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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OGT-DMXL1 (FusionGDB2 ID:61038)

Fusion Gene Summary for OGT-DMXL1

check button Fusion gene summary
Fusion gene informationFusion gene name: OGT-DMXL1
Fusion gene ID: 61038
HgeneTgene
Gene symbol

OGT

DMXL1

Gene ID

8473

1657

Gene nameO-linked N-acetylglucosamine (GlcNAc) transferaseDmx like 1
SynonymsHINCUT-1|HRNT1|MRX106|O-GLCNAC|OGT1-
Cytomap

Xq13.1

5q23.1

Type of geneprotein-codingprotein-coding
DescriptionUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitO-GlcNAc transferase p110 subunitO-GlcNAc transferase subunit p110O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminydmX-like protein 1
Modification date2020032720200313
UniProtAcc.

Q9Y485

Ensembl transtripts involved in fusion geneENST00000373719, ENST00000373701, 
ENST00000498566, 		ENST00000311085, 
ENST00000539542, ENST00000505312, 
Fusion gene scores* DoF score9 X 9 X 4=3244 X 5 X 4=80
# samples 105
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OGT [Title/Abstract] AND DMXL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOGT(70784603)-DMXL1(118582689), # samples:1
Anticipated loss of major functional domain due to fusion event.OGT-DMXL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
OGT-DMXL1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
OGT-DMXL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOGT

GO:0006110

regulation of glycolytic process

22923583

HgeneOGT

GO:0006493

protein O-linked glycosylation

21240259|21285374|22923583|23222540|23352454|24474760

HgeneOGT

GO:0006915

apoptotic process

20824293

HgeneOGT

GO:0032868

response to insulin

18288188

HgeneOGT

GO:0035020

regulation of Rac protein signal transduction

18288188

HgeneOGT

GO:0043981

histone H4-K5 acetylation

20018852

HgeneOGT

GO:0043982

histone H4-K8 acetylation

20018852

HgeneOGT

GO:0043984

histone H4-K16 acetylation

20018852

HgeneOGT

GO:0045862

positive regulation of proteolysis

21285374

HgeneOGT

GO:0045944

positive regulation of transcription by RNA polymerase II

23222540|23353889

HgeneOGT

GO:0046626

regulation of insulin receptor signaling pathway

18288188

HgeneOGT

GO:0048015

phosphatidylinositol-mediated signaling

18288188


check buttonFusion gene breakpoints across OGT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DMXL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer173NOGTchrX

70784603

+DMXL1chr5

118582689

+


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Fusion Gene ORF analysis for OGT-DMXL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373719ENST00000311085OGTchrX

70784603

+DMXL1chr5

118582689

+
Frame-shiftENST00000373719ENST00000539542OGTchrX

70784603

+DMXL1chr5

118582689

+
5CDS-3UTRENST00000373719ENST00000505312OGTchrX

70784603

+DMXL1chr5

118582689

+
In-frameENST00000373701ENST00000311085OGTchrX

70784603

+DMXL1chr5

118582689

+
Frame-shiftENST00000373701ENST00000539542OGTchrX

70784603

+DMXL1chr5

118582689

+
5CDS-3UTRENST00000373701ENST00000505312OGTchrX

70784603

+DMXL1chr5

118582689

+
intron-3CDSENST00000498566ENST00000311085OGTchrX

70784603

+DMXL1chr5

118582689

+
intron-3CDSENST00000498566ENST00000539542OGTchrX

70784603

+DMXL1chr5

118582689

+
intron-3UTRENST00000498566ENST00000505312OGTchrX

70784603

+DMXL1chr5

118582689

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373719OGTchrX70784603+ENST00000311085DMXL1chr5118582689+49392806673030987
ENST00000373701OGTchrX70784603+ENST00000311085DMXL1chr5118582689+48692736272960977

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373719ENST00000311085OGTchrX70784603+DMXL1chr5118582689+0.0003188810.9996811
ENST00000373701ENST00000311085OGTchrX70784603+DMXL1chr5118582689+0.0003647930.9996352

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Fusion Genomic Features for OGT-DMXL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
OGTchrX70784603+DMXL1chr5118582689+0.98964880.010351134
OGTchrX70784603+DMXL1chr5118582689+0.98964880.010351134

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for OGT-DMXL1


check button Go to

FGviewer for the breakpoints of chrX:70784603-chr5:118582689

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DMXL1

Q9Y485

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922487_503853.01037.0MotifNuclear localization signal
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922487_503863.01047.0MotifNuclear localization signal
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922123_156853.01037.0RepeatNote=TPR 3
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922157_190853.01037.0RepeatNote=TPR 4
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922191_224853.01037.0RepeatNote=TPR 5
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+192221_54853.01037.0RepeatNote=TPR 1
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922225_258853.01037.0RepeatNote=TPR 6
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922259_292853.01037.0RepeatNote=TPR 7
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922293_326853.01037.0RepeatNote=TPR 8
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922327_360853.01037.0RepeatNote=TPR 9
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922361_394853.01037.0RepeatNote=TPR 10
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922395_428853.01037.0RepeatNote=TPR 11
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922429_462853.01037.0RepeatNote=TPR 12
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922463_473853.01037.0RepeatNote=TPR 13%3B truncated
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+192289_122853.01037.0RepeatNote=TPR 2
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922123_156863.01047.0RepeatNote=TPR 3
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922157_190863.01047.0RepeatNote=TPR 4
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922191_224863.01047.0RepeatNote=TPR 5
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+192221_54863.01047.0RepeatNote=TPR 1
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922225_258863.01047.0RepeatNote=TPR 6
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922259_292863.01047.0RepeatNote=TPR 7
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922293_326863.01047.0RepeatNote=TPR 8
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922327_360863.01047.0RepeatNote=TPR 9
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922361_394863.01047.0RepeatNote=TPR 10
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922395_428863.01047.0RepeatNote=TPR 11
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922429_462863.01047.0RepeatNote=TPR 12
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922463_473863.01047.0RepeatNote=TPR 13%3B truncated
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+192289_122863.01047.0RepeatNote=TPR 2
TgeneDMXL1chrX:70784603chr5:118582689ENST0000031108541432978_30162953.03028.0RepeatNote=WD 16

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922906_908853.01037.0Nucleotide bindingUDP
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922911_914853.01037.0Nucleotide bindingUDP
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922930_932853.01037.0Nucleotide bindingUDP
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922906_908863.01047.0Nucleotide bindingUDP
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922911_914863.01047.0Nucleotide bindingUDP
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922930_932863.01047.0Nucleotide bindingUDP
HgeneOGTchrX:70784603chr5:118582689ENST00000373701+1922991_1010853.01037.0RegionNote=Required for phosphatidylinositol 3%2C4%2C5-triphosphate binding
HgeneOGTchrX:70784603chr5:118582689ENST00000373719+1922991_1010863.01047.0RegionNote=Required for phosphatidylinositol 3%2C4%2C5-triphosphate binding
TgeneDMXL1chrX:70784603chr5:118582689ENST0000031108541432459_24682953.03028.0Compositional biasNote=Poly-Asp
TgeneDMXL1chrX:70784603chr5:118582689ENST000003110854143108_1452953.03028.0RepeatNote=WD 1
TgeneDMXL1chrX:70784603chr5:118582689ENST0000031108541431134_11752953.03028.0RepeatNote=WD 9
TgeneDMXL1chrX:70784603chr5:118582689ENST0000031108541431211_12512953.03028.0RepeatNote=WD 10
TgeneDMXL1chrX:70784603chr5:118582689ENST000003110854143166_2062953.03028.0RepeatNote=WD 2
TgeneDMXL1chrX:70784603chr5:118582689ENST000003110854143229_2772953.03028.0RepeatNote=WD 3
TgeneDMXL1chrX:70784603chr5:118582689ENST0000031108541432742_27832953.03028.0RepeatNote=WD 11
TgeneDMXL1chrX:70784603chr5:118582689ENST0000031108541432785_28242953.03028.0RepeatNote=WD 12
TgeneDMXL1chrX:70784603chr5:118582689ENST0000031108541432836_28782953.03028.0RepeatNote=WD 12
TgeneDMXL1chrX:70784603chr5:118582689ENST0000031108541432884_29232953.03028.0RepeatNote=WD 14
TgeneDMXL1chrX:70784603chr5:118582689ENST0000031108541432926_29652953.03028.0RepeatNote=WD 15
TgeneDMXL1chrX:70784603chr5:118582689ENST000003110854143476_5162953.03028.0RepeatNote=WD 4
TgeneDMXL1chrX:70784603chr5:118582689ENST000003110854143580_6212953.03028.0RepeatNote=WD 5
TgeneDMXL1chrX:70784603chr5:118582689ENST000003110854143628_6652953.03028.0RepeatNote=WD 6
TgeneDMXL1chrX:70784603chr5:118582689ENST000003110854143848_8952953.03028.0RepeatNote=WD 7
TgeneDMXL1chrX:70784603chr5:118582689ENST000003110854143968_10102953.03028.0RepeatNote=WD 8


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Fusion Gene Sequence for OGT-DMXL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000373719_ENST00000311085_173N_OGT_chrX_70784603_+_DMXL1_chr5_118582689_length(transcript)=4939nt_BP=2806nt
GGCCGAGGAGCCGTCGCCGCCATTTCAAGACCGTACTAGGTAGATGGTCAATTAGAGTTCCCAGGGTTTGAAGCCTGTAACTGCTGCCGC
CGCTCAAGCCCTCCAGAGCATTGCTACGGCTGCTGCCCTTGTACTACTACCTCCAAATACGTTCTTGCTGGTAGTGGCGGCAGCAGGACC
AATTACCTCTTTTTTGCTCTCCCTCGAGAAGCTCCAGATGGCGTCTTCCGTGGGCAACGTGGCCGACAGCACAGAACCAACGAAACGTAT
GCTTTCCTTCCAAGGGTTAGCTGAGTTGGCACATCGAGAATATCAGGCAGGAGATTTTGAGGCAGCTGAGAGACACTGCATGCAGCTCTG
GAGACAAGAGCCAGACAATACTGGTGTGCTTTTATTACTTTCATCTATACACTTCCAGTGTCGAAGGCTGGACAGATCTGCTCACTTTAG
CACTCTGGCAATTAAACAGAACCCCCTTCTGGCAGAAGCTTATTCGAATTTGGGGAATGTGTACAAGGAAAGAGGGCAGTTGCAGGAGGC
AATTGAGCATTATCGACATGCATTGCGTCTCAAACCTGATTTCATCGATGGTTATATTAACCTGGCAGCCGCCTTGGTAGCAGCGGGTGA
CATGGAAGGGGCAGTACAAGCTTACGTCTCTGCTCTTCAGTACAATCCTGATTTGTACTGTGTTCGCAGTGACCTGGGGAACCTGCTCAA
AGCCCTGGGTCGCTTGGAAGAAGCCAAGGCATGTTATTTGAAAGCAATTGAGACGCAACCGAACTTTGCAGTAGCTTGGAGTAATCTTGG
CTGTGTTTTCAATGCACAAGGGGAAATTTGGCTTGCAATTCATCACTTTGAAAAGGCTGTCACCCTTGACCCAAACTTTCTGGATGCTTA
TATCAATTTAGGAAATGTCTTGAAAGAGGCACGCATTTTTGACAGAGCTGTGGCAGCTTATCTTCGTGCCCTAAGTTTGAGTCCAAATCA
CGCAGTGGTGCACGGCAACCTGGCTTGTGTATACTATGAGCAAGGCCTGATAGATCTGGCAATAGACACCTACAGGCGGGCTATCGAACT
ACAACCACATTTCCCTGATGCTTACTGCAACCTAGCCAATGCTCTCAAAGAGAAGGGCAGTGTTGCTGAAGCAGAAGATTGTTATAATAC
AGCTCTCCGTCTGTGTCCCACCCATGCAGACTCTCTGAATAACCTAGCCAATATCAAACGAGAACAGGGAAACATTGAAGAGGCAGTTCG
CTTGTATCGTAAAGCATTAGAAGTCTTCCCAGAGTTTGCTGCTGCCCATTCAAATTTAGCAAGTGTACTGCAGCAGCAGGGAAAACTGCA
GGAAGCTCTGATGCATTATAAGGAGGCTATTCGAATCAGTCCTACCTTTGCTGATGCCTACTCTAATATGGGAAACACTCTAAAGGAGAT
GCAGGATGTTCAGGGAGCCTTGCAGTGTTATACGCGTGCCATCCAAATTAATCCTGCATTTGCAGATGCACATAGCAATCTGGCTTCCAT
TCATAAGGATTCAGGGAATATTCCAGAAGCCATAGCTTCTTACCGCACGGCTCTGAAACTTAAGCCTGATTTTCCTGATGCTTATTGTAA
CTTGGCTCATTGCCTGCAGATTGTCTGTGATTGGACAGACTATGATGAGCGAATGAAGAAGTTGGTCAGTATTGTGGCTGACCAGTTAGA
GAAGAATAGGTTGCCTTCTGTGCATCCTCATCATAGTATGCTATATCCTCTTTCTCATGGCTTCAGGAAGGCTATTGCTGAGAGGCACGG
CAACCTGTGCTTAGATAAGATTAATGTTCTTCATAAACCACCATATGAACATCCAAAAGACTTGAAGCTCAGTGATGGTCGGCTGCGTGT
AGGATATGTGAGTTCCGACTTTGGGAATCATCCTACTTCTCACCTTATGCAGTCTATTCCAGGCATGCACAATCCTGATAAATTTGAGGT
GTTCTGTTATGCCCTGAGCCCAGACGATGGCACAAACTTCCGAGTGAAGGTGATGGCAGAAGCCAATCATTTCATTGATCTTTCTCAGAT
TCCATGCAATGGAAAAGCAGCTGATCGCATCCATCAGGATGGAATTCATATCCTTGTAAATATGAATGGCTATACTAAGGGCGCTCGAAA
TGAGCTTTTTGCTCTCAGGCCAGCTCCTATTCAGGCAATGTGGCTGGGATACCCTGGGACGAGTGGTGCGCTTTTCATGGATTATATTAT
CACTGATCAGGAAACTTCGCCAGCTGAAGTTGCTGAGCAGTATTCCGAGAAATTGGCTTATATGCCCCACACTTTTTTTATTGGTGATCA
TGCTAATATGTTCCCTCACCTGAAGAAAAAAGCAGTCATCGATTTTAAGTCCAATGGGCACATTTATGACAATCGGATAGTTCTGAATGG
CATCGACCTCAAAGCATTTCTTGATAGTCTACCAGATGTGAAAATTGTCAAGATGAAGTGTCCTGATGGAGGAGACAATGCAGATAGCAG
TAACACAGCTCTTAATATGCCTGTTATTCCTATGAATACTATTGCAGAAGCAGTTATTGAAATGATTAACCGAGGACAGATTCAAATAAC
AATTAATGGATTCAGTATTAGCAATGGACTGGCAACTACTCAGATCAACAATAAGGCTGCAACTGGAGAGGAGGTTCCCCGTACCATTAT
TGTAACCACCCGTTCTCAGTACGGGTTACCAGAAGATGCCATCGTATACTGTAACTTTAATCAGTTGTATAAAATTGACCCTTCTACTTT
GCAGATGTGGGCAAACATTTGGAGTCTCTCTACCTTTGGTCTTCTCCATACTTTTGTCAGTGAACATGCTCGGCAGTCCATTTTTAGAAA
TATTGGAACTGGAGTGATGCAAATTGAGACAGGGCCTGCAAATCACATTTTCTCCTGTGGAGCTGATGGAACAATGAAAATGAGAATACT
GCCAGATCAGTTTAGCCCTTTAAATGAAGTGTTGAAAAATGATGTGAAATTTATGCTATAACATTTTTACAATAAGATGTACAATTTATT
ACCTATATGGAAGTGGCCAACAGATATAATATACAGTGATCATTCTCTATGCCACAAATTAGCTAATGCTTTCTTGTTTTTATATTTATT
TTATGGAGCTTTGCCCTTGATGCACTGATGCCTTAAAAATTAACAAGGTCATTCAGAAGTAGATTACATTGCCTAAAGTAGAATGTGTAA
GTAATGCTGTAATAATACATATCATAGTATATTATAATCAGTATGTCATAGTGTTAAAGGTGTTTTGTTTTCTTATTGATACTTTTCCAC
AGGCATCTCTGCATGAATTTCTTCCACAGTAAAAATACGTTTTTTGTAAAGGCAATTGTACATAATACTCATCACTTAATTCACCACACT
CTCACTTCCTTTATTAGCCTTATACATCTCAAACTCTTCTCTTAATTAATGATAGGTATTTGAGTAAGAATGAAAAAAATAATGAACATC
TTCATTAAAATTGTCATTGAGACGTCAGTGATAAATGAGCTAGATGGCTCAATATGTAAGGTTTTCAGTAGTTTACCCTCCGGAACCCAA
GTTGTATGTATGTATACGTGTGTGTGTGTGTGTGTGTGTGTATCTTACACATCTTATTTGAACTTAGTTGTATATATTAGCGAAAACTGG
TTTTTCATGTGTTTTTGTGCCATAACAACTATTGCCACCAGAATAACTTTTTTTTTGCAACTGTGCTTTTCATTTTTAAAAAATTTTTGA
ATTCCCATCCTAATTTTCAAATAAGTTTCAAGGAGACTATCAGGATTATTATTTTAAAGATTAGATTTAGTCAAATAAGTCTTAGCAGGC
AATAAAGTTTCTGTGGTGGCATATATCATGTAAGACACTTAAAGTAAGTTTGTGAATTTGTCAACTTTCGAGCATCAAACAAATATTTTA
CTTAAATTTTATTTTATCTTATTTTTAGGTGCTTTTAATCTCAAAATTCTGAAAAGCGAATAGCAGTGTTTTCAGAAACAAATGTGAAAG
CAGTCAAATTAAGTAGATACTATTTAGAAATGTAAAATACTCTCCAGATCTACCATTAATAGAAAATAAACTAAACCTTATATTTTATTT
TTGCCAAAATATTTTATTATAAAATATGACCAAAATATTTAAAATGCACAATGCTTTTAACTTAAATGTGCTAACCCTGTTTCTGTCTGT
TTTGTGCTGTACCTTTTCTGATTCAGAATTATAGAAAACTTGATAAATACTTGATTTTAACCAATGAGACTACAGGCAGATGGGACTAAG
TGTTTATGGGACAATTATGTACTATTTAACTTAAATATATTTTGTTTAATAGGAAATATATAATAATAGCATTTTATGTAATAAAATATG
GGCAACGATTATCTTGGAAATTAAAGAGTCAAAGCAAAGAAATGAAGGGCTGGTAAAATGAATTTTGTAATATCCTCAGGATACTTTTAT
CTTAAAAGTATGTTGTTAAAGATTTTGTAAATTGTATTTCAACAATTTTAAATGTGTTGAGCAAGTTGCAGTGCAAACACTGTCATTATG
TAGAGAGTTTATATGCACATAATAACCTGTACCTATAAATCGTGCAATAACCATATGCGACTATTTTGCCATGGAGAAATCTGACAGCAT
TGCAAACAATAGTATTGTTTGATGTAGTTAACCTTAAGTTATTTTTCAGTAATTTCTTCACAAATCAAGATTCAAACAGCTTTAAACACT
TCCAATGAGATAAAATATTTACTATTATGCTTATTAGAACAAAAGGTGTTTAAGGATGAACTAAATATTTTAATTGAGCATTTATATGGA

>In-frame_ENST00000373719_ENST00000311085_173N_OGT_chrX_70784603_+_DMXL1_chr5_118582689_length(amino acids)=987AA_start in transcript=67_stop in transcript=3030
MKPVTAAAAQALQSIATAAALVLLPPNTFLLVVAAAGPITSFLLSLEKLQMASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAA
ERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA
AALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTL
DPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVA
EAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSN
MGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLV
SIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGM
HNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSG
ALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPD
GGDNADSSNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQL

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>In-frame_ENST00000373701_ENST00000311085_173N_OGT_chrX_70784603_+_DMXL1_chr5_118582689_length(transcript)=4869nt_BP=2736nt
TAGATGGTCAATTAGAGTTCCCAGGGTTTGAAGCCTGTAACTGCTGCCGCCGCTCAAGCCCTCCAGAGCATTGCTACGGCTGCTGCCCTT
GTACTACTACCTCCAAATACGTTCTTGCTGGTAGTGGCGGCAGCAGGACCAATTACCTCTTTTTTGCTCTCCCTCGAGAAGCTCCAGATG
GCGTCTTCCGTGGGCAACGTGGCCGACAGCACAGGGTTAGCTGAGTTGGCACATCGAGAATATCAGGCAGGAGATTTTGAGGCAGCTGAG
AGACACTGCATGCAGCTCTGGAGACAAGAGCCAGACAATACTGGTGTGCTTTTATTACTTTCATCTATACACTTCCAGTGTCGAAGGCTG
GACAGATCTGCTCACTTTAGCACTCTGGCAATTAAACAGAACCCCCTTCTGGCAGAAGCTTATTCGAATTTGGGGAATGTGTACAAGGAA
AGAGGGCAGTTGCAGGAGGCAATTGAGCATTATCGACATGCATTGCGTCTCAAACCTGATTTCATCGATGGTTATATTAACCTGGCAGCC
GCCTTGGTAGCAGCGGGTGACATGGAAGGGGCAGTACAAGCTTACGTCTCTGCTCTTCAGTACAATCCTGATTTGTACTGTGTTCGCAGT
GACCTGGGGAACCTGCTCAAAGCCCTGGGTCGCTTGGAAGAAGCCAAGGCATGTTATTTGAAAGCAATTGAGACGCAACCGAACTTTGCA
GTAGCTTGGAGTAATCTTGGCTGTGTTTTCAATGCACAAGGGGAAATTTGGCTTGCAATTCATCACTTTGAAAAGGCTGTCACCCTTGAC
CCAAACTTTCTGGATGCTTATATCAATTTAGGAAATGTCTTGAAAGAGGCACGCATTTTTGACAGAGCTGTGGCAGCTTATCTTCGTGCC
CTAAGTTTGAGTCCAAATCACGCAGTGGTGCACGGCAACCTGGCTTGTGTATACTATGAGCAAGGCCTGATAGATCTGGCAATAGACACC
TACAGGCGGGCTATCGAACTACAACCACATTTCCCTGATGCTTACTGCAACCTAGCCAATGCTCTCAAAGAGAAGGGCAGTGTTGCTGAA
GCAGAAGATTGTTATAATACAGCTCTCCGTCTGTGTCCCACCCATGCAGACTCTCTGAATAACCTAGCCAATATCAAACGAGAACAGGGA
AACATTGAAGAGGCAGTTCGCTTGTATCGTAAAGCATTAGAAGTCTTCCCAGAGTTTGCTGCTGCCCATTCAAATTTAGCAAGTGTACTG
CAGCAGCAGGGAAAACTGCAGGAAGCTCTGATGCATTATAAGGAGGCTATTCGAATCAGTCCTACCTTTGCTGATGCCTACTCTAATATG
GGAAACACTCTAAAGGAGATGCAGGATGTTCAGGGAGCCTTGCAGTGTTATACGCGTGCCATCCAAATTAATCCTGCATTTGCAGATGCA
CATAGCAATCTGGCTTCCATTCATAAGGATTCAGGGAATATTCCAGAAGCCATAGCTTCTTACCGCACGGCTCTGAAACTTAAGCCTGAT
TTTCCTGATGCTTATTGTAACTTGGCTCATTGCCTGCAGATTGTCTGTGATTGGACAGACTATGATGAGCGAATGAAGAAGTTGGTCAGT
ATTGTGGCTGACCAGTTAGAGAAGAATAGGTTGCCTTCTGTGCATCCTCATCATAGTATGCTATATCCTCTTTCTCATGGCTTCAGGAAG
GCTATTGCTGAGAGGCACGGCAACCTGTGCTTAGATAAGATTAATGTTCTTCATAAACCACCATATGAACATCCAAAAGACTTGAAGCTC
AGTGATGGTCGGCTGCGTGTAGGATATGTGAGTTCCGACTTTGGGAATCATCCTACTTCTCACCTTATGCAGTCTATTCCAGGCATGCAC
AATCCTGATAAATTTGAGGTGTTCTGTTATGCCCTGAGCCCAGACGATGGCACAAACTTCCGAGTGAAGGTGATGGCAGAAGCCAATCAT
TTCATTGATCTTTCTCAGATTCCATGCAATGGAAAAGCAGCTGATCGCATCCATCAGGATGGAATTCATATCCTTGTAAATATGAATGGC
TATACTAAGGGCGCTCGAAATGAGCTTTTTGCTCTCAGGCCAGCTCCTATTCAGGCAATGTGGCTGGGATACCCTGGGACGAGTGGTGCG
CTTTTCATGGATTATATTATCACTGATCAGGAAACTTCGCCAGCTGAAGTTGCTGAGCAGTATTCCGAGAAATTGGCTTATATGCCCCAC
ACTTTTTTTATTGGTGATCATGCTAATATGTTCCCTCACCTGAAGAAAAAAGCAGTCATCGATTTTAAGTCCAATGGGCACATTTATGAC
AATCGGATAGTTCTGAATGGCATCGACCTCAAAGCATTTCTTGATAGTCTACCAGATGTGAAAATTGTCAAGATGAAGTGTCCTGATGGA
GGAGACAATGCAGATAGCAGTAACACAGCTCTTAATATGCCTGTTATTCCTATGAATACTATTGCAGAAGCAGTTATTGAAATGATTAAC
CGAGGACAGATTCAAATAACAATTAATGGATTCAGTATTAGCAATGGACTGGCAACTACTCAGATCAACAATAAGGCTGCAACTGGAGAG
GAGGTTCCCCGTACCATTATTGTAACCACCCGTTCTCAGTACGGGTTACCAGAAGATGCCATCGTATACTGTAACTTTAATCAGTTGTAT
AAAATTGACCCTTCTACTTTGCAGATGTGGGCAAACATTTGGAGTCTCTCTACCTTTGGTCTTCTCCATACTTTTGTCAGTGAACATGCT
CGGCAGTCCATTTTTAGAAATATTGGAACTGGAGTGATGCAAATTGAGACAGGGCCTGCAAATCACATTTTCTCCTGTGGAGCTGATGGA
ACAATGAAAATGAGAATACTGCCAGATCAGTTTAGCCCTTTAAATGAAGTGTTGAAAAATGATGTGAAATTTATGCTATAACATTTTTAC
AATAAGATGTACAATTTATTACCTATATGGAAGTGGCCAACAGATATAATATACAGTGATCATTCTCTATGCCACAAATTAGCTAATGCT
TTCTTGTTTTTATATTTATTTTATGGAGCTTTGCCCTTGATGCACTGATGCCTTAAAAATTAACAAGGTCATTCAGAAGTAGATTACATT
GCCTAAAGTAGAATGTGTAAGTAATGCTGTAATAATACATATCATAGTATATTATAATCAGTATGTCATAGTGTTAAAGGTGTTTTGTTT
TCTTATTGATACTTTTCCACAGGCATCTCTGCATGAATTTCTTCCACAGTAAAAATACGTTTTTTGTAAAGGCAATTGTACATAATACTC
ATCACTTAATTCACCACACTCTCACTTCCTTTATTAGCCTTATACATCTCAAACTCTTCTCTTAATTAATGATAGGTATTTGAGTAAGAA
TGAAAAAAATAATGAACATCTTCATTAAAATTGTCATTGAGACGTCAGTGATAAATGAGCTAGATGGCTCAATATGTAAGGTTTTCAGTA
GTTTACCCTCCGGAACCCAAGTTGTATGTATGTATACGTGTGTGTGTGTGTGTGTGTGTGTATCTTACACATCTTATTTGAACTTAGTTG
TATATATTAGCGAAAACTGGTTTTTCATGTGTTTTTGTGCCATAACAACTATTGCCACCAGAATAACTTTTTTTTTGCAACTGTGCTTTT
CATTTTTAAAAAATTTTTGAATTCCCATCCTAATTTTCAAATAAGTTTCAAGGAGACTATCAGGATTATTATTTTAAAGATTAGATTTAG
TCAAATAAGTCTTAGCAGGCAATAAAGTTTCTGTGGTGGCATATATCATGTAAGACACTTAAAGTAAGTTTGTGAATTTGTCAACTTTCG
AGCATCAAACAAATATTTTACTTAAATTTTATTTTATCTTATTTTTAGGTGCTTTTAATCTCAAAATTCTGAAAAGCGAATAGCAGTGTT
TTCAGAAACAAATGTGAAAGCAGTCAAATTAAGTAGATACTATTTAGAAATGTAAAATACTCTCCAGATCTACCATTAATAGAAAATAAA
CTAAACCTTATATTTTATTTTTGCCAAAATATTTTATTATAAAATATGACCAAAATATTTAAAATGCACAATGCTTTTAACTTAAATGTG
CTAACCCTGTTTCTGTCTGTTTTGTGCTGTACCTTTTCTGATTCAGAATTATAGAAAACTTGATAAATACTTGATTTTAACCAATGAGAC
TACAGGCAGATGGGACTAAGTGTTTATGGGACAATTATGTACTATTTAACTTAAATATATTTTGTTTAATAGGAAATATATAATAATAGC
ATTTTATGTAATAAAATATGGGCAACGATTATCTTGGAAATTAAAGAGTCAAAGCAAAGAAATGAAGGGCTGGTAAAATGAATTTTGTAA
TATCCTCAGGATACTTTTATCTTAAAAGTATGTTGTTAAAGATTTTGTAAATTGTATTTCAACAATTTTAAATGTGTTGAGCAAGTTGCA
GTGCAAACACTGTCATTATGTAGAGAGTTTATATGCACATAATAACCTGTACCTATAAATCGTGCAATAACCATATGCGACTATTTTGCC
ATGGAGAAATCTGACAGCATTGCAAACAATAGTATTGTTTGATGTAGTTAACCTTAAGTTATTTTTCAGTAATTTCTTCACAAATCAAGA
TTCAAACAGCTTTAAACACTTCCAATGAGATAAAATATTTACTATTATGCTTATTAGAACAAAAGGTGTTTAAGGATGAACTAAATATTT
TAATTGAGCATTTATATGGATAATCATACATTATGTAAGCCCATATGTATTTACATCCAGAGTCATAATATTTTAAATAAACAATCATGC

>In-frame_ENST00000373701_ENST00000311085_173N_OGT_chrX_70784603_+_DMXL1_chr5_118582689_length(amino acids)=977AA_start in transcript=27_stop in transcript=2960
MKPVTAAAAQALQSIATAAALVLLPPNTFLLVVAAAGPITSFLLSLEKLQMASSVGNVADSTGLAELAHREYQAGDFEAAERHCMQLWRQ
EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME
GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN
LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTAL
RLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD
VQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKN
RLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFC
YALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITD
QETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNT
ALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQM

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Fusion Gene PPI Analysis for OGT-DMXL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OGT-DMXL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OGT-DMXL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOGTC4478379MENTAL RETARDATION, X-LINKED 1063GENOMICS_ENGLAND;UNIPROT
TgeneDMXL1C0017638Glioma1CTD_human
TgeneDMXL1C0259783mixed gliomas1CTD_human
TgeneDMXL1C0555198Malignant Glioma1CTD_human