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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PARG-BMS1 (FusionGDB2 ID:62341)

Fusion Gene Summary for PARG-BMS1

check button Fusion gene summary
Fusion gene informationFusion gene name: PARG-BMS1
Fusion gene ID: 62341
HgeneTgene
Gene symbol

PARG

BMS1

Gene ID

8505

9790

Gene namepoly(ADP-ribose) glycohydrolaseBMS1 ribosome biogenesis factor
SynonymsPARG99ACC|BMS1L
Cytomap

10q11.23

10q11.21

Type of geneprotein-codingprotein-coding
Descriptionpoly(ADP-ribose) glycohydrolasemitochondrial poly(ADP-ribose) glycohydrolasepoly(ADP-ribose) glycohydrolase 60 kDa isoformribosome biogenesis protein BMS1 homologBMS1 homolog, ribosome assembly proteinBMS1-like, ribosome assembly proteinribosome assembly protein BMS1 homolog
Modification date2020031320200313
UniProtAcc.

Q14692

Ensembl transtripts involved in fusion geneENST00000402038, ENST00000492350, 
ENST00000374518, 
Fusion gene scores* DoF score4 X 3 X 4=486 X 6 X 3=108
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PARG [Title/Abstract] AND BMS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPARG(51093249)-BMS1(43287075), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePARG

GO:1990966

ATP generation from poly-ADP-D-ribose

27257257


check buttonFusion gene breakpoints across PARG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BMS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4DLBCTCGA-FA-A7DSPARGchr10

51093249

-BMS1chr10

43287075

+
ChimerDB4KIRPTCGA-J7-8537PARGchr10

51093249

-BMS1chr10

43287075

+
ChimerDB4STADTCGA-HU-8610-01APARGchr10

51093249

-BMS1chr10

43287075

+
ChimerDB4THCATCGA-DJ-A2Q3-01APARGchr10

51093249

-BMS1chr10

43287075

+


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Fusion Gene ORF analysis for PARG-BMS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000402038ENST00000374518PARGchr10

51093249

-BMS1chr10

43287075

+
intron-3CDSENST00000492350ENST00000374518PARGchr10

51093249

-BMS1chr10

43287075

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000402038PARGchr1051093249-ENST00000374518BMS1chr1043287075+7429375935871192

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000402038ENST00000374518PARGchr1051093249-BMS1chr1043287075+0.000358710.9996413

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Fusion Genomic Features for PARG-BMS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PARGchr1051093248-BMS1chr1043287074+0.0368842930.96311575
PARGchr1051093248-BMS1chr1043287074+0.0368842930.96311575
PARGchr1051093248-BMS1chr1043287074+0.0368842930.96311575
PARGchr1051093248-BMS1chr1043287074+0.0368842930.96311575

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PARG-BMS1


check button Go to

FGviewer for the breakpoints of chr10:51093249-chr10:43287075

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BMS1

Q14692

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus. {ECO:0000250|UniProtKB:Q08965}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARGchr10:51093249chr10:43287075ENST00000402038-41410_16125.0492.0MotifNuclear localization signal
HgenePARGchr10:51093249chr10:43287075ENST00000402038-41476_83125.0492.0MotifPIP-box (PCNA interacting peptide)
TgeneBMS1chr10:51093249chr10:43287075ENST00000374518423219_228212.01283.0RegionG5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARGchr10:51093249chr10:43287075ENST00000402038-4141_456125.0492.0RegionA-domain
HgenePARGchr10:51093249chr10:43287075ENST00000402038-414610_795125.0492.0RegionCatalytic
HgenePARGchr10:51093249chr10:43287075ENST00000402038-414726_727125.0492.0RegionSubstrate binding
HgenePARGchr10:51093249chr10:43287075ENST00000402038-414869_874125.0492.0RegionSubstrate binding
TgeneBMS1chr10:51093249chr10:43287075ENST0000037451842380_245212.01283.0DomainBms1-type G
TgeneBMS1chr10:51093249chr10:43287075ENST00000374518423117_121212.01283.0RegionG2
TgeneBMS1chr10:51093249chr10:43287075ENST00000374518423132_135212.01283.0RegionG3
TgeneBMS1chr10:51093249chr10:43287075ENST00000374518423184_187212.01283.0RegionG4
TgeneBMS1chr10:51093249chr10:43287075ENST0000037451842389_96212.01283.0RegionG1


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Fusion Gene Sequence for PARG-BMS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000402038_ENST00000374518_TCGA-FA-A7DS_PARG_chr10_51093249_-_BMS1_chr10_43287075_length(transcript)=7429nt_BP=375nt
GTAGATCTTTTGCGAGCAGGAGAAGTTCCTAAACCTTTTCCAACACATTATAAAGATTTGTGGGATAACAAGCATGTTAAAATGCCTTGT
TCAGAACAAAATTTGTACCCAGTGGAAGATGAGAATGGTGAGCGAACTGCGGGGAGCCGGTGGGAGCTCATTCAGACTGCACTTCTCAAC
AAATTTACACGACCCCAAAACTTGAAGGATGCTATTCTGAAATACAATGTGGCATATTCTAAGAAATGGGACTTTACAGCTTTGATCGAT
TTCTGGGATAAGGTACTTGAAGAAGCAGAAGCTCAACATTTATATCAGTCCATCTTGCCTGATATGGTGAAAATTGCACTCTGTCTGCCA
AATATTTGCACCCAGGGTGCCAAGCTGTTCTACCTTTCTGGAATGGTGCATGGAGAATATCAAAACCAAGAAATCCACAATCTGGGCCGT
TTTATTACAGTTATGAAGTTTAGGCCTCTCACATGGCAAACTTCTCACCCTTATATCCTGGCAGACAGGATGGAAGATTTGACAAACCCA
GAGGATATCCGAACAAACATCAAATGTGACCGGAAGGTGTCACTTTATGGTTATTTAAGAGGAGCACACTTGAAAAATAAAAGCCAAATT
CACATGCCAGGGGTAGGAGATTTTGCCGTGAGTGACATCAGTTTCCTCCCAGACCCTTGCGCTCTTCCTGAACAACAAAAGAAGCGCTGT
TTAAATGAGAAGGAGAAGCTGGTTTATGCGCCTCTTTCTGGAGTTGGGGGTGTGCTGTATGACAAAGACGCTGTCTATGTTGACCTTGGT
GGCAGCCACGTTTTTCAGGATGAAGTGGGGCCCACCCATGAGCTGGTCCAGAGTCTCATCTCTACCCACTCCACCATTGATGCCAAGATG
GCTTCAAGTCGAGTGACGCTGTTTTCTGATTCCAAGCCACTTGGGTCAGAGGATATAGATAATCAAGGGCTAATGATGCCAAAGGAGGAA
AAACAAATGGACTTGAACACTGGTCGAATGCGTCGGAAAGCCATTTTCGGAGATGAAGATGAATCTGGAGATAGTGATGATGAAGAAGAT
GATGAAATGTCTGAAGATGACGGGTTGGAAAACGGCTCTAGTGATGAGGAAGCAGAAGAGGAGGAAAATGCTGAGATGACTGATCAGTAT
ATGGCTGTTAAGGGCATCAAACGACGGAAACTTGAGTTGGAAGAAGACAGTGAAATGGATTTGCCAGCATTTGCTGACAGTGACGATGAC
CTTGAGAGGAGCTCAGCGGAAGAAGGGGAAGCGGAGGAAGCTGATGAAAGCAGTGAAGAAGAGGACTGCACTGCAGGAGAGAAGGGCATT
TCAGGATCAAAGGCTGCTGGAGAAGGTAGTAAAGCAGGGCTGTCACCAGCTAATTGCCAGAGTGACCGTGTGAATCTGGAGAAGTCTTTG
CTGATGAAGAAAGCAGCTCTCCCCACTTTCGATTCTGGGCATTGCACAGCTGAAGAGGTGTTTGCATCTGAAGATGAATCTGAAGAAAGC
TCCTCACTCAGTGCAGAGGAAGAAGACTCAGAAAATGAAGAGGCTATTAGAAAAAAGCTTTCAAAGCCTTCTCAAGTGAGCAGTGGTCAG
AAACTGGGGCCACAGAACTTCATTGATGAGACCAGTGATATAGAAAATTTACTCAAAGAGGAAGAAGATTACAAGGAAGAAAATAATGAT
TCCAAAGAAACGTCAGGTGCCCTCAAGTGGAAGGAAGACCTTTCCAGAAAGGCAGCTGAGGCCTTTCTGAGGCAGCAGCAAGCAGCTCCA
AACCTCCGAAAGCTTATTTATGGGACAGTGACAGAAGATAATGAAGAAGAAGATGATGATACTCTAGAAGAGCTTGGAGGGTTGTTTCGT
GTCAACCAGCCTGACAGAGAGTGTAAGCACAAGGCTGACTCTTTGGACTGCTCCAGATTTCTTGTGGAGGCCCCCCATGACTGGGATTTA
GAGGAGGTTATGAACAGTATCAGAGATTGCTTCGTGACTGGAAAGTGGGAAGATGATAAAGATGCAGCCAAGGTCTTAGCAGAAGATGAG
GAGCTCTACGGTGACTTTGAAGACTTGGAAACAGGGGACGTGCACAAGGGAAAATCAGGCCCCAATACTCAGAATGAAGATATAGAGAAA
GAAGTTAAGGAAGAAATTGACCCCGACGAAGAAGAAAGTGCCAAGAAAAAGCATTTGGATAAGAAGAGAAAATTGAAGGAGATGTTTGAT
GCAGAATATGATGAAGGAGAAAGCACATATTTTGATGATCTTAAAGGAGAAATGCAGAAACAAGCACAGCTGAATCGCGCAGAATTTGAA
GATCAAGATGATGAAGCCAGAGTTCAGTATGAGGGTTTTCGACCTGGGATGTACGTCCGCATTGAGATTGAAAATGTTCCCTGTGAATTT
GTGCAGAACTTTGACCCCCATTACCCCATTATCCTGGGTGGCTTGGGCAACAGTGAGGGAAATGTTGGCTACGTGCAGATGCGTCTGAAG
AAACATCGCTGGTATAAGAAAATCCTCAAGTCCCGAGATCCAATCATATTTTCTGTAGGGTGGAGGAGGTTTCAGACCATCCCACTGTAT
TATATCGAAGACCACAATGGAAGACAAAGGCTTCTAAAGTATACCCCACAGCACATGCATTGCGGAGCAGCCTTTTGGGGCCCTATCACT
CCACAGGGAACTGGTTTCTTGGCAATACAGTCTGTCAGTGGCATAATGCCTGATTTTCGGATAGCTGCTACAGGAGTTGTCCTTGATCTG
GATAAATCCATAAAAATTGTGAAGAAATTAAAGCTAACTGGTTTTCCATATAAAATTTTCAAGAACACTTCATTTATTAAGGGAATGTTT
AATTCTGCCTTGGAAGTGGCCAAATTTGAAGGTGCTGTGATTCGAACAGTCAGTGGGATAAGGGGGCAGATCAAGAAAGCACTCCGAGCT
CCAGAAGGAGCTTTCAGGGCCAGCTTTGAGGATAAGCTGCTGATGAGCGATATTGTCTTCATGCGAACTTGGTATCCTGTTTCCATCCCA
GCGTTCTATAACCCAGTAACATCTTTGTTGAAACCAGTGGGTGAGAAAGACACCTGGTCAGGAATGCGGACCACGGGCCAACTCAGGCTC
GCCCATGGCGTCAGACTAAAGGCGAACAAGGACTCTCTGTATAAGCCAATCCTGAGGCAAAAGAAACATTTTAATTCACTGCACATTCCA
AAAGCCTTGCAGAAGGCCCTGCCATTTAAGAACAAGCCCAAGACCCAAGCAAAGGCAGGCAAGGTGCCAAAGGACAGGCGGAGACCGGCC
GTCATACGCGAGCCTCATGAAAGAAAGATCCTTGCACTGCTGGATGCTCTGAGTACGGTGCATAGTCAGAAGATGAAGAAGGCCAAGGAG
CAGCGGCACCTGCACAATAAAGAGCACTTCAGAGCCAAGCAGAAGGAGGAGGAGGAGAAGCTGAAGCGGCAGAAGGACCTCAGGAAGAAG
CTCTTCAGAATTCAGGGGCAGAAGGAAAGAAGAAACCAGAAGTCCAGTTTGAAGGGGGCTGAGGGCCAATTGCAGTGAGCCTTTGGACTG
GAGGGACTGTCCCTGGATCTGCGGAGGTAGACAGTTTCAAACATCACAGTTTGAATGCCTGTGAATGACAAGTCAGTGGGAAAGAGCTCA
AGAGATGTCTCTACTCAAACTGTGCCTGCAGGAGGAGGAACAGAGAAGCCTGGGCTGCTGGGACTGGGTTCATTCTCATGACTTGGGGCT
GTCGAGATTTAAAGTGATGTAAGCTGTGGTTATGTGGATTCTCTTACTTTCCTCTGCCTGCCTCAGTTTAATTATTTTGTCCTACAGAAA
TATCATTAAAATATTTTTTTGTTACTTTTGGCTTAGTAGTTTTCATTAGGGATGAATGCCTGACAATTCTTTGTGGATAATTATTTATAC
TACCACCTTCATGAGGAGTCTTCCAGAAGAGAAAGAAATATTCACTTGAACTCTGAGCTCCCATGGAAGATTTTAGAGAATAGTGTGTAG
TGTTTTTGTTTTGTTTTTTGTTTGAGTGACACACAAACCTAGATGGTACAGCCTACTGTGCACCCAGGATCTATGGGCTCCTTTGATCAC
TGGCCCTTGTGGACATTTTCTATCTTATTTCATATGTTCTGCACATTAGTATAGTGACAAGGTAACAGTAAGTACTTTTTTAAAGCTTTA
GACTTAGGAGATTATTGTCTCAGGTGCAGAGACCAAGGAAATCGTATGTATCAGTGAGATAGGCTTCCCGTATTATGCTCATGCGTTATA
CCTGCCTAGCTACATTGCCTTTTTTTAAATTAAACATTATGTTGAAGTAATCATACTATTACATAGGCGATGTATGTATTTTATGATTGT
ATGTTGATATAGTTATGGGGAATCTATTCCTATACGATGTAATCATAGATTCACATATAGTTGTATATTTTGCCCAATTTCTCTCAGTGG
TAATGTTTCACACATATAACAATCAGGATGTTGACATCAATACAGCCCGCTGATTTTATTCACATTTCCCCAGCTTTACTTTCCCCAACG
TATACTCCTCCATGTATGCATGGGTGTGTAGAAATATGGAACGCAGCTGGGCACAGTGACTCACGCCTGTAATCCCAGCACTTTGGGATG
CTAAGGCAGGAGGATCACTTGAGCCCAGGAATTTGAGACCAACTTGGGCAACATGGCAAAACCTCATCGCTACAAAAAATAAAAAATTCG
CCAGGTGTGGTGGGTGCACACCTGTAGTTCCAGCTGCTTGGGAGGCTGAGGTAGGAGGATCACTTGAGCTTGGGAGGTTGAGGCTGCAGT
GAGCCATGATAGCACCACTGCACTCCAGCCTGGGCGACAGGGCAAGACCCTGTTTCAAAAAAAAAAAATTATACATATATGTATGTAGAA
CACTTCATGAATTTGTGTGTCATCTGTGCATGGGGCCCATGCTGACCTCTGTGTTGTGCCAGTTATAGTATGTGTGCTGCTGATATGAGT
GCCACATTGCCTTTACAACATCATAGGGGCCAAAGAGGGTTGGCAGGATTATGAGCAGTTGGCCTAGTCTGAGAGGCTCTCTAAAAGCCT
AAAGTCTGTAGGCAGGTGCTCAGCTTTGTATCTCCATAAGAAGGGAAGAGGATGTGAGGATCCTGTCAGGGCTAGGTCCACCTGGGAAGT
GACAATTGGAACACTCCCAGACCTCTCTGGGCAACTCTGGGTGTACATTTTCCTCTGTTCCTCAAGAGCTATTATGAATTTCATCATCCA
TTATGCTGATAGGCCTGGGGACTGACACATAGTAAGCCCATAACAATTATAATTTAAAACTAATTTGTTATATAGCATAATTGATATATT
TTAAAATGCAAAACTATAATTCAACTAAAATATACAAGGCACTCAAGTCATACCATGTTTTAAGTAGCTTACAAGGTGATCAGCAAGTGT
CTTATACAACAAGCAAATTTGTTCAAAGAGAAGCATTGCAAATAAGTATTTATAATTGTATAGTTTTATATTTTAGCCAGAAGAGTGGAA
TCCTTTAGCAATGGGGGAAATAAAAGAATGTTTAATTACAGTTGCAGATAATTGCCTTTTCCAAAGACAATGTATGTAGGCAGAACTCAT
ACCTGTTAATATTAAAAATCTTGGTTTATCATATTTGGAGAACAAGGGAAATAAAAAGTTTGCATATTAAGATTATTTAAACTAAAGTTA
AGGAATCTCTAATGTCTGAAAGAAACAATAAATAGCATTTTTCATGTAGAATTTTTATTGGTGAAGGTTCCACCTGGCCAGGTTAGTAAA
ATACAGTCACACATCAGTTAAGGATGGGGATATATTCTGAGAAATGTATCATTAGGCAATTTTGTCATTGTGTAAACATCATAGAGTGAC
ACACAAACCTAGATGGTACAGCCTACTGTGCACCTGGGCTCTATGGTATGGCCTGTTGCTCCTAGGCTACAAACCTGGGCAGCATGTGAC
TGTACTGACTACTGTAGGCAGTTGTAACACAGTGGTAAACATTTGTGTATCGAAACATAGAAAAGGCGTAGCAAAAATACAGTATTGTGG
AACCACTGCCATATACGTGGTCCATCCTTGACTGAACATCATGCGGCATGTGGCTGTATGTATACACATAGTTTTTGCTGTGAGTTTGCA
TCCATCTCATAGGAAGACATATATCAAAATAAGGACCAGACTGGAGAGTGTGTAAATTACTTTTCAATACTAATGGCTTATTAATTTGAT
ATTGTCAGCAAGTATGTTGCAAAAACAAATTCCACCAGAATGTGAGTTCCATGAGAGCAGGAACTGGGTTGTTCACCTTGTTGGCACTTG
GAGTAGAGCCACTGAGCTTCGTGCTGCATAAAATTGCTTGGAAGAAAGAAGGGAGGGCATTCCAGGTAACTGAAGCATTGCTATGCAAAG
TAAGCATTTGCCCTCTGAAATATTTTAACAATGTTTATAGAAACCTTTCTCAATTGTATTAAACTTTGTAAATTGTAAAAATTATTCTGT
TATACCTTTTCTATTTACTAGGCACAGGCAGCCATAGGTGCTAGGTATGTTTTGAAAACATATTGAACCTACAGTGTACATATCATTCCA
TGCCATTAAATATTCTTATTTAATCATAGATGTGTTCAGGTGTGTTTGGTTTCCTATTTGTGGATGTACTAGATTGTTTTCTTTTTTTAA
CAAAACCTGTGAACTTGCTTTAAGTATTATCATTTGGTGACATGCCCGCCATTTCAGAAATAAATGTTTGAGCAAAGAGGAAAGCCACCG
GGTCTGATTCAGCTCTCTGGAGGCTCCAGAGCTTACCTCGCTGATGGGAAAAAGAGCATCGATTTAATTGCCCTTGGTACCGACTTCTAG
TATCTAGTATTTTGCCAGACTCAGGTATTTCTTAAAGCCATTATTCAGAGTCTTCAGCAAGGACATTGTATTTTACTTGTGTCTCCTTAG
TTTTACCTAGTTTATTTCATGGTTTTAAAGTATTGTACATTTTTATAATCCTTTAACAAGACAAAAGGTTGAGATGTTGGACATTTAAAT
GCCAAAGGTGTTTTATTATGAGACTTAGCATTTCATATTTGGGGATGGTACCTTATCGAAAATCAGATAAACTTTGGTTGGATGGGTATT
TGGAGGAATCTTTTAAGTCTTTTCTTAAGCAAAGTTTGGACACTCTAAAATAAGGTTGCCAACTGGCATGTAGAGAGAAAAGGATGTGTC
ATACATTTAGACCAGGTGGCCTGTCCTGTAAATTTTTTTGAGGGGAGGGGTGGGCTTGTTTTTTTCTGTGTTTCGGTTTTTTCCAATTTT

>In-frame_ENST00000402038_ENST00000374518_TCGA-FA-A7DS_PARG_chr10_51093249_-_BMS1_chr10_43287075_length(amino acids)=1192AA_start in transcript=9_stop in transcript=3587
MRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWD
KVLEEAEAQHLYQSILPDMVKIALCLPNICTQGAKLFYLSGMVHGEYQNQEIHNLGRFITVMKFRPLTWQTSHPYILADRMEDLTNPEDI
RTNIKCDRKVSLYGYLRGAHLKNKSQIHMPGVGDFAVSDISFLPDPCALPEQQKKRCLNEKEKLVYAPLSGVGGVLYDKDAVYVDLGGSH
VFQDEVGPTHELVQSLISTHSTIDAKMASSRVTLFSDSKPLGSEDIDNQGLMMPKEEKQMDLNTGRMRRKAIFGDEDESGDSDDEEDDEM
SEDDGLENGSSDEEAEEEENAEMTDQYMAVKGIKRRKLELEEDSEMDLPAFADSDDDLERSSAEEGEAEEADESSEEEDCTAGEKGISGS
KAAGEGSKAGLSPANCQSDRVNLEKSLLMKKAALPTFDSGHCTAEEVFASEDESEESSSLSAEEEDSENEEAIRKKLSKPSQVSSGQKLG
PQNFIDETSDIENLLKEEEDYKEENNDSKETSGALKWKEDLSRKAAEAFLRQQQAAPNLRKLIYGTVTEDNEEEDDDTLEELGGLFRVNQ
PDRECKHKADSLDCSRFLVEAPHDWDLEEVMNSIRDCFVTGKWEDDKDAAKVLAEDEELYGDFEDLETGDVHKGKSGPNTQNEDIEKEVK
EEIDPDEEESAKKKHLDKKRKLKEMFDAEYDEGESTYFDDLKGEMQKQAQLNRAEFEDQDDEARVQYEGFRPGMYVRIEIENVPCEFVQN
FDPHYPIILGGLGNSEGNVGYVQMRLKKHRWYKKILKSRDPIIFSVGWRRFQTIPLYYIEDHNGRQRLLKYTPQHMHCGAAFWGPITPQG
TGFLAIQSVSGIMPDFRIAATGVVLDLDKSIKIVKKLKLTGFPYKIFKNTSFIKGMFNSALEVAKFEGAVIRTVSGIRGQIKKALRAPEG
AFRASFEDKLLMSDIVFMRTWYPVSIPAFYNPVTSLLKPVGEKDTWSGMRTTGQLRLAHGVRLKANKDSLYKPILRQKKHFNSLHIPKAL
QKALPFKNKPKTQAKAGKVPKDRRRPAVIREPHERKILALLDALSTVHSQKMKKAKEQRHLHNKEHFRAKQKEEEEKLKRQKDLRKKLFR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PARG-BMS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PARG-BMS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PARG-BMS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePARGC0007621Neoplastic Cell Transformation2CTD_human
HgenePARGC0012684Blastocyst Disintegration1CTD_human
HgenePARGC0013937Embryo Resorption1CTD_human
HgenePARGC0752350Embryo Death1CTD_human
HgenePARGC0752351Embryo Loss1CTD_human
HgenePARGC1136082Embryo Disintegration1CTD_human
TgeneBMS1C0282160Aplasia Cutis Congenita1CTD_human;ORPHANET;UNIPROT