FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARHGAP32-AHNAK (FusionGDB2 ID:6170)

Fusion Gene Summary for ARHGAP32-AHNAK

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP32-AHNAK
Fusion gene ID: 6170
HgeneTgene
Gene symbol

ARHGAP32

AHNAK

Gene ID

9743

79026

Gene nameRho GTPase activating protein 32AHNAK nucleoprotein
SynonymsGC-GAP|GRIT|PX-RICS|RICS|p200RhoGAP|p250GAPAHNAKRS|PM227
Cytomap

11q24.3

11q12.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 32GAB-associated CDC42GAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkAGTPase-activating protein for Cdc42 and Rac1RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaneuroblast differentiation-associated protein AHNAKAHNAK-relateddesmoyokin
Modification date2020032720200327
UniProtAcc

A7KAX9

Q8IVF2

Ensembl transtripts involved in fusion geneENST00000310343, ENST00000524655, 
ENST00000392657, ENST00000527272, 
ENST00000530124, ENST00000257247, 
ENST00000525875, ENST00000378024, 
Fusion gene scores* DoF score10 X 9 X 5=45024 X 16 X 9=3456
# samples 1132
** MAII scorelog2(11/450*10)=-2.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/3456*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP32 [Title/Abstract] AND AHNAK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP32(128993341)-AHNAK(62201363), # samples:3
Anticipated loss of major functional domain due to fusion event.ARHGAP32-AHNAK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARHGAP32-AHNAK seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP32 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across AHNAK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A06Z-01AARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
ChimerDB4BRCATCGA-A8-A06ZARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
ChimerDB4BRCATCGA-A8-A06Z-01AARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
ChimerDB4BRCATCGA-A8-A06Z-01AARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
ChimerDB4BRCATCGA-A8-A06Z-01AARHGAP32chr11

128993341

-AHNAKchr11

62201363

-


Top

Fusion Gene ORF analysis for ARHGAP32-AHNAK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000310343ENST00000530124ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
Frame-shiftENST00000310343ENST00000257247ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
5CDS-5UTRENST00000310343ENST00000525875ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
5CDS-intronENST00000310343ENST00000378024ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
In-frameENST00000524655ENST00000530124ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
Frame-shiftENST00000524655ENST00000257247ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
5CDS-5UTRENST00000524655ENST00000525875ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
5CDS-intronENST00000524655ENST00000378024ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
intron-3CDSENST00000392657ENST00000530124ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
intron-3CDSENST00000392657ENST00000257247ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
intron-5UTRENST00000392657ENST00000525875ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
intron-intronENST00000392657ENST00000378024ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
intron-3CDSENST00000527272ENST00000530124ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
intron-3CDSENST00000527272ENST00000257247ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
intron-5UTRENST00000527272ENST00000525875ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
intron-intronENST00000527272ENST00000378024ARHGAP32chr11

128993341

-AHNAKchr11

62201363

-
In-frameENST00000310343ENST00000530124ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
Frame-shiftENST00000310343ENST00000257247ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
5CDS-5UTRENST00000310343ENST00000525875ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
5CDS-intronENST00000310343ENST00000378024ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
In-frameENST00000524655ENST00000530124ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
Frame-shiftENST00000524655ENST00000257247ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
5CDS-5UTRENST00000524655ENST00000525875ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
5CDS-intronENST00000524655ENST00000378024ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
intron-3CDSENST00000392657ENST00000530124ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
intron-3CDSENST00000392657ENST00000257247ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
intron-5UTRENST00000392657ENST00000525875ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
intron-intronENST00000392657ENST00000378024ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
intron-3CDSENST00000527272ENST00000530124ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
intron-3CDSENST00000527272ENST00000257247ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
intron-5UTRENST00000527272ENST00000525875ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
intron-intronENST00000527272ENST00000378024ARHGAP32chr11

128993340

-AHNAKchr11

62201363

-
intron-intronENST00000310343ENST00000530124ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000310343ENST00000257247ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000310343ENST00000525875ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000310343ENST00000378024ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000524655ENST00000530124ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000524655ENST00000257247ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000524655ENST00000525875ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000524655ENST00000378024ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000392657ENST00000530124ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000392657ENST00000257247ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000392657ENST00000525875ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000392657ENST00000378024ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000527272ENST00000530124ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000527272ENST00000257247ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000527272ENST00000525875ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-
intron-intronENST00000527272ENST00000378024ARHGAP32chr11

128963526

-AHNAKchr11

62249398

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310343ARHGAP32chr11128993341-ENST00000530124AHNAKchr1162201363-7504020455151
ENST00000524655ARHGAP32chr11128993341-ENST00000530124AHNAKchr1162201363-55220455027890
ENST00000310343ARHGAP32chr11128993340-ENST00000530124AHNAKchr1162201363-7504020455151
ENST00000524655ARHGAP32chr11128993340-ENST00000530124AHNAKchr1162201363-55220455027890

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310343ENST00000530124ARHGAP32chr11128993341-AHNAKchr1162201363-0.0041080380.9958919
ENST00000524655ENST00000530124ARHGAP32chr11128993341-AHNAKchr1162201363-0.4376160.562384
ENST00000310343ENST00000530124ARHGAP32chr11128993340-AHNAKchr1162201363-0.0041080380.9958919
ENST00000524655ENST00000530124ARHGAP32chr11128993340-AHNAKchr1162201363-0.4376160.562384

Top

Fusion Genomic Features for ARHGAP32-AHNAK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ARHGAP32-AHNAK


check button Go to

FGviewer for the breakpoints of chr11:128993341-chr11:62201363

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP32

A7KAX9

AHNAK

Q8IVF2

FUNCTION: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAHNAKchr11:128993340chr11:62201363ENST00000257247465458_5654147.33333333333334150.0Compositional biasNote=Gly-rich
TgeneAHNAKchr11:128993340chr11:62201363ENST00000378024055458_565405891.0Compositional biasNote=Gly-rich
TgeneAHNAKchr11:128993341chr11:62201363ENST00000257247465458_5654147.33333333333334150.0Compositional biasNote=Gly-rich
TgeneAHNAKchr11:128993341chr11:62201363ENST00000378024055458_565405891.0Compositional biasNote=Gly-rich
TgeneAHNAKchr11:128993340chr11:62201363ENST00000378024059_9005891.0DomainPDZ
TgeneAHNAKchr11:128993341chr11:62201363ENST00000378024059_9005891.0DomainPDZ
TgeneAHNAKchr11:128993340chr11:62201363ENST00000257247464971_4979147.33333333333334150.0MotifNuclear localization signal
TgeneAHNAKchr11:128993340chr11:62201363ENST00000257247465019_5027147.33333333333334150.0MotifNuclear localization signal
TgeneAHNAKchr11:128993340chr11:62201363ENST00000257247465034_5039147.33333333333334150.0MotifNuclear localization signal
TgeneAHNAKchr11:128993340chr11:62201363ENST00000257247465706_5716147.33333333333334150.0MotifNuclear localization signal
TgeneAHNAKchr11:128993340chr11:62201363ENST00000257247465772_5779147.33333333333334150.0MotifNuclear localization signal
TgeneAHNAKchr11:128993340chr11:62201363ENST00000378024054971_497905891.0MotifNuclear localization signal
TgeneAHNAKchr11:128993340chr11:62201363ENST00000378024055019_502705891.0MotifNuclear localization signal
TgeneAHNAKchr11:128993340chr11:62201363ENST00000378024055034_503905891.0MotifNuclear localization signal
TgeneAHNAKchr11:128993340chr11:62201363ENST00000378024055706_571605891.0MotifNuclear localization signal
TgeneAHNAKchr11:128993340chr11:62201363ENST00000378024055772_577905891.0MotifNuclear localization signal
TgeneAHNAKchr11:128993341chr11:62201363ENST00000257247464971_4979147.33333333333334150.0MotifNuclear localization signal
TgeneAHNAKchr11:128993341chr11:62201363ENST00000257247465019_5027147.33333333333334150.0MotifNuclear localization signal
TgeneAHNAKchr11:128993341chr11:62201363ENST00000257247465034_5039147.33333333333334150.0MotifNuclear localization signal
TgeneAHNAKchr11:128993341chr11:62201363ENST00000257247465706_5716147.33333333333334150.0MotifNuclear localization signal
TgeneAHNAKchr11:128993341chr11:62201363ENST00000257247465772_5779147.33333333333334150.0MotifNuclear localization signal
TgeneAHNAKchr11:128993341chr11:62201363ENST00000378024054971_497905891.0MotifNuclear localization signal
TgeneAHNAKchr11:128993341chr11:62201363ENST00000378024055019_502705891.0MotifNuclear localization signal
TgeneAHNAKchr11:128993341chr11:62201363ENST00000378024055034_503905891.0MotifNuclear localization signal
TgeneAHNAKchr11:128993341chr11:62201363ENST00000378024055706_571605891.0MotifNuclear localization signal
TgeneAHNAKchr11:128993341chr11:62201363ENST00000378024055772_577905891.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000310343-4221031_1036134.02088.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000310343-4221305_1310134.02088.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000392657-1131031_103601739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000392657-1131305_131001739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000527272-1121031_103601739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000527272-1121305_131001739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000310343-4221031_1036134.02088.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000310343-4221305_1310134.02088.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000392657-1131031_103601739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000392657-1131305_131001739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000527272-1121031_103601739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000527272-1121305_131001739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000310343-422131_245134.02088.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000310343-422259_321134.02088.0DomainSH3
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000310343-422372_567134.02088.0DomainRho-GAP
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000392657-113131_24501739.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000392657-113259_32101739.0DomainSH3
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000392657-113372_56701739.0DomainRho-GAP
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000527272-112131_24501739.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000527272-112259_32101739.0DomainSH3
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000527272-112372_56701739.0DomainRho-GAP
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000310343-422131_245134.02088.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000310343-422259_321134.02088.0DomainSH3
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000310343-422372_567134.02088.0DomainRho-GAP
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000392657-113131_24501739.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000392657-113259_32101739.0DomainSH3
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000392657-113372_56701739.0DomainRho-GAP
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000527272-112131_24501739.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000527272-112259_32101739.0DomainSH3
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000527272-112372_56701739.0DomainRho-GAP
TgeneAHNAKchr11:128993340chr11:62201363ENST00000257247469_90147.33333333333334150.0DomainPDZ
TgeneAHNAKchr11:128993341chr11:62201363ENST00000257247469_90147.33333333333334150.0DomainPDZ


Top

Fusion Gene Sequence for ARHGAP32-AHNAK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000310343_ENST00000530124_TCGA-A8-A06Z-01A_ARHGAP32_chr11_128993341_-_AHNAK_chr11_62201363_length(transcript)=750nt_BP=402nt
ATGGAGACTGAAAGTGAGAGTAGCACTTTAGGGGATGACAGTGTCTTCTGGTTGGAGTCTGAAGTTATAATCCAGGTGACTGACTGTGAA
GAGGAAGAAAGGGAAGAGAAGTTCAGGAAGATGAAGTCCTCAGTACATTCTGAAGAAGATGATTTTGTTCCAGAGCTACATAGAAATGTA
CACCCTCGAGAGCGGCCTGATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTT
AAGACGTGTGGCAGTACAGCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGT
GCGCATTTCCATTATGAGAATGTTGAGTTCGGCAGCATACAGGACTGTAGAAGCGGCCAGGAAGAAAACCACCCCCTCTTAAGGTTGTTT
TTGTGACCGTTCTTTGGAGCATTGTTCTAAAAATGGGAAATTACATATTGCTGTGCCAAGGGCAACAAACACCTGCAGTTAAAGGAATAC
CTTCCGCGAGGCGGCTTTTCGGAGCATGCATGTTTATAGCTCCAGCCAGGCCAGACCGAGGGCTGCTGCATAAGCCCTGCTTGGTGCATT
TCTTTACTTGCAAGGGGACAGAGTGTGGGCTTAGGTTTGGGACTAGAGGGGGCTTTGGCAACTATGGTGCTCAGGTGATTATCCTTCGCT

>In-frame_ENST00000310343_ENST00000530124_TCGA-A8-A06Z-01A_ARHGAP32_chr11_128993341_-_AHNAK_chr11_62201363_length(amino acids)=151AA_start in transcript=0_stop in transcript=455
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTL

--------------------------------------------------------------
>In-frame_ENST00000524655_ENST00000530124_TCGA-A8-A06Z-01A_ARHGAP32_chr11_128993341_-_AHNAK_chr11_62201363_length(transcript)=552nt_BP=204nt
GATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTTAAGACGTGTGGCAGTACA
GCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGTGCGCATTTCCATTATGAG
AATGTTGAGTTCGGCAGCATACAGGACTGTAGAAGCGGCCAGGAAGAAAACCACCCCCTCTTAAGGTTGTTTTTGTGACCGTTCTTTGGA
GCATTGTTCTAAAAATGGGAAATTACATATTGCTGTGCCAAGGGCAACAAACACCTGCAGTTAAAGGAATACCTTCCGCGAGGCGGCTTT
TCGGAGCATGCATGTTTATAGCTCCAGCCAGGCCAGACCGAGGGCTGCTGCATAAGCCCTGCTTGGTGCATTTCTTTACTTGCAAGGGGA
CAGAGTGTGGGCTTAGGTTTGGGACTAGAGGGGGCTTTGGCAACTATGGTGCTCAGGTGATTATCCTTCGCTCGTTTATCCAATAAACAT

>In-frame_ENST00000524655_ENST00000530124_TCGA-A8-A06Z-01A_ARHGAP32_chr11_128993341_-_AHNAK_chr11_62201363_length(amino acids)=90AA_start in transcript=550_stop in transcript=278
MLDKCLLDKRAKDNHLSTIVAKAPSSPKPKPTLCPLASKEMHQAGLMQQPSVWPGWSYKHACSEKPPRGRYSFNCRCLLPLAQQYVISHF

--------------------------------------------------------------
>In-frame_ENST00000310343_ENST00000530124_TCGA-A8-A06Z_ARHGAP32_chr11_128993340_-_AHNAK_chr11_62201363_length(transcript)=750nt_BP=402nt
ATGGAGACTGAAAGTGAGAGTAGCACTTTAGGGGATGACAGTGTCTTCTGGTTGGAGTCTGAAGTTATAATCCAGGTGACTGACTGTGAA
GAGGAAGAAAGGGAAGAGAAGTTCAGGAAGATGAAGTCCTCAGTACATTCTGAAGAAGATGATTTTGTTCCAGAGCTACATAGAAATGTA
CACCCTCGAGAGCGGCCTGATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTT
AAGACGTGTGGCAGTACAGCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGT
GCGCATTTCCATTATGAGAATGTTGAGTTCGGCAGCATACAGGACTGTAGAAGCGGCCAGGAAGAAAACCACCCCCTCTTAAGGTTGTTT
TTGTGACCGTTCTTTGGAGCATTGTTCTAAAAATGGGAAATTACATATTGCTGTGCCAAGGGCAACAAACACCTGCAGTTAAAGGAATAC
CTTCCGCGAGGCGGCTTTTCGGAGCATGCATGTTTATAGCTCCAGCCAGGCCAGACCGAGGGCTGCTGCATAAGCCCTGCTTGGTGCATT
TCTTTACTTGCAAGGGGACAGAGTGTGGGCTTAGGTTTGGGACTAGAGGGGGCTTTGGCAACTATGGTGCTCAGGTGATTATCCTTCGCT

>In-frame_ENST00000310343_ENST00000530124_TCGA-A8-A06Z_ARHGAP32_chr11_128993340_-_AHNAK_chr11_62201363_length(amino acids)=151AA_start in transcript=0_stop in transcript=455
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTL

--------------------------------------------------------------
>In-frame_ENST00000524655_ENST00000530124_TCGA-A8-A06Z_ARHGAP32_chr11_128993340_-_AHNAK_chr11_62201363_length(transcript)=552nt_BP=204nt
GATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTTAAGACGTGTGGCAGTACA
GCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGTGCGCATTTCCATTATGAG
AATGTTGAGTTCGGCAGCATACAGGACTGTAGAAGCGGCCAGGAAGAAAACCACCCCCTCTTAAGGTTGTTTTTGTGACCGTTCTTTGGA
GCATTGTTCTAAAAATGGGAAATTACATATTGCTGTGCCAAGGGCAACAAACACCTGCAGTTAAAGGAATACCTTCCGCGAGGCGGCTTT
TCGGAGCATGCATGTTTATAGCTCCAGCCAGGCCAGACCGAGGGCTGCTGCATAAGCCCTGCTTGGTGCATTTCTTTACTTGCAAGGGGA
CAGAGTGTGGGCTTAGGTTTGGGACTAGAGGGGGCTTTGGCAACTATGGTGCTCAGGTGATTATCCTTCGCTCGTTTATCCAATAAACAT

>In-frame_ENST00000524655_ENST00000530124_TCGA-A8-A06Z_ARHGAP32_chr11_128993340_-_AHNAK_chr11_62201363_length(amino acids)=90AA_start in transcript=550_stop in transcript=278
MLDKCLLDKRAKDNHLSTIVAKAPSSPKPKPTLCPLASKEMHQAGLMQQPSVWPGWSYKHACSEKPPRGRYSFNCRCLLPLAQQYVISHF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARHGAP32-AHNAK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000310343-4221685_2087134.02088.0FYN
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000392657-1131685_208701739.0FYN
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000527272-1121685_208701739.0FYN
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000310343-4221685_2087134.02088.0FYN
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000392657-1131685_208701739.0FYN
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000527272-1121685_208701739.0FYN
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000310343-4221391_1711134.02088.0GAB2
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000392657-1131391_171101739.0GAB2
HgeneARHGAP32chr11:128993340chr11:62201363ENST00000527272-1121391_171101739.0GAB2
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000310343-4221391_1711134.02088.0GAB2
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000392657-1131391_171101739.0GAB2
HgeneARHGAP32chr11:128993341chr11:62201363ENST00000527272-1121391_171101739.0GAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARHGAP32-AHNAK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARHGAP32-AHNAK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP32C0036341Schizophrenia1PSYGENET
TgeneAHNAKC0007134Renal Cell Carcinoma1CTD_human
TgeneAHNAKC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneAHNAKC0027626Neoplasm Invasiveness1CTD_human
TgeneAHNAKC0263454Chloracne1CTD_human
TgeneAHNAKC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneAHNAKC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneAHNAKC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneAHNAKC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneAHNAKC1306837Papillary Renal Cell Carcinoma1CTD_human