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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:OSBPL8-NTS (FusionGDB2 ID:61460)

Fusion Gene Summary for OSBPL8-NTS

Fusion gene summary

Fusion gene information	Fusion gene name: OSBPL8-NTS
	Fusion gene ID: 61460
		Hgene	Tgene
	Gene symbol	OSBPL8	NTS
	Gene ID	114882	4922
	Gene name	oxysterol binding protein like 8	neurotensin
	Synonyms	MST120\|MSTP120\|ORP8\|OSBP10	NMN-125\|NN\|NT\|NT/N\|NTS1
	Cytomap	12q21.2	12q21.31
	Type of gene	protein-coding	protein-coding
	Description	oxysterol-binding protein-related protein 8OSBP-related protein 8	neurotensin/neuromedin Npro-neurotensin/neuromedin
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000393249, ENST00000261183, ENST00000393250, ENST00000552178,	ENST00000551529, ENST00000256010,
Fusion gene scores	* DoF score	20 X 9 X 5=900	3 X 3 X 2=18
	# samples	18	3
	** MAII score	log2(18/900*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: OSBPL8 [Title/Abstract] AND NTS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	OSBPL8(76844631)-NTS(86270418), # samples:1
Anticipated loss of major functional domain due to fusion event.	OSBPL8-NTS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	OSBPL8	GO:0010891	negative regulation of sequestering of triglyceride	23028956
Hgene	OSBPL8	GO:0015914	phospholipid transport	26206935
Hgene	OSBPL8	GO:0045444	fat cell differentiation	23028956

Fusion gene breakpoints across OSBPL8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NTS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-3B-A9HL-01A	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+

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Fusion Gene ORF analysis for OSBPL8-NTS

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000393249	ENST00000551529	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+
In-frame	ENST00000393249	ENST00000256010	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+
In-frame	ENST00000261183	ENST00000551529	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+
In-frame	ENST00000261183	ENST00000256010	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+
Frame-shift	ENST00000393250	ENST00000551529	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+
Frame-shift	ENST00000393250	ENST00000256010	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+
intron-3CDS	ENST00000552178	ENST00000551529	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+
intron-3CDS	ENST00000552178	ENST00000256010	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393249	OSBPL8	chr12	76844631	-	ENST00000551529	NTS	chr12	86270418	+	1121	502	396	716	106
ENST00000393249	OSBPL8	chr12	76844631	-	ENST00000256010	NTS	chr12	86270418	+	1559	502	396	941	181
ENST00000261183	OSBPL8	chr12	76844631	-	ENST00000551529	NTS	chr12	86270418	+	1316	697	282	911	209
ENST00000261183	OSBPL8	chr12	76844631	-	ENST00000256010	NTS	chr12	86270418	+	1754	697	282	1136	284

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393249	ENST00000551529	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+	0.025247168	0.97475284
ENST00000393249	ENST00000256010	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+	0.00156196	0.99843806
ENST00000261183	ENST00000551529	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+	0.004673668	0.9953263
ENST00000261183	ENST00000256010	OSBPL8	chr12	76844631	-	NTS	chr12	86270418	+	0.001721602	0.9982784

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Fusion Genomic Features for OSBPL8-NTS

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
OSBPL8	chr12	76844630	-	NTS	chr12	86270417	+	5.89E-06	0.99999416
OSBPL8	chr12	76844630	-	NTS	chr12	86270417	+	5.89E-06	0.99999416

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for OSBPL8-NTS

Go to
FGviewer for the breakpoints of chr12:76844631-chr12:86270418
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

OSBPL8

chr12:76844631

chr12:86270418

ENST00000261183

148_265

72.33333333333333

890.0

Domain

Hgene

OSBPL8

chr12:76844631

chr12:86270418

ENST00000393249

148_265

30.333333333333332

848.0

Domain

Hgene

OSBPL8

chr12:76844631

chr12:86270418

ENST00000393250

148_265

30.333333333333332

848.0

Domain

Hgene

OSBPL8

chr12:76844631

chr12:86270418

ENST00000261183

420_425

72.33333333333333

890.0

Region

Phosphatidylserine binding

Hgene

OSBPL8

chr12:76844631

chr12:86270418

ENST00000261183

482_485

72.33333333333333

890.0

Region

Phosphatidylinositol 4-phosphate binding

Hgene

OSBPL8

chr12:76844631

chr12:86270418

ENST00000393249

420_425

30.333333333333332

848.0

Region

Phosphatidylserine binding

Hgene

OSBPL8

chr12:76844631

chr12:86270418

ENST00000393249

482_485

30.333333333333332

848.0

Region

Phosphatidylinositol 4-phosphate binding

Hgene

OSBPL8

chr12:76844631

chr12:86270418

ENST00000393250

420_425

30.333333333333332

848.0

Region

Phosphatidylserine binding

Hgene

OSBPL8

chr12:76844631

chr12:86270418

ENST00000393250

482_485

30.333333333333332

848.0

Region

Phosphatidylinositol 4-phosphate binding

Hgene

OSBPL8

chr12:76844631

chr12:86270418

ENST00000261183

871_888

72.33333333333333

890.0

Transmembrane

Helical

Hgene

OSBPL8

chr12:76844631

chr12:86270418

ENST00000393249

871_888

30.333333333333332

848.0

Transmembrane

Helical

Hgene

OSBPL8

chr12:76844631

chr12:86270418

ENST00000393250

871_888

30.333333333333332

848.0

Transmembrane

Helical

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Fusion Gene Sequence for OSBPL8-NTS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000393249_ENST00000551529_TCGA-3B-A9HL-01A_OSBPL8_chr12_76844631_-_NTS_chr12_86270418_length(transcript)=1121nt_BP=502nt
CGCCCCAGCTGCCGCCGACGACAGCGGCCGAGAGAAGTTGGGGTCTGACTAGACGCTTACGGGGCCTCGGACCCCGGCGCCGCGGCGACC
TCGGAGGAACCGGCTCCTTGCGTCCCGCCTCCCTGGGAGCTCCGCACGGCAATCTCCATTGGTGCTACTGCGTTTAAAGAACTGTGGCTA
ACCTCCAAGAGACTGAAGCTGGTAATTAAACATTCCTATCCTTGCCTGAAGCAGTCTTTTGCAGGAACATTTGAGGATTTGCAGATTTAC
AGAATGGCTGCACATTAATGGAAAGAGAAGCATAAACCTATCTTCTTTCATTATGGAGGGAGGTTTGGCAGATGGAGAACCTGATCGAAC
TTCGCTGTTGTAGCAAACAGTGACGAATCTCAGCTTCTGACACCAGGAAAGATGAGTCAGCGCCAAGGAAAAGAAGCTTATCCAACGCCA
ACCAAAGATTTGCATCAGCCATCTCTTAGTCCAGCAAGTCCTCATAGCCAGGATTCAGAAGAGGAAATGAAAGCATTAGAAGCAGATTTC
TTGACCAATATGCATACATCAAAGTTAATCCAGGAAGATATTCTTGATACTGGAAATGACAAAAATGGAAAGGAAGAAGTCATAAAGAGA
AAAATTCCTTATATTCTGAAACGGCAGCTGTATGAGAATAAACCCAGAAGACCCTACATACTCAAAAGAGATTCTTACTATTACTGAGAG
AATAAATCATTTATTTACATGTGATTGTGATTCATCATCCCTTAATTAAATATCAAATTATATTTGTGTGAAAATGTGACAAACACACTT
ATCTGTCTCTTCTACAATTGTGGTTTATTGAATGTGATTTTTCTGCACTAATATAAATTAGACTAAGTGTTTTCAAATAAATCTAAATCT
TCAGCATGATGTGTTGTGTATAATTGGAGTAGATATTAATTAAGTCACCTGTATAATGTTTTGTAATTTTGCAAAACATATCTTGAGTTG
TTTAAACAGTCAAAATGTTTGATATTTTATACCAGCTTATGAGCTCAAAGTACTACAGCAAAGCCTAGCCTGCATATCATTCACCCAAAA

>In-frame_ENST00000393249_ENST00000551529_TCGA-3B-A9HL-01A_OSBPL8_chr12_76844631_-_NTS_chr12_86270418_length(amino acids)=106AA_start in transcript=396_stop in transcript=716
MTPGKMSQRQGKEAYPTPTKDLHQPSLSPASPHSQDSEEEMKALEADFLTNMHTSKLIQEDILDTGNDKNGKEEVIKRKIPYILKRQLYE

--------------------------------------------------------------
>In-frame_ENST00000393249_ENST00000256010_TCGA-3B-A9HL-01A_OSBPL8_chr12_76844631_-_NTS_chr12_86270418_length(transcript)=1559nt_BP=502nt
CGCCCCAGCTGCCGCCGACGACAGCGGCCGAGAGAAGTTGGGGTCTGACTAGACGCTTACGGGGCCTCGGACCCCGGCGCCGCGGCGACC
TCGGAGGAACCGGCTCCTTGCGTCCCGCCTCCCTGGGAGCTCCGCACGGCAATCTCCATTGGTGCTACTGCGTTTAAAGAACTGTGGCTA
ACCTCCAAGAGACTGAAGCTGGTAATTAAACATTCCTATCCTTGCCTGAAGCAGTCTTTTGCAGGAACATTTGAGGATTTGCAGATTTAC
AGAATGGCTGCACATTAATGGAAAGAGAAGCATAAACCTATCTTCTTTCATTATGGAGGGAGGTTTGGCAGATGGAGAACCTGATCGAAC
TTCGCTGTTGTAGCAAACAGTGACGAATCTCAGCTTCTGACACCAGGAAAGATGAGTCAGCGCCAAGGAAAAGAAGCTTATCCAACGCCA
ACCAAAGATTTGCATCAGCCATCTCTTAGTCCAGCAAGTCCTCATAGCCAGGATTCAGAAGAGGAAATGAAAGCATTAGAAGCAGATTTC
TTGACCAATATGCATACATCAAAGATTAGTAAAGCACATGTTCCCTCTTGGAAGATGACTCTGCTAAATGTTTGCAGTCTTGTAAATAAT
TTGAACAGCCCAGCTGAGGAAACAGGAGAAGTTCATGAAGAGGAGCTTGTTGCAAGAAGGAAACTTCCTACTGCTTTAGATGGCTTTAGC
TTGGAAGCAATGTTGACAATATACCAGCTCCACAAAATCTGTCACAGCAGGGCTTTTCAACACTGGGAGTTAATCCAGGAAGATATTCTT
GATACTGGAAATGACAAAAATGGAAAGGAAGAAGTCATAAAGAGAAAAATTCCTTATATTCTGAAACGGCAGCTGTATGAGAATAAACCC
AGAAGACCCTACATACTCAAAAGAGATTCTTACTATTACTGAGAGAATAAATCATTTATTTACATGTGATTGTGATTCATCATCCCTTAA
TTAAATATCAAATTATATTTGTGTGAAAATGTGACAAACACACTTATCTGTCTCTTCTACAATTGTGGTTTATTGAATGTGATTTTTCTG
CACTAATATAAATTAGACTAAGTGTTTTCAAATAAATCTAAATCTTCAGCATGATGTGTTGTGTATAATTGGAGTAGATATTAATTAAGT
CACCTGTATAATGTTTTGTAATTTTGCAAAACATATCTTGAGTTGTTTAAACAGTCAAAATGTTTGATATTTTATACCAGCTTATGAGCT
CAAAGTACTACAGCAAAGCCTAGCCTGCATATCATTCACCCAAAACAAAGTAATAGCGCCTCTTTTATTATTTTGACTGAATGTTTTATG
GAATTGAAAGAAACATACGTTCTTTTCAAGACTTCCTCATGAATCTCTCAATTATAGGAAAAGTTATTGTGATAAAATAGGAACAGCTGA
AAGATTGATTAATGAACTATTGTTAATTCTTCCTATTTTAATGAATGACATTGAACTGAATTTTTTGTCTGTTAAATGAACTTGATAGCT

>In-frame_ENST00000393249_ENST00000256010_TCGA-3B-A9HL-01A_OSBPL8_chr12_76844631_-_NTS_chr12_86270418_length(amino acids)=181AA_start in transcript=396_stop in transcript=941
MTPGKMSQRQGKEAYPTPTKDLHQPSLSPASPHSQDSEEEMKALEADFLTNMHTSKISKAHVPSWKMTLLNVCSLVNNLNSPAEETGEVH
EEELVARRKLPTALDGFSLEAMLTIYQLHKICHSRAFQHWELIQEDILDTGNDKNGKEEVIKRKIPYILKRQLYENKPRRPYILKRDSYY

--------------------------------------------------------------
>In-frame_ENST00000261183_ENST00000551529_TCGA-3B-A9HL-01A_OSBPL8_chr12_76844631_-_NTS_chr12_86270418_length(transcript)=1316nt_BP=697nt
CACTAGAATGTGAAGGATCTTCGCGGTTCTGGGTGCCCAGAAAGGCGGCGACGCGGCGGATGACAACATTAGGCCGCGACGCGCTCCTGG
CCAGGCGGCGGCTGTAGTGTTAGCTTTGGACGCCGCAGTAGCCGCTGCCGGTAGCAAGCCGACTGAGGGAAGGTGGGGGTCCGCCCGGGC
TGGTGGACCTCGGGGCCGAAAGTTCCCGCCCCGCTCGGGGGCTGAGCCGGCAGTGCCTCCGCGGCCGCTGGGCAGCGCCCTTCGTCCAGG
CTCGCGCCCCAGCTGCCGCCGACGACAGCGGCCGAGAGAAGTTGGGGTCTGACTAGACGCTTACGGGGCCTCGGACCCCGGCGCCGCGGC
GACCTCGGAGGAACCGGCTCCTTGCGTCCCGCCTCCCTGGGAGCTCCGCACGGGATTTGCAGATTTACAGAATGGCTGCACATTAATGGA
AAGAGAAGCATAAACCTATCTTCTTTCATTATGGAGGGAGGTTTGGCAGATGGAGAACCTGATCGAACTTCGCTTCTTGGTGATAGCAAA
GATGTCCTTGGGCCATCAACTGTTGTAGCAAACAGTGACGAATCTCAGCTTCTGACACCAGGAAAGATGAGTCAGCGCCAAGGAAAAGAA
GCTTATCCAACGCCAACCAAAGATTTGCATCAGCCATCTCTTAGTCCAGCAAGTCCTCATAGCCAGGATTCAGAAGAGGAAATGAAAGCA
TTAGAAGCAGATTTCTTGACCAATATGCATACATCAAAGTTAATCCAGGAAGATATTCTTGATACTGGAAATGACAAAAATGGAAAGGAA
GAAGTCATAAAGAGAAAAATTCCTTATATTCTGAAACGGCAGCTGTATGAGAATAAACCCAGAAGACCCTACATACTCAAAAGAGATTCT
TACTATTACTGAGAGAATAAATCATTTATTTACATGTGATTGTGATTCATCATCCCTTAATTAAATATCAAATTATATTTGTGTGAAAAT
GTGACAAACACACTTATCTGTCTCTTCTACAATTGTGGTTTATTGAATGTGATTTTTCTGCACTAATATAAATTAGACTAAGTGTTTTCA
AATAAATCTAAATCTTCAGCATGATGTGTTGTGTATAATTGGAGTAGATATTAATTAAGTCACCTGTATAATGTTTTGTAATTTTGCAAA
ACATATCTTGAGTTGTTTAAACAGTCAAAATGTTTGATATTTTATACCAGCTTATGAGCTCAAAGTACTACAGCAAAGCCTAGCCTGCAT

>In-frame_ENST00000261183_ENST00000551529_TCGA-3B-A9HL-01A_OSBPL8_chr12_76844631_-_NTS_chr12_86270418_length(amino acids)=209AA_start in transcript=282_stop in transcript=911
MPPTTAAERSWGLTRRLRGLGPRRRGDLGGTGSLRPASLGAPHGICRFTEWLHINGKRSINLSSFIMEGGLADGEPDRTSLLGDSKDVLG
PSTVVANSDESQLLTPGKMSQRQGKEAYPTPTKDLHQPSLSPASPHSQDSEEEMKALEADFLTNMHTSKLIQEDILDTGNDKNGKEEVIK

--------------------------------------------------------------
>In-frame_ENST00000261183_ENST00000256010_TCGA-3B-A9HL-01A_OSBPL8_chr12_76844631_-_NTS_chr12_86270418_length(transcript)=1754nt_BP=697nt
CACTAGAATGTGAAGGATCTTCGCGGTTCTGGGTGCCCAGAAAGGCGGCGACGCGGCGGATGACAACATTAGGCCGCGACGCGCTCCTGG
CCAGGCGGCGGCTGTAGTGTTAGCTTTGGACGCCGCAGTAGCCGCTGCCGGTAGCAAGCCGACTGAGGGAAGGTGGGGGTCCGCCCGGGC
TGGTGGACCTCGGGGCCGAAAGTTCCCGCCCCGCTCGGGGGCTGAGCCGGCAGTGCCTCCGCGGCCGCTGGGCAGCGCCCTTCGTCCAGG
CTCGCGCCCCAGCTGCCGCCGACGACAGCGGCCGAGAGAAGTTGGGGTCTGACTAGACGCTTACGGGGCCTCGGACCCCGGCGCCGCGGC
GACCTCGGAGGAACCGGCTCCTTGCGTCCCGCCTCCCTGGGAGCTCCGCACGGGATTTGCAGATTTACAGAATGGCTGCACATTAATGGA
AAGAGAAGCATAAACCTATCTTCTTTCATTATGGAGGGAGGTTTGGCAGATGGAGAACCTGATCGAACTTCGCTTCTTGGTGATAGCAAA
GATGTCCTTGGGCCATCAACTGTTGTAGCAAACAGTGACGAATCTCAGCTTCTGACACCAGGAAAGATGAGTCAGCGCCAAGGAAAAGAA
GCTTATCCAACGCCAACCAAAGATTTGCATCAGCCATCTCTTAGTCCAGCAAGTCCTCATAGCCAGGATTCAGAAGAGGAAATGAAAGCA
TTAGAAGCAGATTTCTTGACCAATATGCATACATCAAAGATTAGTAAAGCACATGTTCCCTCTTGGAAGATGACTCTGCTAAATGTTTGC
AGTCTTGTAAATAATTTGAACAGCCCAGCTGAGGAAACAGGAGAAGTTCATGAAGAGGAGCTTGTTGCAAGAAGGAAACTTCCTACTGCT
TTAGATGGCTTTAGCTTGGAAGCAATGTTGACAATATACCAGCTCCACAAAATCTGTCACAGCAGGGCTTTTCAACACTGGGAGTTAATC
CAGGAAGATATTCTTGATACTGGAAATGACAAAAATGGAAAGGAAGAAGTCATAAAGAGAAAAATTCCTTATATTCTGAAACGGCAGCTG
TATGAGAATAAACCCAGAAGACCCTACATACTCAAAAGAGATTCTTACTATTACTGAGAGAATAAATCATTTATTTACATGTGATTGTGA
TTCATCATCCCTTAATTAAATATCAAATTATATTTGTGTGAAAATGTGACAAACACACTTATCTGTCTCTTCTACAATTGTGGTTTATTG
AATGTGATTTTTCTGCACTAATATAAATTAGACTAAGTGTTTTCAAATAAATCTAAATCTTCAGCATGATGTGTTGTGTATAATTGGAGT
AGATATTAATTAAGTCACCTGTATAATGTTTTGTAATTTTGCAAAACATATCTTGAGTTGTTTAAACAGTCAAAATGTTTGATATTTTAT
ACCAGCTTATGAGCTCAAAGTACTACAGCAAAGCCTAGCCTGCATATCATTCACCCAAAACAAAGTAATAGCGCCTCTTTTATTATTTTG
ACTGAATGTTTTATGGAATTGAAAGAAACATACGTTCTTTTCAAGACTTCCTCATGAATCTCTCAATTATAGGAAAAGTTATTGTGATAA
AATAGGAACAGCTGAAAGATTGATTAATGAACTATTGTTAATTCTTCCTATTTTAATGAATGACATTGAACTGAATTTTTTGTCTGTTAA

>In-frame_ENST00000261183_ENST00000256010_TCGA-3B-A9HL-01A_OSBPL8_chr12_76844631_-_NTS_chr12_86270418_length(amino acids)=284AA_start in transcript=282_stop in transcript=1136
MPPTTAAERSWGLTRRLRGLGPRRRGDLGGTGSLRPASLGAPHGICRFTEWLHINGKRSINLSSFIMEGGLADGEPDRTSLLGDSKDVLG
PSTVVANSDESQLLTPGKMSQRQGKEAYPTPTKDLHQPSLSPASPHSQDSEEEMKALEADFLTNMHTSKISKAHVPSWKMTLLNVCSLVN
NLNSPAEETGEVHEEELVARRKLPTALDGFSLEAMLTIYQLHKICHSRAFQHWELIQEDILDTGNDKNGKEEVIKRKIPYILKRQLYENK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for OSBPL8-NTS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for OSBPL8-NTS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for OSBPL8-NTS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	OSBPL8	C0043094	Weight Gain	1	CTD_human
Tgene	NTS	C0036341	Schizophrenia	4	PSYGENET
Tgene	NTS	C0001973	Alcoholic Intoxication, Chronic	2	PSYGENET
Tgene	NTS	C0751217	Hyperkinesia, Generalized	2	CTD_human
Tgene	NTS	C3887506	Hyperkinesia	2	CTD_human
Tgene	NTS	C0007370	Catalepsy	1	CTD_human
Tgene	NTS	C0011570	Mental Depression	1	PSYGENET
Tgene	NTS	C0011581	Depressive disorder	1	PSYGENET
Tgene	NTS	C0026837	Muscle Rigidity	1	CTD_human
Tgene	NTS	C0151564	Cogwheel Rigidity	1	CTD_human
Tgene	NTS	C0231519	Gegenhalten	1	CTD_human
Tgene	NTS	C0233608	Catatonic Rigidity	1	CTD_human
Tgene	NTS	C0233612	Waxy flexibility	1	CTD_human
Tgene	NTS	C0239325	Extensor Rigidity	1	CTD_human
Tgene	NTS	C0277821	Extrapyramidal Rigidity	1	CTD_human
Tgene	NTS	C0428977	Bradycardia	1	CTD_human
Tgene	NTS	C0525045	Mood Disorders	1	PSYGENET
Tgene	NTS	C1320474	Nuchal Rigidity	1	CTD_human