAGCAGCAGTGAGAGATTTGGTCGTATTGGGCGCCTGGTCACCAGGGCTGCTTTTAACTCT
GGTAAAGTGGATATTGTTGCCATCAATGACCCCTTCATTGACCTCAACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAAA
TTCCATGGCACCGTCAAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCGAGATCCCTCCAAAATC
AAGTGGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGGCGTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGA
GCCAAAAGGGTCATCATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTATGACAACAGCCTCAAG
ATCATCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTGGCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCATG
ACCACAGTCCATGCCATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGCGGGGCTCTCCAGAAC
ATCATCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGTCATCCCTGAGCTGAACGGGAAGCTCACTGGCATGGCCTTCCGTGTC
CCCACTGCCAACGTGTCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAGGTGGTGAAGCAGGCG
TCGGAGGGCCCCCTCAAGGGCATCCTGGGCTACACTGAGCACCAGGTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTT
GACGCTGGGGCTGGCATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTACAGCAACAGGGTGGTG
GACCTCATGGCCCACATGGCCTCCAAGGAGTAAGACCCCTGGACCACCAGCCCCAGCAAGAGCACAAGAGGAAGAGAGAGACCCTCACTG
CTGGGGAGTCCCTGCCACACTCAGTCCCCCACCACACTGAATCTCCCCTCCTCACAGTTGCCATGTAGACCCCTTGAAGAGGGGAGGGGC

>In-frame_ENST00000322297_ENST00000229239_ERR315469_OAZ1_chr19_2269743_+_GAPDH_chr12_6645660_length(amino acids)=382AA_start in transcript=54_stop in transcript=1202
MVSDPSGRMVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGGSSSERFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYM
VYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVM
GVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPE
LNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISW

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>In-frame_ENST00000583542_ENST00000229239_ERR315469_OAZ1_chr19_2269743_+_GAPDH_chr12_6645660_length(transcript)=1400nt_BP=220nt
GCGAACGGCGAGCAGCGGCGGCGGCGCGGAGAGACGCAGCGGAGGTTTTCCTGGTTTCGGACCCCAGCGGCCGGATGGTGAAATCCTCCC
TGCAGCGGATCCTCAATAGCCACTGCTTCGCCAGAGAGAAGGAAGGGGATAAACCCAGCGCCACCATCCACGCCAGCCGCACCATGCCGC
TCCTAAGCCTGCACAGCCGCGGCGGCAGCAGCAGTGAGAGATTTGGTCGTATTGGGCGCCTGGTCACCAGGGCTGCTTTTAACTCTGGTA
AAGTGGATATTGTTGCCATCAATGACCCCTTCATTGACCTCAACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAAATTCC
ATGGCACCGTCAAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCGAGATCCCTCCAAAATCAAGT
GGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGGCGTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGAGCCA
AAAGGGTCATCATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTATGACAACAGCCTCAAGATCA
TCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTGGCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCATGACCA
CAGTCCATGCCATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGCGGGGCTCTCCAGAACATCA
TCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGTCATCCCTGAGCTGAACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCCA
CTGCCAACGTGTCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAGGTGGTGAAGCAGGCGTCGG
AGGGCCCCCTCAAGGGCATCCTGGGCTACACTGAGCACCAGGTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTTGACG
CTGGGGCTGGCATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTACAGCAACAGGGTGGTGGACC
TCATGGCCCACATGGCCTCCAAGGAGTAAGACCCCTGGACCACCAGCCCCAGCAAGAGCACAAGAGGAAGAGAGAGACCCTCACTGCTGG
GGAGTCCCTGCCACACTCAGTCCCCCACCACACTGAATCTCCCCTCCTCACAGTTGCCATGTAGACCCCTTGAAGAGGGGAGGGGCCTAG

>In-frame_ENST00000583542_ENST00000229239_ERR315469_OAZ1_chr19_2269743_+_GAPDH_chr12_6645660_length(amino acids)=382AA_start in transcript=50_stop in transcript=1198
MVSDPSGRMVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGGSSSERFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYM
VYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVM
GVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPE
LNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISW

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Fusion Gene PPI Analysis for OAZ1-GAPDH

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	GAPDH	chr19:2269743	chr12:6645660	ENST00000396858		0	8	2_148	0	294.0	WARS1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	GAPDH	chr19:2269743	chr12:6645660	ENST00000229239		1	9	2_148	9.666666666666666	336.0	WARS1
Tgene	GAPDH	chr19:2269743	chr12:6645660	ENST00000396859		0	8	2_148	9.666666666666666	336.0	WARS1
Tgene	GAPDH	chr19:2269743	chr12:6645660	ENST00000396861		1	9	2_148	9.666666666666666	336.0	WARS1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for OAZ1-GAPDH

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	GAPDH	P04406	DB09130	Copper		Small molecule	Approved\|Investigational
Tgene	GAPDH	P04406	DB09130	Copper		Small molecule	Approved\|Investigational
Tgene	GAPDH	P04406	DB09130	Copper		Small molecule	Approved\|Investigational
Tgene	GAPDH	P04406	DB09130	Copper		Small molecule	Approved\|Investigational
Tgene	GAPDH	P04406	DB00157	NADH		Small molecule	Approved\|Nutraceutical
Tgene	GAPDH	P04406	DB00157	NADH		Small molecule	Approved\|Nutraceutical
Tgene	GAPDH	P04406	DB00157	NADH		Small molecule	Approved\|Nutraceutical
Tgene	GAPDH	P04406	DB00157	NADH		Small molecule	Approved\|Nutraceutical
Tgene	GAPDH	P04406	DB09092	Xanthinol	Cofactor	Small molecule	Approved\|Withdrawn
Tgene	GAPDH	P04406	DB09092	Xanthinol	Cofactor	Small molecule	Approved\|Withdrawn
Tgene	GAPDH	P04406	DB09092	Xanthinol	Cofactor	Small molecule	Approved\|Withdrawn
Tgene	GAPDH	P04406	DB09092	Xanthinol	Cofactor	Small molecule	Approved\|Withdrawn

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Related Diseases for OAZ1-GAPDH

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	GAPDH	C2239176	Liver carcinoma	2	CTD_human
Tgene	GAPDH	C0001787	Osteoporosis, Age-Related	1	CTD_human
Tgene	GAPDH	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Tgene	GAPDH	C0003129	Anoxemia	1	CTD_human
Tgene	GAPDH	C0003130	Anoxia	1	CTD_human
Tgene	GAPDH	C0007137	Squamous cell carcinoma	1	CTD_human
Tgene	GAPDH	C0009402	Colorectal Carcinoma	1	CTD_human
Tgene	GAPDH	C0009404	Colorectal Neoplasms	1	CTD_human
Tgene	GAPDH	C0014859	Esophageal Neoplasms	1	CTD_human
Tgene	GAPDH	C0026640	Mouth Neoplasms	1	CTD_human
Tgene	GAPDH	C0027540	Necrosis	1	CTD_human
Tgene	GAPDH	C0029408	Degenerative polyarthritis	1	CTD_human
Tgene	GAPDH	C0029456	Osteoporosis	1	CTD_human
Tgene	GAPDH	C0029459	Osteoporosis, Senile	1	CTD_human
Tgene	GAPDH	C0086743	Osteoarthrosis Deformans	1	CTD_human
Tgene	GAPDH	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Tgene	GAPDH	C0153381	Malignant neoplasm of mouth	1	CTD_human
Tgene	GAPDH	C0242184	Hypoxia	1	CTD_human
Tgene	GAPDH	C0546837	Malignant neoplasm of esophagus	1	CTD_human
Tgene	GAPDH	C0700292	Hypoxemia	1	CTD_human
Tgene	GAPDH	C0751406	Post-Traumatic Osteoporosis	1	CTD_human
Tgene	GAPDH	C0948089	Acute Coronary Syndrome	1	CTD_human