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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PARD3B-WWOX (FusionGDB2 ID:62326)

Fusion Gene Summary for PARD3B-WWOX

check button Fusion gene summary
Fusion gene informationFusion gene name: PARD3B-WWOX
Fusion gene ID: 62326
HgeneTgene
Gene symbol

PARD3B

WWOX

Gene ID

117583

51741

Gene namepar-3 family cell polarity regulator betaWW domain containing oxidoreductase
SynonymsALS2CR19|PAR3B|PAR3L|PAR3betaD16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
Cytomap

2q33.3

16q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptionpartitioning defective 3 homolog BPAR3-L proteinamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 19amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 proteinpar-3 partitioning defective 3 homolog BpartitioningWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000406610, ENST00000462231, 
ENST00000349953, ENST00000358768, 
ENST00000351153, ENST00000488622, 
ENST00000566780, ENST00000406884, 
ENST00000539474, ENST00000402655, 
ENST00000408984, ENST00000355860, 
ENST00000565791, ENST00000569818, 
Fusion gene scores* DoF score18 X 15 X 9=243030 X 23 X 10=6900
# samples 2036
** MAII scorelog2(20/2430*10)=-3.60288440871842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/6900*10)=-4.26052755022322
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PARD3B [Title/Abstract] AND WWOX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPARD3B(205990461)-WWOX(79245505), # samples:3
Anticipated loss of major functional domain due to fusion event.PARD3B-WWOX seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PARD3B-WWOX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

TgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check buttonFusion gene breakpoints across PARD3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across WWOX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-49-6744-01APARD3Bchr2

205990461

+WWOXchr16

79245505

+
ChimerDB4LUADTCGA-49-6744-01APARD3Bchr2

205990461

+WWOXchr16

79245505

+
ChimerDB4LUADTCGA-49-6744-01APARD3Bchr2

205990461

-WWOXchr16

79245505

+


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Fusion Gene ORF analysis for PARD3B-WWOX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000406610ENST00000566780PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000406610ENST00000406884PARD3Bchr2

205990461

+WWOXchr16

79245505

+
In-frameENST00000406610ENST00000539474PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000406610ENST00000402655PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000406610ENST00000408984PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000406610ENST00000355860PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000406610ENST00000565791PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000406610ENST00000569818PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000462231ENST00000566780PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000462231ENST00000406884PARD3Bchr2

205990461

+WWOXchr16

79245505

+
In-frameENST00000462231ENST00000539474PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000462231ENST00000402655PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000462231ENST00000408984PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000462231ENST00000355860PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000462231ENST00000565791PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000462231ENST00000569818PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000349953ENST00000566780PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000349953ENST00000406884PARD3Bchr2

205990461

+WWOXchr16

79245505

+
In-frameENST00000349953ENST00000539474PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000349953ENST00000402655PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000349953ENST00000408984PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000349953ENST00000355860PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000349953ENST00000565791PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000349953ENST00000569818PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000358768ENST00000566780PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000358768ENST00000406884PARD3Bchr2

205990461

+WWOXchr16

79245505

+
In-frameENST00000358768ENST00000539474PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000358768ENST00000402655PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000358768ENST00000408984PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000358768ENST00000355860PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000358768ENST00000565791PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000358768ENST00000569818PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000351153ENST00000566780PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000351153ENST00000406884PARD3Bchr2

205990461

+WWOXchr16

79245505

+
In-frameENST00000351153ENST00000539474PARD3Bchr2

205990461

+WWOXchr16

79245505

+
Frame-shiftENST00000351153ENST00000402655PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000351153ENST00000408984PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000351153ENST00000355860PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000351153ENST00000565791PARD3Bchr2

205990461

+WWOXchr16

79245505

+
5CDS-intronENST00000351153ENST00000569818PARD3Bchr2

205990461

+WWOXchr16

79245505

+
intron-3CDSENST00000488622ENST00000566780PARD3Bchr2

205990461

+WWOXchr16

79245505

+
intron-3CDSENST00000488622ENST00000406884PARD3Bchr2

205990461

+WWOXchr16

79245505

+
intron-3CDSENST00000488622ENST00000539474PARD3Bchr2

205990461

+WWOXchr16

79245505

+
intron-3CDSENST00000488622ENST00000402655PARD3Bchr2

205990461

+WWOXchr16

79245505

+
intron-intronENST00000488622ENST00000408984PARD3Bchr2

205990461

+WWOXchr16

79245505

+
intron-intronENST00000488622ENST00000355860PARD3Bchr2

205990461

+WWOXchr16

79245505

+
intron-intronENST00000488622ENST00000565791PARD3Bchr2

205990461

+WWOXchr16

79245505

+
intron-intronENST00000488622ENST00000569818PARD3Bchr2

205990461

+WWOXchr16

79245505

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000406610PARD3Bchr2205990461+ENST00000539474WWOXchr1679245505+270116411081829573
ENST00000462231PARD3Bchr2205990461+ENST00000539474WWOXchr1679245505+26541594611782573
ENST00000349953PARD3Bchr2205990461+ENST00000539474WWOXchr1679245505+2494143401622540
ENST00000358768PARD3Bchr2205990461+ENST00000539474WWOXchr1679245505+2494143401622540
ENST00000351153PARD3Bchr2205990461+ENST00000539474WWOXchr1679245505+2494143401622540

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000406610ENST00000539474PARD3Bchr2205990461+WWOXchr1679245505+0.001004350.9989956
ENST00000462231ENST00000539474PARD3Bchr2205990461+WWOXchr1679245505+0.0009229920.99907696
ENST00000349953ENST00000539474PARD3Bchr2205990461+WWOXchr1679245505+0.001015390.99898463
ENST00000358768ENST00000539474PARD3Bchr2205990461+WWOXchr1679245505+0.001015390.99898463
ENST00000351153ENST00000539474PARD3Bchr2205990461+WWOXchr1679245505+0.001015390.99898463

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Fusion Genomic Features for PARD3B-WWOX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PARD3Bchr2205990461+WWOXchr1679245504+1.07E-060.9999989
PARD3Bchr2205990461+WWOXchr1679245504+1.07E-060.9999989

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PARD3B-WWOX


check button Go to

FGviewer for the breakpoints of chr2:205990461-chr16:79245505

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARD3Bchr2:205990461chr16:79245505ENST00000349953+1022201_289478.01105.0DomainPDZ 1
HgenePARD3Bchr2:205990461chr16:79245505ENST00000349953+1022383_468478.01105.0DomainPDZ 2
HgenePARD3Bchr2:205990461chr16:79245505ENST00000358768+1022201_289478.01144.0DomainPDZ 1
HgenePARD3Bchr2:205990461chr16:79245505ENST00000358768+1022383_468478.01144.0DomainPDZ 2
HgenePARD3Bchr2:205990461chr16:79245505ENST00000406610+1023201_289478.01206.0DomainPDZ 1
HgenePARD3Bchr2:205990461chr16:79245505ENST00000406610+1023383_468478.01206.0DomainPDZ 2
TgeneWWOXchr2:205990461chr16:79245505ENST000003558600616_490190.0DomainWW 1
TgeneWWOXchr2:205990461chr16:79245505ENST000003558600657_900190.0DomainWW 2
TgeneWWOXchr2:205990461chr16:79245505ENST0000040898401016_490311.6666666666667DomainWW 1
TgeneWWOXchr2:205990461chr16:79245505ENST0000040898401057_900311.6666666666667DomainWW 2
TgeneWWOXchr2:205990461chr16:79245505ENST000005698180116_49037.0DomainWW 1
TgeneWWOXchr2:205990461chr16:79245505ENST000005698180157_90037.0DomainWW 2
TgeneWWOXchr2:205990461chr16:79245505ENST000003558600650_550190.0MotifNuclear localization signal
TgeneWWOXchr2:205990461chr16:79245505ENST0000040898401050_550311.6666666666667MotifNuclear localization signal
TgeneWWOXchr2:205990461chr16:79245505ENST000005698180150_55037.0MotifNuclear localization signal
TgeneWWOXchr2:205990461chr16:79245505ENST0000035586006131_1370190.0Nucleotide bindingNADP
TgeneWWOXchr2:205990461chr16:79245505ENST00000408984010131_1370311.6666666666667Nucleotide bindingNADP
TgeneWWOXchr2:205990461chr16:79245505ENST0000056981801131_137037.0Nucleotide bindingNADP
TgeneWWOXchr2:205990461chr16:79245505ENST0000035586006209_2730190.0RegionMediates targeting to the mitochondria
TgeneWWOXchr2:205990461chr16:79245505ENST0000040265535209_273136.33333333333334312.0RegionMediates targeting to the mitochondria
TgeneWWOXchr2:205990461chr16:79245505ENST0000040688446209_273172.0235.0RegionMediates targeting to the mitochondria
TgeneWWOXchr2:205990461chr16:79245505ENST00000408984010209_2730311.6666666666667RegionMediates targeting to the mitochondria
TgeneWWOXchr2:205990461chr16:79245505ENST0000056981801209_273037.0RegionMediates targeting to the mitochondria

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARD3Bchr2:205990461chr16:79245505ENST00000349953+10221144_1149478.01105.0Compositional biasNote=Poly-Pro
HgenePARD3Bchr2:205990461chr16:79245505ENST00000349953+1022830_896478.01105.0Compositional biasNote=Lys-rich
HgenePARD3Bchr2:205990461chr16:79245505ENST00000358768+10221144_1149478.01144.0Compositional biasNote=Poly-Pro
HgenePARD3Bchr2:205990461chr16:79245505ENST00000358768+1022830_896478.01144.0Compositional biasNote=Lys-rich
HgenePARD3Bchr2:205990461chr16:79245505ENST00000406610+10231144_1149478.01206.0Compositional biasNote=Poly-Pro
HgenePARD3Bchr2:205990461chr16:79245505ENST00000406610+1023830_896478.01206.0Compositional biasNote=Lys-rich
HgenePARD3Bchr2:205990461chr16:79245505ENST00000349953+1022498_585478.01105.0DomainPDZ 3
HgenePARD3Bchr2:205990461chr16:79245505ENST00000358768+1022498_585478.01144.0DomainPDZ 3
HgenePARD3Bchr2:205990461chr16:79245505ENST00000406610+1023498_585478.01206.0DomainPDZ 3
TgeneWWOXchr2:205990461chr16:79245505ENST000004026553516_49136.33333333333334312.0DomainWW 1
TgeneWWOXchr2:205990461chr16:79245505ENST000004026553557_90136.33333333333334312.0DomainWW 2
TgeneWWOXchr2:205990461chr16:79245505ENST000004068844616_49172.0235.0DomainWW 1
TgeneWWOXchr2:205990461chr16:79245505ENST000004068844657_90172.0235.0DomainWW 2
TgeneWWOXchr2:205990461chr16:79245505ENST000005667807916_49352.0415.0DomainWW 1
TgeneWWOXchr2:205990461chr16:79245505ENST000005667807957_90352.0415.0DomainWW 2
TgeneWWOXchr2:205990461chr16:79245505ENST000004026553550_55136.33333333333334312.0MotifNuclear localization signal
TgeneWWOXchr2:205990461chr16:79245505ENST000004068844650_55172.0235.0MotifNuclear localization signal
TgeneWWOXchr2:205990461chr16:79245505ENST000005667807950_55352.0415.0MotifNuclear localization signal
TgeneWWOXchr2:205990461chr16:79245505ENST0000040265535131_137136.33333333333334312.0Nucleotide bindingNADP
TgeneWWOXchr2:205990461chr16:79245505ENST0000040688446131_137172.0235.0Nucleotide bindingNADP
TgeneWWOXchr2:205990461chr16:79245505ENST0000056678079131_137352.0415.0Nucleotide bindingNADP
TgeneWWOXchr2:205990461chr16:79245505ENST0000056678079209_273352.0415.0RegionMediates targeting to the mitochondria


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Fusion Gene Sequence for PARD3B-WWOX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000406610_ENST00000539474_TCGA-49-6744-01A_PARD3B_chr2_205990461_+_WWOX_chr16_79245505_length(transcript)=2701nt_BP=1641nt
GCGGCCGCCCCTCCCCGATTCCCGCCACCTGCCGCCTGGCCAGGTGGAAGGGGCGCTGCCGCGAGCCTCCGGGCCTCAGGGTGTTCCGGG
GAGCGGCGCCCCGGGTCTCTGGGCCCACCCGCCCCGGGCGTCCTCCGAGAGTGGGGGCTGCGCCCGCGGGGTCAGACACCTGTTCGGCCC
GGCCCGGCGTGGTCGCCGGGGGCCAGGATGAAAGTGACCGTGTGCTTCGGCAGGACGGGCATCGTGGTGCCCTGCAAGGAGGGCCAGCTG
CGCGTCGGCGAGCTCACCCAGCAGGCGCTGCAGCGGTACCTGAAGACCCGGGAGAAGGGTCCTGGTTACTGGGTGAAGATTCATCACTTA
GAATATACAGATGGAGGAATCCTGGATCCAGATGATGTCTTGGCAGATGTTGTTGAAGATAAAGACAAGCTGATTGCTGTGTTTGAAGAA
CAAGAACCACTCCACAAGATTGAGAGCCCCAGTGGAAACCCTGCAGATCGGCAGAGCCCAGATGCTTTTGAGACAGAAGTGGCCGCCCAA
CTGGCCGCATTTAAGCCAATTGGTGGGGAGATTGAAGTAACCCCTTCTGCTCTAAAACTAGGCACTCCACTGCTGGTGAGGAGAAGCAGT
GACCCAGTGCCAGGCCCACCTGCTGATACCCAGCCAAGCGCTTCACACCCTGGTGGCCAGAGTCTGAAACTGGTTGTTCCAGATTCCACG
CAGAACTTGGAAGACAGAGAAGTTTTGAATGGTGTACAGACAGAACTACTAACTTCGCCAAGAACTAAGGACACATTGAGTGATATGACA
AGAACAGTGGAGATTTCTGGGGAAGGAGGCCCATTGGGAATACATGTAGTGCCCTTCTTTTCATCTCTGAGTGGAAGGATTCTAGGACTC
TTCATCCGAGGCATTGAAGACAACAGCAGGTCCAAGCGGGAGGGACTATTTCACGAAAATGAATGTATTGTAAAAATCAACAATGTGGAT
CTCGTAGACAAAACCTTTGCTCAGGCTCAAGATGTCTTCCGCCAGGCAATGAAATCTCCAAGTGTGCTCCTCCACGTGCTTCCTCCACAA
AACCGTGAACAGTATGAAAAGTCAGTCATTGGCTCTCTTAACATTTTTGGTAATAATGATGGCGTTTTGAAAACCAAAGTGCCGCCTCCT
GTCCATGGAAAATCGGGACTAAAGACAGCAAATCTCACAGGAACCGATAGTCCTGAAACAGATGCATCAGCTTCCCTGCAACAAAACAAG
AGTCCCCGAGTACCAAGGCTGGGAGGAAAACCATCCTCTCCCTCACTCTCGCCTCTCATGGGATTTGGCAGCAATAAAAATGCAAAGAAA
ATTAAGATTGACCTAAAGAAAGGCCCTGAAGGACTTGGTTTCACTGTGGTTACCAGAGACTCTTCCATACATGGTCCCGGTCCCATTTTT
GTAAAAAACATTTTACCAAAGGGAGCAGCAATAAAAGATGGCCGCCTACAATCAGGGGACAGAATTTTGGAGGTAAATGGGAGAGATGTC
ACCGGACGAACCCAGGAAGAGCTTGTGGCCATGCTCAGGAGCACCAAGCAGGGGGAGACAGCATCGCTGGTCATTGCCCGCCAAGAAGGA
CATTTTCTGCCCCGAGAGTTGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTAC
TTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATC
CAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTG
CCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTA
AGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGG
CCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAA
TAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGC
AAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGG
AGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTA
CTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAG
GCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATC
ACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATAAAAGAACATGCTTGAATATC

>In-frame_ENST00000406610_ENST00000539474_TCGA-49-6744-01A_PARD3B_chr2_205990461_+_WWOX_chr16_79245505_length(amino acids)=573AA_start in transcript=108_stop in transcript=1829
MGPPAPGVLREWGLRPRGQTPVRPGPAWSPGARMKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGG
ILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGP
PADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIE
DNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSG
LKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILP
KGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELQQGAATTVYCAAVPELEGLGGMYFNNCCR

--------------------------------------------------------------
>In-frame_ENST00000462231_ENST00000539474_TCGA-49-6744-01A_PARD3B_chr2_205990461_+_WWOX_chr16_79245505_length(transcript)=2654nt_BP=1594nt
AAGGGGCGCTGCCGCGAGCCTCCGGGCCTCAGGGTGTTCCGGGGAGCGGCGCCCCGGGTCTCTGGGCCCACCCGCCCCGGGCGTCCTCCG
AGAGTGGGGGCTGCGCCCGCGGGGTCAGACACCTGTTCGGCCCGGCCCGGCGTGGTCGCCGGGGGCCAGGATGAAAGTGACCGTGTGCTT
CGGCAGGACGGGCATCGTGGTGCCCTGCAAGGAGGGCCAGCTGCGCGTCGGCGAGCTCACCCAGCAGGCGCTGCAGCGGTACCTGAAGAC
CCGGGAGAAGGGTCCTGGTTACTGGGTGAAGATTCATCACTTAGAATATACAGATGGAGGAATCCTGGATCCAGATGATGTCTTGGCAGA
TGTTGTTGAAGATAAAGACAAGCTGATTGCTGTGTTTGAAGAACAAGAACCACTCCACAAGATTGAGAGCCCCAGTGGAAACCCTGCAGA
TCGGCAGAGCCCAGATGCTTTTGAGACAGAAGTGGCCGCCCAACTGGCCGCATTTAAGCCAATTGGTGGGGAGATTGAAGTAACCCCTTC
TGCTCTAAAACTAGGCACTCCACTGCTGGTGAGGAGAAGCAGTGACCCAGTGCCAGGCCCACCTGCTGATACCCAGCCAAGCGCTTCACA
CCCTGGTGGCCAGAGTCTGAAACTGGTTGTTCCAGATTCCACGCAGAACTTGGAAGACAGAGAAGTTTTGAATGGTGTACAGACAGAACT
ACTAACTTCGCCAAGAACTAAGGACACATTGAGTGATATGACAAGAACAGTGGAGATTTCTGGGGAAGGAGGCCCATTGGGAATACATGT
AGTGCCCTTCTTTTCATCTCTGAGTGGAAGGATTCTAGGACTCTTCATCCGAGGCATTGAAGACAACAGCAGGTCCAAGCGGGAGGGACT
ATTTCACGAAAATGAATGTATTGTAAAAATCAACAATGTGGATCTCGTAGACAAAACCTTTGCTCAGGCTCAAGATGTCTTCCGCCAGGC
AATGAAATCTCCAAGTGTGCTCCTCCACGTGCTTCCTCCACAAAACCGTGAACAGTATGAAAAGTCAGTCATTGGCTCTCTTAACATTTT
TGGTAATAATGATGGCGTTTTGAAAACCAAAGTGCCGCCTCCTGTCCATGGAAAATCGGGACTAAAGACAGCAAATCTCACAGGAACCGA
TAGTCCTGAAACAGATGCATCAGCTTCCCTGCAACAAAACAAGAGTCCCCGAGTACCAAGGCTGGGAGGAAAACCATCCTCTCCCTCACT
CTCGCCTCTCATGGGATTTGGCAGCAATAAAAATGCAAAGAAAATTAAGATTGACCTAAAGAAAGGCCCTGAAGGACTTGGTTTCACTGT
GGTTACCAGAGACTCTTCCATACATGGTCCCGGTCCCATTTTTGTAAAAAACATTTTACCAAAGGGAGCAGCAATAAAAGATGGCCGCCT
ACAATCAGGGGACAGAATTTTGGAGGTAAATGGGAGAGATGTCACCGGACGAACCCAGGAAGAGCTTGTGGCCATGCTCAGGAGCACCAA
GCAGGGGGAGACAGCATCGCTGGTCATTGCCCGCCAAGAAGGACATTTTCTGCCCCGAGAGTTGCAACAGGGAGCTGCCACCACCGTGTA
CTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGA
AGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGA
TGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAG
AGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTC
TGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCC
CTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCAC
TGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTC
ATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACA
CCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAG
ATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGG
GGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTG

>In-frame_ENST00000462231_ENST00000539474_TCGA-49-6744-01A_PARD3B_chr2_205990461_+_WWOX_chr16_79245505_length(amino acids)=573AA_start in transcript=61_stop in transcript=1782
MGPPAPGVLREWGLRPRGQTPVRPGPAWSPGARMKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGG
ILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGP
PADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIE
DNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSG
LKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILP
KGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELQQGAATTVYCAAVPELEGLGGMYFNNCCR

--------------------------------------------------------------
>In-frame_ENST00000349953_ENST00000539474_TCGA-49-6744-01A_PARD3B_chr2_205990461_+_WWOX_chr16_79245505_length(transcript)=2494nt_BP=1434nt
ATGAAAGTGACCGTGTGCTTCGGCAGGACGGGCATCGTGGTGCCCTGCAAGGAGGGCCAGCTGCGCGTCGGCGAGCTCACCCAGCAGGCG
CTGCAGCGGTACCTGAAGACCCGGGAGAAGGGTCCTGGTTACTGGGTGAAGATTCATCACTTAGAATATACAGATGGAGGAATCCTGGAT
CCAGATGATGTCTTGGCAGATGTTGTTGAAGATAAAGACAAGCTGATTGCTGTGTTTGAAGAACAAGAACCACTCCACAAGATTGAGAGC
CCCAGTGGAAACCCTGCAGATCGGCAGAGCCCAGATGCTTTTGAGACAGAAGTGGCCGCCCAACTGGCCGCATTTAAGCCAATTGGTGGG
GAGATTGAAGTAACCCCTTCTGCTCTAAAACTAGGCACTCCACTGCTGGTGAGGAGAAGCAGTGACCCAGTGCCAGGCCCACCTGCTGAT
ACCCAGCCAAGCGCTTCACACCCTGGTGGCCAGAGTCTGAAACTGGTTGTTCCAGATTCCACGCAGAACTTGGAAGACAGAGAAGTTTTG
AATGGTGTACAGACAGAACTACTAACTTCGCCAAGAACTAAGGACACATTGAGTGATATGACAAGAACAGTGGAGATTTCTGGGGAAGGA
GGCCCATTGGGAATACATGTAGTGCCCTTCTTTTCATCTCTGAGTGGAAGGATTCTAGGACTCTTCATCCGAGGCATTGAAGACAACAGC
AGGTCCAAGCGGGAGGGACTATTTCACGAAAATGAATGTATTGTAAAAATCAACAATGTGGATCTCGTAGACAAAACCTTTGCTCAGGCT
CAAGATGTCTTCCGCCAGGCAATGAAATCTCCAAGTGTGCTCCTCCACGTGCTTCCTCCACAAAACCGTGAACAGTATGAAAAGTCAGTC
ATTGGCTCTCTTAACATTTTTGGTAATAATGATGGCGTTTTGAAAACCAAAGTGCCGCCTCCTGTCCATGGAAAATCGGGACTAAAGACA
GCAAATCTCACAGGAACCGATAGTCCTGAAACAGATGCATCAGCTTCCCTGCAACAAAACAAGAGTCCCCGAGTACCAAGGCTGGGAGGA
AAACCATCCTCTCCCTCACTCTCGCCTCTCATGGGATTTGGCAGCAATAAAAATGCAAAGAAAATTAAGATTGACCTAAAGAAAGGCCCT
GAAGGACTTGGTTTCACTGTGGTTACCAGAGACTCTTCCATACATGGTCCCGGTCCCATTTTTGTAAAAAACATTTTACCAAAGGGAGCA
GCAATAAAAGATGGCCGCCTACAATCAGGGGACAGAATTTTGGAGGTAAATGGGAGAGATGTCACCGGACGAACCCAGGAAGAGCTTGTG
GCCATGCTCAGGAGCACCAAGCAGGGGGAGACAGCATCGCTGGTCATTGCCCGCCAAGAAGGACATTTTCTGCCCCGAGAGTTGCAACAG
GGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCC
TCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGC
TAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCC
CTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCT
GGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGG
TGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCA
GCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTG
ATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGC
CAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCT
ATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAG
AATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACAT

>In-frame_ENST00000349953_ENST00000539474_TCGA-49-6744-01A_PARD3B_chr2_205990461_+_WWOX_chr16_79245505_length(amino acids)=540AA_start in transcript=0_stop in transcript=1622
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIES
PSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA
QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV
AMLRSTKQGETASLVIARQEGHFLPRELQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG

--------------------------------------------------------------
>In-frame_ENST00000358768_ENST00000539474_TCGA-49-6744-01A_PARD3B_chr2_205990461_+_WWOX_chr16_79245505_length(transcript)=2494nt_BP=1434nt
ATGAAAGTGACCGTGTGCTTCGGCAGGACGGGCATCGTGGTGCCCTGCAAGGAGGGCCAGCTGCGCGTCGGCGAGCTCACCCAGCAGGCG
CTGCAGCGGTACCTGAAGACCCGGGAGAAGGGTCCTGGTTACTGGGTGAAGATTCATCACTTAGAATATACAGATGGAGGAATCCTGGAT
CCAGATGATGTCTTGGCAGATGTTGTTGAAGATAAAGACAAGCTGATTGCTGTGTTTGAAGAACAAGAACCACTCCACAAGATTGAGAGC
CCCAGTGGAAACCCTGCAGATCGGCAGAGCCCAGATGCTTTTGAGACAGAAGTGGCCGCCCAACTGGCCGCATTTAAGCCAATTGGTGGG
GAGATTGAAGTAACCCCTTCTGCTCTAAAACTAGGCACTCCACTGCTGGTGAGGAGAAGCAGTGACCCAGTGCCAGGCCCACCTGCTGAT
ACCCAGCCAAGCGCTTCACACCCTGGTGGCCAGAGTCTGAAACTGGTTGTTCCAGATTCCACGCAGAACTTGGAAGACAGAGAAGTTTTG
AATGGTGTACAGACAGAACTACTAACTTCGCCAAGAACTAAGGACACATTGAGTGATATGACAAGAACAGTGGAGATTTCTGGGGAAGGA
GGCCCATTGGGAATACATGTAGTGCCCTTCTTTTCATCTCTGAGTGGAAGGATTCTAGGACTCTTCATCCGAGGCATTGAAGACAACAGC
AGGTCCAAGCGGGAGGGACTATTTCACGAAAATGAATGTATTGTAAAAATCAACAATGTGGATCTCGTAGACAAAACCTTTGCTCAGGCT
CAAGATGTCTTCCGCCAGGCAATGAAATCTCCAAGTGTGCTCCTCCACGTGCTTCCTCCACAAAACCGTGAACAGTATGAAAAGTCAGTC
ATTGGCTCTCTTAACATTTTTGGTAATAATGATGGCGTTTTGAAAACCAAAGTGCCGCCTCCTGTCCATGGAAAATCGGGACTAAAGACA
GCAAATCTCACAGGAACCGATAGTCCTGAAACAGATGCATCAGCTTCCCTGCAACAAAACAAGAGTCCCCGAGTACCAAGGCTGGGAGGA
AAACCATCCTCTCCCTCACTCTCGCCTCTCATGGGATTTGGCAGCAATAAAAATGCAAAGAAAATTAAGATTGACCTAAAGAAAGGCCCT
GAAGGACTTGGTTTCACTGTGGTTACCAGAGACTCTTCCATACATGGTCCCGGTCCCATTTTTGTAAAAAACATTTTACCAAAGGGAGCA
GCAATAAAAGATGGCCGCCTACAATCAGGGGACAGAATTTTGGAGGTAAATGGGAGAGATGTCACCGGACGAACCCAGGAAGAGCTTGTG
GCCATGCTCAGGAGCACCAAGCAGGGGGAGACAGCATCGCTGGTCATTGCCCGCCAAGAAGGACATTTTCTGCCCCGAGAGTTGCAACAG
GGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCC
TCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGC
TAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCC
CTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCT
GGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGG
TGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCA
GCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTG
ATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGC
CAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCT
ATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAG
AATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACAT

>In-frame_ENST00000358768_ENST00000539474_TCGA-49-6744-01A_PARD3B_chr2_205990461_+_WWOX_chr16_79245505_length(amino acids)=540AA_start in transcript=0_stop in transcript=1622
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIES
PSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA
QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV
AMLRSTKQGETASLVIARQEGHFLPRELQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG

--------------------------------------------------------------
>In-frame_ENST00000351153_ENST00000539474_TCGA-49-6744-01A_PARD3B_chr2_205990461_+_WWOX_chr16_79245505_length(transcript)=2494nt_BP=1434nt
ATGAAAGTGACCGTGTGCTTCGGCAGGACGGGCATCGTGGTGCCCTGCAAGGAGGGCCAGCTGCGCGTCGGCGAGCTCACCCAGCAGGCG
CTGCAGCGGTACCTGAAGACCCGGGAGAAGGGTCCTGGTTACTGGGTGAAGATTCATCACTTAGAATATACAGATGGAGGAATCCTGGAT
CCAGATGATGTCTTGGCAGATGTTGTTGAAGATAAAGACAAGCTGATTGCTGTGTTTGAAGAACAAGAACCACTCCACAAGATTGAGAGC
CCCAGTGGAAACCCTGCAGATCGGCAGAGCCCAGATGCTTTTGAGACAGAAGTGGCCGCCCAACTGGCCGCATTTAAGCCAATTGGTGGG
GAGATTGAAGTAACCCCTTCTGCTCTAAAACTAGGCACTCCACTGCTGGTGAGGAGAAGCAGTGACCCAGTGCCAGGCCCACCTGCTGAT
ACCCAGCCAAGCGCTTCACACCCTGGTGGCCAGAGTCTGAAACTGGTTGTTCCAGATTCCACGCAGAACTTGGAAGACAGAGAAGTTTTG
AATGGTGTACAGACAGAACTACTAACTTCGCCAAGAACTAAGGACACATTGAGTGATATGACAAGAACAGTGGAGATTTCTGGGGAAGGA
GGCCCATTGGGAATACATGTAGTGCCCTTCTTTTCATCTCTGAGTGGAAGGATTCTAGGACTCTTCATCCGAGGCATTGAAGACAACAGC
AGGTCCAAGCGGGAGGGACTATTTCACGAAAATGAATGTATTGTAAAAATCAACAATGTGGATCTCGTAGACAAAACCTTTGCTCAGGCT
CAAGATGTCTTCCGCCAGGCAATGAAATCTCCAAGTGTGCTCCTCCACGTGCTTCCTCCACAAAACCGTGAACAGTATGAAAAGTCAGTC
ATTGGCTCTCTTAACATTTTTGGTAATAATGATGGCGTTTTGAAAACCAAAGTGCCGCCTCCTGTCCATGGAAAATCGGGACTAAAGACA
GCAAATCTCACAGGAACCGATAGTCCTGAAACAGATGCATCAGCTTCCCTGCAACAAAACAAGAGTCCCCGAGTACCAAGGCTGGGAGGA
AAACCATCCTCTCCCTCACTCTCGCCTCTCATGGGATTTGGCAGCAATAAAAATGCAAAGAAAATTAAGATTGACCTAAAGAAAGGCCCT
GAAGGACTTGGTTTCACTGTGGTTACCAGAGACTCTTCCATACATGGTCCCGGTCCCATTTTTGTAAAAAACATTTTACCAAAGGGAGCA
GCAATAAAAGATGGCCGCCTACAATCAGGGGACAGAATTTTGGAGGTAAATGGGAGAGATGTCACCGGACGAACCCAGGAAGAGCTTGTG
GCCATGCTCAGGAGCACCAAGCAGGGGGAGACAGCATCGCTGGTCATTGCCCGCCAAGAAGGACATTTTCTGCCCCGAGAGTTGCAACAG
GGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCC
TCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGC
TAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCC
CTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCT
GGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGG
TGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCA
GCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTG
ATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGC
CAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCT
ATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAG
AATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACAT

>In-frame_ENST00000351153_ENST00000539474_TCGA-49-6744-01A_PARD3B_chr2_205990461_+_WWOX_chr16_79245505_length(amino acids)=540AA_start in transcript=0_stop in transcript=1622
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIES
PSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA
QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV
AMLRSTKQGETASLVIARQEGHFLPRELQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PARD3B-WWOX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneWWOXchr2:205990461chr16:79245505ENST0000035586006125_4140190.0MAPT
TgeneWWOXchr2:205990461chr16:79245505ENST00000408984010125_4140311.6666666666667MAPT
TgeneWWOXchr2:205990461chr16:79245505ENST0000056981801125_414037.0MAPT


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneWWOXchr2:205990461chr16:79245505ENST0000040265535125_414136.33333333333334312.0MAPT
TgeneWWOXchr2:205990461chr16:79245505ENST0000040688446125_414172.0235.0MAPT
TgeneWWOXchr2:205990461chr16:79245505ENST0000056678079125_414352.0415.0MAPT


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PARD3B-WWOX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PARD3B-WWOX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePARD3BC1535926Neurodevelopmental Disorders1CTD_human
TgeneWWOXC0279626Squamous cell carcinoma of esophagus3CTD_human;ORPHANET
TgeneWWOXC3280452SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 122GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneWWOXC4015519EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 282CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneWWOXC0002395Alzheimer's Disease1CTD_human
TgeneWWOXC0006142Malignant neoplasm of breast1CTD_human
TgeneWWOXC0007137Squamous cell carcinoma1CTD_human
TgeneWWOXC0011265Presenile dementia1CTD_human
TgeneWWOXC0024623Malignant neoplasm of stomach1CTD_human
TgeneWWOXC0038356Stomach Neoplasms1CTD_human
TgeneWWOXC0042076Urologic Neoplasms1CTD_human
TgeneWWOXC0087031Juvenile-Onset Still Disease1CTD_human
TgeneWWOXC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneWWOXC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneWWOXC0546126Acute Confusional Senile Dementia1CTD_human
TgeneWWOXC0678222Breast Carcinoma1CTD_human
TgeneWWOXC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneWWOXC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneWWOXC0751571Cancer of Urinary Tract1CTD_human
TgeneWWOXC1257931Mammary Neoplasms, Human1CTD_human
TgeneWWOXC1458155Mammary Neoplasms1CTD_human
TgeneWWOXC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneWWOXC3495559Juvenile arthritis1CTD_human
TgeneWWOXC3714758Juvenile psoriatic arthritis1CTD_human
TgeneWWOXC451074446,XY partial gonadal dysgenesis1ORPHANET
TgeneWWOXC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneWWOXC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneWWOXC4704874Mammary Carcinoma, Human1CTD_human