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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP42-PGR (FusionGDB2 ID:6218)

Fusion Gene Summary for ARHGAP42-PGR

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP42-PGR
Fusion gene ID: 6218
HgeneTgene
Gene symbol

ARHGAP42

PGR

Gene ID

143872

5241

Gene nameRho GTPase activating protein 42progesterone receptor
SynonymsAD031|GRAF3|TMEM133NR3C3|PR
Cytomap

11q22.1

11q22.1

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 42rho-type GTPase-activating protein 42transmembrane protein 133progesterone receptornuclear receptor subfamily 3 group C member 3
Modification date2020031320200313
UniProtAcc

A6NI28

.
Ensembl transtripts involved in fusion geneENST00000524892, ENST00000298815, 
ENST00000534060, 		ENST00000325455, 
ENST00000534013, ENST00000263463, 
Fusion gene scores* DoF score11 X 7 X 7=5394 X 3 X 4=48
# samples 124
** MAII scorelog2(12/539*10)=-2.16725086714399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP42 [Title/Abstract] AND PGR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP42(100558563)-PGR(100933483), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP42

GO:0090630

activation of GTPase activity

24335996

TgenePGR

GO:0045944

positive regulation of transcription by RNA polymerase II

17785366


check buttonFusion gene breakpoints across ARHGAP42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PGR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SJ-01AARHGAP42chr11

100558563

+PGRchr11

100933483

-
ChimerDB4BRCATCGA-A1-A0SJARHGAP42chr11

100558563

+PGRchr11

100933483

-
ChimerDB4BRCATCGA-A1-A0SJ-01AARHGAP42chr11

100558563

+PGRchr11

100933483

-
ChimerDB4BRCATCGA-A1-A0SJ-01AARHGAP42chr11

100558563

-PGRchr11

100933483

-


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Fusion Gene ORF analysis for ARHGAP42-PGR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000524892ENST00000325455ARHGAP42chr11

100558563

+PGRchr11

100933483

-
In-frameENST00000524892ENST00000534013ARHGAP42chr11

100558563

+PGRchr11

100933483

-
5CDS-intronENST00000524892ENST00000263463ARHGAP42chr11

100558563

+PGRchr11

100933483

-
In-frameENST00000298815ENST00000325455ARHGAP42chr11

100558563

+PGRchr11

100933483

-
In-frameENST00000298815ENST00000534013ARHGAP42chr11

100558563

+PGRchr11

100933483

-
5CDS-intronENST00000298815ENST00000263463ARHGAP42chr11

100558563

+PGRchr11

100933483

-
intron-3CDSENST00000534060ENST00000325455ARHGAP42chr11

100558563

+PGRchr11

100933483

-
intron-3CDSENST00000534060ENST00000534013ARHGAP42chr11

100558563

+PGRchr11

100933483

-
intron-intronENST00000534060ENST00000263463ARHGAP42chr11

100558563

+PGRchr11

100933483

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000524892ARHGAP42chr11100558563+ENST00000325455PGRchr11100933483-10568180261075349
ENST00000524892ARHGAP42chr11100558563+ENST00000534013PGRchr11100933483-1512180261075349
ENST00000298815ARHGAP42chr11100558563+ENST00000325455PGRchr11100933483-1054515731052349
ENST00000298815ARHGAP42chr11100558563+ENST00000534013PGRchr11100933483-148915731052349

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000524892ENST00000325455ARHGAP42chr11100558563+PGRchr11100933483-0.0011098140.9988902
ENST00000524892ENST00000534013ARHGAP42chr11100558563+PGRchr11100933483-0.001232690.9987674
ENST00000298815ENST00000325455ARHGAP42chr11100558563+PGRchr11100933483-0.0011094030.9988906
ENST00000298815ENST00000534013ARHGAP42chr11100558563+PGRchr11100933483-0.001230660.99876934

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Fusion Genomic Features for ARHGAP42-PGR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP42-PGR


check button Go to

FGviewer for the breakpoints of chr11:100558563-chr11:100933483

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP42

A6NI28

.
FUNCTION: May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePGRchr11:100558563chr11:100933483ENST0000053401328567_63941.333333333333336340.0DNA bindingNuclear receptor
TgenePGRchr11:100558563chr11:100933483ENST0000032545528679_913635.3333333333334934.0DomainNR LBD
TgenePGRchr11:100558563chr11:100933483ENST0000053401328679_91341.333333333333336340.0DomainNR LBD
TgenePGRchr11:100558563chr11:100933483ENST0000053401328115_11941.333333333333336340.0MotifLXXL motif 2
TgenePGRchr11:100558563chr11:100933483ENST0000053401328183_18741.333333333333336340.0MotifNuclear localization signal
TgenePGRchr11:100558563chr11:100933483ENST000005340132855_5941.333333333333336340.0MotifLXXL motif 1
TgenePGRchr11:100558563chr11:100933483ENST0000032545528687_933635.3333333333334934.0RegionAF2%3B mediates transcriptional activation
TgenePGRchr11:100558563chr11:100933483ENST0000053401328165_30541.333333333333336340.0RegionMediates transcriptional transrepression (in isoform A)
TgenePGRchr11:100558563chr11:100933483ENST0000053401328456_54641.333333333333336340.0RegionAF1%3B mediates transcriptional activation
TgenePGRchr11:100558563chr11:100933483ENST0000053401328687_93341.333333333333336340.0RegionAF2%3B mediates transcriptional activation
TgenePGRchr11:100558563chr11:100933483ENST0000053401328567_58741.333333333333336340.0Zinc fingerNR C4-type
TgenePGRchr11:100558563chr11:100933483ENST0000053401328603_62741.333333333333336340.0Zinc fingerNR C4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP42chr11:100558563chr11:100933483ENST00000298815+124225_26151.333333333333336875.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP42chr11:100558563chr11:100933483ENST00000298815+124619_76251.333333333333336875.0Compositional biasNote=Ser-rich
HgeneARHGAP42chr11:100558563chr11:100933483ENST00000298815+124265_37451.333333333333336875.0DomainPH
HgeneARHGAP42chr11:100558563chr11:100933483ENST00000298815+124376_57251.333333333333336875.0DomainRho-GAP
HgeneARHGAP42chr11:100558563chr11:100933483ENST00000298815+1247_26251.333333333333336875.0DomainNote=BAR
HgeneARHGAP42chr11:100558563chr11:100933483ENST00000298815+124816_87451.333333333333336875.0DomainSH3
TgenePGRchr11:100558563chr11:100933483ENST0000032545528567_639635.3333333333334934.0DNA bindingNuclear receptor
TgenePGRchr11:100558563chr11:100933483ENST0000032545528115_119635.3333333333334934.0MotifLXXL motif 2
TgenePGRchr11:100558563chr11:100933483ENST0000032545528183_187635.3333333333334934.0MotifNuclear localization signal
TgenePGRchr11:100558563chr11:100933483ENST000003254552855_59635.3333333333334934.0MotifLXXL motif 1
TgenePGRchr11:100558563chr11:100933483ENST0000032545528165_305635.3333333333334934.0RegionMediates transcriptional transrepression (in isoform A)
TgenePGRchr11:100558563chr11:100933483ENST00000325455281_566635.3333333333334934.0RegionNote=Modulating%2C Pro-Rich
TgenePGRchr11:100558563chr11:100933483ENST0000032545528456_546635.3333333333334934.0RegionAF1%3B mediates transcriptional activation
TgenePGRchr11:100558563chr11:100933483ENST00000534013281_56641.333333333333336340.0RegionNote=Modulating%2C Pro-Rich
TgenePGRchr11:100558563chr11:100933483ENST0000032545528567_587635.3333333333334934.0Zinc fingerNR C4-type
TgenePGRchr11:100558563chr11:100933483ENST0000032545528603_627635.3333333333334934.0Zinc fingerNR C4-type


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Fusion Gene Sequence for ARHGAP42-PGR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000524892_ENST00000325455_TCGA-A1-A0SJ-01A_ARHGAP42_chr11_100558563_+_PGR_chr11_100933483_length(transcript)=10568nt_BP=180nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
GTCGAAAATTTAAAAAGTTCAATAAAGTCAGAGTTGTGAGAGCACTGGATGCTGTTGCTCTCCCACAGCCAGTGGGCGTTCCAAATGAAA
GCCAAGCCCTAAGCCAGAGATTCACTTTTTCACCAGGTCAAGACATACAGTTGATTCCACCACTGATCAACCTGTTAATGAGCATTGAAC
CAGATGTGATCTATGCAGGACATGACAACACAAAACCTGACACCTCCAGTTCTTTGCTGACAAGTCTTAATCAACTAGGCGAGAGGCAAC
TTCTTTCAGTAGTCAAGTGGTCTAAATCATTGCCAGGTTTTCGAAACTTACATATTGATGACCAGATAACTCTCATTCAGTATTCTTGGA
TGAGCTTAATGGTGTTTGGTCTAGGATGGAGATCCTACAAACACGTCAGTGGGCAGATGCTGTATTTTGCACCTGATCTAATACTAAATG
AACAGCGGATGAAAGAATCATCATTCTATTCATTATGCCTTACCATGTGGCAGATCCCACAGGAGTTTGTCAAGCTTCAAGTTAGCCAAG
AAGAGTTCCTCTGTATGAAAGTATTGTTACTTCTTAATACAATTCCTTTGGAAGGGCTACGAAGTCAAACCCAGTTTGAGGAGATGAGGT
CAAGCTACATTAGAGAGCTCATCAAGGCAATTGGTTTGAGGCAAAAAGGAGTTGTGTCGAGCTCACAGCGTTTCTATCAACTTACAAAAC
TTCTTGATAACTTGCATGATCTTGTCAAACAACTTCATCTGTACTGCTTGAATACATTTATCCAGTCCCGGGCACTGAGTGTTGAATTTC
CAGAAATGATGTCTGAAGTTATTGCTGCACAATTACCCAAGATATTGGCAGGGATGGTGAAACCCCTTCTCTTTCATAAAAAGTGAATGT
CATCTTTTTCTTTTAAAGAATTAAATTTTGTGGTATGTCTTTTTGTTTTGGTCAGGATTATGAGGTCTTGAGTTTTTATAATGTTCTTCT
GAAAGCCTTACATTTATAACATCATAGTGTGTAAATTTAAAAGAAAAATTGTGAGGTTCTAATTATTTTCTTTTATAAAGTATAATTAGA
ATGTTTAACTGTTTTGTTTACCCATATTTTCTTGAAGAATTTACAAGATTGAAAAAGTACTAAAATTGTTAAAGTAAACTATCTTATCCA
TATTATTTCATACCATGTAGGTGAGGATTTTTAACTTTTGCATCTAACAAATCATCGACTTAAGAGAAAAAATCTTACATGTAATAACAC
AAAGCTATTATATGTTATTTCTAGGTAACTCCCTTTGTGTCAATTATATTTCCAAAAATGAACCTTTAAAATGGTATGCAAAATTTTGTC
TATATATATTTGTGTGAGGAGGAAATTCATAACTTTCCTCAGATTTTCAAAAGTATTTTTAATGCAAAAAATGTAGAAAGAGTTTAAAAC
CACTAAAATAGATTGATGTTCTTCAAACTAGGCAAAACAACTCATATGTTAAGACCATTTTCCAGATTGGAAACACAAATCTCTTAGGAA
GTTAATAAGTAGATTCATATCATTATGCAAATAGTATTGTGGGTTTTGTAGGTTTTTAAAATAACCTTTTTTGGGGAGAGAATTGTCCTC
TAATGAGGTATTGCGAGTGGACATAAGAAATCAGAAGATTATGGCCTAACTGTACTCCTTACCAACTGTGGCATGCTGAAAGTTAGTCAC
TCTTACTGATTCTCAATTCTCTCACCTTTGAAAGTAGTAAAATATCTTTCCTGCCAATTGCTCCTTTGGGTCAGAGCTTATTAACATCTT
TTCAAATCAAAGGAAAGAAGAAAGGGAGAGGAGGAGGAGGGAGGTATCAATTCACATACCTTTCTCCTCTTTATCCTCCACTATCATGAA
TTCATATTATGTTTCAGCCATGCAAATCTTTTTACCATGAAATTTCTTCCAGAATTTTCCCCCTTTGACACAAATTCCATGCATGTTTCA
ACCTTCGAGACTCAGCCAAATGTCATTTCTGTAAAATCTTCCCTGAGTCTTCCAAGCAGTAATTTGCCTTCTCCTAGAGTTTACCTGCCA
TTTTGTGCACATTTGAGTTACAGTAGCATGTTATTTTACAATTGTGACTCTCCTGGGAGTCTGGGAGCCATATAAAGTGGTCAATAGTGT
TTGCTGACTGAGAGTTGAATGACATTTTCTCTCTGTCTTGGTATTACTGTAGATTTCGATCATTCTTTGGTTACATTTCTGCATATTTCT
GTACCCATGACTTTATCACTTTCTTCTCCCATGCTTTATCTCCATCAATTATCTTCATTACTTTTAAATTTTCCACCTTTGCTTCCTACT
TTGTGAGATCTCTCCCTTTACTGACTATAACATAGAAGAATAGAAGTGTATTTTATGTGTCTTAAGGACAATACTTTAGATTCCTTGTTC
TAAGTTTTTAAACTGAATGAATGGAATATTATTTCTCTCCCTAAGCAAAATTCCACAAAACAATTATTTCTTATGTTTATGTAGCCTTAA
ATTGTTTTGTACTGTAAACCTCAGCATAAAAACTTTCTTCATTTCTAATTTCATTCAACAAATATTGATTGAATACCTGGTATTAGCACA
AGAAAAATGTGCTAATAAGCCTTATGAGAATTTGGAGCTGAAGAAAGACATATAACTCAGGAAAGTTACAGTCCAGTAGTAGGTATAAAT
TACAGTGCCTGATAAATAGGCATTTTAATATTTGTACACTCAACGTATACTAGGTAGGTGCAAAACATTTACATATAATTTTACTGATAC
CCATGCAGCACAAAGGTACTAACTTTAAATATTAAATAACACCTTTATGTGTCAGTAATTCATTTGCATTAAATCTTATTGAAAAGGCTT
TCAATATATTTTCCCCACAAATGTCATCCCAAGAAAAAAGTATTTTTAACATCTCCCAAATATAATAGTTACAGGAAATCTACCTCTGTG
AGAGTGACACCTCTCAGAATGAACTGTGTGACACAAGAAAATGAATGTAGGTCTATCCAAAAAAAACCCCAAGAAACAAAAACAATATTA
TTAGCCCTTTATGCTTAAGTGATGGACTCAGGGAACAGTTGATGTTGTGATCATTTTATTATCTGATTCTTGTTACTTTGAATTAAACCA
ATATTTTGATGATATAAATCATTTCCACCAGCATATATTTAATTTCCATAATAACTTTAAAATTTTCTAATTTCACTCAACTATGAGGGA
ATAGAATGTGGTGGCCACAGGTTTGGCTTTTGTTAAAATGTTTGATATCTTCGATGTTGATCTCTGTCTGCAATGTAGATGTCTAAACAC
TAGGATTTAATATTTAAGGCTAAGCTTTAAAAATAAAGTACCTTTTTAAAAAGAATATGGCTTCACCAAATGGAAAATACCTAATTTCTA
AATCTTTTTCTCTACAAAGTCCTATCTACTAATGTCTCCATTACTATTTAGTCATCATAACCATTATCTTCATTTTACATGTCGTGTTCT
TTCTGGTAGCTCTAAAATGACACTAAATCATAAGAAGACAGGTTACATATCAGGAAATACTTGAAGGTTACTGAAATAGATTCTTGAGTT
AATGAAAATATTTTCTGTAAAAAGGTTTGAAAAGCCATTTGAGTCTAAAGCATTATACCTCCATTATCAGTAGTTATGTGACAATTGTGT
GTGTGTTTAATGTTTAAAGATGTGGCACTTTTTAATAAGGCAATGCTATGCTATTTTTTCCCATTTAACATTAAGATAATTTATTGCTAT
ACAGATGATATGGAAATATGATGAACAATATTTTTTTTGCCAAAACTATGCCTTGTAAGTAGCCATGGAATGTCAACCTGTAACTTAAAT
TATCCACAGATAGTCATGTGTTTGATGATGGGCACTGTGGAGATAACTGACATAGGACTGTGCCCCCCTTCTCTGCCACTTACTAGCTGG
ATGAGATTAAGCAAGTCATTTAACTGCTCTGATTAAACCTGCCTTTCCCAAGTGCTTTGTAATGAATAGAAATGGAAACCAAAAAAAACG
TATACAGGCCTTCAGAAATAGTAATTGCTACTATTTTGTTTTCATTAAGCCATAGTTCTGGCTATAATTTTATCAAACTCACCAGCTATA
TTCTACAGTGAAAGCAGGATTCTAGAAAGTCTCACTGTTTTATTTATGTCACCATGTGCTATGATATATTTGGTTGAATTCATTTGAAAT
TAGGGCTGGAAGTATTCAAGTAATTTCTTCTGCTGAAAAAATACAGTGTTTTGAGTTTAGGGCCTGTTTTATCAAAGTTCTAAAGAGCCT
ATCACTCTTCCATTGTAGACATTTTAAAATAATGACACTGATTTTAACATTTTTAAGTGTCTTTTTAGAACAGAGAGCCTGACTAGAACA
CAGCCCCTCCAAAAACCCATGCTCAAATTATTTTTACTATGGCAGCAATTCCACAAAAGGGAACAATGGGTTTAGAAATTACAATGAAGT
CATCAACCCAAAAAACATCCCTATCCCTAAGAAGGTTATGATATAAAATGCCCACAAGAAATCTATGTCTGCTTTAATCTGTCTTTTATT
GCTTTGGAAGGATGGCTATTACATTTTTAGTTTTTGCTGTGAATACCTGAGCAGTTTCTCTCATCCATACTTATCCTTCACACATCAGAA
GTCAGGATAGAATATGAATCATTTTAAAAACTTTTACAACTCCAGAGCCATGTGCATAAGAAGCATTCAAAACTTGCCAAAACATACATT
TTTTTTCAAATTTAAAGATACTCTATTTTTGTATTCAATAGCTCAACAACTGTGGTCCCCACTGATAAAGTGAAGTGGACAAGGAGACAA
GTAATGGCATAAGTTTGTTTTTCCCAAAGTATGCCTGTTCAATAGCCATTGGATGTGGGAAATTTCTACATCTCTTAAAATTTTACAGAA
AATACATAGCCAGATAGTCTAGCAAAAGTTCACCAAGTCCTAAATTGCTTATCCTTACTTCACTAAGTCATGAAATCATTTTAATGAAAA
GAACATCACCTAGGTTTTGTGGTTTCTTTTTTTCTTATTCATGGCTGAGTGAAAACAACAATCTCTGTTTCTCCCTAGCATCTGTGGACT
ATTTAATGTACCATTATTCCACACTCTATGGTCCTTACTAAATACAAAATTGAACAAAAAGCAGTAAAACAACTGACTCTTCACCCATAT
TATAAAATATAATCCAAGCCAGATTAGTCAACATCCATAAGATGAATCCAAGCTGAACTGGGCCTAGATTATTGAGTTCAGGTTGGATCA
CATCCCTATTTATTAATAAACTTAGGAAAGAAGGCCTTACAGACCATCAGTTAGCTGGAGCTAATAGAACCTACACTTCTAAAGTTCGGC
CTAGAATCAATGTGGCCTTAAAAGCTGAAAAGAAGCAGGAAAGAACAGTTTTCTTCAATAATTTGTCCACCCTGTCACTGGAGAAAATTT
AAGAATTTGGGGGTGTTGGTAGTAAGTTAAACACAGCAGCTGTTCATGGCAGAAATTATTCAATACATACCTTCTCTGAATATCCTATAA
CCAAAGCAAAGAAAAACACCAAGGGGTTTGTTCTCCTCCTTGGAGTTGACCTCATTCCAAGGCAGAGCTCAGGTCACAGGCACAGGGGCT
GCGCCCAAGCTTGTCCGCAGCCTTATGCAGCTGTGGAGTCTGGAAGACTGTTGCAGGACTGCTGGCCTAGTCCCAGAATGTCAGCCTCAT
TTTCGATTTACTGGCTCTTGTTGCTGTATGTCATGCTGACCTTATTGTTAAACACAGGTTTGTTTGCTTTTTTTCCACTCATGGAGACAT
GGGAGAGGCATTATTTTTAAGCTGGTTGAAAGCTTTAACCGATAAAGCATTTTTAGAGAAATGTGAATCAGGCAGCTAAGAAAGCATACT
CTGTCCATTACGGTAAAGAAAATGCACAGATTATTAACTCTGCAGTGTGGCATTAGTGTCCTGGTCAATATTCGGATAGATATGAATAAA
ATATTTAAATGGTATTGTAAATAGTTTTCAGGACATATGCTATAGCTTATTTTTATTATCTTTTGAAATTGCTCTTAATACATCAAATCC
TGATGTATTCAATTTATCAGATATAAATTATTCTAAATGAAGCCCAGTTAAATGTTTTTGTCTTGTCAGTTATATGTTAAGTTTCTGATC
TCTTTGTCTATGACGTTTACTAATCTGCATTTTTACTGTTATGAATTATTTTAGACAGCAGTGGTTTCAAGCTTTTTGCCACTAAAAATA
CCTTTTATTTTCTCCTCCCCCAGAAAAGTCTATACCTTGAAGTATCTATCCACCAAACTGTACTTCTATTAAGAAATAGTTATTGTGTTT
TCTTAATGTTTTGTTATTCAAAGACATATCAATGAAAGCTGCTGAGCAGCATGAATAACAATTATATCCACACAGATTTGATATATTTTG
TGCAGCCTTAACTTGATAGTATAAAATGTCATTGCTTTTTAAATAATAGTTAGTCAATGGACTTCTATCATAGCTTTCCTAAACTAGGTT
AAGATCCAGAGCTTTGGGGTCATAATATATTACATACAATTAAGTTATCTTTTTCTAAGGGCTTTAAAATTCATGAGAATAACCAAAAAA
GGTATGTGGAGAGTTAATACAAACATACCATATTCTTGTTGAAACAGAGATGTGGCTCTGCTTGTTCTCCATAAGGTAGAAATACTTTCC
AGAATTTGCCTAAACTAGTAAGCCCTGAATTTGCTATGATTAGGGATAGGAAGAGATTTTCACATGGCAGACTTTAGAATTCTTCACTTT
AGCCAGTAAAGTATCTCCTTTTGATCTTAGTATTCTGTGTATTTTAACTTTTCTGAGTTGTGCATGTTTATAAGAAAAATCAGCACAAAG
GGTTTAAGTTAAAGCCTTTTTACTGAAATTTGAAAGAAACAGAAGAAAATATCAAAGTTCTTTGTATTTTGAGAGGATTAAATATGATTT
ACAAAAGTTACATGGAGGGCTCTCTAAAACATTAAATTAATTATTTTTTGTTGAAAAGTCTTACTTTAGGCATCATTTTATTCCTCAGCA
ACTAGCTGTGAAGCCTTTACTGTGCTGTATGCCAGTCACTCTGCTAGATTGTGGAGATTACCAGTGTTCCCGTCTTCTCCGAGCTTAGAG
TTGGATGGGGAATAAAGACAGGTAAACAGATAGCTACAATATTGTACTGTGAATGCTTATGCTGGAGGAAGTACAGGGAACTATTGGAGC
ACCTAAGAGGAGCACCTACCTTGAATTTAGGGGTTAGCAGAGGCATCCTGAAAAAAGTCAAAGCTAAGCCACAATCTATAAGCAGTTTAG
GAATTAGCAGAACGTGCGTGGTGAGGAGATGCCAAAGGCAAGAAGAGAAGAGTATTCCAAACAGGAGGGATTCCAAAGAGAGAAGAGTAT
CCCAAACAACATTTGCACAAACCTGATGGGGAGAGAGAATGTGGGGTGGGGATGGATGATGAGACTGAAGAAGAAAGCCAGGTCTAGATA
ATCAGTGGCCTTGTACACCATGTTAAAGAGTGTAGACTTGATTCTGTTGTAAACAGGAAAGCAGCACAATTCATATGAATATTTTAGAAG
ACTCCCACTGGAATATGGAGAATAAAGTTGGAGATGACTAATCCTGGAAGCAGGGAGAACATTTTTGAGGAAGTTGCACTATTTTGGTGA
AAATGATGATCATAAACATGAAGAATTGTAGGTGATCATGACCTCCTCTCTAATTTTCCAGAAGGGTTTTGGAAGATATAACATAGGAAC
ATTGACAGGACTGACGAAAGGAGATGAAATACACCATATAAATTGTCAAACACAAGGCCAGATGTCTAATTATTTTGCTTATGTGTTGAA
ATTACAAATTTTTCATCAGGAAACCAAAAACTACAAAACTTAGTTTTCCCAAGTCCCAGAATTCTATCTGTCCAAACAATCTGTACCACT
CCACCTATATCCCTACCTTTGCATGTCTGTCCAACCTCAAAGTCCAGGTCTATACACACGGGTAAGACTAGAGCAGTTCAAGTTTCAGAA
AATGAGAAAGAGGAACTGAGTTGTGCTGAACCCATACAAAATAAACACATTCTTTGTATAGATTCTTGGAACCTCGAGAGGAATTCACCT
AACTCATAGGTATTTGATGGTATGAATCCATGGCTGGGCTCGGCTTTTAAAAAGCCTTATCTGGGATTCCTTCTATGGAACCAAGTTCCA
TCAAAGCCCATTTAAAAGCCTACATTAAAAACAAAATTCTTGCTGCATTGTATACAAATAATGATGTCATGATCAAATAATCAGATGCCA
TTATCAAGTGGAATTACAAAATGGTATACCCACTCCAAAAAAAAAAAAAAAGCTAAATTCTCAGTAGAACATTGTGACTTCATGAGCCCT
CCACAGCCTTGGAGCTGAGGAGGGAGCACTGGTGAGCAGTAGGTTGAAGAGAAAACTTGGCGCTTAATAATCTATCCATGTTTTTTCATC
TAAAAGAGCCTTCTTTTTGGATTACCTTATTCAATTTCCATCAAGGAAATTGTTAGTTCCACTAACCAGACAGCAGCTGGGAAGGCAGAA
GCTTACTGTATGTACATGGTAGCTGTGGGAAGGAGGTTTCTTTCTCCAGGTCCTCACTGGCCATACACCAGTCCCTTGTTAGTTATGCCT
GGTCATAGACCCCCGTTGCTATCATCTCATATTTAAGTCTTTGGCTTGTGAATTTATCTATTCTTTCAGCTTCAGCACTGCAGAGTGCTG
GGACTTTGCTAACTTCCATTTCTTGCTGGCTTAGCACATTCCTCATAGGCCCAGCTCTTTTCTCATCTGGCCCTGCTGTGGAGTCACCTT
GCCCCTTCAGGAGAGCCATGGCTTACCACTGCCTGCTAAGCCTCCACTCAGCTGCCACCACACTAAATCCAAGCTTCTCTAAGATGTTGC
AGACTTTACAGGCAAGCATAAAAGGCTTGATCTTCCTGGACTTCCCTTTACTTGTCTGAATCTCACCTCCTTCAACTTTCAGTCTCAGAA
TGTAGGCATTTGTCCTCTTTGCCCTACATCTTCCTTCTTCTGAATCATGAAAGCCTCTCACTTCCTCTTGCTATGTGCTGGAGGCTTCTG
TCAGGTTTTAGAATGAGTTCTCATCTAGTCCTAGTAGCTTTTGATGCTTAAGTCCACCTTTTAAGGATACCTTTGAGATTTAGACCATGT
TTTTCGCTTGAGAAAGCCCTAATCTCCAGACTTGCCTTTCTGTGGATTTCAAAGACCAACTGAGGAAGTCAAAAGCTGAATGTTGACTTT
CTTTGAACATTTCCGCTATAACAATTCCAATTCTCCTCAGAGCAATATGCCTGCCTCCAACTGACCAGGAGAAAGGTCCAGTGCCAAAGA
GAAAAACACAAAGATTAATTATTTCAGTTGAGCACATACTTTCAAAGTGGTTTGGGTATTCATATGAGGTTTTCTGTCAAGAGGGTGAGA
CTCTTCATCTATCCATGTGTGCCTGACAGTTCTCCTGGCACTGGCTGGTAACAGATGCAAAACTGTAAAAATTAAGTGATCATGTATTTT
AACGATATCATCACATACTTATTTTCTATGTAATGTTTTAAATTTCCCCTAACATACTTTGACTGTTTTGCACATGGTAGATATTCACAT
TTTTTTGTGTTGAAGTTGATGCAATCTTCAAAGTTATCTACCCCGTTGCTTATTAGTAAAACTAGTGTTAATACTTGGCAAGAGATGCAG
GGAATCTTTCTCATGACTCACGCCCTATTTAGTTATTAATGCTACTACCCTATTTTGAGTAAGTAGTAGGTCCCTAAGTACATTGTCCAG
AGTTATACTTTTAAAGATATTTAGCCCCATATACTTCTTGAATCTAAAGTCATACACCTTGCTCCTCATTTCTGAGTGGGAAAGACATTT
GAGAGTATGTTGACAATTGTTCTGAAGGTTTTTGCCAAGAAGGTGAAACTGTCCTTTCATCTGTGTATGCCTGGGGCTGGGTCCCTGGCA
GTGATGGGGTGACAATGCAAAGCTGTAAAAACTAGGTGCTAGTGGGCACCTAATATCATCATCATATACTTATTTTCAAGCTAATATGCA
AAATCCCATCTCTGTTTTTAAACTAAGTGTAGATTTCAGAGAAAATATTTTGTGGTTCACATAAGAAAACAGTCTACTCAGCTTGACAAG
TGTTTTATGTTAAATTGGCTGGTGGTTTGAAATGAATCATCTTCACATAATGTTTTCTTTAAAAATATTGTGAATTTAACTCTAATTCTT

>In-frame_ENST00000524892_ENST00000325455_TCGA-A1-A0SJ-01A_ARHGAP42_chr11_100558563_+_PGR_chr11_100933483_length(amino acids)=349AA_start in transcript=26_stop in transcript=1075
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRSRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFT
FSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLG
WRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIK

--------------------------------------------------------------
>In-frame_ENST00000524892_ENST00000534013_TCGA-A1-A0SJ-01A_ARHGAP42_chr11_100558563_+_PGR_chr11_100933483_length(transcript)=1512nt_BP=180nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
GTCGAAAATTTAAAAAGTTCAATAAAGTCAGAGTTGTGAGAGCACTGGATGCTGTTGCTCTCCCACAGCCAGTGGGCGTTCCAAATGAAA
GCCAAGCCCTAAGCCAGAGATTCACTTTTTCACCAGGTCAAGACATACAGTTGATTCCACCACTGATCAACCTGTTAATGAGCATTGAAC
CAGATGTGATCTATGCAGGACATGACAACACAAAACCTGACACCTCCAGTTCTTTGCTGACAAGTCTTAATCAACTAGGCGAGAGGCAAC
TTCTTTCAGTAGTCAAGTGGTCTAAATCATTGCCAGGTTTTCGAAACTTACATATTGATGACCAGATAACTCTCATTCAGTATTCTTGGA
TGAGCTTAATGGTGTTTGGTCTAGGATGGAGATCCTACAAACACGTCAGTGGGCAGATGCTGTATTTTGCACCTGATCTAATACTAAATG
AACAGCGGATGAAAGAATCATCATTCTATTCATTATGCCTTACCATGTGGCAGATCCCACAGGAGTTTGTCAAGCTTCAAGTTAGCCAAG
AAGAGTTCCTCTGTATGAAAGTATTGTTACTTCTTAATACAATTCCTTTGGAAGGGCTACGAAGTCAAACCCAGTTTGAGGAGATGAGGT
CAAGCTACATTAGAGAGCTCATCAAGGCAATTGGTTTGAGGCAAAAAGGAGTTGTGTCGAGCTCACAGCGTTTCTATCAACTTACAAAAC
TTCTTGATAACTTGCATGATCTTGTCAAACAACTTCATCTGTACTGCTTGAATACATTTATCCAGTCCCGGGCACTGAGTGTTGAATTTC
CAGAAATGATGTCTGAAGTTATTGCTGCACAATTACCCAAGATATTGGCAGGGATGGTGAAACCCCTTCTCTTTCATAAAAAGTGAATGT
CATCTTTTTCTTTTAAAGAATTAAATTTTGTGGTATGTCTTTTTGTTTTGGTCAGGATTATGAGGTCTTGAGTTTTTATAATGTTCTTCT
GAAAGCCTTACATTTATAACATCATAGTGTGTAAATTTAAAAGAAAAATTGTGAGGTTCTAATTATTTTCTTTTATAAAGTATAATTAGA
ATGTTTAACTGTTTTGTTTACCCATATTTTCTTGAAGAATTTACAAGATTGAAAAAGTACTAAAATTGTTAAAGTAAACTATCTTATCCA
TATTATTTCATACCATGTAGGTGAGGATTTTTAACTTTTGCATCTAACAAATCATCGACTTAAGAGAAAAAATCTTACATGTAATAACAC

>In-frame_ENST00000524892_ENST00000534013_TCGA-A1-A0SJ-01A_ARHGAP42_chr11_100558563_+_PGR_chr11_100933483_length(amino acids)=349AA_start in transcript=26_stop in transcript=1075
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRSRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFT
FSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLG
WRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIK

--------------------------------------------------------------
>In-frame_ENST00000298815_ENST00000325455_TCGA-A1-A0SJ-01A_ARHGAP42_chr11_100558563_+_PGR_chr11_100933483_length(transcript)=10545nt_BP=157nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAGTCGAAAATTTAAAAAGTTCAAT
AAAGTCAGAGTTGTGAGAGCACTGGATGCTGTTGCTCTCCCACAGCCAGTGGGCGTTCCAAATGAAAGCCAAGCCCTAAGCCAGAGATTC
ACTTTTTCACCAGGTCAAGACATACAGTTGATTCCACCACTGATCAACCTGTTAATGAGCATTGAACCAGATGTGATCTATGCAGGACAT
GACAACACAAAACCTGACACCTCCAGTTCTTTGCTGACAAGTCTTAATCAACTAGGCGAGAGGCAACTTCTTTCAGTAGTCAAGTGGTCT
AAATCATTGCCAGGTTTTCGAAACTTACATATTGATGACCAGATAACTCTCATTCAGTATTCTTGGATGAGCTTAATGGTGTTTGGTCTA
GGATGGAGATCCTACAAACACGTCAGTGGGCAGATGCTGTATTTTGCACCTGATCTAATACTAAATGAACAGCGGATGAAAGAATCATCA
TTCTATTCATTATGCCTTACCATGTGGCAGATCCCACAGGAGTTTGTCAAGCTTCAAGTTAGCCAAGAAGAGTTCCTCTGTATGAAAGTA
TTGTTACTTCTTAATACAATTCCTTTGGAAGGGCTACGAAGTCAAACCCAGTTTGAGGAGATGAGGTCAAGCTACATTAGAGAGCTCATC
AAGGCAATTGGTTTGAGGCAAAAAGGAGTTGTGTCGAGCTCACAGCGTTTCTATCAACTTACAAAACTTCTTGATAACTTGCATGATCTT
GTCAAACAACTTCATCTGTACTGCTTGAATACATTTATCCAGTCCCGGGCACTGAGTGTTGAATTTCCAGAAATGATGTCTGAAGTTATT
GCTGCACAATTACCCAAGATATTGGCAGGGATGGTGAAACCCCTTCTCTTTCATAAAAAGTGAATGTCATCTTTTTCTTTTAAAGAATTA
AATTTTGTGGTATGTCTTTTTGTTTTGGTCAGGATTATGAGGTCTTGAGTTTTTATAATGTTCTTCTGAAAGCCTTACATTTATAACATC
ATAGTGTGTAAATTTAAAAGAAAAATTGTGAGGTTCTAATTATTTTCTTTTATAAAGTATAATTAGAATGTTTAACTGTTTTGTTTACCC
ATATTTTCTTGAAGAATTTACAAGATTGAAAAAGTACTAAAATTGTTAAAGTAAACTATCTTATCCATATTATTTCATACCATGTAGGTG
AGGATTTTTAACTTTTGCATCTAACAAATCATCGACTTAAGAGAAAAAATCTTACATGTAATAACACAAAGCTATTATATGTTATTTCTA
GGTAACTCCCTTTGTGTCAATTATATTTCCAAAAATGAACCTTTAAAATGGTATGCAAAATTTTGTCTATATATATTTGTGTGAGGAGGA
AATTCATAACTTTCCTCAGATTTTCAAAAGTATTTTTAATGCAAAAAATGTAGAAAGAGTTTAAAACCACTAAAATAGATTGATGTTCTT
CAAACTAGGCAAAACAACTCATATGTTAAGACCATTTTCCAGATTGGAAACACAAATCTCTTAGGAAGTTAATAAGTAGATTCATATCAT
TATGCAAATAGTATTGTGGGTTTTGTAGGTTTTTAAAATAACCTTTTTTGGGGAGAGAATTGTCCTCTAATGAGGTATTGCGAGTGGACA
TAAGAAATCAGAAGATTATGGCCTAACTGTACTCCTTACCAACTGTGGCATGCTGAAAGTTAGTCACTCTTACTGATTCTCAATTCTCTC
ACCTTTGAAAGTAGTAAAATATCTTTCCTGCCAATTGCTCCTTTGGGTCAGAGCTTATTAACATCTTTTCAAATCAAAGGAAAGAAGAAA
GGGAGAGGAGGAGGAGGGAGGTATCAATTCACATACCTTTCTCCTCTTTATCCTCCACTATCATGAATTCATATTATGTTTCAGCCATGC
AAATCTTTTTACCATGAAATTTCTTCCAGAATTTTCCCCCTTTGACACAAATTCCATGCATGTTTCAACCTTCGAGACTCAGCCAAATGT
CATTTCTGTAAAATCTTCCCTGAGTCTTCCAAGCAGTAATTTGCCTTCTCCTAGAGTTTACCTGCCATTTTGTGCACATTTGAGTTACAG
TAGCATGTTATTTTACAATTGTGACTCTCCTGGGAGTCTGGGAGCCATATAAAGTGGTCAATAGTGTTTGCTGACTGAGAGTTGAATGAC
ATTTTCTCTCTGTCTTGGTATTACTGTAGATTTCGATCATTCTTTGGTTACATTTCTGCATATTTCTGTACCCATGACTTTATCACTTTC
TTCTCCCATGCTTTATCTCCATCAATTATCTTCATTACTTTTAAATTTTCCACCTTTGCTTCCTACTTTGTGAGATCTCTCCCTTTACTG
ACTATAACATAGAAGAATAGAAGTGTATTTTATGTGTCTTAAGGACAATACTTTAGATTCCTTGTTCTAAGTTTTTAAACTGAATGAATG
GAATATTATTTCTCTCCCTAAGCAAAATTCCACAAAACAATTATTTCTTATGTTTATGTAGCCTTAAATTGTTTTGTACTGTAAACCTCA
GCATAAAAACTTTCTTCATTTCTAATTTCATTCAACAAATATTGATTGAATACCTGGTATTAGCACAAGAAAAATGTGCTAATAAGCCTT
ATGAGAATTTGGAGCTGAAGAAAGACATATAACTCAGGAAAGTTACAGTCCAGTAGTAGGTATAAATTACAGTGCCTGATAAATAGGCAT
TTTAATATTTGTACACTCAACGTATACTAGGTAGGTGCAAAACATTTACATATAATTTTACTGATACCCATGCAGCACAAAGGTACTAAC
TTTAAATATTAAATAACACCTTTATGTGTCAGTAATTCATTTGCATTAAATCTTATTGAAAAGGCTTTCAATATATTTTCCCCACAAATG
TCATCCCAAGAAAAAAGTATTTTTAACATCTCCCAAATATAATAGTTACAGGAAATCTACCTCTGTGAGAGTGACACCTCTCAGAATGAA
CTGTGTGACACAAGAAAATGAATGTAGGTCTATCCAAAAAAAACCCCAAGAAACAAAAACAATATTATTAGCCCTTTATGCTTAAGTGAT
GGACTCAGGGAACAGTTGATGTTGTGATCATTTTATTATCTGATTCTTGTTACTTTGAATTAAACCAATATTTTGATGATATAAATCATT
TCCACCAGCATATATTTAATTTCCATAATAACTTTAAAATTTTCTAATTTCACTCAACTATGAGGGAATAGAATGTGGTGGCCACAGGTT
TGGCTTTTGTTAAAATGTTTGATATCTTCGATGTTGATCTCTGTCTGCAATGTAGATGTCTAAACACTAGGATTTAATATTTAAGGCTAA
GCTTTAAAAATAAAGTACCTTTTTAAAAAGAATATGGCTTCACCAAATGGAAAATACCTAATTTCTAAATCTTTTTCTCTACAAAGTCCT
ATCTACTAATGTCTCCATTACTATTTAGTCATCATAACCATTATCTTCATTTTACATGTCGTGTTCTTTCTGGTAGCTCTAAAATGACAC
TAAATCATAAGAAGACAGGTTACATATCAGGAAATACTTGAAGGTTACTGAAATAGATTCTTGAGTTAATGAAAATATTTTCTGTAAAAA
GGTTTGAAAAGCCATTTGAGTCTAAAGCATTATACCTCCATTATCAGTAGTTATGTGACAATTGTGTGTGTGTTTAATGTTTAAAGATGT
GGCACTTTTTAATAAGGCAATGCTATGCTATTTTTTCCCATTTAACATTAAGATAATTTATTGCTATACAGATGATATGGAAATATGATG
AACAATATTTTTTTTGCCAAAACTATGCCTTGTAAGTAGCCATGGAATGTCAACCTGTAACTTAAATTATCCACAGATAGTCATGTGTTT
GATGATGGGCACTGTGGAGATAACTGACATAGGACTGTGCCCCCCTTCTCTGCCACTTACTAGCTGGATGAGATTAAGCAAGTCATTTAA
CTGCTCTGATTAAACCTGCCTTTCCCAAGTGCTTTGTAATGAATAGAAATGGAAACCAAAAAAAACGTATACAGGCCTTCAGAAATAGTA
ATTGCTACTATTTTGTTTTCATTAAGCCATAGTTCTGGCTATAATTTTATCAAACTCACCAGCTATATTCTACAGTGAAAGCAGGATTCT
AGAAAGTCTCACTGTTTTATTTATGTCACCATGTGCTATGATATATTTGGTTGAATTCATTTGAAATTAGGGCTGGAAGTATTCAAGTAA
TTTCTTCTGCTGAAAAAATACAGTGTTTTGAGTTTAGGGCCTGTTTTATCAAAGTTCTAAAGAGCCTATCACTCTTCCATTGTAGACATT
TTAAAATAATGACACTGATTTTAACATTTTTAAGTGTCTTTTTAGAACAGAGAGCCTGACTAGAACACAGCCCCTCCAAAAACCCATGCT
CAAATTATTTTTACTATGGCAGCAATTCCACAAAAGGGAACAATGGGTTTAGAAATTACAATGAAGTCATCAACCCAAAAAACATCCCTA
TCCCTAAGAAGGTTATGATATAAAATGCCCACAAGAAATCTATGTCTGCTTTAATCTGTCTTTTATTGCTTTGGAAGGATGGCTATTACA
TTTTTAGTTTTTGCTGTGAATACCTGAGCAGTTTCTCTCATCCATACTTATCCTTCACACATCAGAAGTCAGGATAGAATATGAATCATT
TTAAAAACTTTTACAACTCCAGAGCCATGTGCATAAGAAGCATTCAAAACTTGCCAAAACATACATTTTTTTTCAAATTTAAAGATACTC
TATTTTTGTATTCAATAGCTCAACAACTGTGGTCCCCACTGATAAAGTGAAGTGGACAAGGAGACAAGTAATGGCATAAGTTTGTTTTTC
CCAAAGTATGCCTGTTCAATAGCCATTGGATGTGGGAAATTTCTACATCTCTTAAAATTTTACAGAAAATACATAGCCAGATAGTCTAGC
AAAAGTTCACCAAGTCCTAAATTGCTTATCCTTACTTCACTAAGTCATGAAATCATTTTAATGAAAAGAACATCACCTAGGTTTTGTGGT
TTCTTTTTTTCTTATTCATGGCTGAGTGAAAACAACAATCTCTGTTTCTCCCTAGCATCTGTGGACTATTTAATGTACCATTATTCCACA
CTCTATGGTCCTTACTAAATACAAAATTGAACAAAAAGCAGTAAAACAACTGACTCTTCACCCATATTATAAAATATAATCCAAGCCAGA
TTAGTCAACATCCATAAGATGAATCCAAGCTGAACTGGGCCTAGATTATTGAGTTCAGGTTGGATCACATCCCTATTTATTAATAAACTT
AGGAAAGAAGGCCTTACAGACCATCAGTTAGCTGGAGCTAATAGAACCTACACTTCTAAAGTTCGGCCTAGAATCAATGTGGCCTTAAAA
GCTGAAAAGAAGCAGGAAAGAACAGTTTTCTTCAATAATTTGTCCACCCTGTCACTGGAGAAAATTTAAGAATTTGGGGGTGTTGGTAGT
AAGTTAAACACAGCAGCTGTTCATGGCAGAAATTATTCAATACATACCTTCTCTGAATATCCTATAACCAAAGCAAAGAAAAACACCAAG
GGGTTTGTTCTCCTCCTTGGAGTTGACCTCATTCCAAGGCAGAGCTCAGGTCACAGGCACAGGGGCTGCGCCCAAGCTTGTCCGCAGCCT
TATGCAGCTGTGGAGTCTGGAAGACTGTTGCAGGACTGCTGGCCTAGTCCCAGAATGTCAGCCTCATTTTCGATTTACTGGCTCTTGTTG
CTGTATGTCATGCTGACCTTATTGTTAAACACAGGTTTGTTTGCTTTTTTTCCACTCATGGAGACATGGGAGAGGCATTATTTTTAAGCT
GGTTGAAAGCTTTAACCGATAAAGCATTTTTAGAGAAATGTGAATCAGGCAGCTAAGAAAGCATACTCTGTCCATTACGGTAAAGAAAAT
GCACAGATTATTAACTCTGCAGTGTGGCATTAGTGTCCTGGTCAATATTCGGATAGATATGAATAAAATATTTAAATGGTATTGTAAATA
GTTTTCAGGACATATGCTATAGCTTATTTTTATTATCTTTTGAAATTGCTCTTAATACATCAAATCCTGATGTATTCAATTTATCAGATA
TAAATTATTCTAAATGAAGCCCAGTTAAATGTTTTTGTCTTGTCAGTTATATGTTAAGTTTCTGATCTCTTTGTCTATGACGTTTACTAA
TCTGCATTTTTACTGTTATGAATTATTTTAGACAGCAGTGGTTTCAAGCTTTTTGCCACTAAAAATACCTTTTATTTTCTCCTCCCCCAG
AAAAGTCTATACCTTGAAGTATCTATCCACCAAACTGTACTTCTATTAAGAAATAGTTATTGTGTTTTCTTAATGTTTTGTTATTCAAAG
ACATATCAATGAAAGCTGCTGAGCAGCATGAATAACAATTATATCCACACAGATTTGATATATTTTGTGCAGCCTTAACTTGATAGTATA
AAATGTCATTGCTTTTTAAATAATAGTTAGTCAATGGACTTCTATCATAGCTTTCCTAAACTAGGTTAAGATCCAGAGCTTTGGGGTCAT
AATATATTACATACAATTAAGTTATCTTTTTCTAAGGGCTTTAAAATTCATGAGAATAACCAAAAAAGGTATGTGGAGAGTTAATACAAA
CATACCATATTCTTGTTGAAACAGAGATGTGGCTCTGCTTGTTCTCCATAAGGTAGAAATACTTTCCAGAATTTGCCTAAACTAGTAAGC
CCTGAATTTGCTATGATTAGGGATAGGAAGAGATTTTCACATGGCAGACTTTAGAATTCTTCACTTTAGCCAGTAAAGTATCTCCTTTTG
ATCTTAGTATTCTGTGTATTTTAACTTTTCTGAGTTGTGCATGTTTATAAGAAAAATCAGCACAAAGGGTTTAAGTTAAAGCCTTTTTAC
TGAAATTTGAAAGAAACAGAAGAAAATATCAAAGTTCTTTGTATTTTGAGAGGATTAAATATGATTTACAAAAGTTACATGGAGGGCTCT
CTAAAACATTAAATTAATTATTTTTTGTTGAAAAGTCTTACTTTAGGCATCATTTTATTCCTCAGCAACTAGCTGTGAAGCCTTTACTGT
GCTGTATGCCAGTCACTCTGCTAGATTGTGGAGATTACCAGTGTTCCCGTCTTCTCCGAGCTTAGAGTTGGATGGGGAATAAAGACAGGT
AAACAGATAGCTACAATATTGTACTGTGAATGCTTATGCTGGAGGAAGTACAGGGAACTATTGGAGCACCTAAGAGGAGCACCTACCTTG
AATTTAGGGGTTAGCAGAGGCATCCTGAAAAAAGTCAAAGCTAAGCCACAATCTATAAGCAGTTTAGGAATTAGCAGAACGTGCGTGGTG
AGGAGATGCCAAAGGCAAGAAGAGAAGAGTATTCCAAACAGGAGGGATTCCAAAGAGAGAAGAGTATCCCAAACAACATTTGCACAAACC
TGATGGGGAGAGAGAATGTGGGGTGGGGATGGATGATGAGACTGAAGAAGAAAGCCAGGTCTAGATAATCAGTGGCCTTGTACACCATGT
TAAAGAGTGTAGACTTGATTCTGTTGTAAACAGGAAAGCAGCACAATTCATATGAATATTTTAGAAGACTCCCACTGGAATATGGAGAAT
AAAGTTGGAGATGACTAATCCTGGAAGCAGGGAGAACATTTTTGAGGAAGTTGCACTATTTTGGTGAAAATGATGATCATAAACATGAAG
AATTGTAGGTGATCATGACCTCCTCTCTAATTTTCCAGAAGGGTTTTGGAAGATATAACATAGGAACATTGACAGGACTGACGAAAGGAG
ATGAAATACACCATATAAATTGTCAAACACAAGGCCAGATGTCTAATTATTTTGCTTATGTGTTGAAATTACAAATTTTTCATCAGGAAA
CCAAAAACTACAAAACTTAGTTTTCCCAAGTCCCAGAATTCTATCTGTCCAAACAATCTGTACCACTCCACCTATATCCCTACCTTTGCA
TGTCTGTCCAACCTCAAAGTCCAGGTCTATACACACGGGTAAGACTAGAGCAGTTCAAGTTTCAGAAAATGAGAAAGAGGAACTGAGTTG
TGCTGAACCCATACAAAATAAACACATTCTTTGTATAGATTCTTGGAACCTCGAGAGGAATTCACCTAACTCATAGGTATTTGATGGTAT
GAATCCATGGCTGGGCTCGGCTTTTAAAAAGCCTTATCTGGGATTCCTTCTATGGAACCAAGTTCCATCAAAGCCCATTTAAAAGCCTAC
ATTAAAAACAAAATTCTTGCTGCATTGTATACAAATAATGATGTCATGATCAAATAATCAGATGCCATTATCAAGTGGAATTACAAAATG
GTATACCCACTCCAAAAAAAAAAAAAAAGCTAAATTCTCAGTAGAACATTGTGACTTCATGAGCCCTCCACAGCCTTGGAGCTGAGGAGG
GAGCACTGGTGAGCAGTAGGTTGAAGAGAAAACTTGGCGCTTAATAATCTATCCATGTTTTTTCATCTAAAAGAGCCTTCTTTTTGGATT
ACCTTATTCAATTTCCATCAAGGAAATTGTTAGTTCCACTAACCAGACAGCAGCTGGGAAGGCAGAAGCTTACTGTATGTACATGGTAGC
TGTGGGAAGGAGGTTTCTTTCTCCAGGTCCTCACTGGCCATACACCAGTCCCTTGTTAGTTATGCCTGGTCATAGACCCCCGTTGCTATC
ATCTCATATTTAAGTCTTTGGCTTGTGAATTTATCTATTCTTTCAGCTTCAGCACTGCAGAGTGCTGGGACTTTGCTAACTTCCATTTCT
TGCTGGCTTAGCACATTCCTCATAGGCCCAGCTCTTTTCTCATCTGGCCCTGCTGTGGAGTCACCTTGCCCCTTCAGGAGAGCCATGGCT
TACCACTGCCTGCTAAGCCTCCACTCAGCTGCCACCACACTAAATCCAAGCTTCTCTAAGATGTTGCAGACTTTACAGGCAAGCATAAAA
GGCTTGATCTTCCTGGACTTCCCTTTACTTGTCTGAATCTCACCTCCTTCAACTTTCAGTCTCAGAATGTAGGCATTTGTCCTCTTTGCC
CTACATCTTCCTTCTTCTGAATCATGAAAGCCTCTCACTTCCTCTTGCTATGTGCTGGAGGCTTCTGTCAGGTTTTAGAATGAGTTCTCA
TCTAGTCCTAGTAGCTTTTGATGCTTAAGTCCACCTTTTAAGGATACCTTTGAGATTTAGACCATGTTTTTCGCTTGAGAAAGCCCTAAT
CTCCAGACTTGCCTTTCTGTGGATTTCAAAGACCAACTGAGGAAGTCAAAAGCTGAATGTTGACTTTCTTTGAACATTTCCGCTATAACA
ATTCCAATTCTCCTCAGAGCAATATGCCTGCCTCCAACTGACCAGGAGAAAGGTCCAGTGCCAAAGAGAAAAACACAAAGATTAATTATT
TCAGTTGAGCACATACTTTCAAAGTGGTTTGGGTATTCATATGAGGTTTTCTGTCAAGAGGGTGAGACTCTTCATCTATCCATGTGTGCC
TGACAGTTCTCCTGGCACTGGCTGGTAACAGATGCAAAACTGTAAAAATTAAGTGATCATGTATTTTAACGATATCATCACATACTTATT
TTCTATGTAATGTTTTAAATTTCCCCTAACATACTTTGACTGTTTTGCACATGGTAGATATTCACATTTTTTTGTGTTGAAGTTGATGCA
ATCTTCAAAGTTATCTACCCCGTTGCTTATTAGTAAAACTAGTGTTAATACTTGGCAAGAGATGCAGGGAATCTTTCTCATGACTCACGC
CCTATTTAGTTATTAATGCTACTACCCTATTTTGAGTAAGTAGTAGGTCCCTAAGTACATTGTCCAGAGTTATACTTTTAAAGATATTTA
GCCCCATATACTTCTTGAATCTAAAGTCATACACCTTGCTCCTCATTTCTGAGTGGGAAAGACATTTGAGAGTATGTTGACAATTGTTCT
GAAGGTTTTTGCCAAGAAGGTGAAACTGTCCTTTCATCTGTGTATGCCTGGGGCTGGGTCCCTGGCAGTGATGGGGTGACAATGCAAAGC
TGTAAAAACTAGGTGCTAGTGGGCACCTAATATCATCATCATATACTTATTTTCAAGCTAATATGCAAAATCCCATCTCTGTTTTTAAAC
TAAGTGTAGATTTCAGAGAAAATATTTTGTGGTTCACATAAGAAAACAGTCTACTCAGCTTGACAAGTGTTTTATGTTAAATTGGCTGGT
GGTTTGAAATGAATCATCTTCACATAATGTTTTCTTTAAAAATATTGTGAATTTAACTCTAATTCTTGTTATTCTGTGTGATAATAAAGA

>In-frame_ENST00000298815_ENST00000325455_TCGA-A1-A0SJ-01A_ARHGAP42_chr11_100558563_+_PGR_chr11_100933483_length(amino acids)=349AA_start in transcript=3_stop in transcript=1052
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRSRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFT
FSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLG
WRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIK

--------------------------------------------------------------
>In-frame_ENST00000298815_ENST00000534013_TCGA-A1-A0SJ-01A_ARHGAP42_chr11_100558563_+_PGR_chr11_100933483_length(transcript)=1489nt_BP=157nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAGTCGAAAATTTAAAAAGTTCAAT
AAAGTCAGAGTTGTGAGAGCACTGGATGCTGTTGCTCTCCCACAGCCAGTGGGCGTTCCAAATGAAAGCCAAGCCCTAAGCCAGAGATTC
ACTTTTTCACCAGGTCAAGACATACAGTTGATTCCACCACTGATCAACCTGTTAATGAGCATTGAACCAGATGTGATCTATGCAGGACAT
GACAACACAAAACCTGACACCTCCAGTTCTTTGCTGACAAGTCTTAATCAACTAGGCGAGAGGCAACTTCTTTCAGTAGTCAAGTGGTCT
AAATCATTGCCAGGTTTTCGAAACTTACATATTGATGACCAGATAACTCTCATTCAGTATTCTTGGATGAGCTTAATGGTGTTTGGTCTA
GGATGGAGATCCTACAAACACGTCAGTGGGCAGATGCTGTATTTTGCACCTGATCTAATACTAAATGAACAGCGGATGAAAGAATCATCA
TTCTATTCATTATGCCTTACCATGTGGCAGATCCCACAGGAGTTTGTCAAGCTTCAAGTTAGCCAAGAAGAGTTCCTCTGTATGAAAGTA
TTGTTACTTCTTAATACAATTCCTTTGGAAGGGCTACGAAGTCAAACCCAGTTTGAGGAGATGAGGTCAAGCTACATTAGAGAGCTCATC
AAGGCAATTGGTTTGAGGCAAAAAGGAGTTGTGTCGAGCTCACAGCGTTTCTATCAACTTACAAAACTTCTTGATAACTTGCATGATCTT
GTCAAACAACTTCATCTGTACTGCTTGAATACATTTATCCAGTCCCGGGCACTGAGTGTTGAATTTCCAGAAATGATGTCTGAAGTTATT
GCTGCACAATTACCCAAGATATTGGCAGGGATGGTGAAACCCCTTCTCTTTCATAAAAAGTGAATGTCATCTTTTTCTTTTAAAGAATTA
AATTTTGTGGTATGTCTTTTTGTTTTGGTCAGGATTATGAGGTCTTGAGTTTTTATAATGTTCTTCTGAAAGCCTTACATTTATAACATC
ATAGTGTGTAAATTTAAAAGAAAAATTGTGAGGTTCTAATTATTTTCTTTTATAAAGTATAATTAGAATGTTTAACTGTTTTGTTTACCC
ATATTTTCTTGAAGAATTTACAAGATTGAAAAAGTACTAAAATTGTTAAAGTAAACTATCTTATCCATATTATTTCATACCATGTAGGTG
AGGATTTTTAACTTTTGCATCTAACAAATCATCGACTTAAGAGAAAAAATCTTACATGTAATAACACAAAGCTATTATATGTTATTTCTA

>In-frame_ENST00000298815_ENST00000534013_TCGA-A1-A0SJ-01A_ARHGAP42_chr11_100558563_+_PGR_chr11_100933483_length(amino acids)=349AA_start in transcript=3_stop in transcript=1052
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRSRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFT
FSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLG
WRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIK

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Fusion Gene PPI Analysis for ARHGAP42-PGR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP42-PGR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP42-PGR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePGRC0025286Meningioma3CTD_human
TgenePGRC0205834Meningiomas, Multiple3CTD_human
TgenePGRC0259785Malignant Meningioma3CTD_human
TgenePGRC0281784Benign Meningioma3CTD_human
TgenePGRC0334605Meningothelial meningioma3CTD_human
TgenePGRC0334606Fibrous Meningioma3CTD_human
TgenePGRC0334607Psammomatous Meningioma3CTD_human
TgenePGRC0334608Angiomatous Meningioma3CTD_human
TgenePGRC0334609Hemangioblastic Meningioma3CTD_human
TgenePGRC0334610Hemangiopericytic Meningioma3CTD_human
TgenePGRC0334611Transitional Meningioma3CTD_human
TgenePGRC0347515Spinal Meningioma3CTD_human
TgenePGRC0349604Intracranial Meningioma3CTD_human
TgenePGRC0431121Clear Cell Meningioma3CTD_human
TgenePGRC0457190Xanthomatous Meningioma3CTD_human
TgenePGRC0751303Cerebral Convexity Meningioma3CTD_human
TgenePGRC0751304Parasagittal Meningioma3CTD_human
TgenePGRC1334261Intraorbital Meningioma3CTD_human
TgenePGRC1334271Intraventricular Meningioma3CTD_human
TgenePGRC1335107Olfactory Groove Meningioma3CTD_human
TgenePGRC1384406Secretory meningioma3CTD_human
TgenePGRC1384408Microcystic meningioma3CTD_human
TgenePGRC1527197Angioblastic Meningioma3CTD_human
TgenePGRC1565950Posterior Fossa Meningioma3CTD_human
TgenePGRC1565951Sphenoid Wing Meningioma3CTD_human
TgenePGRC3163622Papillary Meningioma3CTD_human
TgenePGRC0006142Malignant neoplasm of breast2CTD_human
TgenePGRC0014175Endometriosis2CTD_human
TgenePGRC0269102Endometrioma2CTD_human
TgenePGRC0678222Breast Carcinoma2CTD_human
TgenePGRC1257931Mammary Neoplasms, Human2CTD_human
TgenePGRC1458155Mammary Neoplasms2CTD_human
TgenePGRC4704874Mammary Carcinoma, Human2CTD_human
TgenePGRC0001418Adenocarcinoma1CTD_human
TgenePGRC0007097Carcinoma1CTD_human
TgenePGRC0014170Endometrial Neoplasms1CTD_human
TgenePGRC0024667Animal Mammary Neoplasms1CTD_human
TgenePGRC0024668Mammary Neoplasms, Experimental1CTD_human
TgenePGRC0025500Mesothelioma1CTD_human
TgenePGRC0205641Adenocarcinoma, Basal Cell1CTD_human
TgenePGRC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgenePGRC0205643Carcinoma, Cribriform1CTD_human
TgenePGRC0205644Carcinoma, Granular Cell1CTD_human
TgenePGRC0205645Adenocarcinoma, Tubular1CTD_human
TgenePGRC0205696Anaplastic carcinoma1CTD_human
TgenePGRC0205697Carcinoma, Spindle-Cell1CTD_human
TgenePGRC0205698Undifferentiated carcinoma1CTD_human
TgenePGRC0205699Carcinomatosis1CTD_human
TgenePGRC0476089Endometrial Carcinoma1CTD_human
TgenePGRC1257925Mammary Carcinoma, Animal1CTD_human