FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PAN3-NTRK2 (FusionGDB2 ID:62133)

Fusion Gene Summary for PAN3-NTRK2

check button Fusion gene summary
Fusion gene informationFusion gene name: PAN3-NTRK2
Fusion gene ID: 62133
HgeneTgene
Gene symbol

PAN3

NTRK2

Gene ID

255967

4915

Gene namepoly(A) specific ribonuclease subunit PAN3neurotrophic receptor tyrosine kinase 2
Synonyms-EIEE58|GP145-TrkB|OBHD|TRKB|trk-B
Cytomap

13q12.2

9q21.33

Type of geneprotein-codingprotein-coding
DescriptionPAN2-PAN3 deadenylation complex subunit PAN3PAB-dependent poly(A)-specific ribonuclease subunit 3PAB-dependent poly(A)-specific ribonuclease subunit PAN3PAB1P-dependent poly(A)-nucleasePAB1P-dependent poly(A)-specific ribonucleasePABP-dependent poly(BDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B
Modification date2020032020200313
UniProtAcc.

Q16620

Ensembl transtripts involved in fusion geneENST00000380958, ENST00000399613, 
ENST00000282391, ENST00000483842, 
ENST00000376214, ENST00000376213, 
ENST00000395882, ENST00000304053, 
ENST00000376208, ENST00000277120, 
ENST00000323115, ENST00000359847, 
ENST00000395866, 
Fusion gene scores* DoF score19 X 9 X 12=205210 X 9 X 7=630
# samples 2010
** MAII scorelog2(20/2052*10)=-3.35895882583233
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAN3 [Title/Abstract] AND NTRK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPAN3(28713224)-NTRK2(87549077), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PAN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NTRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BB-4223-01APAN3chr13

28713224

+NTRK2chr9

87549077

+
ChimerDB4HNSCTCGA-BB-4223PAN3chr13

28713224

+NTRK2chr9

87549077

+
ChimerDB4HNSCTCGA-BB-4223-01APAN3chr13

28713224

-NTRK2chr9

87549077

+


Top

Fusion Gene ORF analysis for PAN3-NTRK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000380958ENST00000376214PAN3chr13

28713224

+NTRK2chr9

87549077

+
In-frameENST00000380958ENST00000376213PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000395882PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000304053PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000376208PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000277120PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000323115PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000359847PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000395866PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-3CDSENST00000399613ENST00000376214PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-3CDSENST00000399613ENST00000376213PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000395882PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000304053PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000376208PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000277120PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000323115PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000359847PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000395866PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-3CDSENST00000282391ENST00000376214PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-3CDSENST00000282391ENST00000376213PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000395882PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000304053PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000376208PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000277120PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000323115PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000359847PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000395866PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-3CDSENST00000483842ENST00000376214PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-3CDSENST00000483842ENST00000376213PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000395882PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000304053PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000376208PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000277120PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000323115PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000359847PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000395866PAN3chr13

28713224

+NTRK2chr9

87549077

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380958PAN3chr1328713224+ENST00000376214NTRK2chr987549077+36195821521465437
ENST00000380958PAN3chr1328713224+ENST00000376213NTRK2chr987549077+36195821521465437

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380958ENST00000376214PAN3chr1328713224+NTRK2chr987549077+0.0019316730.9980684
ENST00000380958ENST00000376213PAN3chr1328713224+NTRK2chr987549077+0.0019316730.9980684

Top

Fusion Genomic Features for PAN3-NTRK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PAN3chr1328713224+NTRK2chr987549076+1.87E-070.99999976
PAN3chr1328713224+NTRK2chr987549076+1.87E-070.99999976
PAN3chr1328713224+NTRK2chr987549076+1.87E-070.99999976
PAN3chr1328713224+NTRK2chr987549076+1.87E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PAN3-NTRK2


check button Go to

FGviewer for the breakpoints of chr13:28713224-chr9:87549077

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NTRK2

Q16620

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+11943_71143.33333333333334888.0Zinc fingerC3H1-type
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015148_1960554.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015197_2820554.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015295_3650554.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000030405301532_610554.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015538_8070554.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117538_807528.3333333333334823.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012148_1960478.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012197_2820478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012295_3650478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000035984701232_610478.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012538_8070478.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014148_1960538.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014197_2820538.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014295_3650538.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000037620801432_610538.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014538_8070538.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420538_807528.3333333333334823.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012148_1960322.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012197_2820322.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012295_3650322.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000039586601232_610322.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012538_8070322.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013148_1960478.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013197_2820478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013295_3650478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000039588201332_610478.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013538_8070478.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319544_552544.3333333333334839.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015544_5520554.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117544_552528.3333333333334823.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012544_5520478.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014544_5520538.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420544_552528.3333333333334823.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521544_552544.3333333333334839.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012544_5520322.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013544_5520478.0Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015116_1370554.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000030405301592_1130554.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012116_1370478.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000035984701292_1130478.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014116_1370538.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000037620801492_1130538.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012116_1370322.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000039586601292_1130322.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013116_1370478.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST0000039588201392_1130478.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST0000030405301532_4300554.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015455_8220554.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST0000035984701232_4300478.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012455_8220478.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST0000037620801432_4300538.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014455_8220538.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST0000039586601232_4300322.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012455_8220322.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST0000039588201332_4300478.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013455_8220478.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015431_4540554.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012431_4540478.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014431_4540538.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012431_4540322.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013431_4540478.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114751_7890.0576.0Coiled coilOntology_term=ECO:0000255
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119751_789143.33333333333334888.0Coiled coilOntology_term=ECO:0000255
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118751_7890688.0Coiled coilOntology_term=ECO:0000255
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114284_2990.0576.0MotifPABPC-interacting motif-2 (PAM-2)
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119284_299143.33333333333334888.0MotifPABPC-interacting motif-2 (PAM-2)
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118284_2990688.0MotifPABPC-interacting motif-2 (PAM-2)
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114570_5770.0576.0Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114644_6450.0576.0Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119570_577143.33333333333334888.0Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119644_645143.33333333333334888.0Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118570_5770688.0Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118644_6450688.0Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114463_7500.0576.0RegionPseudokinase domain
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114790_8870.0576.0RegionKnob domain
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119463_750143.33333333333334888.0RegionPseudokinase domain
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119790_887143.33333333333334888.0RegionKnob domain
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118463_7500688.0RegionPseudokinase domain
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118790_8870688.0RegionKnob domain
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+11443_710.0576.0Zinc fingerC3H1-type
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+11843_710688.0Zinc fingerC3H1-type
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319148_196544.3333333333334839.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319197_282544.3333333333334839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319295_365544.3333333333334839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120131932_61544.3333333333334839.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319538_807544.3333333333334839.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117148_196528.3333333333334823.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117197_282528.3333333333334823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117295_365528.3333333333334823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115111732_61528.3333333333334823.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420148_196528.3333333333334823.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420197_282528.3333333333334823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420295_365528.3333333333334823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213142032_61528.3333333333334823.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521148_196544.3333333333334839.0DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521197_282544.3333333333334839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521295_365544.3333333333334839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214152132_61544.3333333333334839.0DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521538_807544.3333333333334839.0DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319116_137544.3333333333334839.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120131992_113544.3333333333334839.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117116_137528.3333333333334823.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115111792_113528.3333333333334823.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420116_137528.3333333333334823.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213142092_113528.3333333333334823.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521116_137544.3333333333334839.0RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214152192_113544.3333333333334839.0RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120131932_430544.3333333333334839.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319455_822544.3333333333334839.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115111732_430528.3333333333334823.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117455_822528.3333333333334823.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213142032_430528.3333333333334823.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420455_822528.3333333333334823.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214152132_430544.3333333333334839.0Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521455_822544.3333333333334839.0Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319431_454544.3333333333334839.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117431_454528.3333333333334823.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420431_454528.3333333333334823.0TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521431_454544.3333333333334839.0TransmembraneHelical


Top

Fusion Gene Sequence for PAN3-NTRK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000380958_ENST00000376214_TCGA-BB-4223-01A_PAN3_chr13_28713224_+_NTRK2_chr9_87549077_length(transcript)=3619nt_BP=582nt
CTCCCCGGGCGGCTCCGGCTCCCGCAGCGGGACAGACCCACCCGCCCAGGCTTTTATCCGGCACCGGCAGCGTCTTCCTTTCCTCCCCCG
TCTATGGTGGTGGCGGCGGCGGCTCCTCGGGCGGCGGCGGAAGACGAGGCTGCGGCGTTGCCATGAACAGTGGCGGCGGCCTCCCGCCCC
CCTCGGCCGCCGCCTCCCCTTCCTCCTCCTCGCTGGCGGCGGCGGTGGCGGTGGTGGCCCCGCCGGGGGTCGGGGGTGTCCCCGGCGGGG
CGGCGGTAGGAGTGAAGCTGAAGTACTGCCGCTACTACGCTAAGGATAAGACTTGCTTCTACGGGGAGGAGTGTCAGTTCCTGCATGAGG
ACCCTGCCGCCGGGGCTGCCCCGGGCCTCGGCCTCCATAGCAACAGCGTCCCCCTGGCTCTGGCTGGTGCACCCGTGGCCGGCTTTCCGC
CGGGAGCCGTCGCGGGCGGGGGAGCTGGGCCGCCCCCCGGGCCCAAGAAGCCGGACCTGGGGGACCCGGGGACCGGAGCCGCAGCCGGCG
GAGGAGGCAGTAGCGGGGGACTCGATGGACCGCGGCTGGCAATTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAG
GCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGA
AGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTATG
GCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTG
ATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGG
TCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACT
TTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCA
TCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGT
ACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGC
TGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTC
CGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGATGAACATC
TTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAG
TGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTC
TTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTA
CTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAACAATGCCT
TGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGATATCGAGA
GTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTT
GTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGGAACAAAGA
CAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGA
GGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTGCAGTAGAGAG
CAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGCACTGGTTTGT
TTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCAGGTGGGAAA
GCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCCCTCCGACC
CCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGCAGACACTACT
GCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAGTTTATTAGCT
GAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCACGTCGAACCCA
CAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAGTGTACACAGG
TCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACTC
CATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATA
GTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGAAAAATATTTC
TGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAAAGGGAGTGAT
TTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGTTAATTACTG
GAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCA
ACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTTGGGTCGTTTG

>In-frame_ENST00000380958_ENST00000376214_TCGA-BB-4223-01A_PAN3_chr13_28713224_+_NTRK2_chr9_87549077_length(amino acids)=437AA_start in transcript=152_stop in transcript=1465
MNSGGGLPPPSAAASPSSSSLAAAVAVVAPPGVGGVPGGAAVGVKLKYCRYYAKDKTCFYGEECQFLHEDPAAGAAPGLGLHSNSVPLAL
AGAPVAGFPPGAVAGGGAGPPPGPKKPDLGDPGTGAAAGGGGSSGGLDGPRLAIVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD
KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH
IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE

--------------------------------------------------------------
>In-frame_ENST00000380958_ENST00000376213_TCGA-BB-4223-01A_PAN3_chr13_28713224_+_NTRK2_chr9_87549077_length(transcript)=3619nt_BP=582nt
CTCCCCGGGCGGCTCCGGCTCCCGCAGCGGGACAGACCCACCCGCCCAGGCTTTTATCCGGCACCGGCAGCGTCTTCCTTTCCTCCCCCG
TCTATGGTGGTGGCGGCGGCGGCTCCTCGGGCGGCGGCGGAAGACGAGGCTGCGGCGTTGCCATGAACAGTGGCGGCGGCCTCCCGCCCC
CCTCGGCCGCCGCCTCCCCTTCCTCCTCCTCGCTGGCGGCGGCGGTGGCGGTGGTGGCCCCGCCGGGGGTCGGGGGTGTCCCCGGCGGGG
CGGCGGTAGGAGTGAAGCTGAAGTACTGCCGCTACTACGCTAAGGATAAGACTTGCTTCTACGGGGAGGAGTGTCAGTTCCTGCATGAGG
ACCCTGCCGCCGGGGCTGCCCCGGGCCTCGGCCTCCATAGCAACAGCGTCCCCCTGGCTCTGGCTGGTGCACCCGTGGCCGGCTTTCCGC
CGGGAGCCGTCGCGGGCGGGGGAGCTGGGCCGCCCCCCGGGCCCAAGAAGCCGGACCTGGGGGACCCGGGGACCGGAGCCGCAGCCGGCG
GAGGAGGCAGTAGCGGGGGACTCGATGGACCGCGGCTGGCAATTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAG
GCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGA
AGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTATG
GCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTG
ATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGG
TCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACT
TTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCA
TCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGT
ACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGC
TGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTC
CGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGATGAACATC
TTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAG
TGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTC
TTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTA
CTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAACAATGCCT
TGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGATATCGAGA
GTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTT
GTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGGAACAAAGA
CAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGA
GGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTGCAGTAGAGAG
CAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGCACTGGTTTGT
TTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCAGGTGGGAAA
GCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCCCTCCGACC
CCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGCAGACACTACT
GCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAGTTTATTAGCT
GAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCACGTCGAACCCA
CAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAGTGTACACAGG
TCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACTC
CATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATA
GTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGAAAAATATTTC
TGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAAAGGGAGTGAT
TTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGTTAATTACTG
GAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCA
ACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTTGGGTCGTTTG

>In-frame_ENST00000380958_ENST00000376213_TCGA-BB-4223-01A_PAN3_chr13_28713224_+_NTRK2_chr9_87549077_length(amino acids)=437AA_start in transcript=152_stop in transcript=1465
MNSGGGLPPPSAAASPSSSSLAAAVAVVAPPGVGGVPGGAAVGVKLKYCRYYAKDKTCFYGEECQFLHEDPAAGAAPGLGLHSNSVPLAL
AGAPVAGFPPGAVAGGGAGPPPGPKKPDLGDPGTGAAAGGGGSSGGLDGPRLAIVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD
KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH
IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PAN3-NTRK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053015455_4660554.0MAPK8IP3/JIP3
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847012455_4660478.0MAPK8IP3/JIP3
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208014455_4660538.0MAPK8IP3/JIP3
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866012455_4660322.0MAPK8IP3/JIP3
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882013455_4660478.0MAPK8IP3/JIP3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneNTRK2chr13:28713224chr9:87549077ENST000002771201319455_466544.3333333333334839.0MAPK8IP3/JIP3
TgeneNTRK2chr13:28713224chr9:87549077ENST000003231151117455_466528.3333333333334823.0MAPK8IP3/JIP3
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762131420455_466528.3333333333334823.0MAPK8IP3/JIP3
TgeneNTRK2chr13:28713224chr9:87549077ENST000003762141521455_466544.3333333333334839.0MAPK8IP3/JIP3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PAN3-NTRK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNTRK2Q16620DB00321AmitriptylineAgonistSmall moleculeApproved
TgeneNTRK2Q16620DB00321AmitriptylineAgonistSmall moleculeApproved
TgeneNTRK2Q16620DB11823EsketamineSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB11823EsketamineSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB11986EntrectinibInhibitorSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB11986EntrectinibInhibitorSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB14723LarotrectinibInhibitorSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB14723LarotrectinibInhibitorSmall moleculeApproved|Investigational

Top

Related Diseases for PAN3-NTRK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNTRK2C0011570Mental Depression5PSYGENET
TgeneNTRK2C0011581Depressive disorder5PSYGENET
TgeneNTRK2C0041696Unipolar Depression5PSYGENET
TgeneNTRK2C0525045Mood Disorders5PSYGENET
TgeneNTRK2C1269683Major Depressive Disorder5PSYGENET
TgeneNTRK2C3151303Obesity, Hyperphagia, and Developmental Delay4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNTRK2C0005586Bipolar Disorder3CTD_human;PSYGENET
TgeneNTRK2C4693367EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 583GENOMICS_ENGLAND;UNIPROT
TgeneNTRK2C0009171Cocaine Abuse2CTD_human
TgeneNTRK2C0036341Schizophrenia2PSYGENET
TgeneNTRK2C0038220Status Epilepticus2CTD_human
TgeneNTRK2C0236736Cocaine-Related Disorders2CTD_human
TgeneNTRK2C0270823Petit mal status2CTD_human
TgeneNTRK2C0311335Grand Mal Status Epilepticus2CTD_human
TgeneNTRK2C0393734Complex Partial Status Epilepticus2CTD_human
TgeneNTRK2C0600427Cocaine Dependence2CTD_human
TgeneNTRK2C0751217Hyperkinesia, Generalized2CTD_human
TgeneNTRK2C0751522Status Epilepticus, Subclinical2CTD_human
TgeneNTRK2C0751523Non-Convulsive Status Epilepticus2CTD_human
TgeneNTRK2C0751524Simple Partial Status Epilepticus2CTD_human
TgeneNTRK2C3887506Hyperkinesia2CTD_human
TgeneNTRK2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNTRK2C0004114Astrocytoma1CTD_human
TgeneNTRK2C0004352Autistic Disorder1CTD_human
TgeneNTRK2C0005587Depression, Bipolar1CTD_human
TgeneNTRK2C0008073Developmental Disabilities1CTD_human
TgeneNTRK2C0013415Dysthymic Disorder1PSYGENET
TgeneNTRK2C0017638Glioma1CTD_human
TgeneNTRK2C0020505Hyperphagia1CTD_human
TgeneNTRK2C0024713Manic Disorder1CTD_human
TgeneNTRK2C0027819Neuroblastoma1CTD_human
TgeneNTRK2C0028754Obesity1CTD_human
TgeneNTRK2C0036349Paranoid Schizophrenia1PSYGENET
TgeneNTRK2C0037769West Syndrome1ORPHANET
TgeneNTRK2C0085996Child Development Deviations1CTD_human
TgeneNTRK2C0085997Child Development Disorders, Specific1CTD_human
TgeneNTRK2C0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneNTRK2C0259783mixed gliomas1CTD_human
TgeneNTRK2C0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneNTRK2C0280785Diffuse Astrocytoma1CTD_human
TgeneNTRK2C0334579Anaplastic astrocytoma1CTD_human
TgeneNTRK2C0334580Protoplasmic astrocytoma1CTD_human
TgeneNTRK2C0334581Gemistocytic astrocytoma1CTD_human
TgeneNTRK2C0334582Fibrillary Astrocytoma1CTD_human
TgeneNTRK2C0334583Pilocytic Astrocytoma1CTD_human
TgeneNTRK2C0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneNTRK2C0338831Manic1CTD_human
TgeneNTRK2C0547065Mixed oligoastrocytoma1CTD_human
TgeneNTRK2C0555198Malignant Glioma1CTD_human
TgeneNTRK2C0678807prenatal alcohol exposure1PSYGENET
TgeneNTRK2C0750935Cerebral Astrocytoma1CTD_human
TgeneNTRK2C0750936Intracranial Astrocytoma1CTD_human
TgeneNTRK2C0752347Lewy Body Disease1CTD_human
TgeneNTRK2C1519086Pilomyxoid astrocytoma1ORPHANET
TgeneNTRK2C1704230Grade I Astrocytoma1CTD_human
TgeneNTRK2C3146244Alcohol Related Birth Defect1PSYGENET