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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PARN-CACHD1 (FusionGDB2 ID:62385)

Fusion Gene Summary for PARN-CACHD1

check button Fusion gene summary
Fusion gene informationFusion gene name: PARN-CACHD1
Fusion gene ID: 62385
HgeneTgene
Gene symbol

PARN

CACHD1

Gene ID

5073

57685

Gene namepoly(A)-specific ribonucleasecache domain containing 1
SynonymsDAN|DKCB6|PFBMFT4-
Cytomap

16p13.12

1p31.3

Type of geneprotein-codingprotein-coding
Descriptionpoly(A)-specific ribonuclease PARNdeadenylating nucleasedeadenylation nucleasepolyadenylate-specific ribonucleaseVWFA and cache domain-containing protein 1cache domain-containing protein 1von Willebrand factor type A and cache domain containing 1
Modification date2020031320200320
UniProtAcc.

Q5VU97

Ensembl transtripts involved in fusion geneENST00000437198, ENST00000420015, 
ENST00000341484, ENST00000539279, 
ENST00000566021, 		ENST00000371073, 
ENST00000290039, ENST00000495994, 
Fusion gene scores* DoF score15 X 15 X 6=135015 X 11 X 7=1155
# samples 1615
** MAII scorelog2(16/1350*10)=-3.07681559705083
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1155*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PARN [Title/Abstract] AND CACHD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPARN(14687158)-CACHD1(65016277), # samples:1
Anticipated loss of major functional domain due to fusion event.PARN-CACHD1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PARN-CACHD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePARN

GO:0000495

box H/ACA snoRNA 3'-end processing

22442037

HgenePARN

GO:0010587

miRNA catabolic process

25049417

HgenePARN

GO:0071051

polyadenylation-dependent snoRNA 3'-end processing

22442037


check buttonFusion gene breakpoints across PARN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CACHD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-4W-AA9S-01APARNchr16

14687158

-CACHD1chr1

65016277

+


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Fusion Gene ORF analysis for PARN-CACHD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000437198ENST00000371073PARNchr16

14687158

-CACHD1chr1

65016277

+
In-frameENST00000437198ENST00000290039PARNchr16

14687158

-CACHD1chr1

65016277

+
5CDS-3UTRENST00000437198ENST00000495994PARNchr16

14687158

-CACHD1chr1

65016277

+
In-frameENST00000420015ENST00000371073PARNchr16

14687158

-CACHD1chr1

65016277

+
In-frameENST00000420015ENST00000290039PARNchr16

14687158

-CACHD1chr1

65016277

+
5CDS-3UTRENST00000420015ENST00000495994PARNchr16

14687158

-CACHD1chr1

65016277

+
Frame-shiftENST00000341484ENST00000371073PARNchr16

14687158

-CACHD1chr1

65016277

+
Frame-shiftENST00000341484ENST00000290039PARNchr16

14687158

-CACHD1chr1

65016277

+
5CDS-3UTRENST00000341484ENST00000495994PARNchr16

14687158

-CACHD1chr1

65016277

+
In-frameENST00000539279ENST00000371073PARNchr16

14687158

-CACHD1chr1

65016277

+
In-frameENST00000539279ENST00000290039PARNchr16

14687158

-CACHD1chr1

65016277

+
5CDS-3UTRENST00000539279ENST00000495994PARNchr16

14687158

-CACHD1chr1

65016277

+
intron-3CDSENST00000566021ENST00000371073PARNchr16

14687158

-CACHD1chr1

65016277

+
intron-3CDSENST00000566021ENST00000290039PARNchr16

14687158

-CACHD1chr1

65016277

+
intron-3UTRENST00000566021ENST00000495994PARNchr16

14687158

-CACHD1chr1

65016277

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000437198PARNchr1614687158-ENST00000371073CACHD1chr165016277+618410609146861531
ENST00000437198PARNchr1614687158-ENST00000290039CACHD1chr165016277+618410609146861531
ENST00000420015PARNchr1614687158-ENST00000371073CACHD1chr165016277+60389148345401485
ENST00000420015PARNchr1614687158-ENST00000290039CACHD1chr165016277+60389148345401485
ENST00000539279PARNchr1614687158-ENST00000371073CACHD1chr165016277+56305066241321356
ENST00000539279PARNchr1614687158-ENST00000290039CACHD1chr165016277+56305066241321356

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000437198ENST00000371073PARNchr1614687158-CACHD1chr165016277+0.0001095630.99989045
ENST00000437198ENST00000290039PARNchr1614687158-CACHD1chr165016277+0.0001095630.99989045
ENST00000420015ENST00000371073PARNchr1614687158-CACHD1chr165016277+0.0001144480.99988556
ENST00000420015ENST00000290039PARNchr1614687158-CACHD1chr165016277+0.0001144480.99988556
ENST00000539279ENST00000371073PARNchr1614687158-CACHD1chr165016277+0.0001210610.9998789
ENST00000539279ENST00000290039PARNchr1614687158-CACHD1chr165016277+0.0001210610.9998789

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Fusion Genomic Features for PARN-CACHD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PARNchr1614687157-CACHD1chr165016276+1.05E-091
PARNchr1614687157-CACHD1chr165016276+1.05E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PARN-CACHD1


check button Go to

FGviewer for the breakpoints of chr16:14687158-chr1:65016277

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CACHD1

Q5VU97

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May regulate voltage-dependent calcium channels. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARNchr16:14687158chr1:65016277ENST00000341484-1324178_245245.0579.0DomainR3H
HgenePARNchr16:14687158chr1:65016277ENST00000420015-1223178_245260.0594.0DomainR3H
HgenePARNchr16:14687158chr1:65016277ENST00000437198-1324178_245306.0640.0DomainR3H
TgeneCACHD1chr16:14687158chr1:65016277ENST000003710730271243_126066.01275.0Compositional biasNote=His-rich
TgeneCACHD1chr16:14687158chr1:65016277ENST00000371073027943_98266.01275.0Compositional biasNote=Cys-rich
TgeneCACHD1chr16:14687158chr1:65016277ENST00000371073027228_44366.01275.0DomainVWFA
TgeneCACHD1chr16:14687158chr1:65016277ENST00000371073027453_53266.01275.0DomainNote=Cache 1
TgeneCACHD1chr16:14687158chr1:65016277ENST00000371073027772_85366.01275.0DomainNote=Cache 2
TgeneCACHD1chr16:14687158chr1:65016277ENST000003710730271117_127466.01275.0Topological domainCytoplasmic
TgeneCACHD1chr16:14687158chr1:65016277ENST000003710730271096_111666.01275.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCACHD1chr16:14687158chr1:65016277ENST0000037107302736_109566.01275.0Topological domainExtracellular


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Fusion Gene Sequence for PARN-CACHD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000437198_ENST00000371073_TCGA-4W-AA9S-01A_PARN_chr16_14687158_-_CACHD1_chr1_65016277_length(transcript)=6184nt_BP=1060nt
GCGCGCTGTTTCCGGAAGTCGCGGCCGGCGTCACCGCTGCGGCTGCCTCAGCTACTGCCGCAGTCGCCGCGGAATTCGGCGAGTAGAACC
GCTGAGGCGGGCGCGGGCCCGGGTGGGGCCAAGGTTCCGGCCACTCTGCAGAATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCA
CAAAGTGTACCAGGCCATAGAGGAGGCCGACTTCTTCGCCATCGATGGGGAGTTTTCAGGAATCAGTGATGGACCTTCAGTCTCTGCATT
AACAAATGGTTTTGACACTCCAGAAGAGAGGTATCAGAAGCTTAAAAAGCATTCCATGGACTTTTTGCTATTTCAGTTTGGCCTTTGCAC
TTTTAAGTATGACTACACAGATTCAAAGTATATAACGAAGTCATTTAACTTCTATGTTTTCCCGAAACCCTTCAATAGATCCTCACCAGA
TGTCAAATTTGTTTGTCAGAGCTCCAGCATTGACTTTCTAGCAAGCCAGGGATTTGATTTTAATAAAGTTTTTCGAAATGGAATTCCATA
TTTAAATCAGGAAGAAGAAAGACAGTTAAGAGAGCAGTATGATGAAAAACGTTCACAGGCGAATGGTGCAGGAGCTCTGTCCTATGTATC
TCCTAACACTTCAAAATGTCCTGTCACGATTCCTGAGGATCAAAAGAAGTTTATTGACCAAGTGGTAGAGAAAATAGAGGATTTATTACA
AAGTGAAGAAAACAAGAACTTGGATTTAGAGCCATGTACCGGGTTCCAAAGAAAACTAATTTATCAGACTTTGAGCTGGAAGTATCCGAA
AGGCATTCATGTTGAGACTTTAGAAACTGAAAAGAAGGAGCGATATATAGTTATCAGCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGA
GCAGCAGAAACATGCCAAAGAACAGGAGGAGCTGAATGATGCTGTGGGATTTTCTAGAGTCATTCACGCCATTGCTAATTCGGGAAAACT
TGTTATTGGACACAATATGCTCTTGGACGTCATGCACACAGTTCATCAGTTCTACTGCCCTCTGCCTGCGCGGATATTCAACTCCTTTGT
TTACACTGAGAAAATCTCAAATGGAGAAAGTGAAGTACAGCAGCTAGCCAAAAAAATCCGAGAGAAGTTCAACCGTTACTTGGATGTGGT
CAATCGGAACAAGCAAGTTGTAGAAGCATCCTATACGGCTCACCTAACCTCTCCCCTAACTGCAATTCAAGACTGCTGTACTATCCCACC
TTCCATGATGGAATTCGATGGGAACTTTAATACCAATGTGTCTAGAACAATTAGTTGTGATCGACTTTCTACTACTGTTAATAGCCGGGC
CTTCAATCCAGGACGAGACTTAAATTCAGTTCTTGCAGACAACCTGAAATCCAACCCTGGAATTAAGTGGCAATATTTCAGTTCAGAAGA
AGGAATTTTCACTGTTTTCCCAGCACACAAGTTCCGGTGTAAGGGCAGCTACGAACACCGCAGTAGACCCATCTACGTCTCTACAGTCCG
GCCGCAGTCAAAGCACATAGTAGTGATTCTGGACCACGGGGCTTCAGTCACAGACACTCAGCTTCAGATTGCCAAGGACGCTGCTCAGGT
CATCCTCAGCGCCATCGATGAACATGACAAGATTTCTGTGTTAACTGTGGCAGATACCGTCCGGACTTGCTCACTAGACCAGTGCTATAA
GACCTTCTTGTCTCCAGCCACCAGTGAGACAAAAAGGAAAATGTCCACCTTTGTTAGCAGCGTGAAGTCTTCAGACAGTCCTACCCAGCA
CGCAGTGGGATTCCAAAAGGCATTTCAGCTGATTCGAAGTACAAACAATAACACAAAGTTCCAAGCAAATACAGACATGGTCATCATTTA
CCTGTCAGCTGGCATTACATCAAAGGACTCTTCGGAAGAAGATAAAAAAGCGACTCTCCAAGTCATCAATGAAGAAAATAGCTTTCTAAA
CAACTCTGTAATGATTCTCACCTATGCCCTCATGAACGATGGGGTGACTGGTTTGAAAGAGCTGGCTTTTCTGAGGGATCTAGCTGAACA
GAATTCAGGGAAGTACGGTGTGCCAGACCGGATGGCCTTGCCTGTGATTAAGGGCAGCATGATGGTGCTGAATCAGTTGAGCAACCTGGA
GACCACAGTGGGCAGGTTCTACACAAACCTTCCCAACCGGATGATTGATGAAGCCGTCTTCAGCCTGCCCTTCTCTGATGAGATGGGAGA
TGGTTTGATAATGACTGTGAGTAAACCCTGTTATTTTGGAAACCTACTTCTGGGAATTGTAGGTGTGGACGTGAATCTGGCTTACATTCT
TGAAGACGTGACGTATTACCAAGACTCTTTGGCTTCCTATACTTTTCTCATAGACGACAAAGGATATACACTTATGCACCCATCTCTTAC
CAGGCCATATTTATTGTCAGAGCCCCCACTTCATACTGACATCATACATTATGAAAATATTCCAAAATTTGAATTAGTTCGGCAAAATAT
CCTAAGCCTCCCTCTGGGCAGCCAGATTATCGCAGTCCCTGTGAACTCATCCCTGTCTTGGCACATAAACAAGCTGAGAGAAACTGGAAA
GGAAGCCTACAATGTTAGCTATGCCTGGAAGATGGTACAAGACACTTCCTTTATTCTGTGTATTGTGGTGATACAACCAGAAATACCTGT
GAAACAACTGAAGAACCTCAACACTGTTCCCAGCAGCAAGCTGCTGTACCACCGGCTGGATCTCCTTGGCCAGCCCAGTGCTTGCCTCCA
CTTCAAACAGCTGGCAACCCTAGAAAGTCCCACCATCATGCTGTCTGCTGGCAGCTTTTCCTCCCCCTATGAGCACCTCAGCCAGCCAGA
GACAAAGCGCATGGTAGAGCACTACACCGCCTATCTCAGCGACAACACCCGCCTCATTGCTAACCCGGGCCTCAAATTCTCTGTCAGAAA
TGAAGTAATGGCTACCAGCCACGTCACAGATGAATGGATGACACAAATGGAAATGAGTAGCCTGAACACTTACATTGTCCGCCGTTACAT
AGCAACACCCAATGGCGTCCTCAGAATTTATCCTGGTTCCCTCATGGACAAAGCATTTGATCCCACTAGGAGACAATGGTATCTCCATGC
AGTAGCTAATCCAGGGTTGATTTCTTTGACTGGTCCTTACTTAGATGTTGGAGGAGCTGGTTATGTTGTGACAATCAGTCACACAATTCA
TTCATCCAGTACACAGCTGTCTTCTGGGCACACTGTGGCTGTGATGGGCATTGACTTCACACTCAGATACTTCTACAAAGTTCTGATGGA
CCTATTACCTGTCTGTAACCAAGATGGTGGCAACAAAATAAGGTGCTTCATAATGGAGGACAGGGGTTATCTGGTGGCGCACCCGACTCT
CATCGACCCCAAAGGACATGCACCTGTGGAGCAGCAGCACATCACCCACAAGGAGCCCCTGGTAGCAAATGATATCCTCAACCACCCCAA
CTTTGTAAAGAAAAACCTGTGCAACAGCTTCAGTGACAGAACGGTCCAGAGGTTTTATAAATTCAACACCAGCCTTGCGGGGGATTTGAC
GAACCTTGTGCATGGCAGCCACTGTTCCAAATACAGATTAGCAAGGATCCCAGGAACCAACGCGTTTGTTGGCATTGTCAACGAAACCTG
CGACTCTCTTGCCTTCTGTGCCTGCAGCATGGTGGACCGACTCTGTCTCAACTGTCACCGAATGGAACAAAATGAATGTGAATGTCCTTG
TGAGTGCCCTCTAGAGGTCAATGAGTGCACTGGCAACCTCACCAATGCAGAGAACCGAAACCCCAGCTGCGAGGTCCACCAGGAGCCGGT
GACATACACAGCTATTGACCCTGGCCTGCAAGATGCTCTTCACCAGTGTGTCAACAGCAGGTGCAGTCAGAGGCTGGAAAGTGGGGACTG
TTTTGGGGTGCTGGATTGTGAATGGTGCATGGTGGACAGTGATGGAAAGACTCACCTGGACAAACCCTACTGTGCCCCCCAGAAAGAATG
CTTCGGGGGGATTGTGGGAGCCAAAAGTCCCTACGTTGATGACATGGGAGCAATAGGTGATGAGGTGATCACATTAAACATGATTAAAAG
CGCCCCTGTGGGTCCTGTGGCTGGAGGGATCATGGGATGCATCATGGTCTTGGTCCTGGCGGTGTATGCCTACCGCCACCAGATTCATCG
CCGGAGCCATCAGCATATGTCTCCTCTTGCTGCCCAAGAAATGTCAGTGCGTATGTCCAACCTGGAGAATGACAGAGATGAAAGGGACGA
CGACAGCCACGAAGACAGAGGCATCATCAGCAACACTCGGTTTATAGCTGCGGTCATCGAACGACATGCACACAGTCCAGAAAGAAGGCG
CCGCTACTGGGGTCGATCAGGAACAGAAAGTGATCATGGTTACAGCACCATGAGCCCACAGGAGGACAGTGAAAATCCTCCATGCAACAA
TGACCCCTTGTCAGCCGGGGTCGATGTGGGAAACCATGATGAGGACTTAGACCTGGATACCCCCCCTCAGACTGCTGCCCTACTAAGTCA
CAAGTTCCACCACTACCGGTCACACCACCCTACACTTCATCATAGCCACCACTTACAGGCGGCCGTCACGGTACACACTGTCGATGCAGA
ATGCTAACAATCTCCTCACCTCCACGCCAAGATGAGATCTGGGAGCTACAGAATGTTCTGGAAAGAAAAAGAACCGGCTTAAAACCCACA
GCAAGAGACCTCCCTTGTGTTTGTGCTTTGTGCAGAGTTGTTTGAGTCATTTCCTGCCTGTCGACATGGTTAAAAACGAGAGAAACAACA
ACACAGTCACATTTGTGAAGATGTGAGGCTGGTTCTGAAATGGAGGGGAAATAAGCCTGATGAACAGACCTGCCATAACACTAATGGAAG
GTAACAGAAGGCGAACCTCCAAACACAGAGACGGAACCTGCAAGTGAAGCTGAGCCAGAGGAATGTTCCAAAGAGCCAGAAGCATTCAGC
TCTCCTTAACTGGAAGAGAGAAAAATCTGCTCACCCAGAGACTGGAATGTGGCACATGCAGATACAAATGTGTGCATTGAAGATTTCGCT
TTGTTTCTTAGCGGTACCTGGATACCACAGTTGCTGTATGGAACTCATGTTATGCTCTAAACGATGCATCTCAGAATTTCTAAGTAAAGG
ATTATTTTTCTACTATTTATTGAACTTTCAAACATTCTCAAACTTTGGGGAAAAGGAAAGGAAACACAGGAGAAGTTTTCAGCAGTTGCC
CCGAGCTGTTTTGTGTGTAATGAAGTGGTTCTTTGATTAAGGAGCTCTATTTCTTATTTAACTGATATCCCACTGCCCCACTCCACAAAA
TAGGAAAATGAAGAAATCTTTCTCTCTGACTTGTTTACATCATTTCACGGAAACACATCTTTGTTTGTAATGCAGTATTCTTTCTCTGTG
TTTGACAGAGATGGGGAGGGGCAGAGGAATTTAAGAGGTTTTAAAAGAAATGTTATGTTTCTTATGACTTGTTTCCACTCCTCGTACAAT
GCTATTCTTAGGTTTCTACGAAACCTAATGTTAGAACCGCATCCTTTCAGCTAAGGGAGGGTTGGATTTATTTTCCTTGTTTTAGAGACT
ACAAATTTTTAAATATCCCATTTTGACTGAGAATATTGACATATAAGGGAAGAAGTTTTCTAAATTGTGAAAGTCTGGTTCTTAATTAAA
GAATTTTTTTTTTAATATCACGGTTAAAAGCTGCTGCCAGTTAGCCAAGACATTATCCACCAAATTGCTTTGTGATTTATACAGGGATTA
ATCAAATCTGGCTACTATAACATGGGGCATTGTAACTTTAAAGTAGTGTTTTAATTACAGTGATGTATTTTAGACTCACATTTTGTGATT
CAAATATGTTATAAAGGCATTCTTGCACCATGGTAAAGAATGTGTGTGGTAAATCTCCGTTTATATGTAGTTGGAAAAAATTCACTGAAT
AATGTTTTAATGATAGGGTATTATGATACAATGTAAAAAACAATTGGTTCTTCAGCAGTACAGAAAGTAAACTATATATGTGCTATCAGG

>In-frame_ENST00000437198_ENST00000371073_TCGA-4W-AA9S-01A_PARN_chr16_14687158_-_CACHD1_chr1_65016277_length(amino acids)=1531AA_start in transcript=91_stop in transcript=4686
MRRARARVGPRFRPLCRMEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCT
FKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVS
PNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRRE
QQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPARIFNSFVYTEKISNGESEVQQLAKKIREKFNRYLDVV
NRNKQVVEASYTAHLTSPLTAIQDCCTIPPSMMEFDGNFNTNVSRTISCDRLSTTVNSRAFNPGRDLNSVLADNLKSNPGIKWQYFSSEE
GIFTVFPAHKFRCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASVTDTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQCYK
TFLSPATSETKRKMSTFVSSVKSSDSPTQHAVGFQKAFQLIRSTNNNTKFQANTDMVIIYLSAGITSKDSSEEDKKATLQVINEENSFLN
NSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKYGVPDRMALPVIKGSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFSDEMGD
GLIMTVSKPCYFGNLLLGIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFELVRQNI
LSLPLGSQIIAVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTSFILCIVVIQPEIPVKQLKNLNTVPSSKLLYHRLDLLGQPSACLH
FKQLATLESPTIMLSAGSFSSPYEHLSQPETKRMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQMEMSSLNTYIVRRYI
ATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVGGAGYVVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFYKVLMD
LLPVCNQDGGNKIRCFIMEDRGYLVAHPTLIDPKGHAPVEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQRFYKFNTSLAGDLT
NLVHGSHCSKYRLARIPGTNAFVGIVNETCDSLAFCACSMVDRLCLNCHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEVHQEPV
TYTAIDPGLQDALHQCVNSRCSQRLESGDCFGVLDCEWCMVDSDGKTHLDKPYCAPQKECFGGIVGAKSPYVDDMGAIGDEVITLNMIKS
APVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQEMSVRMSNLENDRDERDDDSHEDRGIISNTRFIAAVIERHAHSPERRR
RYWGRSGTESDHGYSTMSPQEDSENPPCNNDPLSAGVDVGNHDEDLDLDTPPQTAALLSHKFHHYRSHHPTLHHSHHLQAAVTVHTVDAE

--------------------------------------------------------------
>In-frame_ENST00000437198_ENST00000290039_TCGA-4W-AA9S-01A_PARN_chr16_14687158_-_CACHD1_chr1_65016277_length(transcript)=6184nt_BP=1060nt
GCGCGCTGTTTCCGGAAGTCGCGGCCGGCGTCACCGCTGCGGCTGCCTCAGCTACTGCCGCAGTCGCCGCGGAATTCGGCGAGTAGAACC
GCTGAGGCGGGCGCGGGCCCGGGTGGGGCCAAGGTTCCGGCCACTCTGCAGAATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCA
CAAAGTGTACCAGGCCATAGAGGAGGCCGACTTCTTCGCCATCGATGGGGAGTTTTCAGGAATCAGTGATGGACCTTCAGTCTCTGCATT
AACAAATGGTTTTGACACTCCAGAAGAGAGGTATCAGAAGCTTAAAAAGCATTCCATGGACTTTTTGCTATTTCAGTTTGGCCTTTGCAC
TTTTAAGTATGACTACACAGATTCAAAGTATATAACGAAGTCATTTAACTTCTATGTTTTCCCGAAACCCTTCAATAGATCCTCACCAGA
TGTCAAATTTGTTTGTCAGAGCTCCAGCATTGACTTTCTAGCAAGCCAGGGATTTGATTTTAATAAAGTTTTTCGAAATGGAATTCCATA
TTTAAATCAGGAAGAAGAAAGACAGTTAAGAGAGCAGTATGATGAAAAACGTTCACAGGCGAATGGTGCAGGAGCTCTGTCCTATGTATC
TCCTAACACTTCAAAATGTCCTGTCACGATTCCTGAGGATCAAAAGAAGTTTATTGACCAAGTGGTAGAGAAAATAGAGGATTTATTACA
AAGTGAAGAAAACAAGAACTTGGATTTAGAGCCATGTACCGGGTTCCAAAGAAAACTAATTTATCAGACTTTGAGCTGGAAGTATCCGAA
AGGCATTCATGTTGAGACTTTAGAAACTGAAAAGAAGGAGCGATATATAGTTATCAGCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGA
GCAGCAGAAACATGCCAAAGAACAGGAGGAGCTGAATGATGCTGTGGGATTTTCTAGAGTCATTCACGCCATTGCTAATTCGGGAAAACT
TGTTATTGGACACAATATGCTCTTGGACGTCATGCACACAGTTCATCAGTTCTACTGCCCTCTGCCTGCGCGGATATTCAACTCCTTTGT
TTACACTGAGAAAATCTCAAATGGAGAAAGTGAAGTACAGCAGCTAGCCAAAAAAATCCGAGAGAAGTTCAACCGTTACTTGGATGTGGT
CAATCGGAACAAGCAAGTTGTAGAAGCATCCTATACGGCTCACCTAACCTCTCCCCTAACTGCAATTCAAGACTGCTGTACTATCCCACC
TTCCATGATGGAATTCGATGGGAACTTTAATACCAATGTGTCTAGAACAATTAGTTGTGATCGACTTTCTACTACTGTTAATAGCCGGGC
CTTCAATCCAGGACGAGACTTAAATTCAGTTCTTGCAGACAACCTGAAATCCAACCCTGGAATTAAGTGGCAATATTTCAGTTCAGAAGA
AGGAATTTTCACTGTTTTCCCAGCACACAAGTTCCGGTGTAAGGGCAGCTACGAACACCGCAGTAGACCCATCTACGTCTCTACAGTCCG
GCCGCAGTCAAAGCACATAGTAGTGATTCTGGACCACGGGGCTTCAGTCACAGACACTCAGCTTCAGATTGCCAAGGACGCTGCTCAGGT
CATCCTCAGCGCCATCGATGAACATGACAAGATTTCTGTGTTAACTGTGGCAGATACCGTCCGGACTTGCTCACTAGACCAGTGCTATAA
GACCTTCTTGTCTCCAGCCACCAGTGAGACAAAAAGGAAAATGTCCACCTTTGTTAGCAGCGTGAAGTCTTCAGACAGTCCTACCCAGCA
CGCAGTGGGATTCCAAAAGGCATTTCAGCTGATTCGAAGTACAAACAATAACACAAAGTTCCAAGCAAATACAGACATGGTCATCATTTA
CCTGTCAGCTGGCATTACATCAAAGGACTCTTCGGAAGAAGATAAAAAAGCGACTCTCCAAGTCATCAATGAAGAAAATAGCTTTCTAAA
CAACTCTGTAATGATTCTCACCTATGCCCTCATGAACGATGGGGTGACTGGTTTGAAAGAGCTGGCTTTTCTGAGGGATCTAGCTGAACA
GAATTCAGGGAAGTACGGTGTGCCAGACCGGATGGCCTTGCCTGTGATTAAGGGCAGCATGATGGTGCTGAATCAGTTGAGCAACCTGGA
GACCACAGTGGGCAGGTTCTACACAAACCTTCCCAACCGGATGATTGATGAAGCCGTCTTCAGCCTGCCCTTCTCTGATGAGATGGGAGA
TGGTTTGATAATGACTGTGAGTAAACCCTGTTATTTTGGAAACCTACTTCTGGGAATTGTAGGTGTGGACGTGAATCTGGCTTACATTCT
TGAAGACGTGACGTATTACCAAGACTCTTTGGCTTCCTATACTTTTCTCATAGACGACAAAGGATATACACTTATGCACCCATCTCTTAC
CAGGCCATATTTATTGTCAGAGCCCCCACTTCATACTGACATCATACATTATGAAAATATTCCAAAATTTGAATTAGTTCGGCAAAATAT
CCTAAGCCTCCCTCTGGGCAGCCAGATTATCGCAGTCCCTGTGAACTCATCCCTGTCTTGGCACATAAACAAGCTGAGAGAAACTGGAAA
GGAAGCCTACAATGTTAGCTATGCCTGGAAGATGGTACAAGACACTTCCTTTATTCTGTGTATTGTGGTGATACAACCAGAAATACCTGT
GAAACAACTGAAGAACCTCAACACTGTTCCCAGCAGCAAGCTGCTGTACCACCGGCTGGATCTCCTTGGCCAGCCCAGTGCTTGCCTCCA
CTTCAAACAGCTGGCAACCCTAGAAAGTCCCACCATCATGCTGTCTGCTGGCAGCTTTTCCTCCCCCTATGAGCACCTCAGCCAGCCAGA
GACAAAGCGCATGGTAGAGCACTACACCGCCTATCTCAGCGACAACACCCGCCTCATTGCTAACCCGGGCCTCAAATTCTCTGTCAGAAA
TGAAGTAATGGCTACCAGCCACGTCACAGATGAATGGATGACACAAATGGAAATGAGTAGCCTGAACACTTACATTGTCCGCCGTTACAT
AGCAACACCCAATGGCGTCCTCAGAATTTATCCTGGTTCCCTCATGGACAAAGCATTTGATCCCACTAGGAGACAATGGTATCTCCATGC
AGTAGCTAATCCAGGGTTGATTTCTTTGACTGGTCCTTACTTAGATGTTGGAGGAGCTGGTTATGTTGTGACAATCAGTCACACAATTCA
TTCATCCAGTACACAGCTGTCTTCTGGGCACACTGTGGCTGTGATGGGCATTGACTTCACACTCAGATACTTCTACAAAGTTCTGATGGA
CCTATTACCTGTCTGTAACCAAGATGGTGGCAACAAAATAAGGTGCTTCATAATGGAGGACAGGGGTTATCTGGTGGCGCACCCGACTCT
CATCGACCCCAAAGGACATGCACCTGTGGAGCAGCAGCACATCACCCACAAGGAGCCCCTGGTAGCAAATGATATCCTCAACCACCCCAA
CTTTGTAAAGAAAAACCTGTGCAACAGCTTCAGTGACAGAACGGTCCAGAGGTTTTATAAATTCAACACCAGCCTTGCGGGGGATTTGAC
GAACCTTGTGCATGGCAGCCACTGTTCCAAATACAGATTAGCAAGGATCCCAGGAACCAACGCGTTTGTTGGCATTGTCAACGAAACCTG
CGACTCTCTTGCCTTCTGTGCCTGCAGCATGGTGGACCGACTCTGTCTCAACTGTCACCGAATGGAACAAAATGAATGTGAATGTCCTTG
TGAGTGCCCTCTAGAGGTCAATGAGTGCACTGGCAACCTCACCAATGCAGAGAACCGAAACCCCAGCTGCGAGGTCCACCAGGAGCCGGT
GACATACACAGCTATTGACCCTGGCCTGCAAGATGCTCTTCACCAGTGTGTCAACAGCAGGTGCAGTCAGAGGCTGGAAAGTGGGGACTG
TTTTGGGGTGCTGGATTGTGAATGGTGCATGGTGGACAGTGATGGAAAGACTCACCTGGACAAACCCTACTGTGCCCCCCAGAAAGAATG
CTTCGGGGGGATTGTGGGAGCCAAAAGTCCCTACGTTGATGACATGGGAGCAATAGGTGATGAGGTGATCACATTAAACATGATTAAAAG
CGCCCCTGTGGGTCCTGTGGCTGGAGGGATCATGGGATGCATCATGGTCTTGGTCCTGGCGGTGTATGCCTACCGCCACCAGATTCATCG
CCGGAGCCATCAGCATATGTCTCCTCTTGCTGCCCAAGAAATGTCAGTGCGTATGTCCAACCTGGAGAATGACAGAGATGAAAGGGACGA
CGACAGCCACGAAGACAGAGGCATCATCAGCAACACTCGGTTTATAGCTGCGGTCATCGAACGACATGCACACAGTCCAGAAAGAAGGCG
CCGCTACTGGGGTCGATCAGGAACAGAAAGTGATCATGGTTACAGCACCATGAGCCCACAGGAGGACAGTGAAAATCCTCCATGCAACAA
TGACCCCTTGTCAGCCGGGGTCGATGTGGGAAACCATGATGAGGACTTAGACCTGGATACCCCCCCTCAGACTGCTGCCCTACTAAGTCA
CAAGTTCCACCACTACCGGTCACACCACCCTACACTTCATCATAGCCACCACTTACAGGCGGCCGTCACGGTACACACTGTCGATGCAGA
ATGCTAACAATCTCCTCACCTCCACGCCAAGATGAGATCTGGGAGCTACAGAATGTTCTGGAAAGAAAAAGAACCGGCTTAAAACCCACA
GCAAGAGACCTCCCTTGTGTTTGTGCTTTGTGCAGAGTTGTTTGAGTCATTTCCTGCCTGTCGACATGGTTAAAAACGAGAGAAACAACA
ACACAGTCACATTTGTGAAGATGTGAGGCTGGTTCTGAAATGGAGGGGAAATAAGCCTGATGAACAGACCTGCCATAACACTAATGGAAG
GTAACAGAAGGCGAACCTCCAAACACAGAGACGGAACCTGCAAGTGAAGCTGAGCCAGAGGAATGTTCCAAAGAGCCAGAAGCATTCAGC
TCTCCTTAACTGGAAGAGAGAAAAATCTGCTCACCCAGAGACTGGAATGTGGCACATGCAGATACAAATGTGTGCATTGAAGATTTCGCT
TTGTTTCTTAGCGGTACCTGGATACCACAGTTGCTGTATGGAACTCATGTTATGCTCTAAACGATGCATCTCAGAATTTCTAAGTAAAGG
ATTATTTTTCTACTATTTATTGAACTTTCAAACATTCTCAAACTTTGGGGAAAAGGAAAGGAAACACAGGAGAAGTTTTCAGCAGTTGCC
CCGAGCTGTTTTGTGTGTAATGAAGTGGTTCTTTGATTAAGGAGCTCTATTTCTTATTTAACTGATATCCCACTGCCCCACTCCACAAAA
TAGGAAAATGAAGAAATCTTTCTCTCTGACTTGTTTACATCATTTCACGGAAACACATCTTTGTTTGTAATGCAGTATTCTTTCTCTGTG
TTTGACAGAGATGGGGAGGGGCAGAGGAATTTAAGAGGTTTTAAAAGAAATGTTATGTTTCTTATGACTTGTTTCCACTCCTCGTACAAT
GCTATTCTTAGGTTTCTACGAAACCTAATGTTAGAACCGCATCCTTTCAGCTAAGGGAGGGTTGGATTTATTTTCCTTGTTTTAGAGACT
ACAAATTTTTAAATATCCCATTTTGACTGAGAATATTGACATATAAGGGAAGAAGTTTTCTAAATTGTGAAAGTCTGGTTCTTAATTAAA
GAATTTTTTTTTTAATATCACGGTTAAAAGCTGCTGCCAGTTAGCCAAGACATTATCCACCAAATTGCTTTGTGATTTATACAGGGATTA
ATCAAATCTGGCTACTATAACATGGGGCATTGTAACTTTAAAGTAGTGTTTTAATTACAGTGATGTATTTTAGACTCACATTTTGTGATT
CAAATATGTTATAAAGGCATTCTTGCACCATGGTAAAGAATGTGTGTGGTAAATCTCCGTTTATATGTAGTTGGAAAAAATTCACTGAAT
AATGTTTTAATGATAGGGTATTATGATACAATGTAAAAAACAATTGGTTCTTCAGCAGTACAGAAAGTAAACTATATATGTGCTATCAGG

>In-frame_ENST00000437198_ENST00000290039_TCGA-4W-AA9S-01A_PARN_chr16_14687158_-_CACHD1_chr1_65016277_length(amino acids)=1531AA_start in transcript=91_stop in transcript=4686
MRRARARVGPRFRPLCRMEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCT
FKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVS
PNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRRE
QQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPARIFNSFVYTEKISNGESEVQQLAKKIREKFNRYLDVV
NRNKQVVEASYTAHLTSPLTAIQDCCTIPPSMMEFDGNFNTNVSRTISCDRLSTTVNSRAFNPGRDLNSVLADNLKSNPGIKWQYFSSEE
GIFTVFPAHKFRCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASVTDTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQCYK
TFLSPATSETKRKMSTFVSSVKSSDSPTQHAVGFQKAFQLIRSTNNNTKFQANTDMVIIYLSAGITSKDSSEEDKKATLQVINEENSFLN
NSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKYGVPDRMALPVIKGSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFSDEMGD
GLIMTVSKPCYFGNLLLGIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFELVRQNI
LSLPLGSQIIAVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTSFILCIVVIQPEIPVKQLKNLNTVPSSKLLYHRLDLLGQPSACLH
FKQLATLESPTIMLSAGSFSSPYEHLSQPETKRMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQMEMSSLNTYIVRRYI
ATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVGGAGYVVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFYKVLMD
LLPVCNQDGGNKIRCFIMEDRGYLVAHPTLIDPKGHAPVEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQRFYKFNTSLAGDLT
NLVHGSHCSKYRLARIPGTNAFVGIVNETCDSLAFCACSMVDRLCLNCHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEVHQEPV
TYTAIDPGLQDALHQCVNSRCSQRLESGDCFGVLDCEWCMVDSDGKTHLDKPYCAPQKECFGGIVGAKSPYVDDMGAIGDEVITLNMIKS
APVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQEMSVRMSNLENDRDERDDDSHEDRGIISNTRFIAAVIERHAHSPERRR
RYWGRSGTESDHGYSTMSPQEDSENPPCNNDPLSAGVDVGNHDEDLDLDTPPQTAALLSHKFHHYRSHHPTLHHSHHLQAAVTVHTVDAE

--------------------------------------------------------------
>In-frame_ENST00000420015_ENST00000371073_TCGA-4W-AA9S-01A_PARN_chr16_14687158_-_CACHD1_chr1_65016277_length(transcript)=6038nt_BP=914nt
TTTCCGGAAGTCGCGGCCGGCGTCACCGCTGCGGCTGCCTCAGCTACTGCCGCAGTCGCCGCGGAATTCGGCGAGTAGAACCGCTGAGGC
GGGCGCGGGCCCGGGTGGGGCCAAGGTTCCGGCCACTCTGCAGAATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCACAAAGTGT
ACCAGGCCATAGAGGAGGCCGACTTCTTCGCCATCGATGGGGAGTTTTCAGGAATCAGTGATGGACCTTCAGTCTCTGCATTAACAAATG
GTTTTGACACTCCAGAAGAGAGATCCTCACCAGATGTCAAATTTGTTTGTCAGAGCTCCAGCATTGACTTTCTAGCAAGCCAGGGATTTG
ATTTTAATAAAGTTTTTCGAAATGGAATTCCATATTTAAATCAGGAAGAAGAAAGACAGTTAAGAGAGCAGTATGATGAAAAACGTTCAC
AGGCGAATGGTGCAGGAGCTCTGTCCTATGTATCTCCTAACACTTCAAAATGTCCTGTCACGATTCCTGAGGATCAAAAGAAGTTTATTG
ACCAAGTGGTAGAGAAAATAGAGGATTTATTACAAAGTGAAGAAAACAAGAACTTGGATTTAGAGCCATGTACCGGGTTCCAAAGAAAAC
TAATTTATCAGACTTTGAGCTGGAAGTATCCGAAAGGCATTCATGTTGAGACTTTAGAAACTGAAAAGAAGGAGCGATATATAGTTATCA
GCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGAGCAGCAGAAACATGCCAAAGAACAGGAGGAGCTGAATGATGCTGTGGGATTTTCTA
GAGTCATTCACGCCATTGCTAATTCGGGAAAACTTGTTATTGGACACAATATGCTCTTGGACGTCATGCACACAGTTCATCAGTTCTACT
GCCCTCTGCCTGCGCGGATATTCAACTCCTTTGTTTACACTGAGAAAATCTCAAATGGAGAAAGTGAAGTACAGCAGCTAGCCAAAAAAA
TCCGAGAGAAGTTCAACCGTTACTTGGATGTGGTCAATCGGAACAAGCAAGTTGTAGAAGCATCCTATACGGCTCACCTAACCTCTCCCC
TAACTGCAATTCAAGACTGCTGTACTATCCCACCTTCCATGATGGAATTCGATGGGAACTTTAATACCAATGTGTCTAGAACAATTAGTT
GTGATCGACTTTCTACTACTGTTAATAGCCGGGCCTTCAATCCAGGACGAGACTTAAATTCAGTTCTTGCAGACAACCTGAAATCCAACC
CTGGAATTAAGTGGCAATATTTCAGTTCAGAAGAAGGAATTTTCACTGTTTTCCCAGCACACAAGTTCCGGTGTAAGGGCAGCTACGAAC
ACCGCAGTAGACCCATCTACGTCTCTACAGTCCGGCCGCAGTCAAAGCACATAGTAGTGATTCTGGACCACGGGGCTTCAGTCACAGACA
CTCAGCTTCAGATTGCCAAGGACGCTGCTCAGGTCATCCTCAGCGCCATCGATGAACATGACAAGATTTCTGTGTTAACTGTGGCAGATA
CCGTCCGGACTTGCTCACTAGACCAGTGCTATAAGACCTTCTTGTCTCCAGCCACCAGTGAGACAAAAAGGAAAATGTCCACCTTTGTTA
GCAGCGTGAAGTCTTCAGACAGTCCTACCCAGCACGCAGTGGGATTCCAAAAGGCATTTCAGCTGATTCGAAGTACAAACAATAACACAA
AGTTCCAAGCAAATACAGACATGGTCATCATTTACCTGTCAGCTGGCATTACATCAAAGGACTCTTCGGAAGAAGATAAAAAAGCGACTC
TCCAAGTCATCAATGAAGAAAATAGCTTTCTAAACAACTCTGTAATGATTCTCACCTATGCCCTCATGAACGATGGGGTGACTGGTTTGA
AAGAGCTGGCTTTTCTGAGGGATCTAGCTGAACAGAATTCAGGGAAGTACGGTGTGCCAGACCGGATGGCCTTGCCTGTGATTAAGGGCA
GCATGATGGTGCTGAATCAGTTGAGCAACCTGGAGACCACAGTGGGCAGGTTCTACACAAACCTTCCCAACCGGATGATTGATGAAGCCG
TCTTCAGCCTGCCCTTCTCTGATGAGATGGGAGATGGTTTGATAATGACTGTGAGTAAACCCTGTTATTTTGGAAACCTACTTCTGGGAA
TTGTAGGTGTGGACGTGAATCTGGCTTACATTCTTGAAGACGTGACGTATTACCAAGACTCTTTGGCTTCCTATACTTTTCTCATAGACG
ACAAAGGATATACACTTATGCACCCATCTCTTACCAGGCCATATTTATTGTCAGAGCCCCCACTTCATACTGACATCATACATTATGAAA
ATATTCCAAAATTTGAATTAGTTCGGCAAAATATCCTAAGCCTCCCTCTGGGCAGCCAGATTATCGCAGTCCCTGTGAACTCATCCCTGT
CTTGGCACATAAACAAGCTGAGAGAAACTGGAAAGGAAGCCTACAATGTTAGCTATGCCTGGAAGATGGTACAAGACACTTCCTTTATTC
TGTGTATTGTGGTGATACAACCAGAAATACCTGTGAAACAACTGAAGAACCTCAACACTGTTCCCAGCAGCAAGCTGCTGTACCACCGGC
TGGATCTCCTTGGCCAGCCCAGTGCTTGCCTCCACTTCAAACAGCTGGCAACCCTAGAAAGTCCCACCATCATGCTGTCTGCTGGCAGCT
TTTCCTCCCCCTATGAGCACCTCAGCCAGCCAGAGACAAAGCGCATGGTAGAGCACTACACCGCCTATCTCAGCGACAACACCCGCCTCA
TTGCTAACCCGGGCCTCAAATTCTCTGTCAGAAATGAAGTAATGGCTACCAGCCACGTCACAGATGAATGGATGACACAAATGGAAATGA
GTAGCCTGAACACTTACATTGTCCGCCGTTACATAGCAACACCCAATGGCGTCCTCAGAATTTATCCTGGTTCCCTCATGGACAAAGCAT
TTGATCCCACTAGGAGACAATGGTATCTCCATGCAGTAGCTAATCCAGGGTTGATTTCTTTGACTGGTCCTTACTTAGATGTTGGAGGAG
CTGGTTATGTTGTGACAATCAGTCACACAATTCATTCATCCAGTACACAGCTGTCTTCTGGGCACACTGTGGCTGTGATGGGCATTGACT
TCACACTCAGATACTTCTACAAAGTTCTGATGGACCTATTACCTGTCTGTAACCAAGATGGTGGCAACAAAATAAGGTGCTTCATAATGG
AGGACAGGGGTTATCTGGTGGCGCACCCGACTCTCATCGACCCCAAAGGACATGCACCTGTGGAGCAGCAGCACATCACCCACAAGGAGC
CCCTGGTAGCAAATGATATCCTCAACCACCCCAACTTTGTAAAGAAAAACCTGTGCAACAGCTTCAGTGACAGAACGGTCCAGAGGTTTT
ATAAATTCAACACCAGCCTTGCGGGGGATTTGACGAACCTTGTGCATGGCAGCCACTGTTCCAAATACAGATTAGCAAGGATCCCAGGAA
CCAACGCGTTTGTTGGCATTGTCAACGAAACCTGCGACTCTCTTGCCTTCTGTGCCTGCAGCATGGTGGACCGACTCTGTCTCAACTGTC
ACCGAATGGAACAAAATGAATGTGAATGTCCTTGTGAGTGCCCTCTAGAGGTCAATGAGTGCACTGGCAACCTCACCAATGCAGAGAACC
GAAACCCCAGCTGCGAGGTCCACCAGGAGCCGGTGACATACACAGCTATTGACCCTGGCCTGCAAGATGCTCTTCACCAGTGTGTCAACA
GCAGGTGCAGTCAGAGGCTGGAAAGTGGGGACTGTTTTGGGGTGCTGGATTGTGAATGGTGCATGGTGGACAGTGATGGAAAGACTCACC
TGGACAAACCCTACTGTGCCCCCCAGAAAGAATGCTTCGGGGGGATTGTGGGAGCCAAAAGTCCCTACGTTGATGACATGGGAGCAATAG
GTGATGAGGTGATCACATTAAACATGATTAAAAGCGCCCCTGTGGGTCCTGTGGCTGGAGGGATCATGGGATGCATCATGGTCTTGGTCC
TGGCGGTGTATGCCTACCGCCACCAGATTCATCGCCGGAGCCATCAGCATATGTCTCCTCTTGCTGCCCAAGAAATGTCAGTGCGTATGT
CCAACCTGGAGAATGACAGAGATGAAAGGGACGACGACAGCCACGAAGACAGAGGCATCATCAGCAACACTCGGTTTATAGCTGCGGTCA
TCGAACGACATGCACACAGTCCAGAAAGAAGGCGCCGCTACTGGGGTCGATCAGGAACAGAAAGTGATCATGGTTACAGCACCATGAGCC
CACAGGAGGACAGTGAAAATCCTCCATGCAACAATGACCCCTTGTCAGCCGGGGTCGATGTGGGAAACCATGATGAGGACTTAGACCTGG
ATACCCCCCCTCAGACTGCTGCCCTACTAAGTCACAAGTTCCACCACTACCGGTCACACCACCCTACACTTCATCATAGCCACCACTTAC
AGGCGGCCGTCACGGTACACACTGTCGATGCAGAATGCTAACAATCTCCTCACCTCCACGCCAAGATGAGATCTGGGAGCTACAGAATGT
TCTGGAAAGAAAAAGAACCGGCTTAAAACCCACAGCAAGAGACCTCCCTTGTGTTTGTGCTTTGTGCAGAGTTGTTTGAGTCATTTCCTG
CCTGTCGACATGGTTAAAAACGAGAGAAACAACAACACAGTCACATTTGTGAAGATGTGAGGCTGGTTCTGAAATGGAGGGGAAATAAGC
CTGATGAACAGACCTGCCATAACACTAATGGAAGGTAACAGAAGGCGAACCTCCAAACACAGAGACGGAACCTGCAAGTGAAGCTGAGCC
AGAGGAATGTTCCAAAGAGCCAGAAGCATTCAGCTCTCCTTAACTGGAAGAGAGAAAAATCTGCTCACCCAGAGACTGGAATGTGGCACA
TGCAGATACAAATGTGTGCATTGAAGATTTCGCTTTGTTTCTTAGCGGTACCTGGATACCACAGTTGCTGTATGGAACTCATGTTATGCT
CTAAACGATGCATCTCAGAATTTCTAAGTAAAGGATTATTTTTCTACTATTTATTGAACTTTCAAACATTCTCAAACTTTGGGGAAAAGG
AAAGGAAACACAGGAGAAGTTTTCAGCAGTTGCCCCGAGCTGTTTTGTGTGTAATGAAGTGGTTCTTTGATTAAGGAGCTCTATTTCTTA
TTTAACTGATATCCCACTGCCCCACTCCACAAAATAGGAAAATGAAGAAATCTTTCTCTCTGACTTGTTTACATCATTTCACGGAAACAC
ATCTTTGTTTGTAATGCAGTATTCTTTCTCTGTGTTTGACAGAGATGGGGAGGGGCAGAGGAATTTAAGAGGTTTTAAAAGAAATGTTAT
GTTTCTTATGACTTGTTTCCACTCCTCGTACAATGCTATTCTTAGGTTTCTACGAAACCTAATGTTAGAACCGCATCCTTTCAGCTAAGG
GAGGGTTGGATTTATTTTCCTTGTTTTAGAGACTACAAATTTTTAAATATCCCATTTTGACTGAGAATATTGACATATAAGGGAAGAAGT
TTTCTAAATTGTGAAAGTCTGGTTCTTAATTAAAGAATTTTTTTTTTAATATCACGGTTAAAAGCTGCTGCCAGTTAGCCAAGACATTAT
CCACCAAATTGCTTTGTGATTTATACAGGGATTAATCAAATCTGGCTACTATAACATGGGGCATTGTAACTTTAAAGTAGTGTTTTAATT
ACAGTGATGTATTTTAGACTCACATTTTGTGATTCAAATATGTTATAAAGGCATTCTTGCACCATGGTAAAGAATGTGTGTGGTAAATCT
CCGTTTATATGTAGTTGGAAAAAATTCACTGAATAATGTTTTAATGATAGGGTATTATGATACAATGTAAAAAACAATTGGTTCTTCAGC
AGTACAGAAAGTAAACTATATATGTGCTATCAGGAAACCCCTTCATACTGTGTATAAAATTGCAATCTAGTGAAATAAACCGTATGCAAT

>In-frame_ENST00000420015_ENST00000371073_TCGA-4W-AA9S-01A_PARN_chr16_14687158_-_CACHD1_chr1_65016277_length(amino acids)=1485AA_start in transcript=83_stop in transcript=4540
MRRARARVGPRFRPLCRMEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERSSPDVKFVCQSSSIDFLASQ
GFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQ
RKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQ
FYCPLPARIFNSFVYTEKISNGESEVQQLAKKIREKFNRYLDVVNRNKQVVEASYTAHLTSPLTAIQDCCTIPPSMMEFDGNFNTNVSRT
ISCDRLSTTVNSRAFNPGRDLNSVLADNLKSNPGIKWQYFSSEEGIFTVFPAHKFRCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASV
TDTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQCYKTFLSPATSETKRKMSTFVSSVKSSDSPTQHAVGFQKAFQLIRSTNN
NTKFQANTDMVIIYLSAGITSKDSSEEDKKATLQVINEENSFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKYGVPDRMALPVI
KGSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFSDEMGDGLIMTVSKPCYFGNLLLGIVGVDVNLAYILEDVTYYQDSLASYTFL
IDDKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFELVRQNILSLPLGSQIIAVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTS
FILCIVVIQPEIPVKQLKNLNTVPSSKLLYHRLDLLGQPSACLHFKQLATLESPTIMLSAGSFSSPYEHLSQPETKRMVEHYTAYLSDNT
RLIANPGLKFSVRNEVMATSHVTDEWMTQMEMSSLNTYIVRRYIATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDV
GGAGYVVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRCFIMEDRGYLVAHPTLIDPKGHAPVEQQHITH
KEPLVANDILNHPNFVKKNLCNSFSDRTVQRFYKFNTSLAGDLTNLVHGSHCSKYRLARIPGTNAFVGIVNETCDSLAFCACSMVDRLCL
NCHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEVHQEPVTYTAIDPGLQDALHQCVNSRCSQRLESGDCFGVLDCEWCMVDSDGK
THLDKPYCAPQKECFGGIVGAKSPYVDDMGAIGDEVITLNMIKSAPVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQEMSV
RMSNLENDRDERDDDSHEDRGIISNTRFIAAVIERHAHSPERRRRYWGRSGTESDHGYSTMSPQEDSENPPCNNDPLSAGVDVGNHDEDL

--------------------------------------------------------------
>In-frame_ENST00000420015_ENST00000290039_TCGA-4W-AA9S-01A_PARN_chr16_14687158_-_CACHD1_chr1_65016277_length(transcript)=6038nt_BP=914nt
TTTCCGGAAGTCGCGGCCGGCGTCACCGCTGCGGCTGCCTCAGCTACTGCCGCAGTCGCCGCGGAATTCGGCGAGTAGAACCGCTGAGGC
GGGCGCGGGCCCGGGTGGGGCCAAGGTTCCGGCCACTCTGCAGAATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCACAAAGTGT
ACCAGGCCATAGAGGAGGCCGACTTCTTCGCCATCGATGGGGAGTTTTCAGGAATCAGTGATGGACCTTCAGTCTCTGCATTAACAAATG
GTTTTGACACTCCAGAAGAGAGATCCTCACCAGATGTCAAATTTGTTTGTCAGAGCTCCAGCATTGACTTTCTAGCAAGCCAGGGATTTG
ATTTTAATAAAGTTTTTCGAAATGGAATTCCATATTTAAATCAGGAAGAAGAAAGACAGTTAAGAGAGCAGTATGATGAAAAACGTTCAC
AGGCGAATGGTGCAGGAGCTCTGTCCTATGTATCTCCTAACACTTCAAAATGTCCTGTCACGATTCCTGAGGATCAAAAGAAGTTTATTG
ACCAAGTGGTAGAGAAAATAGAGGATTTATTACAAAGTGAAGAAAACAAGAACTTGGATTTAGAGCCATGTACCGGGTTCCAAAGAAAAC
TAATTTATCAGACTTTGAGCTGGAAGTATCCGAAAGGCATTCATGTTGAGACTTTAGAAACTGAAAAGAAGGAGCGATATATAGTTATCA
GCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGAGCAGCAGAAACATGCCAAAGAACAGGAGGAGCTGAATGATGCTGTGGGATTTTCTA
GAGTCATTCACGCCATTGCTAATTCGGGAAAACTTGTTATTGGACACAATATGCTCTTGGACGTCATGCACACAGTTCATCAGTTCTACT
GCCCTCTGCCTGCGCGGATATTCAACTCCTTTGTTTACACTGAGAAAATCTCAAATGGAGAAAGTGAAGTACAGCAGCTAGCCAAAAAAA
TCCGAGAGAAGTTCAACCGTTACTTGGATGTGGTCAATCGGAACAAGCAAGTTGTAGAAGCATCCTATACGGCTCACCTAACCTCTCCCC
TAACTGCAATTCAAGACTGCTGTACTATCCCACCTTCCATGATGGAATTCGATGGGAACTTTAATACCAATGTGTCTAGAACAATTAGTT
GTGATCGACTTTCTACTACTGTTAATAGCCGGGCCTTCAATCCAGGACGAGACTTAAATTCAGTTCTTGCAGACAACCTGAAATCCAACC
CTGGAATTAAGTGGCAATATTTCAGTTCAGAAGAAGGAATTTTCACTGTTTTCCCAGCACACAAGTTCCGGTGTAAGGGCAGCTACGAAC
ACCGCAGTAGACCCATCTACGTCTCTACAGTCCGGCCGCAGTCAAAGCACATAGTAGTGATTCTGGACCACGGGGCTTCAGTCACAGACA
CTCAGCTTCAGATTGCCAAGGACGCTGCTCAGGTCATCCTCAGCGCCATCGATGAACATGACAAGATTTCTGTGTTAACTGTGGCAGATA
CCGTCCGGACTTGCTCACTAGACCAGTGCTATAAGACCTTCTTGTCTCCAGCCACCAGTGAGACAAAAAGGAAAATGTCCACCTTTGTTA
GCAGCGTGAAGTCTTCAGACAGTCCTACCCAGCACGCAGTGGGATTCCAAAAGGCATTTCAGCTGATTCGAAGTACAAACAATAACACAA
AGTTCCAAGCAAATACAGACATGGTCATCATTTACCTGTCAGCTGGCATTACATCAAAGGACTCTTCGGAAGAAGATAAAAAAGCGACTC
TCCAAGTCATCAATGAAGAAAATAGCTTTCTAAACAACTCTGTAATGATTCTCACCTATGCCCTCATGAACGATGGGGTGACTGGTTTGA
AAGAGCTGGCTTTTCTGAGGGATCTAGCTGAACAGAATTCAGGGAAGTACGGTGTGCCAGACCGGATGGCCTTGCCTGTGATTAAGGGCA
GCATGATGGTGCTGAATCAGTTGAGCAACCTGGAGACCACAGTGGGCAGGTTCTACACAAACCTTCCCAACCGGATGATTGATGAAGCCG
TCTTCAGCCTGCCCTTCTCTGATGAGATGGGAGATGGTTTGATAATGACTGTGAGTAAACCCTGTTATTTTGGAAACCTACTTCTGGGAA
TTGTAGGTGTGGACGTGAATCTGGCTTACATTCTTGAAGACGTGACGTATTACCAAGACTCTTTGGCTTCCTATACTTTTCTCATAGACG
ACAAAGGATATACACTTATGCACCCATCTCTTACCAGGCCATATTTATTGTCAGAGCCCCCACTTCATACTGACATCATACATTATGAAA
ATATTCCAAAATTTGAATTAGTTCGGCAAAATATCCTAAGCCTCCCTCTGGGCAGCCAGATTATCGCAGTCCCTGTGAACTCATCCCTGT
CTTGGCACATAAACAAGCTGAGAGAAACTGGAAAGGAAGCCTACAATGTTAGCTATGCCTGGAAGATGGTACAAGACACTTCCTTTATTC
TGTGTATTGTGGTGATACAACCAGAAATACCTGTGAAACAACTGAAGAACCTCAACACTGTTCCCAGCAGCAAGCTGCTGTACCACCGGC
TGGATCTCCTTGGCCAGCCCAGTGCTTGCCTCCACTTCAAACAGCTGGCAACCCTAGAAAGTCCCACCATCATGCTGTCTGCTGGCAGCT
TTTCCTCCCCCTATGAGCACCTCAGCCAGCCAGAGACAAAGCGCATGGTAGAGCACTACACCGCCTATCTCAGCGACAACACCCGCCTCA
TTGCTAACCCGGGCCTCAAATTCTCTGTCAGAAATGAAGTAATGGCTACCAGCCACGTCACAGATGAATGGATGACACAAATGGAAATGA
GTAGCCTGAACACTTACATTGTCCGCCGTTACATAGCAACACCCAATGGCGTCCTCAGAATTTATCCTGGTTCCCTCATGGACAAAGCAT
TTGATCCCACTAGGAGACAATGGTATCTCCATGCAGTAGCTAATCCAGGGTTGATTTCTTTGACTGGTCCTTACTTAGATGTTGGAGGAG
CTGGTTATGTTGTGACAATCAGTCACACAATTCATTCATCCAGTACACAGCTGTCTTCTGGGCACACTGTGGCTGTGATGGGCATTGACT
TCACACTCAGATACTTCTACAAAGTTCTGATGGACCTATTACCTGTCTGTAACCAAGATGGTGGCAACAAAATAAGGTGCTTCATAATGG
AGGACAGGGGTTATCTGGTGGCGCACCCGACTCTCATCGACCCCAAAGGACATGCACCTGTGGAGCAGCAGCACATCACCCACAAGGAGC
CCCTGGTAGCAAATGATATCCTCAACCACCCCAACTTTGTAAAGAAAAACCTGTGCAACAGCTTCAGTGACAGAACGGTCCAGAGGTTTT
ATAAATTCAACACCAGCCTTGCGGGGGATTTGACGAACCTTGTGCATGGCAGCCACTGTTCCAAATACAGATTAGCAAGGATCCCAGGAA
CCAACGCGTTTGTTGGCATTGTCAACGAAACCTGCGACTCTCTTGCCTTCTGTGCCTGCAGCATGGTGGACCGACTCTGTCTCAACTGTC
ACCGAATGGAACAAAATGAATGTGAATGTCCTTGTGAGTGCCCTCTAGAGGTCAATGAGTGCACTGGCAACCTCACCAATGCAGAGAACC
GAAACCCCAGCTGCGAGGTCCACCAGGAGCCGGTGACATACACAGCTATTGACCCTGGCCTGCAAGATGCTCTTCACCAGTGTGTCAACA
GCAGGTGCAGTCAGAGGCTGGAAAGTGGGGACTGTTTTGGGGTGCTGGATTGTGAATGGTGCATGGTGGACAGTGATGGAAAGACTCACC
TGGACAAACCCTACTGTGCCCCCCAGAAAGAATGCTTCGGGGGGATTGTGGGAGCCAAAAGTCCCTACGTTGATGACATGGGAGCAATAG
GTGATGAGGTGATCACATTAAACATGATTAAAAGCGCCCCTGTGGGTCCTGTGGCTGGAGGGATCATGGGATGCATCATGGTCTTGGTCC
TGGCGGTGTATGCCTACCGCCACCAGATTCATCGCCGGAGCCATCAGCATATGTCTCCTCTTGCTGCCCAAGAAATGTCAGTGCGTATGT
CCAACCTGGAGAATGACAGAGATGAAAGGGACGACGACAGCCACGAAGACAGAGGCATCATCAGCAACACTCGGTTTATAGCTGCGGTCA
TCGAACGACATGCACACAGTCCAGAAAGAAGGCGCCGCTACTGGGGTCGATCAGGAACAGAAAGTGATCATGGTTACAGCACCATGAGCC
CACAGGAGGACAGTGAAAATCCTCCATGCAACAATGACCCCTTGTCAGCCGGGGTCGATGTGGGAAACCATGATGAGGACTTAGACCTGG
ATACCCCCCCTCAGACTGCTGCCCTACTAAGTCACAAGTTCCACCACTACCGGTCACACCACCCTACACTTCATCATAGCCACCACTTAC
AGGCGGCCGTCACGGTACACACTGTCGATGCAGAATGCTAACAATCTCCTCACCTCCACGCCAAGATGAGATCTGGGAGCTACAGAATGT
TCTGGAAAGAAAAAGAACCGGCTTAAAACCCACAGCAAGAGACCTCCCTTGTGTTTGTGCTTTGTGCAGAGTTGTTTGAGTCATTTCCTG
CCTGTCGACATGGTTAAAAACGAGAGAAACAACAACACAGTCACATTTGTGAAGATGTGAGGCTGGTTCTGAAATGGAGGGGAAATAAGC
CTGATGAACAGACCTGCCATAACACTAATGGAAGGTAACAGAAGGCGAACCTCCAAACACAGAGACGGAACCTGCAAGTGAAGCTGAGCC
AGAGGAATGTTCCAAAGAGCCAGAAGCATTCAGCTCTCCTTAACTGGAAGAGAGAAAAATCTGCTCACCCAGAGACTGGAATGTGGCACA
TGCAGATACAAATGTGTGCATTGAAGATTTCGCTTTGTTTCTTAGCGGTACCTGGATACCACAGTTGCTGTATGGAACTCATGTTATGCT
CTAAACGATGCATCTCAGAATTTCTAAGTAAAGGATTATTTTTCTACTATTTATTGAACTTTCAAACATTCTCAAACTTTGGGGAAAAGG
AAAGGAAACACAGGAGAAGTTTTCAGCAGTTGCCCCGAGCTGTTTTGTGTGTAATGAAGTGGTTCTTTGATTAAGGAGCTCTATTTCTTA
TTTAACTGATATCCCACTGCCCCACTCCACAAAATAGGAAAATGAAGAAATCTTTCTCTCTGACTTGTTTACATCATTTCACGGAAACAC
ATCTTTGTTTGTAATGCAGTATTCTTTCTCTGTGTTTGACAGAGATGGGGAGGGGCAGAGGAATTTAAGAGGTTTTAAAAGAAATGTTAT
GTTTCTTATGACTTGTTTCCACTCCTCGTACAATGCTATTCTTAGGTTTCTACGAAACCTAATGTTAGAACCGCATCCTTTCAGCTAAGG
GAGGGTTGGATTTATTTTCCTTGTTTTAGAGACTACAAATTTTTAAATATCCCATTTTGACTGAGAATATTGACATATAAGGGAAGAAGT
TTTCTAAATTGTGAAAGTCTGGTTCTTAATTAAAGAATTTTTTTTTTAATATCACGGTTAAAAGCTGCTGCCAGTTAGCCAAGACATTAT
CCACCAAATTGCTTTGTGATTTATACAGGGATTAATCAAATCTGGCTACTATAACATGGGGCATTGTAACTTTAAAGTAGTGTTTTAATT
ACAGTGATGTATTTTAGACTCACATTTTGTGATTCAAATATGTTATAAAGGCATTCTTGCACCATGGTAAAGAATGTGTGTGGTAAATCT
CCGTTTATATGTAGTTGGAAAAAATTCACTGAATAATGTTTTAATGATAGGGTATTATGATACAATGTAAAAAACAATTGGTTCTTCAGC
AGTACAGAAAGTAAACTATATATGTGCTATCAGGAAACCCCTTCATACTGTGTATAAAATTGCAATCTAGTGAAATAAACCGTATGCAAT

>In-frame_ENST00000420015_ENST00000290039_TCGA-4W-AA9S-01A_PARN_chr16_14687158_-_CACHD1_chr1_65016277_length(amino acids)=1485AA_start in transcript=83_stop in transcript=4540
MRRARARVGPRFRPLCRMEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERSSPDVKFVCQSSSIDFLASQ
GFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQ
RKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQ
FYCPLPARIFNSFVYTEKISNGESEVQQLAKKIREKFNRYLDVVNRNKQVVEASYTAHLTSPLTAIQDCCTIPPSMMEFDGNFNTNVSRT
ISCDRLSTTVNSRAFNPGRDLNSVLADNLKSNPGIKWQYFSSEEGIFTVFPAHKFRCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASV
TDTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQCYKTFLSPATSETKRKMSTFVSSVKSSDSPTQHAVGFQKAFQLIRSTNN
NTKFQANTDMVIIYLSAGITSKDSSEEDKKATLQVINEENSFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKYGVPDRMALPVI
KGSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFSDEMGDGLIMTVSKPCYFGNLLLGIVGVDVNLAYILEDVTYYQDSLASYTFL
IDDKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFELVRQNILSLPLGSQIIAVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTS
FILCIVVIQPEIPVKQLKNLNTVPSSKLLYHRLDLLGQPSACLHFKQLATLESPTIMLSAGSFSSPYEHLSQPETKRMVEHYTAYLSDNT
RLIANPGLKFSVRNEVMATSHVTDEWMTQMEMSSLNTYIVRRYIATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDV
GGAGYVVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRCFIMEDRGYLVAHPTLIDPKGHAPVEQQHITH
KEPLVANDILNHPNFVKKNLCNSFSDRTVQRFYKFNTSLAGDLTNLVHGSHCSKYRLARIPGTNAFVGIVNETCDSLAFCACSMVDRLCL
NCHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEVHQEPVTYTAIDPGLQDALHQCVNSRCSQRLESGDCFGVLDCEWCMVDSDGK
THLDKPYCAPQKECFGGIVGAKSPYVDDMGAIGDEVITLNMIKSAPVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQEMSV
RMSNLENDRDERDDDSHEDRGIISNTRFIAAVIERHAHSPERRRRYWGRSGTESDHGYSTMSPQEDSENPPCNNDPLSAGVDVGNHDEDL

--------------------------------------------------------------
>In-frame_ENST00000539279_ENST00000371073_TCGA-4W-AA9S-01A_PARN_chr16_14687158_-_CACHD1_chr1_65016277_length(transcript)=5630nt_BP=506nt
GTCACCGCTGCGGCTGCCTCAGCTACTGCCGCAGTCGCCGCGGAATTCGGCGAGTAGAACCGCTGAGGCGGGCGCGGGCCCGGGTGGGGC
CAAGGTTCCGGCCACTCTGCAGAATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCACAAAGTGTACCAGGCCATAGAGGAGGCCG
ACTTCTTCGCCATCGATGGGGAGTTTTCAGGAATCAGTGATGGACCTTCAGTCTCTGCATTAACAAATGGTTTTGACACTCCAGAAGAGA
GGTATCAGAAGCTTAAAAAGAAGGAGCGATATATAGTTATCAGCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGAGCAGCAGAAACATG
CCAAAGAACAGGAGGAGCTGAATGATGCTGTGGGATTTTCTAGAGTCATTCACGCCATTGCTAATTCGGGAAAACTTGTTATTGGACACA
ATATGCTCTTGGACGTCATGCACACAGTTCATCAGTTCTACTGCCCTCTGCCTGCGCGGATATTCAACTCCTTTGTTTACACTGAGAAAA
TCTCAAATGGAGAAAGTGAAGTACAGCAGCTAGCCAAAAAAATCCGAGAGAAGTTCAACCGTTACTTGGATGTGGTCAATCGGAACAAGC
AAGTTGTAGAAGCATCCTATACGGCTCACCTAACCTCTCCCCTAACTGCAATTCAAGACTGCTGTACTATCCCACCTTCCATGATGGAAT
TCGATGGGAACTTTAATACCAATGTGTCTAGAACAATTAGTTGTGATCGACTTTCTACTACTGTTAATAGCCGGGCCTTCAATCCAGGAC
GAGACTTAAATTCAGTTCTTGCAGACAACCTGAAATCCAACCCTGGAATTAAGTGGCAATATTTCAGTTCAGAAGAAGGAATTTTCACTG
TTTTCCCAGCACACAAGTTCCGGTGTAAGGGCAGCTACGAACACCGCAGTAGACCCATCTACGTCTCTACAGTCCGGCCGCAGTCAAAGC
ACATAGTAGTGATTCTGGACCACGGGGCTTCAGTCACAGACACTCAGCTTCAGATTGCCAAGGACGCTGCTCAGGTCATCCTCAGCGCCA
TCGATGAACATGACAAGATTTCTGTGTTAACTGTGGCAGATACCGTCCGGACTTGCTCACTAGACCAGTGCTATAAGACCTTCTTGTCTC
CAGCCACCAGTGAGACAAAAAGGAAAATGTCCACCTTTGTTAGCAGCGTGAAGTCTTCAGACAGTCCTACCCAGCACGCAGTGGGATTCC
AAAAGGCATTTCAGCTGATTCGAAGTACAAACAATAACACAAAGTTCCAAGCAAATACAGACATGGTCATCATTTACCTGTCAGCTGGCA
TTACATCAAAGGACTCTTCGGAAGAAGATAAAAAAGCGACTCTCCAAGTCATCAATGAAGAAAATAGCTTTCTAAACAACTCTGTAATGA
TTCTCACCTATGCCCTCATGAACGATGGGGTGACTGGTTTGAAAGAGCTGGCTTTTCTGAGGGATCTAGCTGAACAGAATTCAGGGAAGT
ACGGTGTGCCAGACCGGATGGCCTTGCCTGTGATTAAGGGCAGCATGATGGTGCTGAATCAGTTGAGCAACCTGGAGACCACAGTGGGCA
GGTTCTACACAAACCTTCCCAACCGGATGATTGATGAAGCCGTCTTCAGCCTGCCCTTCTCTGATGAGATGGGAGATGGTTTGATAATGA
CTGTGAGTAAACCCTGTTATTTTGGAAACCTACTTCTGGGAATTGTAGGTGTGGACGTGAATCTGGCTTACATTCTTGAAGACGTGACGT
ATTACCAAGACTCTTTGGCTTCCTATACTTTTCTCATAGACGACAAAGGATATACACTTATGCACCCATCTCTTACCAGGCCATATTTAT
TGTCAGAGCCCCCACTTCATACTGACATCATACATTATGAAAATATTCCAAAATTTGAATTAGTTCGGCAAAATATCCTAAGCCTCCCTC
TGGGCAGCCAGATTATCGCAGTCCCTGTGAACTCATCCCTGTCTTGGCACATAAACAAGCTGAGAGAAACTGGAAAGGAAGCCTACAATG
TTAGCTATGCCTGGAAGATGGTACAAGACACTTCCTTTATTCTGTGTATTGTGGTGATACAACCAGAAATACCTGTGAAACAACTGAAGA
ACCTCAACACTGTTCCCAGCAGCAAGCTGCTGTACCACCGGCTGGATCTCCTTGGCCAGCCCAGTGCTTGCCTCCACTTCAAACAGCTGG
CAACCCTAGAAAGTCCCACCATCATGCTGTCTGCTGGCAGCTTTTCCTCCCCCTATGAGCACCTCAGCCAGCCAGAGACAAAGCGCATGG
TAGAGCACTACACCGCCTATCTCAGCGACAACACCCGCCTCATTGCTAACCCGGGCCTCAAATTCTCTGTCAGAAATGAAGTAATGGCTA
CCAGCCACGTCACAGATGAATGGATGACACAAATGGAAATGAGTAGCCTGAACACTTACATTGTCCGCCGTTACATAGCAACACCCAATG
GCGTCCTCAGAATTTATCCTGGTTCCCTCATGGACAAAGCATTTGATCCCACTAGGAGACAATGGTATCTCCATGCAGTAGCTAATCCAG
GGTTGATTTCTTTGACTGGTCCTTACTTAGATGTTGGAGGAGCTGGTTATGTTGTGACAATCAGTCACACAATTCATTCATCCAGTACAC
AGCTGTCTTCTGGGCACACTGTGGCTGTGATGGGCATTGACTTCACACTCAGATACTTCTACAAAGTTCTGATGGACCTATTACCTGTCT
GTAACCAAGATGGTGGCAACAAAATAAGGTGCTTCATAATGGAGGACAGGGGTTATCTGGTGGCGCACCCGACTCTCATCGACCCCAAAG
GACATGCACCTGTGGAGCAGCAGCACATCACCCACAAGGAGCCCCTGGTAGCAAATGATATCCTCAACCACCCCAACTTTGTAAAGAAAA
ACCTGTGCAACAGCTTCAGTGACAGAACGGTCCAGAGGTTTTATAAATTCAACACCAGCCTTGCGGGGGATTTGACGAACCTTGTGCATG
GCAGCCACTGTTCCAAATACAGATTAGCAAGGATCCCAGGAACCAACGCGTTTGTTGGCATTGTCAACGAAACCTGCGACTCTCTTGCCT
TCTGTGCCTGCAGCATGGTGGACCGACTCTGTCTCAACTGTCACCGAATGGAACAAAATGAATGTGAATGTCCTTGTGAGTGCCCTCTAG
AGGTCAATGAGTGCACTGGCAACCTCACCAATGCAGAGAACCGAAACCCCAGCTGCGAGGTCCACCAGGAGCCGGTGACATACACAGCTA
TTGACCCTGGCCTGCAAGATGCTCTTCACCAGTGTGTCAACAGCAGGTGCAGTCAGAGGCTGGAAAGTGGGGACTGTTTTGGGGTGCTGG
ATTGTGAATGGTGCATGGTGGACAGTGATGGAAAGACTCACCTGGACAAACCCTACTGTGCCCCCCAGAAAGAATGCTTCGGGGGGATTG
TGGGAGCCAAAAGTCCCTACGTTGATGACATGGGAGCAATAGGTGATGAGGTGATCACATTAAACATGATTAAAAGCGCCCCTGTGGGTC
CTGTGGCTGGAGGGATCATGGGATGCATCATGGTCTTGGTCCTGGCGGTGTATGCCTACCGCCACCAGATTCATCGCCGGAGCCATCAGC
ATATGTCTCCTCTTGCTGCCCAAGAAATGTCAGTGCGTATGTCCAACCTGGAGAATGACAGAGATGAAAGGGACGACGACAGCCACGAAG
ACAGAGGCATCATCAGCAACACTCGGTTTATAGCTGCGGTCATCGAACGACATGCACACAGTCCAGAAAGAAGGCGCCGCTACTGGGGTC
GATCAGGAACAGAAAGTGATCATGGTTACAGCACCATGAGCCCACAGGAGGACAGTGAAAATCCTCCATGCAACAATGACCCCTTGTCAG
CCGGGGTCGATGTGGGAAACCATGATGAGGACTTAGACCTGGATACCCCCCCTCAGACTGCTGCCCTACTAAGTCACAAGTTCCACCACT
ACCGGTCACACCACCCTACACTTCATCATAGCCACCACTTACAGGCGGCCGTCACGGTACACACTGTCGATGCAGAATGCTAACAATCTC
CTCACCTCCACGCCAAGATGAGATCTGGGAGCTACAGAATGTTCTGGAAAGAAAAAGAACCGGCTTAAAACCCACAGCAAGAGACCTCCC
TTGTGTTTGTGCTTTGTGCAGAGTTGTTTGAGTCATTTCCTGCCTGTCGACATGGTTAAAAACGAGAGAAACAACAACACAGTCACATTT
GTGAAGATGTGAGGCTGGTTCTGAAATGGAGGGGAAATAAGCCTGATGAACAGACCTGCCATAACACTAATGGAAGGTAACAGAAGGCGA
ACCTCCAAACACAGAGACGGAACCTGCAAGTGAAGCTGAGCCAGAGGAATGTTCCAAAGAGCCAGAAGCATTCAGCTCTCCTTAACTGGA
AGAGAGAAAAATCTGCTCACCCAGAGACTGGAATGTGGCACATGCAGATACAAATGTGTGCATTGAAGATTTCGCTTTGTTTCTTAGCGG
TACCTGGATACCACAGTTGCTGTATGGAACTCATGTTATGCTCTAAACGATGCATCTCAGAATTTCTAAGTAAAGGATTATTTTTCTACT
ATTTATTGAACTTTCAAACATTCTCAAACTTTGGGGAAAAGGAAAGGAAACACAGGAGAAGTTTTCAGCAGTTGCCCCGAGCTGTTTTGT
GTGTAATGAAGTGGTTCTTTGATTAAGGAGCTCTATTTCTTATTTAACTGATATCCCACTGCCCCACTCCACAAAATAGGAAAATGAAGA
AATCTTTCTCTCTGACTTGTTTACATCATTTCACGGAAACACATCTTTGTTTGTAATGCAGTATTCTTTCTCTGTGTTTGACAGAGATGG
GGAGGGGCAGAGGAATTTAAGAGGTTTTAAAAGAAATGTTATGTTTCTTATGACTTGTTTCCACTCCTCGTACAATGCTATTCTTAGGTT
TCTACGAAACCTAATGTTAGAACCGCATCCTTTCAGCTAAGGGAGGGTTGGATTTATTTTCCTTGTTTTAGAGACTACAAATTTTTAAAT
ATCCCATTTTGACTGAGAATATTGACATATAAGGGAAGAAGTTTTCTAAATTGTGAAAGTCTGGTTCTTAATTAAAGAATTTTTTTTTTA
ATATCACGGTTAAAAGCTGCTGCCAGTTAGCCAAGACATTATCCACCAAATTGCTTTGTGATTTATACAGGGATTAATCAAATCTGGCTA
CTATAACATGGGGCATTGTAACTTTAAAGTAGTGTTTTAATTACAGTGATGTATTTTAGACTCACATTTTGTGATTCAAATATGTTATAA
AGGCATTCTTGCACCATGGTAAAGAATGTGTGTGGTAAATCTCCGTTTATATGTAGTTGGAAAAAATTCACTGAATAATGTTTTAATGAT
AGGGTATTATGATACAATGTAAAAAACAATTGGTTCTTCAGCAGTACAGAAAGTAAACTATATATGTGCTATCAGGAAACCCCTTCATAC

>In-frame_ENST00000539279_ENST00000371073_TCGA-4W-AA9S-01A_PARN_chr16_14687158_-_CACHD1_chr1_65016277_length(amino acids)=1356AA_start in transcript=62_stop in transcript=4132
MRRARARVGPRFRPLCRMEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKKERYIVISKVDEEE
RKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPARIFNSFVYTEKISNGESEVQQLAKKIREKFNR
YLDVVNRNKQVVEASYTAHLTSPLTAIQDCCTIPPSMMEFDGNFNTNVSRTISCDRLSTTVNSRAFNPGRDLNSVLADNLKSNPGIKWQY
FSSEEGIFTVFPAHKFRCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASVTDTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSL
DQCYKTFLSPATSETKRKMSTFVSSVKSSDSPTQHAVGFQKAFQLIRSTNNNTKFQANTDMVIIYLSAGITSKDSSEEDKKATLQVINEE
NSFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKYGVPDRMALPVIKGSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFS
DEMGDGLIMTVSKPCYFGNLLLGIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFEL
VRQNILSLPLGSQIIAVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTSFILCIVVIQPEIPVKQLKNLNTVPSSKLLYHRLDLLGQP
SACLHFKQLATLESPTIMLSAGSFSSPYEHLSQPETKRMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQMEMSSLNTYI
VRRYIATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVGGAGYVVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFY
KVLMDLLPVCNQDGGNKIRCFIMEDRGYLVAHPTLIDPKGHAPVEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQRFYKFNTSL
AGDLTNLVHGSHCSKYRLARIPGTNAFVGIVNETCDSLAFCACSMVDRLCLNCHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEV
HQEPVTYTAIDPGLQDALHQCVNSRCSQRLESGDCFGVLDCEWCMVDSDGKTHLDKPYCAPQKECFGGIVGAKSPYVDDMGAIGDEVITL
NMIKSAPVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQEMSVRMSNLENDRDERDDDSHEDRGIISNTRFIAAVIERHAHS
PERRRRYWGRSGTESDHGYSTMSPQEDSENPPCNNDPLSAGVDVGNHDEDLDLDTPPQTAALLSHKFHHYRSHHPTLHHSHHLQAAVTVH

--------------------------------------------------------------
>In-frame_ENST00000539279_ENST00000290039_TCGA-4W-AA9S-01A_PARN_chr16_14687158_-_CACHD1_chr1_65016277_length(transcript)=5630nt_BP=506nt
GTCACCGCTGCGGCTGCCTCAGCTACTGCCGCAGTCGCCGCGGAATTCGGCGAGTAGAACCGCTGAGGCGGGCGCGGGCCCGGGTGGGGC
CAAGGTTCCGGCCACTCTGCAGAATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCACAAAGTGTACCAGGCCATAGAGGAGGCCG
ACTTCTTCGCCATCGATGGGGAGTTTTCAGGAATCAGTGATGGACCTTCAGTCTCTGCATTAACAAATGGTTTTGACACTCCAGAAGAGA
GGTATCAGAAGCTTAAAAAGAAGGAGCGATATATAGTTATCAGCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGAGCAGCAGAAACATG
CCAAAGAACAGGAGGAGCTGAATGATGCTGTGGGATTTTCTAGAGTCATTCACGCCATTGCTAATTCGGGAAAACTTGTTATTGGACACA
ATATGCTCTTGGACGTCATGCACACAGTTCATCAGTTCTACTGCCCTCTGCCTGCGCGGATATTCAACTCCTTTGTTTACACTGAGAAAA
TCTCAAATGGAGAAAGTGAAGTACAGCAGCTAGCCAAAAAAATCCGAGAGAAGTTCAACCGTTACTTGGATGTGGTCAATCGGAACAAGC
AAGTTGTAGAAGCATCCTATACGGCTCACCTAACCTCTCCCCTAACTGCAATTCAAGACTGCTGTACTATCCCACCTTCCATGATGGAAT
TCGATGGGAACTTTAATACCAATGTGTCTAGAACAATTAGTTGTGATCGACTTTCTACTACTGTTAATAGCCGGGCCTTCAATCCAGGAC
GAGACTTAAATTCAGTTCTTGCAGACAACCTGAAATCCAACCCTGGAATTAAGTGGCAATATTTCAGTTCAGAAGAAGGAATTTTCACTG
TTTTCCCAGCACACAAGTTCCGGTGTAAGGGCAGCTACGAACACCGCAGTAGACCCATCTACGTCTCTACAGTCCGGCCGCAGTCAAAGC
ACATAGTAGTGATTCTGGACCACGGGGCTTCAGTCACAGACACTCAGCTTCAGATTGCCAAGGACGCTGCTCAGGTCATCCTCAGCGCCA
TCGATGAACATGACAAGATTTCTGTGTTAACTGTGGCAGATACCGTCCGGACTTGCTCACTAGACCAGTGCTATAAGACCTTCTTGTCTC
CAGCCACCAGTGAGACAAAAAGGAAAATGTCCACCTTTGTTAGCAGCGTGAAGTCTTCAGACAGTCCTACCCAGCACGCAGTGGGATTCC
AAAAGGCATTTCAGCTGATTCGAAGTACAAACAATAACACAAAGTTCCAAGCAAATACAGACATGGTCATCATTTACCTGTCAGCTGGCA
TTACATCAAAGGACTCTTCGGAAGAAGATAAAAAAGCGACTCTCCAAGTCATCAATGAAGAAAATAGCTTTCTAAACAACTCTGTAATGA
TTCTCACCTATGCCCTCATGAACGATGGGGTGACTGGTTTGAAAGAGCTGGCTTTTCTGAGGGATCTAGCTGAACAGAATTCAGGGAAGT
ACGGTGTGCCAGACCGGATGGCCTTGCCTGTGATTAAGGGCAGCATGATGGTGCTGAATCAGTTGAGCAACCTGGAGACCACAGTGGGCA
GGTTCTACACAAACCTTCCCAACCGGATGATTGATGAAGCCGTCTTCAGCCTGCCCTTCTCTGATGAGATGGGAGATGGTTTGATAATGA
CTGTGAGTAAACCCTGTTATTTTGGAAACCTACTTCTGGGAATTGTAGGTGTGGACGTGAATCTGGCTTACATTCTTGAAGACGTGACGT
ATTACCAAGACTCTTTGGCTTCCTATACTTTTCTCATAGACGACAAAGGATATACACTTATGCACCCATCTCTTACCAGGCCATATTTAT
TGTCAGAGCCCCCACTTCATACTGACATCATACATTATGAAAATATTCCAAAATTTGAATTAGTTCGGCAAAATATCCTAAGCCTCCCTC
TGGGCAGCCAGATTATCGCAGTCCCTGTGAACTCATCCCTGTCTTGGCACATAAACAAGCTGAGAGAAACTGGAAAGGAAGCCTACAATG
TTAGCTATGCCTGGAAGATGGTACAAGACACTTCCTTTATTCTGTGTATTGTGGTGATACAACCAGAAATACCTGTGAAACAACTGAAGA
ACCTCAACACTGTTCCCAGCAGCAAGCTGCTGTACCACCGGCTGGATCTCCTTGGCCAGCCCAGTGCTTGCCTCCACTTCAAACAGCTGG
CAACCCTAGAAAGTCCCACCATCATGCTGTCTGCTGGCAGCTTTTCCTCCCCCTATGAGCACCTCAGCCAGCCAGAGACAAAGCGCATGG
TAGAGCACTACACCGCCTATCTCAGCGACAACACCCGCCTCATTGCTAACCCGGGCCTCAAATTCTCTGTCAGAAATGAAGTAATGGCTA
CCAGCCACGTCACAGATGAATGGATGACACAAATGGAAATGAGTAGCCTGAACACTTACATTGTCCGCCGTTACATAGCAACACCCAATG
GCGTCCTCAGAATTTATCCTGGTTCCCTCATGGACAAAGCATTTGATCCCACTAGGAGACAATGGTATCTCCATGCAGTAGCTAATCCAG
GGTTGATTTCTTTGACTGGTCCTTACTTAGATGTTGGAGGAGCTGGTTATGTTGTGACAATCAGTCACACAATTCATTCATCCAGTACAC
AGCTGTCTTCTGGGCACACTGTGGCTGTGATGGGCATTGACTTCACACTCAGATACTTCTACAAAGTTCTGATGGACCTATTACCTGTCT
GTAACCAAGATGGTGGCAACAAAATAAGGTGCTTCATAATGGAGGACAGGGGTTATCTGGTGGCGCACCCGACTCTCATCGACCCCAAAG
GACATGCACCTGTGGAGCAGCAGCACATCACCCACAAGGAGCCCCTGGTAGCAAATGATATCCTCAACCACCCCAACTTTGTAAAGAAAA
ACCTGTGCAACAGCTTCAGTGACAGAACGGTCCAGAGGTTTTATAAATTCAACACCAGCCTTGCGGGGGATTTGACGAACCTTGTGCATG
GCAGCCACTGTTCCAAATACAGATTAGCAAGGATCCCAGGAACCAACGCGTTTGTTGGCATTGTCAACGAAACCTGCGACTCTCTTGCCT
TCTGTGCCTGCAGCATGGTGGACCGACTCTGTCTCAACTGTCACCGAATGGAACAAAATGAATGTGAATGTCCTTGTGAGTGCCCTCTAG
AGGTCAATGAGTGCACTGGCAACCTCACCAATGCAGAGAACCGAAACCCCAGCTGCGAGGTCCACCAGGAGCCGGTGACATACACAGCTA
TTGACCCTGGCCTGCAAGATGCTCTTCACCAGTGTGTCAACAGCAGGTGCAGTCAGAGGCTGGAAAGTGGGGACTGTTTTGGGGTGCTGG
ATTGTGAATGGTGCATGGTGGACAGTGATGGAAAGACTCACCTGGACAAACCCTACTGTGCCCCCCAGAAAGAATGCTTCGGGGGGATTG
TGGGAGCCAAAAGTCCCTACGTTGATGACATGGGAGCAATAGGTGATGAGGTGATCACATTAAACATGATTAAAAGCGCCCCTGTGGGTC
CTGTGGCTGGAGGGATCATGGGATGCATCATGGTCTTGGTCCTGGCGGTGTATGCCTACCGCCACCAGATTCATCGCCGGAGCCATCAGC
ATATGTCTCCTCTTGCTGCCCAAGAAATGTCAGTGCGTATGTCCAACCTGGAGAATGACAGAGATGAAAGGGACGACGACAGCCACGAAG
ACAGAGGCATCATCAGCAACACTCGGTTTATAGCTGCGGTCATCGAACGACATGCACACAGTCCAGAAAGAAGGCGCCGCTACTGGGGTC
GATCAGGAACAGAAAGTGATCATGGTTACAGCACCATGAGCCCACAGGAGGACAGTGAAAATCCTCCATGCAACAATGACCCCTTGTCAG
CCGGGGTCGATGTGGGAAACCATGATGAGGACTTAGACCTGGATACCCCCCCTCAGACTGCTGCCCTACTAAGTCACAAGTTCCACCACT
ACCGGTCACACCACCCTACACTTCATCATAGCCACCACTTACAGGCGGCCGTCACGGTACACACTGTCGATGCAGAATGCTAACAATCTC
CTCACCTCCACGCCAAGATGAGATCTGGGAGCTACAGAATGTTCTGGAAAGAAAAAGAACCGGCTTAAAACCCACAGCAAGAGACCTCCC
TTGTGTTTGTGCTTTGTGCAGAGTTGTTTGAGTCATTTCCTGCCTGTCGACATGGTTAAAAACGAGAGAAACAACAACACAGTCACATTT
GTGAAGATGTGAGGCTGGTTCTGAAATGGAGGGGAAATAAGCCTGATGAACAGACCTGCCATAACACTAATGGAAGGTAACAGAAGGCGA
ACCTCCAAACACAGAGACGGAACCTGCAAGTGAAGCTGAGCCAGAGGAATGTTCCAAAGAGCCAGAAGCATTCAGCTCTCCTTAACTGGA
AGAGAGAAAAATCTGCTCACCCAGAGACTGGAATGTGGCACATGCAGATACAAATGTGTGCATTGAAGATTTCGCTTTGTTTCTTAGCGG
TACCTGGATACCACAGTTGCTGTATGGAACTCATGTTATGCTCTAAACGATGCATCTCAGAATTTCTAAGTAAAGGATTATTTTTCTACT
ATTTATTGAACTTTCAAACATTCTCAAACTTTGGGGAAAAGGAAAGGAAACACAGGAGAAGTTTTCAGCAGTTGCCCCGAGCTGTTTTGT
GTGTAATGAAGTGGTTCTTTGATTAAGGAGCTCTATTTCTTATTTAACTGATATCCCACTGCCCCACTCCACAAAATAGGAAAATGAAGA
AATCTTTCTCTCTGACTTGTTTACATCATTTCACGGAAACACATCTTTGTTTGTAATGCAGTATTCTTTCTCTGTGTTTGACAGAGATGG
GGAGGGGCAGAGGAATTTAAGAGGTTTTAAAAGAAATGTTATGTTTCTTATGACTTGTTTCCACTCCTCGTACAATGCTATTCTTAGGTT
TCTACGAAACCTAATGTTAGAACCGCATCCTTTCAGCTAAGGGAGGGTTGGATTTATTTTCCTTGTTTTAGAGACTACAAATTTTTAAAT
ATCCCATTTTGACTGAGAATATTGACATATAAGGGAAGAAGTTTTCTAAATTGTGAAAGTCTGGTTCTTAATTAAAGAATTTTTTTTTTA
ATATCACGGTTAAAAGCTGCTGCCAGTTAGCCAAGACATTATCCACCAAATTGCTTTGTGATTTATACAGGGATTAATCAAATCTGGCTA
CTATAACATGGGGCATTGTAACTTTAAAGTAGTGTTTTAATTACAGTGATGTATTTTAGACTCACATTTTGTGATTCAAATATGTTATAA
AGGCATTCTTGCACCATGGTAAAGAATGTGTGTGGTAAATCTCCGTTTATATGTAGTTGGAAAAAATTCACTGAATAATGTTTTAATGAT
AGGGTATTATGATACAATGTAAAAAACAATTGGTTCTTCAGCAGTACAGAAAGTAAACTATATATGTGCTATCAGGAAACCCCTTCATAC

>In-frame_ENST00000539279_ENST00000290039_TCGA-4W-AA9S-01A_PARN_chr16_14687158_-_CACHD1_chr1_65016277_length(amino acids)=1356AA_start in transcript=62_stop in transcript=4132
MRRARARVGPRFRPLCRMEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKKERYIVISKVDEEE
RKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPARIFNSFVYTEKISNGESEVQQLAKKIREKFNR
YLDVVNRNKQVVEASYTAHLTSPLTAIQDCCTIPPSMMEFDGNFNTNVSRTISCDRLSTTVNSRAFNPGRDLNSVLADNLKSNPGIKWQY
FSSEEGIFTVFPAHKFRCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASVTDTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSL
DQCYKTFLSPATSETKRKMSTFVSSVKSSDSPTQHAVGFQKAFQLIRSTNNNTKFQANTDMVIIYLSAGITSKDSSEEDKKATLQVINEE
NSFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKYGVPDRMALPVIKGSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFS
DEMGDGLIMTVSKPCYFGNLLLGIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFEL
VRQNILSLPLGSQIIAVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTSFILCIVVIQPEIPVKQLKNLNTVPSSKLLYHRLDLLGQP
SACLHFKQLATLESPTIMLSAGSFSSPYEHLSQPETKRMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQMEMSSLNTYI
VRRYIATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVGGAGYVVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFY
KVLMDLLPVCNQDGGNKIRCFIMEDRGYLVAHPTLIDPKGHAPVEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQRFYKFNTSL
AGDLTNLVHGSHCSKYRLARIPGTNAFVGIVNETCDSLAFCACSMVDRLCLNCHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEV
HQEPVTYTAIDPGLQDALHQCVNSRCSQRLESGDCFGVLDCEWCMVDSDGKTHLDKPYCAPQKECFGGIVGAKSPYVDDMGAIGDEVITL
NMIKSAPVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQEMSVRMSNLENDRDERDDDSHEDRGIISNTRFIAAVIERHAHS
PERRRRYWGRSGTESDHGYSTMSPQEDSENPPCNNDPLSAGVDVGNHDEDLDLDTPPQTAALLSHKFHHYRSHHPTLHHSHHLQAAVTVH

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Fusion Gene PPI Analysis for PARN-CACHD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PARN-CACHD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PARN-CACHD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePARNC4225347PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 44CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePARNC4225356DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 63CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePARNC0265965Dyskeratosis Congenita2GENOMICS_ENGLAND;ORPHANET
HgenePARNC0085786Hamman-Rich syndrome1ORPHANET
HgenePARNC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET
HgenePARNC1846142HOYERAAL-HREIDARSSON SYNDROME1ORPHANET
HgenePARNC4721508Hamman-Rich Disease1CTD_human
HgenePARNC4721509Usual Interstitial Pneumonia1CTD_human
HgenePARNC4721952Familial Idiopathic Pulmonary Fibrosis1CTD_human