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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PAPSS1-GAB1 (FusionGDB2 ID:62244)

Fusion Gene Summary for PAPSS1-GAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: PAPSS1-GAB1
Fusion gene ID: 62244
HgeneTgene
Gene symbol

PAPSS1

GAB1

Gene ID

9061

128869

Gene name3'-phosphoadenosine 5'-phosphosulfate synthase 1phosphatidylinositol glycan anchor biosynthesis class U
SynonymsATPSK1|PAPSS|SK1CDC91L1|GAB1|GPIBD21
Cytomap

4q25

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionbifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 13-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1PAPS synthase 1PAPSS 1SK 1adenylyl-sulfate kinasesulfate adenylyltransferasesulfurylase kinase 1phosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI transamidase component PIG-UGPI transamidase subunitcell division cycle 91-like 1 proteincell division cycle protein 91-li
Modification date2020031320200322
UniProtAcc.

Q13480

Ensembl transtripts involved in fusion geneENST00000265174, ENST00000511304, 
ENST00000262995, ENST00000262994, 
ENST00000505913, ENST00000515388, 
Fusion gene scores* DoF score7 X 6 X 4=1688 X 7 X 5=280
# samples 79
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAPSS1 [Title/Abstract] AND GAB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPAPSS1(108565957)-GAB1(144336629), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAPSS1

GO:0000103

sulfate assimilation

14747722

HgenePAPSS1

GO:0050428

3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

14747722|23207770

TgeneGAB1

GO:0006506

GPI anchor biosynthetic process

15034568

TgeneGAB1

GO:0046425

regulation of JAK-STAT cascade

15034568


check buttonFusion gene breakpoints across PAPSS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GAB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L7-A56GPAPSS1chr4

108565957

-GAB1chr4

144336629

+
ChimerDB4ESCATCGA-L7-A56GPAPSS1chr4

108565957

-GAB1chr4

144336629

+


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Fusion Gene ORF analysis for PAPSS1-GAB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265174ENST00000262995PAPSS1chr4

108565957

-GAB1chr4

144336629

+
In-frameENST00000265174ENST00000262994PAPSS1chr4

108565957

-GAB1chr4

144336629

+
5CDS-5UTRENST00000265174ENST00000505913PAPSS1chr4

108565957

-GAB1chr4

144336629

+
5CDS-intronENST00000265174ENST00000515388PAPSS1chr4

108565957

-GAB1chr4

144336629

+
intron-3CDSENST00000511304ENST00000262995PAPSS1chr4

108565957

-GAB1chr4

144336629

+
intron-3CDSENST00000511304ENST00000262994PAPSS1chr4

108565957

-GAB1chr4

144336629

+
intron-5UTRENST00000511304ENST00000505913PAPSS1chr4

108565957

-GAB1chr4

144336629

+
intron-intronENST00000511304ENST00000515388PAPSS1chr4

108565957

-GAB1chr4

144336629

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265174PAPSS1chr4108565957-ENST00000262995GAB1chr4144336629+9261177921038811223
ENST00000265174PAPSS1chr4108565957-ENST00000262994GAB1chr4144336629+4053177921037911193

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265174ENST00000262995PAPSS1chr4108565957-GAB1chr4144336629+7.75E-050.9999224
ENST00000265174ENST00000262994PAPSS1chr4108565957-GAB1chr4144336629+0.0007884260.99921155

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Fusion Genomic Features for PAPSS1-GAB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PAPSS1chr4108565957-GAB1chr4144336629+9.01E-060.99999094
PAPSS1chr4108565957-GAB1chr4144336629+9.01E-060.99999094

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PAPSS1-GAB1


check button Go to

FGviewer for the breakpoints of chr4:108565957-chr4:144336629

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GAB1

Q13480

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPSS1chr4:108565957chr4:144336629ENST00000265174-1012419_422502.0625.0Nucleotide bindingATP 2
HgenePAPSS1chr4:108565957chr4:144336629ENST00000265174-101262_67502.0625.0Nucleotide bindingATP 1
HgenePAPSS1chr4:108565957chr4:144336629ENST00000265174-1012106_109502.0625.0RegionAdenylyl sulfate binding
HgenePAPSS1chr4:108565957chr4:144336629ENST00000265174-1012132_133502.0625.0RegionAdenylyl sulfate binding
HgenePAPSS1chr4:108565957chr4:144336629ENST00000265174-1012184_185502.0625.0RegionAdenylyl sulfate binding
HgenePAPSS1chr4:108565957chr4:144336629ENST00000265174-10121_225502.0625.0RegionAdenylyl-sulfate kinase
HgenePAPSS1chr4:108565957chr4:144336629ENST00000265174-101289_92502.0625.0RegionAdenylyl sulfate binding
TgeneGAB1chr4:108565957chr4:144336629ENST00000262994010449_54024.0695.0Compositional biasNote=Pro-rich
TgeneGAB1chr4:108565957chr4:144336629ENST00000262995011449_54024.0725.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPSS1chr4:108565957chr4:144336629ENST00000265174-1012521_525502.0625.0Nucleotide bindingATP 2
HgenePAPSS1chr4:108565957chr4:144336629ENST00000265174-1012234_624502.0625.0RegionSulfate adenylyltransferase
TgeneGAB1chr4:108565957chr4:144336629ENST000002629940105_11624.0695.0DomainPH
TgeneGAB1chr4:108565957chr4:144336629ENST000002629950115_11624.0725.0DomainPH


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Fusion Gene Sequence for PAPSS1-GAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000265174_ENST00000262995_TCGA-L7-A56G_PAPSS1_chr4_108565957_-_GAB1_chr4_144336629_length(transcript)=9261nt_BP=1779nt
GCGAGCGCTGAAGCTCCGCCCCCAGCTTCTACCTCCGGTTCTATCCCGGCGTTTCGCCCTTCCCCACAGACCTCTGCCCCGGACCCATTT
CCGAGGCGCGCCGCATGCGCCGCGCAACCCAGGCCACGAGCACGGGCGCGTGCTTAAGTCAGCGCGCGCCCGCTCCGACGCGAGGAGGCC
CCGCCCTCCAGCCCCGCCCCGCTCGCTGGCCTGCCCTCCTCTTGCTACCCTCCCGGCGCAGAGAACCCCGGCTGCTCAGCGCGCTCCGCG
GTCATGGAGATCCCCGGGAGCCTGTGCAAGAAAGTCAAACTGAGCAATAACGCGCAGAACTGGGGAATGCAGAGAGCAACCAATGTCACC
TACCAAGCCCATCATGTCAGCAGGAACAAGAGAGGTCAGGTGGTGGGGACCAGAGGTGGCTTTCGTGGTTGCACAGTTTGGCTAACAGGC
TTGTCTGGAGCGGGAAAGACTACTGTGAGCATGGCCTTGGAGGAGTACCTGGTTTGTCATGGTATTCCATGCTACACTCTGGATGGTGAC
AATATTCGTCAAGGTCTCAATAAAAATCTTGGCTTTAGTCCTGAAGACAGAGAAGAGAATGTTCGACGCATCGCAGAAGTTGCTAAACTG
TTTGCAGATGCTGGCTTAGTGTGCATCACAAGTTTCATATCACCTTACACTCAGGATCGCAACAATGCAAGGCAAATTCATGAAGGTGCA
AGTTTACCGTTTTTTGAAGTATTTGTTGATGCTCCTCTGCATGTTTGTGAACAGAGGGATGTCAAAGGACTCTACAAAAAAGCCCGGGCA
GGAGAAATTAAAGGTTTCACTGGGATCGATTCTGAATATGAAAAGCCAGAGGCCCCTGAGTTGGTGCTGAAAACAGACTCCTGTGATGTA
AATGACTGTGTCCAGCAAGTTGTGGAACTTCTACAGGAACGGGATATTGTACCTGTGGATGCATCTTATGAAGTAAAAGAACTATATGTG
CCAGAAAATAAACTTCATTTGGCAAAAACAGATGCGGAAACATTACCAGCACTGAAAATTAATAAAGTGGATATGCAGTGGGTGCAGGTT
TTGGCAGAAGGTTGGGCAACCCCATTGAATGGCTTTATGAGAGAGAGGGAGTACTTGCAGTGCCTTCATTTTGATTGTCTTCTGGATGGA
GGTGTCATTAACTTGTCAGTACCTATAGTTCTGACTGCGACTCATGAAGATAAAGAGAGGCTGGACGGCTGTACAGCATTTGCTCTGATG
TATGAGGGCCGCCGTGTGGCCATTCTTCGCAATCCAGAGTTTTTTGAGCACAGGAAAGAGGAGCGCTGTGCCAGACAGTGGGGAACGACA
TGCAAGAACCACCCCTATATTAAGATGGTGATGGAACAAGGAGATTGGCTGATTGGAGGAGATCTTCAAGTCTTGGATCGAGTTTATTGG
AATGATGGTCTTGATCAGTATCGTCTTACTCCTACTGAGCTAAAGCAGAAATTTAAAGATATGAATGCTGATGCTGTCTTTGCATTTCAA
CTACGCAACCCAGTGCACAATGGACATGCCCTGTTAATGCAGGATACCCATAAGCAACTTCTAGAGAGGGGCTACCGGCGCCCTGTCCTC
CTCCTCCACCCTCTGGGTGGCTGGACAAAGGATGACGATGTTCCTTTGATGTGGCGTATGAAGCAGCATGCTGCAGTGTTGGAGGAAGGA
GTTCTGAATCCTGAGACGACAGTGGTGGCCATCTTCCCATCTCCCATGATGTATGCTGGACCAACTGAGGCATGGAAGAGGAGATGGTTC
GTGTTACGCAGTGGCCGTTTAACTGGAGATCCAGATGTTTTGGAATATTACAAAAATGATCATGCCAAGAAGCCTATTCGTATTATTGAT
TTAAATTTATGTCAACAAGTAGATGCTGGATTGACATTTAACAAAAAAGAGTTTGAAAACAGCTACATTTTTGATATCAACACTATTGAC
CGGATTTTCTACTTGGTAGCAGACAGCGAGGAGGAGATGAATAAGTGGGTTCGTTGTATTTGTGACATCTGTGGGTTTAATCCAACAGAA
GAAGATCCTGTGAAGCCACCTGGCAGCTCTTTACAAGCACCAGCTGATTTACCTTTAGCTATAAATACAGCACCACCATCCACCCAGGCA
GATTCATCCTCTGCTACTCTACCTCCTCCATATCAGCTAATCAATGTTCCACCACACCTGGAAACTCTTGGCATTCAGGAGGATCCTCAA
GACTACCTGTTGCTCATCAACTGTCAAAGCAAGAAGCCCGAACCCACCAGAACGCATGCTGATTCTGCAAAATCCACCTCTTCTGAAACA
GACTGCAATGATAACGTCCCTTCTCATAAAAATCCTGCTTCCTCCCAGAGCAAACATGGAATGAATGGCTTTTTTCAGCAGCAAATGATA
TACGACTCTCCACCTTCACGTGCCCCATCTGCTTCAGTTGACTCCAGCCTTTATAACCTGCCCAGGAGTTATTCCCATGATGTTTTACCA
AAGGTGTCTCCATCAAGTACTGAAGCAGATGGAGAACTCTATGTTTTTAATACCCCATCTGGGACATCGAGTGTAGAGACTCAAATGAGG
CATGTATCTATTAGTTATGACATTCCTCCAACACCTGGTAATACTTATCAGATTCCACGAACATTTCCAGAAGGAACCTTGGGACAGACA
TCAAAGCTAGACACTATTCCAGATATTCCTCCACCTCGGCCACCGAAACCACATCCAGCTCATGACCGATCTCCTGTGGAAACGTGTAGT
ATCCCACGCACCGCCTCAGACACTGACAGTAGTTACTGTATCCCTACAGCAGGGATGTCGCCTTCACGTAGTAATACCATTTCCACTGTG
GATTTAAACAAATTGCGAAAAGATGCTAGTTCTCAAGACTGCTATGATATTCCACGAGCATTTCCAAGTGATAGATCTAGTTCACTTGAA
GGCTTCCATAACCACTTTAAAGTCAAAAATGTGTTGACAGTGGGAAGTGTTTCAAGTGAAGAACTGGATGAAAATTACGTCCCAATGAAT
CCCAATTCACCACCACGACAACATTCCAGCAGTTTTACAGAACCAATTCAGGAAGCAAATTATGTGCCAATGACTCCAGGAACATTTGAT
TTTTCCTCATTTGGAATGCAAGTTCCTCCTCCTGCTCATATGGGCTTCAGGTCCAGCCCAAAAACCCCTCCCAGAAGGCCAGTTCCTGTT
GCAGACTGTGAACCACCCCCCGTGGATAGGAACCTCAAGCCAGACAGAAAAGGTCAAAGTCCTAAAATTTTAAGACTCAAACCCCATGGT
TTAGAGCGAACTGATTCACAAACCATAGGTGACTTTGCTACAAGAAGAAAGGTCAAGCCAGCGCCTTTAGAAATAAAACCTTTGCCAGAA
TGGGAAGAATTACAAGCCCCAGTTAGATCTCCCATCACTAGGAGTTTTGCTCGAGACTCTTCCAGGTTTCCCATGTCCCCCCGACCAGAT
TCAGTGCATAGCACAACTTCAAGCAGTGACTCACACGACAGTGAAGAGAATTATGTTCCCATGAACCCAAACCTGTCCAGTGAAGACCCA
AATCTCTTTGGCAGTAACAGTCTTGATGGAGGAAGCAGCCCTATGATCAAGCCCAAAGGAGACAAACAGGTGGAATACTTAGATCTCGAC
TTAGATTCTGGGAAATCCACACCACCACGTAAGCAAAAGAGCAGTGGCTCAGGCAGCAGTGTAGCAGATGAGAGAGTGGATTATGTTGTT
GTTGACCAACAGAAGACCTTGGCTCTAAAGAGTACCCGGGAAGCCTGGACAGATGGGAGACAGTCCACAGAATCAGAAACGCCAGCGAAG
AGTGTGAAATGAAAATATTGCCTTGCCATTTCTGAACAAAAGAAAACTGAATTGTAAAGATAAATCCCTTTTGAAGAATGACTTGACACT
TCCACTCTAGGTAGATCCTCAAATGAGTAGAGTTGAAGTCAAAGGACCTTTCTGACATAATCAAGCAATTTAGACTTAAGTGGTGCTTTG
TGGTATCTGAACAATTCATAACATGTAAATAATGTGGGAAAATAGTATTGTTTAGCTCCCAGAGAAACATTTGTTCCACAGTTAACACAC
TCGTAGTATTACTGTATTTATGCACTTTTTCATCTAAAACATTGTTCTGGGTTTTCCCAATGTACCTTACCATAATTCCTTTGGGAGTTC
TTGTTTTTTGTCACACTACTTTATATAACAATACTAAGTCAACTAAGCTACTTTTAGATTTGGAAATTGCTGTTTACAGTCTAACAACAT
TAAAATGAGAGGTAGATTCACAAGTTAGCTTTCTACCTGAAGCTTCAGGTGATAACCATTAGCTTATACTTGGACTCATCATTTGTTGCC
TTCCAAAATGCTGAGGATAATGTATGTACTGGTGTCAGGACCTAGTTCTCTGGTTAATGTACATTTAGTTTTTAATGGTGGAACTTTGTT
ATATTTTGTTAATTACAGTGTTTTTGGTTCATTGAGTGAAGATTCTGCCGGGTGGGATCTTGCACCTTTGAAAGACTGAATAATTACACT
ACCAAGTAAGCCTGCAAATCATTGATGGCATGCAGTGATGATGTGCTCTTACACTTGTTAACATGTATTAAGTGTTATTTGCAAAAGGTA
GATTATGTAACCAATCAGGTACGTACCAGGCAGTGATGTGCTAATACACTGATCAGGTTTAGACAATGAGCTTTGGTTGTGTTCTTGTTA
GTCCTAATATTGGTTTTCAGTTTGGAATTAATAAAGCAGTTGACATTCACTGTTAGTTACAGCAACATACTGTGATTTTTAATTAGATAG
TAATTCAGATTTATTACTCTATGAAATTCTGTCTTTTGACACCATAGTGCCCTTTCTATGATTTTTTTTACTTAATATTCTTCTTGGCCT
TATATTTAATTCCCTATGCAATTAATATTTTATATCTGCATTTTTTTAAAAAAAATAGATGTTATATAAGTGATTCTCGTATGTAGCACC
TGTTGCTTTTCCACTGAAAGAATTACGGATTTTGTACTGTGATTTATATTCACTGCCCCAATTCAAGAAATATTGGAGCCTTGCTACAAT
GTGAAATGTTATAGTCATGGACTCCTTCCAACCAGATTTCTGAAAACACCAGAGGGATGGTATAATTCTGTCTCACCTATAACATGGTCC
TGTGACATAGATATTAAGACCACAAGTTGTAGTGAGGCTACAATTATATTCGTCTGTCTTGGCTTTGCAACATAATTTAGAAAGCACGTA
TAGTTGTTTTTTAACCAAGTTACATACAATCTCATGTACTGATTTGAGACTTATAACAATTTTTGGAGGGGGCATAGAGAAAGGAGTGCC
CACAGTTGAGGCATGACCCCCTCCATTCAGACCTCTAACTGTTGCCTGAGTACACAGATGTGCCCTGATTTCTGGCCCATTGGCCATAGT
ACTGTGCCTAATCAATGTAATAGGTTTATTTTCCCAATCCTCAAACTAAAAATGTTCATAACAAGATGAATTGTAGACTAGTAACATTTG
ATGCTTTTAAATATTTGCTTCTTTTTAAACAAAAACTAAAACCCAGAAGTGAATTTTTAGGTGGATTTTTAAATAAAAAAGATTGATTGA
GTTTGGTGTGCAAGCTGTTTTATAATGAAACAACAAAATGAAATCTAAAATCCTGAAATGTGCCTAAACTATCAAAACACACGATACAGC
TAATGTGTAAAGATGCTAAATTCTGTTACTTGGAGGATGAATATATTTAAGATTTAAAACACAATAATAAATACATGATTAATTCAAAAA
TAAAAATCTTTACAGCTGCCTATCAAGGGTCTAAAGCACTTAATGAATGTTTTTAGTCTAACTTATCATTAACTTTTTACAAGTCACCAT
ATTTGAAGATCTGTAGCACTCTGATTTTCAGAAAATTTTTCATTCTGAATAATTTAAAAATGGTGATGTATTAGAAAGGCAGTTTGCTTT
AGAAAACTAAATCACATTGAACATTGTATTAGAGAATTAAATTAAAAGTTTCTTACAGAGCAGTATTTTCCAAACATTTTTAGCACTAGA
ATCTTTTTAGATGAAATTTTATGTATAACCCCAATACATAAAGCCTGAAAACTCAATTTTATCAATATAAATGTATTTTGGGTTCACATT
TATGCTTATTCATTTTGGCTCATTACTAAGCATAATAAGATTCTGAGTTATTTCTGAATAACACAAATGTGGAGTTATACATAGTTGATG
AAACCAGCAGCCAATTTATAGCTATGCCCTGTTTTATTTGTATACTATCAAGAAAATTTTGATTCACACAAATGTAAGCAAAAATAATAG
GTTTTAAACATACATCTCAGGAAATTCTTTAATTAGAGATAGCTAAAGTTATTCAAGGTCTATACAAAAATAAGTTATCCTGGTAGTGGA
AGTTAATACATAAGCAGTCTCCAGTGTGGTAAAGTAGGGTATGTAACACATCAGAATGTGCGTTTTTATTAGGTTTTAAAATATGCACGT
ATAAAAACTAAATTTGAATCAAACCCTTTTAACTCACCTCCAAGAAGCTAGACTTTGGCCAGGAATGGGCTAAAAACCACTGGTTAACGA
TGTGACAGTTATGATCTTGGAGATTGGAAATCTTTCTTCCACATTAGAGTTCTTTACCTTAATTCCTTATTCTGAAAAATTGTAAGATTT
TATGAAGGTTTGAATACTGAAGCACAGTTCTGCTTTCAAAAATTAAAATTCAAACTTGAAAAAGCTGTTTAACCCATGGAAGATATCATT
TAGTAAGATGTAAAAGATTTTTTAAATCTACACTTCAGTTTATACATCTTTATCATTATCAATACTATATAAGTTACTGTGAGCATTTTA
GAGAATTCCATAAAGGTACTATGAGTGTGTCTGTATGTGTGTGTATATATAGCATTGTATTTAATCATAGACTAAATTTAATTTGATATA
GAAATACTACTTTACTTGTACATTAAGGTCATAATTTCTGCTGGACTCTTTTATATTTAATTAATGGGGATTATAGTCTTCCTTCATAAA
TGCATTTAAACCTGAAATTGAACACCAGTGTTTTTCTTTTTCTACTTATGGGAAGTTGTCTGCTTCCCCCTTTAGAGAAAACAGTATTTT
TATATTTTGTTAAAATATTAACTACTTTATGCCTACACACTATGCTGTAGATACTGATCATAATTCTTGGGTGTTCACAAACACTCCTAG
TGCCTCTTTTTTGGCCCGTTGAAAGTGTTGGTATTACTACTTTCACTACAGAGCCTTTGGCCCTCTAATAATGCTGAGGTGGGCTGATCC
TTCCCATTTCTGTCTTCGGGTCATTCTGGTAGGTCTTCTCCTCCACTGTCAAGTAAGCAATCAGGTCCGTGACAGGGATTGGACATATGA
ACAAATTAAGTGGATACACACAGTGAGAAAGATACATGCATTCTATGGTAACAACTACTGTCAATAACATCTGATGTTACATGCACATTT
ATATATATATAATTTTAAAAACTGAACTATGAGAAGCCATGGTATAAATGAATATTGTGGACATCATGGACTTGATATGATAGAAATCAA
TTGTCAGCTTGAGAAAGTTGTTTTTAATCTGTCTAAATAGTTCATGCATTACTACAGTTAAAAATAGTTTCATTTGTCTTCTATAGACTT
AATTTTATTCCGGTTCAGTATAATCTCTGTTAACAGAGTTTCAGCAAACTGATTGGTCAAGGTATTAACATAGCTTCTACTTCCTTTACT
TAAAAAGATGTGGTTTTATGTAAGTTCTTGATTACTGATGATCATCCCAAATTTTGACAACAAAATCATATGTATAAATTTATTTCTCCC
CTCTTGTTCATCATCTTTTGTAAAGGTCCCATTGTAGATCTTTTCTGCTACCAAATAAAACTTTTCAAACAATTTGGTTTCAAGACCTTA
AATAGACAAGTTGGATACTAAGATTGTGAACTGATAAGGACATATAAATTTATATTTCCAGCCCTTCCTTAGAGTCTTTATCTGCATCAA
AAACCCAATTCTGCCATTAACTGTGCTTCCCAGTCCCACCTCTATATGTCACTCATTTTCTGCAACAAAGATCTCACTAAATCATGTTGA
AACACAAGTCATGATCCTCTCTAAGTAAATAGAAAAAGCTCCCTGGAAAAACTCTGTTGCCACATGCACGTGCCCTGTTACTCCTCCAGC
CAGCCAGTGCTGCCAGCATTTTATTGTGTAAAAGTCCAAATAAATAAGGGCCTGCATGCAACCTTTATCTTCAGAAACTAGGTTTTATAT
GTAAAATGTGACTTGGGAAATGATTCTGTTTATTAACTGGCTGGGATTTTTCATTTCTATGAAAGTTTCAAACATCTCCAGTACTTTATA
AAATCCCAACAATTGCTGTAAGTCAGCACTTTGGTCCACTCAGCCCACCCAGCCCACTTGCAACTCTGACTCTTCACTGAATCATATTTG
GGAAGTTTGGGTAGGGTGAGGCTATCTTCTTCAAGATTATTTTCTCATATGTCTGTCTGTCACCTTGTAAACCATGAGACTCCTGGGTAT
TTGCATGTAACTTCTTTGAGGAAGTTACCACCATCTCTGATATAGACACACTTTTTGAGTTGCAGTTTCTGTTAGAATTTTTTGGAGACT
AACTTGCCAATTCTGTGAATGTTATTGAATATTTAAAAAGCTGGGTCTGTAATGGGAGGCATTTTATTAGCTGTTGTGATTGGGTAACAT
GTCCCCTTAGATTTCCTGATTTAAAATTATACAAAATTACTATTTTTGATAAAATAAAGGAACACCTACAGAAAATTAAGTTTCTAAGAT
GTTTCTATACTTCATTAGAAAAGATTTTATTACTATTACTTATGGTTATTGGTGATTAACACTTAATGCGTCTCCTCTGATTTTGTGTTC
CATGAGGTGCTTGGAACATTTGGAGTGCTCTGTGCGAGGGACATACAGTGATATAGGAAATTTAAAAATTAAAATAATACCCAAAACCCA
CTTTATCAGATATGGTATTGTGATGGTTAATATTATGTGTCAACTTGGTGAGGCTATGGCGCCCATGTGTTTGGTCAAACACTAGCCTAG

>In-frame_ENST00000265174_ENST00000262995_TCGA-L7-A56G_PAPSS1_chr4_108565957_-_GAB1_chr4_144336629_length(amino acids)=1223AA_start in transcript=210_stop in transcript=3881
MPSSCYPPGAENPGCSARSAVMEIPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVS
MALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVD
APLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKELYVPENKLHLAKT
DAETLPALKINKVDMQWVQVLAEGWATPLNGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATHEDKERLDGCTAFALMYEGRRVAILR
NPEFFEHRKEERCARQWGTTCKNHPYIKMVMEQGDWLIGGDLQVLDRVYWNDGLDQYRLTPTELKQKFKDMNADAVFAFQLRNPVHNGHA
LLMQDTHKQLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGVLNPETTVVAIFPSPMMYAGPTEAWKRRWFVLRSGRLTGD
PDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSS
LQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHK
NPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPP
TPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDAS
SQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPP
PAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRS
PITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPR

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>In-frame_ENST00000265174_ENST00000262994_TCGA-L7-A56G_PAPSS1_chr4_108565957_-_GAB1_chr4_144336629_length(transcript)=4053nt_BP=1779nt
GCGAGCGCTGAAGCTCCGCCCCCAGCTTCTACCTCCGGTTCTATCCCGGCGTTTCGCCCTTCCCCACAGACCTCTGCCCCGGACCCATTT
CCGAGGCGCGCCGCATGCGCCGCGCAACCCAGGCCACGAGCACGGGCGCGTGCTTAAGTCAGCGCGCGCCCGCTCCGACGCGAGGAGGCC
CCGCCCTCCAGCCCCGCCCCGCTCGCTGGCCTGCCCTCCTCTTGCTACCCTCCCGGCGCAGAGAACCCCGGCTGCTCAGCGCGCTCCGCG
GTCATGGAGATCCCCGGGAGCCTGTGCAAGAAAGTCAAACTGAGCAATAACGCGCAGAACTGGGGAATGCAGAGAGCAACCAATGTCACC
TACCAAGCCCATCATGTCAGCAGGAACAAGAGAGGTCAGGTGGTGGGGACCAGAGGTGGCTTTCGTGGTTGCACAGTTTGGCTAACAGGC
TTGTCTGGAGCGGGAAAGACTACTGTGAGCATGGCCTTGGAGGAGTACCTGGTTTGTCATGGTATTCCATGCTACACTCTGGATGGTGAC
AATATTCGTCAAGGTCTCAATAAAAATCTTGGCTTTAGTCCTGAAGACAGAGAAGAGAATGTTCGACGCATCGCAGAAGTTGCTAAACTG
TTTGCAGATGCTGGCTTAGTGTGCATCACAAGTTTCATATCACCTTACACTCAGGATCGCAACAATGCAAGGCAAATTCATGAAGGTGCA
AGTTTACCGTTTTTTGAAGTATTTGTTGATGCTCCTCTGCATGTTTGTGAACAGAGGGATGTCAAAGGACTCTACAAAAAAGCCCGGGCA
GGAGAAATTAAAGGTTTCACTGGGATCGATTCTGAATATGAAAAGCCAGAGGCCCCTGAGTTGGTGCTGAAAACAGACTCCTGTGATGTA
AATGACTGTGTCCAGCAAGTTGTGGAACTTCTACAGGAACGGGATATTGTACCTGTGGATGCATCTTATGAAGTAAAAGAACTATATGTG
CCAGAAAATAAACTTCATTTGGCAAAAACAGATGCGGAAACATTACCAGCACTGAAAATTAATAAAGTGGATATGCAGTGGGTGCAGGTT
TTGGCAGAAGGTTGGGCAACCCCATTGAATGGCTTTATGAGAGAGAGGGAGTACTTGCAGTGCCTTCATTTTGATTGTCTTCTGGATGGA
GGTGTCATTAACTTGTCAGTACCTATAGTTCTGACTGCGACTCATGAAGATAAAGAGAGGCTGGACGGCTGTACAGCATTTGCTCTGATG
TATGAGGGCCGCCGTGTGGCCATTCTTCGCAATCCAGAGTTTTTTGAGCACAGGAAAGAGGAGCGCTGTGCCAGACAGTGGGGAACGACA
TGCAAGAACCACCCCTATATTAAGATGGTGATGGAACAAGGAGATTGGCTGATTGGAGGAGATCTTCAAGTCTTGGATCGAGTTTATTGG
AATGATGGTCTTGATCAGTATCGTCTTACTCCTACTGAGCTAAAGCAGAAATTTAAAGATATGAATGCTGATGCTGTCTTTGCATTTCAA
CTACGCAACCCAGTGCACAATGGACATGCCCTGTTAATGCAGGATACCCATAAGCAACTTCTAGAGAGGGGCTACCGGCGCCCTGTCCTC
CTCCTCCACCCTCTGGGTGGCTGGACAAAGGATGACGATGTTCCTTTGATGTGGCGTATGAAGCAGCATGCTGCAGTGTTGGAGGAAGGA
GTTCTGAATCCTGAGACGACAGTGGTGGCCATCTTCCCATCTCCCATGATGTATGCTGGACCAACTGAGGCATGGAAGAGGAGATGGTTC
GTGTTACGCAGTGGCCGTTTAACTGGAGATCCAGATGTTTTGGAATATTACAAAAATGATCATGCCAAGAAGCCTATTCGTATTATTGAT
TTAAATTTATGTCAACAAGTAGATGCTGGATTGACATTTAACAAAAAAGAGTTTGAAAACAGCTACATTTTTGATATCAACACTATTGAC
CGGATTTTCTACTTGGTAGCAGACAGCGAGGAGGAGATGAATAAGTGGGTTCGTTGTATTTGTGACATCTGTGGGTTTAATCCAACAGAA
GAAGATCCTGTGAAGCCACCTGGCAGCTCTTTACAAGCACCAGCTGATTTACCTTTAGCTATAAATACAGCACCACCATCCACCCAGGCA
GATTCATCCTCTGCTACTCTACCTCCTCCATATCAGCTAATCAATGTTCCACCACACCTGGAAACTCTTGGCATTCAGGAGGATCCTCAA
GACTACCTGTTGCTCATCAACTGTCAAAGCAAGAAGCCCGAACCCACCAGAACGCATGCTGATTCTGCAAAATCCACCTCTTCTGAAACA
GACTGCAATGATAACGTCCCTTCTCATAAAAATCCTGCTTCCTCCCAGAGCAAACATGGAATGAATGGCTTTTTTCAGCAGCAAATGATA
TACGACTCTCCACCTTCACGTGCCCCATCTGCTTCAGTTGACTCCAGCCTTTATAACCTGCCCAGGAGTTATTCCCATGATGTTTTACCA
AAGGTGTCTCCATCAAGTACTGAAGCAGATGGAGAACTCTATGTTTTTAATACCCCATCTGGGACATCGAGTGTAGAGACTCAAATGAGG
CATGTATCTATTAGTTATGACATTCCTCCAACACCTGGTAATACTTATCAGATTCCACGAACATTTCCAGAAGGAACCTTGGGACAGACA
TCAAAGCTAGACACTATTCCAGATATTCCTCCACCTCGGCCACCGAAACCACATCCAGCTCATGACCGATCTCCTGTGGAAACGTGTAGT
ATCCCACGCACCGCCTCAGACACTGACAGTAGTTACTGTATCCCTACAGCAGGGATGTCGCCTTCACGTAGTAATACCATTTCCACTGTG
GATTTAAACAAATTGCGAAAAGATGCTAGTTCTCAAGACTGCTATGATATTCCACGAGCATTTCCAAGTGATAGATCTAGTTCACTTGAA
GGCTTCCATAACCACTTTAAAGTCAAAAATGTGTTGACAGTGGGAAGTGTTTCAAGTGAAGAACTGGATGAAAATTACGTCCCAATGAAT
CCCAATTCACCACCACGACAACATTCCAGCAGTTTTACAGAACCAATTCAGGAAGCAAATTATGTGCCAATGACTCCAGGAACATTTGAT
TTTTCCTCATTTGGAATGCAAGTTCCTCCTCCTGCTCATATGGGCTTCAGGTCCAGCCCAAAAACCCCTCCCAGAAGGCCAGTTCCTGTT
GCAGACTGTGAACCACCCCCCGTGGATAGGAACCTCAAGCCAGACAGAAAAGTCAAGCCAGCGCCTTTAGAAATAAAACCTTTGCCAGAA
TGGGAAGAATTACAAGCCCCAGTTAGATCTCCCATCACTAGGAGTTTTGCTCGAGACTCTTCCAGGTTTCCCATGTCCCCCCGACCAGAT
TCAGTGCATAGCACAACTTCAAGCAGTGACTCACACGACAGTGAAGAGAATTATGTTCCCATGAACCCAAACCTGTCCAGTGAAGACCCA
AATCTCTTTGGCAGTAACAGTCTTGATGGAGGAAGCAGCCCTATGATCAAGCCCAAAGGAGACAAACAGGTGGAATACTTAGATCTCGAC
TTAGATTCTGGGAAATCCACACCACCACGTAAGCAAAAGAGCAGTGGCTCAGGCAGCAGTGTAGCAGATGAGAGAGTGGATTATGTTGTT
GTTGACCAACAGAAGACCTTGGCTCTAAAGAGTACCCGGGAAGCCTGGACAGATGGGAGACAGTCCACAGAATCAGAAACGCCAGCGAAG
AGTGTGAAATGAAAATATTGCCTTGCCATTTCTGAACAAAAGAAAACTGAATTGTAAAGATAAATCCCTTTTGAAGAATGACTTGACACT
TCCACTCTAGGTAGATCCTCAAATGAGTAGAGTTGAAGTCAAAGGACCTTTCTGACATAATCAAGCAATTTAGACTTAAGTGGTGCTTTG
TGGTATCTGAACAATTCATAACATGTAAATAATGTGGGAAAATAGTATTGTTTAGCTCCCAGAGAAACATTTGTTCCACAGTTAACACAC

>In-frame_ENST00000265174_ENST00000262994_TCGA-L7-A56G_PAPSS1_chr4_108565957_-_GAB1_chr4_144336629_length(amino acids)=1193AA_start in transcript=210_stop in transcript=3791
MPSSCYPPGAENPGCSARSAVMEIPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVS
MALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVD
APLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKELYVPENKLHLAKT
DAETLPALKINKVDMQWVQVLAEGWATPLNGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATHEDKERLDGCTAFALMYEGRRVAILR
NPEFFEHRKEERCARQWGTTCKNHPYIKMVMEQGDWLIGGDLQVLDRVYWNDGLDQYRLTPTELKQKFKDMNADAVFAFQLRNPVHNGHA
LLMQDTHKQLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGVLNPETTVVAIFPSPMMYAGPTEAWKRRWFVLRSGRLTGD
PDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSS
LQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHK
NPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPP
TPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDAS
SQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPP
PAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSD
SHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALK

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Fusion Gene PPI Analysis for PAPSS1-GAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PAPSS1-GAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PAPSS1-GAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGAB1C0032460Polycystic Ovary Syndrome1CTD_human
TgeneGAB1C1136382Sclerocystic Ovaries1CTD_human
TgeneGAB1C1854275DEAFNESS, AUTOSOMAL RECESSIVE 261CTD_human;UNIPROT