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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OBSCN-CASZ1 (FusionGDB2 ID:60912)

Fusion Gene Summary for OBSCN-CASZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: OBSCN-CASZ1
Fusion gene ID: 60912
HgeneTgene
Gene symbol

OBSCN

CASZ1

Gene ID

84033

54897

Gene nameobscurin, cytoskeletal calmodulin and titin-interacting RhoGEFcastor zinc finger 1
SynonymsARHGEF30|UNC89CAS11|CST|SRG|ZNF693|dJ734G22.1
Cytomap

1q42.13

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionobscurinobscurin, myosin light chain kinaseobscurin-MLCKzinc finger protein castor homolog 1castor homolog 1, zinc fingercastor-related proteinsurvival-relatedzinc finger protein 693
Modification date2020031320200313
UniProtAcc.

Q86V15

Ensembl transtripts involved in fusion geneENST00000284548, ENST00000570156, 
ENST00000366709, ENST00000422127, 
ENST00000366707, ENST00000359599, 
ENST00000602685, 		ENST00000377022, 
ENST00000344008, ENST00000478728, 
Fusion gene scores* DoF score6 X 8 X 3=1446 X 7 X 5=210
# samples 67
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OBSCN [Title/Abstract] AND CASZ1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOBSCN(228412435)-CASZ1(10725628), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCASZ1

GO:0045893

positive regulation of transcription, DNA-templated

27693370


check buttonFusion gene breakpoints across OBSCN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CASZ1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BB-4223-01AOBSCNchr1

228412435

+CASZ1chr1

10725628

-
ChimerDB4HNSCTCGA-BB-4223OBSCNchr1

228412435

+CASZ1chr1

10725628

-
ChimerDB4HNSCTCGA-BB-4223OBSCNchr1

228412435

+CASZ1chr1

10725628

-
ChimerDB4HNSCTCGA-BB-4223OBSCNchr1

228412435

+CASZ1chr1

10725628

-
ChimerDB4HNSCTCGA-BB-4223-01AOBSCNchr1

228412435

-CASZ1chr1

10725628

-


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Fusion Gene ORF analysis for OBSCN-CASZ1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000284548ENST00000377022OBSCNchr1

228412435

+CASZ1chr1

10725628

-
In-frameENST00000284548ENST00000344008OBSCNchr1

228412435

+CASZ1chr1

10725628

-
5CDS-5UTRENST00000284548ENST00000478728OBSCNchr1

228412435

+CASZ1chr1

10725628

-
In-frameENST00000570156ENST00000377022OBSCNchr1

228412435

+CASZ1chr1

10725628

-
In-frameENST00000570156ENST00000344008OBSCNchr1

228412435

+CASZ1chr1

10725628

-
5CDS-5UTRENST00000570156ENST00000478728OBSCNchr1

228412435

+CASZ1chr1

10725628

-
5UTR-3CDSENST00000366709ENST00000377022OBSCNchr1

228412435

+CASZ1chr1

10725628

-
5UTR-3CDSENST00000366709ENST00000344008OBSCNchr1

228412435

+CASZ1chr1

10725628

-
5UTR-5UTRENST00000366709ENST00000478728OBSCNchr1

228412435

+CASZ1chr1

10725628

-
In-frameENST00000422127ENST00000377022OBSCNchr1

228412435

+CASZ1chr1

10725628

-
In-frameENST00000422127ENST00000344008OBSCNchr1

228412435

+CASZ1chr1

10725628

-
5CDS-5UTRENST00000422127ENST00000478728OBSCNchr1

228412435

+CASZ1chr1

10725628

-
5UTR-3CDSENST00000366707ENST00000377022OBSCNchr1

228412435

+CASZ1chr1

10725628

-
5UTR-3CDSENST00000366707ENST00000344008OBSCNchr1

228412435

+CASZ1chr1

10725628

-
5UTR-5UTRENST00000366707ENST00000478728OBSCNchr1

228412435

+CASZ1chr1

10725628

-
intron-3CDSENST00000359599ENST00000377022OBSCNchr1

228412435

+CASZ1chr1

10725628

-
intron-3CDSENST00000359599ENST00000344008OBSCNchr1

228412435

+CASZ1chr1

10725628

-
intron-5UTRENST00000359599ENST00000478728OBSCNchr1

228412435

+CASZ1chr1

10725628

-
intron-3CDSENST00000602685ENST00000377022OBSCNchr1

228412435

+CASZ1chr1

10725628

-
intron-3CDSENST00000602685ENST00000344008OBSCNchr1

228412435

+CASZ1chr1

10725628

-
intron-5UTRENST00000602685ENST00000478728OBSCNchr1

228412435

+CASZ1chr1

10725628

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000284548OBSCNchr1228412435+ENST00000377022CASZ1chr110725628-1060530037482662730
ENST00000284548OBSCNchr1228412435+ENST00000344008CASZ1chr110725628-707230037464872137
ENST00000570156OBSCNchr1228412435+ENST00000377022CASZ1chr110725628-1088132797485422822
ENST00000570156OBSCNchr1228412435+ENST00000344008CASZ1chr110725628-734832797467632229
ENST00000422127OBSCNchr1228412435+ENST00000377022CASZ1chr110725628-1057529734482362730
ENST00000422127OBSCNchr1228412435+ENST00000344008CASZ1chr110725628-704229734464572137

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000284548ENST00000377022OBSCNchr1228412435+CASZ1chr110725628-0.0028990620.9971009
ENST00000284548ENST00000344008OBSCNchr1228412435+CASZ1chr110725628-0.0035406020.9964594
ENST00000570156ENST00000377022OBSCNchr1228412435+CASZ1chr110725628-0.0029054290.9970945
ENST00000570156ENST00000344008OBSCNchr1228412435+CASZ1chr110725628-0.0035155870.9964844
ENST00000422127ENST00000377022OBSCNchr1228412435+CASZ1chr110725628-0.0028375930.9971624
ENST00000422127ENST00000344008OBSCNchr1228412435+CASZ1chr110725628-0.003459880.9965402

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Fusion Genomic Features for OBSCN-CASZ1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for OBSCN-CASZ1


check button Go to

FGviewer for the breakpoints of chr1:228412435-chr1:10725628

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CASZ1

Q86V15

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981192_198976.33333333333346621.0Compositional biasNote=Poly-Ala
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981710_713976.33333333333346621.0Compositional biasNote=Poly-Ala
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981931_934976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105192_198976.33333333333347969.0Compositional biasNote=Poly-Ala
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105710_713976.33333333333347969.0Compositional biasNote=Poly-Ala
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105931_934976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+98110_100976.33333333333346621.0DomainNote=Ig-like 1
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981110_202976.33333333333346621.0DomainNote=Ig-like 2
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981236_322976.33333333333346621.0DomainNote=Ig-like 3
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981331_414976.33333333333346621.0DomainNote=Ig-like 4
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981420_508976.33333333333346621.0DomainNote=Ig-like 5
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981515_612976.33333333333346621.0DomainFibronectin type-III 1
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981619_698976.33333333333346621.0DomainNote=Ig-like 6
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981701_790976.33333333333346621.0DomainNote=Ig-like 7
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981798_884976.33333333333346621.0DomainNote=Ig-like 8
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981886_977976.33333333333346621.0DomainNote=Ig-like 9
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+910510_100976.33333333333347969.0DomainNote=Ig-like 1
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105110_202976.33333333333347969.0DomainNote=Ig-like 2
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105236_322976.33333333333347969.0DomainNote=Ig-like 3
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105331_414976.33333333333347969.0DomainNote=Ig-like 4
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105420_508976.33333333333347969.0DomainNote=Ig-like 5
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105515_612976.33333333333347969.0DomainFibronectin type-III 1
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105619_698976.33333333333347969.0DomainNote=Ig-like 6
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105701_790976.33333333333347969.0DomainNote=Ig-like 7
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105798_884976.33333333333347969.0DomainNote=Ig-like 8
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105886_977976.33333333333347969.0DomainNote=Ig-like 9
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161080_11435.3333333333333331167.0Compositional biasNote=Pro-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161635_16705.3333333333333331167.0Compositional biasNote=Ala-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161672_17295.3333333333333331167.0Compositional biasNote=Glu-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161691_17185.3333333333333331167.0Compositional biasNote=Asp-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST00000344008316384_4175.3333333333333331167.0Compositional biasNote=Pro-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211080_11435.3333333333333331760.0Compositional biasNote=Pro-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211635_16705.3333333333333331760.0Compositional biasNote=Ala-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211672_17295.3333333333333331760.0Compositional biasNote=Glu-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211691_17185.3333333333333331760.0Compositional biasNote=Asp-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST00000377022321384_4175.3333333333333331760.0Compositional biasNote=Pro-rich
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161031_10555.3333333333333331167.0Zinc fingerC2H2-type 4
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161300_13245.3333333333333331167.0Zinc fingerC2H2-type 5
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161457_14815.3333333333333331167.0Zinc fingerC2H2-type 6
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161515_15375.3333333333333331167.0Zinc fingerC2H2-type 7
TgeneCASZ1chr1:228412435chr1:10725628ENST000003440083161571_15955.3333333333333331167.0Zinc fingerC2H2-type 8
TgeneCASZ1chr1:228412435chr1:10725628ENST00000344008316551_5755.3333333333333331167.0Zinc fingerC2H2-type 1
TgeneCASZ1chr1:228412435chr1:10725628ENST00000344008316610_6345.3333333333333331167.0Zinc fingerC2H2-type 2
TgeneCASZ1chr1:228412435chr1:10725628ENST00000344008316668_6925.3333333333333331167.0Zinc fingerC2H2-type 3
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211031_10555.3333333333333331760.0Zinc fingerC2H2-type 4
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211300_13245.3333333333333331760.0Zinc fingerC2H2-type 5
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211457_14815.3333333333333331760.0Zinc fingerC2H2-type 6
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211515_15375.3333333333333331760.0Zinc fingerC2H2-type 7
TgeneCASZ1chr1:228412435chr1:10725628ENST000003770223211571_15955.3333333333333331760.0Zinc fingerC2H2-type 8
TgeneCASZ1chr1:228412435chr1:10725628ENST00000377022321551_5755.3333333333333331760.0Zinc fingerC2H2-type 1
TgeneCASZ1chr1:228412435chr1:10725628ENST00000377022321610_6345.3333333333333331760.0Zinc fingerC2H2-type 2
TgeneCASZ1chr1:228412435chr1:10725628ENST00000377022321668_6925.3333333333333331760.0Zinc fingerC2H2-type 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811115_1118976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811207_1210976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811299_1302976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811391_1394976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811575_1578976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811667_1670976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814398_4401976.33333333333346621.0Compositional biasNote=Poly-Leu
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814846_4849976.33333333333346621.0Compositional biasNote=Poly-Gln
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816789_6796976.33333333333346621.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816969_7117976.33333333333346621.0Compositional biasNote=Pro-rich
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051115_1118976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051207_1210976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051299_1302976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051391_1394976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051575_1578976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051667_1670976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054398_4401976.33333333333347969.0Compositional biasNote=Poly-Leu
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054846_4849976.33333333333347969.0Compositional biasNote=Poly-Gln
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056789_6796976.33333333333347969.0Compositional biasNote=Poly-Ser
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056969_7117976.33333333333347969.0Compositional biasNote=Pro-rich
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811070_1161976.33333333333346621.0DomainNote=Ig-like 11
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811162_1252976.33333333333346621.0DomainNote=Ig-like 12
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811254_1345976.33333333333346621.0DomainNote=Ig-like 13
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811346_1432976.33333333333346621.0DomainNote=Ig-like 14
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811438_1524976.33333333333346621.0DomainNote=Ig-like 15
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811530_1621976.33333333333346621.0DomainNote=Ig-like 16
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811622_1719976.33333333333346621.0DomainNote=Ig-like 17
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811731_1808976.33333333333346621.0DomainFibronectin type-III 2
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811809_1894976.33333333333346621.0DomainNote=Ig-like 18
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811896_1982976.33333333333346621.0DomainNote=Ig-like 19
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9811987_2071976.33333333333346621.0DomainNote=Ig-like 20
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812077_2162976.33333333333346621.0DomainNote=Ig-like 21
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812165_2249976.33333333333346621.0DomainNote=Ig-like 22
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812289_2380976.33333333333346621.0DomainNote=Ig-like 23
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812468_2559976.33333333333346621.0DomainNote=Ig-like 24
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812564_2643976.33333333333346621.0DomainNote=Ig-like 25
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812646_2730976.33333333333346621.0DomainNote=Ig-like 26
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812736_2823976.33333333333346621.0DomainNote=Ig-like 27
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812826_2908976.33333333333346621.0DomainNote=Ig-like 28
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9812920_2999976.33333333333346621.0DomainNote=Ig-like 29
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813003_3092976.33333333333346621.0DomainNote=Ig-like 30
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813095_3183976.33333333333346621.0DomainNote=Ig-like 31
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813184_3268976.33333333333346621.0DomainNote=Ig-like 32
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813273_3356976.33333333333346621.0DomainNote=Ig-like 33
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813359_3444976.33333333333346621.0DomainNote=Ig-like 34
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813449_3532976.33333333333346621.0DomainNote=Ig-like 35
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813537_3620976.33333333333346621.0DomainNote=Ig-like 36
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813625_3708976.33333333333346621.0DomainNote=Ig-like 37
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813713_3796976.33333333333346621.0DomainNote=Ig-like 38
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813801_3884976.33333333333346621.0DomainNote=Ig-like 39
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813890_3973976.33333333333346621.0DomainNote=Ig-like 40
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9813978_4062976.33333333333346621.0DomainNote=Ig-like 41
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814068_4160976.33333333333346621.0DomainNote=Ig-like 42
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814171_4239976.33333333333346621.0DomainNote=Ig-like 43
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814248_4337976.33333333333346621.0DomainNote=Ig-like 44
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814340_4427976.33333333333346621.0DomainNote=Ig-like 45
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814430_4518976.33333333333346621.0DomainNote=Ig-like 46
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814525_4619976.33333333333346621.0DomainFibronectin type-III 3
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814624_4714976.33333333333346621.0DomainNote=Ig-like 47
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814872_4901976.33333333333346621.0DomainIQ
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9814898_4989976.33333333333346621.0DomainNote=Ig-like 48
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9815126_5215976.33333333333346621.0DomainNote=Ig-like 49
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9815260_5349976.33333333333346621.0DomainNote=Ig-like 50
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9815371_5467976.33333333333346621.0DomainNote=Ig-like 51
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9815600_5667976.33333333333346621.0DomainSH3
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9815693_5877976.33333333333346621.0DomainDH
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9815895_6004976.33333333333346621.0DomainPH
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816014_6097976.33333333333346621.0DomainNote=Ig-like 52
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816108_6200976.33333333333346621.0DomainNote=Ig-like 53
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816357_6445976.33333333333346621.0DomainNote=Ig-like 54
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816468_6721976.33333333333346621.0DomainProtein kinase 1
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9817463_7552976.33333333333346621.0DomainNote=Ig-like 55
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9817557_7649976.33333333333346621.0DomainFibronectin type-III 4
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9817672_7924976.33333333333346621.0DomainProtein kinase 2
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+981978_1066976.33333333333346621.0DomainNote=Ig-like 10
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051070_1161976.33333333333347969.0DomainNote=Ig-like 11
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051162_1252976.33333333333347969.0DomainNote=Ig-like 12
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051254_1345976.33333333333347969.0DomainNote=Ig-like 13
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051346_1432976.33333333333347969.0DomainNote=Ig-like 14
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051438_1524976.33333333333347969.0DomainNote=Ig-like 15
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051530_1621976.33333333333347969.0DomainNote=Ig-like 16
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051622_1719976.33333333333347969.0DomainNote=Ig-like 17
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051731_1808976.33333333333347969.0DomainFibronectin type-III 2
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051809_1894976.33333333333347969.0DomainNote=Ig-like 18
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051896_1982976.33333333333347969.0DomainNote=Ig-like 19
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91051987_2071976.33333333333347969.0DomainNote=Ig-like 20
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052077_2162976.33333333333347969.0DomainNote=Ig-like 21
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052165_2249976.33333333333347969.0DomainNote=Ig-like 22
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052289_2380976.33333333333347969.0DomainNote=Ig-like 23
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052468_2559976.33333333333347969.0DomainNote=Ig-like 24
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052564_2643976.33333333333347969.0DomainNote=Ig-like 25
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052646_2730976.33333333333347969.0DomainNote=Ig-like 26
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052736_2823976.33333333333347969.0DomainNote=Ig-like 27
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052826_2908976.33333333333347969.0DomainNote=Ig-like 28
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91052920_2999976.33333333333347969.0DomainNote=Ig-like 29
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053003_3092976.33333333333347969.0DomainNote=Ig-like 30
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053095_3183976.33333333333347969.0DomainNote=Ig-like 31
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053184_3268976.33333333333347969.0DomainNote=Ig-like 32
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053273_3356976.33333333333347969.0DomainNote=Ig-like 33
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053359_3444976.33333333333347969.0DomainNote=Ig-like 34
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053449_3532976.33333333333347969.0DomainNote=Ig-like 35
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053537_3620976.33333333333347969.0DomainNote=Ig-like 36
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053625_3708976.33333333333347969.0DomainNote=Ig-like 37
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053713_3796976.33333333333347969.0DomainNote=Ig-like 38
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053801_3884976.33333333333347969.0DomainNote=Ig-like 39
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053890_3973976.33333333333347969.0DomainNote=Ig-like 40
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91053978_4062976.33333333333347969.0DomainNote=Ig-like 41
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054068_4160976.33333333333347969.0DomainNote=Ig-like 42
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054171_4239976.33333333333347969.0DomainNote=Ig-like 43
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054248_4337976.33333333333347969.0DomainNote=Ig-like 44
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054340_4427976.33333333333347969.0DomainNote=Ig-like 45
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054430_4518976.33333333333347969.0DomainNote=Ig-like 46
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054525_4619976.33333333333347969.0DomainFibronectin type-III 3
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054624_4714976.33333333333347969.0DomainNote=Ig-like 47
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054872_4901976.33333333333347969.0DomainIQ
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91054898_4989976.33333333333347969.0DomainNote=Ig-like 48
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91055126_5215976.33333333333347969.0DomainNote=Ig-like 49
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91055260_5349976.33333333333347969.0DomainNote=Ig-like 50
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91055371_5467976.33333333333347969.0DomainNote=Ig-like 51
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91055600_5667976.33333333333347969.0DomainSH3
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91055693_5877976.33333333333347969.0DomainDH
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91055895_6004976.33333333333347969.0DomainPH
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056014_6097976.33333333333347969.0DomainNote=Ig-like 52
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056108_6200976.33333333333347969.0DomainNote=Ig-like 53
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056357_6445976.33333333333347969.0DomainNote=Ig-like 54
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056468_6721976.33333333333347969.0DomainProtein kinase 1
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91057463_7552976.33333333333347969.0DomainNote=Ig-like 55
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91057557_7649976.33333333333347969.0DomainFibronectin type-III 4
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91057672_7924976.33333333333347969.0DomainProtein kinase 2
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+9105978_1066976.33333333333347969.0DomainNote=Ig-like 10
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9816474_6482976.33333333333346621.0Nucleotide bindingATP
HgeneOBSCNchr1:228412435chr1:10725628ENST00000284548+9817678_7686976.33333333333346621.0Nucleotide bindingATP
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91056474_6482976.33333333333347969.0Nucleotide bindingATP
HgeneOBSCNchr1:228412435chr1:10725628ENST00000422127+91057678_7686976.33333333333347969.0Nucleotide bindingATP


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Fusion Gene Sequence for OBSCN-CASZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000284548_ENST00000377022_TCGA-BB-4223-01A_OBSCN_chr1_228412435_+_CASZ1_chr1_10725628_length(transcript)=10605nt_BP=3003nt
TGCCTCCCAGCCTGTGCCCCCAGCCTGCGTGCTGCCCAGAGCCCCCATAGAGAGAGGTCCCCGCCGCCACCCTCATGGATCAGCCACAGT
TCAGCGGGGCGCCCCGCTTTCTCACCCGGCCCAAGGCCTTCGTGGTGTCGGTGGGCAAGGACGCCACCCTCAGCTGCCAGATCGTGGGTA
ATCCCACGCCACAGGTGAGCTGGGAGAAGGACCAGCAGCCGGTGGCGGCCGGCGCGCGCTTCCGTCTGGCCCAGGACGGCGACCTCTACC
GCCTCACTATCCTGGACCTGGCGCTGGGCGACAGTGGGCAATACGTGTGCCGCGCGCGCAATGCCATAGGCGAGGCCTTCGCTGCTGTGG
GCCTGCAGGTGGACGCGGAGGCCGCGTGCGCCGAGCAGGCGCCGCACTTCCTGCTGCGGCCCACGTCCATCCGCGTGCGCGAGGGCTCAG
AGGCCACCTTCCGCTGCCGCGTGGGTGGCTCCCCGAGGCCGGCAGTGAGCTGGTCCAAGGACGGGCGGCGCCTGGGTGAGCCCGACGGCC
CCCGCGTGCGCGTGGAGGAGCTCGGCGAGGCAAGTGCGCTGCGCATTCGGGCGGCGCGGCCGCGCGACGGCGGCACTTACGAGGTCCGCG
CCGAGAACCCGCTGGGCGCTGCCAGCGCCGCCGCGGCGCTAGTGGTGGACTCGGACGCCGCGGACACGGCCAGCCGGCCCGGGACCTCCA
CGGCCGCGCTCCTGGCGCACCTGCAGCGGCGGCGCGAGGCTATGCGCGCCGAGGGCGCCCCCGCCTCACCGCCCAGCACCGGCACGCGCA
CCTGCACGGTGACTGAAGGCAAGCACGCGCGCCTCAGCTGCTACGTGACCGGCGAGCCCAAGCCCGAGACGGTGTGGAAGAAGGACGGCC
AGCTGGTGACCGAGGGCCGGCGCCACGTGGTGTACGAGGACGCGCAGGAGAACTTCGTGCTCAAGATCCTCTTCTGCAAGCAGTCGGACC
GCGGCCTCTACACCTGCACGGCGTCCAACCTCGTGGGCCAGACCTACAGCTCTGTGCTGGTCGTAGTGCGCGAGCCCGCGGTTCCCTTCA
AAAAGCGGCTGCAAGATCTGGAGGTGCGGGAGAAGGAGTCGGCCACGTTCCTATGTGAGGTGCCCCAGCCGTCCACTGAGGCCGCGTGGT
TCAAGGAGGAGACGCGGTTGTGGGCGAGCGCCAAGTACGGCATCGAGGAGGAGGGCACCGAGCGCCGCCTGACCGTGCGCAATGTCTCGG
CCGACGACGACGCGGTGTACATCTGCGAGACGCCAGAGGGCAGCCGCACGGTGGCGGAGCTCGCAGTCCAAGGAAACCTCCTCCGAAAGC
TCCCTCGGAAGACGGCGGTGCGCGTGGGCGACACGGCTATGTTTTGCGTGGAGCTGGCGGTCCCGGTGGGCCCCGTCCACTGGCTGCGGA
ACCAGGAGGAAGTGGTGGCGGGGGGCCGCGTGGCCATCTCCGCGGAGGGCACGCGCCACACACTAACCATCTCCCAGTGCTGCCTGGAGG
ATGTGGGCCAGGTGGCCTTTATGGCTGGCGACTGCCAGACGTCCACCCAGTTCTGCGTGTCGGCCCCCAGGAAGCCTCCCCTGCAACCCC
CTGTGGATCCTGTGGTAAAGGCCAGGATGGAGAGTTCCGTGATTCTCAGCTGGTCCCCACCACCCCATGGGGAACGCCCTGTCACTATCG
ACGGCTACCTGGTAGAGAAGAAGAAGCTTGGCACCTACACCTGGATCAGGTGCCACGAGGCTGAATGGGTGGCTACACCTGAGCTGACCG
TGGCTGATGTGGCGGAGGAGGGGAACTTCCAGTTCCGAGTGTCCGCTCTCAACAGCTTTGGTCAGAGTCCCTACCTCGAGTTCCCGGGGA
CTGTCCACCTGGCCCCCAAGCTGGCCGTGAGGACACCGCTGAAGGCGGTGCAGGCGGTAGAGGGTGGCGAGGTCACTTTCTCCGTGGACC
TCACGGTGGCCTCAGCGGGTGAGTGGTTCCTGGATGGGCAGGCCCTGAAGGCCAGCAGTGTGTATGAGATCCACTGTGATCGCACCCGGC
ACACGCTCACCATCCGGGAGGTGCCCGCCAGCCTGCACGGGGCGCAGCTGAAGTTCGTGGCCAACGGCATTGAGAGCAGCATCCGGATGG
AGGTCCGGGCGGCCCCAGGGCTGACTGCCAACAAGCCGCCAGCCGCAGCTGCCCGGGAGGTGCTGGCTCGGCTGCACGAGGAGGCGCAGC
TGCTGGCTGAGCTGTCAGATCAGGCTGCGGCTGTGACGTGGCTGAAGGATGGTCGCACACTGTCCCCAGGCCCCAAGTATGAGGTGCAGG
CATCGGCCGGGCGGCGGGTGCTCCTTGTGCGAGATGTGGCCCGGGACGATGCAGGCCTCTACGAGTGCGTCAGCCGCGGGGGCCGCATCG
CCTACCAGCTCTCCGTGCAAGGCCTCGCGCGCTTTCTGCACAAGGACATGGCGGGCAGCTGTGTGGATGCCGTGGCTGGGGGCCCGGCGC
AGTTTGAGTGTGAGACCTCCGAAGCCCACGTCCACGTGCACTGGTACAAGGATGGCATGGAGCTGGGCCACTCCGGTGAGCGCTTCTTGC
AGGAGGATGTGGGGACGCGGCACCGGCTGGTGGCAGCCACAGTCACCAGGCAGGATGAAGGCACCTACTCCTGCCGCGTGGGCGAGGACT
CTGTGGACTTCCGGCTCCGCGTCTCTGAGCCCAAGGTGGTGTTTGCTAAGGAGCAGCTGGCACGCAGGAAGCTGCAGGCAGAGGCAGGAG
CCAGTGCCACACTGAGCTGCGAGGTGGCCCAGGCCCAGACGGAGGTGACGTGGTACAAGGATGGGAAGAAGCTGAGCTCCAGCTCGAAAG
TGTGCATGGAGGCCACAGGCTGCACGCGCAGGCTGGTTGTGCAGCAGGCAGGCCAGGCGGATGCCGGGGAGTATAGCTGCGAGGCTGGGG
GCCAGCGGCTCTCCTTCCATCTGGATGTCAAAGCTGAGGGCACCCGGTGCACGGACCCGCCTGCAGGCAAGCCCGCCATGGCGCCCAAAC
GCAAGGGTGGCCTGAAGCTGAACGCCATCTGCGCCAAGCTGAGCCGCCAGGTGGTGGTGGAGAAGCGAGCTGACGCCGGCTCCCACACGG
AGGGCAGCCCATCGCAGCCCCGGGACCAAGAGCGCAGTGGCCCTGAGTCTGGGGCAGCCCGGGCCCCCCGCAGCGAGGAAGACAAGAGAC
GGGCAGTGATCGAGAAGTGGGTGAACGGGGAGTACAGCGAGGAGCCGGCACCCACACCCGTGTTGGGGCGGATTGCCCGCGAGGGCCTGG
AGCTGCCTCCCGAGGGTGTCTACATGGTGCAGCCCCAGGGGTGCAGCGATGAGGAAGACCACGCGGAGGAGCCCTCCAAGGACGGCGGTG
CCCTGGAGGAGAAGGATTCGGACGGGGCAGCCTCCAAGGAGGACAGCGGCCCCAGCACCAGGCAGGCTTCAGGAGAGGCCTCCTCGCTGC
GGGACTACGCGGCCTCCACCATGACCGAGTTCCTCGGCATGTTTGGCTATGATGACCAGAACACGCGGGACGAGCTGGCCAGGAAGATCA
GCTTTGAGAAGCTGCACGCGGGCTCCACCCCGGAGGCAGCCACCTCCTCCATGCTGCCCACCTCCGAGGATACCCTCAGCAAGCGGGCGC
GGTTCTCTAAGTATGAGGAGTACATCCGCAAGCTCAAGGCTGGCGAGCAGCTCTCCTGGCCGGCCCCCAGCACCAAGACCGAGGAGCGGG
TGGGCAAGGAGGTGGTGGGCACCCTGCCCGGCCTGCGGCTGCCCAGCAGCACGGCCCACCTGGAGACCAAGGCCACCATCCTGCCCCTGC
CGTCGCACAGCAGTGTCCAGATGCAGAACCTGGTAGCCCGGGCCTCCAAGTACGACTTCTTCATCCAAAAACTGAAGACCGGCGAGAATC
TGCGGCCCCAGAACGGGAGCACCTACAAGAAGCCATCCAAGTACGACCTGGAGAATGTCAAGTACCTGCACCTCTTCAAACCCGGGGAGG
GCAGCCCCGACATGGGCGGGGCCATCGCCTTCAAGACAGGCAAGGTGGGGCGCCCTTCCAAGTACGACGTCCGGGGCATCCAGAAGCCAG
GCCCCGCCAAGGTTCCGCCCACCCCCAGCCTGGCTCCCGCACCCCTCGCCAGCGTGCCCAGTGCCCCCAGCGCCCCCGGGCCAGGGCCAG
AGCCTCCTGCCTCCCTGTCCTTCAACACTCCCGAGTACCTGAAGTCAACCTTCTCCAAAACAGACTCCATCACCACGGGGACCGTCTCCA
CTGTCAAGAACGGACTGCCCACAGATAAACCAGCCGTCACTGAAGATGTAAACATTTACCAGAAATATATTGCCAGGTTCTCGGGCAGCC
AGCACTGTGGCCACATCCACTGTGCCTACCAGTACCGCGAGCACTACCACTGCCTTGACCCTGAGTGTAACTACCAGAGGTTCACGAGTA
AGCAGGACGTGATCCGCCACTACAACATGCACAAGAAGCGCGACAACTCCCTGCAGCACGGCTTCATGCGTTTCAGCCCGCTGGACGACT
GCAGCGTCTACTACCACGGCTGCCACCTCAATGGGAAGAGCACCCACTATCACTGCATGCAGGTGGGCTGTAACAAGGTGTACACGAGCA
CGTCTGACGTGATGACCCACGAGAACTTCCACAAGAAGAATACCCAGCTCATTAACGACGGCTTCCAGCGCTTCCGAGCCACCGAAGACT
GTGGCACAGCCGACTGCCAGTTCTACGGACAGAAGACCACGCACTTCCACTGCAGGCGCCCCGGCTGCACATTCACTTTCAAGAACAAGT
GTGACATCGAGAAGCACAAGAGCTACCACATCAAGGACGATGCCTACGCCAAGGACGGCTTCAAGAAGTTCTACAAGTACGAGGAGTGCA
AGTACGAGGGCTGCGTGTACAGCAAGGCTACCAACCACTTCCACTGCATCCGCGCCGGCTGCGGCTTCACCTTCACCTCCACCAGCCAGA
TGACCTCTCACAAGCGCAAGCATGAGCGCCGGCACATCCGCTCCTCGGGCGCGCTGGGGCTGCCGCCCTCGCTGCTGGGCGCCAAGGACA
CGGAGCACGAGGAGTCCAGCAACGACGACCTTGTTGACTTCTCCGCCCTGAGCAGCAAGAACTCCAGCCTGAGCGCCTCCCCTACCAGCC
AGCAGTCCTCTGCGTCCCTGGCTGCCGCCACTGCCGCCACCGAGGCTGGGCCCAGTGCCACCAAACCTCCCAACAGCAAGATCTCGGGGC
TGCTGCCCCAGGGCCTGCCTGGCTCAATCCCCCTGGCCCTGGCCCTCTCCAACTCGGGCCTGCCCACCCCCACGCCCTACTTCCCCATAC
TGGCTGGCCGTGGGAGCACCTCCCTGCCTGTGGGCACCCCCAGCCTCCTGGGTGCCGTGTCGTCTGGGTCAGCAGCCTCAGCCACCCCTG
ACACACCCACGCTGGTCGCCTCGGGAGCTGGAGACTCAGCCCCCGTGGCTGCCGCCTCTGTCCCGGCACCACCCGCCTCCATCATGGAGA
GGATCTCTGCAAGCAAGGGCCTCATCTCGCCCATGATGGCCAGGCTGGCTGCAGCTGCCCTCAAGCCCTCTGCCACCTTTGACCCAGGAA
GCGGGCAGCAGGTCACCCCAGCCAGGTTCCCCCCGGCCCAAGTGAAGCCGGAACCCGGTGAGAGCACCGGCGCCCCAGGCCCCCACGAAG
CCTCCCAGGACCGCAGTCTAGACCTGACTGTGAAGGAGCCCAGCAACGAATCAAATGGCCACGCAGTCCCGGCAAATTCATCTCTTTTAT
CCTCGCTTATGAATAAGATGTCTCAGGGCAACCCTGGCCTGGGCAGCCTGCTGAACATCAAGGCGGAAGCGGAGGGGAGCCCCGCTGCGG
AGCCCTCGCCCTTCCTAGGCAAGGCCGTGAAGGCGCTGGTTCAGGAGAAGTTGGCAGAGCCCTGGAAGGTGTACCTGCGCAGGTTTGGTA
CAAAGGACTTCTGTGACGGCCAGTGTGACTTCCTCCACAAGGCCCACTTCCACTGCGTGGTGGAGGAATGCGGCGCGCTCTTCAGCACCT
TGGACGGGGCCATCAAGCACGCAAACTTCCACTTCCGGACAGAGGGAGGAGCAGCAAAAGGAAACACAGAGGCTGCCTTTCCGGCCTCGG
CCGCCGAGACCAAACCTCCCATGGCCCCCTCGTCCCCTCCGGTCCCTCCTGTCACCACGGCCACGGTGTCCTCTCTGGAGGGGCCCGCTC
CCAGCCCGGCCTCCGTGCCCTCCACCCCCACCCTGCTCGCCTGGAAGCAGCTGGCTTCCACCATACCCCAGATGCCTCAGATCCCAGCGT
CAGTGCCTCACCTGCCCGCCTCGCCCTTGGCAACGACTTCTCTAGAGAACGCCAAGCCCCAGGTCAAACCCGGATTCCTCCAGTTCCAGG
AGAACGATCCTTGCCTCGCCACGGACTGCAAGTACGCCAACAAGTTCCACTTCCACTGTCTCTTTGGGAACTGCAAGTACGTCTGCAAAA
CGTCTGGCAAGGCCGAATCCCACTGCCTGGACCACATCAACCCCAACAACAACCTGGTGAACGTGCGAGACCAGTTTGCATACTACTCTC
TGCAGTGTCTCTGTCCCAACCAGCACTGCGAGTTCCGAATGCGTGGGCACTACCACTGCCTCCGCACCGGCTGCTATTTTGTGACCAACA
TCACCACCAAGCTCCCCTGGCACATCAAGAAGCATGAGAAGGCGGAGCGGCGGGCAGCCAATGGCTTCAAATACTTCACCAAGCGCGAGG
AGTGTGGCAGGCTAGGTTGCAAGTACAACCAGGTGAACAGCCACTTCCACTGCATCCGGGAGGGCTGCCAGTTCTCCTTCCTCCTCAAGC
ACCAGATGACCTCCCACGCGCGGAAGCACATGCGGAGGATGCTGGGGAAGAACTTCGACCGCGTGCCCCCCTCCCAGGGCCCCCCAGGCC
TGATGGATGCTGAGACAGATGAGTGCATGGACTACACTGGCTGCAGCCCAGGCGCCATGTCCTCTGAGTCATCCACCATGGACCGGAGCT
GCTCCAGCACCCCCGTGGGTAACGAGAGCACCGCGGCAGGGAACACCATCTCTATGCCGACAGCCTCGGGGGCCAAAAAGCGCTTCTGGA
TCATCGAGGACATGTCGCCCTTCGGCAAGCGGCGGAAGACGGCGTCCTCCCGGAAGATGCTGGACGAGGGCATGATGCTGGAGGGCTTCC
GGCGCTTCGACCTTTACGAGGACTGCAAGGACGCAGCTTGTCAGTTCTCGCTCAAGGTCACCCACTACCACTGCACGCGCGAGAACTGCG
GCTACAAGTTCTGCGGGCGCACGCACATGTACAAGCACGCGCAGCACCACGACCGCGTGGACAACCTGGTGCTGGACGACTTCAAGCGCT
TCAAGGCCTCACTCAGCTGCCACTTCGCCGACTGCCCCTTCTCGGGCACCAGCACGCACTTCCACTGCCTGCGCTGCCGCTTCCGCTGCA
CCGACAGCACCAAGGTCACGGCGCATCGCAAGCACCACGGCAAACAGGACGTGATCAGCGCCGCGGGCTTCTGCCAGTTCAGCTCCAGCG
CCGACTGCGCCGTGCCCGACTGCAAGTACAAGCTCAAGTGCTCGCACTTCCACTGCACCTTCCCGGGCTGCCGCCACACGGTGGTGGGCA
TGTCGCAGATGGACTCGCACAAGCGCAAGCACGAGAAGCAGGAGCGCGGCGAGCCCGCGGCAGAGGGCCCCGCGCCCGGGCCTCCCATCA
GTCTGGACGGCTCCCTGTCGCTGGGCGCCGAGCCGGGCTCGCTGCTCTTCCTGCAGTCGGCGGCCGCCGGCCTGGGCCTGGCGCTGGGCG
ACGCGGGCGACCCCGGCCCGCCCGACGCCGCCGCCCCCGGGCCGCGCGAGGGCGCCGCCGCCGCCGCCGCCGCAGCTGGGGAGTCCTCGC
AGGAGGACGAGGAGGAGGAGCTGGAGCTGCCGGAGGAGGAGGCCGAAGACGACGAGGACGAGGACGACGACGAGGACGACGACGACGAGG
ACGACGACGAGGACGACGACGACGAGGACCTGCGCACCGACTCGGAGGAGTCGCTGCCCGAGGCGGCGGCGGAGGCGGCGGGCGCGGGCG
CGCGGACCCCGGCCTTGGCGGCGCTGGCGGCCCTGGGCGCCCCCGGCCCCGCGCCCACTGCAGCCTCCTCGCCCTAGCGGCGCCCGCGGG
TGGCCCTGGCGGCGGCCTCGGCCTCGGCCTCGGGAGCGGCGCCGCCCCGCGCGAAGCGGCCCCTGGGCAGAGCCCCGCGCCCCGCCGGTG
CTTCCGGACCCCGAGTCCGTCTCAGGACAGAGGCGGGGACCCCTCTGGTGCTCCGCGGCCGAGGACACAGGCGGCGGCGGTGGCCCTGCT
CTAGGGAGGCCGGGTCTCTTCAGGGAAACAGAAGGTGCTCTTGTCCCGGGGTAGGGAACCTAGGAGCAGGGGTCCCGGGCGAATGCGGCG
CAGCTCCCGGCCGCTGCCCCGGCGCCCCTCCCCGCGGCCGATTCGGCCCCGCGACCATTGCTCAGGACTGGGACGGGCGCTGGGGGCCAC
CGGGACCCCCACCGCGCGCCACCAGGGCGGGGTGGCTCCTGGAGCCGCTGGCGGGGCCTCCCTCATGCAGCTAGGATCCTCCCCCCTGCC
CAGGGGGAGACGGGCAGAAGGCAGTCAGCACGGGTGACACTACAGGGACCGTGGAGGAAGCCTCACGGGAGTAGCAGCCGCGGAGCTCCA
GCTCAGCCCCACCCCAGGGCCCGGCTGCTCCCCCAGGCCTGGGTCGGGTCTGTTTGGCGACTCCCTGGCCCCAGCCTCCGCCCCAGGGAA
ACCGAGGCTGCGTCCAAAACCCAGAGTAGCCCGCTGGGGGCCGGGGCGGGGTCTCGGCCACCCTGGTGGTGCAAACAGGAAGGATGCGCC
TGGTTTTGGCTTTAATGTTCAAAATGGAAAAAAATACAAGAAAGTTGTACAGTATTTTTCCTGTAAAGGTTATTATTCTACATAGAACAA
AAAGGAAGAAAGCAGGCGTGGTGAGAGTGCAGACCCGCCTGGGCCCGGCCTGAGGTTGGAGGCTCAGTCCCGTTTATCCTGTGGGATTTG
GTCCAGGGTTTTTGTAGAGGCCTTAACTGTTTGAGGCTGTCTGTCTTCACAATAGCACTGATGGGAGCTGCGTGATTCCAACTCTTAACT
TGAATTTTGTAGAGACAAGAAAAAAGGACTATTACTGTTGATCCAAGTTTGTAGTTAATTTAACATTTGAGTTCTCTCTTGGTGATGCGT
GTGGCTTTATAGGGCTTTTTTTTTTTTCCAGTTTGTTTTATTACTTTGTTTGGGATGCTTCTTCGCTGGTGCAGTCTACCCAGATTGGGT
TCCCTTTGCAAAACATCCCCCTTCCTGGAGATGATGATGCCATCGAAGCCCGGGCCAGGGCCTGACCTGGCAGGCACACACCTGGCCAGT
GGCTCTGAGGTCCCCGGGGACCGAGTCCCCTGCGAGGGCAGGCTGCCCGAGGCCACACCTGCCCACCTTCCCTACTCCAGGCCACCAGCT
GGTGTCAGATTGGGCCACCGGGAGAGAACAGGCCTAGGAGGGAATGGAAGGCTGGCGGGGAGGCTGTCATCCAGAAGCCTCCTCCCCAGA
GGTCTCCAGGAGGAACCTGGCTCAACTGGGGGGCAGTGGTTTACTTTTCCCTTTTTTCTTCCTTTCTTTTGTCCTCTCAGCTGCCCACAG
CCAGAAAGCCAGGACCACCCGAACTGGACAGGGAGCAGGGAGGGAGGAGTGGTCGCACGGAGCGTACCTGATTCAACAGGAAATCAGTTA
TTTTCTAAAACAGCCCCTACCAGAGCCTCCTGAACTCTGTGGGCACCACGTGCTGCTGTGAGCATCTGCCCAGACAGTGACCCGCCACAG
GCCCCGGGCGTCTGTGGAAGGAGTTTTGTAAAGGAAAAAAAAACACACACACACAAACATTTTTTCAATGTAGCAAAATCAAACTTAAAA
AAAAAAAAGAAGAAAAGAAGAAGATGCCGACAGTGCGGAGTCTAGCCTTTTGTAAACTTCATATTGCACACTAGGACTATAAGCCATTGC
TAGCTCATTTTGAATTTTAACGTGTAATTTTTGTTTTATTTTCTTTCTGTGGGGAAACAATGCTTGATCCACCAATGCTCTTTTTAATGT
TTTATAACTATGTATGTGTATATATATAAATATCAAATAATATGTATGCACATATGTGTGTGTATATATCTATATGTATATACATATATA
GATATATAGAGATATATAGAGAGGTTTTGAGACAAAAAAAATACAGAACGTGAAACCCGAGCTGAACAGCGTGTGCTCTGATTACTTGAA
TCTGGTCTCCTCGGCACCTGGTTATTAAGAACTGAATATTTTTCCACTTGAATTTAGTGCTATTAGAAATTTAATATATGTGTTTTATTT

>In-frame_ENST00000284548_ENST00000377022_TCGA-BB-4223-01A_OBSCN_chr1_228412435_+_CASZ1_chr1_10725628_length(amino acids)=2730AA_start in transcript=74_stop in transcript=8266
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGE
AFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG
TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV
WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPS
TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGE
RPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEV
TFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARL
HEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAV
AGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAKEQLARRKL
QAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKAEGTRCTDPPAGKP
AMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLGRI
AREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTRDE
LARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLETKA
TILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVR
GIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIA
RFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCN
KVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFY
KYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSSLS
ASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSGSA
ASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGESTGA
PGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWKVY
LRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATVSS
LEGPAPSPASVPSTPTLLAWKQLASTIPQMPQIPASVPHLPASPLATTSLENAKPQVKPGFLQFQENDPCLATDCKYANKFHFHCLFGNC
KYVCKTSGKAESHCLDHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLPWHIKKHEKAERRAANGFKY
FTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSHARKHMRRMLGKNFDRVPPSQGPPGLMDAETDECMDYTGCSPGAMSSESS
TMDRSCSSTPVGNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRRFDLYEDCKDAACQFSLKVTHYHC
TRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKRFKASLSCHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAGFC
QFSSSADCAVPDCKYKLKCSHFHCTFPGCRHTVVGMSQMDSHKRKHEKQERGEPAAEGPAPGPPISLDGSLSLGAEPGSLLFLQSAAAGL
GLALGDAGDPGPPDAAAPGPREGAAAAAAAAGESSQEDEEEELELPEEEAEDDEDEDDDEDDDDEDDDEDDDDEDLRTDSEESLPEAAAE

--------------------------------------------------------------
>In-frame_ENST00000284548_ENST00000344008_TCGA-BB-4223-01A_OBSCN_chr1_228412435_+_CASZ1_chr1_10725628_length(transcript)=7072nt_BP=3003nt
TGCCTCCCAGCCTGTGCCCCCAGCCTGCGTGCTGCCCAGAGCCCCCATAGAGAGAGGTCCCCGCCGCCACCCTCATGGATCAGCCACAGT
TCAGCGGGGCGCCCCGCTTTCTCACCCGGCCCAAGGCCTTCGTGGTGTCGGTGGGCAAGGACGCCACCCTCAGCTGCCAGATCGTGGGTA
ATCCCACGCCACAGGTGAGCTGGGAGAAGGACCAGCAGCCGGTGGCGGCCGGCGCGCGCTTCCGTCTGGCCCAGGACGGCGACCTCTACC
GCCTCACTATCCTGGACCTGGCGCTGGGCGACAGTGGGCAATACGTGTGCCGCGCGCGCAATGCCATAGGCGAGGCCTTCGCTGCTGTGG
GCCTGCAGGTGGACGCGGAGGCCGCGTGCGCCGAGCAGGCGCCGCACTTCCTGCTGCGGCCCACGTCCATCCGCGTGCGCGAGGGCTCAG
AGGCCACCTTCCGCTGCCGCGTGGGTGGCTCCCCGAGGCCGGCAGTGAGCTGGTCCAAGGACGGGCGGCGCCTGGGTGAGCCCGACGGCC
CCCGCGTGCGCGTGGAGGAGCTCGGCGAGGCAAGTGCGCTGCGCATTCGGGCGGCGCGGCCGCGCGACGGCGGCACTTACGAGGTCCGCG
CCGAGAACCCGCTGGGCGCTGCCAGCGCCGCCGCGGCGCTAGTGGTGGACTCGGACGCCGCGGACACGGCCAGCCGGCCCGGGACCTCCA
CGGCCGCGCTCCTGGCGCACCTGCAGCGGCGGCGCGAGGCTATGCGCGCCGAGGGCGCCCCCGCCTCACCGCCCAGCACCGGCACGCGCA
CCTGCACGGTGACTGAAGGCAAGCACGCGCGCCTCAGCTGCTACGTGACCGGCGAGCCCAAGCCCGAGACGGTGTGGAAGAAGGACGGCC
AGCTGGTGACCGAGGGCCGGCGCCACGTGGTGTACGAGGACGCGCAGGAGAACTTCGTGCTCAAGATCCTCTTCTGCAAGCAGTCGGACC
GCGGCCTCTACACCTGCACGGCGTCCAACCTCGTGGGCCAGACCTACAGCTCTGTGCTGGTCGTAGTGCGCGAGCCCGCGGTTCCCTTCA
AAAAGCGGCTGCAAGATCTGGAGGTGCGGGAGAAGGAGTCGGCCACGTTCCTATGTGAGGTGCCCCAGCCGTCCACTGAGGCCGCGTGGT
TCAAGGAGGAGACGCGGTTGTGGGCGAGCGCCAAGTACGGCATCGAGGAGGAGGGCACCGAGCGCCGCCTGACCGTGCGCAATGTCTCGG
CCGACGACGACGCGGTGTACATCTGCGAGACGCCAGAGGGCAGCCGCACGGTGGCGGAGCTCGCAGTCCAAGGAAACCTCCTCCGAAAGC
TCCCTCGGAAGACGGCGGTGCGCGTGGGCGACACGGCTATGTTTTGCGTGGAGCTGGCGGTCCCGGTGGGCCCCGTCCACTGGCTGCGGA
ACCAGGAGGAAGTGGTGGCGGGGGGCCGCGTGGCCATCTCCGCGGAGGGCACGCGCCACACACTAACCATCTCCCAGTGCTGCCTGGAGG
ATGTGGGCCAGGTGGCCTTTATGGCTGGCGACTGCCAGACGTCCACCCAGTTCTGCGTGTCGGCCCCCAGGAAGCCTCCCCTGCAACCCC
CTGTGGATCCTGTGGTAAAGGCCAGGATGGAGAGTTCCGTGATTCTCAGCTGGTCCCCACCACCCCATGGGGAACGCCCTGTCACTATCG
ACGGCTACCTGGTAGAGAAGAAGAAGCTTGGCACCTACACCTGGATCAGGTGCCACGAGGCTGAATGGGTGGCTACACCTGAGCTGACCG
TGGCTGATGTGGCGGAGGAGGGGAACTTCCAGTTCCGAGTGTCCGCTCTCAACAGCTTTGGTCAGAGTCCCTACCTCGAGTTCCCGGGGA
CTGTCCACCTGGCCCCCAAGCTGGCCGTGAGGACACCGCTGAAGGCGGTGCAGGCGGTAGAGGGTGGCGAGGTCACTTTCTCCGTGGACC
TCACGGTGGCCTCAGCGGGTGAGTGGTTCCTGGATGGGCAGGCCCTGAAGGCCAGCAGTGTGTATGAGATCCACTGTGATCGCACCCGGC
ACACGCTCACCATCCGGGAGGTGCCCGCCAGCCTGCACGGGGCGCAGCTGAAGTTCGTGGCCAACGGCATTGAGAGCAGCATCCGGATGG
AGGTCCGGGCGGCCCCAGGGCTGACTGCCAACAAGCCGCCAGCCGCAGCTGCCCGGGAGGTGCTGGCTCGGCTGCACGAGGAGGCGCAGC
TGCTGGCTGAGCTGTCAGATCAGGCTGCGGCTGTGACGTGGCTGAAGGATGGTCGCACACTGTCCCCAGGCCCCAAGTATGAGGTGCAGG
CATCGGCCGGGCGGCGGGTGCTCCTTGTGCGAGATGTGGCCCGGGACGATGCAGGCCTCTACGAGTGCGTCAGCCGCGGGGGCCGCATCG
CCTACCAGCTCTCCGTGCAAGGCCTCGCGCGCTTTCTGCACAAGGACATGGCGGGCAGCTGTGTGGATGCCGTGGCTGGGGGCCCGGCGC
AGTTTGAGTGTGAGACCTCCGAAGCCCACGTCCACGTGCACTGGTACAAGGATGGCATGGAGCTGGGCCACTCCGGTGAGCGCTTCTTGC
AGGAGGATGTGGGGACGCGGCACCGGCTGGTGGCAGCCACAGTCACCAGGCAGGATGAAGGCACCTACTCCTGCCGCGTGGGCGAGGACT
CTGTGGACTTCCGGCTCCGCGTCTCTGAGCCCAAGGTGGTGTTTGCTAAGGAGCAGCTGGCACGCAGGAAGCTGCAGGCAGAGGCAGGAG
CCAGTGCCACACTGAGCTGCGAGGTGGCCCAGGCCCAGACGGAGGTGACGTGGTACAAGGATGGGAAGAAGCTGAGCTCCAGCTCGAAAG
TGTGCATGGAGGCCACAGGCTGCACGCGCAGGCTGGTTGTGCAGCAGGCAGGCCAGGCGGATGCCGGGGAGTATAGCTGCGAGGCTGGGG
GCCAGCGGCTCTCCTTCCATCTGGATGTCAAAGCTGAGGGCACCCGGTGCACGGACCCGCCTGCAGGCAAGCCCGCCATGGCGCCCAAAC
GCAAGGGTGGCCTGAAGCTGAACGCCATCTGCGCCAAGCTGAGCCGCCAGGTGGTGGTGGAGAAGCGAGCTGACGCCGGCTCCCACACGG
AGGGCAGCCCATCGCAGCCCCGGGACCAAGAGCGCAGTGGCCCTGAGTCTGGGGCAGCCCGGGCCCCCCGCAGCGAGGAAGACAAGAGAC
GGGCAGTGATCGAGAAGTGGGTGAACGGGGAGTACAGCGAGGAGCCGGCACCCACACCCGTGTTGGGGCGGATTGCCCGCGAGGGCCTGG
AGCTGCCTCCCGAGGGTGTCTACATGGTGCAGCCCCAGGGGTGCAGCGATGAGGAAGACCACGCGGAGGAGCCCTCCAAGGACGGCGGTG
CCCTGGAGGAGAAGGATTCGGACGGGGCAGCCTCCAAGGAGGACAGCGGCCCCAGCACCAGGCAGGCTTCAGGAGAGGCCTCCTCGCTGC
GGGACTACGCGGCCTCCACCATGACCGAGTTCCTCGGCATGTTTGGCTATGATGACCAGAACACGCGGGACGAGCTGGCCAGGAAGATCA
GCTTTGAGAAGCTGCACGCGGGCTCCACCCCGGAGGCAGCCACCTCCTCCATGCTGCCCACCTCCGAGGATACCCTCAGCAAGCGGGCGC
GGTTCTCTAAGTATGAGGAGTACATCCGCAAGCTCAAGGCTGGCGAGCAGCTCTCCTGGCCGGCCCCCAGCACCAAGACCGAGGAGCGGG
TGGGCAAGGAGGTGGTGGGCACCCTGCCCGGCCTGCGGCTGCCCAGCAGCACGGCCCACCTGGAGACCAAGGCCACCATCCTGCCCCTGC
CGTCGCACAGCAGTGTCCAGATGCAGAACCTGGTAGCCCGGGCCTCCAAGTACGACTTCTTCATCCAAAAACTGAAGACCGGCGAGAATC
TGCGGCCCCAGAACGGGAGCACCTACAAGAAGCCATCCAAGTACGACCTGGAGAATGTCAAGTACCTGCACCTCTTCAAACCCGGGGAGG
GCAGCCCCGACATGGGCGGGGCCATCGCCTTCAAGACAGGCAAGGTGGGGCGCCCTTCCAAGTACGACGTCCGGGGCATCCAGAAGCCAG
GCCCCGCCAAGGTTCCGCCCACCCCCAGCCTGGCTCCCGCACCCCTCGCCAGCGTGCCCAGTGCCCCCAGCGCCCCCGGGCCAGGGCCAG
AGCCTCCTGCCTCCCTGTCCTTCAACACTCCCGAGTACCTGAAGTCAACCTTCTCCAAAACAGACTCCATCACCACGGGGACCGTCTCCA
CTGTCAAGAACGGACTGCCCACAGATAAACCAGCCGTCACTGAAGATGTAAACATTTACCAGAAATATATTGCCAGGTTCTCGGGCAGCC
AGCACTGTGGCCACATCCACTGTGCCTACCAGTACCGCGAGCACTACCACTGCCTTGACCCTGAGTGTAACTACCAGAGGTTCACGAGTA
AGCAGGACGTGATCCGCCACTACAACATGCACAAGAAGCGCGACAACTCCCTGCAGCACGGCTTCATGCGTTTCAGCCCGCTGGACGACT
GCAGCGTCTACTACCACGGCTGCCACCTCAATGGGAAGAGCACCCACTATCACTGCATGCAGGTGGGCTGTAACAAGGTGTACACGAGCA
CGTCTGACGTGATGACCCACGAGAACTTCCACAAGAAGAATACCCAGCTCATTAACGACGGCTTCCAGCGCTTCCGAGCCACCGAAGACT
GTGGCACAGCCGACTGCCAGTTCTACGGACAGAAGACCACGCACTTCCACTGCAGGCGCCCCGGCTGCACATTCACTTTCAAGAACAAGT
GTGACATCGAGAAGCACAAGAGCTACCACATCAAGGACGATGCCTACGCCAAGGACGGCTTCAAGAAGTTCTACAAGTACGAGGAGTGCA
AGTACGAGGGCTGCGTGTACAGCAAGGCTACCAACCACTTCCACTGCATCCGCGCCGGCTGCGGCTTCACCTTCACCTCCACCAGCCAGA
TGACCTCTCACAAGCGCAAGCATGAGCGCCGGCACATCCGCTCCTCGGGCGCGCTGGGGCTGCCGCCCTCGCTGCTGGGCGCCAAGGACA
CGGAGCACGAGGAGTCCAGCAACGACGACCTTGTTGACTTCTCCGCCCTGAGCAGCAAGAACTCCAGCCTGAGCGCCTCCCCTACCAGCC
AGCAGTCCTCTGCGTCCCTGGCTGCCGCCACTGCCGCCACCGAGGCTGGGCCCAGTGCCACCAAACCTCCCAACAGCAAGATCTCGGGGC
TGCTGCCCCAGGGCCTGCCTGGCTCAATCCCCCTGGCCCTGGCCCTCTCCAACTCGGGCCTGCCCACCCCCACGCCCTACTTCCCCATAC
TGGCTGGCCGTGGGAGCACCTCCCTGCCTGTGGGCACCCCCAGCCTCCTGGGTGCCGTGTCGTCTGGGTCAGCAGCCTCAGCCACCCCTG
ACACACCCACGCTGGTCGCCTCGGGAGCTGGAGACTCAGCCCCCGTGGCTGCCGCCTCTGTCCCGGCACCACCCGCCTCCATCATGGAGA
GGATCTCTGCAAGCAAGGGCCTCATCTCGCCCATGATGGCCAGGCTGGCTGCAGCTGCCCTCAAGCCCTCTGCCACCTTTGACCCAGGAA
GCGGGCAGCAGGTCACCCCAGCCAGGTTCCCCCCGGCCCAAGTGAAGCCGGAACCCGGTGAGAGCACCGGCGCCCCAGGCCCCCACGAAG
CCTCCCAGGACCGCAGTCTAGACCTGACTGTGAAGGAGCCCAGCAACGAATCAAATGGCCACGCAGTCCCGGCAAATTCATCTCTTTTAT
CCTCGCTTATGAATAAGATGTCTCAGGGCAACCCTGGCCTGGGCAGCCTGCTGAACATCAAGGCGGAAGCGGAGGGGAGCCCCGCTGCGG
AGCCCTCGCCCTTCCTAGGCAAGGCCGTGAAGGCGCTGGTTCAGGAGAAGTTGGCAGAGCCCTGGAAGGTGTACCTGCGCAGGTTTGGTA
CAAAGGACTTCTGTGACGGCCAGTGTGACTTCCTCCACAAGGCCCACTTCCACTGCGTGGTGGAGGAATGCGGCGCGCTCTTCAGCACCT
TGGACGGGGCCATCAAGCACGCAAACTTCCACTTCCGGACAGAGGGAGGAGCAGCAAAAGGAAACACAGAGGCTGCCTTTCCGGCCTCGG
CCGCCGAGACCAAACCTCCCATGGCCCCCTCGTCCCCTCCGGTCCCTCCTGTCACCACGGCCACGGTGTCCTCTCTGGAGGGGCCCGCTC
CCAGCCCGGCCTCCGTGCCCTCCACCCCCACCCTGCTCGCCTGGAAGCAGCTGGCTTCCACCATACCCCAGATGCCTCAGATCCCAGCGT
CAGTGCCTCACCTGCCCGCCTCGCCCTTGGCAACGACTTCTCTAGAGAACGCCAAGCCCCAGGTCAAACCCGGATTCCTCCAGTTCCAGG
AGAAGTGAGTCCCTCGATGAGCCGGGAGTCCCGCGTTCCCCTCGCGTCTCGGGAGTAGGTGCTAGCAAGGGCGCTAGGAGGCCCTGTTCC
TCACTGCGGATGGTGCTGCTGTCCCCAGCCTCTCTGGGGCATGGCCATCGGGTGATGTCCTTCTAGCCAAAGATGCTGCTGCTCCTACCT
CACTGCCTGTCCCAGAGCAGGCCAGCCCGCGTGGGCCGATGGTGGCGGCAGTGGCTACTGCTCCTGCAGGGCATGTGGTGATCCTGCCAG
GGCCAGGTGGGGTGGACTGGGCGTGGTGGTCCTCAGAGGACAACTCCCAGCCTGACAAGGAGGGCTGCGTCTCCCTCCGAGCCTCCGTAT
TGGCCTCCTCTGTGGCTCACACCCATGGCTGAATCTCTGCAGGGCACGTGAAGTCACGGGTAGGGGCCAGGCCCCTCCAGGCCGTCACTG
GCCTGCACAGTGGTCTGAGCTCTTGGGTGGAAGGGACCCTCCTCACTGGATGGTGGTGGCTCCTTGCAGGGAGAACGGTGACTTTGTATT

>In-frame_ENST00000284548_ENST00000344008_TCGA-BB-4223-01A_OBSCN_chr1_228412435_+_CASZ1_chr1_10725628_length(amino acids)=2137AA_start in transcript=74_stop in transcript=6487
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGE
AFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG
TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV
WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPS
TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGE
RPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEV
TFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARL
HEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAV
AGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAKEQLARRKL
QAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKAEGTRCTDPPAGKP
AMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLGRI
AREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTRDE
LARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLETKA
TILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVR
GIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIA
RFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCN
KVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFY
KYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSSLS
ASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSGSA
ASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGESTGA
PGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWKVY
LRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATVSS

--------------------------------------------------------------
>In-frame_ENST00000570156_ENST00000377022_TCGA-BB-4223-01A_OBSCN_chr1_228412435_+_CASZ1_chr1_10725628_length(transcript)=10881nt_BP=3279nt
TGCCTCCCAGCCTGTGCCCCCAGCCTGCGTGCTGCCCAGAGCCCCCATAGAGAGAGGTCCCCGCCGCCACCCTCATGGATCAGCCACAGT
TCAGCGGGGCGCCCCGCTTTCTCACCCGGCCCAAGGCCTTCGTGGTGTCGGTGGGCAAGGACGCCACCCTCAGCTGCCAGATCGTGGGTA
ATCCCACGCCACAGGTGAGCTGGGAGAAGGACCAGCAGCCGGTGGCGGCCGGCGCGCGCTTCCGTCTGGCCCAGGACGGCGACCTCTACC
GCCTCACTATCCTGGACCTGGCGCTGGGCGACAGTGGGCAATACGTGTGCCGCGCGCGCAATGCCATAGGCGAGGCCTTCGCTGCTGTGG
GCCTGCAGGTGGACGCGGAGGCCGCGTGCGCCGAGCAGGCGCCGCACTTCCTGCTGCGGCCCACGTCCATCCGCGTGCGCGAGGGCTCAG
AGGCCACCTTCCGCTGCCGCGTGGGTGGCTCCCCGAGGCCGGCAGTGAGCTGGTCCAAGGACGGGCGGCGCCTGGGTGAGCCCGACGGCC
CCCGCGTGCGCGTGGAGGAGCTCGGCGAGGCAAGTGCGCTGCGCATTCGGGCGGCGCGGCCGCGCGACGGCGGCACTTACGAGGTCCGCG
CCGAGAACCCGCTGGGCGCTGCCAGCGCCGCCGCGGCGCTAGTGGTGGACTCGGACGCCGCGGACACGGCCAGCCGGCCCGGGACCTCCA
CGGCCGCGCTCCTGGCGCACCTGCAGCGGCGGCGCGAGGCTATGCGCGCCGAGGGCGCCCCCGCCTCACCGCCCAGCACCGGCACGCGCA
CCTGCACGGTGACTGAAGGCAAGCACGCGCGCCTCAGCTGCTACGTGACCGGCGAGCCCAAGCCCGAGACGGTGTGGAAGAAGGACGGCC
AGCTGGTGACCGAGGGCCGGCGCCACGTGGTGTACGAGGACGCGCAGGAGAACTTCGTGCTCAAGATCCTCTTCTGCAAGCAGTCGGACC
GCGGCCTCTACACCTGCACGGCGTCCAACCTCGTGGGCCAGACCTACAGCTCTGTGCTGGTCGTAGTGCGCGAGCCCGCGGTTCCCTTCA
AAAAGCGGCTGCAAGATCTGGAGGTGCGGGAGAAGGAGTCGGCCACGTTCCTATGTGAGGTGCCCCAGCCGTCCACTGAGGCCGCGTGGT
TCAAGGAGGAGACGCGGTTGTGGGCGAGCGCCAAGTACGGCATCGAGGAGGAGGGCACCGAGCGCCGCCTGACCGTGCGCAATGTCTCGG
CCGACGACGACGCGGTGTACATCTGCGAGACGCCAGAGGGCAGCCGCACGGTGGCGGAGCTCGCAGTCCAAGGAAACCTCCTCCGAAAGC
TCCCTCGGAAGACGGCGGTGCGCGTGGGCGACACGGCTATGTTTTGCGTGGAGCTGGCGGTCCCGGTGGGCCCCGTCCACTGGCTGCGGA
ACCAGGAGGAAGTGGTGGCGGGGGGCCGCGTGGCCATCTCCGCGGAGGGCACGCGCCACACACTAACCATCTCCCAGTGCTGCCTGGAGG
ATGTGGGCCAGGTGGCCTTTATGGCTGGCGACTGCCAGACGTCCACCCAGTTCTGCGTGTCGGCCCCCAGGAAGCCTCCCCTGCAACCCC
CTGTGGATCCTGTGGTAAAGGCCAGGATGGAGAGTTCCGTGATTCTCAGCTGGTCCCCACCACCCCATGGGGAACGCCCTGTCACTATCG
ACGGCTACCTGGTAGAGAAGAAGAAGCTTGGCACCTACACCTGGATCAGGTGCCACGAGGCTGAATGGGTGGCTACACCTGAGCTGACCG
TGGCTGATGTGGCGGAGGAGGGGAACTTCCAGTTCCGAGTGTCCGCTCTCAACAGCTTTGGTCAGAGTCCCTACCTCGAGTTCCCGGGGA
CTGTCCACCTGGCCCCCAAGCTGGCCGTGAGGACACCGCTGAAGGCGGTGCAGGCGGTAGAGGGTGGCGAGGTCACTTTCTCCGTGGACC
TCACGGTGGCCTCAGCGGGTGAGTGGTTCCTGGATGGGCAGGCCCTGAAGGCCAGCAGTGTGTATGAGATCCACTGTGATCGCACCCGGC
ACACGCTCACCATCCGGGAGGTGCCCGCCAGCCTGCACGGGGCGCAGCTGAAGTTCGTGGCCAACGGCATTGAGAGCAGCATCCGGATGG
AGGTCCGGGCGGCCCCAGGGCTGACTGCCAACAAGCCGCCAGCCGCAGCTGCCCGGGAGGTGCTGGCTCGGCTGCACGAGGAGGCGCAGC
TGCTGGCTGAGCTGTCAGATCAGGCTGCGGCTGTGACGTGGCTGAAGGATGGTCGCACACTGTCCCCAGGCCCCAAGTATGAGGTGCAGG
CATCGGCCGGGCGGCGGGTGCTCCTTGTGCGAGATGTGGCCCGGGACGATGCAGGCCTCTACGAGTGCGTCAGCCGCGGGGGCCGCATCG
CCTACCAGCTCTCCGTGCAAGGCCTCGCGCGCTTTCTGCACAAGGACATGGCGGGCAGCTGTGTGGATGCCGTGGCTGGGGGCCCGGCGC
AGTTTGAGTGTGAGACCTCCGAAGCCCACGTCCACGTGCACTGGTACAAGGATGGCATGGAGCTGGGCCACTCCGGTGAGCGCTTCTTGC
AGGAGGATGTGGGGACGCGGCACCGGCTGGTGGCAGCCACAGTCACCAGGCAGGATGAAGGCACCTACTCCTGCCGCGTGGGCGAGGACT
CTGTGGACTTCCGGCTCCGCGTCTCTGAGCCCAAGGCGGTGTTTGCCAAGGAGCAGCCGGCGTGCAGGGAGGTGCAGGCTGAGGTGGGGG
CCAGCGCCACGCTGAGCTGTGAGGTGGCCCAGGACCAGATGGAGGTGACGTGGTACAAGGACGGGAAGAAGTTGAGCTCCAGCTCGAAAG
TGCACGTGGAGGCTGTGGGCTGTATGCGGAGGCTGGTGGTGCAGCAGGTGGGCCAGGCAGACTCCGGAGAGTACAGCTGTGAGGCCAGGG
GACAGAGGGTCTCCTTCCGCCTGGACGTTGCAGAGCCCAAGGTGGTGTTTGCTAAGGAGCAGCTGGCACGCAGGAAGCTGCAGGCAGAGG
CAGGAGCCAGTGCCACACTGAGCTGCGAGGTGGCCCAGGCCCAGACGGAGGTGACGTGGTACAAGGATGGGAAGAAGCTGAGCTCCAGCT
CGAAAGTGTGCATGGAGGCCACAGGCTGCACGCGCAGGCTGGTTGTGCAGCAGGCAGGCCAGGCGGATGCCGGGGAGTATAGCTGCGAGG
CTGGGGGCCAGCGGCTCTCCTTCCATCTGGATGTCAAAGCTGAGGGCACCCGGTGCACGGACCCGCCTGCAGGCAAGCCCGCCATGGCGC
CCAAACGCAAGGGTGGCCTGAAGCTGAACGCCATCTGCGCCAAGCTGAGCCGCCAGGTGGTGGTGGAGAAGCGAGCTGACGCCGGCTCCC
ACACGGAGGGCAGCCCATCGCAGCCCCGGGACCAAGAGCGCAGTGGCCCTGAGTCTGGGGCAGCCCGGGCCCCCCGCAGCGAGGAAGACA
AGAGACGGGCAGTGATCGAGAAGTGGGTGAACGGGGAGTACAGCGAGGAGCCGGCACCCACACCCGTGTTGGGGCGGATTGCCCGCGAGG
GCCTGGAGCTGCCTCCCGAGGGTGTCTACATGGTGCAGCCCCAGGGGTGCAGCGATGAGGAAGACCACGCGGAGGAGCCCTCCAAGGACG
GCGGTGCCCTGGAGGAGAAGGATTCGGACGGGGCAGCCTCCAAGGAGGACAGCGGCCCCAGCACCAGGCAGGCTTCAGGAGAGGCCTCCT
CGCTGCGGGACTACGCGGCCTCCACCATGACCGAGTTCCTCGGCATGTTTGGCTATGATGACCAGAACACGCGGGACGAGCTGGCCAGGA
AGATCAGCTTTGAGAAGCTGCACGCGGGCTCCACCCCGGAGGCAGCCACCTCCTCCATGCTGCCCACCTCCGAGGATACCCTCAGCAAGC
GGGCGCGGTTCTCTAAGTATGAGGAGTACATCCGCAAGCTCAAGGCTGGCGAGCAGCTCTCCTGGCCGGCCCCCAGCACCAAGACCGAGG
AGCGGGTGGGCAAGGAGGTGGTGGGCACCCTGCCCGGCCTGCGGCTGCCCAGCAGCACGGCCCACCTGGAGACCAAGGCCACCATCCTGC
CCCTGCCGTCGCACAGCAGTGTCCAGATGCAGAACCTGGTAGCCCGGGCCTCCAAGTACGACTTCTTCATCCAAAAACTGAAGACCGGCG
AGAATCTGCGGCCCCAGAACGGGAGCACCTACAAGAAGCCATCCAAGTACGACCTGGAGAATGTCAAGTACCTGCACCTCTTCAAACCCG
GGGAGGGCAGCCCCGACATGGGCGGGGCCATCGCCTTCAAGACAGGCAAGGTGGGGCGCCCTTCCAAGTACGACGTCCGGGGCATCCAGA
AGCCAGGCCCCGCCAAGGTTCCGCCCACCCCCAGCCTGGCTCCCGCACCCCTCGCCAGCGTGCCCAGTGCCCCCAGCGCCCCCGGGCCAG
GGCCAGAGCCTCCTGCCTCCCTGTCCTTCAACACTCCCGAGTACCTGAAGTCAACCTTCTCCAAAACAGACTCCATCACCACGGGGACCG
TCTCCACTGTCAAGAACGGACTGCCCACAGATAAACCAGCCGTCACTGAAGATGTAAACATTTACCAGAAATATATTGCCAGGTTCTCGG
GCAGCCAGCACTGTGGCCACATCCACTGTGCCTACCAGTACCGCGAGCACTACCACTGCCTTGACCCTGAGTGTAACTACCAGAGGTTCA
CGAGTAAGCAGGACGTGATCCGCCACTACAACATGCACAAGAAGCGCGACAACTCCCTGCAGCACGGCTTCATGCGTTTCAGCCCGCTGG
ACGACTGCAGCGTCTACTACCACGGCTGCCACCTCAATGGGAAGAGCACCCACTATCACTGCATGCAGGTGGGCTGTAACAAGGTGTACA
CGAGCACGTCTGACGTGATGACCCACGAGAACTTCCACAAGAAGAATACCCAGCTCATTAACGACGGCTTCCAGCGCTTCCGAGCCACCG
AAGACTGTGGCACAGCCGACTGCCAGTTCTACGGACAGAAGACCACGCACTTCCACTGCAGGCGCCCCGGCTGCACATTCACTTTCAAGA
ACAAGTGTGACATCGAGAAGCACAAGAGCTACCACATCAAGGACGATGCCTACGCCAAGGACGGCTTCAAGAAGTTCTACAAGTACGAGG
AGTGCAAGTACGAGGGCTGCGTGTACAGCAAGGCTACCAACCACTTCCACTGCATCCGCGCCGGCTGCGGCTTCACCTTCACCTCCACCA
GCCAGATGACCTCTCACAAGCGCAAGCATGAGCGCCGGCACATCCGCTCCTCGGGCGCGCTGGGGCTGCCGCCCTCGCTGCTGGGCGCCA
AGGACACGGAGCACGAGGAGTCCAGCAACGACGACCTTGTTGACTTCTCCGCCCTGAGCAGCAAGAACTCCAGCCTGAGCGCCTCCCCTA
CCAGCCAGCAGTCCTCTGCGTCCCTGGCTGCCGCCACTGCCGCCACCGAGGCTGGGCCCAGTGCCACCAAACCTCCCAACAGCAAGATCT
CGGGGCTGCTGCCCCAGGGCCTGCCTGGCTCAATCCCCCTGGCCCTGGCCCTCTCCAACTCGGGCCTGCCCACCCCCACGCCCTACTTCC
CCATACTGGCTGGCCGTGGGAGCACCTCCCTGCCTGTGGGCACCCCCAGCCTCCTGGGTGCCGTGTCGTCTGGGTCAGCAGCCTCAGCCA
CCCCTGACACACCCACGCTGGTCGCCTCGGGAGCTGGAGACTCAGCCCCCGTGGCTGCCGCCTCTGTCCCGGCACCACCCGCCTCCATCA
TGGAGAGGATCTCTGCAAGCAAGGGCCTCATCTCGCCCATGATGGCCAGGCTGGCTGCAGCTGCCCTCAAGCCCTCTGCCACCTTTGACC
CAGGAAGCGGGCAGCAGGTCACCCCAGCCAGGTTCCCCCCGGCCCAAGTGAAGCCGGAACCCGGTGAGAGCACCGGCGCCCCAGGCCCCC
ACGAAGCCTCCCAGGACCGCAGTCTAGACCTGACTGTGAAGGAGCCCAGCAACGAATCAAATGGCCACGCAGTCCCGGCAAATTCATCTC
TTTTATCCTCGCTTATGAATAAGATGTCTCAGGGCAACCCTGGCCTGGGCAGCCTGCTGAACATCAAGGCGGAAGCGGAGGGGAGCCCCG
CTGCGGAGCCCTCGCCCTTCCTAGGCAAGGCCGTGAAGGCGCTGGTTCAGGAGAAGTTGGCAGAGCCCTGGAAGGTGTACCTGCGCAGGT
TTGGTACAAAGGACTTCTGTGACGGCCAGTGTGACTTCCTCCACAAGGCCCACTTCCACTGCGTGGTGGAGGAATGCGGCGCGCTCTTCA
GCACCTTGGACGGGGCCATCAAGCACGCAAACTTCCACTTCCGGACAGAGGGAGGAGCAGCAAAAGGAAACACAGAGGCTGCCTTTCCGG
CCTCGGCCGCCGAGACCAAACCTCCCATGGCCCCCTCGTCCCCTCCGGTCCCTCCTGTCACCACGGCCACGGTGTCCTCTCTGGAGGGGC
CCGCTCCCAGCCCGGCCTCCGTGCCCTCCACCCCCACCCTGCTCGCCTGGAAGCAGCTGGCTTCCACCATACCCCAGATGCCTCAGATCC
CAGCGTCAGTGCCTCACCTGCCCGCCTCGCCCTTGGCAACGACTTCTCTAGAGAACGCCAAGCCCCAGGTCAAACCCGGATTCCTCCAGT
TCCAGGAGAACGATCCTTGCCTCGCCACGGACTGCAAGTACGCCAACAAGTTCCACTTCCACTGTCTCTTTGGGAACTGCAAGTACGTCT
GCAAAACGTCTGGCAAGGCCGAATCCCACTGCCTGGACCACATCAACCCCAACAACAACCTGGTGAACGTGCGAGACCAGTTTGCATACT
ACTCTCTGCAGTGTCTCTGTCCCAACCAGCACTGCGAGTTCCGAATGCGTGGGCACTACCACTGCCTCCGCACCGGCTGCTATTTTGTGA
CCAACATCACCACCAAGCTCCCCTGGCACATCAAGAAGCATGAGAAGGCGGAGCGGCGGGCAGCCAATGGCTTCAAATACTTCACCAAGC
GCGAGGAGTGTGGCAGGCTAGGTTGCAAGTACAACCAGGTGAACAGCCACTTCCACTGCATCCGGGAGGGCTGCCAGTTCTCCTTCCTCC
TCAAGCACCAGATGACCTCCCACGCGCGGAAGCACATGCGGAGGATGCTGGGGAAGAACTTCGACCGCGTGCCCCCCTCCCAGGGCCCCC
CAGGCCTGATGGATGCTGAGACAGATGAGTGCATGGACTACACTGGCTGCAGCCCAGGCGCCATGTCCTCTGAGTCATCCACCATGGACC
GGAGCTGCTCCAGCACCCCCGTGGGTAACGAGAGCACCGCGGCAGGGAACACCATCTCTATGCCGACAGCCTCGGGGGCCAAAAAGCGCT
TCTGGATCATCGAGGACATGTCGCCCTTCGGCAAGCGGCGGAAGACGGCGTCCTCCCGGAAGATGCTGGACGAGGGCATGATGCTGGAGG
GCTTCCGGCGCTTCGACCTTTACGAGGACTGCAAGGACGCAGCTTGTCAGTTCTCGCTCAAGGTCACCCACTACCACTGCACGCGCGAGA
ACTGCGGCTACAAGTTCTGCGGGCGCACGCACATGTACAAGCACGCGCAGCACCACGACCGCGTGGACAACCTGGTGCTGGACGACTTCA
AGCGCTTCAAGGCCTCACTCAGCTGCCACTTCGCCGACTGCCCCTTCTCGGGCACCAGCACGCACTTCCACTGCCTGCGCTGCCGCTTCC
GCTGCACCGACAGCACCAAGGTCACGGCGCATCGCAAGCACCACGGCAAACAGGACGTGATCAGCGCCGCGGGCTTCTGCCAGTTCAGCT
CCAGCGCCGACTGCGCCGTGCCCGACTGCAAGTACAAGCTCAAGTGCTCGCACTTCCACTGCACCTTCCCGGGCTGCCGCCACACGGTGG
TGGGCATGTCGCAGATGGACTCGCACAAGCGCAAGCACGAGAAGCAGGAGCGCGGCGAGCCCGCGGCAGAGGGCCCCGCGCCCGGGCCTC
CCATCAGTCTGGACGGCTCCCTGTCGCTGGGCGCCGAGCCGGGCTCGCTGCTCTTCCTGCAGTCGGCGGCCGCCGGCCTGGGCCTGGCGC
TGGGCGACGCGGGCGACCCCGGCCCGCCCGACGCCGCCGCCCCCGGGCCGCGCGAGGGCGCCGCCGCCGCCGCCGCCGCAGCTGGGGAGT
CCTCGCAGGAGGACGAGGAGGAGGAGCTGGAGCTGCCGGAGGAGGAGGCCGAAGACGACGAGGACGAGGACGACGACGAGGACGACGACG
ACGAGGACGACGACGAGGACGACGACGACGAGGACCTGCGCACCGACTCGGAGGAGTCGCTGCCCGAGGCGGCGGCGGAGGCGGCGGGCG
CGGGCGCGCGGACCCCGGCCTTGGCGGCGCTGGCGGCCCTGGGCGCCCCCGGCCCCGCGCCCACTGCAGCCTCCTCGCCCTAGCGGCGCC
CGCGGGTGGCCCTGGCGGCGGCCTCGGCCTCGGCCTCGGGAGCGGCGCCGCCCCGCGCGAAGCGGCCCCTGGGCAGAGCCCCGCGCCCCG
CCGGTGCTTCCGGACCCCGAGTCCGTCTCAGGACAGAGGCGGGGACCCCTCTGGTGCTCCGCGGCCGAGGACACAGGCGGCGGCGGTGGC
CCTGCTCTAGGGAGGCCGGGTCTCTTCAGGGAAACAGAAGGTGCTCTTGTCCCGGGGTAGGGAACCTAGGAGCAGGGGTCCCGGGCGAAT
GCGGCGCAGCTCCCGGCCGCTGCCCCGGCGCCCCTCCCCGCGGCCGATTCGGCCCCGCGACCATTGCTCAGGACTGGGACGGGCGCTGGG
GGCCACCGGGACCCCCACCGCGCGCCACCAGGGCGGGGTGGCTCCTGGAGCCGCTGGCGGGGCCTCCCTCATGCAGCTAGGATCCTCCCC
CCTGCCCAGGGGGAGACGGGCAGAAGGCAGTCAGCACGGGTGACACTACAGGGACCGTGGAGGAAGCCTCACGGGAGTAGCAGCCGCGGA
GCTCCAGCTCAGCCCCACCCCAGGGCCCGGCTGCTCCCCCAGGCCTGGGTCGGGTCTGTTTGGCGACTCCCTGGCCCCAGCCTCCGCCCC
AGGGAAACCGAGGCTGCGTCCAAAACCCAGAGTAGCCCGCTGGGGGCCGGGGCGGGGTCTCGGCCACCCTGGTGGTGCAAACAGGAAGGA
TGCGCCTGGTTTTGGCTTTAATGTTCAAAATGGAAAAAAATACAAGAAAGTTGTACAGTATTTTTCCTGTAAAGGTTATTATTCTACATA
GAACAAAAAGGAAGAAAGCAGGCGTGGTGAGAGTGCAGACCCGCCTGGGCCCGGCCTGAGGTTGGAGGCTCAGTCCCGTTTATCCTGTGG
GATTTGGTCCAGGGTTTTTGTAGAGGCCTTAACTGTTTGAGGCTGTCTGTCTTCACAATAGCACTGATGGGAGCTGCGTGATTCCAACTC
TTAACTTGAATTTTGTAGAGACAAGAAAAAAGGACTATTACTGTTGATCCAAGTTTGTAGTTAATTTAACATTTGAGTTCTCTCTTGGTG
ATGCGTGTGGCTTTATAGGGCTTTTTTTTTTTTCCAGTTTGTTTTATTACTTTGTTTGGGATGCTTCTTCGCTGGTGCAGTCTACCCAGA
TTGGGTTCCCTTTGCAAAACATCCCCCTTCCTGGAGATGATGATGCCATCGAAGCCCGGGCCAGGGCCTGACCTGGCAGGCACACACCTG
GCCAGTGGCTCTGAGGTCCCCGGGGACCGAGTCCCCTGCGAGGGCAGGCTGCCCGAGGCCACACCTGCCCACCTTCCCTACTCCAGGCCA
CCAGCTGGTGTCAGATTGGGCCACCGGGAGAGAACAGGCCTAGGAGGGAATGGAAGGCTGGCGGGGAGGCTGTCATCCAGAAGCCTCCTC
CCCAGAGGTCTCCAGGAGGAACCTGGCTCAACTGGGGGGCAGTGGTTTACTTTTCCCTTTTTTCTTCCTTTCTTTTGTCCTCTCAGCTGC
CCACAGCCAGAAAGCCAGGACCACCCGAACTGGACAGGGAGCAGGGAGGGAGGAGTGGTCGCACGGAGCGTACCTGATTCAACAGGAAAT
CAGTTATTTTCTAAAACAGCCCCTACCAGAGCCTCCTGAACTCTGTGGGCACCACGTGCTGCTGTGAGCATCTGCCCAGACAGTGACCCG
CCACAGGCCCCGGGCGTCTGTGGAAGGAGTTTTGTAAAGGAAAAAAAAACACACACACACAAACATTTTTTCAATGTAGCAAAATCAAAC
TTAAAAAAAAAAAAGAAGAAAAGAAGAAGATGCCGACAGTGCGGAGTCTAGCCTTTTGTAAACTTCATATTGCACACTAGGACTATAAGC
CATTGCTAGCTCATTTTGAATTTTAACGTGTAATTTTTGTTTTATTTTCTTTCTGTGGGGAAACAATGCTTGATCCACCAATGCTCTTTT
TAATGTTTTATAACTATGTATGTGTATATATATAAATATCAAATAATATGTATGCACATATGTGTGTGTATATATCTATATGTATATACA
TATATAGATATATAGAGATATATAGAGAGGTTTTGAGACAAAAAAAATACAGAACGTGAAACCCGAGCTGAACAGCGTGTGCTCTGATTA
CTTGAATCTGGTCTCCTCGGCACCTGGTTATTAAGAACTGAATATTTTTCCACTTGAATTTAGTGCTATTAGAAATTTAATATATGTGTT

>In-frame_ENST00000570156_ENST00000377022_TCGA-BB-4223-01A_OBSCN_chr1_228412435_+_CASZ1_chr1_10725628_length(amino acids)=2822AA_start in transcript=74_stop in transcript=8542
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGE
AFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG
TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV
WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPS
TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGE
RPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEV
TFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARL
HEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAV
AGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKAVFAKEQPACREV
QAEVGASATLSCEVAQDQMEVTWYKDGKKLSSSSKVHVEAVGCMRRLVVQQVGQADSGEYSCEARGQRVSFRLDVAEPKVVFAKEQLARR
KLQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKAEGTRCTDPPAG
KPAMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLG
RIAREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTR
DELARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLET
KATILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYD
VRGIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKY
IARFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVG
CNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKK
FYKYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSS
LSASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSG
SAASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGEST
GAPGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWK
VYLRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATV
SSLEGPAPSPASVPSTPTLLAWKQLASTIPQMPQIPASVPHLPASPLATTSLENAKPQVKPGFLQFQENDPCLATDCKYANKFHFHCLFG
NCKYVCKTSGKAESHCLDHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLPWHIKKHEKAERRAANGF
KYFTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSHARKHMRRMLGKNFDRVPPSQGPPGLMDAETDECMDYTGCSPGAMSSE
SSTMDRSCSSTPVGNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRRFDLYEDCKDAACQFSLKVTHY
HCTRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKRFKASLSCHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAG
FCQFSSSADCAVPDCKYKLKCSHFHCTFPGCRHTVVGMSQMDSHKRKHEKQERGEPAAEGPAPGPPISLDGSLSLGAEPGSLLFLQSAAA
GLGLALGDAGDPGPPDAAAPGPREGAAAAAAAAGESSQEDEEEELELPEEEAEDDEDEDDDEDDDDEDDDEDDDDEDLRTDSEESLPEAA

--------------------------------------------------------------
>In-frame_ENST00000570156_ENST00000344008_TCGA-BB-4223-01A_OBSCN_chr1_228412435_+_CASZ1_chr1_10725628_length(transcript)=7348nt_BP=3279nt
TGCCTCCCAGCCTGTGCCCCCAGCCTGCGTGCTGCCCAGAGCCCCCATAGAGAGAGGTCCCCGCCGCCACCCTCATGGATCAGCCACAGT
TCAGCGGGGCGCCCCGCTTTCTCACCCGGCCCAAGGCCTTCGTGGTGTCGGTGGGCAAGGACGCCACCCTCAGCTGCCAGATCGTGGGTA
ATCCCACGCCACAGGTGAGCTGGGAGAAGGACCAGCAGCCGGTGGCGGCCGGCGCGCGCTTCCGTCTGGCCCAGGACGGCGACCTCTACC
GCCTCACTATCCTGGACCTGGCGCTGGGCGACAGTGGGCAATACGTGTGCCGCGCGCGCAATGCCATAGGCGAGGCCTTCGCTGCTGTGG
GCCTGCAGGTGGACGCGGAGGCCGCGTGCGCCGAGCAGGCGCCGCACTTCCTGCTGCGGCCCACGTCCATCCGCGTGCGCGAGGGCTCAG
AGGCCACCTTCCGCTGCCGCGTGGGTGGCTCCCCGAGGCCGGCAGTGAGCTGGTCCAAGGACGGGCGGCGCCTGGGTGAGCCCGACGGCC
CCCGCGTGCGCGTGGAGGAGCTCGGCGAGGCAAGTGCGCTGCGCATTCGGGCGGCGCGGCCGCGCGACGGCGGCACTTACGAGGTCCGCG
CCGAGAACCCGCTGGGCGCTGCCAGCGCCGCCGCGGCGCTAGTGGTGGACTCGGACGCCGCGGACACGGCCAGCCGGCCCGGGACCTCCA
CGGCCGCGCTCCTGGCGCACCTGCAGCGGCGGCGCGAGGCTATGCGCGCCGAGGGCGCCCCCGCCTCACCGCCCAGCACCGGCACGCGCA
CCTGCACGGTGACTGAAGGCAAGCACGCGCGCCTCAGCTGCTACGTGACCGGCGAGCCCAAGCCCGAGACGGTGTGGAAGAAGGACGGCC
AGCTGGTGACCGAGGGCCGGCGCCACGTGGTGTACGAGGACGCGCAGGAGAACTTCGTGCTCAAGATCCTCTTCTGCAAGCAGTCGGACC
GCGGCCTCTACACCTGCACGGCGTCCAACCTCGTGGGCCAGACCTACAGCTCTGTGCTGGTCGTAGTGCGCGAGCCCGCGGTTCCCTTCA
AAAAGCGGCTGCAAGATCTGGAGGTGCGGGAGAAGGAGTCGGCCACGTTCCTATGTGAGGTGCCCCAGCCGTCCACTGAGGCCGCGTGGT
TCAAGGAGGAGACGCGGTTGTGGGCGAGCGCCAAGTACGGCATCGAGGAGGAGGGCACCGAGCGCCGCCTGACCGTGCGCAATGTCTCGG
CCGACGACGACGCGGTGTACATCTGCGAGACGCCAGAGGGCAGCCGCACGGTGGCGGAGCTCGCAGTCCAAGGAAACCTCCTCCGAAAGC
TCCCTCGGAAGACGGCGGTGCGCGTGGGCGACACGGCTATGTTTTGCGTGGAGCTGGCGGTCCCGGTGGGCCCCGTCCACTGGCTGCGGA
ACCAGGAGGAAGTGGTGGCGGGGGGCCGCGTGGCCATCTCCGCGGAGGGCACGCGCCACACACTAACCATCTCCCAGTGCTGCCTGGAGG
ATGTGGGCCAGGTGGCCTTTATGGCTGGCGACTGCCAGACGTCCACCCAGTTCTGCGTGTCGGCCCCCAGGAAGCCTCCCCTGCAACCCC
CTGTGGATCCTGTGGTAAAGGCCAGGATGGAGAGTTCCGTGATTCTCAGCTGGTCCCCACCACCCCATGGGGAACGCCCTGTCACTATCG
ACGGCTACCTGGTAGAGAAGAAGAAGCTTGGCACCTACACCTGGATCAGGTGCCACGAGGCTGAATGGGTGGCTACACCTGAGCTGACCG
TGGCTGATGTGGCGGAGGAGGGGAACTTCCAGTTCCGAGTGTCCGCTCTCAACAGCTTTGGTCAGAGTCCCTACCTCGAGTTCCCGGGGA
CTGTCCACCTGGCCCCCAAGCTGGCCGTGAGGACACCGCTGAAGGCGGTGCAGGCGGTAGAGGGTGGCGAGGTCACTTTCTCCGTGGACC
TCACGGTGGCCTCAGCGGGTGAGTGGTTCCTGGATGGGCAGGCCCTGAAGGCCAGCAGTGTGTATGAGATCCACTGTGATCGCACCCGGC
ACACGCTCACCATCCGGGAGGTGCCCGCCAGCCTGCACGGGGCGCAGCTGAAGTTCGTGGCCAACGGCATTGAGAGCAGCATCCGGATGG
AGGTCCGGGCGGCCCCAGGGCTGACTGCCAACAAGCCGCCAGCCGCAGCTGCCCGGGAGGTGCTGGCTCGGCTGCACGAGGAGGCGCAGC
TGCTGGCTGAGCTGTCAGATCAGGCTGCGGCTGTGACGTGGCTGAAGGATGGTCGCACACTGTCCCCAGGCCCCAAGTATGAGGTGCAGG
CATCGGCCGGGCGGCGGGTGCTCCTTGTGCGAGATGTGGCCCGGGACGATGCAGGCCTCTACGAGTGCGTCAGCCGCGGGGGCCGCATCG
CCTACCAGCTCTCCGTGCAAGGCCTCGCGCGCTTTCTGCACAAGGACATGGCGGGCAGCTGTGTGGATGCCGTGGCTGGGGGCCCGGCGC
AGTTTGAGTGTGAGACCTCCGAAGCCCACGTCCACGTGCACTGGTACAAGGATGGCATGGAGCTGGGCCACTCCGGTGAGCGCTTCTTGC
AGGAGGATGTGGGGACGCGGCACCGGCTGGTGGCAGCCACAGTCACCAGGCAGGATGAAGGCACCTACTCCTGCCGCGTGGGCGAGGACT
CTGTGGACTTCCGGCTCCGCGTCTCTGAGCCCAAGGCGGTGTTTGCCAAGGAGCAGCCGGCGTGCAGGGAGGTGCAGGCTGAGGTGGGGG
CCAGCGCCACGCTGAGCTGTGAGGTGGCCCAGGACCAGATGGAGGTGACGTGGTACAAGGACGGGAAGAAGTTGAGCTCCAGCTCGAAAG
TGCACGTGGAGGCTGTGGGCTGTATGCGGAGGCTGGTGGTGCAGCAGGTGGGCCAGGCAGACTCCGGAGAGTACAGCTGTGAGGCCAGGG
GACAGAGGGTCTCCTTCCGCCTGGACGTTGCAGAGCCCAAGGTGGTGTTTGCTAAGGAGCAGCTGGCACGCAGGAAGCTGCAGGCAGAGG
CAGGAGCCAGTGCCACACTGAGCTGCGAGGTGGCCCAGGCCCAGACGGAGGTGACGTGGTACAAGGATGGGAAGAAGCTGAGCTCCAGCT
CGAAAGTGTGCATGGAGGCCACAGGCTGCACGCGCAGGCTGGTTGTGCAGCAGGCAGGCCAGGCGGATGCCGGGGAGTATAGCTGCGAGG
CTGGGGGCCAGCGGCTCTCCTTCCATCTGGATGTCAAAGCTGAGGGCACCCGGTGCACGGACCCGCCTGCAGGCAAGCCCGCCATGGCGC
CCAAACGCAAGGGTGGCCTGAAGCTGAACGCCATCTGCGCCAAGCTGAGCCGCCAGGTGGTGGTGGAGAAGCGAGCTGACGCCGGCTCCC
ACACGGAGGGCAGCCCATCGCAGCCCCGGGACCAAGAGCGCAGTGGCCCTGAGTCTGGGGCAGCCCGGGCCCCCCGCAGCGAGGAAGACA
AGAGACGGGCAGTGATCGAGAAGTGGGTGAACGGGGAGTACAGCGAGGAGCCGGCACCCACACCCGTGTTGGGGCGGATTGCCCGCGAGG
GCCTGGAGCTGCCTCCCGAGGGTGTCTACATGGTGCAGCCCCAGGGGTGCAGCGATGAGGAAGACCACGCGGAGGAGCCCTCCAAGGACG
GCGGTGCCCTGGAGGAGAAGGATTCGGACGGGGCAGCCTCCAAGGAGGACAGCGGCCCCAGCACCAGGCAGGCTTCAGGAGAGGCCTCCT
CGCTGCGGGACTACGCGGCCTCCACCATGACCGAGTTCCTCGGCATGTTTGGCTATGATGACCAGAACACGCGGGACGAGCTGGCCAGGA
AGATCAGCTTTGAGAAGCTGCACGCGGGCTCCACCCCGGAGGCAGCCACCTCCTCCATGCTGCCCACCTCCGAGGATACCCTCAGCAAGC
GGGCGCGGTTCTCTAAGTATGAGGAGTACATCCGCAAGCTCAAGGCTGGCGAGCAGCTCTCCTGGCCGGCCCCCAGCACCAAGACCGAGG
AGCGGGTGGGCAAGGAGGTGGTGGGCACCCTGCCCGGCCTGCGGCTGCCCAGCAGCACGGCCCACCTGGAGACCAAGGCCACCATCCTGC
CCCTGCCGTCGCACAGCAGTGTCCAGATGCAGAACCTGGTAGCCCGGGCCTCCAAGTACGACTTCTTCATCCAAAAACTGAAGACCGGCG
AGAATCTGCGGCCCCAGAACGGGAGCACCTACAAGAAGCCATCCAAGTACGACCTGGAGAATGTCAAGTACCTGCACCTCTTCAAACCCG
GGGAGGGCAGCCCCGACATGGGCGGGGCCATCGCCTTCAAGACAGGCAAGGTGGGGCGCCCTTCCAAGTACGACGTCCGGGGCATCCAGA
AGCCAGGCCCCGCCAAGGTTCCGCCCACCCCCAGCCTGGCTCCCGCACCCCTCGCCAGCGTGCCCAGTGCCCCCAGCGCCCCCGGGCCAG
GGCCAGAGCCTCCTGCCTCCCTGTCCTTCAACACTCCCGAGTACCTGAAGTCAACCTTCTCCAAAACAGACTCCATCACCACGGGGACCG
TCTCCACTGTCAAGAACGGACTGCCCACAGATAAACCAGCCGTCACTGAAGATGTAAACATTTACCAGAAATATATTGCCAGGTTCTCGG
GCAGCCAGCACTGTGGCCACATCCACTGTGCCTACCAGTACCGCGAGCACTACCACTGCCTTGACCCTGAGTGTAACTACCAGAGGTTCA
CGAGTAAGCAGGACGTGATCCGCCACTACAACATGCACAAGAAGCGCGACAACTCCCTGCAGCACGGCTTCATGCGTTTCAGCCCGCTGG
ACGACTGCAGCGTCTACTACCACGGCTGCCACCTCAATGGGAAGAGCACCCACTATCACTGCATGCAGGTGGGCTGTAACAAGGTGTACA
CGAGCACGTCTGACGTGATGACCCACGAGAACTTCCACAAGAAGAATACCCAGCTCATTAACGACGGCTTCCAGCGCTTCCGAGCCACCG
AAGACTGTGGCACAGCCGACTGCCAGTTCTACGGACAGAAGACCACGCACTTCCACTGCAGGCGCCCCGGCTGCACATTCACTTTCAAGA
ACAAGTGTGACATCGAGAAGCACAAGAGCTACCACATCAAGGACGATGCCTACGCCAAGGACGGCTTCAAGAAGTTCTACAAGTACGAGG
AGTGCAAGTACGAGGGCTGCGTGTACAGCAAGGCTACCAACCACTTCCACTGCATCCGCGCCGGCTGCGGCTTCACCTTCACCTCCACCA
GCCAGATGACCTCTCACAAGCGCAAGCATGAGCGCCGGCACATCCGCTCCTCGGGCGCGCTGGGGCTGCCGCCCTCGCTGCTGGGCGCCA
AGGACACGGAGCACGAGGAGTCCAGCAACGACGACCTTGTTGACTTCTCCGCCCTGAGCAGCAAGAACTCCAGCCTGAGCGCCTCCCCTA
CCAGCCAGCAGTCCTCTGCGTCCCTGGCTGCCGCCACTGCCGCCACCGAGGCTGGGCCCAGTGCCACCAAACCTCCCAACAGCAAGATCT
CGGGGCTGCTGCCCCAGGGCCTGCCTGGCTCAATCCCCCTGGCCCTGGCCCTCTCCAACTCGGGCCTGCCCACCCCCACGCCCTACTTCC
CCATACTGGCTGGCCGTGGGAGCACCTCCCTGCCTGTGGGCACCCCCAGCCTCCTGGGTGCCGTGTCGTCTGGGTCAGCAGCCTCAGCCA
CCCCTGACACACCCACGCTGGTCGCCTCGGGAGCTGGAGACTCAGCCCCCGTGGCTGCCGCCTCTGTCCCGGCACCACCCGCCTCCATCA
TGGAGAGGATCTCTGCAAGCAAGGGCCTCATCTCGCCCATGATGGCCAGGCTGGCTGCAGCTGCCCTCAAGCCCTCTGCCACCTTTGACC
CAGGAAGCGGGCAGCAGGTCACCCCAGCCAGGTTCCCCCCGGCCCAAGTGAAGCCGGAACCCGGTGAGAGCACCGGCGCCCCAGGCCCCC
ACGAAGCCTCCCAGGACCGCAGTCTAGACCTGACTGTGAAGGAGCCCAGCAACGAATCAAATGGCCACGCAGTCCCGGCAAATTCATCTC
TTTTATCCTCGCTTATGAATAAGATGTCTCAGGGCAACCCTGGCCTGGGCAGCCTGCTGAACATCAAGGCGGAAGCGGAGGGGAGCCCCG
CTGCGGAGCCCTCGCCCTTCCTAGGCAAGGCCGTGAAGGCGCTGGTTCAGGAGAAGTTGGCAGAGCCCTGGAAGGTGTACCTGCGCAGGT
TTGGTACAAAGGACTTCTGTGACGGCCAGTGTGACTTCCTCCACAAGGCCCACTTCCACTGCGTGGTGGAGGAATGCGGCGCGCTCTTCA
GCACCTTGGACGGGGCCATCAAGCACGCAAACTTCCACTTCCGGACAGAGGGAGGAGCAGCAAAAGGAAACACAGAGGCTGCCTTTCCGG
CCTCGGCCGCCGAGACCAAACCTCCCATGGCCCCCTCGTCCCCTCCGGTCCCTCCTGTCACCACGGCCACGGTGTCCTCTCTGGAGGGGC
CCGCTCCCAGCCCGGCCTCCGTGCCCTCCACCCCCACCCTGCTCGCCTGGAAGCAGCTGGCTTCCACCATACCCCAGATGCCTCAGATCC
CAGCGTCAGTGCCTCACCTGCCCGCCTCGCCCTTGGCAACGACTTCTCTAGAGAACGCCAAGCCCCAGGTCAAACCCGGATTCCTCCAGT
TCCAGGAGAAGTGAGTCCCTCGATGAGCCGGGAGTCCCGCGTTCCCCTCGCGTCTCGGGAGTAGGTGCTAGCAAGGGCGCTAGGAGGCCC
TGTTCCTCACTGCGGATGGTGCTGCTGTCCCCAGCCTCTCTGGGGCATGGCCATCGGGTGATGTCCTTCTAGCCAAAGATGCTGCTGCTC
CTACCTCACTGCCTGTCCCAGAGCAGGCCAGCCCGCGTGGGCCGATGGTGGCGGCAGTGGCTACTGCTCCTGCAGGGCATGTGGTGATCC
TGCCAGGGCCAGGTGGGGTGGACTGGGCGTGGTGGTCCTCAGAGGACAACTCCCAGCCTGACAAGGAGGGCTGCGTCTCCCTCCGAGCCT
CCGTATTGGCCTCCTCTGTGGCTCACACCCATGGCTGAATCTCTGCAGGGCACGTGAAGTCACGGGTAGGGGCCAGGCCCCTCCAGGCCG
TCACTGGCCTGCACAGTGGTCTGAGCTCTTGGGTGGAAGGGACCCTCCTCACTGGATGGTGGTGGCTCCTTGCAGGGAGAACGGTGACTT

>In-frame_ENST00000570156_ENST00000344008_TCGA-BB-4223-01A_OBSCN_chr1_228412435_+_CASZ1_chr1_10725628_length(amino acids)=2229AA_start in transcript=74_stop in transcript=6763
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGE
AFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG
TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV
WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPS
TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGE
RPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEV
TFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARL
HEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAV
AGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKAVFAKEQPACREV
QAEVGASATLSCEVAQDQMEVTWYKDGKKLSSSSKVHVEAVGCMRRLVVQQVGQADSGEYSCEARGQRVSFRLDVAEPKVVFAKEQLARR
KLQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKAEGTRCTDPPAG
KPAMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLG
RIAREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTR
DELARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLET
KATILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYD
VRGIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKY
IARFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVG
CNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKK
FYKYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSS
LSASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSG
SAASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGEST
GAPGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWK
VYLRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATV

--------------------------------------------------------------
>In-frame_ENST00000422127_ENST00000377022_TCGA-BB-4223-01A_OBSCN_chr1_228412435_+_CASZ1_chr1_10725628_length(transcript)=10575nt_BP=2973nt
GCTGCCCAGAGCCCCCATAGAGAGAGGTCCCCGCCGCCACCCTCATGGATCAGCCACAGTTCAGCGGGGCGCCCCGCTTTCTCACCCGGC
CCAAGGCCTTCGTGGTGTCGGTGGGCAAGGACGCCACCCTCAGCTGCCAGATCGTGGGTAATCCCACGCCACAGGTGAGCTGGGAGAAGG
ACCAGCAGCCGGTGGCGGCCGGCGCGCGCTTCCGTCTGGCCCAGGACGGCGACCTCTACCGCCTCACTATCCTGGACCTGGCGCTGGGCG
ACAGTGGGCAATACGTGTGCCGCGCGCGCAATGCCATAGGCGAGGCCTTCGCTGCTGTGGGCCTGCAGGTGGACGCGGAGGCCGCGTGCG
CCGAGCAGGCGCCGCACTTCCTGCTGCGGCCCACGTCCATCCGCGTGCGCGAGGGCTCAGAGGCCACCTTCCGCTGCCGCGTGGGTGGCT
CCCCGAGGCCGGCAGTGAGCTGGTCCAAGGACGGGCGGCGCCTGGGTGAGCCCGACGGCCCCCGCGTGCGCGTGGAGGAGCTCGGCGAGG
CAAGTGCGCTGCGCATTCGGGCGGCGCGGCCGCGCGACGGCGGCACTTACGAGGTCCGCGCCGAGAACCCGCTGGGCGCTGCCAGCGCCG
CCGCGGCGCTAGTGGTGGACTCGGACGCCGCGGACACGGCCAGCCGGCCCGGGACCTCCACGGCCGCGCTCCTGGCGCACCTGCAGCGGC
GGCGCGAGGCTATGCGCGCCGAGGGCGCCCCCGCCTCACCGCCCAGCACCGGCACGCGCACCTGCACGGTGACTGAAGGCAAGCACGCGC
GCCTCAGCTGCTACGTGACCGGCGAGCCCAAGCCCGAGACGGTGTGGAAGAAGGACGGCCAGCTGGTGACCGAGGGCCGGCGCCACGTGG
TGTACGAGGACGCGCAGGAGAACTTCGTGCTCAAGATCCTCTTCTGCAAGCAGTCGGACCGCGGCCTCTACACCTGCACGGCGTCCAACC
TCGTGGGCCAGACCTACAGCTCTGTGCTGGTCGTAGTGCGCGAGCCCGCGGTTCCCTTCAAAAAGCGGCTGCAAGATCTGGAGGTGCGGG
AGAAGGAGTCGGCCACGTTCCTATGTGAGGTGCCCCAGCCGTCCACTGAGGCCGCGTGGTTCAAGGAGGAGACGCGGTTGTGGGCGAGCG
CCAAGTACGGCATCGAGGAGGAGGGCACCGAGCGCCGCCTGACCGTGCGCAATGTCTCGGCCGACGACGACGCGGTGTACATCTGCGAGA
CGCCAGAGGGCAGCCGCACGGTGGCGGAGCTCGCAGTCCAAGGAAACCTCCTCCGAAAGCTCCCTCGGAAGACGGCGGTGCGCGTGGGCG
ACACGGCTATGTTTTGCGTGGAGCTGGCGGTCCCGGTGGGCCCCGTCCACTGGCTGCGGAACCAGGAGGAAGTGGTGGCGGGGGGCCGCG
TGGCCATCTCCGCGGAGGGCACGCGCCACACACTAACCATCTCCCAGTGCTGCCTGGAGGATGTGGGCCAGGTGGCCTTTATGGCTGGCG
ACTGCCAGACGTCCACCCAGTTCTGCGTGTCGGCCCCCAGGAAGCCTCCCCTGCAACCCCCTGTGGATCCTGTGGTAAAGGCCAGGATGG
AGAGTTCCGTGATTCTCAGCTGGTCCCCACCACCCCATGGGGAACGCCCTGTCACTATCGACGGCTACCTGGTAGAGAAGAAGAAGCTTG
GCACCTACACCTGGATCAGGTGCCACGAGGCTGAATGGGTGGCTACACCTGAGCTGACCGTGGCTGATGTGGCGGAGGAGGGGAACTTCC
AGTTCCGAGTGTCCGCTCTCAACAGCTTTGGTCAGAGTCCCTACCTCGAGTTCCCGGGGACTGTCCACCTGGCCCCCAAGCTGGCCGTGA
GGACACCGCTGAAGGCGGTGCAGGCGGTAGAGGGTGGCGAGGTCACTTTCTCCGTGGACCTCACGGTGGCCTCAGCGGGTGAGTGGTTCC
TGGATGGGCAGGCCCTGAAGGCCAGCAGTGTGTATGAGATCCACTGTGATCGCACCCGGCACACGCTCACCATCCGGGAGGTGCCCGCCA
GCCTGCACGGGGCGCAGCTGAAGTTCGTGGCCAACGGCATTGAGAGCAGCATCCGGATGGAGGTCCGGGCGGCCCCAGGGCTGACTGCCA
ACAAGCCGCCAGCCGCAGCTGCCCGGGAGGTGCTGGCTCGGCTGCACGAGGAGGCGCAGCTGCTGGCTGAGCTGTCAGATCAGGCTGCGG
CTGTGACGTGGCTGAAGGATGGTCGCACACTGTCCCCAGGCCCCAAGTATGAGGTGCAGGCATCGGCCGGGCGGCGGGTGCTCCTTGTGC
GAGATGTGGCCCGGGACGATGCAGGCCTCTACGAGTGCGTCAGCCGCGGGGGCCGCATCGCCTACCAGCTCTCCGTGCAAGGCCTCGCGC
GCTTTCTGCACAAGGACATGGCGGGCAGCTGTGTGGATGCCGTGGCTGGGGGCCCGGCGCAGTTTGAGTGTGAGACCTCCGAAGCCCACG
TCCACGTGCACTGGTACAAGGATGGCATGGAGCTGGGCCACTCCGGTGAGCGCTTCTTGCAGGAGGATGTGGGGACGCGGCACCGGCTGG
TGGCAGCCACAGTCACCAGGCAGGATGAAGGCACCTACTCCTGCCGCGTGGGCGAGGACTCTGTGGACTTCCGGCTCCGCGTCTCTGAGC
CCAAGGTGGTGTTTGCTAAGGAGCAGCTGGCACGCAGGAAGCTGCAGGCAGAGGCAGGAGCCAGTGCCACACTGAGCTGCGAGGTGGCCC
AGGCCCAGACGGAGGTGACGTGGTACAAGGATGGGAAGAAGCTGAGCTCCAGCTCGAAAGTGTGCATGGAGGCCACAGGCTGCACGCGCA
GGCTGGTTGTGCAGCAGGCAGGCCAGGCGGATGCCGGGGAGTATAGCTGCGAGGCTGGGGGCCAGCGGCTCTCCTTCCATCTGGATGTCA
AAGCTGAGGGCACCCGGTGCACGGACCCGCCTGCAGGCAAGCCCGCCATGGCGCCCAAACGCAAGGGTGGCCTGAAGCTGAACGCCATCT
GCGCCAAGCTGAGCCGCCAGGTGGTGGTGGAGAAGCGAGCTGACGCCGGCTCCCACACGGAGGGCAGCCCATCGCAGCCCCGGGACCAAG
AGCGCAGTGGCCCTGAGTCTGGGGCAGCCCGGGCCCCCCGCAGCGAGGAAGACAAGAGACGGGCAGTGATCGAGAAGTGGGTGAACGGGG
AGTACAGCGAGGAGCCGGCACCCACACCCGTGTTGGGGCGGATTGCCCGCGAGGGCCTGGAGCTGCCTCCCGAGGGTGTCTACATGGTGC
AGCCCCAGGGGTGCAGCGATGAGGAAGACCACGCGGAGGAGCCCTCCAAGGACGGCGGTGCCCTGGAGGAGAAGGATTCGGACGGGGCAG
CCTCCAAGGAGGACAGCGGCCCCAGCACCAGGCAGGCTTCAGGAGAGGCCTCCTCGCTGCGGGACTACGCGGCCTCCACCATGACCGAGT
TCCTCGGCATGTTTGGCTATGATGACCAGAACACGCGGGACGAGCTGGCCAGGAAGATCAGCTTTGAGAAGCTGCACGCGGGCTCCACCC
CGGAGGCAGCCACCTCCTCCATGCTGCCCACCTCCGAGGATACCCTCAGCAAGCGGGCGCGGTTCTCTAAGTATGAGGAGTACATCCGCA
AGCTCAAGGCTGGCGAGCAGCTCTCCTGGCCGGCCCCCAGCACCAAGACCGAGGAGCGGGTGGGCAAGGAGGTGGTGGGCACCCTGCCCG
GCCTGCGGCTGCCCAGCAGCACGGCCCACCTGGAGACCAAGGCCACCATCCTGCCCCTGCCGTCGCACAGCAGTGTCCAGATGCAGAACC
TGGTAGCCCGGGCCTCCAAGTACGACTTCTTCATCCAAAAACTGAAGACCGGCGAGAATCTGCGGCCCCAGAACGGGAGCACCTACAAGA
AGCCATCCAAGTACGACCTGGAGAATGTCAAGTACCTGCACCTCTTCAAACCCGGGGAGGGCAGCCCCGACATGGGCGGGGCCATCGCCT
TCAAGACAGGCAAGGTGGGGCGCCCTTCCAAGTACGACGTCCGGGGCATCCAGAAGCCAGGCCCCGCCAAGGTTCCGCCCACCCCCAGCC
TGGCTCCCGCACCCCTCGCCAGCGTGCCCAGTGCCCCCAGCGCCCCCGGGCCAGGGCCAGAGCCTCCTGCCTCCCTGTCCTTCAACACTC
CCGAGTACCTGAAGTCAACCTTCTCCAAAACAGACTCCATCACCACGGGGACCGTCTCCACTGTCAAGAACGGACTGCCCACAGATAAAC
CAGCCGTCACTGAAGATGTAAACATTTACCAGAAATATATTGCCAGGTTCTCGGGCAGCCAGCACTGTGGCCACATCCACTGTGCCTACC
AGTACCGCGAGCACTACCACTGCCTTGACCCTGAGTGTAACTACCAGAGGTTCACGAGTAAGCAGGACGTGATCCGCCACTACAACATGC
ACAAGAAGCGCGACAACTCCCTGCAGCACGGCTTCATGCGTTTCAGCCCGCTGGACGACTGCAGCGTCTACTACCACGGCTGCCACCTCA
ATGGGAAGAGCACCCACTATCACTGCATGCAGGTGGGCTGTAACAAGGTGTACACGAGCACGTCTGACGTGATGACCCACGAGAACTTCC
ACAAGAAGAATACCCAGCTCATTAACGACGGCTTCCAGCGCTTCCGAGCCACCGAAGACTGTGGCACAGCCGACTGCCAGTTCTACGGAC
AGAAGACCACGCACTTCCACTGCAGGCGCCCCGGCTGCACATTCACTTTCAAGAACAAGTGTGACATCGAGAAGCACAAGAGCTACCACA
TCAAGGACGATGCCTACGCCAAGGACGGCTTCAAGAAGTTCTACAAGTACGAGGAGTGCAAGTACGAGGGCTGCGTGTACAGCAAGGCTA
CCAACCACTTCCACTGCATCCGCGCCGGCTGCGGCTTCACCTTCACCTCCACCAGCCAGATGACCTCTCACAAGCGCAAGCATGAGCGCC
GGCACATCCGCTCCTCGGGCGCGCTGGGGCTGCCGCCCTCGCTGCTGGGCGCCAAGGACACGGAGCACGAGGAGTCCAGCAACGACGACC
TTGTTGACTTCTCCGCCCTGAGCAGCAAGAACTCCAGCCTGAGCGCCTCCCCTACCAGCCAGCAGTCCTCTGCGTCCCTGGCTGCCGCCA
CTGCCGCCACCGAGGCTGGGCCCAGTGCCACCAAACCTCCCAACAGCAAGATCTCGGGGCTGCTGCCCCAGGGCCTGCCTGGCTCAATCC
CCCTGGCCCTGGCCCTCTCCAACTCGGGCCTGCCCACCCCCACGCCCTACTTCCCCATACTGGCTGGCCGTGGGAGCACCTCCCTGCCTG
TGGGCACCCCCAGCCTCCTGGGTGCCGTGTCGTCTGGGTCAGCAGCCTCAGCCACCCCTGACACACCCACGCTGGTCGCCTCGGGAGCTG
GAGACTCAGCCCCCGTGGCTGCCGCCTCTGTCCCGGCACCACCCGCCTCCATCATGGAGAGGATCTCTGCAAGCAAGGGCCTCATCTCGC
CCATGATGGCCAGGCTGGCTGCAGCTGCCCTCAAGCCCTCTGCCACCTTTGACCCAGGAAGCGGGCAGCAGGTCACCCCAGCCAGGTTCC
CCCCGGCCCAAGTGAAGCCGGAACCCGGTGAGAGCACCGGCGCCCCAGGCCCCCACGAAGCCTCCCAGGACCGCAGTCTAGACCTGACTG
TGAAGGAGCCCAGCAACGAATCAAATGGCCACGCAGTCCCGGCAAATTCATCTCTTTTATCCTCGCTTATGAATAAGATGTCTCAGGGCA
ACCCTGGCCTGGGCAGCCTGCTGAACATCAAGGCGGAAGCGGAGGGGAGCCCCGCTGCGGAGCCCTCGCCCTTCCTAGGCAAGGCCGTGA
AGGCGCTGGTTCAGGAGAAGTTGGCAGAGCCCTGGAAGGTGTACCTGCGCAGGTTTGGTACAAAGGACTTCTGTGACGGCCAGTGTGACT
TCCTCCACAAGGCCCACTTCCACTGCGTGGTGGAGGAATGCGGCGCGCTCTTCAGCACCTTGGACGGGGCCATCAAGCACGCAAACTTCC
ACTTCCGGACAGAGGGAGGAGCAGCAAAAGGAAACACAGAGGCTGCCTTTCCGGCCTCGGCCGCCGAGACCAAACCTCCCATGGCCCCCT
CGTCCCCTCCGGTCCCTCCTGTCACCACGGCCACGGTGTCCTCTCTGGAGGGGCCCGCTCCCAGCCCGGCCTCCGTGCCCTCCACCCCCA
CCCTGCTCGCCTGGAAGCAGCTGGCTTCCACCATACCCCAGATGCCTCAGATCCCAGCGTCAGTGCCTCACCTGCCCGCCTCGCCCTTGG
CAACGACTTCTCTAGAGAACGCCAAGCCCCAGGTCAAACCCGGATTCCTCCAGTTCCAGGAGAACGATCCTTGCCTCGCCACGGACTGCA
AGTACGCCAACAAGTTCCACTTCCACTGTCTCTTTGGGAACTGCAAGTACGTCTGCAAAACGTCTGGCAAGGCCGAATCCCACTGCCTGG
ACCACATCAACCCCAACAACAACCTGGTGAACGTGCGAGACCAGTTTGCATACTACTCTCTGCAGTGTCTCTGTCCCAACCAGCACTGCG
AGTTCCGAATGCGTGGGCACTACCACTGCCTCCGCACCGGCTGCTATTTTGTGACCAACATCACCACCAAGCTCCCCTGGCACATCAAGA
AGCATGAGAAGGCGGAGCGGCGGGCAGCCAATGGCTTCAAATACTTCACCAAGCGCGAGGAGTGTGGCAGGCTAGGTTGCAAGTACAACC
AGGTGAACAGCCACTTCCACTGCATCCGGGAGGGCTGCCAGTTCTCCTTCCTCCTCAAGCACCAGATGACCTCCCACGCGCGGAAGCACA
TGCGGAGGATGCTGGGGAAGAACTTCGACCGCGTGCCCCCCTCCCAGGGCCCCCCAGGCCTGATGGATGCTGAGACAGATGAGTGCATGG
ACTACACTGGCTGCAGCCCAGGCGCCATGTCCTCTGAGTCATCCACCATGGACCGGAGCTGCTCCAGCACCCCCGTGGGTAACGAGAGCA
CCGCGGCAGGGAACACCATCTCTATGCCGACAGCCTCGGGGGCCAAAAAGCGCTTCTGGATCATCGAGGACATGTCGCCCTTCGGCAAGC
GGCGGAAGACGGCGTCCTCCCGGAAGATGCTGGACGAGGGCATGATGCTGGAGGGCTTCCGGCGCTTCGACCTTTACGAGGACTGCAAGG
ACGCAGCTTGTCAGTTCTCGCTCAAGGTCACCCACTACCACTGCACGCGCGAGAACTGCGGCTACAAGTTCTGCGGGCGCACGCACATGT
ACAAGCACGCGCAGCACCACGACCGCGTGGACAACCTGGTGCTGGACGACTTCAAGCGCTTCAAGGCCTCACTCAGCTGCCACTTCGCCG
ACTGCCCCTTCTCGGGCACCAGCACGCACTTCCACTGCCTGCGCTGCCGCTTCCGCTGCACCGACAGCACCAAGGTCACGGCGCATCGCA
AGCACCACGGCAAACAGGACGTGATCAGCGCCGCGGGCTTCTGCCAGTTCAGCTCCAGCGCCGACTGCGCCGTGCCCGACTGCAAGTACA
AGCTCAAGTGCTCGCACTTCCACTGCACCTTCCCGGGCTGCCGCCACACGGTGGTGGGCATGTCGCAGATGGACTCGCACAAGCGCAAGC
ACGAGAAGCAGGAGCGCGGCGAGCCCGCGGCAGAGGGCCCCGCGCCCGGGCCTCCCATCAGTCTGGACGGCTCCCTGTCGCTGGGCGCCG
AGCCGGGCTCGCTGCTCTTCCTGCAGTCGGCGGCCGCCGGCCTGGGCCTGGCGCTGGGCGACGCGGGCGACCCCGGCCCGCCCGACGCCG
CCGCCCCCGGGCCGCGCGAGGGCGCCGCCGCCGCCGCCGCCGCAGCTGGGGAGTCCTCGCAGGAGGACGAGGAGGAGGAGCTGGAGCTGC
CGGAGGAGGAGGCCGAAGACGACGAGGACGAGGACGACGACGAGGACGACGACGACGAGGACGACGACGAGGACGACGACGACGAGGACC
TGCGCACCGACTCGGAGGAGTCGCTGCCCGAGGCGGCGGCGGAGGCGGCGGGCGCGGGCGCGCGGACCCCGGCCTTGGCGGCGCTGGCGG
CCCTGGGCGCCCCCGGCCCCGCGCCCACTGCAGCCTCCTCGCCCTAGCGGCGCCCGCGGGTGGCCCTGGCGGCGGCCTCGGCCTCGGCCT
CGGGAGCGGCGCCGCCCCGCGCGAAGCGGCCCCTGGGCAGAGCCCCGCGCCCCGCCGGTGCTTCCGGACCCCGAGTCCGTCTCAGGACAG
AGGCGGGGACCCCTCTGGTGCTCCGCGGCCGAGGACACAGGCGGCGGCGGTGGCCCTGCTCTAGGGAGGCCGGGTCTCTTCAGGGAAACA
GAAGGTGCTCTTGTCCCGGGGTAGGGAACCTAGGAGCAGGGGTCCCGGGCGAATGCGGCGCAGCTCCCGGCCGCTGCCCCGGCGCCCCTC
CCCGCGGCCGATTCGGCCCCGCGACCATTGCTCAGGACTGGGACGGGCGCTGGGGGCCACCGGGACCCCCACCGCGCGCCACCAGGGCGG
GGTGGCTCCTGGAGCCGCTGGCGGGGCCTCCCTCATGCAGCTAGGATCCTCCCCCCTGCCCAGGGGGAGACGGGCAGAAGGCAGTCAGCA
CGGGTGACACTACAGGGACCGTGGAGGAAGCCTCACGGGAGTAGCAGCCGCGGAGCTCCAGCTCAGCCCCACCCCAGGGCCCGGCTGCTC
CCCCAGGCCTGGGTCGGGTCTGTTTGGCGACTCCCTGGCCCCAGCCTCCGCCCCAGGGAAACCGAGGCTGCGTCCAAAACCCAGAGTAGC
CCGCTGGGGGCCGGGGCGGGGTCTCGGCCACCCTGGTGGTGCAAACAGGAAGGATGCGCCTGGTTTTGGCTTTAATGTTCAAAATGGAAA
AAAATACAAGAAAGTTGTACAGTATTTTTCCTGTAAAGGTTATTATTCTACATAGAACAAAAAGGAAGAAAGCAGGCGTGGTGAGAGTGC
AGACCCGCCTGGGCCCGGCCTGAGGTTGGAGGCTCAGTCCCGTTTATCCTGTGGGATTTGGTCCAGGGTTTTTGTAGAGGCCTTAACTGT
TTGAGGCTGTCTGTCTTCACAATAGCACTGATGGGAGCTGCGTGATTCCAACTCTTAACTTGAATTTTGTAGAGACAAGAAAAAAGGACT
ATTACTGTTGATCCAAGTTTGTAGTTAATTTAACATTTGAGTTCTCTCTTGGTGATGCGTGTGGCTTTATAGGGCTTTTTTTTTTTTCCA
GTTTGTTTTATTACTTTGTTTGGGATGCTTCTTCGCTGGTGCAGTCTACCCAGATTGGGTTCCCTTTGCAAAACATCCCCCTTCCTGGAG
ATGATGATGCCATCGAAGCCCGGGCCAGGGCCTGACCTGGCAGGCACACACCTGGCCAGTGGCTCTGAGGTCCCCGGGGACCGAGTCCCC
TGCGAGGGCAGGCTGCCCGAGGCCACACCTGCCCACCTTCCCTACTCCAGGCCACCAGCTGGTGTCAGATTGGGCCACCGGGAGAGAACA
GGCCTAGGAGGGAATGGAAGGCTGGCGGGGAGGCTGTCATCCAGAAGCCTCCTCCCCAGAGGTCTCCAGGAGGAACCTGGCTCAACTGGG
GGGCAGTGGTTTACTTTTCCCTTTTTTCTTCCTTTCTTTTGTCCTCTCAGCTGCCCACAGCCAGAAAGCCAGGACCACCCGAACTGGACA
GGGAGCAGGGAGGGAGGAGTGGTCGCACGGAGCGTACCTGATTCAACAGGAAATCAGTTATTTTCTAAAACAGCCCCTACCAGAGCCTCC
TGAACTCTGTGGGCACCACGTGCTGCTGTGAGCATCTGCCCAGACAGTGACCCGCCACAGGCCCCGGGCGTCTGTGGAAGGAGTTTTGTA
AAGGAAAAAAAAACACACACACACAAACATTTTTTCAATGTAGCAAAATCAAACTTAAAAAAAAAAAAGAAGAAAAGAAGAAGATGCCGA
CAGTGCGGAGTCTAGCCTTTTGTAAACTTCATATTGCACACTAGGACTATAAGCCATTGCTAGCTCATTTTGAATTTTAACGTGTAATTT
TTGTTTTATTTTCTTTCTGTGGGGAAACAATGCTTGATCCACCAATGCTCTTTTTAATGTTTTATAACTATGTATGTGTATATATATAAA
TATCAAATAATATGTATGCACATATGTGTGTGTATATATCTATATGTATATACATATATAGATATATAGAGATATATAGAGAGGTTTTGA
GACAAAAAAAATACAGAACGTGAAACCCGAGCTGAACAGCGTGTGCTCTGATTACTTGAATCTGGTCTCCTCGGCACCTGGTTATTAAGA
ACTGAATATTTTTCCACTTGAATTTAGTGCTATTAGAAATTTAATATATGTGTTTTATTTATTTGATTTTTTTTTTTTTTTTTGCATGAC

>In-frame_ENST00000422127_ENST00000377022_TCGA-BB-4223-01A_OBSCN_chr1_228412435_+_CASZ1_chr1_10725628_length(amino acids)=2730AA_start in transcript=44_stop in transcript=8236
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGE
AFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG
TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV
WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPS
TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGE
RPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEV
TFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARL
HEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAV
AGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAKEQLARRKL
QAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKAEGTRCTDPPAGKP
AMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLGRI
AREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTRDE
LARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLETKA
TILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVR
GIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIA
RFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCN
KVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFY
KYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSSLS
ASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSGSA
ASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGESTGA
PGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWKVY
LRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATVSS
LEGPAPSPASVPSTPTLLAWKQLASTIPQMPQIPASVPHLPASPLATTSLENAKPQVKPGFLQFQENDPCLATDCKYANKFHFHCLFGNC
KYVCKTSGKAESHCLDHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLPWHIKKHEKAERRAANGFKY
FTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSHARKHMRRMLGKNFDRVPPSQGPPGLMDAETDECMDYTGCSPGAMSSESS
TMDRSCSSTPVGNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRRFDLYEDCKDAACQFSLKVTHYHC
TRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKRFKASLSCHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAGFC
QFSSSADCAVPDCKYKLKCSHFHCTFPGCRHTVVGMSQMDSHKRKHEKQERGEPAAEGPAPGPPISLDGSLSLGAEPGSLLFLQSAAAGL
GLALGDAGDPGPPDAAAPGPREGAAAAAAAAGESSQEDEEEELELPEEEAEDDEDEDDDEDDDDEDDDEDDDDEDLRTDSEESLPEAAAE

--------------------------------------------------------------
>In-frame_ENST00000422127_ENST00000344008_TCGA-BB-4223-01A_OBSCN_chr1_228412435_+_CASZ1_chr1_10725628_length(transcript)=7042nt_BP=2973nt
GCTGCCCAGAGCCCCCATAGAGAGAGGTCCCCGCCGCCACCCTCATGGATCAGCCACAGTTCAGCGGGGCGCCCCGCTTTCTCACCCGGC
CCAAGGCCTTCGTGGTGTCGGTGGGCAAGGACGCCACCCTCAGCTGCCAGATCGTGGGTAATCCCACGCCACAGGTGAGCTGGGAGAAGG
ACCAGCAGCCGGTGGCGGCCGGCGCGCGCTTCCGTCTGGCCCAGGACGGCGACCTCTACCGCCTCACTATCCTGGACCTGGCGCTGGGCG
ACAGTGGGCAATACGTGTGCCGCGCGCGCAATGCCATAGGCGAGGCCTTCGCTGCTGTGGGCCTGCAGGTGGACGCGGAGGCCGCGTGCG
CCGAGCAGGCGCCGCACTTCCTGCTGCGGCCCACGTCCATCCGCGTGCGCGAGGGCTCAGAGGCCACCTTCCGCTGCCGCGTGGGTGGCT
CCCCGAGGCCGGCAGTGAGCTGGTCCAAGGACGGGCGGCGCCTGGGTGAGCCCGACGGCCCCCGCGTGCGCGTGGAGGAGCTCGGCGAGG
CAAGTGCGCTGCGCATTCGGGCGGCGCGGCCGCGCGACGGCGGCACTTACGAGGTCCGCGCCGAGAACCCGCTGGGCGCTGCCAGCGCCG
CCGCGGCGCTAGTGGTGGACTCGGACGCCGCGGACACGGCCAGCCGGCCCGGGACCTCCACGGCCGCGCTCCTGGCGCACCTGCAGCGGC
GGCGCGAGGCTATGCGCGCCGAGGGCGCCCCCGCCTCACCGCCCAGCACCGGCACGCGCACCTGCACGGTGACTGAAGGCAAGCACGCGC
GCCTCAGCTGCTACGTGACCGGCGAGCCCAAGCCCGAGACGGTGTGGAAGAAGGACGGCCAGCTGGTGACCGAGGGCCGGCGCCACGTGG
TGTACGAGGACGCGCAGGAGAACTTCGTGCTCAAGATCCTCTTCTGCAAGCAGTCGGACCGCGGCCTCTACACCTGCACGGCGTCCAACC
TCGTGGGCCAGACCTACAGCTCTGTGCTGGTCGTAGTGCGCGAGCCCGCGGTTCCCTTCAAAAAGCGGCTGCAAGATCTGGAGGTGCGGG
AGAAGGAGTCGGCCACGTTCCTATGTGAGGTGCCCCAGCCGTCCACTGAGGCCGCGTGGTTCAAGGAGGAGACGCGGTTGTGGGCGAGCG
CCAAGTACGGCATCGAGGAGGAGGGCACCGAGCGCCGCCTGACCGTGCGCAATGTCTCGGCCGACGACGACGCGGTGTACATCTGCGAGA
CGCCAGAGGGCAGCCGCACGGTGGCGGAGCTCGCAGTCCAAGGAAACCTCCTCCGAAAGCTCCCTCGGAAGACGGCGGTGCGCGTGGGCG
ACACGGCTATGTTTTGCGTGGAGCTGGCGGTCCCGGTGGGCCCCGTCCACTGGCTGCGGAACCAGGAGGAAGTGGTGGCGGGGGGCCGCG
TGGCCATCTCCGCGGAGGGCACGCGCCACACACTAACCATCTCCCAGTGCTGCCTGGAGGATGTGGGCCAGGTGGCCTTTATGGCTGGCG
ACTGCCAGACGTCCACCCAGTTCTGCGTGTCGGCCCCCAGGAAGCCTCCCCTGCAACCCCCTGTGGATCCTGTGGTAAAGGCCAGGATGG
AGAGTTCCGTGATTCTCAGCTGGTCCCCACCACCCCATGGGGAACGCCCTGTCACTATCGACGGCTACCTGGTAGAGAAGAAGAAGCTTG
GCACCTACACCTGGATCAGGTGCCACGAGGCTGAATGGGTGGCTACACCTGAGCTGACCGTGGCTGATGTGGCGGAGGAGGGGAACTTCC
AGTTCCGAGTGTCCGCTCTCAACAGCTTTGGTCAGAGTCCCTACCTCGAGTTCCCGGGGACTGTCCACCTGGCCCCCAAGCTGGCCGTGA
GGACACCGCTGAAGGCGGTGCAGGCGGTAGAGGGTGGCGAGGTCACTTTCTCCGTGGACCTCACGGTGGCCTCAGCGGGTGAGTGGTTCC
TGGATGGGCAGGCCCTGAAGGCCAGCAGTGTGTATGAGATCCACTGTGATCGCACCCGGCACACGCTCACCATCCGGGAGGTGCCCGCCA
GCCTGCACGGGGCGCAGCTGAAGTTCGTGGCCAACGGCATTGAGAGCAGCATCCGGATGGAGGTCCGGGCGGCCCCAGGGCTGACTGCCA
ACAAGCCGCCAGCCGCAGCTGCCCGGGAGGTGCTGGCTCGGCTGCACGAGGAGGCGCAGCTGCTGGCTGAGCTGTCAGATCAGGCTGCGG
CTGTGACGTGGCTGAAGGATGGTCGCACACTGTCCCCAGGCCCCAAGTATGAGGTGCAGGCATCGGCCGGGCGGCGGGTGCTCCTTGTGC
GAGATGTGGCCCGGGACGATGCAGGCCTCTACGAGTGCGTCAGCCGCGGGGGCCGCATCGCCTACCAGCTCTCCGTGCAAGGCCTCGCGC
GCTTTCTGCACAAGGACATGGCGGGCAGCTGTGTGGATGCCGTGGCTGGGGGCCCGGCGCAGTTTGAGTGTGAGACCTCCGAAGCCCACG
TCCACGTGCACTGGTACAAGGATGGCATGGAGCTGGGCCACTCCGGTGAGCGCTTCTTGCAGGAGGATGTGGGGACGCGGCACCGGCTGG
TGGCAGCCACAGTCACCAGGCAGGATGAAGGCACCTACTCCTGCCGCGTGGGCGAGGACTCTGTGGACTTCCGGCTCCGCGTCTCTGAGC
CCAAGGTGGTGTTTGCTAAGGAGCAGCTGGCACGCAGGAAGCTGCAGGCAGAGGCAGGAGCCAGTGCCACACTGAGCTGCGAGGTGGCCC
AGGCCCAGACGGAGGTGACGTGGTACAAGGATGGGAAGAAGCTGAGCTCCAGCTCGAAAGTGTGCATGGAGGCCACAGGCTGCACGCGCA
GGCTGGTTGTGCAGCAGGCAGGCCAGGCGGATGCCGGGGAGTATAGCTGCGAGGCTGGGGGCCAGCGGCTCTCCTTCCATCTGGATGTCA
AAGCTGAGGGCACCCGGTGCACGGACCCGCCTGCAGGCAAGCCCGCCATGGCGCCCAAACGCAAGGGTGGCCTGAAGCTGAACGCCATCT
GCGCCAAGCTGAGCCGCCAGGTGGTGGTGGAGAAGCGAGCTGACGCCGGCTCCCACACGGAGGGCAGCCCATCGCAGCCCCGGGACCAAG
AGCGCAGTGGCCCTGAGTCTGGGGCAGCCCGGGCCCCCCGCAGCGAGGAAGACAAGAGACGGGCAGTGATCGAGAAGTGGGTGAACGGGG
AGTACAGCGAGGAGCCGGCACCCACACCCGTGTTGGGGCGGATTGCCCGCGAGGGCCTGGAGCTGCCTCCCGAGGGTGTCTACATGGTGC
AGCCCCAGGGGTGCAGCGATGAGGAAGACCACGCGGAGGAGCCCTCCAAGGACGGCGGTGCCCTGGAGGAGAAGGATTCGGACGGGGCAG
CCTCCAAGGAGGACAGCGGCCCCAGCACCAGGCAGGCTTCAGGAGAGGCCTCCTCGCTGCGGGACTACGCGGCCTCCACCATGACCGAGT
TCCTCGGCATGTTTGGCTATGATGACCAGAACACGCGGGACGAGCTGGCCAGGAAGATCAGCTTTGAGAAGCTGCACGCGGGCTCCACCC
CGGAGGCAGCCACCTCCTCCATGCTGCCCACCTCCGAGGATACCCTCAGCAAGCGGGCGCGGTTCTCTAAGTATGAGGAGTACATCCGCA
AGCTCAAGGCTGGCGAGCAGCTCTCCTGGCCGGCCCCCAGCACCAAGACCGAGGAGCGGGTGGGCAAGGAGGTGGTGGGCACCCTGCCCG
GCCTGCGGCTGCCCAGCAGCACGGCCCACCTGGAGACCAAGGCCACCATCCTGCCCCTGCCGTCGCACAGCAGTGTCCAGATGCAGAACC
TGGTAGCCCGGGCCTCCAAGTACGACTTCTTCATCCAAAAACTGAAGACCGGCGAGAATCTGCGGCCCCAGAACGGGAGCACCTACAAGA
AGCCATCCAAGTACGACCTGGAGAATGTCAAGTACCTGCACCTCTTCAAACCCGGGGAGGGCAGCCCCGACATGGGCGGGGCCATCGCCT
TCAAGACAGGCAAGGTGGGGCGCCCTTCCAAGTACGACGTCCGGGGCATCCAGAAGCCAGGCCCCGCCAAGGTTCCGCCCACCCCCAGCC
TGGCTCCCGCACCCCTCGCCAGCGTGCCCAGTGCCCCCAGCGCCCCCGGGCCAGGGCCAGAGCCTCCTGCCTCCCTGTCCTTCAACACTC
CCGAGTACCTGAAGTCAACCTTCTCCAAAACAGACTCCATCACCACGGGGACCGTCTCCACTGTCAAGAACGGACTGCCCACAGATAAAC
CAGCCGTCACTGAAGATGTAAACATTTACCAGAAATATATTGCCAGGTTCTCGGGCAGCCAGCACTGTGGCCACATCCACTGTGCCTACC
AGTACCGCGAGCACTACCACTGCCTTGACCCTGAGTGTAACTACCAGAGGTTCACGAGTAAGCAGGACGTGATCCGCCACTACAACATGC
ACAAGAAGCGCGACAACTCCCTGCAGCACGGCTTCATGCGTTTCAGCCCGCTGGACGACTGCAGCGTCTACTACCACGGCTGCCACCTCA
ATGGGAAGAGCACCCACTATCACTGCATGCAGGTGGGCTGTAACAAGGTGTACACGAGCACGTCTGACGTGATGACCCACGAGAACTTCC
ACAAGAAGAATACCCAGCTCATTAACGACGGCTTCCAGCGCTTCCGAGCCACCGAAGACTGTGGCACAGCCGACTGCCAGTTCTACGGAC
AGAAGACCACGCACTTCCACTGCAGGCGCCCCGGCTGCACATTCACTTTCAAGAACAAGTGTGACATCGAGAAGCACAAGAGCTACCACA
TCAAGGACGATGCCTACGCCAAGGACGGCTTCAAGAAGTTCTACAAGTACGAGGAGTGCAAGTACGAGGGCTGCGTGTACAGCAAGGCTA
CCAACCACTTCCACTGCATCCGCGCCGGCTGCGGCTTCACCTTCACCTCCACCAGCCAGATGACCTCTCACAAGCGCAAGCATGAGCGCC
GGCACATCCGCTCCTCGGGCGCGCTGGGGCTGCCGCCCTCGCTGCTGGGCGCCAAGGACACGGAGCACGAGGAGTCCAGCAACGACGACC
TTGTTGACTTCTCCGCCCTGAGCAGCAAGAACTCCAGCCTGAGCGCCTCCCCTACCAGCCAGCAGTCCTCTGCGTCCCTGGCTGCCGCCA
CTGCCGCCACCGAGGCTGGGCCCAGTGCCACCAAACCTCCCAACAGCAAGATCTCGGGGCTGCTGCCCCAGGGCCTGCCTGGCTCAATCC
CCCTGGCCCTGGCCCTCTCCAACTCGGGCCTGCCCACCCCCACGCCCTACTTCCCCATACTGGCTGGCCGTGGGAGCACCTCCCTGCCTG
TGGGCACCCCCAGCCTCCTGGGTGCCGTGTCGTCTGGGTCAGCAGCCTCAGCCACCCCTGACACACCCACGCTGGTCGCCTCGGGAGCTG
GAGACTCAGCCCCCGTGGCTGCCGCCTCTGTCCCGGCACCACCCGCCTCCATCATGGAGAGGATCTCTGCAAGCAAGGGCCTCATCTCGC
CCATGATGGCCAGGCTGGCTGCAGCTGCCCTCAAGCCCTCTGCCACCTTTGACCCAGGAAGCGGGCAGCAGGTCACCCCAGCCAGGTTCC
CCCCGGCCCAAGTGAAGCCGGAACCCGGTGAGAGCACCGGCGCCCCAGGCCCCCACGAAGCCTCCCAGGACCGCAGTCTAGACCTGACTG
TGAAGGAGCCCAGCAACGAATCAAATGGCCACGCAGTCCCGGCAAATTCATCTCTTTTATCCTCGCTTATGAATAAGATGTCTCAGGGCA
ACCCTGGCCTGGGCAGCCTGCTGAACATCAAGGCGGAAGCGGAGGGGAGCCCCGCTGCGGAGCCCTCGCCCTTCCTAGGCAAGGCCGTGA
AGGCGCTGGTTCAGGAGAAGTTGGCAGAGCCCTGGAAGGTGTACCTGCGCAGGTTTGGTACAAAGGACTTCTGTGACGGCCAGTGTGACT
TCCTCCACAAGGCCCACTTCCACTGCGTGGTGGAGGAATGCGGCGCGCTCTTCAGCACCTTGGACGGGGCCATCAAGCACGCAAACTTCC
ACTTCCGGACAGAGGGAGGAGCAGCAAAAGGAAACACAGAGGCTGCCTTTCCGGCCTCGGCCGCCGAGACCAAACCTCCCATGGCCCCCT
CGTCCCCTCCGGTCCCTCCTGTCACCACGGCCACGGTGTCCTCTCTGGAGGGGCCCGCTCCCAGCCCGGCCTCCGTGCCCTCCACCCCCA
CCCTGCTCGCCTGGAAGCAGCTGGCTTCCACCATACCCCAGATGCCTCAGATCCCAGCGTCAGTGCCTCACCTGCCCGCCTCGCCCTTGG
CAACGACTTCTCTAGAGAACGCCAAGCCCCAGGTCAAACCCGGATTCCTCCAGTTCCAGGAGAAGTGAGTCCCTCGATGAGCCGGGAGTC
CCGCGTTCCCCTCGCGTCTCGGGAGTAGGTGCTAGCAAGGGCGCTAGGAGGCCCTGTTCCTCACTGCGGATGGTGCTGCTGTCCCCAGCC
TCTCTGGGGCATGGCCATCGGGTGATGTCCTTCTAGCCAAAGATGCTGCTGCTCCTACCTCACTGCCTGTCCCAGAGCAGGCCAGCCCGC
GTGGGCCGATGGTGGCGGCAGTGGCTACTGCTCCTGCAGGGCATGTGGTGATCCTGCCAGGGCCAGGTGGGGTGGACTGGGCGTGGTGGT
CCTCAGAGGACAACTCCCAGCCTGACAAGGAGGGCTGCGTCTCCCTCCGAGCCTCCGTATTGGCCTCCTCTGTGGCTCACACCCATGGCT
GAATCTCTGCAGGGCACGTGAAGTCACGGGTAGGGGCCAGGCCCCTCCAGGCCGTCACTGGCCTGCACAGTGGTCTGAGCTCTTGGGTGG
AAGGGACCCTCCTCACTGGATGGTGGTGGCTCCTTGCAGGGAGAACGGTGACTTTGTATTGTCATGTGTGCGGCTTCCTGTTCTCAATAA

>In-frame_ENST00000422127_ENST00000344008_TCGA-BB-4223-01A_OBSCN_chr1_228412435_+_CASZ1_chr1_10725628_length(amino acids)=2137AA_start in transcript=44_stop in transcript=6457
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGE
AFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG
TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV
WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPS
TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGE
RPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEV
TFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARL
HEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAV
AGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAKEQLARRKL
QAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKAEGTRCTDPPAGKP
AMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLGRI
AREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAASTMTEFLGMFGYDDQNTRDE
LARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLETKA
TILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMGGAIAFKTGKVGRPSKYDVR
GIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIA
RFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYHGCHLNGKSTHYHCMQVGCN
KVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFY
KYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEESSNDDLVDFSALSSKNSSLS
ASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSGSA
ASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVTPARFPPAQVKPEPGESTGA
PGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWKVY
LRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKPPMAPSSPPVPPVTTATVSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for OBSCN-CASZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OBSCN-CASZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OBSCN-CASZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOBSCNC0007194Hypertrophic Cardiomyopathy4CLINGEN
TgeneCASZ1C0004238Atrial Fibrillation2CTD_human
TgeneCASZ1C0235480Paroxysmal atrial fibrillation2CTD_human
TgeneCASZ1C2585653Persistent atrial fibrillation2CTD_human
TgeneCASZ1C3468561familial atrial fibrillation2CTD_human
TgeneCASZ1C0033578Prostatic Neoplasms1CTD_human
TgeneCASZ1C0038454Cerebrovascular accident1CTD_human
TgeneCASZ1C0376358Malignant neoplasm of prostate1CTD_human
TgeneCASZ1C0751956Acute Cerebrovascular Accidents1CTD_human