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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PAPSS2-LIPJ (FusionGDB2 ID:62254)

Fusion Gene Summary for PAPSS2-LIPJ

check button Fusion gene summary
Fusion gene informationFusion gene name: PAPSS2-LIPJ
Fusion gene ID: 62254
HgeneTgene
Gene symbol

PAPSS2

LIPJ

Gene ID

9060

142910

Gene name3'-phosphoadenosine 5'-phosphosulfate synthase 2lipase family member J
SynonymsATPSK2|BCYM4|SK2LIPL1|bA425M17.2
Cytomap

10q23.2-q23.31

10q23.31

Type of geneprotein-codingprotein-coding
Descriptionbifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 23-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2ATP sulfurylase/APS kinase 2ATP sulfurylase/adenosine 5'-phosphosulfate kinasePAPS synthase 2PAPS synthetase 2SK 2adenosine 5'-phlipase member Jlipase Jlipase-like abhydrolase domain-containing protein 1lipase-like, ab-hydrolase domain containing 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361175, ENST00000456849, 
ENST00000427144, ENST00000482258, 
ENST00000371939, 
Fusion gene scores* DoF score8 X 7 X 10=5605 X 5 X 5=125
# samples 1410
** MAII scorelog2(14/560*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/125*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAPSS2 [Title/Abstract] AND LIPJ [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPAPSS2(89419765)-LIPJ(90347022), # samples:2
PAPSS2(89419765)-LIPJ(90347023), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PAPSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LIPJ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A1AIPAPSS2chr10

89419765

+LIPJchr10

90347022

+
ChimerDB4BRCATCGA-AR-A1AIPAPSS2chr10

89419765

+LIPJchr10

90362332

+
ChimerDB4BRCATCGA-AR-A1AIPAPSS2chr10

89419765

+LIPJchr10

90347022

+
ChimerDB4BRCATCGA-AR-A1AI-01APAPSS2chr10

89419765

+LIPJchr10

90362333

+
ChimerDB4BRCATCGA-AR-A1AI-01APAPSS2chr10

89419765

+LIPJchr10

90347023

+
ChimerDB4CESCTCGA-IR-A3LB-01APAPSS2chr10

89419765

+LIPJchr10

90347023

+


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Fusion Gene ORF analysis for PAPSS2-LIPJ

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361175ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90347022

+
5CDS-5UTRENST00000456849ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90347022

+
intron-5UTRENST00000427144ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90347022

+
intron-5UTRENST00000482258ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90347022

+
In-frameENST00000361175ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90362332

+
In-frameENST00000456849ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90362332

+
intron-3CDSENST00000427144ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90362332

+
intron-3CDSENST00000482258ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90362332

+
In-frameENST00000361175ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90362333

+
In-frameENST00000456849ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90362333

+
intron-3CDSENST00000427144ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90362333

+
intron-3CDSENST00000482258ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90362333

+
5CDS-5UTRENST00000361175ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90347023

+
5CDS-5UTRENST00000456849ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90347023

+
intron-5UTRENST00000427144ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90347023

+
intron-5UTRENST00000482258ENST00000371939PAPSS2chr10

89419765

+LIPJchr10

90347023

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361175PAPSS2chr1089419765+ENST00000371939LIPJchr1090362332+843396270773167
ENST00000456849PAPSS2chr1089419765+ENST00000371939LIPJchr1090362332+737290164667167
ENST00000361175PAPSS2chr1089419765+ENST00000371939LIPJchr1090362333+843396270773167
ENST00000456849PAPSS2chr1089419765+ENST00000371939LIPJchr1090362333+737290164667167

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361175ENST00000371939PAPSS2chr1089419765+LIPJchr1090362332+0.0073521920.9926479
ENST00000456849ENST00000371939PAPSS2chr1089419765+LIPJchr1090362332+0.0035362740.9964637
ENST00000361175ENST00000371939PAPSS2chr1089419765+LIPJchr1090362333+0.0073521920.9926479
ENST00000456849ENST00000371939PAPSS2chr1089419765+LIPJchr1090362333+0.0035362740.9964637

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Fusion Genomic Features for PAPSS2-LIPJ


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PAPSS2chr1089419765+LIPJchr1090347022+1.08E-081
PAPSS2chr1089419765+LIPJchr1090362332+1.04E-081
PAPSS2chr1089419765+LIPJchr1090362332+1.04E-081
PAPSS2chr1089419765+LIPJchr1090347022+1.08E-081
PAPSS2chr1089419765+LIPJchr1090347022+1.08E-081
PAPSS2chr1089419765+LIPJchr1090362332+1.04E-081
PAPSS2chr1089419765+LIPJchr1090362332+1.04E-081
PAPSS2chr1089419765+LIPJchr1090347022+1.08E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PAPSS2-LIPJ


check button Go to

FGviewer for the breakpoints of chr10:89419765-chr10:90362332

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPSS2chr10:89419765chr10:90362332ENST00000361175+112409_4129.0615.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89419765chr10:90362332ENST00000361175+112511_5159.0615.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89419765chr10:90362332ENST00000361175+11252_579.0615.0Nucleotide bindingATP 1
HgenePAPSS2chr10:89419765chr10:90362332ENST00000456849+113409_4129.0620.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89419765chr10:90362332ENST00000456849+113511_5159.0620.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89419765chr10:90362332ENST00000456849+11352_579.0620.0Nucleotide bindingATP 1
HgenePAPSS2chr10:89419765chr10:90362333ENST00000361175+112409_4129.0615.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89419765chr10:90362333ENST00000361175+112511_5159.0615.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89419765chr10:90362333ENST00000361175+11252_579.0615.0Nucleotide bindingATP 1
HgenePAPSS2chr10:89419765chr10:90362333ENST00000456849+113409_4129.0620.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89419765chr10:90362333ENST00000456849+113511_5159.0620.0Nucleotide bindingATP 2
HgenePAPSS2chr10:89419765chr10:90362333ENST00000456849+11352_579.0620.0Nucleotide bindingATP 1
HgenePAPSS2chr10:89419765chr10:90362332ENST00000361175+112122_1239.0615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362332ENST00000361175+112174_1759.0615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362332ENST00000361175+1121_2159.0615.0RegionAdenylyl-sulfate kinase
HgenePAPSS2chr10:89419765chr10:90362332ENST00000361175+112224_6149.0615.0RegionSulfate adenylyltransferase
HgenePAPSS2chr10:89419765chr10:90362332ENST00000361175+11279_829.0615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362332ENST00000361175+11296_999.0615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362332ENST00000456849+113122_1239.0620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362332ENST00000456849+113174_1759.0620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362332ENST00000456849+1131_2159.0620.0RegionAdenylyl-sulfate kinase
HgenePAPSS2chr10:89419765chr10:90362332ENST00000456849+113224_6149.0620.0RegionSulfate adenylyltransferase
HgenePAPSS2chr10:89419765chr10:90362332ENST00000456849+11379_829.0620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362332ENST00000456849+11396_999.0620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362333ENST00000361175+112122_1239.0615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362333ENST00000361175+112174_1759.0615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362333ENST00000361175+1121_2159.0615.0RegionAdenylyl-sulfate kinase
HgenePAPSS2chr10:89419765chr10:90362333ENST00000361175+112224_6149.0615.0RegionSulfate adenylyltransferase
HgenePAPSS2chr10:89419765chr10:90362333ENST00000361175+11279_829.0615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362333ENST00000361175+11296_999.0615.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362333ENST00000456849+113122_1239.0620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362333ENST00000456849+113174_1759.0620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362333ENST00000456849+1131_2159.0620.0RegionAdenylyl-sulfate kinase
HgenePAPSS2chr10:89419765chr10:90362333ENST00000456849+113224_6149.0620.0RegionSulfate adenylyltransferase
HgenePAPSS2chr10:89419765chr10:90362333ENST00000456849+11379_829.0620.0RegionAdenylyl sulfate binding
HgenePAPSS2chr10:89419765chr10:90362333ENST00000456849+11396_999.0620.0RegionAdenylyl sulfate binding


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Fusion Gene Sequence for PAPSS2-LIPJ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000361175_ENST00000371939_TCGA-AR-A1AI_PAPSS2_chr10_89419765_+_LIPJ_chr10_90362332_length(transcript)=843nt_BP=396nt
GGCCGCGTGCCGGGCGTGCCATCTGCCGCTCCGCTGCAAGGTCTCGCCCGGGACCGGGGCTGGCGGAGCGCGCGCCCGCGAGTAGGGGCC
GGGCCGGGGACCCCGCCTAGGCGGCGGCGGCCGGGTCCCCAAGGCTGGGCGCTGCTTGCGGAACCGACGGGGCGGAGAGGAGCGTGGCGG
GAGGAGGAGTAGGAGAAGGGGGCTGGTCAAGGGAAGTGCGACGTGTCTGCGGAGCCTTTTTATACCTCCTTCCCGGGAGTCCGGCAGCCG
CTGCTGCTGCTGCTGCTGCTGCTGCCGCCGCCGCCGCCGCCGTCCCTGCGTCCTTCGGTCTCTGCTCCCGGGACCCGGGCTCCGCCGCAG
CCAGCCAGCATGTCGGGGATCAAGAAGCAAAAGACGAGTCGTTTGGATGTGTATTTTTCACACAACCCAGCAGGAACATCTGTTCAAAAT
ATGCTTCATTGGAGTCAGCTTTTAAATTCTACTCATTTGAAAGCTTATGACTGGGGCAGTCCTGATCTGAACTTGGTTCATTATAATCAG
ACAACGTCTCCATTATACAACATGACAAACATGAATGTGGCAACTGCAATTTGGAATGGTAAAAGTGACTTGTTGGCTGACCCTGAAGAC
GTTAACATTTTACATTCTGAAATCACAAACCACATTTATTATAAAACTATTTCTTACTACAATCATATAGACTCTTTGTTTGGATTAGAT
GTCTATGATCAAGTTTACCATGAAATCATTGATATTATCCAAGACAATCTATAAAGAACCATGGCGCTGTGTGTTTAAAGATCTACATCA

>In-frame_ENST00000361175_ENST00000371939_TCGA-AR-A1AI_PAPSS2_chr10_89419765_+_LIPJ_chr10_90362332_length(amino acids)=167AA_start in transcript=270_stop in transcript=773
MLLLLLLLPPPPPPSLRPSVSAPGTRAPPQPASMSGIKKQKTSRLDVYFSHNPAGTSVQNMLHWSQLLNSTHLKAYDWGSPDLNLVHYNQ

--------------------------------------------------------------
>In-frame_ENST00000456849_ENST00000371939_TCGA-AR-A1AI_PAPSS2_chr10_89419765_+_LIPJ_chr10_90362332_length(transcript)=737nt_BP=290nt
CTAGGCGGCGGCGGCCGGGTCCCCAAGGCTGGGCGCTGCTTGCGGAACCGACGGGGCGGAGAGGAGCGTGGCGGGAGGAGGAGTAGGAGA
AGGGGGCTGGTCAAGGGAAGTGCGACGTGTCTGCGGAGCCTTTTTATACCTCCTTCCCGGGAGTCCGGCAGCCGCTGCTGCTGCTGCTGC
TGCTGCTGCCGCCGCCGCCGCCGCCGTCCCTGCGTCCTTCGGTCTCTGCTCCCGGGACCCGGGCTCCGCCGCAGCCAGCCAGCATGTCGG
GGATCAAGAAGCAAAAGACGAGTCGTTTGGATGTGTATTTTTCACACAACCCAGCAGGAACATCTGTTCAAAATATGCTTCATTGGAGTC
AGCTTTTAAATTCTACTCATTTGAAAGCTTATGACTGGGGCAGTCCTGATCTGAACTTGGTTCATTATAATCAGACAACGTCTCCATTAT
ACAACATGACAAACATGAATGTGGCAACTGCAATTTGGAATGGTAAAAGTGACTTGTTGGCTGACCCTGAAGACGTTAACATTTTACATT
CTGAAATCACAAACCACATTTATTATAAAACTATTTCTTACTACAATCATATAGACTCTTTGTTTGGATTAGATGTCTATGATCAAGTTT
ACCATGAAATCATTGATATTATCCAAGACAATCTATAAAGAACCATGGCGCTGTGTGTTTAAAGATCTACATCATTCCTAATGAAATCCA

>In-frame_ENST00000456849_ENST00000371939_TCGA-AR-A1AI_PAPSS2_chr10_89419765_+_LIPJ_chr10_90362332_length(amino acids)=167AA_start in transcript=164_stop in transcript=667
MLLLLLLLPPPPPPSLRPSVSAPGTRAPPQPASMSGIKKQKTSRLDVYFSHNPAGTSVQNMLHWSQLLNSTHLKAYDWGSPDLNLVHYNQ

--------------------------------------------------------------
>In-frame_ENST00000361175_ENST00000371939_TCGA-AR-A1AI-01A_PAPSS2_chr10_89419765_+_LIPJ_chr10_90362333_length(transcript)=843nt_BP=396nt
GGCCGCGTGCCGGGCGTGCCATCTGCCGCTCCGCTGCAAGGTCTCGCCCGGGACCGGGGCTGGCGGAGCGCGCGCCCGCGAGTAGGGGCC
GGGCCGGGGACCCCGCCTAGGCGGCGGCGGCCGGGTCCCCAAGGCTGGGCGCTGCTTGCGGAACCGACGGGGCGGAGAGGAGCGTGGCGG
GAGGAGGAGTAGGAGAAGGGGGCTGGTCAAGGGAAGTGCGACGTGTCTGCGGAGCCTTTTTATACCTCCTTCCCGGGAGTCCGGCAGCCG
CTGCTGCTGCTGCTGCTGCTGCTGCCGCCGCCGCCGCCGCCGTCCCTGCGTCCTTCGGTCTCTGCTCCCGGGACCCGGGCTCCGCCGCAG
CCAGCCAGCATGTCGGGGATCAAGAAGCAAAAGACGAGTCGTTTGGATGTGTATTTTTCACACAACCCAGCAGGAACATCTGTTCAAAAT
ATGCTTCATTGGAGTCAGCTTTTAAATTCTACTCATTTGAAAGCTTATGACTGGGGCAGTCCTGATCTGAACTTGGTTCATTATAATCAG
ACAACGTCTCCATTATACAACATGACAAACATGAATGTGGCAACTGCAATTTGGAATGGTAAAAGTGACTTGTTGGCTGACCCTGAAGAC
GTTAACATTTTACATTCTGAAATCACAAACCACATTTATTATAAAACTATTTCTTACTACAATCATATAGACTCTTTGTTTGGATTAGAT
GTCTATGATCAAGTTTACCATGAAATCATTGATATTATCCAAGACAATCTATAAAGAACCATGGCGCTGTGTGTTTAAAGATCTACATCA

>In-frame_ENST00000361175_ENST00000371939_TCGA-AR-A1AI-01A_PAPSS2_chr10_89419765_+_LIPJ_chr10_90362333_length(amino acids)=167AA_start in transcript=270_stop in transcript=773
MLLLLLLLPPPPPPSLRPSVSAPGTRAPPQPASMSGIKKQKTSRLDVYFSHNPAGTSVQNMLHWSQLLNSTHLKAYDWGSPDLNLVHYNQ

--------------------------------------------------------------
>In-frame_ENST00000456849_ENST00000371939_TCGA-AR-A1AI-01A_PAPSS2_chr10_89419765_+_LIPJ_chr10_90362333_length(transcript)=737nt_BP=290nt
CTAGGCGGCGGCGGCCGGGTCCCCAAGGCTGGGCGCTGCTTGCGGAACCGACGGGGCGGAGAGGAGCGTGGCGGGAGGAGGAGTAGGAGA
AGGGGGCTGGTCAAGGGAAGTGCGACGTGTCTGCGGAGCCTTTTTATACCTCCTTCCCGGGAGTCCGGCAGCCGCTGCTGCTGCTGCTGC
TGCTGCTGCCGCCGCCGCCGCCGCCGTCCCTGCGTCCTTCGGTCTCTGCTCCCGGGACCCGGGCTCCGCCGCAGCCAGCCAGCATGTCGG
GGATCAAGAAGCAAAAGACGAGTCGTTTGGATGTGTATTTTTCACACAACCCAGCAGGAACATCTGTTCAAAATATGCTTCATTGGAGTC
AGCTTTTAAATTCTACTCATTTGAAAGCTTATGACTGGGGCAGTCCTGATCTGAACTTGGTTCATTATAATCAGACAACGTCTCCATTAT
ACAACATGACAAACATGAATGTGGCAACTGCAATTTGGAATGGTAAAAGTGACTTGTTGGCTGACCCTGAAGACGTTAACATTTTACATT
CTGAAATCACAAACCACATTTATTATAAAACTATTTCTTACTACAATCATATAGACTCTTTGTTTGGATTAGATGTCTATGATCAAGTTT
ACCATGAAATCATTGATATTATCCAAGACAATCTATAAAGAACCATGGCGCTGTGTGTTTAAAGATCTACATCATTCCTAATGAAATCCA

>In-frame_ENST00000456849_ENST00000371939_TCGA-AR-A1AI-01A_PAPSS2_chr10_89419765_+_LIPJ_chr10_90362333_length(amino acids)=167AA_start in transcript=164_stop in transcript=667
MLLLLLLLPPPPPPSLRPSVSAPGTRAPPQPASMSGIKKQKTSRLDVYFSHNPAGTSVQNMLHWSQLLNSTHLKAYDWGSPDLNLVHYNQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PAPSS2-LIPJ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PAPSS2-LIPJ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PAPSS2-LIPJ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePAPSS2C2748515Spondyloepimetaphyseal Dysplasia, Pakistani Type6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT