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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:PAPOLG-ABCA12 (FusionGDB2 ID:62221) |
Fusion Gene Summary for PAPOLG-ABCA12 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PAPOLG-ABCA12 | Fusion gene ID: 62221 | Hgene | Tgene | Gene symbol | PAPOLG | ABCA12 | Gene ID | 64895 | 26154 |
Gene name | poly(A) polymerase gamma | ATP binding cassette subfamily A member 12 | |
Synonyms | - | ARCI4A|ARCI4B|ICR2B|LI2 | |
Cytomap | 2p16.1 | 2q35 | |
Type of gene | protein-coding | protein-coding | |
Description | poly(A) polymerase gammaPAP-gammaSRP RNA 3' adenylating enzyme/pap2SRP RNA 3'-adenylating enzymeSRP RNA-adenylating enzymeneo-PAPneo-poly(A) polymerasenuclear poly(A) polymerase gammapolynucleotide adenylyltransferase gammasignal recognition part | ATP-binding cassette sub-family A member 12ATP-binding cassette transporter 12ATP-binding cassette, sub-family A (ABC1), member 12 | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | . | Q86UK0 | |
Ensembl transtripts involved in fusion gene | ENST00000238714, ENST00000483370, | ENST00000272895, ENST00000389661, ENST00000412081, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 6 X 4=120 |
# samples | 3 | 5 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PAPOLG [Title/Abstract] AND ABCA12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | PAPOLG(60997646)-ABCA12(215821502), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PAPOLG | GO:0043631 | RNA polyadenylation | 11287430|11463842 |
Tgene | ABCA12 | GO:0006869 | lipid transport | 16007253 |
Tgene | ABCA12 | GO:0010875 | positive regulation of cholesterol efflux | 23931754 |
Tgene | ABCA12 | GO:0072659 | protein localization to plasma membrane | 23931754 |
Fusion gene breakpoints across PAPOLG (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across ABCA12 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | PRAD | TCGA-EJ-7784-01A | PAPOLG | chr2 | 60997646 | - | ABCA12 | chr2 | 215821502 | - |
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Fusion Gene ORF analysis for PAPOLG-ABCA12 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000238714 | ENST00000272895 | PAPOLG | chr2 | 60997646 | - | ABCA12 | chr2 | 215821502 | - |
In-frame | ENST00000238714 | ENST00000389661 | PAPOLG | chr2 | 60997646 | - | ABCA12 | chr2 | 215821502 | - |
5CDS-intron | ENST00000238714 | ENST00000412081 | PAPOLG | chr2 | 60997646 | - | ABCA12 | chr2 | 215821502 | - |
intron-3CDS | ENST00000483370 | ENST00000272895 | PAPOLG | chr2 | 60997646 | - | ABCA12 | chr2 | 215821502 | - |
intron-3CDS | ENST00000483370 | ENST00000389661 | PAPOLG | chr2 | 60997646 | - | ABCA12 | chr2 | 215821502 | - |
intron-intron | ENST00000483370 | ENST00000412081 | PAPOLG | chr2 | 60997646 | - | ABCA12 | chr2 | 215821502 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000238714 | PAPOLG | chr2 | 60997646 | - | ENST00000272895 | ABCA12 | chr2 | 215821502 | - | 3504 | 741 | 225 | 2411 | 728 |
ENST00000238714 | PAPOLG | chr2 | 60997646 | - | ENST00000389661 | ABCA12 | chr2 | 215821502 | - | 2424 | 741 | 225 | 2411 | 728 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000238714 | ENST00000272895 | PAPOLG | chr2 | 60997646 | - | ABCA12 | chr2 | 215821502 | - | 0.000965885 | 0.99903417 |
ENST00000238714 | ENST00000389661 | PAPOLG | chr2 | 60997646 | - | ABCA12 | chr2 | 215821502 | - | 0.001573684 | 0.9984263 |
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Fusion Genomic Features for PAPOLG-ABCA12 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PAPOLG-ABCA12 |
Go to FGviewer for the breakpoints of chr2:60997646-chr2:215821502 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | ABCA12 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Probable transporter involved in lipid homeostasis. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PAPOLG | chr2:60997646 | chr2:215821502 | ENST00000238714 | - | 6 | 22 | 112_114 | 164.0 | 737.0 | Nucleotide binding | ATP |
Hgene | PAPOLG | chr2:60997646 | chr2:215821502 | ENST00000238714 | - | 6 | 22 | 99_101 | 164.0 | 737.0 | Nucleotide binding | ATP |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 2254_2489 | 2039.0 | 2596.0 | Domain | ABC transporter 2 | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 2254_2489 | 1721.0 | 2278.0 | Domain | ABC transporter 2 | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 2290_2297 | 2039.0 | 2596.0 | Nucleotide binding | ATP 2 | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 2290_2297 | 1721.0 | 2278.0 | Nucleotide binding | ATP 2 | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 2072_2092 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 2103_2123 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 2187_2207 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 2270_2290 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 1747_1767 | 1721.0 | 2278.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 1979_1999 | 1721.0 | 2278.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 2035_2055 | 1721.0 | 2278.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 2072_2092 | 1721.0 | 2278.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 2103_2123 | 1721.0 | 2278.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 2187_2207 | 1721.0 | 2278.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 2270_2290 | 1721.0 | 2278.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PAPOLG | chr2:60997646 | chr2:215821502 | ENST00000238714 | - | 6 | 22 | 245_246 | 164.0 | 737.0 | Nucleotide binding | ATP |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 1346_1577 | 2039.0 | 2596.0 | Domain | ABC transporter 1 | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 1346_1577 | 1721.0 | 2278.0 | Domain | ABC transporter 1 | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 1378_1385 | 2039.0 | 2596.0 | Nucleotide binding | ATP 1 | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 1378_1385 | 1721.0 | 2278.0 | Nucleotide binding | ATP 1 | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 1065_1085 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 1112_1132 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 1145_1165 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 1174_1194 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 1200_1220 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 1250_1270 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 1747_1767 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 1979_1999 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 2035_2055 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000272895 | 40 | 53 | 23_43 | 2039.0 | 2596.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 1065_1085 | 1721.0 | 2278.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 1112_1132 | 1721.0 | 2278.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 1145_1165 | 1721.0 | 2278.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 1174_1194 | 1721.0 | 2278.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 1200_1220 | 1721.0 | 2278.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 1250_1270 | 1721.0 | 2278.0 | Transmembrane | Helical | |
Tgene | ABCA12 | chr2:60997646 | chr2:215821502 | ENST00000389661 | 32 | 45 | 23_43 | 1721.0 | 2278.0 | Transmembrane | Helical |
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Fusion Gene Sequence for PAPOLG-ABCA12 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000238714_ENST00000272895_TCGA-EJ-7784-01A_PAPOLG_chr2_60997646_-_ABCA12_chr2_215821502_length(transcript)=3504nt_BP=741nt CTGAGACCTGCGAGAGGCAGGCTGGGAAGCGGCGCCATATTGGCGTCGGCCGCGCTGTATTGTCATAAATAGAGCCGGTTTTGTGGTGTT TTCACTACTCGGTTGGATGCCTCAGCCATAGTAAGTGGGAAAGTGAGCGAGCAAGCGAGCTACTAGCGACCGGAGGAAAGTGAACAGGGG GAGAAGGGAACAGCAAGAACAGGACTCCAGAGCGATAAACACTCGCTGGAGAGGGAGACGCAGGAAGCGATGAAAGAGATGTCTGCAAAC ACCGTGCTGGACAGCCAGCGTCAACAAAAGCATTATGGAATTACCTCCCCAATTAGTTTGGCATCTCCTAAAGAAATTGATCATATTTAC ACACAGAAATTAATTGACGCCATGAAACCATTTGGAGTGTTTGAAGATGAGGAAGAATTGAACCACAGGCTGGTGGTTCTTGGTAAATTG AACAATTTAGTAAAAGAATGGATTTCTGATGTCAGCGAGAGTAAGAACCTCCCACCTTCTGTTGTGGCTACTGTTGGTGGTAAAATTTTC ACATTTGGATCCTATAGGCTTGGAGTACACACCAAAGGAGCTGACATTGATGCACTTTGTGTAGCTCCAAGACATGTGGAAAGATCTGAT TTTTTTCAGTCTTTTTTTGAAAAATTGAAACATCAAGATGGCATTAGAAACTTAAGAGCTGTAGAAGATGCCTTTGTACCTGTTATAAAA TTTGAATTTGATGGTATTGAAGTTTTCTACTTGGTGCCTGTAGCGTTTTCAATTGGTATCATTGCGATTTTCAAATTACCTGCATTCTAC AGTGAAAACAACCTAGGCGCTGTATCTCTCCTACTTCTCCTGTTTGGGTATGCAACATTTTCCTGGATGTACTTGCTGGCTGGGCTCTTC CATGAAACAGGAATGGCCTTCATCACTTACGTCTGTGTCAACTTGTTTTTTGGCATTAATTCCATTGTTTCCCTGTCAGTGGTATACTTT CTTTCCAAGGAAAAGCCTAATGATCCGACTTTAGAACTTATTTCTGAAACCCTCAAGCGCATTTTCCTGATTTTCCCACAATTCTGTTTT GGCTACGGTTTGATTGAACTTTCTCAACAACAGTCGGTCCTAGACTTCTTAAAAGCATATGGAGTGGAATACCCAAATGAAACCTTTGAG ATGAATAAACTAGGTGCAATGTTTGTGGCTTTGGTTTCTCAGGGCACCATGTTTTTTTCCTTGCGACTCTTAATCAACGAATCCCTGATA AAGAAACTCAGGCTTTTCTTCAGAAAATTTAATTCTTCACATGTAAGGGAGACAATAGATGAGGATGAAGATGTGCGGGCTGAGAGATTA AGAGTTGAGAGTGGTGCAGCTGAATTTGACTTGGTCCAACTTTATTGTCTCACAAAGACCTACCAACTTATCCACAAAAAGATTATAGCT GTAAACAACATCAGCATTGGGATACCTGCTGGAGAGTGTTTTGGGCTTCTTGGAGTGAATGGAGCAGGAAAGACCACTATATTCAAGATG CTGACAGGAGACATCATTCCTTCAAGTGGAAACATTCTGATCAGAAATAAGACCGGATCTCTGGGTCACGTTGATTCTCACAGCTCATTA GTTGGCTACTGTCCTCAGGAAGATGCCTTAGATGACCTGGTAACTGTGGAAGAACATTTGTATTTCTATGCCAGGGTACATGGAATTCCA GAAAAGGATATTAAAGAAACTGTTCATAAACTCCTTAGGAGACTTCACCTGATGCCCTTCAAGGACAGAGCTACCTCTATGTGCAGTTAT GGCACAAAAAGAAAATTATCCACTGCACTGGCCTTGATAGGGAAACCTTCCATTCTACTGCTGGATGAGCCGAGCTCTGGCATGGATCCG AAGTCGAAACGGCACCTCTGGAAGATCATTTCAGAAGAAGTACAGAACAAATGTTCCGTCATCCTCACATCTCACAGCATGGAAGAATGT GAAGCTCTCTGTACCAGGTTGGCCATTATGGTGAATGGAAAGTTTCAATGTATTGGATCTTTGCAGCACATAAAGAGCAGGTTTGGACGA GGATTTACTGTCAAAGTTCACTTGAAGAATAACAAAGTGACCATGGAGACCCTCACAAAGTTCATGCAGCTGCACTTTCCAAAAACATAC TTAAAAGATCAGCACCTCAGCATGCTAGAGTATCATGTACCAGTCACAGCAGGAGGAGTCGCAAACATTTTTGATCTGCTGGAAACCAAC AAGACTGCTTTAAATATTACAAATTTCTTAGTGAGTCAGACCACTCTGGAAGAGGTTTTCATCAACTTTGCCAAAGACCAGAAGTCCTAT GAAACTGCTGATACCAGCAGCCAAGGTTCCACTATAAGTGTTGACTCACAAGATGACCAGATGGAGTCTTAACACTTCCAGCAAACTCAA TCTCAGCGTGTGACCAATGGCTTCATTTTGAAGAAAAGCCACAGAAGATACACTTCCGCAAGATATCTTCATTTTAAAGTAAAGTAATAT ACTGTATGGAAAGTTACAACTGTGTTAGACTAACAAGTAATTATAAAAGGAAATTTTTCCTTCTAAGGTCAGTGAGTGTTGTTGCTACTG AAATGAATTCCTGTATACTCAACACTGTGAGCATGCTAATGTATATGCTGGTGATTCTTATGCAAAGGTGAAGCCACCTCAAGATGAATA TCTTAATTTATTACTTTCAATAAAAAGACAGTTTAAAAGGCATGGATTTTGGTAGTTGAAATATAAGAGTGGAGAAGAAAAGTCAGATGG TTTGTGGCAGGTGCCACCGGGCAAGCAGACAACATAATTTATTTCCAGAAAACAACAGAATGAACATCATCATGAATACATGAATCGGCT GTGATGTGTGAACTGCTAAGGGCCAAATGAACGTTTGCAGAGCAGTGGGCACAATGTTTACAATGTATGTGTATGTCACTTTCGGTACCT GTGAATGCATGGGGACGTGCTGAACCCGAAAAAAAGTGCCTTTCCATAAGGACTGCAATAGAGAGGGCAATTTACCCTGGTGGTACACGG AACCTAGATTCACTCCTGCCATGCCTTGCCAATAGTAAGCTGCAGGGTGGAACAAGAAATCACTTGCTCTGGGGGGAAGGGAGGGGGGAA TGGGTGTGTCAGCTGGGTAGATACAAACCCTGAAAAGAGAATCCATGTGCTACTGGCAGGCAACATTTTTTAAAGCTCTTTCAGAAACCC TCATATTTGGGGTTTCTTTTCAGGAAACATTCCTGTGGAGGGAAAACGAATATGAAGATAATTTTCAGCTAATTATCTGGGTGACCCAGA ATCGTGTATATGGCTATAGGATAGACTTCTTAATAATGGCAAGTGACGTGGCCCTGGGGAAAGGTGCTTTATGTACCGTGTGTGCGTGTA >In-frame_ENST00000238714_ENST00000272895_TCGA-EJ-7784-01A_PAPOLG_chr2_60997646_-_ABCA12_chr2_215821502_length(amino acids)=728AA_start in transcript=225_stop in transcript=2411 MERETQEAMKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHRLVVLGKLNNLVKEWISDVSESK NLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEVFYLVPVA FSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELIS ETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHV RETIDEDEDVRAERLRVESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIR NKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGK PSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTM ETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQGSTISVD -------------------------------------------------------------- >In-frame_ENST00000238714_ENST00000389661_TCGA-EJ-7784-01A_PAPOLG_chr2_60997646_-_ABCA12_chr2_215821502_length(transcript)=2424nt_BP=741nt CTGAGACCTGCGAGAGGCAGGCTGGGAAGCGGCGCCATATTGGCGTCGGCCGCGCTGTATTGTCATAAATAGAGCCGGTTTTGTGGTGTT TTCACTACTCGGTTGGATGCCTCAGCCATAGTAAGTGGGAAAGTGAGCGAGCAAGCGAGCTACTAGCGACCGGAGGAAAGTGAACAGGGG GAGAAGGGAACAGCAAGAACAGGACTCCAGAGCGATAAACACTCGCTGGAGAGGGAGACGCAGGAAGCGATGAAAGAGATGTCTGCAAAC ACCGTGCTGGACAGCCAGCGTCAACAAAAGCATTATGGAATTACCTCCCCAATTAGTTTGGCATCTCCTAAAGAAATTGATCATATTTAC ACACAGAAATTAATTGACGCCATGAAACCATTTGGAGTGTTTGAAGATGAGGAAGAATTGAACCACAGGCTGGTGGTTCTTGGTAAATTG AACAATTTAGTAAAAGAATGGATTTCTGATGTCAGCGAGAGTAAGAACCTCCCACCTTCTGTTGTGGCTACTGTTGGTGGTAAAATTTTC ACATTTGGATCCTATAGGCTTGGAGTACACACCAAAGGAGCTGACATTGATGCACTTTGTGTAGCTCCAAGACATGTGGAAAGATCTGAT TTTTTTCAGTCTTTTTTTGAAAAATTGAAACATCAAGATGGCATTAGAAACTTAAGAGCTGTAGAAGATGCCTTTGTACCTGTTATAAAA TTTGAATTTGATGGTATTGAAGTTTTCTACTTGGTGCCTGTAGCGTTTTCAATTGGTATCATTGCGATTTTCAAATTACCTGCATTCTAC AGTGAAAACAACCTAGGCGCTGTATCTCTCCTACTTCTCCTGTTTGGGTATGCAACATTTTCCTGGATGTACTTGCTGGCTGGGCTCTTC CATGAAACAGGAATGGCCTTCATCACTTACGTCTGTGTCAACTTGTTTTTTGGCATTAATTCCATTGTTTCCCTGTCAGTGGTATACTTT CTTTCCAAGGAAAAGCCTAATGATCCGACTTTAGAACTTATTTCTGAAACCCTCAAGCGCATTTTCCTGATTTTCCCACAATTCTGTTTT GGCTACGGTTTGATTGAACTTTCTCAACAACAGTCGGTCCTAGACTTCTTAAAAGCATATGGAGTGGAATACCCAAATGAAACCTTTGAG ATGAATAAACTAGGTGCAATGTTTGTGGCTTTGGTTTCTCAGGGCACCATGTTTTTTTCCTTGCGACTCTTAATCAACGAATCCCTGATA AAGAAACTCAGGCTTTTCTTCAGAAAATTTAATTCTTCACATGTAAGGGAGACAATAGATGAGGATGAAGATGTGCGGGCTGAGAGATTA AGAGTTGAGAGTGGTGCAGCTGAATTTGACTTGGTCCAACTTTATTGTCTCACAAAGACCTACCAACTTATCCACAAAAAGATTATAGCT GTAAACAACATCAGCATTGGGATACCTGCTGGAGAGTGTTTTGGGCTTCTTGGAGTGAATGGAGCAGGAAAGACCACTATATTCAAGATG CTGACAGGAGACATCATTCCTTCAAGTGGAAACATTCTGATCAGAAATAAGACCGGATCTCTGGGTCACGTTGATTCTCACAGCTCATTA GTTGGCTACTGTCCTCAGGAAGATGCCTTAGATGACCTGGTAACTGTGGAAGAACATTTGTATTTCTATGCCAGGGTACATGGAATTCCA GAAAAGGATATTAAAGAAACTGTTCATAAACTCCTTAGGAGACTTCACCTGATGCCCTTCAAGGACAGAGCTACCTCTATGTGCAGTTAT GGCACAAAAAGAAAATTATCCACTGCACTGGCCTTGATAGGGAAACCTTCCATTCTACTGCTGGATGAGCCGAGCTCTGGCATGGATCCG AAGTCGAAACGGCACCTCTGGAAGATCATTTCAGAAGAAGTACAGAACAAATGTTCCGTCATCCTCACATCTCACAGCATGGAAGAATGT GAAGCTCTCTGTACCAGGTTGGCCATTATGGTGAATGGAAAGTTTCAATGTATTGGATCTTTGCAGCACATAAAGAGCAGGTTTGGACGA GGATTTACTGTCAAAGTTCACTTGAAGAATAACAAAGTGACCATGGAGACCCTCACAAAGTTCATGCAGCTGCACTTTCCAAAAACATAC TTAAAAGATCAGCACCTCAGCATGCTAGAGTATCATGTACCAGTCACAGCAGGAGGAGTCGCAAACATTTTTGATCTGCTGGAAACCAAC AAGACTGCTTTAAATATTACAAATTTCTTAGTGAGTCAGACCACTCTGGAAGAGGTTTTCATCAACTTTGCCAAAGACCAGAAGTCCTAT >In-frame_ENST00000238714_ENST00000389661_TCGA-EJ-7784-01A_PAPOLG_chr2_60997646_-_ABCA12_chr2_215821502_length(amino acids)=728AA_start in transcript=225_stop in transcript=2411 MERETQEAMKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHRLVVLGKLNNLVKEWISDVSESK NLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEVFYLVPVA FSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELIS ETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHV RETIDEDEDVRAERLRVESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIR NKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGK PSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTM ETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQGSTISVD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PAPOLG-ABCA12 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PAPOLG-ABCA12 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PAPOLG-ABCA12 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ABCA12 | C0079154 | Congenital Nonbullous Ichthyosiform Erythroderma | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Tgene | ABCA12 | C1832550 | Lamellar ichthyosis, type 2 | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | ABCA12 | C0598226 | Harlequin type ichthyosis | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Tgene | ABCA12 | C0239849 | Harlequin Fetus | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Tgene | ABCA12 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
Tgene | ABCA12 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | ABCA12 | C0020758 | Congenital ichthyosis | 1 | CTD_human |
Tgene | ABCA12 | C3536797 | Ichthyosis Congenita II | 1 | CTD_human |
Tgene | ABCA12 | C3543867 | Collodion Fetus | 1 | CTD_human |
Tgene | ABCA12 | C4551630 | Ichthyosis Congenita I | 1 | CTD_human |