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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ARHGDIA-CDC27 (FusionGDB2 ID:6262) |
Fusion Gene Summary for ARHGDIA-CDC27 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGDIA-CDC27 | Fusion gene ID: 6262 | Hgene | Tgene | Gene symbol | ARHGDIA | CDC27 | Gene ID | 396 | 996 |
| Gene name | Rho GDP dissociation inhibitor alpha | cell division cycle 27 | |
| Synonyms | GDIA1|HEL-S-47e|NPHS8|RHOGDI|RHOGDI-1 | ANAPC3|APC3|CDC27Hs|D0S1430E|D17S978E|H-NUC|HNUC|NUC2 | |
| Cytomap | 17q25.3 | 17q21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho GDP-dissociation inhibitor 1GDP-dissociation inhibitor, aplysia RAS-related 1Rho GDP dissociation inhibitor (GDI) alphaepididymis secretory sperm binding protein Li 47e | cell division cycle protein 27 homologD0S1430E, D17S978Eanaphase promoting complex subunit 3anaphase-promoting complex, protein 3cell division cycle 27 homolognuc2 homolog | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | P52565 | P30260 | |
| Ensembl transtripts involved in fusion gene | ENST00000582520, ENST00000269321, ENST00000400721, ENST00000584461, ENST00000541078, ENST00000580685, ENST00000581876, | ENST00000066544, ENST00000531206, ENST00000446365, ENST00000527547, ENST00000528748, | |
| Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 7 X 7 X 4=196 |
| # samples | 7 | 8 | |
| ** MAII score | log2(7/112*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARHGDIA [Title/Abstract] AND CDC27 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ARHGDIA(79827341)-CDC27(45214727), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CDC27 | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
| Fusion gene breakpoints across ARHGDIA (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across CDC27 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | HNSC | TCGA-HD-7754 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
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Fusion Gene ORF analysis for ARHGDIA-CDC27 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000582520 | ENST00000066544 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000582520 | ENST00000531206 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000582520 | ENST00000446365 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000582520 | ENST00000527547 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-intron | ENST00000582520 | ENST00000528748 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000269321 | ENST00000066544 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000269321 | ENST00000531206 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000269321 | ENST00000446365 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000269321 | ENST00000527547 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-intron | ENST00000269321 | ENST00000528748 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000400721 | ENST00000066544 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000400721 | ENST00000531206 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000400721 | ENST00000446365 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000400721 | ENST00000527547 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-intron | ENST00000400721 | ENST00000528748 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000584461 | ENST00000066544 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000584461 | ENST00000531206 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000584461 | ENST00000446365 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000584461 | ENST00000527547 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-intron | ENST00000584461 | ENST00000528748 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000541078 | ENST00000066544 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000541078 | ENST00000531206 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000541078 | ENST00000446365 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000541078 | ENST00000527547 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-intron | ENST00000541078 | ENST00000528748 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000580685 | ENST00000066544 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000580685 | ENST00000531206 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000580685 | ENST00000446365 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000580685 | ENST00000527547 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-intron | ENST00000580685 | ENST00000528748 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000581876 | ENST00000066544 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000581876 | ENST00000531206 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000581876 | ENST00000446365 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-3CDS | ENST00000581876 | ENST00000527547 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| intron-intron | ENST00000581876 | ENST00000528748 | ARHGDIA | chr17 | 79827341 | - | CDC27 | chr17 | 45214727 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ARHGDIA-CDC27 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ARHGDIA-CDC27 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGDIA | CDC27 |
| FUNCTION: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. | FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ARHGDIA-CDC27 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for ARHGDIA-CDC27 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARHGDIA-CDC27 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARHGDIA-CDC27 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ARHGDIA | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| Hgene | ARHGDIA | C0019693 | HIV Infections | 1 | CTD_human |
| Hgene | ARHGDIA | C0022548 | Keloid | 1 | CTD_human |
| Hgene | ARHGDIA | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | ARHGDIA | C0678222 | Breast Carcinoma | 1 | CTD_human |
| Hgene | ARHGDIA | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| Hgene | ARHGDIA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | ARHGDIA | C1868672 | NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE | 1 | ORPHANET |
| Hgene | ARHGDIA | C3808874 | ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 2 | 1 | GENOMICS_ENGLAND |
| Hgene | ARHGDIA | C4505456 | HIV Coinfection | 1 | CTD_human |
| Hgene | ARHGDIA | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
| Tgene | CDC27 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | CDC27 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
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