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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:PACS2-DSG2 (FusionGDB2 ID:61872) |
Fusion Gene Summary for PACS2-DSG2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PACS2-DSG2 | Fusion gene ID: 61872 | Hgene | Tgene | Gene symbol | PACS2 | DSG2 | Gene ID | 23241 | 1829 |
Gene name | phosphofurin acidic cluster sorting protein 2 | desmoglein 2 | |
Synonyms | EIEE66|PACS-2|PACS1L | CDHF5|HDGC | |
Cytomap | 14q32.33 | 18q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphofurin acidic cluster sorting protein 2PACS1-like protein | desmoglein-2cadherin family member 5 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | Q14126 | |
Ensembl transtripts involved in fusion gene | ENST00000430725, ENST00000325438, ENST00000458164, ENST00000447393, ENST00000547217, ENST00000551743, ENST00000551801, | ENST00000261590, ENST00000585206, | |
Fusion gene scores | * DoF score | 13 X 12 X 6=936 | 5 X 4 X 2=40 |
# samples | 14 | 5 | |
** MAII score | log2(14/936*10)=-2.74108170263844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PACS2 [Title/Abstract] AND DSG2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | PACS2(105818804)-DSG2(29104666), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PACS2 | GO:0000045 | autophagosome assembly | 23455425 |
Hgene | PACS2 | GO:0034497 | protein localization to phagophore assembly site | 23455425 |
Tgene | DSG2 | GO:0007155 | cell adhesion | 17559062 |
Tgene | DSG2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 17559062 |
Fusion gene breakpoints across PACS2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across DSG2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | UCS | TCGA-N5-A4RD-01A | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
ChimerDB4 | UCS | TCGA-N5-A4RD | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
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Fusion Gene ORF analysis for PACS2-DSG2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000430725 | ENST00000261590 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
5CDS-intron | ENST00000430725 | ENST00000585206 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
In-frame | ENST00000325438 | ENST00000261590 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
5CDS-intron | ENST00000325438 | ENST00000585206 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
In-frame | ENST00000458164 | ENST00000261590 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
5CDS-intron | ENST00000458164 | ENST00000585206 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
In-frame | ENST00000447393 | ENST00000261590 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
5CDS-intron | ENST00000447393 | ENST00000585206 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
intron-3CDS | ENST00000547217 | ENST00000261590 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
intron-intron | ENST00000547217 | ENST00000585206 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
intron-3CDS | ENST00000551743 | ENST00000261590 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
intron-intron | ENST00000551743 | ENST00000585206 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
intron-3CDS | ENST00000551801 | ENST00000261590 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
intron-intron | ENST00000551801 | ENST00000585206 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000430725 | PACS2 | chr14 | 105818804 | + | ENST00000261590 | DSG2 | chr18 | 29104666 | + | 5389 | 595 | 304 | 3123 | 939 |
ENST00000325438 | PACS2 | chr14 | 105818804 | + | ENST00000261590 | DSG2 | chr18 | 29104666 | + | 5595 | 801 | 177 | 3329 | 1050 |
ENST00000458164 | PACS2 | chr14 | 105818804 | + | ENST00000261590 | DSG2 | chr18 | 29104666 | + | 5266 | 472 | 175 | 3000 | 941 |
ENST00000447393 | PACS2 | chr14 | 105818804 | + | ENST00000261590 | DSG2 | chr18 | 29104666 | + | 5266 | 472 | 175 | 3000 | 941 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000430725 | ENST00000261590 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + | 0.000224686 | 0.99977535 |
ENST00000325438 | ENST00000261590 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + | 0.000263799 | 0.99973625 |
ENST00000458164 | ENST00000261590 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + | 0.000287464 | 0.9997125 |
ENST00000447393 | ENST00000261590 | PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104666 | + | 0.000287464 | 0.9997125 |
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Fusion Genomic Features for PACS2-DSG2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104665 | + | 0.3828065 | 0.6171935 |
PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104665 | + | 0.3828065 | 0.6171935 |
PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104665 | + | 0.3828065 | 0.6171935 |
PACS2 | chr14 | 105818804 | + | DSG2 | chr18 | 29104665 | + | 0.3828065 | 0.6171935 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PACS2-DSG2 |
Go to FGviewer for the breakpoints of chr14:105818804-chr18:29104666 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | DSG2 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 274_388 | 276.0 | 1119.0 | Domain | Cadherin 3 | |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 389_503 | 276.0 | 1119.0 | Domain | Cadherin 4 | |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 1022_1051 | 276.0 | 1119.0 | Repeat | Note=Desmoglein repeat 6 | |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 881_912 | 276.0 | 1119.0 | Repeat | Note=Desmoglein repeat 1 | |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 913_942 | 276.0 | 1119.0 | Repeat | Note=Desmoglein repeat 2 | |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 943_968 | 276.0 | 1119.0 | Repeat | Note=Desmoglein repeat 3 | |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 969_992 | 276.0 | 1119.0 | Repeat | Note=Desmoglein repeat 4 | |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 993_1021 | 276.0 | 1119.0 | Repeat | Note=Desmoglein repeat 5 | |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 635_1118 | 276.0 | 1119.0 | Topological domain | Cytoplasmic | |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 610_634 | 276.0 | 1119.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 161_273 | 276.0 | 1119.0 | Domain | Cadherin 2 | |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 50_160 | 276.0 | 1119.0 | Domain | Cadherin 1 | |
Tgene | DSG2 | chr14:105818804 | chr18:29104666 | ENST00000261590 | 6 | 15 | 50_609 | 276.0 | 1119.0 | Topological domain | Extracellular |
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Fusion Gene Sequence for PACS2-DSG2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000430725_ENST00000261590_TCGA-N5-A4RD-01A_PACS2_chr14_105818804_+_DSG2_chr18_29104666_length(transcript)=5389nt_BP=595nt CGTCCCCGCGCGCCGCGTCCAGCTCGATGTCCGTGCCGCCGCAACCGCGGCACACGCGGCCCGTCATGCCGGCGACCGCGCGGGCAGCGC CCGGAGCCTCCCAAGACTCTCAAGCCACCCGAGCCTCCGGAGCAGCCCGCGCCGCCCGCCCAGGCCCAGCCGCCCAGGCCTCGCCGCTCT CGCGAGGCCCCGCTCCAGCCGATTCGCAGCCGCAGATTCGCCGCGCGCGCCCGGGCCGCGCCGCCCGCAACGGCCGCGCCCGCGGGATGG GACAGGCACCGGGACCACGGCGGGGACGCGAGGACTGGAGCCGCGACCTCCCCACTGCGAGCGAGCTGGCCTCCCTTGCGGCGCGCCGGC GTCGGAGGGGCGACCTGCGGGGGCTGGGCTTCGGCGGAACCCGAGCGGGGCCTACCGGTTGTGCAGCCTGACTCTGAAGAAGCTGGTGGT CTTCAAGGAGCTGGAGAAGGAGCTGATCTCCGTGGTGATCGCTGTCAAGATGCAGGGCTCCAAACGAATCCTGCGGTCCCATGAGATTGT GCTGCCCCCCAGTGGACAAGTGGAGACAGACCTGGCCCTGACCTTCTCCTTGCAGCTTGAAGGGATGGTTGAAGAAAATCAAGTCAACGT AGAAGTTACGCGCATAAAAGTGTTCGATGCAGATGAAATAGGTTCTGATAATTGGCTGGCAAATTTTACATTTGCATCAGGAAATGAAGG AGGTTATTTCCACATAGAAACAGATGCTCAAACTAACGAAGGAATTGTGACCCTTATTAAGGAAGTAGATTATGAAGAAATGAAGAATCT TGACTTCAGTGTTATTGTCGCTAATAAAGCAGCTTTTCACAAGTCGATTAGGAGTAAATACAAGCCTACACCCATTCCCATCAAGGTCAA AGTGAAAAATGTGAAAGAAGGCATTCATTTTAAAAGCAGCGTCATCTCAATTTATGTTAGCGAGAGCATGGATAGATCAAGCAAAGGCCA AATAATTGGAAATTTTCAAGCTTTTGATGAGGACACTGGACTACCAGCCCATGCAAGATATGTAAAATTAGAAGATAGAGATAATTGGAT CTCTGTGGATTCTGTCACATCTGAAATTAAACTTGCAAAACTTCCTGATTTTGAATCTAGATATGTTCAAAATGGCACATACACTGTAAA GATTGTGGCCATATCAGAAGATTATCCTAGAAAAACCATCACTGGCACAGTCCTTATCAATGTTGAAGACATCAACGACAACTGTCCCAC ACTGATAGAGCCTGTGCAGACAATCTGTCACGATGCAGAGTATGTGAATGTTACTGCAGAGGACCTGGATGGACACCCAAACAGTGGCCC TTTCAGTTTCTCCGTCATTGACAAACCACCTGGCATGGCAGAAAAATGGAAAATAGCACGCCAAGAAAGTACCAGTGTGCTGCTGCAACA AAGTGAGAAAAAGCTTGGGAGAAGTGAAATTCAGTTCCTGATTTCAGACAATCAGGGTTTTAGTTGTCCTGAAAAGCAGGTCCTTACACT CACAGTTTGTGAGTGTCTGCATGGCAGCGGCTGCAGGGAAGCACAGCATGACTCCTATGTGGGCCTGGGACCCGCAGCAATTGCGCTCAT GATTTTGGCCTTTCTGCTCCTGCTATTGGTACCACTTTTACTGCTGATGTGCCATTGCGGAAAGGGCGCCAAAGGCTTTACCCCCATACC TGGCACCATAGAGATGCTGCATCCTTGGAATAATGAAGGAGCACCACCTGAAGACAAGGTGGTGCCATCATTTCTGCCAGTGGATCAAGG GGGCAGTCTAGTAGGAAGAAATGGAGTAGGAGGTATGGCCAAGGAAGCCACGATGAAAGGAAGTAGCTCTGCTTCCATTGTCAAAGGGCA ACATGAGATGTCCGAGATGGATGGAAGGTGGGAAGAACACAGAAGCCTGCTTTCTGGTAGAGCTACCCAGTTTACAGGGGCCACAGGCGC TATCATGACCACTGAAACCACGAAGACCGCAAGGGCCACAGGGGCTTCCAGAGACATGGCCGGAGCTCAGGCAGCTGCTGTTGCACTGAA CGAAGAATTCTTAAGAAATTATTTCACTGATAAAGCGGCCTCTTACACTGAGGAAGATGAAAATCACACAGCCAAAGATTGCCTTCTGGT TTATTCTCAGGAAGAAACTGAATCGCTGAATGCTTCTATTGGTTGTTGCAGTTTTATTGAAGGAGAGCTAGATGACCGCTTCTTAGATGA TTTGGGACTTAAATTCAAGACACTAGCTGAAGTTTGCCTGGGTCAAAAAATAGATATAAATAAGGAAATTGAGCAGAGACAAAAACCTGC CACAGAAACAAGTATGAACACAGCTTCACATTCACTCTGTGAGCAAACTATGGTTAATTCAGAGAATACCTACTCCTCTGGCAGTAGCTT CCCAGTTCCAAAATCTTTGCAAGAAGCCAATGCAGAGAAAGTAACTCAGGAAATAGTCACTGAAAGATCTGTGTCTTCTAGGCAGGCGCA AAAGGTAGCTACACCTCTTCCTGACCCAATGGCTTCTAGAAATGTGATAGCAACAGAAACTTCCTATGTCACAGGGTCCACTATGCCACC AACCACTGTGATCCTGGGTCCTAGCCAGCCACAGAGCCTTATTGTGACAGAGAGGGTGTATGCTCCAGCTTCTACCTTGGTAGATCAGCC TTATGCTAATGAAGGTACAGTTGTGGTCACTGAAAGAGTAATACAGCCTCATGGGGGTGGATCGAATCCTCTGGAAGGCACTCAGCATCT TCAAGATGTACCTTACGTCATGGTGAGGGAAAGAGAGAGCTTCCTTGCCCCCAGCTCAGGTGTGCAGCCTACTCTGGCCATGCCTAATAT AGCAGTAGGACAGAATGTGACAGTGACAGAAAGAGTTCTAGCACCTGCTTCCACTCTGCAATCCAGTTACCAGATTCCCACTGAAAATTC TATGACGGCTAGGAACACCACGGTGTCTGGAGCTGGAGTCCCTGGCCCTCTGCCAGATTTTGGTTTAGAGGAATCTGGTCATTCTAATTC TACCATAACCACATCTTCCACCAGAGTTACCAAGCATAGCACTGTACAGCATTCTTACTCCTAAACAGCAGTCAGCCACAAACTGACCCA GAGTTTAATTAGCAGTGACTAATTTCATGTTTCCAATGTACCTGATTTTTCATGAGCCTTACAGACACACAGAGACACATACACATTGAT CTTAAAATTTTTCTCAGTCACTGATATGCAAAGGACCACACTGTCTCTGCTTCCAGGAGTATTTTAGAAATGTTCCACAATTTACTGAAG ACATAGAGATGATGCTGCTGCTTAGGTGCCTTTTAGCAAGCTATGCAAACAATCCTGATAAAACAAGATACATAGAGAGTCAATCTGGCT TCTGAGAATTTACCAAGTGAACAGAGTACCTAGTTCATCAGCCGTCCAGTAAAGCAACCCAGGAAACTGACTGGGTCTCTTTGCCTACCG TATTAACATTAAACATTGATGTTCTGTATTCTGTACTTTACTGCACCCAGCAGACTTTCAACAACTCATTGATCCAAAGATACATGCACA GTCTGAGCACCAGCTATGGTGCTCATAACTTCTTTAAGACTTGAACCCTTTCAATCTGTGTGATTCATTAAATTGGACCATTGATGATAA GAATACACATTGTATGTTTCTGTGCACATGACAGTGTGTGTGTGTGCACGTACATACTGTATAGTCTTAAAAATAGCATTATACTGGCCA GGGGTGGTGGCTAACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCAACTGTGGTCAGGAGTTTGAGATCAGCCAGGCC AACCTGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGATGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGA GGCAGGAGAATCACTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAGTCTGGGCAACAGAGTGAGATT CCGTCTCAAAAAAAAAAAGAAAAGGAAAAAAAAATAGCATTATACCTCTTCCTTGTCTCAACCGCCATGAAAATTCTGAACACTCCAAAT TCAGTTGAATAATCCAAAACAAAATTTATAAGTATAAAATAATTTTACTTCTTATAGTAATAGTATACTTTAAAAAGCCTCAGGGTATAT TATCTTCTAAACAGCTACAATTCAGTGCAGCTACATTAACCAACTATGTTCTCTAGTTGAGAACAACTAGGCCTATTTCACTGCTGTGTA GCCTCAGTGCCTAACATGGGTGCCAAATAAATATTCGTAGAATTACACTGAATTGTAAAAACCATTCGTTTTTGTTTACAATTGCCAAAA ATCTCAAAAGGCCCTGTATTTATGTAATTCTTTGAAATTATTATTTTATTTTGATTTCTCAGTTATTGACTGGCTGGGTGTGACTTAGTA CATAAGTACTCAATATTATAAAAACCTCAAATAATTGACTTGATTTTACACAACATCCTTCCCTTTTCTACAAGTTAATTTTTTTACAAA TCATTTGGGTTATCTCCTAAATAGGTTATATTTTATTGCTTCTAGAAACAATGTTTCAAAATATATGTGCATTATCAGTAATAATTTGTA TAAATATTTCCCACAACAATTTTCATAATTTTCAAAGACTAATTTCTTGACTGAAGATATTTTGCTAGGGAAGTGAAACTTTAAAATTTT GTAGATTTTAAAAAATATTGTTGAATGGTGTCATGCAAAGGATTTATATAGTGTGCTCCCACTAACTGTACAGATCAGGACACATATTTT TAGACATCTAAGTCTGTAGCTTAAATGGAGGTTACTCTTCCATCATCTAGAATTGTTTACTTAGTAATTGTTGTTTCTTTTATTATTATA GACTTACTATCAGTTTTATTTTGCCAAGTATGCAACAGGTATATCACTAGTATATGAAAATGTAAATATCACTTGTGTACTCAAACAAAA GTTGGTCTTAAGCTTCCACCTTGAGCAGCCTTGGAAACCTAACCTGCCTCTTTTAGCATAATCACATTTTCTAAATGATTTTCTTTGTTC CTGAAAAAGTGATTTGTATTAGTTTTACATTTGTTTTTTGGAAGATTATATTTGTATATGTATCATCATAAAATATTTAAATAAAAAGTA TCTTTAGAGTGACCCTTTCCCCATAGATTTTTATTTCTCTATTATATTTTACAAGGAATATAACTCAGTTTGTTAGGGAGAGTGCCTTAA >In-frame_ENST00000430725_ENST00000261590_TCGA-N5-A4RD-01A_PACS2_chr14_105818804_+_DSG2_chr18_29104666_length(amino acids)=939AA_start in transcript=304_stop in transcript=3123 MEPRPPHCERAGLPCGAPASEGRPAGAGLRRNPSGAYRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVETDL ALTFSLQLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAA FHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKL AKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPG MAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVP LLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWE EHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNA SIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANA EKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVVTE RVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGA -------------------------------------------------------------- >In-frame_ENST00000325438_ENST00000261590_TCGA-N5-A4RD-01A_PACS2_chr14_105818804_+_DSG2_chr18_29104666_length(transcript)=5595nt_BP=801nt GGTGGACCCCCACGACTCTCCCGGCCCTTGCCCGCGGCTCCCGGGGGGCGGGGCGGGGCGCCCCGGGCGGGGTCTGTGCGCAGGCGCGTG AGTGCGCGCTCTCGCGCACCGGCGGGCGGGGACGCCCCGTGAGGCGCCGCCGGAGGAAGCGCGCGCGCACCTCACTTCCGGCGCGCGCTG CGCCGGCGGCGATTGGACCCGAGGCGGCGAGCTGGCGCCCCGCCCAGCCAATCGGCGGCGCCGGCGCGGGTCGGAGGGCGCCGGGCGCGC GCGGGGCGGCCGGGGGCGCGCGGGGCGCGGGCGGGGCGCCGGGCGGGGCGGGGCGGAGCGGCCGCAGCTCGTCGCCGCCCGCGGGCCTGT CCGACGCCGGGGCCCGGCCCGTCCCCTCCGCCGCCCGGCAGCCATGTGACCGCGCCGCCGCCCTCCGCGCGCCCGGCCCGCCCGCCGCGC GTCCGCGGCCCGGCCGCAGCCCCAGGCCGCCGAGGGAGCGGCGGGGCCGGCGCCATGGCCGAGCGAGGCCGCCTCGGCCTCCCCGGCGCG CCCGGCGCGCTCAACACGCCCGTGCCCATGAACCTGTTCGCCACCTGGGAGGTGGACGGCTCCAGCCCCAGCTGCGTGCCCAGGTTGTGC AGCCTGACTCTGAAGAAGCTGGTGGTCTTCAAGGAGCTGGAGAAGGAGCTGATCTCCGTGGTGATCGCTGTCAAGATGCAGGGCTCCAAA CGAATCCTGCGGTCCCATGAGATTGTGCTGCCCCCCAGTGGACAAGTGGAGACAGACCTGGCCCTGACCTTCTCCTTGCAGCTTGAAGGG ATGGTTGAAGAAAATCAAGTCAACGTAGAAGTTACGCGCATAAAAGTGTTCGATGCAGATGAAATAGGTTCTGATAATTGGCTGGCAAAT TTTACATTTGCATCAGGAAATGAAGGAGGTTATTTCCACATAGAAACAGATGCTCAAACTAACGAAGGAATTGTGACCCTTATTAAGGAA GTAGATTATGAAGAAATGAAGAATCTTGACTTCAGTGTTATTGTCGCTAATAAAGCAGCTTTTCACAAGTCGATTAGGAGTAAATACAAG CCTACACCCATTCCCATCAAGGTCAAAGTGAAAAATGTGAAAGAAGGCATTCATTTTAAAAGCAGCGTCATCTCAATTTATGTTAGCGAG AGCATGGATAGATCAAGCAAAGGCCAAATAATTGGAAATTTTCAAGCTTTTGATGAGGACACTGGACTACCAGCCCATGCAAGATATGTA AAATTAGAAGATAGAGATAATTGGATCTCTGTGGATTCTGTCACATCTGAAATTAAACTTGCAAAACTTCCTGATTTTGAATCTAGATAT GTTCAAAATGGCACATACACTGTAAAGATTGTGGCCATATCAGAAGATTATCCTAGAAAAACCATCACTGGCACAGTCCTTATCAATGTT GAAGACATCAACGACAACTGTCCCACACTGATAGAGCCTGTGCAGACAATCTGTCACGATGCAGAGTATGTGAATGTTACTGCAGAGGAC CTGGATGGACACCCAAACAGTGGCCCTTTCAGTTTCTCCGTCATTGACAAACCACCTGGCATGGCAGAAAAATGGAAAATAGCACGCCAA GAAAGTACCAGTGTGCTGCTGCAACAAAGTGAGAAAAAGCTTGGGAGAAGTGAAATTCAGTTCCTGATTTCAGACAATCAGGGTTTTAGT TGTCCTGAAAAGCAGGTCCTTACACTCACAGTTTGTGAGTGTCTGCATGGCAGCGGCTGCAGGGAAGCACAGCATGACTCCTATGTGGGC CTGGGACCCGCAGCAATTGCGCTCATGATTTTGGCCTTTCTGCTCCTGCTATTGGTACCACTTTTACTGCTGATGTGCCATTGCGGAAAG GGCGCCAAAGGCTTTACCCCCATACCTGGCACCATAGAGATGCTGCATCCTTGGAATAATGAAGGAGCACCACCTGAAGACAAGGTGGTG CCATCATTTCTGCCAGTGGATCAAGGGGGCAGTCTAGTAGGAAGAAATGGAGTAGGAGGTATGGCCAAGGAAGCCACGATGAAAGGAAGT AGCTCTGCTTCCATTGTCAAAGGGCAACATGAGATGTCCGAGATGGATGGAAGGTGGGAAGAACACAGAAGCCTGCTTTCTGGTAGAGCT ACCCAGTTTACAGGGGCCACAGGCGCTATCATGACCACTGAAACCACGAAGACCGCAAGGGCCACAGGGGCTTCCAGAGACATGGCCGGA GCTCAGGCAGCTGCTGTTGCACTGAACGAAGAATTCTTAAGAAATTATTTCACTGATAAAGCGGCCTCTTACACTGAGGAAGATGAAAAT CACACAGCCAAAGATTGCCTTCTGGTTTATTCTCAGGAAGAAACTGAATCGCTGAATGCTTCTATTGGTTGTTGCAGTTTTATTGAAGGA GAGCTAGATGACCGCTTCTTAGATGATTTGGGACTTAAATTCAAGACACTAGCTGAAGTTTGCCTGGGTCAAAAAATAGATATAAATAAG GAAATTGAGCAGAGACAAAAACCTGCCACAGAAACAAGTATGAACACAGCTTCACATTCACTCTGTGAGCAAACTATGGTTAATTCAGAG AATACCTACTCCTCTGGCAGTAGCTTCCCAGTTCCAAAATCTTTGCAAGAAGCCAATGCAGAGAAAGTAACTCAGGAAATAGTCACTGAA AGATCTGTGTCTTCTAGGCAGGCGCAAAAGGTAGCTACACCTCTTCCTGACCCAATGGCTTCTAGAAATGTGATAGCAACAGAAACTTCC TATGTCACAGGGTCCACTATGCCACCAACCACTGTGATCCTGGGTCCTAGCCAGCCACAGAGCCTTATTGTGACAGAGAGGGTGTATGCT CCAGCTTCTACCTTGGTAGATCAGCCTTATGCTAATGAAGGTACAGTTGTGGTCACTGAAAGAGTAATACAGCCTCATGGGGGTGGATCG AATCCTCTGGAAGGCACTCAGCATCTTCAAGATGTACCTTACGTCATGGTGAGGGAAAGAGAGAGCTTCCTTGCCCCCAGCTCAGGTGTG CAGCCTACTCTGGCCATGCCTAATATAGCAGTAGGACAGAATGTGACAGTGACAGAAAGAGTTCTAGCACCTGCTTCCACTCTGCAATCC AGTTACCAGATTCCCACTGAAAATTCTATGACGGCTAGGAACACCACGGTGTCTGGAGCTGGAGTCCCTGGCCCTCTGCCAGATTTTGGT TTAGAGGAATCTGGTCATTCTAATTCTACCATAACCACATCTTCCACCAGAGTTACCAAGCATAGCACTGTACAGCATTCTTACTCCTAA ACAGCAGTCAGCCACAAACTGACCCAGAGTTTAATTAGCAGTGACTAATTTCATGTTTCCAATGTACCTGATTTTTCATGAGCCTTACAG ACACACAGAGACACATACACATTGATCTTAAAATTTTTCTCAGTCACTGATATGCAAAGGACCACACTGTCTCTGCTTCCAGGAGTATTT TAGAAATGTTCCACAATTTACTGAAGACATAGAGATGATGCTGCTGCTTAGGTGCCTTTTAGCAAGCTATGCAAACAATCCTGATAAAAC AAGATACATAGAGAGTCAATCTGGCTTCTGAGAATTTACCAAGTGAACAGAGTACCTAGTTCATCAGCCGTCCAGTAAAGCAACCCAGGA AACTGACTGGGTCTCTTTGCCTACCGTATTAACATTAAACATTGATGTTCTGTATTCTGTACTTTACTGCACCCAGCAGACTTTCAACAA CTCATTGATCCAAAGATACATGCACAGTCTGAGCACCAGCTATGGTGCTCATAACTTCTTTAAGACTTGAACCCTTTCAATCTGTGTGAT TCATTAAATTGGACCATTGATGATAAGAATACACATTGTATGTTTCTGTGCACATGACAGTGTGTGTGTGTGCACGTACATACTGTATAG TCTTAAAAATAGCATTATACTGGCCAGGGGTGGTGGCTAACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCAACTGTG GTCAGGAGTTTGAGATCAGCCAGGCCAACCTGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGATGGTGGGCGCCT GTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCACCATTGCAC TCCAGTCTGGGCAACAGAGTGAGATTCCGTCTCAAAAAAAAAAAGAAAAGGAAAAAAAAATAGCATTATACCTCTTCCTTGTCTCAACCG CCATGAAAATTCTGAACACTCCAAATTCAGTTGAATAATCCAAAACAAAATTTATAAGTATAAAATAATTTTACTTCTTATAGTAATAGT ATACTTTAAAAAGCCTCAGGGTATATTATCTTCTAAACAGCTACAATTCAGTGCAGCTACATTAACCAACTATGTTCTCTAGTTGAGAAC AACTAGGCCTATTTCACTGCTGTGTAGCCTCAGTGCCTAACATGGGTGCCAAATAAATATTCGTAGAATTACACTGAATTGTAAAAACCA TTCGTTTTTGTTTACAATTGCCAAAAATCTCAAAAGGCCCTGTATTTATGTAATTCTTTGAAATTATTATTTTATTTTGATTTCTCAGTT ATTGACTGGCTGGGTGTGACTTAGTACATAAGTACTCAATATTATAAAAACCTCAAATAATTGACTTGATTTTACACAACATCCTTCCCT TTTCTACAAGTTAATTTTTTTACAAATCATTTGGGTTATCTCCTAAATAGGTTATATTTTATTGCTTCTAGAAACAATGTTTCAAAATAT ATGTGCATTATCAGTAATAATTTGTATAAATATTTCCCACAACAATTTTCATAATTTTCAAAGACTAATTTCTTGACTGAAGATATTTTG CTAGGGAAGTGAAACTTTAAAATTTTGTAGATTTTAAAAAATATTGTTGAATGGTGTCATGCAAAGGATTTATATAGTGTGCTCCCACTA ACTGTACAGATCAGGACACATATTTTTAGACATCTAAGTCTGTAGCTTAAATGGAGGTTACTCTTCCATCATCTAGAATTGTTTACTTAG TAATTGTTGTTTCTTTTATTATTATAGACTTACTATCAGTTTTATTTTGCCAAGTATGCAACAGGTATATCACTAGTATATGAAAATGTA AATATCACTTGTGTACTCAAACAAAAGTTGGTCTTAAGCTTCCACCTTGAGCAGCCTTGGAAACCTAACCTGCCTCTTTTAGCATAATCA CATTTTCTAAATGATTTTCTTTGTTCCTGAAAAAGTGATTTGTATTAGTTTTACATTTGTTTTTTGGAAGATTATATTTGTATATGTATC ATCATAAAATATTTAAATAAAAAGTATCTTTAGAGTGACCCTTTCCCCATAGATTTTTATTTCTCTATTATATTTTACAAGGAATATAAC TCAGTTTGTTAGGGAGAGTGCCTTAAAGGCAGGTGTTTCTTGGACTTTGTTATTTAATTAGATCTGCTTGCAATAAAAAAAGTTGTCGGT >In-frame_ENST00000325438_ENST00000261590_TCGA-N5-A4RD-01A_PACS2_chr14_105818804_+_DSG2_chr18_29104666_length(amino acids)=1050AA_start in transcript=177_stop in transcript=3329 MRRRRLDPRRRAGAPPSQSAAPARVGGRRARAGRPGARGARAGRRAGRGGAAAARRRPRACPTPGPGPSPPPPGSHVTAPPPSARPARPP RVRGPAAAPGRRGSGGAGAMAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGS KRILRSHEIVLPPSGQVETDLALTFSLQLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIK EVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARY VKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAE DLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYV GLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKG SSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDE NHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNS ENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVY APASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQ -------------------------------------------------------------- >In-frame_ENST00000458164_ENST00000261590_TCGA-N5-A4RD-01A_PACS2_chr14_105818804_+_DSG2_chr18_29104666_length(transcript)=5266nt_BP=472nt GGCCGCAGCTCGTCGCCGCCCGCGGGCCTGTCCGACGCCGGGGCCCGGCCCGTCCCCTCCGCCGCCCGGCAGCCATGTGACCGCGCCGCC GCCCTCCGCGCGCCCGGCCCGCCCGCCGCGCGTCCGCGGCCCGGCCGCAGCCCCAGGCCGCCGAGGGAGCGGCGGGGCCGGCGCCATGGC CGAGCGAGGCCGCCTCGGCCTCCCCGGCGCGCCCGGCGCGCTCAACACGCCCGTGCCCATGAACCTGTTCGCCACCTGGGAGGTGGACGG CTCCAGCCCCAGCTGCGTGCCCAGGTTGTGCAGCCTGACTCTGAAGAAGCTGGTGGTCTTCAAGGAGCTGGAGAAGGAGCTGATCTCCGT GGTGATCGCTGTCAAGATGCAGGGCTCCAAACGAATCCTGCGGTCCCATGAGATTGTGCTGCCCCCCAGTGGACAAGTGGAGACAGACCT GGCCCTGACCTTCTCCTTGCAGCTTGAAGGGATGGTTGAAGAAAATCAAGTCAACGTAGAAGTTACGCGCATAAAAGTGTTCGATGCAGA TGAAATAGGTTCTGATAATTGGCTGGCAAATTTTACATTTGCATCAGGAAATGAAGGAGGTTATTTCCACATAGAAACAGATGCTCAAAC TAACGAAGGAATTGTGACCCTTATTAAGGAAGTAGATTATGAAGAAATGAAGAATCTTGACTTCAGTGTTATTGTCGCTAATAAAGCAGC TTTTCACAAGTCGATTAGGAGTAAATACAAGCCTACACCCATTCCCATCAAGGTCAAAGTGAAAAATGTGAAAGAAGGCATTCATTTTAA AAGCAGCGTCATCTCAATTTATGTTAGCGAGAGCATGGATAGATCAAGCAAAGGCCAAATAATTGGAAATTTTCAAGCTTTTGATGAGGA CACTGGACTACCAGCCCATGCAAGATATGTAAAATTAGAAGATAGAGATAATTGGATCTCTGTGGATTCTGTCACATCTGAAATTAAACT TGCAAAACTTCCTGATTTTGAATCTAGATATGTTCAAAATGGCACATACACTGTAAAGATTGTGGCCATATCAGAAGATTATCCTAGAAA AACCATCACTGGCACAGTCCTTATCAATGTTGAAGACATCAACGACAACTGTCCCACACTGATAGAGCCTGTGCAGACAATCTGTCACGA TGCAGAGTATGTGAATGTTACTGCAGAGGACCTGGATGGACACCCAAACAGTGGCCCTTTCAGTTTCTCCGTCATTGACAAACCACCTGG CATGGCAGAAAAATGGAAAATAGCACGCCAAGAAAGTACCAGTGTGCTGCTGCAACAAAGTGAGAAAAAGCTTGGGAGAAGTGAAATTCA GTTCCTGATTTCAGACAATCAGGGTTTTAGTTGTCCTGAAAAGCAGGTCCTTACACTCACAGTTTGTGAGTGTCTGCATGGCAGCGGCTG CAGGGAAGCACAGCATGACTCCTATGTGGGCCTGGGACCCGCAGCAATTGCGCTCATGATTTTGGCCTTTCTGCTCCTGCTATTGGTACC ACTTTTACTGCTGATGTGCCATTGCGGAAAGGGCGCCAAAGGCTTTACCCCCATACCTGGCACCATAGAGATGCTGCATCCTTGGAATAA TGAAGGAGCACCACCTGAAGACAAGGTGGTGCCATCATTTCTGCCAGTGGATCAAGGGGGCAGTCTAGTAGGAAGAAATGGAGTAGGAGG TATGGCCAAGGAAGCCACGATGAAAGGAAGTAGCTCTGCTTCCATTGTCAAAGGGCAACATGAGATGTCCGAGATGGATGGAAGGTGGGA AGAACACAGAAGCCTGCTTTCTGGTAGAGCTACCCAGTTTACAGGGGCCACAGGCGCTATCATGACCACTGAAACCACGAAGACCGCAAG GGCCACAGGGGCTTCCAGAGACATGGCCGGAGCTCAGGCAGCTGCTGTTGCACTGAACGAAGAATTCTTAAGAAATTATTTCACTGATAA AGCGGCCTCTTACACTGAGGAAGATGAAAATCACACAGCCAAAGATTGCCTTCTGGTTTATTCTCAGGAAGAAACTGAATCGCTGAATGC TTCTATTGGTTGTTGCAGTTTTATTGAAGGAGAGCTAGATGACCGCTTCTTAGATGATTTGGGACTTAAATTCAAGACACTAGCTGAAGT TTGCCTGGGTCAAAAAATAGATATAAATAAGGAAATTGAGCAGAGACAAAAACCTGCCACAGAAACAAGTATGAACACAGCTTCACATTC ACTCTGTGAGCAAACTATGGTTAATTCAGAGAATACCTACTCCTCTGGCAGTAGCTTCCCAGTTCCAAAATCTTTGCAAGAAGCCAATGC AGAGAAAGTAACTCAGGAAATAGTCACTGAAAGATCTGTGTCTTCTAGGCAGGCGCAAAAGGTAGCTACACCTCTTCCTGACCCAATGGC TTCTAGAAATGTGATAGCAACAGAAACTTCCTATGTCACAGGGTCCACTATGCCACCAACCACTGTGATCCTGGGTCCTAGCCAGCCACA GAGCCTTATTGTGACAGAGAGGGTGTATGCTCCAGCTTCTACCTTGGTAGATCAGCCTTATGCTAATGAAGGTACAGTTGTGGTCACTGA AAGAGTAATACAGCCTCATGGGGGTGGATCGAATCCTCTGGAAGGCACTCAGCATCTTCAAGATGTACCTTACGTCATGGTGAGGGAAAG AGAGAGCTTCCTTGCCCCCAGCTCAGGTGTGCAGCCTACTCTGGCCATGCCTAATATAGCAGTAGGACAGAATGTGACAGTGACAGAAAG AGTTCTAGCACCTGCTTCCACTCTGCAATCCAGTTACCAGATTCCCACTGAAAATTCTATGACGGCTAGGAACACCACGGTGTCTGGAGC TGGAGTCCCTGGCCCTCTGCCAGATTTTGGTTTAGAGGAATCTGGTCATTCTAATTCTACCATAACCACATCTTCCACCAGAGTTACCAA GCATAGCACTGTACAGCATTCTTACTCCTAAACAGCAGTCAGCCACAAACTGACCCAGAGTTTAATTAGCAGTGACTAATTTCATGTTTC CAATGTACCTGATTTTTCATGAGCCTTACAGACACACAGAGACACATACACATTGATCTTAAAATTTTTCTCAGTCACTGATATGCAAAG GACCACACTGTCTCTGCTTCCAGGAGTATTTTAGAAATGTTCCACAATTTACTGAAGACATAGAGATGATGCTGCTGCTTAGGTGCCTTT TAGCAAGCTATGCAAACAATCCTGATAAAACAAGATACATAGAGAGTCAATCTGGCTTCTGAGAATTTACCAAGTGAACAGAGTACCTAG TTCATCAGCCGTCCAGTAAAGCAACCCAGGAAACTGACTGGGTCTCTTTGCCTACCGTATTAACATTAAACATTGATGTTCTGTATTCTG TACTTTACTGCACCCAGCAGACTTTCAACAACTCATTGATCCAAAGATACATGCACAGTCTGAGCACCAGCTATGGTGCTCATAACTTCT TTAAGACTTGAACCCTTTCAATCTGTGTGATTCATTAAATTGGACCATTGATGATAAGAATACACATTGTATGTTTCTGTGCACATGACA GTGTGTGTGTGTGCACGTACATACTGTATAGTCTTAAAAATAGCATTATACTGGCCAGGGGTGGTGGCTAACGCCTGTAATCCCAGCACT TTGGGAGGCCGAGGCGGGTGGATCAACTGTGGTCAGGAGTTTGAGATCAGCCAGGCCAACCTGGTGAAACCCCGTCTCTACTAAAAATAC AAAAATTAGCTGGGCGTGATGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAG GTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAGTCTGGGCAACAGAGTGAGATTCCGTCTCAAAAAAAAAAAGAAAAGGAAAAAAAA ATAGCATTATACCTCTTCCTTGTCTCAACCGCCATGAAAATTCTGAACACTCCAAATTCAGTTGAATAATCCAAAACAAAATTTATAAGT ATAAAATAATTTTACTTCTTATAGTAATAGTATACTTTAAAAAGCCTCAGGGTATATTATCTTCTAAACAGCTACAATTCAGTGCAGCTA CATTAACCAACTATGTTCTCTAGTTGAGAACAACTAGGCCTATTTCACTGCTGTGTAGCCTCAGTGCCTAACATGGGTGCCAAATAAATA TTCGTAGAATTACACTGAATTGTAAAAACCATTCGTTTTTGTTTACAATTGCCAAAAATCTCAAAAGGCCCTGTATTTATGTAATTCTTT GAAATTATTATTTTATTTTGATTTCTCAGTTATTGACTGGCTGGGTGTGACTTAGTACATAAGTACTCAATATTATAAAAACCTCAAATA ATTGACTTGATTTTACACAACATCCTTCCCTTTTCTACAAGTTAATTTTTTTACAAATCATTTGGGTTATCTCCTAAATAGGTTATATTT TATTGCTTCTAGAAACAATGTTTCAAAATATATGTGCATTATCAGTAATAATTTGTATAAATATTTCCCACAACAATTTTCATAATTTTC AAAGACTAATTTCTTGACTGAAGATATTTTGCTAGGGAAGTGAAACTTTAAAATTTTGTAGATTTTAAAAAATATTGTTGAATGGTGTCA TGCAAAGGATTTATATAGTGTGCTCCCACTAACTGTACAGATCAGGACACATATTTTTAGACATCTAAGTCTGTAGCTTAAATGGAGGTT ACTCTTCCATCATCTAGAATTGTTTACTTAGTAATTGTTGTTTCTTTTATTATTATAGACTTACTATCAGTTTTATTTTGCCAAGTATGC AACAGGTATATCACTAGTATATGAAAATGTAAATATCACTTGTGTACTCAAACAAAAGTTGGTCTTAAGCTTCCACCTTGAGCAGCCTTG GAAACCTAACCTGCCTCTTTTAGCATAATCACATTTTCTAAATGATTTTCTTTGTTCCTGAAAAAGTGATTTGTATTAGTTTTACATTTG TTTTTTGGAAGATTATATTTGTATATGTATCATCATAAAATATTTAAATAAAAAGTATCTTTAGAGTGACCCTTTCCCCATAGATTTTTA TTTCTCTATTATATTTTACAAGGAATATAACTCAGTTTGTTAGGGAGAGTGCCTTAAAGGCAGGTGTTTCTTGGACTTTGTTATTTAATT >In-frame_ENST00000458164_ENST00000261590_TCGA-N5-A4RD-01A_PACS2_chr14_105818804_+_DSG2_chr18_29104666_length(amino acids)=941AA_start in transcript=175_stop in transcript=3000 MAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVET DLALTFSLQLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANK AAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEI KLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKP PGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLL VPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGR WEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESL NASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEA NAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVV TERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVS -------------------------------------------------------------- >In-frame_ENST00000447393_ENST00000261590_TCGA-N5-A4RD-01A_PACS2_chr14_105818804_+_DSG2_chr18_29104666_length(transcript)=5266nt_BP=472nt GGCCGCAGCTCGTCGCCGCCCGCGGGCCTGTCCGACGCCGGGGCCCGGCCCGTCCCCTCCGCCGCCCGGCAGCCATGTGACCGCGCCGCC GCCCTCCGCGCGCCCGGCCCGCCCGCCGCGCGTCCGCGGCCCGGCCGCAGCCCCAGGCCGCCGAGGGAGCGGCGGGGCCGGCGCCATGGC CGAGCGAGGCCGCCTCGGCCTCCCCGGCGCGCCCGGCGCGCTCAACACGCCCGTGCCCATGAACCTGTTCGCCACCTGGGAGGTGGACGG CTCCAGCCCCAGCTGCGTGCCCAGGTTGTGCAGCCTGACTCTGAAGAAGCTGGTGGTCTTCAAGGAGCTGGAGAAGGAGCTGATCTCCGT GGTGATCGCTGTCAAGATGCAGGGCTCCAAACGAATCCTGCGGTCCCATGAGATTGTGCTGCCCCCCAGTGGACAAGTGGAGACAGACCT GGCCCTGACCTTCTCCTTGCAGCTTGAAGGGATGGTTGAAGAAAATCAAGTCAACGTAGAAGTTACGCGCATAAAAGTGTTCGATGCAGA TGAAATAGGTTCTGATAATTGGCTGGCAAATTTTACATTTGCATCAGGAAATGAAGGAGGTTATTTCCACATAGAAACAGATGCTCAAAC TAACGAAGGAATTGTGACCCTTATTAAGGAAGTAGATTATGAAGAAATGAAGAATCTTGACTTCAGTGTTATTGTCGCTAATAAAGCAGC TTTTCACAAGTCGATTAGGAGTAAATACAAGCCTACACCCATTCCCATCAAGGTCAAAGTGAAAAATGTGAAAGAAGGCATTCATTTTAA AAGCAGCGTCATCTCAATTTATGTTAGCGAGAGCATGGATAGATCAAGCAAAGGCCAAATAATTGGAAATTTTCAAGCTTTTGATGAGGA CACTGGACTACCAGCCCATGCAAGATATGTAAAATTAGAAGATAGAGATAATTGGATCTCTGTGGATTCTGTCACATCTGAAATTAAACT TGCAAAACTTCCTGATTTTGAATCTAGATATGTTCAAAATGGCACATACACTGTAAAGATTGTGGCCATATCAGAAGATTATCCTAGAAA AACCATCACTGGCACAGTCCTTATCAATGTTGAAGACATCAACGACAACTGTCCCACACTGATAGAGCCTGTGCAGACAATCTGTCACGA TGCAGAGTATGTGAATGTTACTGCAGAGGACCTGGATGGACACCCAAACAGTGGCCCTTTCAGTTTCTCCGTCATTGACAAACCACCTGG CATGGCAGAAAAATGGAAAATAGCACGCCAAGAAAGTACCAGTGTGCTGCTGCAACAAAGTGAGAAAAAGCTTGGGAGAAGTGAAATTCA GTTCCTGATTTCAGACAATCAGGGTTTTAGTTGTCCTGAAAAGCAGGTCCTTACACTCACAGTTTGTGAGTGTCTGCATGGCAGCGGCTG CAGGGAAGCACAGCATGACTCCTATGTGGGCCTGGGACCCGCAGCAATTGCGCTCATGATTTTGGCCTTTCTGCTCCTGCTATTGGTACC ACTTTTACTGCTGATGTGCCATTGCGGAAAGGGCGCCAAAGGCTTTACCCCCATACCTGGCACCATAGAGATGCTGCATCCTTGGAATAA TGAAGGAGCACCACCTGAAGACAAGGTGGTGCCATCATTTCTGCCAGTGGATCAAGGGGGCAGTCTAGTAGGAAGAAATGGAGTAGGAGG TATGGCCAAGGAAGCCACGATGAAAGGAAGTAGCTCTGCTTCCATTGTCAAAGGGCAACATGAGATGTCCGAGATGGATGGAAGGTGGGA AGAACACAGAAGCCTGCTTTCTGGTAGAGCTACCCAGTTTACAGGGGCCACAGGCGCTATCATGACCACTGAAACCACGAAGACCGCAAG GGCCACAGGGGCTTCCAGAGACATGGCCGGAGCTCAGGCAGCTGCTGTTGCACTGAACGAAGAATTCTTAAGAAATTATTTCACTGATAA AGCGGCCTCTTACACTGAGGAAGATGAAAATCACACAGCCAAAGATTGCCTTCTGGTTTATTCTCAGGAAGAAACTGAATCGCTGAATGC TTCTATTGGTTGTTGCAGTTTTATTGAAGGAGAGCTAGATGACCGCTTCTTAGATGATTTGGGACTTAAATTCAAGACACTAGCTGAAGT TTGCCTGGGTCAAAAAATAGATATAAATAAGGAAATTGAGCAGAGACAAAAACCTGCCACAGAAACAAGTATGAACACAGCTTCACATTC ACTCTGTGAGCAAACTATGGTTAATTCAGAGAATACCTACTCCTCTGGCAGTAGCTTCCCAGTTCCAAAATCTTTGCAAGAAGCCAATGC AGAGAAAGTAACTCAGGAAATAGTCACTGAAAGATCTGTGTCTTCTAGGCAGGCGCAAAAGGTAGCTACACCTCTTCCTGACCCAATGGC TTCTAGAAATGTGATAGCAACAGAAACTTCCTATGTCACAGGGTCCACTATGCCACCAACCACTGTGATCCTGGGTCCTAGCCAGCCACA GAGCCTTATTGTGACAGAGAGGGTGTATGCTCCAGCTTCTACCTTGGTAGATCAGCCTTATGCTAATGAAGGTACAGTTGTGGTCACTGA AAGAGTAATACAGCCTCATGGGGGTGGATCGAATCCTCTGGAAGGCACTCAGCATCTTCAAGATGTACCTTACGTCATGGTGAGGGAAAG AGAGAGCTTCCTTGCCCCCAGCTCAGGTGTGCAGCCTACTCTGGCCATGCCTAATATAGCAGTAGGACAGAATGTGACAGTGACAGAAAG AGTTCTAGCACCTGCTTCCACTCTGCAATCCAGTTACCAGATTCCCACTGAAAATTCTATGACGGCTAGGAACACCACGGTGTCTGGAGC TGGAGTCCCTGGCCCTCTGCCAGATTTTGGTTTAGAGGAATCTGGTCATTCTAATTCTACCATAACCACATCTTCCACCAGAGTTACCAA GCATAGCACTGTACAGCATTCTTACTCCTAAACAGCAGTCAGCCACAAACTGACCCAGAGTTTAATTAGCAGTGACTAATTTCATGTTTC CAATGTACCTGATTTTTCATGAGCCTTACAGACACACAGAGACACATACACATTGATCTTAAAATTTTTCTCAGTCACTGATATGCAAAG GACCACACTGTCTCTGCTTCCAGGAGTATTTTAGAAATGTTCCACAATTTACTGAAGACATAGAGATGATGCTGCTGCTTAGGTGCCTTT TAGCAAGCTATGCAAACAATCCTGATAAAACAAGATACATAGAGAGTCAATCTGGCTTCTGAGAATTTACCAAGTGAACAGAGTACCTAG TTCATCAGCCGTCCAGTAAAGCAACCCAGGAAACTGACTGGGTCTCTTTGCCTACCGTATTAACATTAAACATTGATGTTCTGTATTCTG TACTTTACTGCACCCAGCAGACTTTCAACAACTCATTGATCCAAAGATACATGCACAGTCTGAGCACCAGCTATGGTGCTCATAACTTCT TTAAGACTTGAACCCTTTCAATCTGTGTGATTCATTAAATTGGACCATTGATGATAAGAATACACATTGTATGTTTCTGTGCACATGACA GTGTGTGTGTGTGCACGTACATACTGTATAGTCTTAAAAATAGCATTATACTGGCCAGGGGTGGTGGCTAACGCCTGTAATCCCAGCACT TTGGGAGGCCGAGGCGGGTGGATCAACTGTGGTCAGGAGTTTGAGATCAGCCAGGCCAACCTGGTGAAACCCCGTCTCTACTAAAAATAC AAAAATTAGCTGGGCGTGATGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAG GTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAGTCTGGGCAACAGAGTGAGATTCCGTCTCAAAAAAAAAAAGAAAAGGAAAAAAAA ATAGCATTATACCTCTTCCTTGTCTCAACCGCCATGAAAATTCTGAACACTCCAAATTCAGTTGAATAATCCAAAACAAAATTTATAAGT ATAAAATAATTTTACTTCTTATAGTAATAGTATACTTTAAAAAGCCTCAGGGTATATTATCTTCTAAACAGCTACAATTCAGTGCAGCTA CATTAACCAACTATGTTCTCTAGTTGAGAACAACTAGGCCTATTTCACTGCTGTGTAGCCTCAGTGCCTAACATGGGTGCCAAATAAATA TTCGTAGAATTACACTGAATTGTAAAAACCATTCGTTTTTGTTTACAATTGCCAAAAATCTCAAAAGGCCCTGTATTTATGTAATTCTTT GAAATTATTATTTTATTTTGATTTCTCAGTTATTGACTGGCTGGGTGTGACTTAGTACATAAGTACTCAATATTATAAAAACCTCAAATA ATTGACTTGATTTTACACAACATCCTTCCCTTTTCTACAAGTTAATTTTTTTACAAATCATTTGGGTTATCTCCTAAATAGGTTATATTT TATTGCTTCTAGAAACAATGTTTCAAAATATATGTGCATTATCAGTAATAATTTGTATAAATATTTCCCACAACAATTTTCATAATTTTC AAAGACTAATTTCTTGACTGAAGATATTTTGCTAGGGAAGTGAAACTTTAAAATTTTGTAGATTTTAAAAAATATTGTTGAATGGTGTCA TGCAAAGGATTTATATAGTGTGCTCCCACTAACTGTACAGATCAGGACACATATTTTTAGACATCTAAGTCTGTAGCTTAAATGGAGGTT ACTCTTCCATCATCTAGAATTGTTTACTTAGTAATTGTTGTTTCTTTTATTATTATAGACTTACTATCAGTTTTATTTTGCCAAGTATGC AACAGGTATATCACTAGTATATGAAAATGTAAATATCACTTGTGTACTCAAACAAAAGTTGGTCTTAAGCTTCCACCTTGAGCAGCCTTG GAAACCTAACCTGCCTCTTTTAGCATAATCACATTTTCTAAATGATTTTCTTTGTTCCTGAAAAAGTGATTTGTATTAGTTTTACATTTG TTTTTTGGAAGATTATATTTGTATATGTATCATCATAAAATATTTAAATAAAAAGTATCTTTAGAGTGACCCTTTCCCCATAGATTTTTA TTTCTCTATTATATTTTACAAGGAATATAACTCAGTTTGTTAGGGAGAGTGCCTTAAAGGCAGGTGTTTCTTGGACTTTGTTATTTAATT >In-frame_ENST00000447393_ENST00000261590_TCGA-N5-A4RD-01A_PACS2_chr14_105818804_+_DSG2_chr18_29104666_length(amino acids)=941AA_start in transcript=175_stop in transcript=3000 MAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVET DLALTFSLQLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANK AAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEI KLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKP PGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLL VPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGR WEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESL NASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEA NAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVV TERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PACS2-DSG2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PACS2-DSG2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PACS2-DSG2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PACS2 | C4748070 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 66 | 2 | GENOMICS_ENGLAND;UNIPROT |
Hgene | PACS2 | C0036572 | Seizures | 1 | GENOMICS_ENGLAND |
Hgene | PACS2 | C0557874 | Global developmental delay | 1 | GENOMICS_ENGLAND |
Hgene | PACS2 | C1866129 | Abnormality of the cerebellum | 1 | GENOMICS_ENGLAND |
Hgene | PACS2 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
Hgene | PACS2 | C4237474 | Unspecified neurodevelopmental disorder | 1 | GENOMICS_ENGLAND |
Tgene | DSG2 | C1857777 | Arrhythmogenic Right Ventricular Dysplasia, Familial, 10 | 6 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | DSG2 | C2752072 | Cardiomyopathy, Dilated, 1BB | 2 | CTD_human;GENOMICS_ENGLAND |
Tgene | DSG2 | C0340427 | Familial dilated cardiomyopathy | 1 | ORPHANET |