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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OSBPL5-TRPM5 (FusionGDB2 ID:61445)

Fusion Gene Summary for OSBPL5-TRPM5

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL5-TRPM5
Fusion gene ID: 61445
HgeneTgene
Gene symbol

OSBPL5

TRPM5

Gene ID

114879

29850

Gene nameoxysterol binding protein like 5transient receptor potential cation channel subfamily M member 5
SynonymsOBPH1|ORP5LTRPC5|MTR1
Cytomap

11p15.4

11p15.5

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 5ORP-5OSBP-related protein 5oxysterol-binding protein homolog 1oxysterol-binding protein homologue 1transient receptor potential cation channel subfamily M member 5LTrpC-5MLSN1 and TRP-relatedMLSN1- and TRP-related gene 1 proteinlong transient receptor potential channel 5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263650, ENST00000389989, 
ENST00000525498, ENST00000542243, 
ENST00000348039, ENST00000478260, 
ENST00000528124, 		ENST00000155858, 
ENST00000452833, ENST00000533060, 
ENST00000528453, 
Fusion gene scores* DoF score11 X 8 X 6=5282 X 2 X 2=8
# samples 122
** MAII scorelog2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: OSBPL5 [Title/Abstract] AND TRPM5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOSBPL5(3125423)-TRPM5(2427321), # samples:2
Anticipated loss of major functional domain due to fusion event.OSBPL5-TRPM5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
OSBPL5-TRPM5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOSBPL5

GO:0015914

phospholipid transport

26206935


check buttonFusion gene breakpoints across OSBPL5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TRPM5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J4-01AOSBPL5chr11

3125423

-TRPM5chr11

2427321

-
ChimerDB4STADTCGA-BR-A4J4-01AOSBPL5chr11

3125423

-TRPM5chr11

2427321

-


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Fusion Gene ORF analysis for OSBPL5-TRPM5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000263650ENST00000155858OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000263650ENST00000452833OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000263650ENST00000533060OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000263650ENST00000528453OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000389989ENST00000155858OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000389989ENST00000452833OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000389989ENST00000533060OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000389989ENST00000528453OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
In-frameENST00000525498ENST00000155858OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
In-frameENST00000525498ENST00000452833OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
In-frameENST00000525498ENST00000533060OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
In-frameENST00000525498ENST00000528453OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000542243ENST00000155858OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000542243ENST00000452833OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000542243ENST00000533060OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000542243ENST00000528453OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000348039ENST00000155858OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000348039ENST00000452833OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000348039ENST00000533060OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
Frame-shiftENST00000348039ENST00000528453OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
intron-3CDSENST00000478260ENST00000155858OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
intron-3CDSENST00000478260ENST00000452833OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
intron-3CDSENST00000478260ENST00000533060OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
intron-3CDSENST00000478260ENST00000528453OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
intron-3CDSENST00000528124ENST00000155858OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
intron-3CDSENST00000528124ENST00000452833OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
intron-3CDSENST00000528124ENST00000533060OSBPL5chr11

3125423

-TRPM5chr11

2427321

-
intron-3CDSENST00000528124ENST00000528453OSBPL5chr11

3125423

-TRPM5chr11

2427321

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000525498OSBPL5chr113125423-ENST00000155858TRPM5chr112427321-1707103841284426
ENST00000525498OSBPL5chr113125423-ENST00000452833TRPM5chr112427321-1704103841284426
ENST00000525498OSBPL5chr113125423-ENST00000533060TRPM5chr112427321-1319103841080358
ENST00000525498OSBPL5chr113125423-ENST00000528453TRPM5chr112427321-1316103841287427

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000525498ENST00000155858OSBPL5chr113125423-TRPM5chr112427321-0.0309060890.9690939
ENST00000525498ENST00000452833OSBPL5chr113125423-TRPM5chr112427321-0.0307941870.9692058
ENST00000525498ENST00000533060OSBPL5chr113125423-TRPM5chr112427321-0.0511020870.94889796
ENST00000525498ENST00000528453OSBPL5chr113125423-TRPM5chr112427321-0.038117270.9618827

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Fusion Genomic Features for OSBPL5-TRPM5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for OSBPL5-TRPM5


check button Go to

FGviewer for the breakpoints of chr11:3125423-chr11:2427321

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000263650-102293_123414.6666666666667880.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000348039-92193_123346.6666666666667812.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000389989-92193_123346.6666666666667812.0Coiled coilOntology_term=ECO:0000255
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000263650-1022126_243414.6666666666667880.0DomainPH
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000348039-921126_243346.6666666666667812.0DomainPH
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000389989-921126_243346.6666666666667812.0DomainPH
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000263650-1022384_389414.6666666666667880.0RegionPhosphatidylserine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000263650-1022446_449414.6666666666667880.0RegionPhosphatidylinositol 4-phosphate binding
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000348039-921384_389346.6666666666667812.0RegionPhosphatidylserine binding
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000348039-921446_449346.6666666666667812.0RegionPhosphatidylinositol 4-phosphate binding
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000389989-921384_389346.6666666666667812.0RegionPhosphatidylserine binding
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000389989-921446_449346.6666666666667812.0RegionPhosphatidylinositol 4-phosphate binding
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000263650-1022860_878414.6666666666667880.0TransmembraneHelical
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000348039-921860_878346.6666666666667812.0TransmembraneHelical
HgeneOSBPL5chr11:3125423chr11:2427321ENST00000389989-921860_878346.6666666666667812.0TransmembraneHelical
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024553_5811083.66666666666671166.0Coiled coilOntology_term=ECO:0000255
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024553_5811085.66666666666671168.0Coiled coilOntology_term=ECO:0000255
TgeneTRPM5chr11:3125423chr11:2427321ENST0000015585820241_6461083.66666666666671166.0Topological domainCytoplasmic
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024668_7331083.66666666666671166.0Topological domainExtracellular
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024755_8111083.66666666666671166.0Topological domainCytoplasmic
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024833_8351083.66666666666671166.0Topological domainExtracellular
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024857_8721083.66666666666671166.0Topological domainCytoplasmic
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024894_9541083.66666666666671166.0Topological domainExtracellular
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024976_11651083.66666666666671166.0Topological domainCytoplasmic
TgeneTRPM5chr11:3125423chr11:2427321ENST0000045283320241_6461085.66666666666671168.0Topological domainCytoplasmic
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024668_7331085.66666666666671168.0Topological domainExtracellular
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024755_8111085.66666666666671168.0Topological domainCytoplasmic
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024833_8351085.66666666666671168.0Topological domainExtracellular
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024857_8721085.66666666666671168.0Topological domainCytoplasmic
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024894_9541085.66666666666671168.0Topological domainExtracellular
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024976_11651085.66666666666671168.0Topological domainCytoplasmic
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024647_6671083.66666666666671166.0TransmembraneHelical
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024734_7541083.66666666666671166.0TransmembraneHelical
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024812_8321083.66666666666671166.0TransmembraneHelical
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024836_8561083.66666666666671166.0TransmembraneHelical
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024873_8931083.66666666666671166.0TransmembraneHelical
TgeneTRPM5chr11:3125423chr11:2427321ENST000001558582024955_9751083.66666666666671166.0TransmembraneHelical
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024647_6671085.66666666666671168.0TransmembraneHelical
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024734_7541085.66666666666671168.0TransmembraneHelical
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024812_8321085.66666666666671168.0TransmembraneHelical
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024836_8561085.66666666666671168.0TransmembraneHelical
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024873_8931085.66666666666671168.0TransmembraneHelical
TgeneTRPM5chr11:3125423chr11:2427321ENST000004528332024955_9751085.66666666666671168.0TransmembraneHelical


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Fusion Gene Sequence for OSBPL5-TRPM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000525498_ENST00000155858_TCGA-BR-A4J4-01A_OSBPL5_chr11_3125423_-_TRPM5_chr11_2427321_length(transcript)=1707nt_BP=1038nt
AAGCCTGGCCACGCCACCATGCCTGGGTCCTCACTCCCACTGCTCTCTTGCAGGGAAGGACATGGAGCCCAACGGCCCGTCGCTGCCCAG
GGATGAAGGGCCCCCGACCCCAAGCTCTGCCACGAAGGTGCCACCGGCAGAGTACAGGCTGTGCAACGGGTCAGACAAGGAATGTGTGTC
CCCCACCGCCAGGGTCACCAAGAAGGAGACTCTCAAGGCGCAGAAGGAGAACTACCGGCAGGAGAAGAAGCGCGCCACACGGCAGCTGCT
CAGCGCTCTGACAGACCCCAGCGTGGTCATCATGGCTGACAGCCTGAAGATCCGCGGCACCCTGAAGAGCTGGACCAAGCTGTGGTGCGT
GCTGAAGCCGGGGGTGCTGCTCATCTACAAGACGCCCAAGGGCCCCAAAGGTGAGAGCGTGGGCTCCATCACACAGCCCCTGCCCAGCAG
CTACCTGATCTTCAGGGCCGCCTCCGAGTCAGATGGTCGCTGCTGGCTGGACGCCCTGGAGCTGGCCCTGCGCTGCTCTAGCCTACTGAG
ACTGGGCACCTGCAAGCCGGGCCGAGACGGGGAGCCAGGGACCTCGCCAGACGCATCACCCTCATCGCTCTGTGGGCTGCCAGCCTCAGC
CACCGTCCACCCAGACCAAGACCTGTTCCCACTGAACGGGTCTTCCCTGGAGAACGATGCATTCTCAGACAAGTCGGAGAGAGAGAACCC
TGAGGAGTCAGATACCGAGACCCAGGACCATAGCCGGAAGACGGAGAGTGGCAGCGACCAGTCAGAGACCCCTGGGGCCCCGGTGCGGAG
AGGGACCACCTATGTGGAGCAGGTCCAGGAGGAGCTGGGGGAGCTGGGCGAGGCGTCCCAGGTGGAGACAGTGTCAGAGGAGAACAAGAG
TCTGATGTGGACCCTGCTGAAGCAGCTACGGCCAGGCATGGACCTGTCCCGCGTGGTGCTACCCACGTTCGTACTGGAGCCGCGCTCCTT
CCTGAACAAGCTCTCCGACTACTACTACCACGCAGACCTGCTCTCCAGAGTGGACTTCATTGCCAAGTACCTCGGGGGTCTGAGAGAGCA
AGAAAAGCGCATCAAGTGTCTGGAGTCACAGATCAACTACTGCTCGGTGCTCGTGTCCTCCGTGGCTGACGTGCTGGCCCAGGGTGGCGG
CCCCCGGAGCTCTCAGCACTGTGGCGAGGGAAGCCAGCTGGTGGCTGCTGACCACAGAGGTGGTTTAGATGGCTGGGAACAACCCGGGGC
TGGCCAGCCTCCCTCGGACACCTGAGCTGCTTGGCCTGCCACGTGTGGGGCCACCTCTCCTCAGCTGGCCACCCTGCACGTTGTGCACTG
ACCTTTGCCGACCTCCAGCGGAACCCCCCAGGGGGCACCAGCCCCCCAGCAGACAATGGCCCTCCTGGTGCCTCACCACAGACCCTCACC
CAAAGGAACCGCTCCTTGTCCCTCCTGGCCTCCCCGGAGGCACAGCAGTGTCATGGGGCTGTCTCCCCTGACAGGCACAACTCCCCGGGC
AGAAAACGTGCCCCACCGCATCCCTACCTGGAAACTGACCAGCCTGCACTGTGGAAAAGCTGGCCCTGTGGCGTGACGGGGGAGCACCCC

>In-frame_ENST00000525498_ENST00000155858_TCGA-BR-A4J4-01A_OSBPL5_chr11_3125423_-_TRPM5_chr11_2427321_length(amino acids)=426AA_start in transcript=4_stop in transcript=1284
MATPPCLGPHSHCSLAGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLS
ALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLLRL
GTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSERENPEESDTETQDHSRKTESGSDQSETPGAPVRRG
TTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRVDFIAKYLGGLREQE

--------------------------------------------------------------
>In-frame_ENST00000525498_ENST00000452833_TCGA-BR-A4J4-01A_OSBPL5_chr11_3125423_-_TRPM5_chr11_2427321_length(transcript)=1704nt_BP=1038nt
AAGCCTGGCCACGCCACCATGCCTGGGTCCTCACTCCCACTGCTCTCTTGCAGGGAAGGACATGGAGCCCAACGGCCCGTCGCTGCCCAG
GGATGAAGGGCCCCCGACCCCAAGCTCTGCCACGAAGGTGCCACCGGCAGAGTACAGGCTGTGCAACGGGTCAGACAAGGAATGTGTGTC
CCCCACCGCCAGGGTCACCAAGAAGGAGACTCTCAAGGCGCAGAAGGAGAACTACCGGCAGGAGAAGAAGCGCGCCACACGGCAGCTGCT
CAGCGCTCTGACAGACCCCAGCGTGGTCATCATGGCTGACAGCCTGAAGATCCGCGGCACCCTGAAGAGCTGGACCAAGCTGTGGTGCGT
GCTGAAGCCGGGGGTGCTGCTCATCTACAAGACGCCCAAGGGCCCCAAAGGTGAGAGCGTGGGCTCCATCACACAGCCCCTGCCCAGCAG
CTACCTGATCTTCAGGGCCGCCTCCGAGTCAGATGGTCGCTGCTGGCTGGACGCCCTGGAGCTGGCCCTGCGCTGCTCTAGCCTACTGAG
ACTGGGCACCTGCAAGCCGGGCCGAGACGGGGAGCCAGGGACCTCGCCAGACGCATCACCCTCATCGCTCTGTGGGCTGCCAGCCTCAGC
CACCGTCCACCCAGACCAAGACCTGTTCCCACTGAACGGGTCTTCCCTGGAGAACGATGCATTCTCAGACAAGTCGGAGAGAGAGAACCC
TGAGGAGTCAGATACCGAGACCCAGGACCATAGCCGGAAGACGGAGAGTGGCAGCGACCAGTCAGAGACCCCTGGGGCCCCGGTGCGGAG
AGGGACCACCTATGTGGAGCAGGTCCAGGAGGAGCTGGGGGAGCTGGGCGAGGCGTCCCAGGTGGAGACAGTGTCAGAGGAGAACAAGAG
TCTGATGTGGACCCTGCTGAAGCAGCTACGGCCAGGCATGGACCTGTCCCGCGTGGTGCTACCCACGTTCGTACTGGAGCCGCGCTCCTT
CCTGAACAAGCTCTCCGACTACTACTACCACGCAGACCTGCTCTCCAGAGTGGACTTCATTGCCAAGTACCTCGGGGGTCTGAGAGAGCA
AGAAAAGCGCATCAAGTGTCTGGAGTCACAGATCAACTACTGCTCGGTGCTCGTGTCCTCCGTGGCTGACGTGCTGGCCCAGGGTGGCGG
CCCCCGGAGCTCTCAGCACTGTGGCGAGGGAAGCCAGCTGGTGGCTGCTGACCACAGAGGTGGTTTAGATGGCTGGGAACAACCCGGGGC
TGGCCAGCCTCCCTCGGACACCTGAGCTGCTTGGCCTGCCACGTGTGGGGCCACCTCTCCTCAGCTGGCCACCCTGCACGTTGTGCACTG
ACCTTTGCCGACCTCCAGCGGAACCCCCCAGGGGGCACCAGCCCCCCAGCAGACAATGGCCCTCCTGGTGCCTCACCACAGACCCTCACC
CAAAGGAACCGCTCCTTGTCCCTCCTGGCCTCCCCGGAGGCACAGCAGTGTCATGGGGCTGTCTCCCCTGACAGGCACAACTCCCCGGGC
AGAAAACGTGCCCCACCGCATCCCTACCTGGAAACTGACCAGCCTGCACTGTGGAAAAGCTGGCCCTGTGGCGTGACGGGGGAGCACCCC

>In-frame_ENST00000525498_ENST00000452833_TCGA-BR-A4J4-01A_OSBPL5_chr11_3125423_-_TRPM5_chr11_2427321_length(amino acids)=426AA_start in transcript=4_stop in transcript=1284
MATPPCLGPHSHCSLAGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLS
ALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLLRL
GTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSERENPEESDTETQDHSRKTESGSDQSETPGAPVRRG
TTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRVDFIAKYLGGLREQE

--------------------------------------------------------------
>In-frame_ENST00000525498_ENST00000533060_TCGA-BR-A4J4-01A_OSBPL5_chr11_3125423_-_TRPM5_chr11_2427321_length(transcript)=1319nt_BP=1038nt
AAGCCTGGCCACGCCACCATGCCTGGGTCCTCACTCCCACTGCTCTCTTGCAGGGAAGGACATGGAGCCCAACGGCCCGTCGCTGCCCAG
GGATGAAGGGCCCCCGACCCCAAGCTCTGCCACGAAGGTGCCACCGGCAGAGTACAGGCTGTGCAACGGGTCAGACAAGGAATGTGTGTC
CCCCACCGCCAGGGTCACCAAGAAGGAGACTCTCAAGGCGCAGAAGGAGAACTACCGGCAGGAGAAGAAGCGCGCCACACGGCAGCTGCT
CAGCGCTCTGACAGACCCCAGCGTGGTCATCATGGCTGACAGCCTGAAGATCCGCGGCACCCTGAAGAGCTGGACCAAGCTGTGGTGCGT
GCTGAAGCCGGGGGTGCTGCTCATCTACAAGACGCCCAAGGGCCCCAAAGGTGAGAGCGTGGGCTCCATCACACAGCCCCTGCCCAGCAG
CTACCTGATCTTCAGGGCCGCCTCCGAGTCAGATGGTCGCTGCTGGCTGGACGCCCTGGAGCTGGCCCTGCGCTGCTCTAGCCTACTGAG
ACTGGGCACCTGCAAGCCGGGCCGAGACGGGGAGCCAGGGACCTCGCCAGACGCATCACCCTCATCGCTCTGTGGGCTGCCAGCCTCAGC
CACCGTCCACCCAGACCAAGACCTGTTCCCACTGAACGGGTCTTCCCTGGAGAACGATGCATTCTCAGACAAGTCGGAGAGAGAGAACCC
TGAGGAGTCAGATACCGAGACCCAGGACCATAGCCGGAAGACGGAGAGTGGCAGCGACCAGTCAGAGACCCCTGGGGCCCCGGTGCGGAG
AGGGACCACCTATGTGGAGCAGGTCCAGGAGGAGCTGGGGGAGCTGGGCGAGGCGTCCCAGGTGGAGACAGTGTCAGAGGAGAACAAGAG
TCTGATGTGGACCCTGCTGAAGCAGCTACGGCCAGGCATGGACCTGTCCCGCGTGGTGCTACCCACGTTCGTACTGGAGCCGCGCTCCTT
CCTGAACAAGCTCTCCGACTACTACTACCACGCAGACCTGCTCTCCAGGCTCTCAGCACTGTGGCGAGGGAAGCCAGCTGGTGGCTGCTG
ACCACAGAGGTGGTTTAGATGGCTGGGAACAACCCGGGGCTGGCCAGCCTCCCTCGGACACCTGAGCTGCTTGGCCTGCCACGTGTGGGG
CCACCTCTCATCAACTACTGCTCGGTGCTCGTGTCCTCCGTGGCTGACGTGCTGGCCCAGGGTGGCGGCCCCCGGAAGTGGACTTCATTG

>In-frame_ENST00000525498_ENST00000533060_TCGA-BR-A4J4-01A_OSBPL5_chr11_3125423_-_TRPM5_chr11_2427321_length(amino acids)=358AA_start in transcript=4_stop in transcript=1080
MATPPCLGPHSHCSLAGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLS
ALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLLRL
GTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSERENPEESDTETQDHSRKTESGSDQSETPGAPVRRG

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>In-frame_ENST00000525498_ENST00000528453_TCGA-BR-A4J4-01A_OSBPL5_chr11_3125423_-_TRPM5_chr11_2427321_length(transcript)=1316nt_BP=1038nt
AAGCCTGGCCACGCCACCATGCCTGGGTCCTCACTCCCACTGCTCTCTTGCAGGGAAGGACATGGAGCCCAACGGCCCGTCGCTGCCCAG
GGATGAAGGGCCCCCGACCCCAAGCTCTGCCACGAAGGTGCCACCGGCAGAGTACAGGCTGTGCAACGGGTCAGACAAGGAATGTGTGTC
CCCCACCGCCAGGGTCACCAAGAAGGAGACTCTCAAGGCGCAGAAGGAGAACTACCGGCAGGAGAAGAAGCGCGCCACACGGCAGCTGCT
CAGCGCTCTGACAGACCCCAGCGTGGTCATCATGGCTGACAGCCTGAAGATCCGCGGCACCCTGAAGAGCTGGACCAAGCTGTGGTGCGT
GCTGAAGCCGGGGGTGCTGCTCATCTACAAGACGCCCAAGGGCCCCAAAGGTGAGAGCGTGGGCTCCATCACACAGCCCCTGCCCAGCAG
CTACCTGATCTTCAGGGCCGCCTCCGAGTCAGATGGTCGCTGCTGGCTGGACGCCCTGGAGCTGGCCCTGCGCTGCTCTAGCCTACTGAG
ACTGGGCACCTGCAAGCCGGGCCGAGACGGGGAGCCAGGGACCTCGCCAGACGCATCACCCTCATCGCTCTGTGGGCTGCCAGCCTCAGC
CACCGTCCACCCAGACCAAGACCTGTTCCCACTGAACGGGTCTTCCCTGGAGAACGATGCATTCTCAGACAAGTCGGAGAGAGAGAACCC
TGAGGAGTCAGATACCGAGACCCAGGACCATAGCCGGAAGACGGAGAGTGGCAGCGACCAGTCAGAGACCCCTGGGGCCCCGGTGCGGAG
AGGGACCACCTATGTGGAGCAGGTCCAGGAGGAGCTGGGGGAGCTGGGCGAGGCGTCCCAGGTGGAGACAGTGTCAGAGGAGAACAAGAG
TCTGATGTGGACCCTGCTGAAGCAGCTACGGCCAGGCATGGACCTGTCCCGCGTGGTGCTACCCACGTTCGTACTGGAGCCGCGCTCCTT
CCTGAACAAGCTCTCCGACTACTACTACCACGCAGACCTGCTCTCCAGAGTGGACTTCATTGCCAAGTACCTCGGGGGTCTGAGAGAGCA
AGAAAAGCGCATCAAGTGTCTGGAGTCACAGATCAACTACTGCTCGGTGCTCGTGTCCTCCGTGGCTGACGTGCTGGCCCAGGGTGGCGG
CCCCCGGACAGGCTCTCAGCACTGTGGCGAGGGAAGCCAGCTGGTGGCTGCTGACCACAGAGGTGGTTTAGATGGCTGGGAACAACCCGG

>In-frame_ENST00000525498_ENST00000528453_TCGA-BR-A4J4-01A_OSBPL5_chr11_3125423_-_TRPM5_chr11_2427321_length(amino acids)=427AA_start in transcript=4_stop in transcript=1287
MATPPCLGPHSHCSLAGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLS
ALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLLRL
GTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSERENPEESDTETQDHSRKTESGSDQSETPGAPVRRG
TTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRVDFIAKYLGGLREQE

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Fusion Gene PPI Analysis for OSBPL5-TRPM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OSBPL5-TRPM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OSBPL5-TRPM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOSBPL5C0001973Alcoholic Intoxication, Chronic1PSYGENET