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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP35-WDR88 (FusionGDB2 ID:6199)

Fusion Gene Summary for ARHGAP35-WDR88

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP35-WDR88
Fusion gene ID: 6199
HgeneTgene
Gene symbol

ARHGAP35

WDR88

Gene ID

2909

126248

Gene nameRho GTPase activating protein 35WD repeat domain 88
SynonymsGRF-1|GRLF1|P190-A|P190A|p190ARhoGAP|p190RhoGAPPQWD
Cytomap

19q13.32

19q13.11

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 35glucocorticoid receptor DNA-binding factor 1glucocorticoid receptor repression factor 1rho GAP p190AWD repeat-containing protein 88PQQ repeat and WD repeat domain containingPQQ repeat and WD repeat-containing protein
Modification date2020031320200313
UniProtAcc

Q9NRY4

.
Ensembl transtripts involved in fusion geneENST00000404338, ENST00000598548, 
ENST00000592765, ENST00000361680, 
ENST00000355868, 
Fusion gene scores* DoF score19 X 11 X 9=18815 X 7 X 3=105
# samples 196
** MAII scorelog2(19/1881*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/105*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP35 [Title/Abstract] AND WDR88 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP35(47425613)-WDR88(33635750), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP35 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across WDR88 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-ED-A8O6-01AARHGAP35chr19

47425613

+WDR88chr19

33635750

+


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Fusion Gene ORF analysis for ARHGAP35-WDR88

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000404338ENST00000592765ARHGAP35chr19

47425613

+WDR88chr19

33635750

+
In-frameENST00000404338ENST00000361680ARHGAP35chr19

47425613

+WDR88chr19

33635750

+
In-frameENST00000404338ENST00000355868ARHGAP35chr19

47425613

+WDR88chr19

33635750

+
intron-3CDSENST00000598548ENST00000592765ARHGAP35chr19

47425613

+WDR88chr19

33635750

+
intron-3CDSENST00000598548ENST00000361680ARHGAP35chr19

47425613

+WDR88chr19

33635750

+
intron-3CDSENST00000598548ENST00000355868ARHGAP35chr19

47425613

+WDR88chr19

33635750

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000404338ARHGAP35chr1947425613+ENST00000592765WDR88chr1933635750+38653681037881262
ENST00000404338ARHGAP35chr1947425613+ENST00000361680WDR88chr1933635750+50513681045741524
ENST00000404338ARHGAP35chr1947425613+ENST00000355868WDR88chr1933635750+49363681047121570

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000404338ENST00000592765ARHGAP35chr1947425613+WDR88chr1933635750+0.0009211620.99907887
ENST00000404338ENST00000361680ARHGAP35chr1947425613+WDR88chr1933635750+0.0011079020.9988921
ENST00000404338ENST00000355868ARHGAP35chr1947425613+WDR88chr1933635750+0.0006556160.9993444

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Fusion Genomic Features for ARHGAP35-WDR88


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP35chr1947425613+WDR88chr1933635749+6.91E-080.9999999
ARHGAP35chr1947425613+WDR88chr1933635749+6.91E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP35-WDR88


check button Go to

FGviewer for the breakpoints of chr19:47425613-chr19:33635750

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP35

Q9NRY4

.
FUNCTION: Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+16270_3271227.01500.0DomainNote=FF 1
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+16368_4221227.01500.0DomainNote=FF 2
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+16429_4831227.01500.0DomainNote=FF 3
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+16485_5501227.01500.0DomainNote=FF 4
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+16592_7671227.01500.0DomainpG1 pseudoGTPase
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+16783_9471227.01500.0DomainpG2 pseudoGTPase
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+16201_2031227.01500.0Nucleotide bindingGTP
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+16229_2311227.01500.0Nucleotide bindingGTP
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+1633_371227.01500.0Nucleotide bindingGTP
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+1695_971227.01500.0Nucleotide bindingGTP
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+161_2661227.01500.0RegionHas GTPase activity%2C required for proper localization
TgeneWDR88chr19:47425613chr19:33635750ENST00000355868111452_458129.0473.0Compositional biasNote=Poly-Ser
TgeneWDR88chr19:47425613chr19:33635750ENST00000361680112452_458129.0442.3333333333333Compositional biasNote=Poly-Ser
TgeneWDR88chr19:47425613chr19:33635750ENST00000355868111143_182129.0473.0RepeatNote=WD 2
TgeneWDR88chr19:47425613chr19:33635750ENST00000355868111184_224129.0473.0RepeatNote=WD 3
TgeneWDR88chr19:47425613chr19:33635750ENST00000355868111228_267129.0473.0RepeatNote=WD 4
TgeneWDR88chr19:47425613chr19:33635750ENST00000355868111271_310129.0473.0RepeatNote=WD 5
TgeneWDR88chr19:47425613chr19:33635750ENST00000355868111319_358129.0473.0RepeatNote=WD 6
TgeneWDR88chr19:47425613chr19:33635750ENST00000355868111361_400129.0473.0RepeatNote=WD 7
TgeneWDR88chr19:47425613chr19:33635750ENST00000361680112143_182129.0442.3333333333333RepeatNote=WD 2
TgeneWDR88chr19:47425613chr19:33635750ENST00000361680112184_224129.0442.3333333333333RepeatNote=WD 3
TgeneWDR88chr19:47425613chr19:33635750ENST00000361680112228_267129.0442.3333333333333RepeatNote=WD 4
TgeneWDR88chr19:47425613chr19:33635750ENST00000361680112271_310129.0442.3333333333333RepeatNote=WD 5
TgeneWDR88chr19:47425613chr19:33635750ENST00000361680112319_358129.0442.3333333333333RepeatNote=WD 6
TgeneWDR88chr19:47425613chr19:33635750ENST00000361680112361_400129.0442.3333333333333RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+161440_14901227.01500.0Compositional biasNote=Pro-rich
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+161249_14361227.01500.0DomainRho-GAP
HgeneARHGAP35chr19:47425613chr19:33635750ENST00000404338+161213_12361227.01500.0RegionRequired for phospholipid binding and regulation of the substrate preference
TgeneWDR88chr19:47425613chr19:33635750ENST00000355868111100_139129.0473.0RepeatNote=WD 1
TgeneWDR88chr19:47425613chr19:33635750ENST00000361680112100_139129.0442.3333333333333RepeatNote=WD 1


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Fusion Gene Sequence for ARHGAP35-WDR88


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000404338_ENST00000592765_TCGA-ED-A8O6-01A_ARHGAP35_chr19_47425613_+_WDR88_chr19_33635750_length(transcript)=3865nt_BP=3681nt
ATGATGATGGCAAGAAAGCAAGATGTCCGAATTCCCACCTACAACATCAGTGTGGTGGGATTATCTGGGACCGAGAAGGAAAAGGGCCAG
TGTGGGATTGGAAAGTCTTGTTTGTGCAACCGCTTCGTGCGCCCGAGTGCTGACGAGTTTCACTTGGACCATACCTCCGTCCTCAGCACC
AGTGACTTTGGAGGGCGAGTGGTCAATAATGACCACTTTCTCTACTGGGGAGAAGTTAGCCGCTCCCTGGAGGATTGTGTGGAATGTAAG
ATGCACATTGTGGAGCAGACTGAATTTATTGATGATCAGACTTTTCAACCTCATCGAAGCACGGCCCTGCAGCCCTATATCAAGAGAGCT
GCTGCGACCAAGCTTGCATCAGCTGAAAAACTCATGTACTTTTGCACTGACCAGCTGGGGCTGGAGCAGGACTTTGAGCAGAAACAAATG
CCAGACGGAAAGCTGCTGGTTGATGGTTTTCTTCTTGGTATTGATGTTAGCAGGGGCATGAATAGGAACTTTGATGACCAGCTCAAGTTT
GTCTCCAATCTCTACAATCAGCTTGCAAAAACAAAAAAGCCCATAGTGGTGGTCCTGACTAAGTGTGACGAAGGTGTTGAGCGGTACATT
AGAGATGCACATACTTTTGCCTTAAGCAAAAAGAACCTCCAGGTTGTGGAGACCTCAGCGAGATCCAATGTAAACGTGGACTTGGCTTTC
AGCACCTTAGTGCAACTCATTGATAAAAGTCGGGGAAAGACAAAAATCATTCCTTATTTTGAAGCTCTCAAGCAGCAGAGTCAGCAGATA
GCTACAGCAAAAGACAAGTATGAGTGGCTGGTGAGTCGCATTGTGAAAAACCACAATGAGAACTGGCTGAGTGTCAGCCGAAAGATGCAG
GCCTCTCCAGAATACCAGGACTATGTCTACCTGGAAGGGACTCAGAAAGCCAAGAAGCTGTTTCTACAGCACATCCACCGCCTCAAGCAT
GAGCATATCGAGCGTAGGAGAAAGCTGTACCTGGCAGCCCTGCCATTAGCTTTTGAAGCTCTTATACCTAATCTAGATGAAATAGACCAC
CTAAGCTGCATAAAAGCCAAAAAGCTCTTAGAAACCAAGCCAGAATTCTTGAAGTGGTTTGTTGTGCTTGAAGAGACCCCATGGGATGCC
ACCAGTCACATTGACAACATGGAAAACGAACGGATTCCCTTTGATTTAATGGATACCGTCCCTGCAGAGCAGCTATACGAGGCCCACTTA
GAGAAGCTGAGGAACGAAAGGAAAAGAGTTGAGATGCGAAGGGCGTTTAAAGAAAACCTGGAGACTTCTCCTTTCATAACTCCCGGAAAG
CCTTGGGAAGAGGCCCGTAGTTTTATTATGAATGAGGATTTCTACCAGTGGCTGGAGGAATCTGTATACATGGATATTTATGGCAAACAC
CAAAAGCAAATTATAGATAAAGCAAAGGAAGAATTTCAGGAGTTGCTTTTGGAATATTCAGAATTGTTTTATGAACTGGAGCTGGATGCT
AAGCCCAGCAAGGAGAAGATGGGTGTTATTCAGGATGTTCTGGGAGAGGAACAGCGATTTAAAGCATTACAAAAGCTCCAAGCAGAGCGT
GATGCCCTTATTCTGAAACACATTCATTTTGTGTACCACCCAACAAAGGAGACATGCCCCAGCTGCCCAGCTTGTGTGGACGCTAAGATT
GAGCACTTGATTAGTTCTCGGTTTATCCGGCCGTCTGACCGGAATCAGAAAAATTCACTCTCTGACCCTAACATTGATAGAATCAACTTG
GTTATATTGGGCAAAGACGGCCTTGCCCGAGAGTTGGCCAATGAGATTCGAGCTCTTTGTACAAATGATGACAAGTATGTGATAGATGGT
AAAATGTATGAGCTTTCCCTGAGGCCAATAGAGGGGAATGTCAGGCTTCCTGTGAACTCTTTCCAGACGCCAACATTTCAGCCCCACGGC
TGTCTCTGCCTTTACAATTCAAAGGAATCGCTATCCTATGTAGTGGAAAGTATAGAGAAGAGTAGAGAGTCCACGCTGGGCCGGCGGGAT
AATCATTTAGTCCATCTCCCCCTTACATTAATTTTGGTTAACAAGAGAGGAGACACCAGTGGAGAGACTCTGCATAGCTTAATACAGCAA
GGTCAACAAATTGCTAGCAAACTTCAGTGTGTCTTTCTCGACCCTGCTTCTGCTGGCATTGGTTACGGACGCAACATTAATGAAAAGCAA
ATCAGTCAAGTTTTGAAGGGACTCCTGGACTCTAAGCGTAACTTAAACCTGGTCAGTTCTACTGCTAGCATCAAAGATTTGGCTGATGTT
GATCTGCGAATTGTTATGTGTCTGATGTGTGGAGATCCTTTTAGTGCAGATGACATACTTTTTCCTGTCCTTCAGTCCCAAACCTGTAAA
TCTTCCCATTGTGGAAGCAACAACTCTGTTTTACTTGAACTACCAATCGGACTGCACAAGAAGCGGATTGAACTGTCTGTTCTTTCATAC
CATTCCTCCTTTAGCATCAGAAAGAGCCGGTTGGTTCATGGGTACATTGTTTTTTATTCAGCCAAACGTAAGGCCTCTTTGGCTATGTTA
CGTGCCTTTCTTTGTGAAGTGCAGGATATTATCCCTATTCAGCTTGTAGCACTCACTGATGGCGCTGTAGATGTCCTGGACAATGACTTA
AGTAGGGAACAGCTAACTGAGGGGGAGGAGATTGCTCAAGAAATTGACGGAAGGTTCACAAGCATCCCCTGTAGCCAACCCCAGCATAAA
CTTGAGATCTTTCACCCATTTTTTAAAGATGTGGTGGAAAAAAAGAACATAATCGAGGCTACTCATATGTACGATAATGCTGCCGAGGCC
TGTAGCACCACCGAAGAGGTGTTTAACTCCCCCCGGGCAGGATCACCGCTCTGCAACTCAAACCTGCAGGATTCAGAAGAAGATATCGAG
CCATCTTACAGCCTGTTTCGAGAAGACACATCACTGCCTTCTCTGTCCAAAGACCATTCTAAGCTCTCTATGGAACTGGAGGGAAATGAT
GGGCTGTCTTTCATTATGAGCAATTTTGAGAGTAAACTGAACAACAAAGTACCTCCGCCAGTCAAACCAAAGCCTCCTGTCCATTTTGAA
ATTACAAAGGGGGATCTATCTTATTTAGACCAAGGCCATAGGGATGGACAGAGGAAGTCTGTGTCTTCTAGCCCCTGGCTGCCTCAGGAT
GGGTTTGATCCTTCTGACTATGCTGAACCCATGGATGCTGTGGTGAAGCCAAGGAATGAAGAAGAAAACATATACTCCGTGCCCCATGAC
AGCACCCAAGGCAAAATCATCACCATTCGGAATATCAACAAAGCCCAGTCCAACGGCAGCGGGAATGGTTCTGACAGTGAAATGGACACC
AGCTCTCTAGAGCGAGGGCGCAAGGTTTCCATCGTGAGCAAGCCAGTGCTGTACAGGACGAGATGCACCCGGCTGGGGCGGTTTGCTAGT
TACCGGACCAGCTTCAGCGTGGGGAGTGATGATGAGCTGGGGCCCATCCGGAAGAAAGAGGAGGATCAGGCATCCCAGGGTTATAAAGGG
GACAATGCTGTCATTCCATACGAAACAGACGAAGACCCGCGGAGGAGGAATATTCTTCGCAGCCTAAGGAGGAACACTAAGGATCCGGTG
GACGGTTCTGTGGTTCGCGATTTTGAGCACAGGCCCAAAGCTCCTGTTGTAGAGTGCAGCATCACCGGCGACAGCAGCAGTCATTGCCGC

>In-frame_ENST00000404338_ENST00000592765_TCGA-ED-A8O6-01A_ARHGAP35_chr19_47425613_+_WDR88_chr19_33635750_length(amino acids)=1262AA_start in transcript=0_stop in transcript=3788
MMMARKQDVRIPTYNISVVGLSGTEKEKGQCGIGKSCLCNRFVRPSADEFHLDHTSVLSTSDFGGRVVNNDHFLYWGEVSRSLEDCVECK
MHIVEQTEFIDDQTFQPHRSTALQPYIKRAAATKLASAEKLMYFCTDQLGLEQDFEQKQMPDGKLLVDGFLLGIDVSRGMNRNFDDQLKF
VSNLYNQLAKTKKPIVVVLTKCDEGVERYIRDAHTFALSKKNLQVVETSARSNVNVDLAFSTLVQLIDKSRGKTKIIPYFEALKQQSQQI
ATAKDKYEWLVSRIVKNHNENWLSVSRKMQASPEYQDYVYLEGTQKAKKLFLQHIHRLKHEHIERRRKLYLAALPLAFEALIPNLDEIDH
LSCIKAKKLLETKPEFLKWFVVLEETPWDATSHIDNMENERIPFDLMDTVPAEQLYEAHLEKLRNERKRVEMRRAFKENLETSPFITPGK
PWEEARSFIMNEDFYQWLEESVYMDIYGKHQKQIIDKAKEEFQELLLEYSELFYELELDAKPSKEKMGVIQDVLGEEQRFKALQKLQAER
DALILKHIHFVYHPTKETCPSCPACVDAKIEHLISSRFIRPSDRNQKNSLSDPNIDRINLVILGKDGLARELANEIRALCTNDDKYVIDG
KMYELSLRPIEGNVRLPVNSFQTPTFQPHGCLCLYNSKESLSYVVESIEKSRESTLGRRDNHLVHLPLTLILVNKRGDTSGETLHSLIQQ
GQQIASKLQCVFLDPASAGIGYGRNINEKQISQVLKGLLDSKRNLNLVSSTASIKDLADVDLRIVMCLMCGDPFSADDILFPVLQSQTCK
SSHCGSNNSVLLELPIGLHKKRIELSVLSYHSSFSIRKSRLVHGYIVFYSAKRKASLAMLRAFLCEVQDIIPIQLVALTDGAVDVLDNDL
SREQLTEGEEIAQEIDGRFTSIPCSQPQHKLEIFHPFFKDVVEKKNIIEATHMYDNAAEACSTTEEVFNSPRAGSPLCNSNLQDSEEDIE
PSYSLFREDTSLPSLSKDHSKLSMELEGNDGLSFIMSNFESKLNNKVPPPVKPKPPVHFEITKGDLSYLDQGHRDGQRKSVSSSPWLPQD
GFDPSDYAEPMDAVVKPRNEEENIYSVPHDSTQGKIITIRNINKAQSNGSGNGSDSEMDTSSLERGRKVSIVSKPVLYRTRCTRLGRFAS
YRTSFSVGSDDELGPIRKKEEDQASQGYKGDNAVIPYETDEDPRRRNILRSLRRNTKDPVDGSVVRDFEHRPKAPVVECSITGDSSSHCR

--------------------------------------------------------------
>In-frame_ENST00000404338_ENST00000361680_TCGA-ED-A8O6-01A_ARHGAP35_chr19_47425613_+_WDR88_chr19_33635750_length(transcript)=5051nt_BP=3681nt
ATGATGATGGCAAGAAAGCAAGATGTCCGAATTCCCACCTACAACATCAGTGTGGTGGGATTATCTGGGACCGAGAAGGAAAAGGGCCAG
TGTGGGATTGGAAAGTCTTGTTTGTGCAACCGCTTCGTGCGCCCGAGTGCTGACGAGTTTCACTTGGACCATACCTCCGTCCTCAGCACC
AGTGACTTTGGAGGGCGAGTGGTCAATAATGACCACTTTCTCTACTGGGGAGAAGTTAGCCGCTCCCTGGAGGATTGTGTGGAATGTAAG
ATGCACATTGTGGAGCAGACTGAATTTATTGATGATCAGACTTTTCAACCTCATCGAAGCACGGCCCTGCAGCCCTATATCAAGAGAGCT
GCTGCGACCAAGCTTGCATCAGCTGAAAAACTCATGTACTTTTGCACTGACCAGCTGGGGCTGGAGCAGGACTTTGAGCAGAAACAAATG
CCAGACGGAAAGCTGCTGGTTGATGGTTTTCTTCTTGGTATTGATGTTAGCAGGGGCATGAATAGGAACTTTGATGACCAGCTCAAGTTT
GTCTCCAATCTCTACAATCAGCTTGCAAAAACAAAAAAGCCCATAGTGGTGGTCCTGACTAAGTGTGACGAAGGTGTTGAGCGGTACATT
AGAGATGCACATACTTTTGCCTTAAGCAAAAAGAACCTCCAGGTTGTGGAGACCTCAGCGAGATCCAATGTAAACGTGGACTTGGCTTTC
AGCACCTTAGTGCAACTCATTGATAAAAGTCGGGGAAAGACAAAAATCATTCCTTATTTTGAAGCTCTCAAGCAGCAGAGTCAGCAGATA
GCTACAGCAAAAGACAAGTATGAGTGGCTGGTGAGTCGCATTGTGAAAAACCACAATGAGAACTGGCTGAGTGTCAGCCGAAAGATGCAG
GCCTCTCCAGAATACCAGGACTATGTCTACCTGGAAGGGACTCAGAAAGCCAAGAAGCTGTTTCTACAGCACATCCACCGCCTCAAGCAT
GAGCATATCGAGCGTAGGAGAAAGCTGTACCTGGCAGCCCTGCCATTAGCTTTTGAAGCTCTTATACCTAATCTAGATGAAATAGACCAC
CTAAGCTGCATAAAAGCCAAAAAGCTCTTAGAAACCAAGCCAGAATTCTTGAAGTGGTTTGTTGTGCTTGAAGAGACCCCATGGGATGCC
ACCAGTCACATTGACAACATGGAAAACGAACGGATTCCCTTTGATTTAATGGATACCGTCCCTGCAGAGCAGCTATACGAGGCCCACTTA
GAGAAGCTGAGGAACGAAAGGAAAAGAGTTGAGATGCGAAGGGCGTTTAAAGAAAACCTGGAGACTTCTCCTTTCATAACTCCCGGAAAG
CCTTGGGAAGAGGCCCGTAGTTTTATTATGAATGAGGATTTCTACCAGTGGCTGGAGGAATCTGTATACATGGATATTTATGGCAAACAC
CAAAAGCAAATTATAGATAAAGCAAAGGAAGAATTTCAGGAGTTGCTTTTGGAATATTCAGAATTGTTTTATGAACTGGAGCTGGATGCT
AAGCCCAGCAAGGAGAAGATGGGTGTTATTCAGGATGTTCTGGGAGAGGAACAGCGATTTAAAGCATTACAAAAGCTCCAAGCAGAGCGT
GATGCCCTTATTCTGAAACACATTCATTTTGTGTACCACCCAACAAAGGAGACATGCCCCAGCTGCCCAGCTTGTGTGGACGCTAAGATT
GAGCACTTGATTAGTTCTCGGTTTATCCGGCCGTCTGACCGGAATCAGAAAAATTCACTCTCTGACCCTAACATTGATAGAATCAACTTG
GTTATATTGGGCAAAGACGGCCTTGCCCGAGAGTTGGCCAATGAGATTCGAGCTCTTTGTACAAATGATGACAAGTATGTGATAGATGGT
AAAATGTATGAGCTTTCCCTGAGGCCAATAGAGGGGAATGTCAGGCTTCCTGTGAACTCTTTCCAGACGCCAACATTTCAGCCCCACGGC
TGTCTCTGCCTTTACAATTCAAAGGAATCGCTATCCTATGTAGTGGAAAGTATAGAGAAGAGTAGAGAGTCCACGCTGGGCCGGCGGGAT
AATCATTTAGTCCATCTCCCCCTTACATTAATTTTGGTTAACAAGAGAGGAGACACCAGTGGAGAGACTCTGCATAGCTTAATACAGCAA
GGTCAACAAATTGCTAGCAAACTTCAGTGTGTCTTTCTCGACCCTGCTTCTGCTGGCATTGGTTACGGACGCAACATTAATGAAAAGCAA
ATCAGTCAAGTTTTGAAGGGACTCCTGGACTCTAAGCGTAACTTAAACCTGGTCAGTTCTACTGCTAGCATCAAAGATTTGGCTGATGTT
GATCTGCGAATTGTTATGTGTCTGATGTGTGGAGATCCTTTTAGTGCAGATGACATACTTTTTCCTGTCCTTCAGTCCCAAACCTGTAAA
TCTTCCCATTGTGGAAGCAACAACTCTGTTTTACTTGAACTACCAATCGGACTGCACAAGAAGCGGATTGAACTGTCTGTTCTTTCATAC
CATTCCTCCTTTAGCATCAGAAAGAGCCGGTTGGTTCATGGGTACATTGTTTTTTATTCAGCCAAACGTAAGGCCTCTTTGGCTATGTTA
CGTGCCTTTCTTTGTGAAGTGCAGGATATTATCCCTATTCAGCTTGTAGCACTCACTGATGGCGCTGTAGATGTCCTGGACAATGACTTA
AGTAGGGAACAGCTAACTGAGGGGGAGGAGATTGCTCAAGAAATTGACGGAAGGTTCACAAGCATCCCCTGTAGCCAACCCCAGCATAAA
CTTGAGATCTTTCACCCATTTTTTAAAGATGTGGTGGAAAAAAAGAACATAATCGAGGCTACTCATATGTACGATAATGCTGCCGAGGCC
TGTAGCACCACCGAAGAGGTGTTTAACTCCCCCCGGGCAGGATCACCGCTCTGCAACTCAAACCTGCAGGATTCAGAAGAAGATATCGAG
CCATCTTACAGCCTGTTTCGAGAAGACACATCACTGCCTTCTCTGTCCAAAGACCATTCTAAGCTCTCTATGGAACTGGAGGGAAATGAT
GGGCTGTCTTTCATTATGAGCAATTTTGAGAGTAAACTGAACAACAAAGTACCTCCGCCAGTCAAACCAAAGCCTCCTGTCCATTTTGAA
ATTACAAAGGGGGATCTATCTTATTTAGACCAAGGCCATAGGGATGGACAGAGGAAGTCTGTGTCTTCTAGCCCCTGGCTGCCTCAGGAT
GGGTTTGATCCTTCTGACTATGCTGAACCCATGGATGCTGTGGTGAAGCCAAGGAATGAAGAAGAAAACATATACTCCGTGCCCCATGAC
AGCACCCAAGGCAAAATCATCACCATTCGGAATATCAACAAAGCCCAGTCCAACGGCAGCGGGAATGGTTCTGACAGTGAAATGGACACC
AGCTCTCTAGAGCGAGGGCGCAAGGTTTCCATCGTGAGCAAGCCAGTGCTGTACAGGACGAGATGCACCCGGCTGGGGCGGTTTGCTAGT
TACCGGACCAGCTTCAGCGTGGGGAGTGATGATGAGCTGGGGCCCATCCGGAAGAAAGAGGAGGATCAGGCATCCCAGGGTTATAAAGGG
GACAATGCTGTCATTCCATACGAAACAGACGAAGACCCGCGGAGGAGGAATATTCTTCGCAGCCTAAGGAGGAACACTAAGGATCCGGTG
GACGGTTCTGTGGTTCGCGATTTTGAGCACAGGCCCAAAGCTCCTGTTGTAGAGTGCAGCATCACCGGCGACAGCAGCAGAGTCATTGCC
GCATCCTATGATAAGACAGTGAGGGCCTGGGACCTGGAGACAGGCAAGCTGCTGTGGAAGGTCAGGTATGATACCTTCATCGTCTCCTGT
AAGTTTTCTCCTGATGGTAAATACGTGGTCTCAGGCTTCGACGTGGATCATGGAATCTGCATAATGGACGCCGAGAACATCACCACCGTT
TCCGTCATCAAAGATCATCACACAAGGTCCATCACGTCATGCTGCTTTGACCCCGACAGCCAGAGGGTGGCTTCTGTCTCATTGGACAGG
TGCATCAAGATCTGGGATGTTACATCCCAGGCCACGCTGCTCACCATCACTAAGGCACATTCCAATGCAATCTCAAACTGCTGTTTTACC
TTCAGTGGCCATTTCCTGTGTACAAGCTCCTGGGATAAAAACTTAAAAATATGGAACGTCCACACAGGGGAGTTTCGAAACTGTGGAGCC
TGTGTGACTCTGATGCAGGGCCATGAAGGTTCTGTCAGTTCCTGTCACTTTGCCAGAGACAGCTCTTTTCTCATTTCTGGAGGGTTTGAT
AGGACTGTGGCTATTTGGGATGTAGCAGAAGGCTACCGGAAGCTCTCTTTGAAGGGCCATAATGACTGGGTGATGGATGTTGCCATTAGC
AACAACAAGAAATGGATCCTGTCTGCTTCCAAGGATAGGACCATGAGACTGTGGAATATTGAAGAAATTGATGAAATTCCTTTGGTAATC
AAGTACAAAAAGGCCGTGGGCTTAAAGTTGAAACAGGAAAAGAAAGAGGCCTACCTGAAGCTGAAGCAAGGATGAGCCTGCTGCATTTGA
CTTGCTCTGAATCAATCAACATGAGAAGCCTGAGGCCAGGCTTCCCCGAGGCCTGCCCCAGTGCGAAAGATGTGACAGGCCTTTCTCCAT
CTTCAAGAGTGACACCTCTTCTGAAATGTTCACCCAATGCGTGTTCTGCCGGATAGATACAAGGGGCTTGCCAGCAGATACTTCATCGTC
ATCATCATCATCGGAAAGGGAGAACTCACCGCCGCCAAGGGGAAGCAAGGATGACTGACAGCCACAGGCCCCTTTGAGTGACTCCAGCAC
AGGCTACCTAGCATGTAGGTTTCGGGGCTTTGCAGGGGCTTTCTCTTGGGCCCCTCCCAGGCTCAGCAGGCCTGTCAGACTGGGGCAGGA
CCCAAGCCCTGGCTGGACTCAGCACAGTGCCACCTCCTCAGCTCTCAGCTTGGGGAGTGAACACTTTCCGTTTTCATGCAGAATAAATCT

>In-frame_ENST00000404338_ENST00000361680_TCGA-ED-A8O6-01A_ARHGAP35_chr19_47425613_+_WDR88_chr19_33635750_length(amino acids)=1524AA_start in transcript=0_stop in transcript=4574
MMMARKQDVRIPTYNISVVGLSGTEKEKGQCGIGKSCLCNRFVRPSADEFHLDHTSVLSTSDFGGRVVNNDHFLYWGEVSRSLEDCVECK
MHIVEQTEFIDDQTFQPHRSTALQPYIKRAAATKLASAEKLMYFCTDQLGLEQDFEQKQMPDGKLLVDGFLLGIDVSRGMNRNFDDQLKF
VSNLYNQLAKTKKPIVVVLTKCDEGVERYIRDAHTFALSKKNLQVVETSARSNVNVDLAFSTLVQLIDKSRGKTKIIPYFEALKQQSQQI
ATAKDKYEWLVSRIVKNHNENWLSVSRKMQASPEYQDYVYLEGTQKAKKLFLQHIHRLKHEHIERRRKLYLAALPLAFEALIPNLDEIDH
LSCIKAKKLLETKPEFLKWFVVLEETPWDATSHIDNMENERIPFDLMDTVPAEQLYEAHLEKLRNERKRVEMRRAFKENLETSPFITPGK
PWEEARSFIMNEDFYQWLEESVYMDIYGKHQKQIIDKAKEEFQELLLEYSELFYELELDAKPSKEKMGVIQDVLGEEQRFKALQKLQAER
DALILKHIHFVYHPTKETCPSCPACVDAKIEHLISSRFIRPSDRNQKNSLSDPNIDRINLVILGKDGLARELANEIRALCTNDDKYVIDG
KMYELSLRPIEGNVRLPVNSFQTPTFQPHGCLCLYNSKESLSYVVESIEKSRESTLGRRDNHLVHLPLTLILVNKRGDTSGETLHSLIQQ
GQQIASKLQCVFLDPASAGIGYGRNINEKQISQVLKGLLDSKRNLNLVSSTASIKDLADVDLRIVMCLMCGDPFSADDILFPVLQSQTCK
SSHCGSNNSVLLELPIGLHKKRIELSVLSYHSSFSIRKSRLVHGYIVFYSAKRKASLAMLRAFLCEVQDIIPIQLVALTDGAVDVLDNDL
SREQLTEGEEIAQEIDGRFTSIPCSQPQHKLEIFHPFFKDVVEKKNIIEATHMYDNAAEACSTTEEVFNSPRAGSPLCNSNLQDSEEDIE
PSYSLFREDTSLPSLSKDHSKLSMELEGNDGLSFIMSNFESKLNNKVPPPVKPKPPVHFEITKGDLSYLDQGHRDGQRKSVSSSPWLPQD
GFDPSDYAEPMDAVVKPRNEEENIYSVPHDSTQGKIITIRNINKAQSNGSGNGSDSEMDTSSLERGRKVSIVSKPVLYRTRCTRLGRFAS
YRTSFSVGSDDELGPIRKKEEDQASQGYKGDNAVIPYETDEDPRRRNILRSLRRNTKDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIA
ASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDR
CIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFD

--------------------------------------------------------------
>In-frame_ENST00000404338_ENST00000355868_TCGA-ED-A8O6-01A_ARHGAP35_chr19_47425613_+_WDR88_chr19_33635750_length(transcript)=4936nt_BP=3681nt
ATGATGATGGCAAGAAAGCAAGATGTCCGAATTCCCACCTACAACATCAGTGTGGTGGGATTATCTGGGACCGAGAAGGAAAAGGGCCAG
TGTGGGATTGGAAAGTCTTGTTTGTGCAACCGCTTCGTGCGCCCGAGTGCTGACGAGTTTCACTTGGACCATACCTCCGTCCTCAGCACC
AGTGACTTTGGAGGGCGAGTGGTCAATAATGACCACTTTCTCTACTGGGGAGAAGTTAGCCGCTCCCTGGAGGATTGTGTGGAATGTAAG
ATGCACATTGTGGAGCAGACTGAATTTATTGATGATCAGACTTTTCAACCTCATCGAAGCACGGCCCTGCAGCCCTATATCAAGAGAGCT
GCTGCGACCAAGCTTGCATCAGCTGAAAAACTCATGTACTTTTGCACTGACCAGCTGGGGCTGGAGCAGGACTTTGAGCAGAAACAAATG
CCAGACGGAAAGCTGCTGGTTGATGGTTTTCTTCTTGGTATTGATGTTAGCAGGGGCATGAATAGGAACTTTGATGACCAGCTCAAGTTT
GTCTCCAATCTCTACAATCAGCTTGCAAAAACAAAAAAGCCCATAGTGGTGGTCCTGACTAAGTGTGACGAAGGTGTTGAGCGGTACATT
AGAGATGCACATACTTTTGCCTTAAGCAAAAAGAACCTCCAGGTTGTGGAGACCTCAGCGAGATCCAATGTAAACGTGGACTTGGCTTTC
AGCACCTTAGTGCAACTCATTGATAAAAGTCGGGGAAAGACAAAAATCATTCCTTATTTTGAAGCTCTCAAGCAGCAGAGTCAGCAGATA
GCTACAGCAAAAGACAAGTATGAGTGGCTGGTGAGTCGCATTGTGAAAAACCACAATGAGAACTGGCTGAGTGTCAGCCGAAAGATGCAG
GCCTCTCCAGAATACCAGGACTATGTCTACCTGGAAGGGACTCAGAAAGCCAAGAAGCTGTTTCTACAGCACATCCACCGCCTCAAGCAT
GAGCATATCGAGCGTAGGAGAAAGCTGTACCTGGCAGCCCTGCCATTAGCTTTTGAAGCTCTTATACCTAATCTAGATGAAATAGACCAC
CTAAGCTGCATAAAAGCCAAAAAGCTCTTAGAAACCAAGCCAGAATTCTTGAAGTGGTTTGTTGTGCTTGAAGAGACCCCATGGGATGCC
ACCAGTCACATTGACAACATGGAAAACGAACGGATTCCCTTTGATTTAATGGATACCGTCCCTGCAGAGCAGCTATACGAGGCCCACTTA
GAGAAGCTGAGGAACGAAAGGAAAAGAGTTGAGATGCGAAGGGCGTTTAAAGAAAACCTGGAGACTTCTCCTTTCATAACTCCCGGAAAG
CCTTGGGAAGAGGCCCGTAGTTTTATTATGAATGAGGATTTCTACCAGTGGCTGGAGGAATCTGTATACATGGATATTTATGGCAAACAC
CAAAAGCAAATTATAGATAAAGCAAAGGAAGAATTTCAGGAGTTGCTTTTGGAATATTCAGAATTGTTTTATGAACTGGAGCTGGATGCT
AAGCCCAGCAAGGAGAAGATGGGTGTTATTCAGGATGTTCTGGGAGAGGAACAGCGATTTAAAGCATTACAAAAGCTCCAAGCAGAGCGT
GATGCCCTTATTCTGAAACACATTCATTTTGTGTACCACCCAACAAAGGAGACATGCCCCAGCTGCCCAGCTTGTGTGGACGCTAAGATT
GAGCACTTGATTAGTTCTCGGTTTATCCGGCCGTCTGACCGGAATCAGAAAAATTCACTCTCTGACCCTAACATTGATAGAATCAACTTG
GTTATATTGGGCAAAGACGGCCTTGCCCGAGAGTTGGCCAATGAGATTCGAGCTCTTTGTACAAATGATGACAAGTATGTGATAGATGGT
AAAATGTATGAGCTTTCCCTGAGGCCAATAGAGGGGAATGTCAGGCTTCCTGTGAACTCTTTCCAGACGCCAACATTTCAGCCCCACGGC
TGTCTCTGCCTTTACAATTCAAAGGAATCGCTATCCTATGTAGTGGAAAGTATAGAGAAGAGTAGAGAGTCCACGCTGGGCCGGCGGGAT
AATCATTTAGTCCATCTCCCCCTTACATTAATTTTGGTTAACAAGAGAGGAGACACCAGTGGAGAGACTCTGCATAGCTTAATACAGCAA
GGTCAACAAATTGCTAGCAAACTTCAGTGTGTCTTTCTCGACCCTGCTTCTGCTGGCATTGGTTACGGACGCAACATTAATGAAAAGCAA
ATCAGTCAAGTTTTGAAGGGACTCCTGGACTCTAAGCGTAACTTAAACCTGGTCAGTTCTACTGCTAGCATCAAAGATTTGGCTGATGTT
GATCTGCGAATTGTTATGTGTCTGATGTGTGGAGATCCTTTTAGTGCAGATGACATACTTTTTCCTGTCCTTCAGTCCCAAACCTGTAAA
TCTTCCCATTGTGGAAGCAACAACTCTGTTTTACTTGAACTACCAATCGGACTGCACAAGAAGCGGATTGAACTGTCTGTTCTTTCATAC
CATTCCTCCTTTAGCATCAGAAAGAGCCGGTTGGTTCATGGGTACATTGTTTTTTATTCAGCCAAACGTAAGGCCTCTTTGGCTATGTTA
CGTGCCTTTCTTTGTGAAGTGCAGGATATTATCCCTATTCAGCTTGTAGCACTCACTGATGGCGCTGTAGATGTCCTGGACAATGACTTA
AGTAGGGAACAGCTAACTGAGGGGGAGGAGATTGCTCAAGAAATTGACGGAAGGTTCACAAGCATCCCCTGTAGCCAACCCCAGCATAAA
CTTGAGATCTTTCACCCATTTTTTAAAGATGTGGTGGAAAAAAAGAACATAATCGAGGCTACTCATATGTACGATAATGCTGCCGAGGCC
TGTAGCACCACCGAAGAGGTGTTTAACTCCCCCCGGGCAGGATCACCGCTCTGCAACTCAAACCTGCAGGATTCAGAAGAAGATATCGAG
CCATCTTACAGCCTGTTTCGAGAAGACACATCACTGCCTTCTCTGTCCAAAGACCATTCTAAGCTCTCTATGGAACTGGAGGGAAATGAT
GGGCTGTCTTTCATTATGAGCAATTTTGAGAGTAAACTGAACAACAAAGTACCTCCGCCAGTCAAACCAAAGCCTCCTGTCCATTTTGAA
ATTACAAAGGGGGATCTATCTTATTTAGACCAAGGCCATAGGGATGGACAGAGGAAGTCTGTGTCTTCTAGCCCCTGGCTGCCTCAGGAT
GGGTTTGATCCTTCTGACTATGCTGAACCCATGGATGCTGTGGTGAAGCCAAGGAATGAAGAAGAAAACATATACTCCGTGCCCCATGAC
AGCACCCAAGGCAAAATCATCACCATTCGGAATATCAACAAAGCCCAGTCCAACGGCAGCGGGAATGGTTCTGACAGTGAAATGGACACC
AGCTCTCTAGAGCGAGGGCGCAAGGTTTCCATCGTGAGCAAGCCAGTGCTGTACAGGACGAGATGCACCCGGCTGGGGCGGTTTGCTAGT
TACCGGACCAGCTTCAGCGTGGGGAGTGATGATGAGCTGGGGCCCATCCGGAAGAAAGAGGAGGATCAGGCATCCCAGGGTTATAAAGGG
GACAATGCTGTCATTCCATACGAAACAGACGAAGACCCGCGGAGGAGGAATATTCTTCGCAGCCTAAGGAGGAACACTAAGGATCCGGTG
GACGGTTCTGTGGTTCGCGATTTTGAGCACAGGCCCAAAGCTCCTGTTGTAGAGTGCAGCATCACCGGCGACAGCAGCAGAGTCATTGCC
GCATCCTATGATAAGACAGTGAGGGCCTGGGACCTGGAGACAGGCAAGCTGCTGTGGAAGGTCAGGTATGATACCTTCATCGTCTCCTGT
AAGTTTTCTCCTGATGGTAAATACGTGGTCTCAGGCTTCGACGTGGATCATGGAATCTGCATAATGGACGCCGAGAACATCACCACCGTT
TCCGTCATCAAAGATCATCACACAAGGTCCATCACGTCATGCTGCTTTGACCCCGACAGCCAGAGGGTGGCTTCTGTCTCATTGGACAGG
TGCATCAAGATCTGGGATGTTACATCCCAGGCCACGCTGCTCACCATCACTAAGGCACATTCCAATGCAATCTCAAACTGCTGTTTTACC
TTCAGTGGCCATTTCCTGTGTACAAGCTCCTGGGATAAAAACTTAAAAATATGGAACGTCCACACAGGGGAGTTTCGAAACTGTGGAGCC
TGTGTGACTCTGATGCAGGGCCATGAAGGTTCTGTCAGTTCCTGTCACTTTGCCAGAGACAGCTCTTTTCTCATTTCTGGAGGGTTTGAT
AGGACTGTGGCTATTTGGGATGTAGCAGAAGGCTACCGGAAGCTCTCTTTGAAGGGCCATAATGACTGGGTGATGGATGTTGCCATTAGC
AACAACAAGAAATGGATCCTGTCTGCTTCCAAGGATAGGACCATGAGACTGTGGAATATTGAAGAAATTGATGAAATTCCTTTGGTAATC
AAGTACAAAAAGGCCGTGGGCTTAAAGTTGAAACAGTGCGAAAGATGTGACAGGCCTTTCTCCATCTTCAAGAGTGACACCTCTTCTGAA
ATGTTCACCCAATGCGTGTTCTGCCGGATAGATACAAGGGGCTTGCCAGCAGATACTTCATCGTCATCATCATCATCGGAAAGGGAGAAC
TCACCGCCGCCAAGGGGAAGCAAGGATGACTGACAGCCACAGGCCCCTTTGAGTGACTCCAGCACAGGCTACCTAGCATGTAGGTTTCGG
GGCTTTGCAGGGGCTTTCTCTTGGGCCCCTCCCAGGCTCAGCAGGCCTGTCAGACTGGGGCAGGACCCAAGCCCTGGCTGGACTCAGCAC

>In-frame_ENST00000404338_ENST00000355868_TCGA-ED-A8O6-01A_ARHGAP35_chr19_47425613_+_WDR88_chr19_33635750_length(amino acids)=1570AA_start in transcript=0_stop in transcript=4712
MMMARKQDVRIPTYNISVVGLSGTEKEKGQCGIGKSCLCNRFVRPSADEFHLDHTSVLSTSDFGGRVVNNDHFLYWGEVSRSLEDCVECK
MHIVEQTEFIDDQTFQPHRSTALQPYIKRAAATKLASAEKLMYFCTDQLGLEQDFEQKQMPDGKLLVDGFLLGIDVSRGMNRNFDDQLKF
VSNLYNQLAKTKKPIVVVLTKCDEGVERYIRDAHTFALSKKNLQVVETSARSNVNVDLAFSTLVQLIDKSRGKTKIIPYFEALKQQSQQI
ATAKDKYEWLVSRIVKNHNENWLSVSRKMQASPEYQDYVYLEGTQKAKKLFLQHIHRLKHEHIERRRKLYLAALPLAFEALIPNLDEIDH
LSCIKAKKLLETKPEFLKWFVVLEETPWDATSHIDNMENERIPFDLMDTVPAEQLYEAHLEKLRNERKRVEMRRAFKENLETSPFITPGK
PWEEARSFIMNEDFYQWLEESVYMDIYGKHQKQIIDKAKEEFQELLLEYSELFYELELDAKPSKEKMGVIQDVLGEEQRFKALQKLQAER
DALILKHIHFVYHPTKETCPSCPACVDAKIEHLISSRFIRPSDRNQKNSLSDPNIDRINLVILGKDGLARELANEIRALCTNDDKYVIDG
KMYELSLRPIEGNVRLPVNSFQTPTFQPHGCLCLYNSKESLSYVVESIEKSRESTLGRRDNHLVHLPLTLILVNKRGDTSGETLHSLIQQ
GQQIASKLQCVFLDPASAGIGYGRNINEKQISQVLKGLLDSKRNLNLVSSTASIKDLADVDLRIVMCLMCGDPFSADDILFPVLQSQTCK
SSHCGSNNSVLLELPIGLHKKRIELSVLSYHSSFSIRKSRLVHGYIVFYSAKRKASLAMLRAFLCEVQDIIPIQLVALTDGAVDVLDNDL
SREQLTEGEEIAQEIDGRFTSIPCSQPQHKLEIFHPFFKDVVEKKNIIEATHMYDNAAEACSTTEEVFNSPRAGSPLCNSNLQDSEEDIE
PSYSLFREDTSLPSLSKDHSKLSMELEGNDGLSFIMSNFESKLNNKVPPPVKPKPPVHFEITKGDLSYLDQGHRDGQRKSVSSSPWLPQD
GFDPSDYAEPMDAVVKPRNEEENIYSVPHDSTQGKIITIRNINKAQSNGSGNGSDSEMDTSSLERGRKVSIVSKPVLYRTRCTRLGRFAS
YRTSFSVGSDDELGPIRKKEEDQASQGYKGDNAVIPYETDEDPRRRNILRSLRRNTKDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIA
ASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDR
CIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFD
RTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAVGLKLKQCERCDRPFSIFKSDTSSE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP35-WDR88


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP35-WDR88


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP35-WDR88


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP35C0152013Adenocarcinoma of lung (disorder)1CTD_human