FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:OTUD5-CHTOP (FusionGDB2 ID:61569)

Fusion Gene Summary for OTUD5-CHTOP

check button Fusion gene summary
Fusion gene informationFusion gene name: OTUD5-CHTOP
Fusion gene ID: 61569
HgeneTgene
Gene symbol

OTUD5

CHTOP

Gene ID

55593

26097

Gene nameOTU deubiquitinase 5chromatin target of PRMT1
SynonymsDUBAC10orf77|C1orf77|FL-SRAG|FOP|SRAG|SRAG-3|SRAG-5|pp7704
Cytomap

Xp11.23

1q21.3

Type of geneprotein-codingprotein-coding
DescriptionOTU domain-containing protein 5OTU domain containing 5deubiquinating enzyme Adeubiquitinating enzyme Achromatin target of PRMT1 proteinfriend of PRMT1 proteinsmall protein rich in arginine and glycine
Modification date2020031320200313
UniProtAcc.

Q9Y3Y2

Ensembl transtripts involved in fusion geneENST00000396743, ENST00000156084, 
ENST00000376488, ENST00000428668, 
ENST00000484499, 		ENST00000368694, 
ENST00000495554, ENST00000403433, 
ENST00000368690, ENST00000368687, 
ENST00000368686, 
Fusion gene scores* DoF score10 X 10 X 5=5005 X 7 X 5=175
# samples 118
** MAII scorelog2(11/500*10)=-2.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OTUD5 [Title/Abstract] AND CHTOP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOTUD5(48814474)-CHTOP(153617548), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOTUD5

GO:0016579

protein deubiquitination

22245969

HgeneOTUD5

GO:0032496

response to lipopolysaccharide

22245969

HgeneOTUD5

GO:0070536

protein K63-linked deubiquitination

22245969|23827681

HgeneOTUD5

GO:0071108

protein K48-linked deubiquitination

22245969|23827681

TgeneCHTOP

GO:0006406

mRNA export from nucleus

23299939

TgeneCHTOP

GO:0032781

positive regulation of ATPase activity

23299939

TgeneCHTOP

GO:0051096

positive regulation of helicase activity

23299939


check buttonFusion gene breakpoints across OTUD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CHTOP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABQ687057OTUD5chrX

48814474

-CHTOPchr1

153617548

+


Top

Fusion Gene ORF analysis for OTUD5-CHTOP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000396743ENST00000368694OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000396743ENST00000495554OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000396743ENST00000403433OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000396743ENST00000368690OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000396743ENST00000368687OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-intronENST00000396743ENST00000368686OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3CDSENST00000156084ENST00000368694OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000156084ENST00000495554OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000156084ENST00000403433OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000156084ENST00000368690OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000156084ENST00000368687OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-intronENST00000156084ENST00000368686OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3CDSENST00000376488ENST00000368694OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000376488ENST00000495554OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000376488ENST00000403433OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000376488ENST00000368690OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000376488ENST00000368687OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-intronENST00000376488ENST00000368686OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3CDSENST00000428668ENST00000368694OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000428668ENST00000495554OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000428668ENST00000403433OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000428668ENST00000368690OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000428668ENST00000368687OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-intronENST00000428668ENST00000368686OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3CDSENST00000484499ENST00000368694OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000484499ENST00000495554OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000484499ENST00000403433OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000484499ENST00000368690OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-3UTRENST00000484499ENST00000368687OTUD5chrX

48814474

-CHTOPchr1

153617548

+
intron-intronENST00000484499ENST00000368686OTUD5chrX

48814474

-CHTOPchr1

153617548

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for OTUD5-CHTOP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for OTUD5-CHTOP


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CHTOP

Q9Y3Y2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:19858291, ECO:0000269|PubMed:20688955, ECO:0000269|PubMed:25284789}.; FUNCTION: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939). {ECO:0000269|PubMed:23299939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for OTUD5-CHTOP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for OTUD5-CHTOP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for OTUD5-CHTOP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for OTUD5-CHTOP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource