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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PBX1-LRRC52 (FusionGDB2 ID:62623)

Fusion Gene Summary for PBX1-LRRC52

check button Fusion gene summary
Fusion gene informationFusion gene name: PBX1-LRRC52
Fusion gene ID: 62623
HgeneTgene
Gene symbol

PBX1

LRRC52

Gene ID

5087

440699

Gene namePBX homeobox 1leucine rich repeat containing 52
SynonymsCAKUHED-
Cytomap

1q23.3

1q24.1

Type of geneprotein-codingprotein-coding
Descriptionpre-B-cell leukemia transcription factor 1homeobox protein PBX1homeobox protein PRLpre-B-cell leukemia homeobox 1leucine-rich repeat-containing protein 52BK channel auxiliary gamma subunit LRRC52BK channel auxilliary gamma subunit LRRC52
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000420696, ENST00000401534, 
ENST00000559240, ENST00000367897, 
ENST00000540236, ENST00000560641, 
ENST00000474046, ENST00000485769, 
ENST00000540246, 		ENST00000294818, 
Fusion gene scores* DoF score16 X 10 X 5=8004 X 3 X 4=48
# samples 216
** MAII scorelog2(21/800*10)=-1.9296106721086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PBX1 [Title/Abstract] AND LRRC52 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPBX1(164532548)-LRRC52(165532742), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLRRC52

GO:0071805

potassium ion transmembrane transport

22547800

TgeneLRRC52

GO:1903818

positive regulation of voltage-gated potassium channel activity

22547800


check buttonFusion gene breakpoints across PBX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LRRC52 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-GI-A2C8-01APBX1chr1

164532548

+LRRC52chr1

165532742

+
ChimerDB4BRCATCGA-GI-A2C8PBX1chr1

164532548

+LRRC52chr1

165532741

+
ChimerDB4BRCATCGA-GI-A2C8-01APBX1chr1

164532548

+LRRC52chr1

165532742

+
ChimerDB4BRCATCGA-GI-A2C8-01APBX1chr1

164532548

+LRRC52chr1

165513908

+
ChimerDB4BRCATCGA-GI-A2C8-01APBX1chr1

164532548

-LRRC52chr1

165532742

+


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Fusion Gene ORF analysis for PBX1-LRRC52

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000420696ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532742

+
In-frameENST00000401534ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532742

+
In-frameENST00000559240ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532742

+
In-frameENST00000367897ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532742

+
In-frameENST00000540236ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532742

+
intron-3CDSENST00000560641ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532742

+
intron-3CDSENST00000474046ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532742

+
intron-3CDSENST00000485769ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532742

+
intron-3CDSENST00000540246ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532742

+
In-frameENST00000420696ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532741

+
In-frameENST00000401534ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532741

+
In-frameENST00000559240ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532741

+
In-frameENST00000367897ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532741

+
In-frameENST00000540236ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532741

+
intron-3CDSENST00000560641ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532741

+
intron-3CDSENST00000474046ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532741

+
intron-3CDSENST00000485769ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532741

+
intron-3CDSENST00000540246ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165532741

+
In-frameENST00000420696ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165513908

+
In-frameENST00000401534ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165513908

+
In-frameENST00000559240ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165513908

+
In-frameENST00000367897ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165513908

+
In-frameENST00000540236ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165513908

+
intron-3CDSENST00000560641ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165513908

+
intron-3CDSENST00000474046ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165513908

+
intron-3CDSENST00000485769ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165513908

+
intron-3CDSENST00000540246ENST00000294818PBX1chr1

164532548

+LRRC52chr1

165513908

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000420696PBX1chr1164532548+ENST00000294818LRRC52chr1165532742+910453182772196
ENST00000401534PBX1chr1164532548+ENST00000294818LRRC52chr1165532742+7222650584194
ENST00000559240PBX1chr1164532548+ENST00000294818LRRC52chr1165532742+7222650584194
ENST00000367897PBX1chr1164532548+ENST00000294818LRRC52chr1165532742+7222650584194
ENST00000540236PBX1chr1164532548+ENST00000294818LRRC52chr1165532742+7222650584194
ENST00000420696PBX1chr1164532548+ENST00000294818LRRC52chr1165532741+910453182772196
ENST00000401534PBX1chr1164532548+ENST00000294818LRRC52chr1165532741+7222650584194
ENST00000559240PBX1chr1164532548+ENST00000294818LRRC52chr1165532741+7222650584194
ENST00000367897PBX1chr1164532548+ENST00000294818LRRC52chr1165532741+7222650584194
ENST00000540236PBX1chr1164532548+ENST00000294818LRRC52chr1165532741+7222650584194
ENST00000420696PBX1chr1164532548+ENST00000294818LRRC52chr1165513908+11574534111019202
ENST00000401534PBX1chr1164532548+ENST00000294818LRRC52chr1165513908+969265223831202
ENST00000559240PBX1chr1164532548+ENST00000294818LRRC52chr1165513908+969265223831202
ENST00000367897PBX1chr1164532548+ENST00000294818LRRC52chr1165513908+969265223831202
ENST00000540236PBX1chr1164532548+ENST00000294818LRRC52chr1165513908+969265223831202

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000420696ENST00000294818PBX1chr1164532548+LRRC52chr1165532742+0.009354560.9906454
ENST00000401534ENST00000294818PBX1chr1164532548+LRRC52chr1165532742+0.0055838960.9944161
ENST00000559240ENST00000294818PBX1chr1164532548+LRRC52chr1165532742+0.0055838960.9944161
ENST00000367897ENST00000294818PBX1chr1164532548+LRRC52chr1165532742+0.0055838960.9944161
ENST00000540236ENST00000294818PBX1chr1164532548+LRRC52chr1165532742+0.0055838960.9944161
ENST00000420696ENST00000294818PBX1chr1164532548+LRRC52chr1165532741+0.009354560.9906454
ENST00000401534ENST00000294818PBX1chr1164532548+LRRC52chr1165532741+0.0055838960.9944161
ENST00000559240ENST00000294818PBX1chr1164532548+LRRC52chr1165532741+0.0055838960.9944161
ENST00000367897ENST00000294818PBX1chr1164532548+LRRC52chr1165532741+0.0055838960.9944161
ENST00000540236ENST00000294818PBX1chr1164532548+LRRC52chr1165532741+0.0055838960.9944161
ENST00000420696ENST00000294818PBX1chr1164532548+LRRC52chr1165513908+0.0263530160.97364694
ENST00000401534ENST00000294818PBX1chr1164532548+LRRC52chr1165513908+0.0225099060.9774901
ENST00000559240ENST00000294818PBX1chr1164532548+LRRC52chr1165513908+0.0225099060.9774901
ENST00000367897ENST00000294818PBX1chr1164532548+LRRC52chr1165513908+0.0225099060.9774901
ENST00000540236ENST00000294818PBX1chr1164532548+LRRC52chr1165513908+0.0225099060.9774901

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Fusion Genomic Features for PBX1-LRRC52


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PBX1chr1164532548+LRRC52chr1165532741+3.46E-060.99999654
PBX1chr1164532548+LRRC52chr1165532741+3.46E-060.99999654
PBX1chr1164532548+LRRC52chr1165532741+3.46E-060.99999654
PBX1chr1164532548+LRRC52chr1165532741+3.46E-060.99999654

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PBX1-LRRC52


check button Go to

FGviewer for the breakpoints of chr1:164532548-chr1:165532742

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRC52chr1:164532548chr1:165513908ENST0000029481802184_2380314.0DomainNote=LRRCT
TgeneLRRC52chr1:164532548chr1:165513908ENST000002948180224_530314.0DomainNote=LRRNT
TgeneLRRC52chr1:164532548chr1:165513908ENST0000029481802102_1230314.0RepeatNote=LRR 3
TgeneLRRC52chr1:164532548chr1:165513908ENST0000029481802126_1480314.0RepeatNote=LRR 4
TgeneLRRC52chr1:164532548chr1:165513908ENST0000029481802151_1720314.0RepeatNote=LRR 5
TgeneLRRC52chr1:164532548chr1:165513908ENST000002948180254_750314.0RepeatNote=LRR 1
TgeneLRRC52chr1:164532548chr1:165513908ENST000002948180278_990314.0RepeatNote=LRR 2
TgeneLRRC52chr1:164532548chr1:165513908ENST000002948180224_2440314.0Topological domainExtracellular
TgeneLRRC52chr1:164532548chr1:165513908ENST0000029481802266_3130314.0Topological domainCytoplasmic
TgeneLRRC52chr1:164532548chr1:165532741ENST0000029481802266_313207.33333333333334314.0Topological domainCytoplasmic
TgeneLRRC52chr1:164532548chr1:165532742ENST0000029481802266_313207.33333333333334314.0Topological domainCytoplasmic
TgeneLRRC52chr1:164532548chr1:165513908ENST0000029481802245_2650314.0TransmembraneHelical
TgeneLRRC52chr1:164532548chr1:165532741ENST0000029481802245_265207.33333333333334314.0TransmembraneHelical
TgeneLRRC52chr1:164532548chr1:165532742ENST0000029481802245_265207.33333333333334314.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBX1chr1:164532548chr1:165513908ENST00000367897+28127_13588.33333333333333408.3333333333333Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:165513908ENST00000401534+27127_13588.33333333333333348.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:165513908ENST00000420696+29127_13588.33333333333333431.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:165513908ENST00000540236+29127_13588.33333333333333421.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:165532741ENST00000367897+28127_13588.33333333333333408.3333333333333Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:165532741ENST00000401534+27127_13588.33333333333333348.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:165532741ENST00000420696+29127_13588.33333333333333431.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:165532741ENST00000540236+29127_13588.33333333333333421.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:165532742ENST00000367897+28127_13588.33333333333333408.3333333333333Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:165532742ENST00000401534+27127_13588.33333333333333348.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:165532742ENST00000420696+29127_13588.33333333333333431.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:165532742ENST00000540236+29127_13588.33333333333333421.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:165513908ENST00000367897+28233_29588.33333333333333408.3333333333333DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:165513908ENST00000401534+27233_29588.33333333333333348.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:165513908ENST00000420696+29233_29588.33333333333333431.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:165513908ENST00000540236+29233_29588.33333333333333421.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:165532741ENST00000367897+28233_29588.33333333333333408.3333333333333DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:165532741ENST00000401534+27233_29588.33333333333333348.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:165532741ENST00000420696+29233_29588.33333333333333431.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:165532741ENST00000540236+29233_29588.33333333333333421.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:165532742ENST00000367897+28233_29588.33333333333333408.3333333333333DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:165532742ENST00000401534+27233_29588.33333333333333348.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:165532742ENST00000420696+29233_29588.33333333333333431.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:165532742ENST00000540236+29233_29588.33333333333333421.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:165513908ENST00000367897+2840_23288.33333333333333408.3333333333333DomainPBC
HgenePBX1chr1:164532548chr1:165513908ENST00000401534+2740_23288.33333333333333348.0DomainPBC
HgenePBX1chr1:164532548chr1:165513908ENST00000420696+2940_23288.33333333333333431.0DomainPBC
HgenePBX1chr1:164532548chr1:165513908ENST00000540236+2940_23288.33333333333333421.0DomainPBC
HgenePBX1chr1:164532548chr1:165532741ENST00000367897+2840_23288.33333333333333408.3333333333333DomainPBC
HgenePBX1chr1:164532548chr1:165532741ENST00000401534+2740_23288.33333333333333348.0DomainPBC
HgenePBX1chr1:164532548chr1:165532741ENST00000420696+2940_23288.33333333333333431.0DomainPBC
HgenePBX1chr1:164532548chr1:165532741ENST00000540236+2940_23288.33333333333333421.0DomainPBC
HgenePBX1chr1:164532548chr1:165532742ENST00000367897+2840_23288.33333333333333408.3333333333333DomainPBC
HgenePBX1chr1:164532548chr1:165532742ENST00000401534+2740_23288.33333333333333348.0DomainPBC
HgenePBX1chr1:164532548chr1:165532742ENST00000420696+2940_23288.33333333333333431.0DomainPBC
HgenePBX1chr1:164532548chr1:165532742ENST00000540236+2940_23288.33333333333333421.0DomainPBC
TgeneLRRC52chr1:164532548chr1:165532741ENST0000029481802184_238207.33333333333334314.0DomainNote=LRRCT
TgeneLRRC52chr1:164532548chr1:165532741ENST000002948180224_53207.33333333333334314.0DomainNote=LRRNT
TgeneLRRC52chr1:164532548chr1:165532742ENST0000029481802184_238207.33333333333334314.0DomainNote=LRRCT
TgeneLRRC52chr1:164532548chr1:165532742ENST000002948180224_53207.33333333333334314.0DomainNote=LRRNT
TgeneLRRC52chr1:164532548chr1:165532741ENST0000029481802102_123207.33333333333334314.0RepeatNote=LRR 3
TgeneLRRC52chr1:164532548chr1:165532741ENST0000029481802126_148207.33333333333334314.0RepeatNote=LRR 4
TgeneLRRC52chr1:164532548chr1:165532741ENST0000029481802151_172207.33333333333334314.0RepeatNote=LRR 5
TgeneLRRC52chr1:164532548chr1:165532741ENST000002948180254_75207.33333333333334314.0RepeatNote=LRR 1
TgeneLRRC52chr1:164532548chr1:165532741ENST000002948180278_99207.33333333333334314.0RepeatNote=LRR 2
TgeneLRRC52chr1:164532548chr1:165532742ENST0000029481802102_123207.33333333333334314.0RepeatNote=LRR 3
TgeneLRRC52chr1:164532548chr1:165532742ENST0000029481802126_148207.33333333333334314.0RepeatNote=LRR 4
TgeneLRRC52chr1:164532548chr1:165532742ENST0000029481802151_172207.33333333333334314.0RepeatNote=LRR 5
TgeneLRRC52chr1:164532548chr1:165532742ENST000002948180254_75207.33333333333334314.0RepeatNote=LRR 1
TgeneLRRC52chr1:164532548chr1:165532742ENST000002948180278_99207.33333333333334314.0RepeatNote=LRR 2
TgeneLRRC52chr1:164532548chr1:165532741ENST000002948180224_244207.33333333333334314.0Topological domainExtracellular
TgeneLRRC52chr1:164532548chr1:165532742ENST000002948180224_244207.33333333333334314.0Topological domainExtracellular


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Fusion Gene Sequence for PBX1-LRRC52


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000420696_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165532742_length(transcript)=910nt_BP=453nt
ATCCTCCCACCATCCTCTAAAGAGGCAAAGGGATTTTTTTTTTCTTTTGGTCTTCTTTTTTCCCCCTTCCCTGTTTATCCTGAAAAGGAT
TTGAAGACAAGCTTGAAGGATAAAAAGCCTTGGTGCTTCCCAGGAGCCGAGCCGAGGAGCAGAAGAGGAAGAGCCGGGGGCTGCCGTAGC
CTTTGGAGATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGG
ATGGGGCCGGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTT
TGGATGAGGCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAA
CAGATGATCTAAATGCCACATGTGTGGAGCCCACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCA
TCACGCACCTGGACCACAAAGACTACATCTTCCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAG
GTGTGTGTGCTGTGCTCTACCAGAACACCCGCCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGC
GGATTTTTCAAACCCAGACGAGCTCGGTCCAGGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGC
TCCCTGCTTTCTCTCTTGCCCTCCCCATCCCACCACCTTGGAGCTGTCATAGAGATTGAAACCTTCTAGTAAAATAAATAAAATCTCTGA

>In-frame_ENST00000420696_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165532742_length(amino acids)=196AA_start in transcript=182_stop in transcript=772
MEMDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKT
DDLNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRR

--------------------------------------------------------------
>In-frame_ENST00000401534_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165532742_length(transcript)=722nt_BP=265nt
ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGGATGGGGCC
GGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG
GCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAACAGATGAT
CTAAATGCCACATGTGTGGAGCCCACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCAC
CTGGACCACAAAGACTACATCTTCCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGT
GCTGTGCTCTACCAGAACACCCGCCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTT
CAAACCCAGACGAGCTCGGTCCAGGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCT
TTCTCTCTTGCCCTCCCCATCCCACCACCTTGGAGCTGTCATAGAGATTGAAACCTTCTAGTAAAATAAATAAAATCTCTGATGGCCATT

>In-frame_ENST00000401534_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165532742_length(amino acids)=194AA_start in transcript=0_stop in transcript=584
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDD
LNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIF

--------------------------------------------------------------
>In-frame_ENST00000559240_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165532742_length(transcript)=722nt_BP=265nt
ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGGATGGGGCC
GGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG
GCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAACAGATGAT
CTAAATGCCACATGTGTGGAGCCCACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCAC
CTGGACCACAAAGACTACATCTTCCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGT
GCTGTGCTCTACCAGAACACCCGCCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTT
CAAACCCAGACGAGCTCGGTCCAGGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCT
TTCTCTCTTGCCCTCCCCATCCCACCACCTTGGAGCTGTCATAGAGATTGAAACCTTCTAGTAAAATAAATAAAATCTCTGATGGCCATT

>In-frame_ENST00000559240_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165532742_length(amino acids)=194AA_start in transcript=0_stop in transcript=584
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDD
LNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIF

--------------------------------------------------------------
>In-frame_ENST00000367897_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165532742_length(transcript)=722nt_BP=265nt
ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGGATGGGGCC
GGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG
GCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAACAGATGAT
CTAAATGCCACATGTGTGGAGCCCACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCAC
CTGGACCACAAAGACTACATCTTCCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGT
GCTGTGCTCTACCAGAACACCCGCCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTT
CAAACCCAGACGAGCTCGGTCCAGGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCT
TTCTCTCTTGCCCTCCCCATCCCACCACCTTGGAGCTGTCATAGAGATTGAAACCTTCTAGTAAAATAAATAAAATCTCTGATGGCCATT

>In-frame_ENST00000367897_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165532742_length(amino acids)=194AA_start in transcript=0_stop in transcript=584
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDD
LNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIF

--------------------------------------------------------------
>In-frame_ENST00000540236_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165532742_length(transcript)=722nt_BP=265nt
ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGGATGGGGCC
GGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG
GCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAACAGATGAT
CTAAATGCCACATGTGTGGAGCCCACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCAC
CTGGACCACAAAGACTACATCTTCCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGT
GCTGTGCTCTACCAGAACACCCGCCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTT
CAAACCCAGACGAGCTCGGTCCAGGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCT
TTCTCTCTTGCCCTCCCCATCCCACCACCTTGGAGCTGTCATAGAGATTGAAACCTTCTAGTAAAATAAATAAAATCTCTGATGGCCATT

>In-frame_ENST00000540236_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165532742_length(amino acids)=194AA_start in transcript=0_stop in transcript=584
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDD
LNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIF

--------------------------------------------------------------
>In-frame_ENST00000420696_ENST00000294818_TCGA-GI-A2C8_PBX1_chr1_164532548_+_LRRC52_chr1_165532741_length(transcript)=910nt_BP=453nt
ATCCTCCCACCATCCTCTAAAGAGGCAAAGGGATTTTTTTTTTCTTTTGGTCTTCTTTTTTCCCCCTTCCCTGTTTATCCTGAAAAGGAT
TTGAAGACAAGCTTGAAGGATAAAAAGCCTTGGTGCTTCCCAGGAGCCGAGCCGAGGAGCAGAAGAGGAAGAGCCGGGGGCTGCCGTAGC
CTTTGGAGATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGG
ATGGGGCCGGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTT
TGGATGAGGCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAA
CAGATGATCTAAATGCCACATGTGTGGAGCCCACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCA
TCACGCACCTGGACCACAAAGACTACATCTTCCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAG
GTGTGTGTGCTGTGCTCTACCAGAACACCCGCCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGC
GGATTTTTCAAACCCAGACGAGCTCGGTCCAGGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGC
TCCCTGCTTTCTCTCTTGCCCTCCCCATCCCACCACCTTGGAGCTGTCATAGAGATTGAAACCTTCTAGTAAAATAAATAAAATCTCTGA

>In-frame_ENST00000420696_ENST00000294818_TCGA-GI-A2C8_PBX1_chr1_164532548_+_LRRC52_chr1_165532741_length(amino acids)=196AA_start in transcript=182_stop in transcript=772
MEMDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKT
DDLNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRR

--------------------------------------------------------------
>In-frame_ENST00000401534_ENST00000294818_TCGA-GI-A2C8_PBX1_chr1_164532548_+_LRRC52_chr1_165532741_length(transcript)=722nt_BP=265nt
ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGGATGGGGCC
GGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG
GCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAACAGATGAT
CTAAATGCCACATGTGTGGAGCCCACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCAC
CTGGACCACAAAGACTACATCTTCCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGT
GCTGTGCTCTACCAGAACACCCGCCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTT
CAAACCCAGACGAGCTCGGTCCAGGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCT
TTCTCTCTTGCCCTCCCCATCCCACCACCTTGGAGCTGTCATAGAGATTGAAACCTTCTAGTAAAATAAATAAAATCTCTGATGGCCATT

>In-frame_ENST00000401534_ENST00000294818_TCGA-GI-A2C8_PBX1_chr1_164532548_+_LRRC52_chr1_165532741_length(amino acids)=194AA_start in transcript=0_stop in transcript=584
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDD
LNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIF

--------------------------------------------------------------
>In-frame_ENST00000559240_ENST00000294818_TCGA-GI-A2C8_PBX1_chr1_164532548_+_LRRC52_chr1_165532741_length(transcript)=722nt_BP=265nt
ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGGATGGGGCC
GGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG
GCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAACAGATGAT
CTAAATGCCACATGTGTGGAGCCCACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCAC
CTGGACCACAAAGACTACATCTTCCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGT
GCTGTGCTCTACCAGAACACCCGCCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTT
CAAACCCAGACGAGCTCGGTCCAGGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCT
TTCTCTCTTGCCCTCCCCATCCCACCACCTTGGAGCTGTCATAGAGATTGAAACCTTCTAGTAAAATAAATAAAATCTCTGATGGCCATT

>In-frame_ENST00000559240_ENST00000294818_TCGA-GI-A2C8_PBX1_chr1_164532548_+_LRRC52_chr1_165532741_length(amino acids)=194AA_start in transcript=0_stop in transcript=584
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDD
LNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIF

--------------------------------------------------------------
>In-frame_ENST00000367897_ENST00000294818_TCGA-GI-A2C8_PBX1_chr1_164532548_+_LRRC52_chr1_165532741_length(transcript)=722nt_BP=265nt
ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGGATGGGGCC
GGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG
GCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAACAGATGAT
CTAAATGCCACATGTGTGGAGCCCACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCAC
CTGGACCACAAAGACTACATCTTCCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGT
GCTGTGCTCTACCAGAACACCCGCCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTT
CAAACCCAGACGAGCTCGGTCCAGGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCT
TTCTCTCTTGCCCTCCCCATCCCACCACCTTGGAGCTGTCATAGAGATTGAAACCTTCTAGTAAAATAAATAAAATCTCTGATGGCCATT

>In-frame_ENST00000367897_ENST00000294818_TCGA-GI-A2C8_PBX1_chr1_164532548_+_LRRC52_chr1_165532741_length(amino acids)=194AA_start in transcript=0_stop in transcript=584
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDD
LNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIF

--------------------------------------------------------------
>In-frame_ENST00000540236_ENST00000294818_TCGA-GI-A2C8_PBX1_chr1_164532548_+_LRRC52_chr1_165532741_length(transcript)=722nt_BP=265nt
ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGGATGGGGCC
GGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG
GCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAACAGATGAT
CTAAATGCCACATGTGTGGAGCCCACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCAC
CTGGACCACAAAGACTACATCTTCCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGT
GCTGTGCTCTACCAGAACACCCGCCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTT
CAAACCCAGACGAGCTCGGTCCAGGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCT
TTCTCTCTTGCCCTCCCCATCCCACCACCTTGGAGCTGTCATAGAGATTGAAACCTTCTAGTAAAATAAATAAAATCTCTGATGGCCATT

>In-frame_ENST00000540236_ENST00000294818_TCGA-GI-A2C8_PBX1_chr1_164532548_+_LRRC52_chr1_165532741_length(amino acids)=194AA_start in transcript=0_stop in transcript=584
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTDD
LNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIF

--------------------------------------------------------------
>In-frame_ENST00000420696_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165513908_length(transcript)=1157nt_BP=453nt
ATCCTCCCACCATCCTCTAAAGAGGCAAAGGGATTTTTTTTTTCTTTTGGTCTTCTTTTTTCCCCCTTCCCTGTTTATCCTGAAAAGGAT
TTGAAGACAAGCTTGAAGGATAAAAAGCCTTGGTGCTTCCCAGGAGCCGAGCCGAGGAGCAGAAGAGGAAGAGCCGGGGGCTGCCGTAGC
CTTTGGAGATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGG
ATGGGGCCGGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTT
TGGATGAGGCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAA
CAGAACCTGGTGCAGCTGAACATTGCCAACAACCCTCACCTGTTATCGCTTCACAAGTTCACCTTTGCCAACACCACCTCTTTGAGGTAC
CTGGACCTCAGAAATACCGGCTTGCAGACCCTGGACAGTGCTGCCTTATACCACCTCACTACTCTGGAGACCCTGTTTCTGAGTGGAAAC
CCCTGGAAGTGCAACTGCTCTTTCCTGGACTTCGCCATCTTCTTAATAGTGTTCCATATGGACCCCTCAGATGATCTAAATGCCACATGT
GTGGAGCCCACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCACCTGGACCACAAAGAC
TACATCTTCCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGTGCTGTGCTCTACCAG
AACACCCGCCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTTCAAACCCAGACGAGC
TCGGTCCAGGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCTTTCTCTCTTGCCCTC

>In-frame_ENST00000420696_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165513908_length(amino acids)=202AA_start in transcript=411_stop in transcript=1019
MPCLMCCVKSKKKQNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIV
FHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTR

--------------------------------------------------------------
>In-frame_ENST00000401534_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165513908_length(transcript)=969nt_BP=265nt
ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGGATGGGGCC
GGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG
GCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAACAGAACCT
GGTGCAGCTGAACATTGCCAACAACCCTCACCTGTTATCGCTTCACAAGTTCACCTTTGCCAACACCACCTCTTTGAGGTACCTGGACCT
CAGAAATACCGGCTTGCAGACCCTGGACAGTGCTGCCTTATACCACCTCACTACTCTGGAGACCCTGTTTCTGAGTGGAAACCCCTGGAA
GTGCAACTGCTCTTTCCTGGACTTCGCCATCTTCTTAATAGTGTTCCATATGGACCCCTCAGATGATCTAAATGCCACATGTGTGGAGCC
CACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCACCTGGACCACAAAGACTACATCTT
CCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGTGCTGTGCTCTACCAGAACACCCG
CCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTTCAAACCCAGACGAGCTCGGTCCA
GGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCTTTCTCTCTTGCCCTCCCCATCCC

>In-frame_ENST00000401534_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165513908_length(amino acids)=202AA_start in transcript=223_stop in transcript=831
MPCLMCCVKSKKKQNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIV
FHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTR

--------------------------------------------------------------
>In-frame_ENST00000559240_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165513908_length(transcript)=969nt_BP=265nt
ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGGATGGGGCC
GGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG
GCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAACAGAACCT
GGTGCAGCTGAACATTGCCAACAACCCTCACCTGTTATCGCTTCACAAGTTCACCTTTGCCAACACCACCTCTTTGAGGTACCTGGACCT
CAGAAATACCGGCTTGCAGACCCTGGACAGTGCTGCCTTATACCACCTCACTACTCTGGAGACCCTGTTTCTGAGTGGAAACCCCTGGAA
GTGCAACTGCTCTTTCCTGGACTTCGCCATCTTCTTAATAGTGTTCCATATGGACCCCTCAGATGATCTAAATGCCACATGTGTGGAGCC
CACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCACCTGGACCACAAAGACTACATCTT
CCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGTGCTGTGCTCTACCAGAACACCCG
CCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTTCAAACCCAGACGAGCTCGGTCCA
GGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCTTTCTCTCTTGCCCTCCCCATCCC

>In-frame_ENST00000559240_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165513908_length(amino acids)=202AA_start in transcript=223_stop in transcript=831
MPCLMCCVKSKKKQNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIV
FHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTR

--------------------------------------------------------------
>In-frame_ENST00000367897_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165513908_length(transcript)=969nt_BP=265nt
ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGGATGGGGCC
GGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG
GCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAACAGAACCT
GGTGCAGCTGAACATTGCCAACAACCCTCACCTGTTATCGCTTCACAAGTTCACCTTTGCCAACACCACCTCTTTGAGGTACCTGGACCT
CAGAAATACCGGCTTGCAGACCCTGGACAGTGCTGCCTTATACCACCTCACTACTCTGGAGACCCTGTTTCTGAGTGGAAACCCCTGGAA
GTGCAACTGCTCTTTCCTGGACTTCGCCATCTTCTTAATAGTGTTCCATATGGACCCCTCAGATGATCTAAATGCCACATGTGTGGAGCC
CACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCACCTGGACCACAAAGACTACATCTT
CCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGTGCTGTGCTCTACCAGAACACCCG
CCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTTCAAACCCAGACGAGCTCGGTCCA
GGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCTTTCTCTCTTGCCCTCCCCATCCC

>In-frame_ENST00000367897_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165513908_length(amino acids)=202AA_start in transcript=223_stop in transcript=831
MPCLMCCVKSKKKQNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIV
FHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTR

--------------------------------------------------------------
>In-frame_ENST00000540236_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165513908_length(transcript)=969nt_BP=265nt
ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCCGGCCTGTCCCAGCACTTGCAGGATGGGGCC
GGAGGGACCGAGGGGGAGGGCGGGAGGAAGCAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG
GCGCAGGCCAGAAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTGTTGTGTGAAATCAAAGAAAAAACAGAACCT
GGTGCAGCTGAACATTGCCAACAACCCTCACCTGTTATCGCTTCACAAGTTCACCTTTGCCAACACCACCTCTTTGAGGTACCTGGACCT
CAGAAATACCGGCTTGCAGACCCTGGACAGTGCTGCCTTATACCACCTCACTACTCTGGAGACCCTGTTTCTGAGTGGAAACCCCTGGAA
GTGCAACTGCTCTTTCCTGGACTTCGCCATCTTCTTAATAGTGTTCCATATGGACCCCTCAGATGATCTAAATGCCACATGTGTGGAGCC
CACAGAGCTGACAGGGTGGCCCATCACCCGGGTGGGGAACCCACTCCGATACATGTGCATCACGCACCTGGACCACAAAGACTACATCTT
CCTGCTGCTCATCGGCTTCTGCATCTTCGCCGCGGGAACTGTGGCTGCCTGGCTCACAGGTGTGTGTGCTGTGCTCTACCAGAACACCCG
CCACAAGTCGAGTGAAGAAGATGAGGACGAGGCCGGGACTAGGGTGGAAGTCAGCCGGCGGATTTTTCAAACCCAGACGAGCTCGGTCCA
GGAGTTCCCTCAGCTTATTTAGTTGCCAGAGACCACTATCTTATGTGCCTCCCCCAGGCTCCCTGCTTTCTCTCTTGCCCTCCCCATCCC

>In-frame_ENST00000540236_ENST00000294818_TCGA-GI-A2C8-01A_PBX1_chr1_164532548_+_LRRC52_chr1_165513908_length(amino acids)=202AA_start in transcript=223_stop in transcript=831
MPCLMCCVKSKKKQNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIV
FHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PBX1-LRRC52


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PBX1-LRRC52


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PBX1-LRRC52


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePBX1C0006413Burkitt Lymphoma2CTD_human;ORPHANET
HgenePBX1C0343640African Burkitt's lymphoma2CTD_human
HgenePBX1C1968949Cakut2GENOMICS_ENGLAND
HgenePBX1C4721444Burkitt Leukemia2CTD_human
HgenePBX1C0013146Drug abuse1CTD_human
HgenePBX1C0013170Drug habituation1CTD_human
HgenePBX1C0013222Drug Use Disorders1CTD_human
HgenePBX1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgenePBX1C0038580Substance Dependence1CTD_human
HgenePBX1C0038586Substance Use Disorders1CTD_human
HgenePBX1C0236969Substance-Related Disorders1CTD_human
HgenePBX1C0431692Bilateral renal hypoplasia1ORPHANET
HgenePBX1C0740858Substance abuse problem1CTD_human
HgenePBX1C1510472Drug Dependence1CTD_human
HgenePBX1C4316881Prescription Drug Abuse1CTD_human
HgenePBX1C4539968CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT SYNDROME WITH OR WITHOUT HEARING LOSS, ABNORMAL EARS, OR DEVELOPMENTAL DELAY1GENOMICS_ENGLAND