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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ARHGAP23-CCL18 (FusionGDB2 ID:6103) |
Fusion Gene Summary for ARHGAP23-CCL18 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ARHGAP23-CCL18 | Fusion gene ID: 6103 | Hgene | Tgene | Gene symbol | ARHGAP23 | CCL18 | Gene ID | 57636 | 6362 |
Gene name | Rho GTPase activating protein 23 | C-C motif chemokine ligand 18 | |
Synonyms | - | AMAC-1|AMAC1|CKb7|DC-CK1|DCCK1|MIP-4|PARC|SCYA18 | |
Cytomap | 17q12 | 17q12 | |
Type of gene | protein-coding | protein-coding | |
Description | rho GTPase-activating protein 23rho-type GTPase-activating protein 23 | C-C motif chemokine 18CC chemokine PARCCC chemokine ligand 18alternative macrophage activation-associated CC chemokine 1chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)chemokine (C-C), dendriticdendritic cell chemokine 1macropha | |
Modification date | 20200313 | 20200322 | |
UniProtAcc | Q9P227 | . | |
Ensembl transtripts involved in fusion gene | ENST00000431231, ENST00000437668, ENST00000582409, ENST00000443378, | ENST00000004921, | |
Fusion gene scores | * DoF score | 13 X 12 X 10=1560 | 3 X 2 X 3=18 |
# samples | 14 | 4 | |
** MAII score | log2(14/1560*10)=-3.47804729680464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ARHGAP23 [Title/Abstract] AND CCL18 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ARHGAP23(36623572)-CCL18(34397807), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across ARHGAP23 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across CCL18 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LGG | TCGA-TQ-A7RP-01A | ARHGAP23 | chr17 | 36623572 | + | CCL18 | chr17 | 34397807 | + |
ChimerDB4 | LGG | TCGA-TQ-A7RP-01A | ARHGAP23 | chr17 | 36623572 | - | CCL18 | chr17 | 34397807 | + |
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Fusion Gene ORF analysis for ARHGAP23-CCL18 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000431231 | ENST00000004921 | ARHGAP23 | chr17 | 36623572 | + | CCL18 | chr17 | 34397807 | + |
In-frame | ENST00000437668 | ENST00000004921 | ARHGAP23 | chr17 | 36623572 | + | CCL18 | chr17 | 34397807 | + |
intron-3CDS | ENST00000582409 | ENST00000004921 | ARHGAP23 | chr17 | 36623572 | + | CCL18 | chr17 | 34397807 | + |
In-frame | ENST00000443378 | ENST00000004921 | ARHGAP23 | chr17 | 36623572 | + | CCL18 | chr17 | 34397807 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000431231 | ARHGAP23 | chr17 | 36623572 | + | ENST00000004921 | CCL18 | chr17 | 34397807 | + | 2910 | 1716 | 17 | 1918 | 633 |
ENST00000437668 | ARHGAP23 | chr17 | 36623572 | + | ENST00000004921 | CCL18 | chr17 | 34397807 | + | 2842 | 1648 | 0 | 1850 | 616 |
ENST00000443378 | ARHGAP23 | chr17 | 36623572 | + | ENST00000004921 | CCL18 | chr17 | 34397807 | + | 3222 | 2028 | 425 | 2230 | 601 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000431231 | ENST00000004921 | ARHGAP23 | chr17 | 36623572 | + | CCL18 | chr17 | 34397807 | + | 0.014266422 | 0.9857336 |
ENST00000437668 | ENST00000004921 | ARHGAP23 | chr17 | 36623572 | + | CCL18 | chr17 | 34397807 | + | 0.013280029 | 0.98672 |
ENST00000443378 | ENST00000004921 | ARHGAP23 | chr17 | 36623572 | + | CCL18 | chr17 | 34397807 | + | 0.011538316 | 0.98846173 |
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Fusion Genomic Features for ARHGAP23-CCL18 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ARHGAP23 | chr17 | 36623572 | + | CCL18 | chr17 | 34397806 | + | 0.01729131 | 0.9827087 |
ARHGAP23 | chr17 | 36623572 | + | CCL18 | chr17 | 34397806 | + | 0.01729131 | 0.9827087 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ARHGAP23-CCL18 |
Go to FGviewer for the breakpoints of chr17:36623572-chr17:34397807 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ARHGAP23 | . |
FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ARHGAP23 | chr17:36623572 | chr17:34397807 | ENST00000431231 | + | 7 | 24 | 183_279 | 549.3333333333334 | 1492.0 | Compositional bias | Note=Pro-rich |
Hgene | ARHGAP23 | chr17:36623572 | chr17:34397807 | ENST00000437668 | + | 7 | 25 | 183_279 | 549.3333333333334 | 1145.0 | Compositional bias | Note=Pro-rich |
Hgene | ARHGAP23 | chr17:36623572 | chr17:34397807 | ENST00000431231 | + | 7 | 24 | 71_155 | 549.3333333333334 | 1492.0 | Domain | PDZ |
Hgene | ARHGAP23 | chr17:36623572 | chr17:34397807 | ENST00000437668 | + | 7 | 25 | 71_155 | 549.3333333333334 | 1145.0 | Domain | PDZ |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ARHGAP23 | chr17:36623572 | chr17:34397807 | ENST00000431231 | + | 7 | 24 | 1320_1405 | 549.3333333333334 | 1492.0 | Compositional bias | Note=Arg-rich |
Hgene | ARHGAP23 | chr17:36623572 | chr17:34397807 | ENST00000437668 | + | 7 | 25 | 1320_1405 | 549.3333333333334 | 1145.0 | Compositional bias | Note=Arg-rich |
Hgene | ARHGAP23 | chr17:36623572 | chr17:34397807 | ENST00000431231 | + | 7 | 24 | 688_808 | 549.3333333333334 | 1492.0 | Domain | PH |
Hgene | ARHGAP23 | chr17:36623572 | chr17:34397807 | ENST00000431231 | + | 7 | 24 | 905_1097 | 549.3333333333334 | 1492.0 | Domain | Rho-GAP |
Hgene | ARHGAP23 | chr17:36623572 | chr17:34397807 | ENST00000437668 | + | 7 | 25 | 688_808 | 549.3333333333334 | 1145.0 | Domain | PH |
Hgene | ARHGAP23 | chr17:36623572 | chr17:34397807 | ENST00000437668 | + | 7 | 25 | 905_1097 | 549.3333333333334 | 1145.0 | Domain | Rho-GAP |
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Fusion Gene Sequence for ARHGAP23-CCL18 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000431231_ENST00000004921_TCGA-TQ-A7RP-01A_ARHGAP23_chr17_36623572_+_CCL18_chr17_34397807_length(transcript)=2910nt_BP=1716nt CCGCCCCTCCCGGGTCCCTGCCGGCGCCCCCAGCCGTGCCCCGGCCGCAGAGCCGCCGCTGCCACCCGATGAATGGAGTCGCCTTCTGCC TGGTCGGGATCCCGCCCCGCCCGGAGCCCCGGCCCCCACAGCTGCCACTGGGCCCAAGAGATGGGTGCTCTCCTAGGCGCCCCTTCCCCT GGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCTTTGGCTTCACTCTGCGCCACTTCATCGTGTACCCACCCGAGT CGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAGGAGGACCCTCCCCCCGGTACCGCCTGGAGCCCATGGACACCA TCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGCTTCGCACAGGAGACCGGCTGGTAAAGGTGAATGGGGAAAGCG TCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTGATGACACTCTGGAGCTGTCTATCATGCCCAAGGACGAGGACA TCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGCCGTATTCTGGAGAGGCCCGCAGCATCCCAGAGCCACCGCCGA TCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCAGGGCCACTATGGTGCCTGAGCCCACCTCAGCACTGCCCAGTG ACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCACCTGCTGCCCGTGCCCACCTGGACAACTCTTCCTTGGGGATGA GCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGCCCCGGACGCCCCGTGCCTTCCCAGAGCCTGGCAGCCGGGTGC CCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAAACCAGGTACCCCGCCGGGCGGGGGAGAGACGGTGCCCAGCCA TGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGGCTGCCCCCCGCCCGTGGCCCTGCTCCACCTCCCAGGATGCTT TGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACTACTTGAGCCGGGCCACCCGTTCTGCCGAGGCACTGGGGCCAG GGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGCGTTCGTCTGCCCGCACCCCCGCCTGCCCAACTCGGGACCTGC CAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACCTCGGGTACATCGGCTACCGGAGCTACAGCCCATCATTCCAGC GCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTGGGGGGCTGCCTACCTTCAACCTGGCCCAGTCCCCTGCGTCAT TCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCAGCACCCGGGCCCTGGAGCCTCCTGCGGAGGATCGCGGCGATG AGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGACCCCCGCAAGACAGATGAACCTTGGATTTGGTGACGAGTCCC CAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGGCCCCTTTGGCCACCACCGAAGACTCTCTGGCTTCCATCCCCT TTATTGTTGGTACCAACAAAGAGCTCTGCTGCCTCGTCTATACCTCCTGGCAGATTCCACAAAAGTTCATAGTTGACTATTCTGAAACCA GCCCCCAGTGCCCCAAGCCAGGTGTCATCCTCCTAACCAAGAGAGGCCGGCAGATCTGTGCTGACCCCAATAAGAAGTGGGTCCAGAAAT ACATCAGCGACCTGAAGCTGAATGCCTGAGGGGCCTGGAAGCTGCGAGGGCCCAGTGAACTTGGTGGGCCCAGGAGGGAACAGGAGCCTG AGCCAGGGCAATGGCCCTGCCACCCTGGAGGCCACCTCTTCTAAGAGTCCCATCTGCTATGCCCAGCCACATTAACTAACTTTAATCTTA GTTTATGCATCATATTTCATTTTGAAATTGATTTCTATTGTTGAGCTGCATTATGAAATTAGTATTTTCTCTGACATCTCATGACATTGT CTTTATCATCCTTTCCCCTTTCCCTTCAACTCTTCGTACATTCAATGCATGGATCAATCAGTGTGATTAGCTTTCTCAGCAGACATTGTG CCATATGTATCAAATGACAAATCTTTATTGAATGGTTTTGCTCAGCACCACCTTTTAATATATTGGCAGTACTTATTATATAAAAGGTAA ACCAGCATTCTCACTGTGACGACTCTGTTGATTTTGTTTCACTAATCGGAATCACAGACTGAGAGGAATTCTGGGGGAGGAGTAGGGAAA TATGAAAAGGGGCAGAAACAGCAAGATAGGGACCAAGTACTTCTACAGTCATACCAGACATTTCCCTGGAGATACTTTCCTGAAAAGTTG AAACAGACACCATTAGTTTATAAACCATATTGTAACTGAAATGTGATAGAAAAATTTTCTACTTAAATGAATATCAAGATGACGCTGCAA TGCATATTTACGCACACAAGCTCATTTTCATAAATGAAGCTTTCCTCAGAATGATGGCTAACATCTGTTGAGGTCTTACCAAGTGCTGGG TTTTGGGCTAAGTACTTATATTAGTAAAAGTCTAGCAAATACTGCCCATAGTCTAGCAAGGACTCCTTACCTGGAAGTTGCTGAAAGCCT TGGTAATGTTATCTTTGTTCTCCACTCTGCTTTTGGGGAGGATGTTTTCCATGACTATACGAGATGAGGCTTGGGGCTGGGTGGCCAGAG >In-frame_ENST00000431231_ENST00000004921_TCGA-TQ-A7RP-01A_ARHGAP23_chr17_36623572_+_CCL18_chr17_34397807_length(amino acids)=633AA_start in transcript=17_stop in transcript=1918 MPAPPAVPRPQSRRCHPMNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCS LKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAY SQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPS PGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQ EGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLL HALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEAS GRGERLGRKVAPLATTEDSLASIPFIVGTNKELCCLVYTSWQIPQKFIVDYSETSPQCPKPGVILLTKRGRQICADPNKKWVQKYISDLK -------------------------------------------------------------- >In-frame_ENST00000437668_ENST00000004921_TCGA-TQ-A7RP-01A_ARHGAP23_chr17_36623572_+_CCL18_chr17_34397807_length(transcript)=2842nt_BP=1648nt ATGAATGGAGTCGCCTTCTGCCTGGTCGGGATCCCGCCCCGCCCGGAGCCCCGGCCCCCACAGCTGCCACTGGGCCCAAGAGATGGGTGC TCTCCTAGGCGCCCCTTCCCCTGGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCTTTGGCTTCACTCTGCGCCAC TTCATCGTGTACCCACCCGAGTCGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAGGAGGACCCTCCCCCCGGTAC CGCCTGGAGCCCATGGACACCATCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGCTTCGCACAGGAGACCGGCTG GTAAAGGTGAATGGGGAAAGCGTCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTGATGACACTCTGGAGCTGTCT ATCATGCCCAAGGACGAGGACATCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGCCGTATTCTGGAGAGGCCCGC AGCATCCCAGAGCCACCGCCGATCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCAGGGCCACTATGGTGCCTGAG CCCACCTCAGCACTGCCCAGTGACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCACCTGCTGCCCGTGCCCACCTG GACAACTCTTCCTTGGGGATGAGCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGCCCCGGACGCCCCGTGCCTTC CCAGAGCCTGGCAGCCGGGTGCCCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAAACCAGGTACCCCGCCGGGCG GGGGAGAGACGGTGCCCAGCCATGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGGCTGCCCCCCGCCCGTGGCCC TGCTCCACCTCCCAGGATGCTTTGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACTACTTGAGCCGGGCCACCCGT TCTGCCGAGGCACTGGGGCCAGGGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGCGTTCGTCTGCCCGCACCCCC GCCTGCCCAACTCGGGACCTGCCAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACCTCGGGTACATCGGCTACCGG AGCTACAGCCCATCATTCCAGCGCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTGGGGGGCTGCCTACCTTCAAC CTGGCCCAGTCCCCTGCGTCATTCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCAGCACCCGGGCCCTGGAGCCT CCTGCGGAGGATCGCGGCGATGAGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGACCCCCGCAAGACAGATGAAC CTTGGATTTGGTGACGAGTCCCCAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGGCCCCTTTGGCCACCACCGAA GACTCTCTGGCTTCCATCCCCTTTATTGTTGGTACCAACAAAGAGCTCTGCTGCCTCGTCTATACCTCCTGGCAGATTCCACAAAAGTTC ATAGTTGACTATTCTGAAACCAGCCCCCAGTGCCCCAAGCCAGGTGTCATCCTCCTAACCAAGAGAGGCCGGCAGATCTGTGCTGACCCC AATAAGAAGTGGGTCCAGAAATACATCAGCGACCTGAAGCTGAATGCCTGAGGGGCCTGGAAGCTGCGAGGGCCCAGTGAACTTGGTGGG CCCAGGAGGGAACAGGAGCCTGAGCCAGGGCAATGGCCCTGCCACCCTGGAGGCCACCTCTTCTAAGAGTCCCATCTGCTATGCCCAGCC ACATTAACTAACTTTAATCTTAGTTTATGCATCATATTTCATTTTGAAATTGATTTCTATTGTTGAGCTGCATTATGAAATTAGTATTTT CTCTGACATCTCATGACATTGTCTTTATCATCCTTTCCCCTTTCCCTTCAACTCTTCGTACATTCAATGCATGGATCAATCAGTGTGATT AGCTTTCTCAGCAGACATTGTGCCATATGTATCAAATGACAAATCTTTATTGAATGGTTTTGCTCAGCACCACCTTTTAATATATTGGCA GTACTTATTATATAAAAGGTAAACCAGCATTCTCACTGTGACGACTCTGTTGATTTTGTTTCACTAATCGGAATCACAGACTGAGAGGAA TTCTGGGGGAGGAGTAGGGAAATATGAAAAGGGGCAGAAACAGCAAGATAGGGACCAAGTACTTCTACAGTCATACCAGACATTTCCCTG GAGATACTTTCCTGAAAAGTTGAAACAGACACCATTAGTTTATAAACCATATTGTAACTGAAATGTGATAGAAAAATTTTCTACTTAAAT GAATATCAAGATGACGCTGCAATGCATATTTACGCACACAAGCTCATTTTCATAAATGAAGCTTTCCTCAGAATGATGGCTAACATCTGT TGAGGTCTTACCAAGTGCTGGGTTTTGGGCTAAGTACTTATATTAGTAAAAGTCTAGCAAATACTGCCCATAGTCTAGCAAGGACTCCTT ACCTGGAAGTTGCTGAAAGCCTTGGTAATGTTATCTTTGTTCTCCACTCTGCTTTTGGGGAGGATGTTTTCCATGACTATACGAGATGAG >In-frame_ENST00000437668_ENST00000004921_TCGA-TQ-A7RP-01A_ARHGAP23_chr17_36623572_+_CCL18_chr17_34397807_length(amino acids)=616AA_start in transcript=0_stop in transcript=1850 MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRY RLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAF PEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFN LAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE -------------------------------------------------------------- >In-frame_ENST00000443378_ENST00000004921_TCGA-TQ-A7RP-01A_ARHGAP23_chr17_36623572_+_CCL18_chr17_34397807_length(transcript)=3222nt_BP=2028nt GAAGGATGCGTGTGTGCCGGTCTGCTGTGCATGTGTGTATCTGCATGTCTGTGATGCATGCGCATGCGTCTGTATGTGCATTGTGTGTGC AGGACTTTGATTCTGTGCAACTCTGTGCATATCTATGTGTCTACAAAAGTGTGCACATGTGTACTCATTTGTGTGTGTGTATCTGTGTGT CTGCATATTTGCACATGCTTGTCTGTATGTTTGTGGTATGTTCCGTCTACATGAGTGTATGTGGCTGGGGCTGTGTCTGCATAAGTATGT GTCTATCTGGGAGTGCATATATGTGTGCATGTGTGTGTGTGAGATTGTGCATGAGCTAAGACAACGACAGGCACTTCCTGGGCAGGAAGG CTGTATCCAGGGTCCTGCACATAGTAGGTGCTCAGTGAACATTTGCTGAACTCAGCTGAACTGAACTGAATGAACTTGCTTCACTGCCAC TGGGCCCAAGAGATGGGTGCTCTCCTAGGCGCCCCTTCCCCTGGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCT TTGGCTTCACTCTGCGCCACTTCATCGTGTACCCACCCGAGTCGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAG GAGGACCCTCCCCCCGGTACCGCCTGGAGCCCATGGACACCATCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGC TTCGCACAGGAGACCGGCTGGTAAAGGTGAATGGGGAAAGCGTCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTG ATGACACTCTGGAGCTGTCTATCATGCCCAAGGACGAGGACATCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGC CGTATTCTGGAGAGGCCCGCAGCATCCCAGAGCCACCGCCGATCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCA GGGCCACTATGGTGCCTGAGCCCACCTCAGCACTGCCCAGTGACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCAC CTGCTGCCCGTGCCCACCTGGACAACTCTTCCTTGGGGATGAGCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGC CCCGGACGCCCCGTGCCTTCCCAGAGCCTGGCAGCCGGGTGCCCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAA ACCAGGTACCCCGCCGGGCGGGGGAGAGACGGTGCCCAGCCATGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGG CTGCCCCCCGCCCGTGGCCCTGCTCCACCTCCCAGGATGCTTTGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACT ACTTGAGCCGGGCCACCCGTTCTGCCGAGGCACTGGGGCCAGGGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGC GTTCGTCTGCCCGCACCCCCGCCTGCCCAACTCGGGACCTGCCAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACC TCGGGTACATCGGCTACCGGAGCTACAGCCCATCATTCCAGCGCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTG GGGGGCTGCCTACCTTCAACCTGGCCCAGTCCCCTGCGTCATTCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCA GCACCCGGGCCCTGGAGCCTCCTGCGGAGGATCGCGGCGATGAGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGA CCCCCGCAAGACAGATGAACCTTGGATTTGGTGACGAGTCCCCAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGG CCCCTTTGGCCACCACCGAAGACTCTCTGGCTTCCATCCCCTTTATTGTTGGTACCAACAAAGAGCTCTGCTGCCTCGTCTATACCTCCT GGCAGATTCCACAAAAGTTCATAGTTGACTATTCTGAAACCAGCCCCCAGTGCCCCAAGCCAGGTGTCATCCTCCTAACCAAGAGAGGCC GGCAGATCTGTGCTGACCCCAATAAGAAGTGGGTCCAGAAATACATCAGCGACCTGAAGCTGAATGCCTGAGGGGCCTGGAAGCTGCGAG GGCCCAGTGAACTTGGTGGGCCCAGGAGGGAACAGGAGCCTGAGCCAGGGCAATGGCCCTGCCACCCTGGAGGCCACCTCTTCTAAGAGT CCCATCTGCTATGCCCAGCCACATTAACTAACTTTAATCTTAGTTTATGCATCATATTTCATTTTGAAATTGATTTCTATTGTTGAGCTG CATTATGAAATTAGTATTTTCTCTGACATCTCATGACATTGTCTTTATCATCCTTTCCCCTTTCCCTTCAACTCTTCGTACATTCAATGC ATGGATCAATCAGTGTGATTAGCTTTCTCAGCAGACATTGTGCCATATGTATCAAATGACAAATCTTTATTGAATGGTTTTGCTCAGCAC CACCTTTTAATATATTGGCAGTACTTATTATATAAAAGGTAAACCAGCATTCTCACTGTGACGACTCTGTTGATTTTGTTTCACTAATCG GAATCACAGACTGAGAGGAATTCTGGGGGAGGAGTAGGGAAATATGAAAAGGGGCAGAAACAGCAAGATAGGGACCAAGTACTTCTACAG TCATACCAGACATTTCCCTGGAGATACTTTCCTGAAAAGTTGAAACAGACACCATTAGTTTATAAACCATATTGTAACTGAAATGTGATA GAAAAATTTTCTACTTAAATGAATATCAAGATGACGCTGCAATGCATATTTACGCACACAAGCTCATTTTCATAAATGAAGCTTTCCTCA GAATGATGGCTAACATCTGTTGAGGTCTTACCAAGTGCTGGGTTTTGGGCTAAGTACTTATATTAGTAAAAGTCTAGCAAATACTGCCCA TAGTCTAGCAAGGACTCCTTACCTGGAAGTTGCTGAAAGCCTTGGTAATGTTATCTTTGTTCTCCACTCTGCTTTTGGGGAGGATGTTTT >In-frame_ENST00000443378_ENST00000004921_TCGA-TQ-A7RP-01A_ARHGAP23_chr17_36623572_+_CCL18_chr17_34397807_length(amino acids)=601AA_start in transcript=425_stop in transcript=2230 MNELASLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKE DGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTY APPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQ QALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRF ERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEP PRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIVGTNKE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ARHGAP23-CCL18 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARHGAP23-CCL18 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARHGAP23-CCL18 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ARHGAP23 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Hgene | ARHGAP23 | C1136382 | Sclerocystic Ovaries | 1 | CTD_human |
Tgene | CCL18 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Tgene | CCL18 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | CCL18 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |