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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP23-RPL23 (FusionGDB2 ID:6110)

Fusion Gene Summary for ARHGAP23-RPL23

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP23-RPL23
Fusion gene ID: 6110
HgeneTgene
Gene symbol

ARHGAP23

RPL23

Gene ID

57636

9349

Gene nameRho GTPase activating protein 23ribosomal protein L23
Synonyms-L23|rpL17
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 23rho-type GTPase-activating protein 2360S ribosomal protein L2360S ribosomal protein L17large ribosomal subunit protein uL14ribosomal protein L17
Modification date2020031320200313
UniProtAcc

Q9P227

.
Ensembl transtripts involved in fusion geneENST00000431231, ENST00000437668, 
ENST00000582409, ENST00000443378, 
ENST00000394332, ENST00000394333, 
ENST00000479035, ENST00000245857, 
ENST00000577407, 
Fusion gene scores* DoF score13 X 12 X 10=156024 X 19 X 8=3648
# samples 1425
** MAII scorelog2(14/1560*10)=-3.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3648*10)=-3.86710572950266
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP23 [Title/Abstract] AND RPL23 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP23(36638919)-RPL23(37009358), # samples:3
Anticipated loss of major functional domain due to fusion event.ARHGAP23-RPL23 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ARHGAP23-RPL23 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPL23

GO:0032986

protein-DNA complex disassembly

19160485

TgeneRPL23

GO:1904667

negative regulation of ubiquitin protein ligase activity

15314173

TgeneRPL23

GO:2000059

negative regulation of ubiquitin-dependent protein catabolic process

15314173


check buttonFusion gene breakpoints across ARHGAP23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RPL23 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5KX-01AARHGAP23chr17

36638919

+RPL23chr17

37009358

-
ChimerDB4ACCTCGA-OR-A5KXARHGAP23chr17

36638919

+RPL23chr17

37009358

-
ChimerDB4ACCTCGA-OR-A5KX-01AARHGAP23chr17

36638919

+RPL23chr17

37009358

-
ChiTaRS5.0N/AEC574239ARHGAP23chr17

36662177

-RPL23chr17

37009992

-


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Fusion Gene ORF analysis for ARHGAP23-RPL23

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000431231ENST00000394332ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
Frame-shiftENST00000431231ENST00000394333ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
Frame-shiftENST00000431231ENST00000479035ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
5CDS-5UTRENST00000431231ENST00000245857ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
5CDS-5UTRENST00000431231ENST00000577407ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
In-frameENST00000437668ENST00000394332ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
Frame-shiftENST00000437668ENST00000394333ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
Frame-shiftENST00000437668ENST00000479035ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
5CDS-5UTRENST00000437668ENST00000245857ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
5CDS-5UTRENST00000437668ENST00000577407ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
intron-3CDSENST00000582409ENST00000394332ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
intron-3CDSENST00000582409ENST00000394333ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
intron-3CDSENST00000582409ENST00000479035ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
intron-5UTRENST00000582409ENST00000245857ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
intron-5UTRENST00000582409ENST00000577407ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
In-frameENST00000443378ENST00000394332ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
Frame-shiftENST00000443378ENST00000394333ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
Frame-shiftENST00000443378ENST00000479035ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
5CDS-5UTRENST00000443378ENST00000245857ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
5CDS-5UTRENST00000443378ENST00000577407ARHGAP23chr17

36638919

+RPL23chr17

37009358

-
intron-intronENST00000431231ENST00000394332ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000431231ENST00000394333ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-5UTRENST00000431231ENST00000479035ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000431231ENST00000245857ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000431231ENST00000577407ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000437668ENST00000394332ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000437668ENST00000394333ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-5UTRENST00000437668ENST00000479035ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000437668ENST00000245857ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000437668ENST00000577407ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000582409ENST00000394332ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000582409ENST00000394333ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-5UTRENST00000582409ENST00000479035ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000582409ENST00000245857ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000582409ENST00000577407ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000443378ENST00000394332ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000443378ENST00000394333ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-5UTRENST00000443378ENST00000479035ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000443378ENST00000245857ARHGAP23chr17

36662177

-RPL23chr17

37009992

-
intron-intronENST00000443378ENST00000577407ARHGAP23chr17

36662177

-RPL23chr17

37009992

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000431231ARHGAP23chr1736638919+ENST00000394332RPL23chr1737009358-357529751730281003
ENST00000437668ARHGAP23chr1736638919+ENST00000394332RPL23chr1737009358-3507290702960986
ENST00000443378ARHGAP23chr1736638919+ENST00000394332RPL23chr1737009358-388732874253340971

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000431231ENST00000394332ARHGAP23chr1736638919+RPL23chr1737009358-0.0043279380.9956721
ENST00000437668ENST00000394332ARHGAP23chr1736638919+RPL23chr1737009358-0.0041793060.99582064
ENST00000443378ENST00000394332ARHGAP23chr1736638919+RPL23chr1737009358-0.0090658980.99093413

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Fusion Genomic Features for ARHGAP23-RPL23


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP23-RPL23


check button Go to

FGviewer for the breakpoints of chr17:36638919-chr17:37009358

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP23

Q9P227

.
FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP23chr17:36638919chr17:37009358ENST00000431231+1624183_279969.01492.0Compositional biasNote=Pro-rich
HgeneARHGAP23chr17:36638919chr17:37009358ENST00000437668+1625183_279969.01145.0Compositional biasNote=Pro-rich
HgeneARHGAP23chr17:36638919chr17:37009358ENST00000431231+1624688_808969.01492.0DomainPH
HgeneARHGAP23chr17:36638919chr17:37009358ENST00000431231+162471_155969.01492.0DomainPDZ
HgeneARHGAP23chr17:36638919chr17:37009358ENST00000437668+1625688_808969.01145.0DomainPH
HgeneARHGAP23chr17:36638919chr17:37009358ENST00000437668+162571_155969.01145.0DomainPDZ

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP23chr17:36638919chr17:37009358ENST00000431231+16241320_1405969.01492.0Compositional biasNote=Arg-rich
HgeneARHGAP23chr17:36638919chr17:37009358ENST00000437668+16251320_1405969.01145.0Compositional biasNote=Arg-rich
HgeneARHGAP23chr17:36638919chr17:37009358ENST00000431231+1624905_1097969.01492.0DomainRho-GAP
HgeneARHGAP23chr17:36638919chr17:37009358ENST00000437668+1625905_1097969.01145.0DomainRho-GAP


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Fusion Gene Sequence for ARHGAP23-RPL23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000431231_ENST00000394332_TCGA-OR-A5KX-01A_ARHGAP23_chr17_36638919_+_RPL23_chr17_37009358_length(transcript)=3575nt_BP=2975nt
CCGCCCCTCCCGGGTCCCTGCCGGCGCCCCCAGCCGTGCCCCGGCCGCAGAGCCGCCGCTGCCACCCGATGAATGGAGTCGCCTTCTGCC
TGGTCGGGATCCCGCCCCGCCCGGAGCCCCGGCCCCCACAGCTGCCACTGGGCCCAAGAGATGGGTGCTCTCCTAGGCGCCCCTTCCCCT
GGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCTTTGGCTTCACTCTGCGCCACTTCATCGTGTACCCACCCGAGT
CGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAGGAGGACCCTCCCCCCGGTACCGCCTGGAGCCCATGGACACCA
TCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGCTTCGCACAGGAGACCGGCTGGTAAAGGTGAATGGGGAAAGCG
TCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTGATGACACTCTGGAGCTGTCTATCATGCCCAAGGACGAGGACA
TCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGCCGTATTCTGGAGAGGCCCGCAGCATCCCAGAGCCACCGCCGA
TCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCAGGGCCACTATGGTGCCTGAGCCCACCTCAGCACTGCCCAGTG
ACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCACCTGCTGCCCGTGCCCACCTGGACAACTCTTCCTTGGGGATGA
GCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGCCCCGGACGCCCCGTGCCTTCCCAGAGCCTGGCAGCCGGGTGC
CCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAAACCAGGTACCCCGCCGGGCGGGGGAGAGACGGTGCCCAGCCA
TGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGGCTGCCCCCCGCCCGTGGCCCTGCTCCACCTCCCAGGATGCTT
TGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACTACTTGAGCCGGGCCACCCGTTCTGCCGAGGCACTGGGGCCAG
GGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGCGTTCGTCTGCCCGCACCCCCGCCTGCCCAACTCGGGACCTGC
CAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACCTCGGGTACATCGGCTACCGGAGCTACAGCCCATCATTCCAGC
GCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTGGGGGGCTGCCTACCTTCAACCTGGCCCAGTCCCCTGCGTCAT
TCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCAGCACCCGGGCCCTGGAGCCTCCTGCGGAGGATCGCGGCGATG
AGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGACCCCCGCAAGACAGATGAACCTTGGATTTGGTGACGAGTCCC
CAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGGCCCCTTTGGCCACCACCGAAGACTCTCTGGCTTCCATCCCCT
TTATTGATGAGCCCACCAGCCCCAGCATTGACCTCCAAGCCAAGCACGTCCCTGCCTCTGCTGTGGTCTCCAGTGCCATGAACTCAGCCC
CTGTCCTGGGCACCAGCCCATCTTCCCCGACCTTCACTTTCACCCTCGGACGCCATTACTCGCAGGACTGCAGCAGCATCAAGGCTGGCC
GCCGCTCCTCCTACCTGCTGGCCATCACCACGGAGCGCTCCAAGTCCTGCGATGATGGACTCAACACCTTCCGCGACGAGGGCCGGGTTC
TGCGGCGCCTGCCAAACCGCATACCCAGCCTGCGGATGCTCCGGAGCTTCTTCACCGACGGGTCCTTGGATAGCTGGGGCACCTCTGAAG
ATGCTGACGCTCCTTCTAAGCGACACTCAACCTCTGACCTCTCAGATGCGACCTTCAGCGATATCAGGAGAGAAGGCTGGTTGTATTATA
AGCAGATTCTCACCAAGAAGGGGAAGAAAGCGGGCAGCGGCCTGCGCCAGTGGAAGCGGGTGTACGCCGCGCTGCGGGCGCGCTCGCTCT
CGCTGAGCAAGGAGCGGCGGGAGCCCGGGCCGGCGGCGGCGGGGGCTGCGGCGGCCGGCGCAGGTGAGGACGAGGCGGCGCCCGTCTGCA
TCGGCTCCTGCCTCGTGGACATCTCCTACAGCGAGACCAAGAGGAGGCACGTGTTCCGGCTGACCACCGCTGACTTCTGTGAATATCTCT
TTCAGGCTGAGGACCGGGATGACATGCTGGGCTGGATCAGAGCGATCCGGGAGAACAGCAGGGCCGAGGGCGAGGACCCCGGCTGTGCCA
ACCAAGCTCTGATCAGCAAGAAGCTTAACGATTATCGCAAAGTGAGCCATAGCTCTGGGCCCAAAGCTGATTCCTCCCCCAAAGGCTCTC
GCGGCCTGGGGGGCCTCAAGTCTGAGTTCCTCAAGCAGAGTGCGGCACGTGGCCTCAGGACTCAGGACCTGCCCGCAGGGAGCAAGGATG
ACAGTGCTGCAGCCCCCAAAACCCCCTGGGGCATCAACATCATCAAGAAAAATAAGAAGGCCGCTCCGAGGGCGTTTGGGGTCAGGCTGG
AGGAGTGCCAGCCAGCCACGGAGAACCAGCGCGTCCCCTTAATCGTGGCTGCATGCTGTCGCATTGTGGAGGCACGAGGGCTGGAGTCCA
CAGGCATTTACCGAGTGCCCGGCAACAATGCAGTGGTGTCCAGCCTACAGGAGCAGCTCAACCGCGGGCCTGGTGACATCAACCTGCAGG
ATGAGGACGTGGTGGGTCCTCTGGTGCGAAATTCCGGATTTCCTTGGGTCTTCCGGTAGGAGCTGTAATCAATTGTGCTGACAACACAGG
AGCCAAAAACCTGTATATCATCTCCGTGAAGGGGATCAAGGGACGGCTGAACAGACTTCCCGCTGCTGGTGTGGGTGACATGGTGATGGC
CACAGTCAAGAAAGGCAAACCAGAGCTCAGAAAAAAGGTACATCCAGCAGTGGTCATTCGACAACGAAAGTCATACCGTAGAAAAGATGG
CGTGTTTCTTTATTTTGAAGATAATGCAGGAGTCATAGTGAACAATAAAGGCGAGATGAAAGGTTCTGCCATTACAGGACCAGTAGCAAA
GGAGTGTGCAGACTTGTGGCCCCGGATTGCATCCAATGCTGGCAGCATTGCATGATTCTCCAGTATATTTGCTGGAGTGCAGTAACACCA
CTGAAGCTCACTGTAACTTTGAACTGCTGGACTTGGAATCCTCCTGCTGTGGCCTTCAAAGGGCTGCAATTACAAGTGTGAGCCACTGCA

>In-frame_ENST00000431231_ENST00000394332_TCGA-OR-A5KX-01A_ARHGAP23_chr17_36638919_+_RPL23_chr17_37009358_length(amino acids)=1003AA_start in transcript=17_stop in transcript=3028
MPAPPAVPRPQSRRCHPMNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCS
LKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAY
SQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPS
PGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQ
EGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLL
HALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEAS
GRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYL
LAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTK
KGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDR
DDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAP
KTPWGINIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDEDVVG

--------------------------------------------------------------
>In-frame_ENST00000437668_ENST00000394332_TCGA-OR-A5KX-01A_ARHGAP23_chr17_36638919_+_RPL23_chr17_37009358_length(transcript)=3507nt_BP=2907nt
ATGAATGGAGTCGCCTTCTGCCTGGTCGGGATCCCGCCCCGCCCGGAGCCCCGGCCCCCACAGCTGCCACTGGGCCCAAGAGATGGGTGC
TCTCCTAGGCGCCCCTTCCCCTGGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCTTTGGCTTCACTCTGCGCCAC
TTCATCGTGTACCCACCCGAGTCGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAGGAGGACCCTCCCCCCGGTAC
CGCCTGGAGCCCATGGACACCATCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGCTTCGCACAGGAGACCGGCTG
GTAAAGGTGAATGGGGAAAGCGTCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTGATGACACTCTGGAGCTGTCT
ATCATGCCCAAGGACGAGGACATCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGCCGTATTCTGGAGAGGCCCGC
AGCATCCCAGAGCCACCGCCGATCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCAGGGCCACTATGGTGCCTGAG
CCCACCTCAGCACTGCCCAGTGACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCACCTGCTGCCCGTGCCCACCTG
GACAACTCTTCCTTGGGGATGAGCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGCCCCGGACGCCCCGTGCCTTC
CCAGAGCCTGGCAGCCGGGTGCCCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAAACCAGGTACCCCGCCGGGCG
GGGGAGAGACGGTGCCCAGCCATGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGGCTGCCCCCCGCCCGTGGCCC
TGCTCCACCTCCCAGGATGCTTTGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACTACTTGAGCCGGGCCACCCGT
TCTGCCGAGGCACTGGGGCCAGGGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGCGTTCGTCTGCCCGCACCCCC
GCCTGCCCAACTCGGGACCTGCCAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACCTCGGGTACATCGGCTACCGG
AGCTACAGCCCATCATTCCAGCGCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTGGGGGGCTGCCTACCTTCAAC
CTGGCCCAGTCCCCTGCGTCATTCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCAGCACCCGGGCCCTGGAGCCT
CCTGCGGAGGATCGCGGCGATGAGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGACCCCCGCAAGACAGATGAAC
CTTGGATTTGGTGACGAGTCCCCAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGGCCCCTTTGGCCACCACCGAA
GACTCTCTGGCTTCCATCCCCTTTATTGATGAGCCCACCAGCCCCAGCATTGACCTCCAAGCCAAGCACGTCCCTGCCTCTGCTGTGGTC
TCCAGTGCCATGAACTCAGCCCCTGTCCTGGGCACCAGCCCATCTTCCCCGACCTTCACTTTCACCCTCGGACGCCATTACTCGCAGGAC
TGCAGCAGCATCAAGGCTGGCCGCCGCTCCTCCTACCTGCTGGCCATCACCACGGAGCGCTCCAAGTCCTGCGATGATGGACTCAACACC
TTCCGCGACGAGGGCCGGGTTCTGCGGCGCCTGCCAAACCGCATACCCAGCCTGCGGATGCTCCGGAGCTTCTTCACCGACGGGTCCTTG
GATAGCTGGGGCACCTCTGAAGATGCTGACGCTCCTTCTAAGCGACACTCAACCTCTGACCTCTCAGATGCGACCTTCAGCGATATCAGG
AGAGAAGGCTGGTTGTATTATAAGCAGATTCTCACCAAGAAGGGGAAGAAAGCGGGCAGCGGCCTGCGCCAGTGGAAGCGGGTGTACGCC
GCGCTGCGGGCGCGCTCGCTCTCGCTGAGCAAGGAGCGGCGGGAGCCCGGGCCGGCGGCGGCGGGGGCTGCGGCGGCCGGCGCAGGTGAG
GACGAGGCGGCGCCCGTCTGCATCGGCTCCTGCCTCGTGGACATCTCCTACAGCGAGACCAAGAGGAGGCACGTGTTCCGGCTGACCACC
GCTGACTTCTGTGAATATCTCTTTCAGGCTGAGGACCGGGATGACATGCTGGGCTGGATCAGAGCGATCCGGGAGAACAGCAGGGCCGAG
GGCGAGGACCCCGGCTGTGCCAACCAAGCTCTGATCAGCAAGAAGCTTAACGATTATCGCAAAGTGAGCCATAGCTCTGGGCCCAAAGCT
GATTCCTCCCCCAAAGGCTCTCGCGGCCTGGGGGGCCTCAAGTCTGAGTTCCTCAAGCAGAGTGCGGCACGTGGCCTCAGGACTCAGGAC
CTGCCCGCAGGGAGCAAGGATGACAGTGCTGCAGCCCCCAAAACCCCCTGGGGCATCAACATCATCAAGAAAAATAAGAAGGCCGCTCCG
AGGGCGTTTGGGGTCAGGCTGGAGGAGTGCCAGCCAGCCACGGAGAACCAGCGCGTCCCCTTAATCGTGGCTGCATGCTGTCGCATTGTG
GAGGCACGAGGGCTGGAGTCCACAGGCATTTACCGAGTGCCCGGCAACAATGCAGTGGTGTCCAGCCTACAGGAGCAGCTCAACCGCGGG
CCTGGTGACATCAACCTGCAGGATGAGGACGTGGTGGGTCCTCTGGTGCGAAATTCCGGATTTCCTTGGGTCTTCCGGTAGGAGCTGTAA
TCAATTGTGCTGACAACACAGGAGCCAAAAACCTGTATATCATCTCCGTGAAGGGGATCAAGGGACGGCTGAACAGACTTCCCGCTGCTG
GTGTGGGTGACATGGTGATGGCCACAGTCAAGAAAGGCAAACCAGAGCTCAGAAAAAAGGTACATCCAGCAGTGGTCATTCGACAACGAA
AGTCATACCGTAGAAAAGATGGCGTGTTTCTTTATTTTGAAGATAATGCAGGAGTCATAGTGAACAATAAAGGCGAGATGAAAGGTTCTG
CCATTACAGGACCAGTAGCAAAGGAGTGTGCAGACTTGTGGCCCCGGATTGCATCCAATGCTGGCAGCATTGCATGATTCTCCAGTATAT
TTGCTGGAGTGCAGTAACACCACTGAAGCTCACTGTAACTTTGAACTGCTGGACTTGGAATCCTCCTGCTGTGGCCTTCAAAGGGCTGCA

>In-frame_ENST00000437668_ENST00000394332_TCGA-OR-A5KX-01A_ARHGAP23_chr17_36638919_+_RPL23_chr17_37009358_length(amino acids)=986AA_start in transcript=0_stop in transcript=2960
MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRY
RLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR
SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAF
PEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR
SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFN
LAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE
DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNT
FRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA
ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAE
GEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP

--------------------------------------------------------------
>In-frame_ENST00000443378_ENST00000394332_TCGA-OR-A5KX-01A_ARHGAP23_chr17_36638919_+_RPL23_chr17_37009358_length(transcript)=3887nt_BP=3287nt
GAAGGATGCGTGTGTGCCGGTCTGCTGTGCATGTGTGTATCTGCATGTCTGTGATGCATGCGCATGCGTCTGTATGTGCATTGTGTGTGC
AGGACTTTGATTCTGTGCAACTCTGTGCATATCTATGTGTCTACAAAAGTGTGCACATGTGTACTCATTTGTGTGTGTGTATCTGTGTGT
CTGCATATTTGCACATGCTTGTCTGTATGTTTGTGGTATGTTCCGTCTACATGAGTGTATGTGGCTGGGGCTGTGTCTGCATAAGTATGT
GTCTATCTGGGAGTGCATATATGTGTGCATGTGTGTGTGTGAGATTGTGCATGAGCTAAGACAACGACAGGCACTTCCTGGGCAGGAAGG
CTGTATCCAGGGTCCTGCACATAGTAGGTGCTCAGTGAACATTTGCTGAACTCAGCTGAACTGAACTGAATGAACTTGCTTCACTGCCAC
TGGGCCCAAGAGATGGGTGCTCTCCTAGGCGCCCCTTCCCCTGGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCT
TTGGCTTCACTCTGCGCCACTTCATCGTGTACCCACCCGAGTCGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAG
GAGGACCCTCCCCCCGGTACCGCCTGGAGCCCATGGACACCATCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGC
TTCGCACAGGAGACCGGCTGGTAAAGGTGAATGGGGAAAGCGTCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTG
ATGACACTCTGGAGCTGTCTATCATGCCCAAGGACGAGGACATCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGC
CGTATTCTGGAGAGGCCCGCAGCATCCCAGAGCCACCGCCGATCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCA
GGGCCACTATGGTGCCTGAGCCCACCTCAGCACTGCCCAGTGACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCAC
CTGCTGCCCGTGCCCACCTGGACAACTCTTCCTTGGGGATGAGCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGC
CCCGGACGCCCCGTGCCTTCCCAGAGCCTGGCAGCCGGGTGCCCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAA
ACCAGGTACCCCGCCGGGCGGGGGAGAGACGGTGCCCAGCCATGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGG
CTGCCCCCCGCCCGTGGCCCTGCTCCACCTCCCAGGATGCTTTGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACT
ACTTGAGCCGGGCCACCCGTTCTGCCGAGGCACTGGGGCCAGGGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGC
GTTCGTCTGCCCGCACCCCCGCCTGCCCAACTCGGGACCTGCCAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACC
TCGGGTACATCGGCTACCGGAGCTACAGCCCATCATTCCAGCGCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTG
GGGGGCTGCCTACCTTCAACCTGGCCCAGTCCCCTGCGTCATTCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCA
GCACCCGGGCCCTGGAGCCTCCTGCGGAGGATCGCGGCGATGAGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGA
CCCCCGCAAGACAGATGAACCTTGGATTTGGTGACGAGTCCCCAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGG
CCCCTTTGGCCACCACCGAAGACTCTCTGGCTTCCATCCCCTTTATTGATGAGCCCACCAGCCCCAGCATTGACCTCCAAGCCAAGCACG
TCCCTGCCTCTGCTGTGGTCTCCAGTGCCATGAACTCAGCCCCTGTCCTGGGCACCAGCCCATCTTCCCCGACCTTCACTTTCACCCTCG
GACGCCATTACTCGCAGGACTGCAGCAGCATCAAGGCTGGCCGCCGCTCCTCCTACCTGCTGGCCATCACCACGGAGCGCTCCAAGTCCT
GCGATGATGGACTCAACACCTTCCGCGACGAGGGCCGGGTTCTGCGGCGCCTGCCAAACCGCATACCCAGCCTGCGGATGCTCCGGAGCT
TCTTCACCGACGGGTCCTTGGATAGCTGGGGCACCTCTGAAGATGCTGACGCTCCTTCTAAGCGACACTCAACCTCTGACCTCTCAGATG
CGACCTTCAGCGATATCAGGAGAGAAGGCTGGTTGTATTATAAGCAGATTCTCACCAAGAAGGGGAAGAAAGCGGGCAGCGGCCTGCGCC
AGTGGAAGCGGGTGTACGCCGCGCTGCGGGCGCGCTCGCTCTCGCTGAGCAAGGAGCGGCGGGAGCCCGGGCCGGCGGCGGCGGGGGCTG
CGGCGGCCGGCGCAGGTGAGGACGAGGCGGCGCCCGTCTGCATCGGCTCCTGCCTCGTGGACATCTCCTACAGCGAGACCAAGAGGAGGC
ACGTGTTCCGGCTGACCACCGCTGACTTCTGTGAATATCTCTTTCAGGCTGAGGACCGGGATGACATGCTGGGCTGGATCAGAGCGATCC
GGGAGAACAGCAGGGCCGAGGGCGAGGACCCCGGCTGTGCCAACCAAGCTCTGATCAGCAAGAAGCTTAACGATTATCGCAAAGTGAGCC
ATAGCTCTGGGCCCAAAGCTGATTCCTCCCCCAAAGGCTCTCGCGGCCTGGGGGGCCTCAAGTCTGAGTTCCTCAAGCAGAGTGCGGCAC
GTGGCCTCAGGACTCAGGACCTGCCCGCAGGGAGCAAGGATGACAGTGCTGCAGCCCCCAAAACCCCCTGGGGCATCAACATCATCAAGA
AAAATAAGAAGGCCGCTCCGAGGGCGTTTGGGGTCAGGCTGGAGGAGTGCCAGCCAGCCACGGAGAACCAGCGCGTCCCCTTAATCGTGG
CTGCATGCTGTCGCATTGTGGAGGCACGAGGGCTGGAGTCCACAGGCATTTACCGAGTGCCCGGCAACAATGCAGTGGTGTCCAGCCTAC
AGGAGCAGCTCAACCGCGGGCCTGGTGACATCAACCTGCAGGATGAGGACGTGGTGGGTCCTCTGGTGCGAAATTCCGGATTTCCTTGGG
TCTTCCGGTAGGAGCTGTAATCAATTGTGCTGACAACACAGGAGCCAAAAACCTGTATATCATCTCCGTGAAGGGGATCAAGGGACGGCT
GAACAGACTTCCCGCTGCTGGTGTGGGTGACATGGTGATGGCCACAGTCAAGAAAGGCAAACCAGAGCTCAGAAAAAAGGTACATCCAGC
AGTGGTCATTCGACAACGAAAGTCATACCGTAGAAAAGATGGCGTGTTTCTTTATTTTGAAGATAATGCAGGAGTCATAGTGAACAATAA
AGGCGAGATGAAAGGTTCTGCCATTACAGGACCAGTAGCAAAGGAGTGTGCAGACTTGTGGCCCCGGATTGCATCCAATGCTGGCAGCAT
TGCATGATTCTCCAGTATATTTGCTGGAGTGCAGTAACACCACTGAAGCTCACTGTAACTTTGAACTGCTGGACTTGGAATCCTCCTGCT
GTGGCCTTCAAAGGGCTGCAATTACAAGTGTGAGCCACTGCATCCCACCTCACATTTTATTCTTTGGAGATTTTTTTTGACTTGGATTAA

>In-frame_ENST00000443378_ENST00000394332_TCGA-OR-A5KX-01A_ARHGAP23_chr17_36638919_+_RPL23_chr17_37009358_length(amino acids)=971AA_start in transcript=425_stop in transcript=3340
MNELASLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKE
DGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTY
APPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQ
QALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRF
ERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEP
PRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSP
SIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRI
PSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERRE
PGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKK
LNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP23-RPL23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP23-RPL23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP23-RPL23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP23C0032460Polycystic Ovary Syndrome1CTD_human
HgeneARHGAP23C1136382Sclerocystic Ovaries1CTD_human
TgeneRPL23C1260899Anemia, Diamond-Blackfan1GENOMICS_ENGLAND