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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF10-ADGB (FusionGDB2 ID:6287)

Fusion Gene Summary for ARHGEF10-ADGB

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF10-ADGB
Fusion gene ID: 6287
HgeneTgene
Gene symbol

ARHGEF10

ADGB

Gene ID

9639

79747

Gene nameRho guanine nucleotide exchange factor 10androglobin
SynonymsGEF10|SNCVC6orf103|CAPN16
Cytomap

8p23.3

6q24.3

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 10Rho guanine nucleotide exchange factor (GEF) 10androglobincalpain-7-like protein
Modification date2020031320200313
UniProtAcc

O15013

Q8N7X0

Ensembl transtripts involved in fusion geneENST00000349830, ENST00000520359, 
ENST00000398560, ENST00000518288, 
ENST00000398564, ENST00000262112, 
ENST00000521927, 		ENST00000397944, 
ENST00000367493, ENST00000523560, 
ENST00000367488, 
Fusion gene scores* DoF score5 X 5 X 5=1259 X 8 X 5=360
# samples 59
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF10 [Title/Abstract] AND ADGB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF10(1791602)-ADGB(147022077), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGEF10-ADGB seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF10

GO:0090630

activation of GTPase activity

16896804


check buttonFusion gene breakpoints across ARHGEF10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ADGB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-3H-AB3S-01AARHGEF10chr8

1791602

+ADGBchr6

147022077

+


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Fusion Gene ORF analysis for ARHGEF10-ADGB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000349830ENST00000397944ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-5UTRENST00000349830ENST00000367493ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-intronENST00000349830ENST00000523560ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-intronENST00000349830ENST00000367488ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
Frame-shiftENST00000520359ENST00000397944ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-5UTRENST00000520359ENST00000367493ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-intronENST00000520359ENST00000523560ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-intronENST00000520359ENST00000367488ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
Frame-shiftENST00000398560ENST00000397944ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-5UTRENST00000398560ENST00000367493ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-intronENST00000398560ENST00000523560ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-intronENST00000398560ENST00000367488ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
Frame-shiftENST00000518288ENST00000397944ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-5UTRENST00000518288ENST00000367493ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-intronENST00000518288ENST00000523560ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-intronENST00000518288ENST00000367488ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
Frame-shiftENST00000398564ENST00000397944ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-5UTRENST00000398564ENST00000367493ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-intronENST00000398564ENST00000523560ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-intronENST00000398564ENST00000367488ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
Frame-shiftENST00000262112ENST00000397944ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-5UTRENST00000262112ENST00000367493ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-intronENST00000262112ENST00000523560ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
5CDS-intronENST00000262112ENST00000367488ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
intron-3CDSENST00000521927ENST00000397944ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
intron-5UTRENST00000521927ENST00000367493ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
intron-intronENST00000521927ENST00000523560ARHGEF10chr8

1791602

+ADGBchr6

147022077

+
intron-intronENST00000521927ENST00000367488ARHGEF10chr8

1791602

+ADGBchr6

147022077

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARHGEF10-ADGB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGEF10chr81791602+ADGBchr6147022076+0.0002887230.9997112
ARHGEF10chr81791602+ADGBchr6147022076+0.0002887230.9997112

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGEF10-ADGB


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF10

O15013

ADGB

Q8N7X0

FUNCTION: May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARHGEF10-ADGB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARHGEF10-ADGB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF10-ADGB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF10-ADGB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGEF10C0005586Bipolar Disorder1PSYGENET
HgeneARHGEF10C0011570Mental Depression1PSYGENET
HgeneARHGEF10C0011581Depressive disorder1PSYGENET
HgeneARHGEF10C1842357Slowed Nerve Conduction Velocity, Autosomal Dominant1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT