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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARHGAP32-CWF19L2 (FusionGDB2 ID:6172)

Fusion Gene Summary for ARHGAP32-CWF19L2

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGAP32-CWF19L2
	Fusion gene ID: 6172
		Hgene	Tgene
	Gene symbol	ARHGAP32	CWF19L2
	Gene ID	9743	143884
	Gene name	Rho GTPase activating protein 32	CWF19 like cell cycle control factor 2
	Synonyms	GC-GAP\|GRIT\|PX-RICS\|RICS\|p200RhoGAP\|p250GAP	-
	Cytomap	11q24.3	11q22.3
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 32GAB-associated CDC42GAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkAGTPase-activating protein for Cdc42 and Rac1RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signa	CWF19-like protein 2CWF19 like 2, cell cycle control
	Modification date	20200327	20200313
	UniProtAcc	A7KAX9	Q2TBE0
	Ensembl transtripts involved in fusion gene	ENST00000310343, ENST00000524655, ENST00000392657, ENST00000527272,	ENST00000282251, ENST00000433523,
Fusion gene scores	* DoF score	10 X 9 X 5=450	5 X 4 X 4=80
	# samples	11	6
	** MAII score	log2(11/450*10)=-2.03242147769238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARHGAP32 [Title/Abstract] AND CWF19L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARHGAP32(128932175)-CWF19L2(107326502), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ARHGAP32 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CWF19L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-KK-A8II-01A	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-
ChimerDB4	PRAD	TCGA-KK-A8II	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-
ChimerDB4	PRAD	TCGA-KK-A8II-01A	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-

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Fusion Gene ORF analysis for ARHGAP32-CWF19L2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000310343	ENST00000282251	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-
In-frame	ENST00000310343	ENST00000433523	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-
In-frame	ENST00000524655	ENST00000282251	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-
In-frame	ENST00000524655	ENST00000433523	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-
intron-3CDS	ENST00000392657	ENST00000282251	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-
intron-3CDS	ENST00000392657	ENST00000433523	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-
intron-3CDS	ENST00000527272	ENST00000282251	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-
intron-3CDS	ENST00000527272	ENST00000433523	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000310343	ARHGAP32	chr11	128932175	-	ENST00000282251	CWF19L2	chr11	107326502	-	4066	921	0	3500	1166
ENST00000310343	ARHGAP32	chr11	128932175	-	ENST00000433523	CWF19L2	chr11	107326502	-	3045	921	0	3044	1014
ENST00000524655	ARHGAP32	chr11	128932175	-	ENST00000282251	CWF19L2	chr11	107326502	-	3868	723	24	3302	1092
ENST00000524655	ARHGAP32	chr11	128932175	-	ENST00000433523	CWF19L2	chr11	107326502	-	2847	723	24	2846	940

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000310343	ENST00000282251	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-	9.77E-05	0.99990237
ENST00000310343	ENST00000433523	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-	0.000326544	0.9996735
ENST00000524655	ENST00000282251	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-	0.00010647	0.99989355
ENST00000524655	ENST00000433523	ARHGAP32	chr11	128932175	-	CWF19L2	chr11	107326502	-	0.000433179	0.99956685

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Fusion Genomic Features for ARHGAP32-CWF19L2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP32-CWF19L2

Go to
FGviewer for the breakpoints of chr11:128932175-chr11:107326502
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARHGAP32 A7KAX9	CWF19L2 Q2TBE0
FUNCTION: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269\|PubMed:12446789, ECO:0000269\|PubMed:12454018, ECO:0000269\|PubMed:12531901, ECO:0000269\|PubMed:12788081, ECO:0000269\|PubMed:12819203, ECO:0000269\|PubMed:12857875, ECO:0000269\|PubMed:17663722}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000310343

131_245

307.0

2088.0

Domain

Note=PX%3B atypical

Tgene

CWF19L2

chr11:128932175

chr11:107326502

ENST00000282251

166_281

35.0

895.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CWF19L2

chr11:128932175

chr11:107326502

ENST00000282251

502_530

35.0

895.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CWF19L2

chr11:128932175

chr11:107326502

ENST00000282251

644_675

35.0

895.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CWF19L2

chr11:128932175

chr11:107326502

ENST00000433523

166_281

35.0

743.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CWF19L2

chr11:128932175

chr11:107326502

ENST00000433523

502_530

35.0

743.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CWF19L2

chr11:128932175

chr11:107326502

ENST00000433523

644_675

35.0

743.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CWF19L2

chr11:128932175

chr11:107326502

ENST00000282251

108_115

35.0

895.0

Compositional bias

Note=Poly-Ser

Tgene

CWF19L2

chr11:128932175

chr11:107326502

ENST00000282251

77_104

35.0

895.0

Compositional bias

Note=Lys-rich

Tgene

CWF19L2

chr11:128932175

chr11:107326502

ENST00000433523

108_115

35.0

743.0

Compositional bias

Note=Poly-Ser

Tgene

CWF19L2

chr11:128932175

chr11:107326502

ENST00000433523

77_104

35.0

743.0

Compositional bias

Note=Lys-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000310343

1031_1036

307.0

2088.0

Compositional bias

Note=Poly-Pro

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000310343

1305_1310

307.0

2088.0

Compositional bias

Note=Poly-Pro

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000392657

1031_1036

1739.0

Compositional bias

Note=Poly-Pro

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000392657

1305_1310

1739.0

Compositional bias

Note=Poly-Pro

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000527272

1031_1036

1739.0

Compositional bias

Note=Poly-Pro

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000527272

1305_1310

1739.0

Compositional bias

Note=Poly-Pro

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000310343

259_321

307.0

2088.0

Domain

SH3

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000310343

372_567

307.0

2088.0

Domain

Rho-GAP

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000392657

131_245

1739.0

Domain

Note=PX%3B atypical

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000392657

259_321

1739.0

Domain

SH3

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000392657

372_567

1739.0

Domain

Rho-GAP

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000527272

131_245

1739.0

Domain

Note=PX%3B atypical

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000527272

259_321

1739.0

Domain

SH3

Hgene

ARHGAP32

chr11:128932175

chr11:107326502

ENST00000527272

372_567

1739.0

Domain

Rho-GAP

Tgene

CWF19L2

chr11:128932175

chr11:107326502

ENST00000282251

13_107

35.0

895.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CWF19L2

chr11:128932175

chr11:107326502

ENST00000433523

13_107

35.0

743.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for ARHGAP32-CWF19L2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000310343_ENST00000282251_TCGA-KK-A8II-01A_ARHGAP32_chr11_128932175_-_CWF19L2_chr11_107326502_length(transcript)=4066nt_BP=921nt
ATGGAGACTGAAAGTGAGAGTAGCACTTTAGGGGATGACAGTGTCTTCTGGTTGGAGTCTGAAGTTATAATCCAGGTGACTGACTGTGAA
GAGGAAGAAAGGGAAGAGAAGTTCAGGAAGATGAAGTCCTCAGTACATTCTGAAGAAGATGATTTTGTTCCAGAGCTACATAGAAATGTA
CACCCTCGAGAGCGGCCTGATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTT
AAGACGTGTGGCAGTACAGCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGT
GCGCATTTCCATTATGAGAATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAA
TCTAAAGAGCTGGTCTACCTCGTGCAGATTGCTTGTCAGGGAAAAAGTTGGATTGTTAAAAGAAGTTATGAAGATTTTCGGGTACTTGAT
AAACATCTTCATCTGTGTATTTATGACCGAAGATTTTCCCAGCTCTCAGAACTTCCCCGTTCTGACACCCTGAAGGACAGTCCAGAGTCG
GTCACTCAGATGCTTATGGCTTACCTGTCACGCCTTTCAGCTATCGCTGGCAACAAGATCAACTGTGGGCCCGCCCTTACCTGGATGGAG
ATTGATAATAAGGGAAATCACCTTTTGGTTCATGAGGAGTCATCCATCAACACTCCTGCTGTCGGTGCTGCCCATGTTATCAAGAGGTAC
ACTGCTCGGGCCCCTGACGAACTGACCTTAGAGGTGGGAGACATTGTTTCTGTTATTGACATGCCCCCGAAAGTGTTAAGCACATGGTGG
AGAGGCAAGCACGGATTCCAGGCTAAAGCCAATTTTGAAAAAGAAGAAAGGCGTAAAGAACTTAAGCGACTTCGGGGTGAGGATACATGG
ATGCTACCTGATGTGAATGAGAGAATTGAACAGTTCTCACAGGAACACTCTGTGAAGAAAAAGAAGAAAAAAGACAAGCATTCAAAAAAA
GCAAAGAAAGAAAAGAAAAAAAAGAGCAAGAAACAGAAATATGAAAAAAACAATGAGTCATCTGATAGCTCATCAAGCTCTGAAGATGAG
TGGGTTGAGGCTGTTCCATCCCAGACTCCTGACAAGGAAAAAGCCTGGAAAGTGAAAGATGAAAAGTCAGGAAAAGATGACACCCAAATT
ATCAAGAGGGATGAGTGGATGACTGTTGATTTTATGTCTGTTAAAACTGTGTCATCATCATCACTCAAAGCTGAAAAGGAAACTATGAGG
AAAATAGAGCAAGAGAAAAACCAAGCGCTTGAACAGTCCAAACTGATGGAAAGAGAATTGAATCCGTACTGGAAGGATGGTGGGACAGGT
CTTCCACCTGAAGACTGTAGTGTGTCATCGATTACTAAAGTTTCAGTGGTAGAAGATGGTGGATTAAGCTGGCTAAGGAAATCTTATCTA
AGAATGAAGGAACAAGCTGAGAAACAAAGTAGAAACTTTGAGGACATTGTAGCCGAAAGATATGGGTCAATGGAAATATTTCAGTCAAAA
TTAGAAGATGCTGAAAAAGCTGCATCCACGAAAGAAGATTATAGACGGGAACGGTGGAGGAAACCCACATATTCAGATAAAGCACAAAAT
TGTCAAGAAAGTAGAGAATCAGACTTAGTAAAATATGGTAACAGTTCAAGGGATAGATATGCTACAACAGATACTGCAAAAAATAGCAAT
AATGAAAAATTTATTGGTGATGAAAAAGATAAGAGACCTGGGTCTTTAGAAACGTGTAGAAGAGAATCTAACCCAAGGCAAAATCAAGAG
TTTTCTTTTGGCAATTTGAGAGCTAAATTCTTGAGACCCTCTGATGATGAAGAACTGTCATTTCACAGCAAGGGCAGAAAATTTGAACCA
CTTAGTTCATCTTCAGCATTGGTAGCTCAGGGCTCTTTGTGTAGTGGTTTTAGAAAACCCACCAAGAACAGTGAAGAAAGATTAACATCA
TGGAGTCGCTCTGATGGGAGAGGAGACAAGAAACATTCAAATCAAAAGCCATCGGAAACCAGTACTGATGAACACCAACATGTTCCAGAA
GACCCAAGAGAAAAATCACAAGATGAAGTCTTGAGAGATGACCCTCCAAAAAAAGAACATCTACGGGATACAAAGTCTACATTTGCTGGC
AGTCCAGAGCGTGAGTCCATTCACATCCTGAGTGTTGATGAGAAGAACAAGTTGGGAGCCAAGATTATCAAAGCAGAGATGATGGGGAAT
ATGGAATTAGCTGAACAACTTAAAGTTCAACTTGAAAAGGCAAATAAATTCAAAGAAACTATAACACAGATACCAAAAAAATCTGGGGTA
GAGAATGAAGACCAGCAAGAAGTAATCCTTGTCAGAACAGATCAGTCTGGAAGAGTATGGCCTGTGAACACACCCGGAAAATCTCTGGAA
TCACAAGGAGGAAGAAGAAAGAGACAGATGGTTTCAACCCATGAGGAAAGAGAAAGGGTCAGATACTTTCATGATGATGATAATCTAAGC
CTAAATGATTTAGTCAAAAATGAAAAGATGGGAACAGCAGAAAATCAAAACAAGCTCTTTATGAGAATGGCATCTAAGTTTATGGGAAAA
ACAGATGGAGACTATTACACCCTGGATGACATGTTTGTCTCCAAAGCAGCTGAGAGAGAACGTCTTGGTGAAGAGGAAGAGAACCAAAGG
AAAAAAGCTATTGCTGAGCATCGGAGTCTTGCTGCACAAATGGAAAAATGTCTGTATTGTTTTGACAGCTCTCAATTTCCCAAGCATCTT
ATTGTTGCAATAGGTGTTAAGGTTTATTTATGTTTACCCAACGTACGGTCTCTTACTGAGGGGCACTGCCTGATAGTCCCTTTGCAGCAC
CATAGAGCAGCTACTTTGTTGGATGAAGACATCTGGGAGGAGATCCAGATGTTCAGAAAATCATTGGTAAAGATGTTTGAAGATAAAGGA
TTAGACTGCATTTTTTTGGAAACTAATATGAGCATGAAGAAACAGTATCACATGGTTTATGAATGTATTCCTCTTCCCAAGGAAGTGGGT
GACATGGCTCCCATCTATTTTAAGAAAGCCATAATGGAATCTGATGAAGAGTGGTCCATGAACAAGAAGTTGATAGATCTCTCTTCAAAA
GATATCAGAAAGTCTGTACCCAGAGGGTTACCTTACTTCTCTGTGGATTTTGGCCTTCACGGAGGGTTTGCCCATGTCATTGAAGATCAG
CACAAATTCCCTCATTACTTTGGAAAGGAAATCATAGGTGGGATGCTGGATATAGAACCAAGACTTTGGAGGAAAGGCATCCGAGAAAGC
TTTGAGGATCAGAGGAAAAAAGCACTGCAGTTTGCTCAGTGGTGGAAACCATATGACTTCACCAAAAGTAAAAACTATTGAGGTGTACCT
TCCATTTTAAAATTTTTCTTCAGATCCCGTTCAGTTTTATTTCCATTGCATCTAATGAAGCAACTGACCCTCAGGTCACAGGCAGAGAGA
GTCACAGCAGCAGACTGCTCTGGGTCAGTGACAACTGTACATCAGGAGATTGTGTTGTTTTCTTCTTCACCTGCTCCTATCTATGGACTT
CATTTTAGTCACCATGGAGTAAAAACATATATTCGATGATCTGCTCACATTCCTGCTCTCTACCTACTTCTTGGTATTCCGAATTGTTCA
GTTAATTTAGAGAAGGCCTTTTCTGAAGGGATATCTAAAAAGCATAGGAAATCCTTGGTTCAGAGGGAAGTGGGTCTGCTTCATGGTTGT
TAAGTCTACTGTCTGGCTTCTTTTGCATTTTTAAAAATAAGACGATTTAATTTTAATTTCATAGGATTTTATAGAAAAGCTCTTAATTTT
CTACTAGCAGTATATAGTATCACTTCTATTCTTTTTGTTAAAGGAAAAGGAAATGTCCCCAAAGTATTAAAGAATTAAATGATACTGAAA

>In-frame_ENST00000310343_ENST00000282251_TCGA-KK-A8II-01A_ARHGAP32_chr11_128932175_-_CWF19L2_chr11_107326502_length(amino acids)=1166AA_start in transcript=0_stop in transcript=3500
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTL
KTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLD
KHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRY
TARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQAKANFEKEERRKELKRLRGEDTWMLPDVNERIEQFSQEHSVKKKKKKDKHSKK
AKKEKKKKSKKQKYEKNNESSDSSSSSEDEWVEAVPSQTPDKEKAWKVKDEKSGKDDTQIIKRDEWMTVDFMSVKTVSSSSLKAEKETMR
KIEQEKNQALEQSKLMERELNPYWKDGGTGLPPEDCSVSSITKVSVVEDGGLSWLRKSYLRMKEQAEKQSRNFEDIVAERYGSMEIFQSK
LEDAEKAASTKEDYRRERWRKPTYSDKAQNCQESRESDLVKYGNSSRDRYATTDTAKNSNNEKFIGDEKDKRPGSLETCRRESNPRQNQE
FSFGNLRAKFLRPSDDEELSFHSKGRKFEPLSSSSALVAQGSLCSGFRKPTKNSEERLTSWSRSDGRGDKKHSNQKPSETSTDEHQHVPE
DPREKSQDEVLRDDPPKKEHLRDTKSTFAGSPERESIHILSVDEKNKLGAKIIKAEMMGNMELAEQLKVQLEKANKFKETITQIPKKSGV
ENEDQQEVILVRTDQSGRVWPVNTPGKSLESQGGRRKRQMVSTHEERERVRYFHDDDNLSLNDLVKNEKMGTAENQNKLFMRMASKFMGK
TDGDYYTLDDMFVSKAAERERLGEEEENQRKKAIAEHRSLAAQMEKCLYCFDSSQFPKHLIVAIGVKVYLCLPNVRSLTEGHCLIVPLQH
HRAATLLDEDIWEEIQMFRKSLVKMFEDKGLDCIFLETNMSMKKQYHMVYECIPLPKEVGDMAPIYFKKAIMESDEEWSMNKKLIDLSSK

--------------------------------------------------------------
>In-frame_ENST00000310343_ENST00000433523_TCGA-KK-A8II-01A_ARHGAP32_chr11_128932175_-_CWF19L2_chr11_107326502_length(transcript)=3045nt_BP=921nt
ATGGAGACTGAAAGTGAGAGTAGCACTTTAGGGGATGACAGTGTCTTCTGGTTGGAGTCTGAAGTTATAATCCAGGTGACTGACTGTGAA
GAGGAAGAAAGGGAAGAGAAGTTCAGGAAGATGAAGTCCTCAGTACATTCTGAAGAAGATGATTTTGTTCCAGAGCTACATAGAAATGTA
CACCCTCGAGAGCGGCCTGATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTT
AAGACGTGTGGCAGTACAGCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGT
GCGCATTTCCATTATGAGAATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAA
TCTAAAGAGCTGGTCTACCTCGTGCAGATTGCTTGTCAGGGAAAAAGTTGGATTGTTAAAAGAAGTTATGAAGATTTTCGGGTACTTGAT
AAACATCTTCATCTGTGTATTTATGACCGAAGATTTTCCCAGCTCTCAGAACTTCCCCGTTCTGACACCCTGAAGGACAGTCCAGAGTCG
GTCACTCAGATGCTTATGGCTTACCTGTCACGCCTTTCAGCTATCGCTGGCAACAAGATCAACTGTGGGCCCGCCCTTACCTGGATGGAG
ATTGATAATAAGGGAAATCACCTTTTGGTTCATGAGGAGTCATCCATCAACACTCCTGCTGTCGGTGCTGCCCATGTTATCAAGAGGTAC
ACTGCTCGGGCCCCTGACGAACTGACCTTAGAGGTGGGAGACATTGTTTCTGTTATTGACATGCCCCCGAAAGTGTTAAGCACATGGTGG
AGAGGCAAGCACGGATTCCAGGCTAAAGCCAATTTTGAAAAAGAAGAAAGGCGTAAAGAACTTAAGCGACTTCGGGGTGAGGATACATGG
ATGCTACCTGATGTGAATGAGAGAATTGAACAGTTCTCACAGGAACACTCTGTGAAGAAAAAGAAGAAAAAAGACAAGCATTCAAAAAAA
GCAAAGAAAGAAAAGAAAAAAAAGAGCAAGAAACAGAAATATGAAAAAAACAATGAGTCATCTGATAGCTCATCAAGCTCTGAAGATGAG
TGGGTTGAGGCTGTTCCATCCCAGACTCCTGACAAGGAAAAAGCCTGGAAAGTGAAAGATGAAAAGTCAGGAAAAGATGACACCCAAATT
ATCAAGAGGGATGAGTGGATGACTGTTGATTTTATGTCTGTTAAAACTGTGTCATCATCATCACTCAAAGCTGAAAAGGAAACTATGAGG
AAAATAGAGCAAGAGAAAAACCAAGCGCTTGAACAGTCCAAACTGATGGAAAGAGAATTGAATCCGTACTGGAAGGATGGTGGGACAGGT
CTTCCACCTGAAGACTGTAGTGTGTCATCGATTACTAAAGTTTCAGTGGTAGAAGATGGTGGATTAAGCTGGCTAAGGAAATCTTATCTA
AGAATGAAGGAACAAGCTGAGAAACAAAGTAGAAACTTTGAGGACATTGTAGCCGAAAGATATGGGTCAATGGAAATATTTCAGTCAAAA
TTAGAAGATGCTGAAAAAGCTGCATCCACGAAAGAAGATTATAGACGGGAACGGTGGAGGAAACCCACATATTCAGATAAAGCACAAAAT
TGTCAAGAAAGTAGAGAATCAGACTTAGTAAAATATGGTAACAGTTCAAGGGATAGATATGCTACAACAGATACTGCAAAAAATAGCAAT
AATGAAAAATTTATTGGTGATGAAAAAGATAAGAGACCTGGGTCTTTAGAAACGTGTAGAAGAGAATCTAACCCAAGGCAAAATCAAGAG
TTTTCTTTTGGCAATTTGAGAGCTAAATTCTTGAGACCCTCTGATGATGAAGAACTGTCATTTCACAGCAAGGGCAGAAAATTTGAACCA
CTTAGTTCATCTTCAGCATTGGTAGCTCAGGGCTCTTTGTGTAGTGGTTTTAGAAAACCCACCAAGAACAGTGAAGAAAGATTAACATCA
TGGAGTCGCTCTGATGGGAGAGGAGACAAGAAACATTCAAATCAAAAGCCATCGGAAACCAGTACTGATGAACACCAACATGTTCCAGAA
GACCCAAGAGAAAAATCACAAGATGAAGTCTTGAGAGATGACCCTCCAAAAAAAGAACATCTACGGGATACAAAGTCTACATTTGCTGGC
AGTCCAGAGCGTGAGTCCATTCACATCCTGAGTGTTGATGAGAAGAACAAGTTGGGAGCCAAGATTATCAAAGCAGAGATGATGGGGAAT
ATGGAATTAGCTGAACAACTTAAAGTTCAACTTGAAAAGGCAAATAAATTCAAAGAAACTATAACACAGATACCAAAAAAATCTGGGGTA
GAGAATGAAGACCAGCAAGAAGTAATCCTTGTCAGAACAGATCAGTCTGGAAGAGTATGGCCTGTGAACACACCCGGAAAATCTCTGGAA
TCACAAGGAGGAAGAAGAAAGAGACAGATGGTTTCAACCCATGAGGAAAGAGAAAGGGTCAGATACTTTCATGATGATGATAATCTAAGC
CTAAATGATTTAGTCAAAAATGAAAAGATGGGAACAGCAGAAAATCAAAACAAGCTCTTTATGAGAATGGCATCTAAGTTTATGGGAAAA
ACAGATGGAGACTATTACACCCTGGATGACATGTTTGTCTCCAAAGCAGCTGAGAGAGAACGTCTTGGTGAAGAGGAAGAGAACCAAAGG
AAAAAAGCTATTGCTGAGCATCGGAGTCTTGCTGCACAAATGGAAAAATGTCTGTATTGTTTTGACAGCTCTCAATTTCCCAAGCATCTT
ATTGTTGCAATAGGTGTTAAGGTTTATTTATGTTTACCCAACGTACGGTCTCTTACTGAGGGGCACTGCCTGATAGTCCCTTTGCAGCAC

>In-frame_ENST00000310343_ENST00000433523_TCGA-KK-A8II-01A_ARHGAP32_chr11_128932175_-_CWF19L2_chr11_107326502_length(amino acids)=1014AA_start in transcript=0_stop in transcript=3044
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTL
KTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLD
KHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRY
TARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQAKANFEKEERRKELKRLRGEDTWMLPDVNERIEQFSQEHSVKKKKKKDKHSKK
AKKEKKKKSKKQKYEKNNESSDSSSSSEDEWVEAVPSQTPDKEKAWKVKDEKSGKDDTQIIKRDEWMTVDFMSVKTVSSSSLKAEKETMR
KIEQEKNQALEQSKLMERELNPYWKDGGTGLPPEDCSVSSITKVSVVEDGGLSWLRKSYLRMKEQAEKQSRNFEDIVAERYGSMEIFQSK
LEDAEKAASTKEDYRRERWRKPTYSDKAQNCQESRESDLVKYGNSSRDRYATTDTAKNSNNEKFIGDEKDKRPGSLETCRRESNPRQNQE
FSFGNLRAKFLRPSDDEELSFHSKGRKFEPLSSSSALVAQGSLCSGFRKPTKNSEERLTSWSRSDGRGDKKHSNQKPSETSTDEHQHVPE
DPREKSQDEVLRDDPPKKEHLRDTKSTFAGSPERESIHILSVDEKNKLGAKIIKAEMMGNMELAEQLKVQLEKANKFKETITQIPKKSGV
ENEDQQEVILVRTDQSGRVWPVNTPGKSLESQGGRRKRQMVSTHEERERVRYFHDDDNLSLNDLVKNEKMGTAENQNKLFMRMASKFMGK
TDGDYYTLDDMFVSKAAERERLGEEEENQRKKAIAEHRSLAAQMEKCLYCFDSSQFPKHLIVAIGVKVYLCLPNVRSLTEGHCLIVPLQH

--------------------------------------------------------------
>In-frame_ENST00000524655_ENST00000282251_TCGA-KK-A8II-01A_ARHGAP32_chr11_128932175_-_CWF19L2_chr11_107326502_length(transcript)=3868nt_BP=723nt
GATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTTAAGACGTGTGGCAGTACA
GCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGTGCGCATTTCCATTATGAG
AATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAATCTAAAGAGCTGGTCTAC
CTCGTGCAGATTGCTTGTCAGGGAAAAAGTTGGATTGTTAAAAGAAGTTATGAAGATTTTCGGGTACTTGATAAACATCTTCATCTGTGT
ATTTATGACCGAAGATTTTCCCAGCTCTCAGAACTTCCCCGTTCTGACACCCTGAAGGACAGTCCAGAGTCGGTCACTCAGATGCTTATG
GCTTACCTGTCACGCCTTTCAGCTATCGCTGGCAACAAGATCAACTGTGGGCCCGCCCTTACCTGGATGGAGATTGATAATAAGGGAAAT
CACCTTTTGGTTCATGAGGAGTCATCCATCAACACTCCTGCTGTCGGTGCTGCCCATGTTATCAAGAGGTACACTGCTCGGGCCCCTGAC
GAACTGACCTTAGAGGTGGGAGACATTGTTTCTGTTATTGACATGCCCCCGAAAGTGTTAAGCACATGGTGGAGAGGCAAGCACGGATTC
CAGGCTAAAGCCAATTTTGAAAAAGAAGAAAGGCGTAAAGAACTTAAGCGACTTCGGGGTGAGGATACATGGATGCTACCTGATGTGAAT
GAGAGAATTGAACAGTTCTCACAGGAACACTCTGTGAAGAAAAAGAAGAAAAAAGACAAGCATTCAAAAAAAGCAAAGAAAGAAAAGAAA
AAAAAGAGCAAGAAACAGAAATATGAAAAAAACAATGAGTCATCTGATAGCTCATCAAGCTCTGAAGATGAGTGGGTTGAGGCTGTTCCA
TCCCAGACTCCTGACAAGGAAAAAGCCTGGAAAGTGAAAGATGAAAAGTCAGGAAAAGATGACACCCAAATTATCAAGAGGGATGAGTGG
ATGACTGTTGATTTTATGTCTGTTAAAACTGTGTCATCATCATCACTCAAAGCTGAAAAGGAAACTATGAGGAAAATAGAGCAAGAGAAA
AACCAAGCGCTTGAACAGTCCAAACTGATGGAAAGAGAATTGAATCCGTACTGGAAGGATGGTGGGACAGGTCTTCCACCTGAAGACTGT
AGTGTGTCATCGATTACTAAAGTTTCAGTGGTAGAAGATGGTGGATTAAGCTGGCTAAGGAAATCTTATCTAAGAATGAAGGAACAAGCT
GAGAAACAAAGTAGAAACTTTGAGGACATTGTAGCCGAAAGATATGGGTCAATGGAAATATTTCAGTCAAAATTAGAAGATGCTGAAAAA
GCTGCATCCACGAAAGAAGATTATAGACGGGAACGGTGGAGGAAACCCACATATTCAGATAAAGCACAAAATTGTCAAGAAAGTAGAGAA
TCAGACTTAGTAAAATATGGTAACAGTTCAAGGGATAGATATGCTACAACAGATACTGCAAAAAATAGCAATAATGAAAAATTTATTGGT
GATGAAAAAGATAAGAGACCTGGGTCTTTAGAAACGTGTAGAAGAGAATCTAACCCAAGGCAAAATCAAGAGTTTTCTTTTGGCAATTTG
AGAGCTAAATTCTTGAGACCCTCTGATGATGAAGAACTGTCATTTCACAGCAAGGGCAGAAAATTTGAACCACTTAGTTCATCTTCAGCA
TTGGTAGCTCAGGGCTCTTTGTGTAGTGGTTTTAGAAAACCCACCAAGAACAGTGAAGAAAGATTAACATCATGGAGTCGCTCTGATGGG
AGAGGAGACAAGAAACATTCAAATCAAAAGCCATCGGAAACCAGTACTGATGAACACCAACATGTTCCAGAAGACCCAAGAGAAAAATCA
CAAGATGAAGTCTTGAGAGATGACCCTCCAAAAAAAGAACATCTACGGGATACAAAGTCTACATTTGCTGGCAGTCCAGAGCGTGAGTCC
ATTCACATCCTGAGTGTTGATGAGAAGAACAAGTTGGGAGCCAAGATTATCAAAGCAGAGATGATGGGGAATATGGAATTAGCTGAACAA
CTTAAAGTTCAACTTGAAAAGGCAAATAAATTCAAAGAAACTATAACACAGATACCAAAAAAATCTGGGGTAGAGAATGAAGACCAGCAA
GAAGTAATCCTTGTCAGAACAGATCAGTCTGGAAGAGTATGGCCTGTGAACACACCCGGAAAATCTCTGGAATCACAAGGAGGAAGAAGA
AAGAGACAGATGGTTTCAACCCATGAGGAAAGAGAAAGGGTCAGATACTTTCATGATGATGATAATCTAAGCCTAAATGATTTAGTCAAA
AATGAAAAGATGGGAACAGCAGAAAATCAAAACAAGCTCTTTATGAGAATGGCATCTAAGTTTATGGGAAAAACAGATGGAGACTATTAC
ACCCTGGATGACATGTTTGTCTCCAAAGCAGCTGAGAGAGAACGTCTTGGTGAAGAGGAAGAGAACCAAAGGAAAAAAGCTATTGCTGAG
CATCGGAGTCTTGCTGCACAAATGGAAAAATGTCTGTATTGTTTTGACAGCTCTCAATTTCCCAAGCATCTTATTGTTGCAATAGGTGTT
AAGGTTTATTTATGTTTACCCAACGTACGGTCTCTTACTGAGGGGCACTGCCTGATAGTCCCTTTGCAGCACCATAGAGCAGCTACTTTG
TTGGATGAAGACATCTGGGAGGAGATCCAGATGTTCAGAAAATCATTGGTAAAGATGTTTGAAGATAAAGGATTAGACTGCATTTTTTTG
GAAACTAATATGAGCATGAAGAAACAGTATCACATGGTTTATGAATGTATTCCTCTTCCCAAGGAAGTGGGTGACATGGCTCCCATCTAT
TTTAAGAAAGCCATAATGGAATCTGATGAAGAGTGGTCCATGAACAAGAAGTTGATAGATCTCTCTTCAAAAGATATCAGAAAGTCTGTA
CCCAGAGGGTTACCTTACTTCTCTGTGGATTTTGGCCTTCACGGAGGGTTTGCCCATGTCATTGAAGATCAGCACAAATTCCCTCATTAC
TTTGGAAAGGAAATCATAGGTGGGATGCTGGATATAGAACCAAGACTTTGGAGGAAAGGCATCCGAGAAAGCTTTGAGGATCAGAGGAAA
AAAGCACTGCAGTTTGCTCAGTGGTGGAAACCATATGACTTCACCAAAAGTAAAAACTATTGAGGTGTACCTTCCATTTTAAAATTTTTC
TTCAGATCCCGTTCAGTTTTATTTCCATTGCATCTAATGAAGCAACTGACCCTCAGGTCACAGGCAGAGAGAGTCACAGCAGCAGACTGC
TCTGGGTCAGTGACAACTGTACATCAGGAGATTGTGTTGTTTTCTTCTTCACCTGCTCCTATCTATGGACTTCATTTTAGTCACCATGGA
GTAAAAACATATATTCGATGATCTGCTCACATTCCTGCTCTCTACCTACTTCTTGGTATTCCGAATTGTTCAGTTAATTTAGAGAAGGCC
TTTTCTGAAGGGATATCTAAAAAGCATAGGAAATCCTTGGTTCAGAGGGAAGTGGGTCTGCTTCATGGTTGTTAAGTCTACTGTCTGGCT
TCTTTTGCATTTTTAAAAATAAGACGATTTAATTTTAATTTCATAGGATTTTATAGAAAAGCTCTTAATTTTCTACTAGCAGTATATAGT

>In-frame_ENST00000524655_ENST00000282251_TCGA-KK-A8II-01A_ARHGAP32_chr11_128932175_-_CWF19L2_chr11_107326502_length(amino acids)=1092AA_start in transcript=24_stop in transcript=3302
MARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQG
KSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEES
SINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQAKANFEKEERRKELKRLRGEDTWMLPDVNERIEQFSQ
EHSVKKKKKKDKHSKKAKKEKKKKSKKQKYEKNNESSDSSSSSEDEWVEAVPSQTPDKEKAWKVKDEKSGKDDTQIIKRDEWMTVDFMSV
KTVSSSSLKAEKETMRKIEQEKNQALEQSKLMERELNPYWKDGGTGLPPEDCSVSSITKVSVVEDGGLSWLRKSYLRMKEQAEKQSRNFE
DIVAERYGSMEIFQSKLEDAEKAASTKEDYRRERWRKPTYSDKAQNCQESRESDLVKYGNSSRDRYATTDTAKNSNNEKFIGDEKDKRPG
SLETCRRESNPRQNQEFSFGNLRAKFLRPSDDEELSFHSKGRKFEPLSSSSALVAQGSLCSGFRKPTKNSEERLTSWSRSDGRGDKKHSN
QKPSETSTDEHQHVPEDPREKSQDEVLRDDPPKKEHLRDTKSTFAGSPERESIHILSVDEKNKLGAKIIKAEMMGNMELAEQLKVQLEKA
NKFKETITQIPKKSGVENEDQQEVILVRTDQSGRVWPVNTPGKSLESQGGRRKRQMVSTHEERERVRYFHDDDNLSLNDLVKNEKMGTAE
NQNKLFMRMASKFMGKTDGDYYTLDDMFVSKAAERERLGEEEENQRKKAIAEHRSLAAQMEKCLYCFDSSQFPKHLIVAIGVKVYLCLPN
VRSLTEGHCLIVPLQHHRAATLLDEDIWEEIQMFRKSLVKMFEDKGLDCIFLETNMSMKKQYHMVYECIPLPKEVGDMAPIYFKKAIMES
DEEWSMNKKLIDLSSKDIRKSVPRGLPYFSVDFGLHGGFAHVIEDQHKFPHYFGKEIIGGMLDIEPRLWRKGIRESFEDQRKKALQFAQW

--------------------------------------------------------------
>In-frame_ENST00000524655_ENST00000433523_TCGA-KK-A8II-01A_ARHGAP32_chr11_128932175_-_CWF19L2_chr11_107326502_length(transcript)=2847nt_BP=723nt
GATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTTAAGACGTGTGGCAGTACA
GCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGTGCGCATTTCCATTATGAG
AATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAATCTAAAGAGCTGGTCTAC
CTCGTGCAGATTGCTTGTCAGGGAAAAAGTTGGATTGTTAAAAGAAGTTATGAAGATTTTCGGGTACTTGATAAACATCTTCATCTGTGT
ATTTATGACCGAAGATTTTCCCAGCTCTCAGAACTTCCCCGTTCTGACACCCTGAAGGACAGTCCAGAGTCGGTCACTCAGATGCTTATG
GCTTACCTGTCACGCCTTTCAGCTATCGCTGGCAACAAGATCAACTGTGGGCCCGCCCTTACCTGGATGGAGATTGATAATAAGGGAAAT
CACCTTTTGGTTCATGAGGAGTCATCCATCAACACTCCTGCTGTCGGTGCTGCCCATGTTATCAAGAGGTACACTGCTCGGGCCCCTGAC
GAACTGACCTTAGAGGTGGGAGACATTGTTTCTGTTATTGACATGCCCCCGAAAGTGTTAAGCACATGGTGGAGAGGCAAGCACGGATTC
CAGGCTAAAGCCAATTTTGAAAAAGAAGAAAGGCGTAAAGAACTTAAGCGACTTCGGGGTGAGGATACATGGATGCTACCTGATGTGAAT
GAGAGAATTGAACAGTTCTCACAGGAACACTCTGTGAAGAAAAAGAAGAAAAAAGACAAGCATTCAAAAAAAGCAAAGAAAGAAAAGAAA
AAAAAGAGCAAGAAACAGAAATATGAAAAAAACAATGAGTCATCTGATAGCTCATCAAGCTCTGAAGATGAGTGGGTTGAGGCTGTTCCA
TCCCAGACTCCTGACAAGGAAAAAGCCTGGAAAGTGAAAGATGAAAAGTCAGGAAAAGATGACACCCAAATTATCAAGAGGGATGAGTGG
ATGACTGTTGATTTTATGTCTGTTAAAACTGTGTCATCATCATCACTCAAAGCTGAAAAGGAAACTATGAGGAAAATAGAGCAAGAGAAA
AACCAAGCGCTTGAACAGTCCAAACTGATGGAAAGAGAATTGAATCCGTACTGGAAGGATGGTGGGACAGGTCTTCCACCTGAAGACTGT
AGTGTGTCATCGATTACTAAAGTTTCAGTGGTAGAAGATGGTGGATTAAGCTGGCTAAGGAAATCTTATCTAAGAATGAAGGAACAAGCT
GAGAAACAAAGTAGAAACTTTGAGGACATTGTAGCCGAAAGATATGGGTCAATGGAAATATTTCAGTCAAAATTAGAAGATGCTGAAAAA
GCTGCATCCACGAAAGAAGATTATAGACGGGAACGGTGGAGGAAACCCACATATTCAGATAAAGCACAAAATTGTCAAGAAAGTAGAGAA
TCAGACTTAGTAAAATATGGTAACAGTTCAAGGGATAGATATGCTACAACAGATACTGCAAAAAATAGCAATAATGAAAAATTTATTGGT
GATGAAAAAGATAAGAGACCTGGGTCTTTAGAAACGTGTAGAAGAGAATCTAACCCAAGGCAAAATCAAGAGTTTTCTTTTGGCAATTTG
AGAGCTAAATTCTTGAGACCCTCTGATGATGAAGAACTGTCATTTCACAGCAAGGGCAGAAAATTTGAACCACTTAGTTCATCTTCAGCA
TTGGTAGCTCAGGGCTCTTTGTGTAGTGGTTTTAGAAAACCCACCAAGAACAGTGAAGAAAGATTAACATCATGGAGTCGCTCTGATGGG
AGAGGAGACAAGAAACATTCAAATCAAAAGCCATCGGAAACCAGTACTGATGAACACCAACATGTTCCAGAAGACCCAAGAGAAAAATCA
CAAGATGAAGTCTTGAGAGATGACCCTCCAAAAAAAGAACATCTACGGGATACAAAGTCTACATTTGCTGGCAGTCCAGAGCGTGAGTCC
ATTCACATCCTGAGTGTTGATGAGAAGAACAAGTTGGGAGCCAAGATTATCAAAGCAGAGATGATGGGGAATATGGAATTAGCTGAACAA
CTTAAAGTTCAACTTGAAAAGGCAAATAAATTCAAAGAAACTATAACACAGATACCAAAAAAATCTGGGGTAGAGAATGAAGACCAGCAA
GAAGTAATCCTTGTCAGAACAGATCAGTCTGGAAGAGTATGGCCTGTGAACACACCCGGAAAATCTCTGGAATCACAAGGAGGAAGAAGA
AAGAGACAGATGGTTTCAACCCATGAGGAAAGAGAAAGGGTCAGATACTTTCATGATGATGATAATCTAAGCCTAAATGATTTAGTCAAA
AATGAAAAGATGGGAACAGCAGAAAATCAAAACAAGCTCTTTATGAGAATGGCATCTAAGTTTATGGGAAAAACAGATGGAGACTATTAC
ACCCTGGATGACATGTTTGTCTCCAAAGCAGCTGAGAGAGAACGTCTTGGTGAAGAGGAAGAGAACCAAAGGAAAAAAGCTATTGCTGAG
CATCGGAGTCTTGCTGCACAAATGGAAAAATGTCTGTATTGTTTTGACAGCTCTCAATTTCCCAAGCATCTTATTGTTGCAATAGGTGTT
AAGGTTTATTTATGTTTACCCAACGTACGGTCTCTTACTGAGGGGCACTGCCTGATAGTCCCTTTGCAGCACCATAGAGCAGCTACTTTG

>In-frame_ENST00000524655_ENST00000433523_TCGA-KK-A8II-01A_ARHGAP32_chr11_128932175_-_CWF19L2_chr11_107326502_length(amino acids)=940AA_start in transcript=24_stop in transcript=2846
MARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQG
KSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEES
SINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQAKANFEKEERRKELKRLRGEDTWMLPDVNERIEQFSQ
EHSVKKKKKKDKHSKKAKKEKKKKSKKQKYEKNNESSDSSSSSEDEWVEAVPSQTPDKEKAWKVKDEKSGKDDTQIIKRDEWMTVDFMSV
KTVSSSSLKAEKETMRKIEQEKNQALEQSKLMERELNPYWKDGGTGLPPEDCSVSSITKVSVVEDGGLSWLRKSYLRMKEQAEKQSRNFE
DIVAERYGSMEIFQSKLEDAEKAASTKEDYRRERWRKPTYSDKAQNCQESRESDLVKYGNSSRDRYATTDTAKNSNNEKFIGDEKDKRPG
SLETCRRESNPRQNQEFSFGNLRAKFLRPSDDEELSFHSKGRKFEPLSSSSALVAQGSLCSGFRKPTKNSEERLTSWSRSDGRGDKKHSN
QKPSETSTDEHQHVPEDPREKSQDEVLRDDPPKKEHLRDTKSTFAGSPERESIHILSVDEKNKLGAKIIKAEMMGNMELAEQLKVQLEKA
NKFKETITQIPKKSGVENEDQQEVILVRTDQSGRVWPVNTPGKSLESQGGRRKRQMVSTHEERERVRYFHDDDNLSLNDLVKNEKMGTAE
NQNKLFMRMASKFMGKTDGDYYTLDDMFVSKAAERERLGEEEENQRKKAIAEHRSLAAQMEKCLYCFDSSQFPKHLIVAIGVKVYLCLPN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP32-CWF19L2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ARHGAP32	chr11:128932175	chr11:107326502	ENST00000310343	-	9	22	1685_2087	307.0	2088.0	FYN
Hgene	ARHGAP32	chr11:128932175	chr11:107326502	ENST00000392657	-	1	13	1685_2087	0	1739.0	FYN
Hgene	ARHGAP32	chr11:128932175	chr11:107326502	ENST00000527272	-	1	12	1685_2087	0	1739.0	FYN
Hgene	ARHGAP32	chr11:128932175	chr11:107326502	ENST00000310343	-	9	22	1391_1711	307.0	2088.0	GAB2
Hgene	ARHGAP32	chr11:128932175	chr11:107326502	ENST00000392657	-	1	13	1391_1711	0	1739.0	GAB2
Hgene	ARHGAP32	chr11:128932175	chr11:107326502	ENST00000527272	-	1	12	1391_1711	0	1739.0	GAB2

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ARHGAP32-CWF19L2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARHGAP32-CWF19L2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ARHGAP32	C0036341	Schizophrenia	1	PSYGENET