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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ODF2-URM1 (FusionGDB2 ID:60960)

Fusion Gene Summary for ODF2-URM1

check button Fusion gene summary
Fusion gene informationFusion gene name: ODF2-URM1
Fusion gene ID: 60960
HgeneTgene
Gene symbol

ODF2

URM1

Gene ID

4957

81605

Gene nameouter dense fiber of sperm tails 2ubiquitin related modifier 1
SynonymsCT134|ODF2/1|ODF2/2|ODF84C9orf74
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionouter dense fiber protein 2cancer/testis antigen 134cenexin 1outer dense fiber of sperm tails, 84-kDsperm tail structural proteintestis tissue sperm-binding protein Li 51eubiquitin-related modifier 1ubiquitin-related modifier 1 homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000393533, ENST00000372814, 
ENST00000351030, ENST00000604420, 
ENST00000535026, ENST00000448249, 
ENST00000393527, ENST00000434106, 
ENST00000546203, ENST00000372791, 
ENST00000372807, ENST00000444119, 
ENST00000372853, ENST00000452446, 
ENST00000372850, ENST00000372847, 
ENST00000483206, 
Fusion gene scores* DoF score8 X 9 X 5=3606 X 5 X 5=150
# samples 108
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ODF2 [Title/Abstract] AND URM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointODF2(131222833)-URM1(131133598), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ODF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across URM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-LA-A7SW-01AODF2chr9

131222833

+URM1chr9

131133598

+


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Fusion Gene ORF analysis for ODF2-URM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000393533ENST00000372853ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000393533ENST00000452446ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000393533ENST00000372850ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000393533ENST00000372847ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000393533ENST00000483206ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000372814ENST00000372853ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000372814ENST00000452446ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000372814ENST00000372850ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000372814ENST00000372847ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000372814ENST00000483206ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000351030ENST00000372853ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000351030ENST00000452446ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000351030ENST00000372850ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000351030ENST00000372847ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000351030ENST00000483206ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000604420ENST00000372853ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000604420ENST00000452446ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000604420ENST00000372850ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000604420ENST00000372847ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000604420ENST00000483206ODF2chr9

131222833

+URM1chr9

131133598

+
5UTR-3CDSENST00000535026ENST00000372853ODF2chr9

131222833

+URM1chr9

131133598

+
5UTR-3CDSENST00000535026ENST00000452446ODF2chr9

131222833

+URM1chr9

131133598

+
5UTR-intronENST00000535026ENST00000372850ODF2chr9

131222833

+URM1chr9

131133598

+
5UTR-intronENST00000535026ENST00000372847ODF2chr9

131222833

+URM1chr9

131133598

+
5UTR-intronENST00000535026ENST00000483206ODF2chr9

131222833

+URM1chr9

131133598

+
5UTR-3CDSENST00000448249ENST00000372853ODF2chr9

131222833

+URM1chr9

131133598

+
5UTR-3CDSENST00000448249ENST00000452446ODF2chr9

131222833

+URM1chr9

131133598

+
5UTR-intronENST00000448249ENST00000372850ODF2chr9

131222833

+URM1chr9

131133598

+
5UTR-intronENST00000448249ENST00000372847ODF2chr9

131222833

+URM1chr9

131133598

+
5UTR-intronENST00000448249ENST00000483206ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000393527ENST00000372853ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000393527ENST00000452446ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000393527ENST00000372850ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000393527ENST00000372847ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000393527ENST00000483206ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000434106ENST00000372853ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000434106ENST00000452446ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000434106ENST00000372850ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000434106ENST00000372847ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000434106ENST00000483206ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000546203ENST00000372853ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000546203ENST00000452446ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000546203ENST00000372850ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000546203ENST00000372847ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000546203ENST00000483206ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000372791ENST00000372853ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000372791ENST00000452446ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000372791ENST00000372850ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000372791ENST00000372847ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000372791ENST00000483206ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000372807ENST00000372853ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000372807ENST00000452446ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000372807ENST00000372850ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000372807ENST00000372847ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000372807ENST00000483206ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000444119ENST00000372853ODF2chr9

131222833

+URM1chr9

131133598

+
intron-3CDSENST00000444119ENST00000452446ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000444119ENST00000372850ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000444119ENST00000372847ODF2chr9

131222833

+URM1chr9

131133598

+
intron-intronENST00000444119ENST00000483206ODF2chr9

131222833

+URM1chr9

131133598

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ODF2-URM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ODF2-URM1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ODF2-URM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ODF2-URM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ODF2-URM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ODF2-URM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneURM1C0024623Malignant neoplasm of stomach1CTD_human
TgeneURM1C0038356Stomach Neoplasms1CTD_human
TgeneURM1C0235874Disease Exacerbation1CTD_human
TgeneURM1C1708349Hereditary Diffuse Gastric Cancer1CTD_human