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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP24-PPA2 (FusionGDB2 ID:6123)

Fusion Gene Summary for ARHGAP24-PPA2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP24-PPA2
Fusion gene ID: 6123
HgeneTgene
Gene symbol

ARHGAP24

PPA2

Gene ID

83478

27068

Gene nameRho GTPase activating protein 24inorganic pyrophosphatase 2
SynonymsFILGAP|RC-GAP72|RCGAP72|p73|p73RhoGAPHSPC124|SCFAI|SCFI|SID6-306
Cytomap

4q21.23-q21.3

4q24

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 24RAC1- and CDC42-specific GTPase-activating protein of 72 kDafilamin-A-associated RhoGAPrhoGAP of 73 kDasarcoma antigen NY-SAR-88inorganic pyrophosphatase 2, mitochondrialPPase 2pyrophosphatase (inorganic) 2pyrophosphatase SID6-306pyrophosphate phospho-hydrolase 2
Modification date2020031320200313
UniProtAcc

Q8N264

.
Ensembl transtripts involved in fusion geneENST00000395184, ENST00000503995, 
ENST00000506421, ENST00000395183, 
ENST00000264343, 		ENST00000341695, 
ENST00000348706, ENST00000432483, 
ENST00000354147, ENST00000380004, 
ENST00000357415, ENST00000509426, 
ENST00000310267, 
Fusion gene scores* DoF score11 X 10 X 6=66017 X 10 X 8=1360
# samples 1418
** MAII scorelog2(14/660*10)=-2.23703919730085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1360*10)=-2.91753783980803
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP24 [Title/Abstract] AND PPA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP24(86491874)-PPA2(106345479), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PPA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer135NARHGAP24chr4

86491874

+PPA2chr4

106345479

-


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Fusion Gene ORF analysis for ARHGAP24-PPA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000395184ENST00000341695ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
In-frameENST00000395184ENST00000348706ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
In-frameENST00000395184ENST00000432483ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
5CDS-intronENST00000395184ENST00000354147ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
5CDS-intronENST00000395184ENST00000380004ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
5CDS-intronENST00000395184ENST00000357415ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
5CDS-5UTRENST00000395184ENST00000509426ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
5CDS-5UTRENST00000395184ENST00000310267ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
In-frameENST00000503995ENST00000341695ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
In-frameENST00000503995ENST00000348706ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
In-frameENST00000503995ENST00000432483ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
5CDS-intronENST00000503995ENST00000354147ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
5CDS-intronENST00000503995ENST00000380004ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
5CDS-intronENST00000503995ENST00000357415ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
5CDS-5UTRENST00000503995ENST00000509426ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
5CDS-5UTRENST00000503995ENST00000310267ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
3UTR-3CDSENST00000506421ENST00000341695ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
3UTR-3CDSENST00000506421ENST00000348706ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
3UTR-3CDSENST00000506421ENST00000432483ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
3UTR-intronENST00000506421ENST00000354147ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
3UTR-intronENST00000506421ENST00000380004ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
3UTR-intronENST00000506421ENST00000357415ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
3UTR-5UTRENST00000506421ENST00000509426ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
3UTR-5UTRENST00000506421ENST00000310267ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-3CDSENST00000395183ENST00000341695ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-3CDSENST00000395183ENST00000348706ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-3CDSENST00000395183ENST00000432483ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-intronENST00000395183ENST00000354147ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-intronENST00000395183ENST00000380004ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-intronENST00000395183ENST00000357415ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-5UTRENST00000395183ENST00000509426ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-5UTRENST00000395183ENST00000310267ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-3CDSENST00000264343ENST00000341695ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-3CDSENST00000264343ENST00000348706ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-3CDSENST00000264343ENST00000432483ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-intronENST00000264343ENST00000354147ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-intronENST00000264343ENST00000380004ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-intronENST00000264343ENST00000357415ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-5UTRENST00000264343ENST00000509426ARHGAP24chr4

86491874

+PPA2chr4

106345479

-
intron-5UTRENST00000264343ENST00000310267ARHGAP24chr4

86491874

+PPA2chr4

106345479

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395184ARHGAP24chr486491874+ENST00000341695PPA2chr4106345479-17716462801122280
ENST00000395184ARHGAP24chr486491874+ENST00000348706PPA2chr4106345479-16056462801122280
ENST00000395184ARHGAP24chr486491874+ENST00000432483PPA2chr4106345479-12836462801122280
ENST00000503995ARHGAP24chr486491874+ENST00000341695PPA2chr4106345479-1647522156998280
ENST00000503995ARHGAP24chr486491874+ENST00000348706PPA2chr4106345479-1481522156998280
ENST00000503995ARHGAP24chr486491874+ENST00000432483PPA2chr4106345479-1159522156998280

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395184ENST00000341695ARHGAP24chr486491874+PPA2chr4106345479-0.0053942940.9946057
ENST00000395184ENST00000348706ARHGAP24chr486491874+PPA2chr4106345479-0.0067595090.9932405
ENST00000395184ENST00000432483ARHGAP24chr486491874+PPA2chr4106345479-0.0052132670.99478674
ENST00000503995ENST00000341695ARHGAP24chr486491874+PPA2chr4106345479-0.0048221530.99517787
ENST00000503995ENST00000348706ARHGAP24chr486491874+PPA2chr4106345479-0.0071221030.9928779
ENST00000503995ENST00000432483ARHGAP24chr486491874+PPA2chr4106345479-0.0049702710.99502975

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Fusion Genomic Features for ARHGAP24-PPA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP24-PPA2


check button Go to

FGviewer for the breakpoints of chr4:86491874-chr4:106345479

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP24

Q8N264

.
FUNCTION: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP24chr4:86491874chr4:106345479ENST00000264343+17649_7290656.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86491874chr4:106345479ENST00000395183+18649_7290654.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86491874chr4:106345479ENST00000395184+210649_72960.0749.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86491874chr4:106345479ENST00000503995+26649_72960.0247.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86491874chr4:106345479ENST00000264343+17135_3290656.0DomainRho-GAP
HgeneARHGAP24chr4:86491874chr4:106345479ENST00000264343+1719_1250656.0DomainPH
HgeneARHGAP24chr4:86491874chr4:106345479ENST00000395183+18135_3290654.0DomainRho-GAP
HgeneARHGAP24chr4:86491874chr4:106345479ENST00000395183+1819_1250654.0DomainPH
HgeneARHGAP24chr4:86491874chr4:106345479ENST00000395184+210135_32960.0749.0DomainRho-GAP
HgeneARHGAP24chr4:86491874chr4:106345479ENST00000395184+21019_12560.0749.0DomainPH
HgeneARHGAP24chr4:86491874chr4:106345479ENST00000503995+26135_32960.0247.0DomainRho-GAP
HgeneARHGAP24chr4:86491874chr4:106345479ENST00000503995+2619_12560.0247.0DomainPH


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Fusion Gene Sequence for ARHGAP24-PPA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000395184_ENST00000341695_135N_ARHGAP24_chr4_86491874_+_PPA2_chr4_106345479_length(transcript)=1771nt_BP=646nt
TTGTACTGTATATTTACACATTCACACACAATCACCCTTTCTAACTTCTGGGACTCTTTGCGCAACTGCTAGGATTTCTCAAGTGCATGT
GGCAACACAGCCCAGCTCCGGGTGGAAACCAGCAGGGCTCTGGAGGGGCTCGGAGACCAGGGGAGCTGTCAAGGCTGCGGCGGGGACCAG
AGAGGAGCCTGGCGGGGGTGGCTGGGTGGCTGGGGGAATCCCCCCAACTTCCCATCGCAGGCGCAGCTCTCTCGGCCGCCTATTTCCTCC
GAAACCCGCGCTGCGGAGCAGCCCAGTGCATAGAGTTCAACACTTCCCCTTGTTGTGGAAAGTAAAGGAGCCTCACTACCACCTTTTTTT
CTTTGCGTTTTCTTACTGCTGGTCCTGGGAGCCTTTTCCTTCGGAGCAGCAGCCCTGTCCGGCATCTGTCTTGAGCTCCCAGCAAGGAAA
GTCCATCAGCTTGATAATGGAGGAGAACAATGACTCCACGGAGAACCCCCAACAAGGCCAAGGGCGGCAGAATGCCATCAAGTGTGGGTG
GCTGAGGAAGCAAGGAGGCTTTGTCAAGACTTGGCATACTCGCTGGTTTGTGCTCAAGGGGGATCAGCTCTATTATTTCAAAGATGAAGA
TGAAACCAAGCCCTTGATTCTTTCTTGTGGAGAAGTTATTCATGTGAAGATCCTTGGAATTTTGGCTCTTATTGATGAAGGTGAAACAGA
TTGGAAATTAATTGCTATCAATGCGAATGATCCTGAAGCCTCAAAGTTTCATGATATTGATGATGTTAAGAAGTTCAAACCGGGTTACCT
GGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAACAA
GGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATGGAGGAGCTATAAATTGCAC
AAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCATCTTCACCAAATAAAGA
AAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAGATTCCCATCTCTAAGGACT
CCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTTTTTGAGCTATGCAATATAT
AAATAAACAGTAAGAATTTTAAATTACTCTCCTTTGGACATTTATTGATATAAAAAGAAGATTTTGGCCAGGCACGGTGGCTCATGCCTG
TAATTTCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAGTATGTTGAAACCCCATCTCT
ATTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGACCCAGCTACTCAGGAGGCTGAGGCAGAAGAACTGCTTGAGCCC
AGGAGGCAGAGGTTGCAGTGAGCAGAGATTGTGCCACTGCACTCCAGCCTAGGCGACAGAGAGAGACTCCGTCTCAAAAAAAAAAAAAAG
ATTTTGTTTCATTTCATAGCACAAATTTAGAGGCATTGAGTTGACCATTTCTAGTTTCTATACCTGAAGGAACCCATTGATTTTACCAGT

>In-frame_ENST00000395184_ENST00000341695_135N_ARHGAP24_chr4_86491874_+_PPA2_chr4_106345479_length(amino acids)=280AA_start in transcript=280_stop in transcript=1122
MRSSPVHRVQHFPLLWKVKEPHYHLFFFAFSYCWSWEPFPSEQQPCPASVLSSQQGKSISLIMEENNDSTENPQQGQGRQNAIKCGWLRK
QGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEAT
LNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNE

--------------------------------------------------------------
>In-frame_ENST00000395184_ENST00000348706_135N_ARHGAP24_chr4_86491874_+_PPA2_chr4_106345479_length(transcript)=1605nt_BP=646nt
TTGTACTGTATATTTACACATTCACACACAATCACCCTTTCTAACTTCTGGGACTCTTTGCGCAACTGCTAGGATTTCTCAAGTGCATGT
GGCAACACAGCCCAGCTCCGGGTGGAAACCAGCAGGGCTCTGGAGGGGCTCGGAGACCAGGGGAGCTGTCAAGGCTGCGGCGGGGACCAG
AGAGGAGCCTGGCGGGGGTGGCTGGGTGGCTGGGGGAATCCCCCCAACTTCCCATCGCAGGCGCAGCTCTCTCGGCCGCCTATTTCCTCC
GAAACCCGCGCTGCGGAGCAGCCCAGTGCATAGAGTTCAACACTTCCCCTTGTTGTGGAAAGTAAAGGAGCCTCACTACCACCTTTTTTT
CTTTGCGTTTTCTTACTGCTGGTCCTGGGAGCCTTTTCCTTCGGAGCAGCAGCCCTGTCCGGCATCTGTCTTGAGCTCCCAGCAAGGAAA
GTCCATCAGCTTGATAATGGAGGAGAACAATGACTCCACGGAGAACCCCCAACAAGGCCAAGGGCGGCAGAATGCCATCAAGTGTGGGTG
GCTGAGGAAGCAAGGAGGCTTTGTCAAGACTTGGCATACTCGCTGGTTTGTGCTCAAGGGGGATCAGCTCTATTATTTCAAAGATGAAGA
TGAAACCAAGCCCTTGATTCTTTCTTGTGGAGAAGTTATTCATGTGAAGATCCTTGGAATTTTGGCTCTTATTGATGAAGGTGAAACAGA
TTGGAAATTAATTGCTATCAATGCGAATGATCCTGAAGCCTCAAAGTTTCATGATATTGATGATGTTAAGAAGTTCAAACCGGGTTACCT
GGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAACAA
GGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATGGAGGAGCTATAAATTGCAC
AAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCATCTTCACCAAATAAAGA
AAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAGATTCCCATCTCTAAGGACT
CCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTTTTTGAGCTATGCAATATAT
AAATAAACAGTAAGAATTTTAAATTACTCTCCTTTGGACATTTATTGATATAAAAAGAAGATTTTGGCCAGGCACGGTGGCTCATGCCTG
TAATTTCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAGTATGTTGAAACCCCATCTCT
ATTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGACCCAGCTACTCAGGAGGCTGAGGCAGAAGAACTGCTTGAGCCC

>In-frame_ENST00000395184_ENST00000348706_135N_ARHGAP24_chr4_86491874_+_PPA2_chr4_106345479_length(amino acids)=280AA_start in transcript=280_stop in transcript=1122
MRSSPVHRVQHFPLLWKVKEPHYHLFFFAFSYCWSWEPFPSEQQPCPASVLSSQQGKSISLIMEENNDSTENPQQGQGRQNAIKCGWLRK
QGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEAT
LNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNE

--------------------------------------------------------------
>In-frame_ENST00000395184_ENST00000432483_135N_ARHGAP24_chr4_86491874_+_PPA2_chr4_106345479_length(transcript)=1283nt_BP=646nt
TTGTACTGTATATTTACACATTCACACACAATCACCCTTTCTAACTTCTGGGACTCTTTGCGCAACTGCTAGGATTTCTCAAGTGCATGT
GGCAACACAGCCCAGCTCCGGGTGGAAACCAGCAGGGCTCTGGAGGGGCTCGGAGACCAGGGGAGCTGTCAAGGCTGCGGCGGGGACCAG
AGAGGAGCCTGGCGGGGGTGGCTGGGTGGCTGGGGGAATCCCCCCAACTTCCCATCGCAGGCGCAGCTCTCTCGGCCGCCTATTTCCTCC
GAAACCCGCGCTGCGGAGCAGCCCAGTGCATAGAGTTCAACACTTCCCCTTGTTGTGGAAAGTAAAGGAGCCTCACTACCACCTTTTTTT
CTTTGCGTTTTCTTACTGCTGGTCCTGGGAGCCTTTTCCTTCGGAGCAGCAGCCCTGTCCGGCATCTGTCTTGAGCTCCCAGCAAGGAAA
GTCCATCAGCTTGATAATGGAGGAGAACAATGACTCCACGGAGAACCCCCAACAAGGCCAAGGGCGGCAGAATGCCATCAAGTGTGGGTG
GCTGAGGAAGCAAGGAGGCTTTGTCAAGACTTGGCATACTCGCTGGTTTGTGCTCAAGGGGGATCAGCTCTATTATTTCAAAGATGAAGA
TGAAACCAAGCCCTTGATTCTTTCTTGTGGAGAAGTTATTCATGTGAAGATCCTTGGAATTTTGGCTCTTATTGATGAAGGTGAAACAGA
TTGGAAATTAATTGCTATCAATGCGAATGATCCTGAAGCCTCAAAGTTTCATGATATTGATGATGTTAAGAAGTTCAAACCGGGTTACCT
GGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAACAA
GGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATGGAGGAGCTATAAATTGCAC
AAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCATCTTCACCAAATAAAGA
AAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAGATTCCCATCTCTAAGGACT
CCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTTTTTGAGCTATGCAATATAT

>In-frame_ENST00000395184_ENST00000432483_135N_ARHGAP24_chr4_86491874_+_PPA2_chr4_106345479_length(amino acids)=280AA_start in transcript=280_stop in transcript=1122
MRSSPVHRVQHFPLLWKVKEPHYHLFFFAFSYCWSWEPFPSEQQPCPASVLSSQQGKSISLIMEENNDSTENPQQGQGRQNAIKCGWLRK
QGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEAT
LNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNE

--------------------------------------------------------------
>In-frame_ENST00000503995_ENST00000341695_135N_ARHGAP24_chr4_86491874_+_PPA2_chr4_106345479_length(transcript)=1647nt_BP=522nt
GGGCTCTGGAGGGGCTCGGAGACCAGGGGAGCTGTCAAGGCTGCGGCGGGGACCAGAGAGGAGCCTGGCGGGGGTGGCTGGGTGGCTGGG
GGAATCCCCCCAACTTCCCATCGCAGGCGCAGCTCTCTCGGCCGCCTATTTCCTCCGAAACCCGCGCTGCGGAGCAGCCCAGTGCATAGA
GTTCAACACTTCCCCTTGTTGTGGAAAGTAAAGGAGCCTCACTACCACCTTTTTTTCTTTGCGTTTTCTTACTGCTGGTCCTGGGAGCCT
TTTCCTTCGGAGCAGCAGCCCTGTCCGGCATCTGTCTTGAGCTCCCAGCAAGGAAAGTCCATCAGCTTGATAATGGAGGAGAACAATGAC
TCCACGGAGAACCCCCAACAAGGCCAAGGGCGGCAGAATGCCATCAAGTGTGGGTGGCTGAGGAAGCAAGGAGGCTTTGTCAAGACTTGG
CATACTCGCTGGTTTGTGCTCAAGGGGGATCAGCTCTATTATTTCAAAGATGAAGATGAAACCAAGCCCTTGATTCTTTCTTGTGGAGAA
GTTATTCATGTGAAGATCCTTGGAATTTTGGCTCTTATTGATGAAGGTGAAACAGATTGGAAATTAATTGCTATCAATGCGAATGATCCT
GAAGCCTCAAAGTTTCATGATATTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAG
GTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCAT
CAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGC
ACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTT
GGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATT
TACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTTTTTGAGCTATGCAATATATAAATAAACAGTAAGAATTTTAAATTACTCTCCTT
TGGACATTTATTGATATAAAAAGAAGATTTTGGCCAGGCACGGTGGCTCATGCCTGTAATTTCAGCACTTTGGGAGGCCGAGGTGGGCAG
ATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAGTATGTTGAAACCCCATCTCTATTAAAAATACAAAAATTAGCCAGGCGTGGTGGT
GCATGCCTGTAGACCCAGCTACTCAGGAGGCTGAGGCAGAAGAACTGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCAGAGATTGTGC
CACTGCACTCCAGCCTAGGCGACAGAGAGAGACTCCGTCTCAAAAAAAAAAAAAAGATTTTGTTTCATTTCATAGCACAAATTTAGAGGC
ATTGAGTTGACCATTTCTAGTTTCTATACCTGAAGGAACCCATTGATTTTACCAGTTTTTATTTCTGTAGATTGGATGTAAAAATCACAG

>In-frame_ENST00000503995_ENST00000341695_135N_ARHGAP24_chr4_86491874_+_PPA2_chr4_106345479_length(amino acids)=280AA_start in transcript=156_stop in transcript=998
MRSSPVHRVQHFPLLWKVKEPHYHLFFFAFSYCWSWEPFPSEQQPCPASVLSSQQGKSISLIMEENNDSTENPQQGQGRQNAIKCGWLRK
QGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEAT
LNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNE

--------------------------------------------------------------
>In-frame_ENST00000503995_ENST00000348706_135N_ARHGAP24_chr4_86491874_+_PPA2_chr4_106345479_length(transcript)=1481nt_BP=522nt
GGGCTCTGGAGGGGCTCGGAGACCAGGGGAGCTGTCAAGGCTGCGGCGGGGACCAGAGAGGAGCCTGGCGGGGGTGGCTGGGTGGCTGGG
GGAATCCCCCCAACTTCCCATCGCAGGCGCAGCTCTCTCGGCCGCCTATTTCCTCCGAAACCCGCGCTGCGGAGCAGCCCAGTGCATAGA
GTTCAACACTTCCCCTTGTTGTGGAAAGTAAAGGAGCCTCACTACCACCTTTTTTTCTTTGCGTTTTCTTACTGCTGGTCCTGGGAGCCT
TTTCCTTCGGAGCAGCAGCCCTGTCCGGCATCTGTCTTGAGCTCCCAGCAAGGAAAGTCCATCAGCTTGATAATGGAGGAGAACAATGAC
TCCACGGAGAACCCCCAACAAGGCCAAGGGCGGCAGAATGCCATCAAGTGTGGGTGGCTGAGGAAGCAAGGAGGCTTTGTCAAGACTTGG
CATACTCGCTGGTTTGTGCTCAAGGGGGATCAGCTCTATTATTTCAAAGATGAAGATGAAACCAAGCCCTTGATTCTTTCTTGTGGAGAA
GTTATTCATGTGAAGATCCTTGGAATTTTGGCTCTTATTGATGAAGGTGAAACAGATTGGAAATTAATTGCTATCAATGCGAATGATCCT
GAAGCCTCAAAGTTTCATGATATTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAG
GTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCAT
CAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGC
ACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTT
GGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATT
TACTGACTTCCTGTTAAAACTTCATTTTTTCAAACTTTTTGAGCTATGCAATATATAAATAAACAGTAAGAATTTTAAATTACTCTCCTT
TGGACATTTATTGATATAAAAAGAAGATTTTGGCCAGGCACGGTGGCTCATGCCTGTAATTTCAGCACTTTGGGAGGCCGAGGTGGGCAG
ATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAGTATGTTGAAACCCCATCTCTATTAAAAATACAAAAATTAGCCAGGCGTGGTGGT
GCATGCCTGTAGACCCAGCTACTCAGGAGGCTGAGGCAGAAGAACTGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCAGAGATTGTGC

>In-frame_ENST00000503995_ENST00000348706_135N_ARHGAP24_chr4_86491874_+_PPA2_chr4_106345479_length(amino acids)=280AA_start in transcript=156_stop in transcript=998
MRSSPVHRVQHFPLLWKVKEPHYHLFFFAFSYCWSWEPFPSEQQPCPASVLSSQQGKSISLIMEENNDSTENPQQGQGRQNAIKCGWLRK
QGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEAT
LNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNE

--------------------------------------------------------------
>In-frame_ENST00000503995_ENST00000432483_135N_ARHGAP24_chr4_86491874_+_PPA2_chr4_106345479_length(transcript)=1159nt_BP=522nt
GGGCTCTGGAGGGGCTCGGAGACCAGGGGAGCTGTCAAGGCTGCGGCGGGGACCAGAGAGGAGCCTGGCGGGGGTGGCTGGGTGGCTGGG
GGAATCCCCCCAACTTCCCATCGCAGGCGCAGCTCTCTCGGCCGCCTATTTCCTCCGAAACCCGCGCTGCGGAGCAGCCCAGTGCATAGA
GTTCAACACTTCCCCTTGTTGTGGAAAGTAAAGGAGCCTCACTACCACCTTTTTTTCTTTGCGTTTTCTTACTGCTGGTCCTGGGAGCCT
TTTCCTTCGGAGCAGCAGCCCTGTCCGGCATCTGTCTTGAGCTCCCAGCAAGGAAAGTCCATCAGCTTGATAATGGAGGAGAACAATGAC
TCCACGGAGAACCCCCAACAAGGCCAAGGGCGGCAGAATGCCATCAAGTGTGGGTGGCTGAGGAAGCAAGGAGGCTTTGTCAAGACTTGG
CATACTCGCTGGTTTGTGCTCAAGGGGGATCAGCTCTATTATTTCAAAGATGAAGATGAAACCAAGCCCTTGATTCTTTCTTGTGGAGAA
GTTATTCATGTGAAGATCCTTGGAATTTTGGCTCTTATTGATGAAGGTGAAACAGATTGGAAATTAATTGCTATCAATGCGAATGATCCT
GAAGCCTCAAAGTTTCATGATATTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAG
GTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCAT
CAATGTTGGAAAGCATTGCTTATGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGC
ACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTT
GGCAAGTGATTGAAACATCTGAAATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATT

>In-frame_ENST00000503995_ENST00000432483_135N_ARHGAP24_chr4_86491874_+_PPA2_chr4_106345479_length(amino acids)=280AA_start in transcript=156_stop in transcript=998
MRSSPVHRVQHFPLLWKVKEPHYHLFFFAFSYCWSWEPFPSEQQPCPASVLSSQQGKSISLIMEENNDSTENPQQGQGRQNAIKCGWLRK
QGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEAT
LNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP24-PPA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP24-PPA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP24-PPA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP24C0017668Focal glomerulosclerosis1GENOMICS_ENGLAND
HgeneARHGAP24C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
HgeneARHGAP24C4049702Focal Segmental Glomerulosclerosis, Not Otherwise Specified1GENOMICS_ENGLAND
TgenePPA2C4310663SUDDEN CARDIAC FAILURE, ALCOHOL-INDUCED2CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePPA2C4310664SUDDEN CARDIAC FAILURE, INFANTILE2CTD_human;GENOMICS_ENGLAND;UNIPROT