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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OCLN-CCNB1 (FusionGDB2 ID:60940)

Fusion Gene Summary for OCLN-CCNB1

check button Fusion gene summary
Fusion gene informationFusion gene name: OCLN-CCNB1
Fusion gene ID: 60940
HgeneTgene
Gene symbol

OCLN

CCNB1

Gene ID

100506658

891

Gene nameoccludincyclin B1
SynonymsBLCPMG|PPP1R115|PTORCH1CCNB
Cytomap

5q13.2

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionoccludinphosphatase 1, regulatory subunit 115tight junction protein occludinG2/mitotic-specific cyclin-B1
Modification date2020031320200313
UniProtAcc.

Q9NPC3

Ensembl transtripts involved in fusion geneENST00000355237, ENST00000396442, 
ENST00000380766, ENST00000538151, 
ENST00000542132, ENST00000514370, 
ENST00000256442, 
Fusion gene scores* DoF score9 X 6 X 7=3787 X 7 X 5=245
# samples 137
** MAII scorelog2(13/378*10)=-1.53987461119262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OCLN [Title/Abstract] AND CCNB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOCLN(68809936)-CCNB1(68467097), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCNB1

GO:0010971

positive regulation of G2/M transition of mitotic cell cycle

24746669

TgeneCCNB1

GO:1905448

positive regulation of mitochondrial ATP synthesis coupled electron transport

24746669


check buttonFusion gene breakpoints across OCLN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCNB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-2F-A9KP-01AOCLNchr5

68809936

-CCNB1chr5

68467097

+


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Fusion Gene ORF analysis for OCLN-CCNB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000355237ENST00000256442OCLNchr5

68809936

-CCNB1chr5

68467097

+
In-frameENST00000396442ENST00000256442OCLNchr5

68809936

-CCNB1chr5

68467097

+
intron-3CDSENST00000380766ENST00000256442OCLNchr5

68809936

-CCNB1chr5

68467097

+
In-frameENST00000538151ENST00000256442OCLNchr5

68809936

-CCNB1chr5

68467097

+
intron-3CDSENST00000542132ENST00000256442OCLNchr5

68809936

-CCNB1chr5

68467097

+
intron-3CDSENST00000514370ENST00000256442OCLNchr5

68809936

-CCNB1chr5

68467097

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355237OCLNchr568809936-ENST00000256442CCNB1chr568467097+288013274362265609
ENST00000396442OCLNchr568809936-ENST00000256442CCNB1chr568467097+262310701792008609
ENST00000538151OCLNchr568809936-ENST00000256442CCNB1chr568467097+18092561091194361

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355237ENST00000256442OCLNchr568809936-CCNB1chr568467097+0.0010075070.9989925
ENST00000396442ENST00000256442OCLNchr568809936-CCNB1chr568467097+0.0008284150.9991716
ENST00000538151ENST00000256442OCLNchr568809936-CCNB1chr568467097+0.0005082850.9994917

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Fusion Genomic Features for OCLN-CCNB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for OCLN-CCNB1


check button Go to

FGviewer for the breakpoints of chr5:68809936-chr5:68467097

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCNB1

Q9NPC3

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. {ECO:0000250, ECO:0000269|PubMed:12612082, ECO:0000269|PubMed:17297447}.; FUNCTION: E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOCLNchr5:68809936chr5:68467097ENST00000355237-4992_131297.0523.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:68467097ENST00000396442-4992_131297.0523.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:68467097ENST00000355237-4960_269297.0523.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:68467097ENST00000396442-4960_269297.0523.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:68467097ENST00000355237-49161_170297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000355237-49196_243297.0523.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:68467097ENST00000355237-491_66297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000355237-4990_135297.0523.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:68467097ENST00000396442-49161_170297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000396442-49196_243297.0523.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:68467097ENST00000396442-491_66297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000396442-4990_135297.0523.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:68467097ENST00000355237-49136_160297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000355237-49171_195297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000355237-49244_265297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000355237-4967_89297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000396442-49136_160297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000396442-49171_195297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000396442-49244_265297.0523.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000396442-4967_89297.0523.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOCLNchr5:68809936chr5:68467097ENST00000355237-49426_489297.0523.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:68467097ENST00000380766-18426_4890469.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:68467097ENST00000396442-49426_489297.0523.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:68467097ENST00000538151-27426_48946.0272.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:68467097ENST00000542132-16426_4890201.0Coiled coilOntology_term=ECO:0000255
HgeneOCLNchr5:68809936chr5:68467097ENST00000380766-1892_1310469.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:68467097ENST00000538151-2792_13146.0272.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:68467097ENST00000542132-1692_1310201.0Compositional biasNote=Gly/Tyr-rich
HgeneOCLNchr5:68809936chr5:68467097ENST00000380766-1860_2690469.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:68467097ENST00000538151-2760_26946.0272.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:68467097ENST00000542132-1660_2690201.0DomainMARVEL
HgeneOCLNchr5:68809936chr5:68467097ENST00000355237-49266_522297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000380766-18161_1700469.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000380766-18196_2430469.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:68467097ENST00000380766-181_660469.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000380766-18266_5220469.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000380766-1890_1350469.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:68467097ENST00000396442-49266_522297.0523.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000538151-27161_17046.0272.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000538151-27196_24346.0272.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:68467097ENST00000538151-271_6646.0272.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000538151-27266_52246.0272.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000538151-2790_13546.0272.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:68467097ENST00000542132-16161_1700201.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000542132-16196_2430201.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:68467097ENST00000542132-161_660201.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000542132-16266_5220201.0Topological domainCytoplasmic
HgeneOCLNchr5:68809936chr5:68467097ENST00000542132-1690_1350201.0Topological domainExtracellular
HgeneOCLNchr5:68809936chr5:68467097ENST00000380766-18136_1600469.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000380766-18171_1950469.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000380766-18244_2650469.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000380766-1867_890469.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000538151-27136_16046.0272.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000538151-27171_19546.0272.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000538151-27244_26546.0272.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000538151-2767_8946.0272.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000542132-16136_1600201.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000542132-16171_1950201.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000542132-16244_2650201.0TransmembraneHelical
HgeneOCLNchr5:68809936chr5:68467097ENST00000542132-1667_890201.0TransmembraneHelical
TgeneCCNB1chr5:68809936chr5:68467097ENST000002564422951_85121.0434.0Compositional biasNote=Lys-rich


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Fusion Gene Sequence for OCLN-CCNB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000355237_ENST00000256442_TCGA-2F-A9KP-01A_OCLN_chr5_68809936_-_CCNB1_chr5_68467097_length(transcript)=2880nt_BP=1327nt
GCCTCTCTCCATCAGACACCCCAAGGTTCCATCCGAAGCAGGCGGAGCACCGAACGCACCCCGGGGTGGTCAGGGACCCCCATCCGTGCT
GCCCCCTAGGAGCCCGCGCCTCTCCTCTGCGCCCCGCCTCTCGGGCCGCAACGTCGCGCGGTTCCTTTAACAGCGCGCTGGCAGGGTGTG
GGAAGCAGGACCGCGTCCTCCCGCCCCCTCCCATCCGAGTTTCAGGTGAATTGGTCACCGAGGGAGGAGGCCGACACACCACACCTACAC
TCCCGCGTCCACCTCTCCCTCCCTGCTTCCTCTGGCGGAGGCGGCAGGAACCGAGAGCCAGGTCCAGAGCGCCGAGGAGCCGGTCTAGGA
CGCAGCAGATTGGTTTATCTTGGAAGCTAAAGGGCATTGCTCATCCTGAAGATCAGCTGACCATTGACAATCAGCCATGTCATCCAGGCC
TCTTGAAAGTCCACCTCCTTACAGGCCTGATGAATTCAAACCGAATCATTATGCACCAAGCAATGACATATATGGTGGAGAGATGCATGT
TCGACCAATGCTCTCTCAGCCAGCCTACTCTTTTTACCCAGAAGATGAAATTCTTCACTTCTACAAATGGACCTCTCCTCCAGGAGTGAT
TCGGATCCTGTCTATGCTCATTATTGTGATGTGCATTGCCATCTTTGCCTGTGTGGCCTCCACGCTTGCCTGGGACAGAGGCTATGGAAC
TTCCCTTTTAGGAGGTAGTGTAGGCTACCCTTATGGAGGAAGTGGCTTTGGTAGCTACGGAAGTGGCTATGGCTATGGCTATGGTTATGG
CTATGGCTACGGAGGCTATACAGACCCAAGAGCAGCAAAGGGCTTCATGTTGGCCATGGCTGCCTTTTGTTTCATTGCCGCGTTGGTGAT
CTTTGTTACCAGTGTTATAAGATCTGAAATGTCCAGAACAAGAAGATACTACTTAAGTGTGATAATAGTGAGTGCTATCCTGGGCATCAT
GGTGTTTATTGCCACAATTGTCTATATAATGGGAGTGAACCCAACTGCTCAGTCTTCTGGATCTCTATATGGTTCACAAATATATGCCCT
CTGCAACCAATTTTATACACCTGCAGCTACTGGACTCTACGTGGATCAGTATTTGTATCACTACTGTGTTGTGGATCCCCAGGAGGCCAT
TGCCATTGTACTGGGGTTCATGATTATTGTGGCTTTTGCTTTAATAATTTTCTTTGCTGTGAAAACTCGAAGAAAGATGGACAGGTATGA
CAAGTCCAATATTTTGTGGGACAAGGAACACATTTATGATGAGCAGCCCCCCAATGTCGAGGAGTGGGTTGATACTGCCTCTCCAAGCCC
AATGGAAACATCTGGATGTGCCCCTGCAGAAGAAGACCTGTGTCAGGCTTTCTCTGATGTAATTCTTGCAGTAAATGATGTGGATGCAGA
AGATGGAGCTGATCCAAACCTTTGTAGTGAATATGTGAAAGATATTTATGCTTATCTGAGACAACTTGAGGAAGAGCAAGCAGTCAGACC
AAAATACCTACTGGGTCGGGAAGTCACTGGAAACATGAGAGCCATCCTAATTGACTGGCTAGTACAGGTTCAAATGAAATTCAGGTTGTT
GCAGGAGACCATGTACATGACTGTCTCCATTATTGATCGGTTCATGCAGAATAATTGTGTGCCCAAGAAGATGCTGCAGCTGGTTGGTGT
CACTGCCATGTTTATTGCAAGCAAATATGAAGAAATGTACCCTCCAGAAATTGGTGACTTTGCTTTTGTGACTGACAACACTTATACTAA
GCACCAAATCAGACAGATGGAAATGAAGATTCTAAGAGCTTTAAACTTTGGTCTGGGTCGGCCTCTACCTTTGCACTTCCTTCGGAGAGC
ATCTAAGATTGGAGAGGTTGATGTCGAGCAACATACTTTGGCCAAATACCTGATGGAACTAACTATGTTGGACTATGACATGGTGCACTT
TCCTCCTTCTCAAATTGCAGCAGGAGCTTTTTGCTTAGCACTGAAAATTCTGGATAATGGTGAATGGACACCAACTCTACAACATTACCT
GTCATATACTGAAGAATCTCTTCTTCCAGTTATGCAGCACCTGGCTAAGAATGTAGTCATGGTAAATCAAGGACTTACAAAGCACATGAC
TGTCAAGAACAAGTATGCCACATCGAAGCATGCTAAGATCAGCACTCTACCACAGCTGAATTCTGCACTAGTTCAAGATTTAGCCAAGGC
TGTGGCAAAGGTGTAACTTGTAAACTTGAGTTGGAGTACTATATTTACAAATAAAATTGGCACCATGTGCCATCTGTACATATTACTGTT
GCATTTACTTTTAATAAAGCTTGTGGCCCCTTTTACTTTTTTATAGCTTAACTAATTTGAATGTGGTTACTTCCTACTGTAGGGTAGCGG
AAAAGTTGTCTTAAAAGGTATGGTGGGGATATTTTTAAAAACTCCTTTTGGTTTACCTGGGGATCCAATTGATGTATATGTTTATATACT
GGGTTCTTGTTTTATATACCTGGCTTTTACTTTATTAATATGAGTTACTGAAGGTGATGGAGGTATTTGAAAATTTTACTTCCATAGGAC
ATACTGCATGTAAGCCAAGTCATGGAGAATCTGCTGCATAGCTCTATTTTAAAGTAAAAGTCTACCACCGAATCCCTAGTCCCCCTGTTT
TCTGTTTCTTCTTGTGATTGCTGCCATAATTCTAAGTTATTTACTTTTACCACTATTTAAGTTATCAACTTTAGCTAGTATCTTCAAACT
TTCACTTTGAAAAATGAGAATTTTATATTCTAAGCCAGTTTTCATTTTGGTTTTGTGTTTTGGTTAATAAAACAATACTCAAATACAAAA

>In-frame_ENST00000355237_ENST00000256442_TCGA-2F-A9KP-01A_OCLN_chr5_68809936_-_CCNB1_chr5_68467097_length(amino acids)=609AA_start in transcript=436_stop in transcript=2265
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWD
RGYGTSLLGGSVGYPYGGSGFGSYGSGYGYGYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA
ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRK
MDRYDKSNILWDKEHIYDEQPPNVEEWVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEE
QAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTD
NTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPT

--------------------------------------------------------------
>In-frame_ENST00000396442_ENST00000256442_TCGA-2F-A9KP-01A_OCLN_chr5_68809936_-_CCNB1_chr5_68467097_length(transcript)=2623nt_BP=1070nt
AGTCCCCGGCTGAGCGCTGGCGGTCGGTGCGGCGTCAGGTGCGCCCGCCAGGTGAGCGCGCTCCCTGGCACCGTTGGCCCCCGGAGGGTC
GGGCCCAGTTGCGGCGAGCGGATTGGTTTATCTTGGAAGCTAAAGGGCATTGCTCATCCTGAAGATCAGCTGACCATTGACAATCAGCCA
TGTCATCCAGGCCTCTTGAAAGTCCACCTCCTTACAGGCCTGATGAATTCAAACCGAATCATTATGCACCAAGCAATGACATATATGGTG
GAGAGATGCATGTTCGACCAATGCTCTCTCAGCCAGCCTACTCTTTTTACCCAGAAGATGAAATTCTTCACTTCTACAAATGGACCTCTC
CTCCAGGAGTGATTCGGATCCTGTCTATGCTCATTATTGTGATGTGCATTGCCATCTTTGCCTGTGTGGCCTCCACGCTTGCCTGGGACA
GAGGCTATGGAACTTCCCTTTTAGGAGGTAGTGTAGGCTACCCTTATGGAGGAAGTGGCTTTGGTAGCTACGGAAGTGGCTATGGCTATG
GCTATGGTTATGGCTATGGCTACGGAGGCTATACAGACCCAAGAGCAGCAAAGGGCTTCATGTTGGCCATGGCTGCCTTTTGTTTCATTG
CCGCGTTGGTGATCTTTGTTACCAGTGTTATAAGATCTGAAATGTCCAGAACAAGAAGATACTACTTAAGTGTGATAATAGTGAGTGCTA
TCCTGGGCATCATGGTGTTTATTGCCACAATTGTCTATATAATGGGAGTGAACCCAACTGCTCAGTCTTCTGGATCTCTATATGGTTCAC
AAATATATGCCCTCTGCAACCAATTTTATACACCTGCAGCTACTGGACTCTACGTGGATCAGTATTTGTATCACTACTGTGTTGTGGATC
CCCAGGAGGCCATTGCCATTGTACTGGGGTTCATGATTATTGTGGCTTTTGCTTTAATAATTTTCTTTGCTGTGAAAACTCGAAGAAAGA
TGGACAGGTATGACAAGTCCAATATTTTGTGGGACAAGGAACACATTTATGATGAGCAGCCCCCCAATGTCGAGGAGTGGGTTGATACTG
CCTCTCCAAGCCCAATGGAAACATCTGGATGTGCCCCTGCAGAAGAAGACCTGTGTCAGGCTTTCTCTGATGTAATTCTTGCAGTAAATG
ATGTGGATGCAGAAGATGGAGCTGATCCAAACCTTTGTAGTGAATATGTGAAAGATATTTATGCTTATCTGAGACAACTTGAGGAAGAGC
AAGCAGTCAGACCAAAATACCTACTGGGTCGGGAAGTCACTGGAAACATGAGAGCCATCCTAATTGACTGGCTAGTACAGGTTCAAATGA
AATTCAGGTTGTTGCAGGAGACCATGTACATGACTGTCTCCATTATTGATCGGTTCATGCAGAATAATTGTGTGCCCAAGAAGATGCTGC
AGCTGGTTGGTGTCACTGCCATGTTTATTGCAAGCAAATATGAAGAAATGTACCCTCCAGAAATTGGTGACTTTGCTTTTGTGACTGACA
ACACTTATACTAAGCACCAAATCAGACAGATGGAAATGAAGATTCTAAGAGCTTTAAACTTTGGTCTGGGTCGGCCTCTACCTTTGCACT
TCCTTCGGAGAGCATCTAAGATTGGAGAGGTTGATGTCGAGCAACATACTTTGGCCAAATACCTGATGGAACTAACTATGTTGGACTATG
ACATGGTGCACTTTCCTCCTTCTCAAATTGCAGCAGGAGCTTTTTGCTTAGCACTGAAAATTCTGGATAATGGTGAATGGACACCAACTC
TACAACATTACCTGTCATATACTGAAGAATCTCTTCTTCCAGTTATGCAGCACCTGGCTAAGAATGTAGTCATGGTAAATCAAGGACTTA
CAAAGCACATGACTGTCAAGAACAAGTATGCCACATCGAAGCATGCTAAGATCAGCACTCTACCACAGCTGAATTCTGCACTAGTTCAAG
ATTTAGCCAAGGCTGTGGCAAAGGTGTAACTTGTAAACTTGAGTTGGAGTACTATATTTACAAATAAAATTGGCACCATGTGCCATCTGT
ACATATTACTGTTGCATTTACTTTTAATAAAGCTTGTGGCCCCTTTTACTTTTTTATAGCTTAACTAATTTGAATGTGGTTACTTCCTAC
TGTAGGGTAGCGGAAAAGTTGTCTTAAAAGGTATGGTGGGGATATTTTTAAAAACTCCTTTTGGTTTACCTGGGGATCCAATTGATGTAT
ATGTTTATATACTGGGTTCTTGTTTTATATACCTGGCTTTTACTTTATTAATATGAGTTACTGAAGGTGATGGAGGTATTTGAAAATTTT
ACTTCCATAGGACATACTGCATGTAAGCCAAGTCATGGAGAATCTGCTGCATAGCTCTATTTTAAAGTAAAAGTCTACCACCGAATCCCT
AGTCCCCCTGTTTTCTGTTTCTTCTTGTGATTGCTGCCATAATTCTAAGTTATTTACTTTTACCACTATTTAAGTTATCAACTTTAGCTA
GTATCTTCAAACTTTCACTTTGAAAAATGAGAATTTTATATTCTAAGCCAGTTTTCATTTTGGTTTTGTGTTTTGGTTAATAAAACAATA

>In-frame_ENST00000396442_ENST00000256442_TCGA-2F-A9KP-01A_OCLN_chr5_68809936_-_CCNB1_chr5_68467097_length(amino acids)=609AA_start in transcript=179_stop in transcript=2008
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWD
RGYGTSLLGGSVGYPYGGSGFGSYGSGYGYGYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA
ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRK
MDRYDKSNILWDKEHIYDEQPPNVEEWVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEE
QAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTD
NTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPT

--------------------------------------------------------------
>In-frame_ENST00000538151_ENST00000256442_TCGA-2F-A9KP-01A_OCLN_chr5_68809936_-_CCNB1_chr5_68467097_length(transcript)=1809nt_BP=256nt
GGCATTGCTCATCCTGAAGATCAGCTGACCATTGACAATCAGCCATGTCATCCAGGCCTCTTGAAAGTCCACCTCCTTACAGGCCTGATG
AATTGCCATTGCCATTGTACTGGGGTTCATGATTATTGTGGCTTTTGCTTTAATAATTTTCTTTGCTGTGAAAACTCGAAGAAAGATGGA
CAGGTATGACAAGTCCAATATTTTGTGGGACAAGGAACACATTTATGATGAGCAGCCCCCCAATGTCGAGGAGTGGGTTGATACTGCCTC
TCCAAGCCCAATGGAAACATCTGGATGTGCCCCTGCAGAAGAAGACCTGTGTCAGGCTTTCTCTGATGTAATTCTTGCAGTAAATGATGT
GGATGCAGAAGATGGAGCTGATCCAAACCTTTGTAGTGAATATGTGAAAGATATTTATGCTTATCTGAGACAACTTGAGGAAGAGCAAGC
AGTCAGACCAAAATACCTACTGGGTCGGGAAGTCACTGGAAACATGAGAGCCATCCTAATTGACTGGCTAGTACAGGTTCAAATGAAATT
CAGGTTGTTGCAGGAGACCATGTACATGACTGTCTCCATTATTGATCGGTTCATGCAGAATAATTGTGTGCCCAAGAAGATGCTGCAGCT
GGTTGGTGTCACTGCCATGTTTATTGCAAGCAAATATGAAGAAATGTACCCTCCAGAAATTGGTGACTTTGCTTTTGTGACTGACAACAC
TTATACTAAGCACCAAATCAGACAGATGGAAATGAAGATTCTAAGAGCTTTAAACTTTGGTCTGGGTCGGCCTCTACCTTTGCACTTCCT
TCGGAGAGCATCTAAGATTGGAGAGGTTGATGTCGAGCAACATACTTTGGCCAAATACCTGATGGAACTAACTATGTTGGACTATGACAT
GGTGCACTTTCCTCCTTCTCAAATTGCAGCAGGAGCTTTTTGCTTAGCACTGAAAATTCTGGATAATGGTGAATGGACACCAACTCTACA
ACATTACCTGTCATATACTGAAGAATCTCTTCTTCCAGTTATGCAGCACCTGGCTAAGAATGTAGTCATGGTAAATCAAGGACTTACAAA
GCACATGACTGTCAAGAACAAGTATGCCACATCGAAGCATGCTAAGATCAGCACTCTACCACAGCTGAATTCTGCACTAGTTCAAGATTT
AGCCAAGGCTGTGGCAAAGGTGTAACTTGTAAACTTGAGTTGGAGTACTATATTTACAAATAAAATTGGCACCATGTGCCATCTGTACAT
ATTACTGTTGCATTTACTTTTAATAAAGCTTGTGGCCCCTTTTACTTTTTTATAGCTTAACTAATTTGAATGTGGTTACTTCCTACTGTA
GGGTAGCGGAAAAGTTGTCTTAAAAGGTATGGTGGGGATATTTTTAAAAACTCCTTTTGGTTTACCTGGGGATCCAATTGATGTATATGT
TTATATACTGGGTTCTTGTTTTATATACCTGGCTTTTACTTTATTAATATGAGTTACTGAAGGTGATGGAGGTATTTGAAAATTTTACTT
CCATAGGACATACTGCATGTAAGCCAAGTCATGGAGAATCTGCTGCATAGCTCTATTTTAAAGTAAAAGTCTACCACCGAATCCCTAGTC
CCCCTGTTTTCTGTTTCTTCTTGTGATTGCTGCCATAATTCTAAGTTATTTACTTTTACCACTATTTAAGTTATCAACTTTAGCTAGTAT
CTTCAAACTTTCACTTTGAAAAATGAGAATTTTATATTCTAAGCCAGTTTTCATTTTGGTTTTGTGTTTTGGTTAATAAAACAATACTCA

>In-frame_ENST00000538151_ENST00000256442_TCGA-2F-A9KP-01A_OCLN_chr5_68809936_-_CCNB1_chr5_68467097_length(amino acids)=361AA_start in transcript=109_stop in transcript=1194
MGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGA
DPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAM
FIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPS
QIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAKAVAK

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Fusion Gene PPI Analysis for OCLN-CCNB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCCNB1chr5:68809936chr5:68467097ENST0000025644229169_177121.0434.0CDK2
TgeneCCNB1chr5:68809936chr5:68467097ENST0000025644229258_261121.0434.0CDK2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OCLN-CCNB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OCLN-CCNB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOCLNC0006142Malignant neoplasm of breast2CTD_human
HgeneOCLNC0678222Breast Carcinoma2CTD_human
HgeneOCLNC1257931Mammary Neoplasms, Human2CTD_human
HgeneOCLNC1458155Mammary Neoplasms2CTD_human
HgeneOCLNC3489725Pseudo-TORCH syndrome2GENOMICS_ENGLAND;ORPHANET
HgeneOCLNC4552078PSEUDO-TORCH SYNDROME 12CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneOCLNC4704874Mammary Carcinoma, Human2CTD_human
HgeneOCLNC0006826Malignant Neoplasms1CTD_human
HgeneOCLNC0007621Neoplastic Cell Transformation1CTD_human
HgeneOCLNC0019156Hepatic Veno-Occlusive Disease1CTD_human
HgeneOCLNC0022660Kidney Failure, Acute1CTD_human
HgeneOCLNC0027651Neoplasms1CTD_human
HgeneOCLNC0035309Retinal Diseases1CTD_human
HgeneOCLNC0038002Splenomegaly1CTD_human
HgeneOCLNC0086692Benign Neoplasm1CTD_human
HgeneOCLNC1565662Acute Kidney Insufficiency1CTD_human
HgeneOCLNC2609414Acute kidney injury1CTD_human
HgeneOCLNC2931662Baraitser Brett Piesowicz syndrome1ORPHANET
TgeneCCNB1C0032460Polycystic Ovary Syndrome1CTD_human
TgeneCCNB1C1136382Sclerocystic Ovaries1CTD_human
TgeneCCNB1C1168401Squamous cell carcinoma of the head and neck1CTD_human
TgeneCCNB1C2239176Liver carcinoma1CTD_human