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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PCNX-TTC19 (FusionGDB2 ID:63036)

Fusion Gene Summary for PCNX-TTC19

check button Fusion gene summary
Fusion gene informationFusion gene name: PCNX-TTC19
Fusion gene ID: 63036
HgeneTgene
Gene symbol

PCNX

TTC19

Gene ID

22990

54902

Gene namepecanex 1tetratricopeptide repeat domain 19
SynonymsPCNX|PCNXL1|pecanex2010204O13Rik|MC3DN2
Cytomap

14q24.2

17p12

Type of geneprotein-codingprotein-coding
Descriptionpecanex-like protein 1pecanex homolog 1tetratricopeptide repeat protein 19, mitochondrialTPR repeat protein 19
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000238570, ENST00000304743, 
ENST00000439984, ENST00000556272, 
ENST00000261647, ENST00000486880, 
ENST00000497842, 
Fusion gene scores* DoF score5 X 3 X 5=7510 X 9 X 5=450
# samples 510
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCNX [Title/Abstract] AND TTC19 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPCNX(71435827)-TTC19(15928330), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PCNX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TTC19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-2095PCNXchr14

71435827

+TTC19chr17

15928330

+


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Fusion Gene ORF analysis for PCNX-TTC19

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000238570ENST00000261647PCNXchr14

71435827

+TTC19chr17

15928330

+
In-frameENST00000238570ENST00000486880PCNXchr14

71435827

+TTC19chr17

15928330

+
5CDS-3UTRENST00000238570ENST00000497842PCNXchr14

71435827

+TTC19chr17

15928330

+
In-frameENST00000304743ENST00000261647PCNXchr14

71435827

+TTC19chr17

15928330

+
In-frameENST00000304743ENST00000486880PCNXchr14

71435827

+TTC19chr17

15928330

+
5CDS-3UTRENST00000304743ENST00000497842PCNXchr14

71435827

+TTC19chr17

15928330

+
In-frameENST00000439984ENST00000261647PCNXchr14

71435827

+TTC19chr17

15928330

+
In-frameENST00000439984ENST00000486880PCNXchr14

71435827

+TTC19chr17

15928330

+
5CDS-3UTRENST00000439984ENST00000497842PCNXchr14

71435827

+TTC19chr17

15928330

+
intron-3CDSENST00000556272ENST00000261647PCNXchr14

71435827

+TTC19chr17

15928330

+
intron-3CDSENST00000556272ENST00000486880PCNXchr14

71435827

+TTC19chr17

15928330

+
intron-3UTRENST00000556272ENST00000497842PCNXchr14

71435827

+TTC19chr17

15928330

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000238570PCNXchr1471435827+ENST00000261647TTC19chr1715928330+290710503591516385
ENST00000238570PCNXchr1471435827+ENST00000486880TTC19chr1715928330+277710503591516385
ENST00000304743PCNXchr1471435827+ENST00000261647TTC19chr1715928330+290710503591516385
ENST00000304743PCNXchr1471435827+ENST00000486880TTC19chr1715928330+277710503591516385
ENST00000439984PCNXchr1471435827+ENST00000261647TTC19chr1715928330+2573716251182385
ENST00000439984PCNXchr1471435827+ENST00000486880TTC19chr1715928330+2443716251182385

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000238570ENST00000261647PCNXchr1471435827+TTC19chr1715928330+0.0015591850.9984408
ENST00000238570ENST00000486880PCNXchr1471435827+TTC19chr1715928330+0.0019639020.9980361
ENST00000304743ENST00000261647PCNXchr1471435827+TTC19chr1715928330+0.0015591850.9984408
ENST00000304743ENST00000486880PCNXchr1471435827+TTC19chr1715928330+0.0019639020.9980361
ENST00000439984ENST00000261647PCNXchr1471435827+TTC19chr1715928330+0.0009059980.999094
ENST00000439984ENST00000486880PCNXchr1471435827+TTC19chr1715928330+0.0010096360.99899036

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Fusion Genomic Features for PCNX-TTC19


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PCNXchr1471435827+TTC19chr1715928330+1.39E-050.9999862
PCNXchr1471435827+TTC19chr1715928330+1.39E-050.9999862

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PCNX-TTC19


check button Go to

FGviewer for the breakpoints of chr14:71435827-chr17:15928330

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+53528_50201.333333333333342270.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+53557_74201.333333333333342270.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+53628_50201.333333333333342342.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+53657_74201.333333333333342342.0TransmembraneHelical
TgeneTTC19chr14:71435827chr17:15928330ENST00000261647610237_270225.33333333333334381.0RepeatNote=TPR 3
TgeneTTC19chr14:71435827chr17:15928330ENST00000261647610279_312225.33333333333334381.0RepeatNote=TPR 4
TgeneTTC19chr14:71435827chr17:15928330ENST00000261647610318_351225.33333333333334381.0RepeatNote=TPR 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+5352103_2199201.333333333333342270.0Compositional biasNote=Ser-rich
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+535245_250201.333333333333342270.0Compositional biasNote=Poly-His
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+535602_635201.333333333333342270.0Compositional biasNote=Ser-rich
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+5362103_2199201.333333333333342342.0Compositional biasNote=Ser-rich
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+536245_250201.333333333333342342.0Compositional biasNote=Poly-His
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+536602_635201.333333333333342342.0Compositional biasNote=Ser-rich
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+5351003_1025201.333333333333342270.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+5351032_1049201.333333333333342270.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+5351067_1089201.333333333333342270.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+5351110_1132201.333333333333342270.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+5351160_1182201.333333333333342270.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+5351194_1213201.333333333333342270.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+5351266_1288201.333333333333342270.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000238570+5351295_1312201.333333333333342270.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+5361003_1025201.333333333333342342.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+5361032_1049201.333333333333342342.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+5361067_1089201.333333333333342342.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+5361110_1132201.333333333333342342.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+5361160_1182201.333333333333342342.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+5361194_1213201.333333333333342342.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+5361266_1288201.333333333333342342.0TransmembraneHelical
HgenePCNXchr14:71435827chr17:15928330ENST00000304743+5361295_1312201.333333333333342342.0TransmembraneHelical
TgeneTTC19chr14:71435827chr17:15928330ENST0000026164761073_76225.33333333333334381.0Compositional biasNote=Poly-Glu
TgeneTTC19chr14:71435827chr17:15928330ENST0000048688061073_76346.3333333333333502.0Compositional biasNote=Poly-Glu
TgeneTTC19chr14:71435827chr17:15928330ENST00000261647610136_169225.33333333333334381.0RepeatNote=TPR 1
TgeneTTC19chr14:71435827chr17:15928330ENST00000261647610179_212225.33333333333334381.0RepeatNote=TPR 2
TgeneTTC19chr14:71435827chr17:15928330ENST00000486880610136_169346.3333333333333502.0RepeatNote=TPR 1
TgeneTTC19chr14:71435827chr17:15928330ENST00000486880610179_212346.3333333333333502.0RepeatNote=TPR 2
TgeneTTC19chr14:71435827chr17:15928330ENST00000486880610237_270346.3333333333333502.0RepeatNote=TPR 3
TgeneTTC19chr14:71435827chr17:15928330ENST00000486880610279_312346.3333333333333502.0RepeatNote=TPR 4
TgeneTTC19chr14:71435827chr17:15928330ENST00000486880610318_351346.3333333333333502.0RepeatNote=TPR 5


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Fusion Gene Sequence for PCNX-TTC19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000238570_ENST00000261647_TCGA-61-2095_PCNX_chr14_71435827_+_TTC19_chr17_15928330_length(transcript)=2907nt_BP=1050nt
GAGGAGGAGCTGGAGGGGGCGCGGCTTCCTCTCGGTCGCTCCCTGGCGCCGGGCCTCTTTCTCTGCCTGGCCCAGGGCTGGCGGCCGGCG
GGGGTCGCGGCGGCGGCAGTGGGGGCGCTGGCGGGCCGCGGGTGGCGGGGGCCGGGCCGCGGCTCCGGGTGTTAGGAGACAAGATGGCGG
CGGCTCTCAGAAGGCCGGTCTCCTCCTCTCCGCCGTCCTCCGCCCCGCCGCTCGCCGCCTCCTCCTCTCGGGTCTCCTCCTCCTCGTTTG
CTGCCTCCTCCTCCTCCTGCAGCAGCACCAGCGACCGCCGAAGCGCCGGCTCGCTCACCCGGAGCTCCGGAGGTGGATAGACGGGGCAGC
TGCAGGCTCCGGCGACCGAGGCCGAGCTGGGGCCGGGGCGGGGACGGCGGCGGCGGCGGCGGCGACGGCGGCGGCGCCGGGTGGGGATGG
GGTCGCAGACGCTGCAGATCCTCCGACAGGGGGTGTGGGCCGCGCTCAGCGGGGGCTGGTACTACGACCCGCACCAGGCCACCTTCGTGA
ACGCGCTGCACCTCTACCTGTGGCTCTTTCTGCTGGGCCTGCCCTTCACCCTCTACATGGCCCTTCCTTCTACCATGATTATAGTAGCAG
TTTATTGTCCTGTGATAGCTGCTGTTTTCATTGTTCTGAAGATGGTCAACTATCGACTACACAGAGCACTTGATGCTGGAGAAGTTGTAG
ATAGGACTGCAAATGAGTTCACGGATCAGCGAACCAAAGCTGAACAAGGCAACTGTTCAACCAGGAGAAAAGACAGCAATGGACCGAGTG
ATCCTGGTGGAGGGATTGAAATGTCTGAGTTCATCCGAGAGGCCACACCCCCAGTTGGTTGCAGTTCCAGAAATTCTTATGCCGGTCTAG
ATCCAAGCAACCAGATTGGATCTGGTTCCTCGCGTCTTGGAACAGCAGCAACTATTAAAGGAGATACAGACACTGCTAAGACTTCTGATG
ATATCAGTTTAAGTCTGGGCCAAAGTTCTAGTCTTTGTAAGGAAGGAAGTGAAGAACAAGTGGAAGAGAAAGCCAATACCCACCTCCTCT
TGGGCATGTGCTTAGACGCCTGTGCTCGCTACCTTCTGTTCTCCAAGCAGCCGTCACAGGCACAAAGGATGTATGAAAAAGCTCTGCAGA
TTTCTGAAGAAATACAAGGAGAAAGACACCCACAGACCATTGTGCTGATGAGTGACCTGGCTACTACCCTGGATGCACAGGGCCGCTTTG
ATGAGGCCTATATTTATATGCAAAGGGCATCAGATCTGGCAAGACAGATAAATCATCCTGAGCTACACATGGTACTCAGTAATCTAGCTG
CAGTTTTGATGCACAGAGAACGATATACACAAGCAAAAGAGATCTACCAGGAAGCACTGAAGCAAGCAAAGCTGAAAAAAGATGAAATTT
CTGTACAACACATCAGGGAAGAGTTGGCTGAGCTGTCAAAGAAAAGTAGACCTTTGACAAATTCTGTCAAGCTCTAAATCCATTTTTGTG
TAGGGAGAATAATGTCTAGTAATGTGGAAGAATAGCTATCATTCCTGTCTCTGTGGCACCCGATCAATGGCTTAAATCTGTCGTTTTTGA
TATTCAGGTTTCCTCAATTTAGCCTTAGTGAAGGAGGGGTTGTACACACTGCCATTTTTGTATTTTAAAGGAAAAATGACTTTCATTCCC
AACTGATTATGACCTTTCAGGATGTCGTCAAGTGATGCTTTCAGTTGTAACACGTGACTTGGTGCTGTCCCTGCTGGTCTAAGTAGAACT
GTAGATTCATATGGGCTGGTGTTCCTGTGCGCTGTGGGTGTGGTGATTCAGCCTGGCATTTCTACCATAAGTTTTTGGTCTGCTGATTTG
CTGCCCTGTCTTCTCTTACTTTACTTTATCAATACCTGGCAAACTGACCAGAATTACCTTCCTCATGGCAAAGGGGGATTATGGTGAATT
GTTGTTCTTATAGTCTGTTTCATGAAGCACAAGTGGAATTTAATACATAAAAGAGAAAAATATCTTAGTTTGCTACCAGCATCCAGCATG
AAGTTGTAAAGTGGGGATTAGGCACGTGACAGTATAGCACCCATTTGAATTTAAATAAAAGTGAACCATATTTATCTGGTTATATAAAAC
TAAAAATGGGGGTGTTTATATAAAACTAAAAACTAAGAATGATGTAACCTTTTGTCTGTGTTATCTGAACACTCTACTTCCTTTGCAGCC
TTAGTCACACAACTGAGTCATCTCAAGTACTCTTTAAGGACACACAGCCCAGGCTGTTCTGAGTCAGAATAGGCCCCTACAGGTATATTT
TAAAACTCTTCGTAATTCTAATGTGTACTGCTGGTATAGCTGAACTACTGACCTGGATCTTAGTCCTAGCCTTTTTGCTTTTGCAATTTC
AGTATCTTCATCTCTAAACTAGGGAAACACTGGGATTCTTTCTTAGCTGTGGGGGAAGGTATTTGGTTAGATGACTTTGAATGAATAGAC
TGCTGTGCTGAAAGAGCTTTATCACACTGTCTCAAAGTATGTAAAGATACATAGGTGGATGCTCTTACTGCAGCAGTCATGAATACATTT
TTAGCCATTTACCTAAGGAAAAAGACAGTTTTTCTAGGTACCATGAAGGAAGATTGACCCTGTTGGTATGCCTGTGGGGGTGGGATGTGA
GTGGGACTGATAAACTGATACTTTTGGTTCGTATGTACATACTGGAAGAATCTTCATAATAAATGAGACTACACAACAATATTGTATGTA
TCCCAGTAATCTTTGCATTTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAACTTTCTGAAGAAAATAAAAACACCAGAAACCTTGAGGTC

>In-frame_ENST00000238570_ENST00000261647_TCGA-61-2095_PCNX_chr14_71435827_+_TTC19_chr17_15928330_length(amino acids)=385AA_start in transcript=359_stop in transcript=1516
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMALPSTMIIVA
VYCPVIAAVFIVLKMVNYRLHRALDAGEVVDRTANEFTDQRTKAEQGNCSTRRKDSNGPSDPGGGIEMSEFIREATPPVGCSSRNSYAGL
DPSNQIGSGSSRLGTAATIKGDTDTAKTSDDISLSLGQSSSLCKEGSEEQVEEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQ
ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKLKKDEI

--------------------------------------------------------------
>In-frame_ENST00000238570_ENST00000486880_TCGA-61-2095_PCNX_chr14_71435827_+_TTC19_chr17_15928330_length(transcript)=2777nt_BP=1050nt
GAGGAGGAGCTGGAGGGGGCGCGGCTTCCTCTCGGTCGCTCCCTGGCGCCGGGCCTCTTTCTCTGCCTGGCCCAGGGCTGGCGGCCGGCG
GGGGTCGCGGCGGCGGCAGTGGGGGCGCTGGCGGGCCGCGGGTGGCGGGGGCCGGGCCGCGGCTCCGGGTGTTAGGAGACAAGATGGCGG
CGGCTCTCAGAAGGCCGGTCTCCTCCTCTCCGCCGTCCTCCGCCCCGCCGCTCGCCGCCTCCTCCTCTCGGGTCTCCTCCTCCTCGTTTG
CTGCCTCCTCCTCCTCCTGCAGCAGCACCAGCGACCGCCGAAGCGCCGGCTCGCTCACCCGGAGCTCCGGAGGTGGATAGACGGGGCAGC
TGCAGGCTCCGGCGACCGAGGCCGAGCTGGGGCCGGGGCGGGGACGGCGGCGGCGGCGGCGGCGACGGCGGCGGCGCCGGGTGGGGATGG
GGTCGCAGACGCTGCAGATCCTCCGACAGGGGGTGTGGGCCGCGCTCAGCGGGGGCTGGTACTACGACCCGCACCAGGCCACCTTCGTGA
ACGCGCTGCACCTCTACCTGTGGCTCTTTCTGCTGGGCCTGCCCTTCACCCTCTACATGGCCCTTCCTTCTACCATGATTATAGTAGCAG
TTTATTGTCCTGTGATAGCTGCTGTTTTCATTGTTCTGAAGATGGTCAACTATCGACTACACAGAGCACTTGATGCTGGAGAAGTTGTAG
ATAGGACTGCAAATGAGTTCACGGATCAGCGAACCAAAGCTGAACAAGGCAACTGTTCAACCAGGAGAAAAGACAGCAATGGACCGAGTG
ATCCTGGTGGAGGGATTGAAATGTCTGAGTTCATCCGAGAGGCCACACCCCCAGTTGGTTGCAGTTCCAGAAATTCTTATGCCGGTCTAG
ATCCAAGCAACCAGATTGGATCTGGTTCCTCGCGTCTTGGAACAGCAGCAACTATTAAAGGAGATACAGACACTGCTAAGACTTCTGATG
ATATCAGTTTAAGTCTGGGCCAAAGTTCTAGTCTTTGTAAGGAAGGAAGTGAAGAACAAGTGGAAGAGAAAGCCAATACCCACCTCCTCT
TGGGCATGTGCTTAGACGCCTGTGCTCGCTACCTTCTGTTCTCCAAGCAGCCGTCACAGGCACAAAGGATGTATGAAAAAGCTCTGCAGA
TTTCTGAAGAAATACAAGGAGAAAGACACCCACAGACCATTGTGCTGATGAGTGACCTGGCTACTACCCTGGATGCACAGGGCCGCTTTG
ATGAGGCCTATATTTATATGCAAAGGGCATCAGATCTGGCAAGACAGATAAATCATCCTGAGCTACACATGGTACTCAGTAATCTAGCTG
CAGTTTTGATGCACAGAGAACGATATACACAAGCAAAAGAGATCTACCAGGAAGCACTGAAGCAAGCAAAGCTGAAAAAAGATGAAATTT
CTGTACAACACATCAGGGAAGAGTTGGCTGAGCTGTCAAAGAAAAGTAGACCTTTGACAAATTCTGTCAAGCTCTAAATCCATTTTTGTG
TAGGGAGAATAATGTCTAGTAATGTGGAAGAATAGCTATCATTCCTGTCTCTGTGGCACCCGATCAATGGCTTAAATCTGTCGTTTTTGA
TATTCAGGTTTCCTCAATTTAGCCTTAGTGAAGGAGGGGTTGTACACACTGCCATTTTTGTATTTTAAAGGAAAAATGACTTTCATTCCC
AACTGATTATGACCTTTCAGGATGTCGTCAAGTGATGCTTTCAGTTGTAACACGTGACTTGGTGCTGTCCCTGCTGGTCTAAGTAGAACT
GTAGATTCATATGGGCTGGTGTTCCTGTGCGCTGTGGGTGTGGTGATTCAGCCTGGCATTTCTACCATAAGTTTTTGGTCTGCTGATTTG
CTGCCCTGTCTTCTCTTACTTTACTTTATCAATACCTGGCAAACTGACCAGAATTACCTTCCTCATGGCAAAGGGGGATTATGGTGAATT
GTTGTTCTTATAGTCTGTTTCATGAAGCACAAGTGGAATTTAATACATAAAAGAGAAAAATATCTTAGTTTGCTACCAGCATCCAGCATG
AAGTTGTAAAGTGGGGATTAGGCACGTGACAGTATAGCACCCATTTGAATTTAAATAAAAGTGAACCATATTTATCTGGTTATATAAAAC
TAAAAATGGGGGTGTTTATATAAAACTAAAAACTAAGAATGATGTAACCTTTTGTCTGTGTTATCTGAACACTCTACTTCCTTTGCAGCC
TTAGTCACACAACTGAGTCATCTCAAGTACTCTTTAAGGACACACAGCCCAGGCTGTTCTGAGTCAGAATAGGCCCCTACAGGTATATTT
TAAAACTCTTCGTAATTCTAATGTGTACTGCTGGTATAGCTGAACTACTGACCTGGATCTTAGTCCTAGCCTTTTTGCTTTTGCAATTTC
AGTATCTTCATCTCTAAACTAGGGAAACACTGGGATTCTTTCTTAGCTGTGGGGGAAGGTATTTGGTTAGATGACTTTGAATGAATAGAC
TGCTGTGCTGAAAGAGCTTTATCACACTGTCTCAAAGTATGTAAAGATACATAGGTGGATGCTCTTACTGCAGCAGTCATGAATACATTT
TTAGCCATTTACCTAAGGAAAAAGACAGTTTTTCTAGGTACCATGAAGGAAGATTGACCCTGTTGGTATGCCTGTGGGGGTGGGATGTGA

>In-frame_ENST00000238570_ENST00000486880_TCGA-61-2095_PCNX_chr14_71435827_+_TTC19_chr17_15928330_length(amino acids)=385AA_start in transcript=359_stop in transcript=1516
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMALPSTMIIVA
VYCPVIAAVFIVLKMVNYRLHRALDAGEVVDRTANEFTDQRTKAEQGNCSTRRKDSNGPSDPGGGIEMSEFIREATPPVGCSSRNSYAGL
DPSNQIGSGSSRLGTAATIKGDTDTAKTSDDISLSLGQSSSLCKEGSEEQVEEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQ
ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKLKKDEI

--------------------------------------------------------------
>In-frame_ENST00000304743_ENST00000261647_TCGA-61-2095_PCNX_chr14_71435827_+_TTC19_chr17_15928330_length(transcript)=2907nt_BP=1050nt
GAGGAGGAGCTGGAGGGGGCGCGGCTTCCTCTCGGTCGCTCCCTGGCGCCGGGCCTCTTTCTCTGCCTGGCCCAGGGCTGGCGGCCGGCG
GGGGTCGCGGCGGCGGCAGTGGGGGCGCTGGCGGGCCGCGGGTGGCGGGGGCCGGGCCGCGGCTCCGGGTGTTAGGAGACAAGATGGCGG
CGGCTCTCAGAAGGCCGGTCTCCTCCTCTCCGCCGTCCTCCGCCCCGCCGCTCGCCGCCTCCTCCTCTCGGGTCTCCTCCTCCTCGTTTG
CTGCCTCCTCCTCCTCCTGCAGCAGCACCAGCGACCGCCGAAGCGCCGGCTCGCTCACCCGGAGCTCCGGAGGTGGATAGACGGGGCAGC
TGCAGGCTCCGGCGACCGAGGCCGAGCTGGGGCCGGGGCGGGGACGGCGGCGGCGGCGGCGGCGACGGCGGCGGCGCCGGGTGGGGATGG
GGTCGCAGACGCTGCAGATCCTCCGACAGGGGGTGTGGGCCGCGCTCAGCGGGGGCTGGTACTACGACCCGCACCAGGCCACCTTCGTGA
ACGCGCTGCACCTCTACCTGTGGCTCTTTCTGCTGGGCCTGCCCTTCACCCTCTACATGGCCCTTCCTTCTACCATGATTATAGTAGCAG
TTTATTGTCCTGTGATAGCTGCTGTTTTCATTGTTCTGAAGATGGTCAACTATCGACTACACAGAGCACTTGATGCTGGAGAAGTTGTAG
ATAGGACTGCAAATGAGTTCACGGATCAGCGAACCAAAGCTGAACAAGGCAACTGTTCAACCAGGAGAAAAGACAGCAATGGACCGAGTG
ATCCTGGTGGAGGGATTGAAATGTCTGAGTTCATCCGAGAGGCCACACCCCCAGTTGGTTGCAGTTCCAGAAATTCTTATGCCGGTCTAG
ATCCAAGCAACCAGATTGGATCTGGTTCCTCGCGTCTTGGAACAGCAGCAACTATTAAAGGAGATACAGACACTGCTAAGACTTCTGATG
ATATCAGTTTAAGTCTGGGCCAAAGTTCTAGTCTTTGTAAGGAAGGAAGTGAAGAACAAGTGGAAGAGAAAGCCAATACCCACCTCCTCT
TGGGCATGTGCTTAGACGCCTGTGCTCGCTACCTTCTGTTCTCCAAGCAGCCGTCACAGGCACAAAGGATGTATGAAAAAGCTCTGCAGA
TTTCTGAAGAAATACAAGGAGAAAGACACCCACAGACCATTGTGCTGATGAGTGACCTGGCTACTACCCTGGATGCACAGGGCCGCTTTG
ATGAGGCCTATATTTATATGCAAAGGGCATCAGATCTGGCAAGACAGATAAATCATCCTGAGCTACACATGGTACTCAGTAATCTAGCTG
CAGTTTTGATGCACAGAGAACGATATACACAAGCAAAAGAGATCTACCAGGAAGCACTGAAGCAAGCAAAGCTGAAAAAAGATGAAATTT
CTGTACAACACATCAGGGAAGAGTTGGCTGAGCTGTCAAAGAAAAGTAGACCTTTGACAAATTCTGTCAAGCTCTAAATCCATTTTTGTG
TAGGGAGAATAATGTCTAGTAATGTGGAAGAATAGCTATCATTCCTGTCTCTGTGGCACCCGATCAATGGCTTAAATCTGTCGTTTTTGA
TATTCAGGTTTCCTCAATTTAGCCTTAGTGAAGGAGGGGTTGTACACACTGCCATTTTTGTATTTTAAAGGAAAAATGACTTTCATTCCC
AACTGATTATGACCTTTCAGGATGTCGTCAAGTGATGCTTTCAGTTGTAACACGTGACTTGGTGCTGTCCCTGCTGGTCTAAGTAGAACT
GTAGATTCATATGGGCTGGTGTTCCTGTGCGCTGTGGGTGTGGTGATTCAGCCTGGCATTTCTACCATAAGTTTTTGGTCTGCTGATTTG
CTGCCCTGTCTTCTCTTACTTTACTTTATCAATACCTGGCAAACTGACCAGAATTACCTTCCTCATGGCAAAGGGGGATTATGGTGAATT
GTTGTTCTTATAGTCTGTTTCATGAAGCACAAGTGGAATTTAATACATAAAAGAGAAAAATATCTTAGTTTGCTACCAGCATCCAGCATG
AAGTTGTAAAGTGGGGATTAGGCACGTGACAGTATAGCACCCATTTGAATTTAAATAAAAGTGAACCATATTTATCTGGTTATATAAAAC
TAAAAATGGGGGTGTTTATATAAAACTAAAAACTAAGAATGATGTAACCTTTTGTCTGTGTTATCTGAACACTCTACTTCCTTTGCAGCC
TTAGTCACACAACTGAGTCATCTCAAGTACTCTTTAAGGACACACAGCCCAGGCTGTTCTGAGTCAGAATAGGCCCCTACAGGTATATTT
TAAAACTCTTCGTAATTCTAATGTGTACTGCTGGTATAGCTGAACTACTGACCTGGATCTTAGTCCTAGCCTTTTTGCTTTTGCAATTTC
AGTATCTTCATCTCTAAACTAGGGAAACACTGGGATTCTTTCTTAGCTGTGGGGGAAGGTATTTGGTTAGATGACTTTGAATGAATAGAC
TGCTGTGCTGAAAGAGCTTTATCACACTGTCTCAAAGTATGTAAAGATACATAGGTGGATGCTCTTACTGCAGCAGTCATGAATACATTT
TTAGCCATTTACCTAAGGAAAAAGACAGTTTTTCTAGGTACCATGAAGGAAGATTGACCCTGTTGGTATGCCTGTGGGGGTGGGATGTGA
GTGGGACTGATAAACTGATACTTTTGGTTCGTATGTACATACTGGAAGAATCTTCATAATAAATGAGACTACACAACAATATTGTATGTA
TCCCAGTAATCTTTGCATTTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAACTTTCTGAAGAAAATAAAAACACCAGAAACCTTGAGGTC

>In-frame_ENST00000304743_ENST00000261647_TCGA-61-2095_PCNX_chr14_71435827_+_TTC19_chr17_15928330_length(amino acids)=385AA_start in transcript=359_stop in transcript=1516
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMALPSTMIIVA
VYCPVIAAVFIVLKMVNYRLHRALDAGEVVDRTANEFTDQRTKAEQGNCSTRRKDSNGPSDPGGGIEMSEFIREATPPVGCSSRNSYAGL
DPSNQIGSGSSRLGTAATIKGDTDTAKTSDDISLSLGQSSSLCKEGSEEQVEEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQ
ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKLKKDEI

--------------------------------------------------------------
>In-frame_ENST00000304743_ENST00000486880_TCGA-61-2095_PCNX_chr14_71435827_+_TTC19_chr17_15928330_length(transcript)=2777nt_BP=1050nt
GAGGAGGAGCTGGAGGGGGCGCGGCTTCCTCTCGGTCGCTCCCTGGCGCCGGGCCTCTTTCTCTGCCTGGCCCAGGGCTGGCGGCCGGCG
GGGGTCGCGGCGGCGGCAGTGGGGGCGCTGGCGGGCCGCGGGTGGCGGGGGCCGGGCCGCGGCTCCGGGTGTTAGGAGACAAGATGGCGG
CGGCTCTCAGAAGGCCGGTCTCCTCCTCTCCGCCGTCCTCCGCCCCGCCGCTCGCCGCCTCCTCCTCTCGGGTCTCCTCCTCCTCGTTTG
CTGCCTCCTCCTCCTCCTGCAGCAGCACCAGCGACCGCCGAAGCGCCGGCTCGCTCACCCGGAGCTCCGGAGGTGGATAGACGGGGCAGC
TGCAGGCTCCGGCGACCGAGGCCGAGCTGGGGCCGGGGCGGGGACGGCGGCGGCGGCGGCGGCGACGGCGGCGGCGCCGGGTGGGGATGG
GGTCGCAGACGCTGCAGATCCTCCGACAGGGGGTGTGGGCCGCGCTCAGCGGGGGCTGGTACTACGACCCGCACCAGGCCACCTTCGTGA
ACGCGCTGCACCTCTACCTGTGGCTCTTTCTGCTGGGCCTGCCCTTCACCCTCTACATGGCCCTTCCTTCTACCATGATTATAGTAGCAG
TTTATTGTCCTGTGATAGCTGCTGTTTTCATTGTTCTGAAGATGGTCAACTATCGACTACACAGAGCACTTGATGCTGGAGAAGTTGTAG
ATAGGACTGCAAATGAGTTCACGGATCAGCGAACCAAAGCTGAACAAGGCAACTGTTCAACCAGGAGAAAAGACAGCAATGGACCGAGTG
ATCCTGGTGGAGGGATTGAAATGTCTGAGTTCATCCGAGAGGCCACACCCCCAGTTGGTTGCAGTTCCAGAAATTCTTATGCCGGTCTAG
ATCCAAGCAACCAGATTGGATCTGGTTCCTCGCGTCTTGGAACAGCAGCAACTATTAAAGGAGATACAGACACTGCTAAGACTTCTGATG
ATATCAGTTTAAGTCTGGGCCAAAGTTCTAGTCTTTGTAAGGAAGGAAGTGAAGAACAAGTGGAAGAGAAAGCCAATACCCACCTCCTCT
TGGGCATGTGCTTAGACGCCTGTGCTCGCTACCTTCTGTTCTCCAAGCAGCCGTCACAGGCACAAAGGATGTATGAAAAAGCTCTGCAGA
TTTCTGAAGAAATACAAGGAGAAAGACACCCACAGACCATTGTGCTGATGAGTGACCTGGCTACTACCCTGGATGCACAGGGCCGCTTTG
ATGAGGCCTATATTTATATGCAAAGGGCATCAGATCTGGCAAGACAGATAAATCATCCTGAGCTACACATGGTACTCAGTAATCTAGCTG
CAGTTTTGATGCACAGAGAACGATATACACAAGCAAAAGAGATCTACCAGGAAGCACTGAAGCAAGCAAAGCTGAAAAAAGATGAAATTT
CTGTACAACACATCAGGGAAGAGTTGGCTGAGCTGTCAAAGAAAAGTAGACCTTTGACAAATTCTGTCAAGCTCTAAATCCATTTTTGTG
TAGGGAGAATAATGTCTAGTAATGTGGAAGAATAGCTATCATTCCTGTCTCTGTGGCACCCGATCAATGGCTTAAATCTGTCGTTTTTGA
TATTCAGGTTTCCTCAATTTAGCCTTAGTGAAGGAGGGGTTGTACACACTGCCATTTTTGTATTTTAAAGGAAAAATGACTTTCATTCCC
AACTGATTATGACCTTTCAGGATGTCGTCAAGTGATGCTTTCAGTTGTAACACGTGACTTGGTGCTGTCCCTGCTGGTCTAAGTAGAACT
GTAGATTCATATGGGCTGGTGTTCCTGTGCGCTGTGGGTGTGGTGATTCAGCCTGGCATTTCTACCATAAGTTTTTGGTCTGCTGATTTG
CTGCCCTGTCTTCTCTTACTTTACTTTATCAATACCTGGCAAACTGACCAGAATTACCTTCCTCATGGCAAAGGGGGATTATGGTGAATT
GTTGTTCTTATAGTCTGTTTCATGAAGCACAAGTGGAATTTAATACATAAAAGAGAAAAATATCTTAGTTTGCTACCAGCATCCAGCATG
AAGTTGTAAAGTGGGGATTAGGCACGTGACAGTATAGCACCCATTTGAATTTAAATAAAAGTGAACCATATTTATCTGGTTATATAAAAC
TAAAAATGGGGGTGTTTATATAAAACTAAAAACTAAGAATGATGTAACCTTTTGTCTGTGTTATCTGAACACTCTACTTCCTTTGCAGCC
TTAGTCACACAACTGAGTCATCTCAAGTACTCTTTAAGGACACACAGCCCAGGCTGTTCTGAGTCAGAATAGGCCCCTACAGGTATATTT
TAAAACTCTTCGTAATTCTAATGTGTACTGCTGGTATAGCTGAACTACTGACCTGGATCTTAGTCCTAGCCTTTTTGCTTTTGCAATTTC
AGTATCTTCATCTCTAAACTAGGGAAACACTGGGATTCTTTCTTAGCTGTGGGGGAAGGTATTTGGTTAGATGACTTTGAATGAATAGAC
TGCTGTGCTGAAAGAGCTTTATCACACTGTCTCAAAGTATGTAAAGATACATAGGTGGATGCTCTTACTGCAGCAGTCATGAATACATTT
TTAGCCATTTACCTAAGGAAAAAGACAGTTTTTCTAGGTACCATGAAGGAAGATTGACCCTGTTGGTATGCCTGTGGGGGTGGGATGTGA

>In-frame_ENST00000304743_ENST00000486880_TCGA-61-2095_PCNX_chr14_71435827_+_TTC19_chr17_15928330_length(amino acids)=385AA_start in transcript=359_stop in transcript=1516
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMALPSTMIIVA
VYCPVIAAVFIVLKMVNYRLHRALDAGEVVDRTANEFTDQRTKAEQGNCSTRRKDSNGPSDPGGGIEMSEFIREATPPVGCSSRNSYAGL
DPSNQIGSGSSRLGTAATIKGDTDTAKTSDDISLSLGQSSSLCKEGSEEQVEEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQ
ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKLKKDEI

--------------------------------------------------------------
>In-frame_ENST00000439984_ENST00000261647_TCGA-61-2095_PCNX_chr14_71435827_+_TTC19_chr17_15928330_length(transcript)=2573nt_BP=716nt
CTCCGGAGGTGGATAGACGGGGCAGCTGCAGGCTCCGGCGACCGAGGCCGAGCTGGGGCCGGGGCGGGGACGGCGGCGGCGGCGGCGGCG
ACGGCGGCGGCGCCGGGTGGGGATGGGGTCGCAGACGCTGCAGATCCTCCGACAGGGGGTGTGGGCCGCGCTCAGCGGGGGCTGGTACTA
CGACCCGCACCAGGCCACCTTCGTGAACGCGCTGCACCTCTACCTGTGGCTCTTTCTGCTGGGCCTGCCCTTCACCCTCTACATGGCCCT
TCCTTCTACCATGATTATAGTAGCAGTTTATTGTCCTGTGATAGCTGCTGTTTTCATTGTTCTGAAGATGGTCAACTATCGACTACACAG
AGCACTTGATGCTGGAGAAGTTGTAGATAGGACTGCAAATGAGTTCACGGATCAGCGAACCAAAGCTGAACAAGGCAACTGTTCAACCAG
GAGAAAAGACAGCAATGGACCGAGTGATCCTGGTGGAGGGATTGAAATGTCTGAGTTCATCCGAGAGGCCACACCCCCAGTTGGTTGCAG
TTCCAGAAATTCTTATGCCGGTCTAGATCCAAGCAACCAGATTGGATCTGGTTCCTCGCGTCTTGGAACAGCAGCAACTATTAAAGGAGA
TACAGACACTGCTAAGACTTCTGATGATATCAGTTTAAGTCTGGGCCAAAGTTCTAGTCTTTGTAAGGAAGGAAGTGAAGAACAAGTGGA
AGAGAAAGCCAATACCCACCTCCTCTTGGGCATGTGCTTAGACGCCTGTGCTCGCTACCTTCTGTTCTCCAAGCAGCCGTCACAGGCACA
AAGGATGTATGAAAAAGCTCTGCAGATTTCTGAAGAAATACAAGGAGAAAGACACCCACAGACCATTGTGCTGATGAGTGACCTGGCTAC
TACCCTGGATGCACAGGGCCGCTTTGATGAGGCCTATATTTATATGCAAAGGGCATCAGATCTGGCAAGACAGATAAATCATCCTGAGCT
ACACATGGTACTCAGTAATCTAGCTGCAGTTTTGATGCACAGAGAACGATATACACAAGCAAAAGAGATCTACCAGGAAGCACTGAAGCA
AGCAAAGCTGAAAAAAGATGAAATTTCTGTACAACACATCAGGGAAGAGTTGGCTGAGCTGTCAAAGAAAAGTAGACCTTTGACAAATTC
TGTCAAGCTCTAAATCCATTTTTGTGTAGGGAGAATAATGTCTAGTAATGTGGAAGAATAGCTATCATTCCTGTCTCTGTGGCACCCGAT
CAATGGCTTAAATCTGTCGTTTTTGATATTCAGGTTTCCTCAATTTAGCCTTAGTGAAGGAGGGGTTGTACACACTGCCATTTTTGTATT
TTAAAGGAAAAATGACTTTCATTCCCAACTGATTATGACCTTTCAGGATGTCGTCAAGTGATGCTTTCAGTTGTAACACGTGACTTGGTG
CTGTCCCTGCTGGTCTAAGTAGAACTGTAGATTCATATGGGCTGGTGTTCCTGTGCGCTGTGGGTGTGGTGATTCAGCCTGGCATTTCTA
CCATAAGTTTTTGGTCTGCTGATTTGCTGCCCTGTCTTCTCTTACTTTACTTTATCAATACCTGGCAAACTGACCAGAATTACCTTCCTC
ATGGCAAAGGGGGATTATGGTGAATTGTTGTTCTTATAGTCTGTTTCATGAAGCACAAGTGGAATTTAATACATAAAAGAGAAAAATATC
TTAGTTTGCTACCAGCATCCAGCATGAAGTTGTAAAGTGGGGATTAGGCACGTGACAGTATAGCACCCATTTGAATTTAAATAAAAGTGA
ACCATATTTATCTGGTTATATAAAACTAAAAATGGGGGTGTTTATATAAAACTAAAAACTAAGAATGATGTAACCTTTTGTCTGTGTTAT
CTGAACACTCTACTTCCTTTGCAGCCTTAGTCACACAACTGAGTCATCTCAAGTACTCTTTAAGGACACACAGCCCAGGCTGTTCTGAGT
CAGAATAGGCCCCTACAGGTATATTTTAAAACTCTTCGTAATTCTAATGTGTACTGCTGGTATAGCTGAACTACTGACCTGGATCTTAGT
CCTAGCCTTTTTGCTTTTGCAATTTCAGTATCTTCATCTCTAAACTAGGGAAACACTGGGATTCTTTCTTAGCTGTGGGGGAAGGTATTT
GGTTAGATGACTTTGAATGAATAGACTGCTGTGCTGAAAGAGCTTTATCACACTGTCTCAAAGTATGTAAAGATACATAGGTGGATGCTC
TTACTGCAGCAGTCATGAATACATTTTTAGCCATTTACCTAAGGAAAAAGACAGTTTTTCTAGGTACCATGAAGGAAGATTGACCCTGTT
GGTATGCCTGTGGGGGTGGGATGTGAGTGGGACTGATAAACTGATACTTTTGGTTCGTATGTACATACTGGAAGAATCTTCATAATAAAT
GAGACTACACAACAATATTGTATGTATCCCAGTAATCTTTGCATTTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAACTTTCTGAAGAAA

>In-frame_ENST00000439984_ENST00000261647_TCGA-61-2095_PCNX_chr14_71435827_+_TTC19_chr17_15928330_length(amino acids)=385AA_start in transcript=25_stop in transcript=1182
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMALPSTMIIVA
VYCPVIAAVFIVLKMVNYRLHRALDAGEVVDRTANEFTDQRTKAEQGNCSTRRKDSNGPSDPGGGIEMSEFIREATPPVGCSSRNSYAGL
DPSNQIGSGSSRLGTAATIKGDTDTAKTSDDISLSLGQSSSLCKEGSEEQVEEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQ
ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKLKKDEI

--------------------------------------------------------------
>In-frame_ENST00000439984_ENST00000486880_TCGA-61-2095_PCNX_chr14_71435827_+_TTC19_chr17_15928330_length(transcript)=2443nt_BP=716nt
CTCCGGAGGTGGATAGACGGGGCAGCTGCAGGCTCCGGCGACCGAGGCCGAGCTGGGGCCGGGGCGGGGACGGCGGCGGCGGCGGCGGCG
ACGGCGGCGGCGCCGGGTGGGGATGGGGTCGCAGACGCTGCAGATCCTCCGACAGGGGGTGTGGGCCGCGCTCAGCGGGGGCTGGTACTA
CGACCCGCACCAGGCCACCTTCGTGAACGCGCTGCACCTCTACCTGTGGCTCTTTCTGCTGGGCCTGCCCTTCACCCTCTACATGGCCCT
TCCTTCTACCATGATTATAGTAGCAGTTTATTGTCCTGTGATAGCTGCTGTTTTCATTGTTCTGAAGATGGTCAACTATCGACTACACAG
AGCACTTGATGCTGGAGAAGTTGTAGATAGGACTGCAAATGAGTTCACGGATCAGCGAACCAAAGCTGAACAAGGCAACTGTTCAACCAG
GAGAAAAGACAGCAATGGACCGAGTGATCCTGGTGGAGGGATTGAAATGTCTGAGTTCATCCGAGAGGCCACACCCCCAGTTGGTTGCAG
TTCCAGAAATTCTTATGCCGGTCTAGATCCAAGCAACCAGATTGGATCTGGTTCCTCGCGTCTTGGAACAGCAGCAACTATTAAAGGAGA
TACAGACACTGCTAAGACTTCTGATGATATCAGTTTAAGTCTGGGCCAAAGTTCTAGTCTTTGTAAGGAAGGAAGTGAAGAACAAGTGGA
AGAGAAAGCCAATACCCACCTCCTCTTGGGCATGTGCTTAGACGCCTGTGCTCGCTACCTTCTGTTCTCCAAGCAGCCGTCACAGGCACA
AAGGATGTATGAAAAAGCTCTGCAGATTTCTGAAGAAATACAAGGAGAAAGACACCCACAGACCATTGTGCTGATGAGTGACCTGGCTAC
TACCCTGGATGCACAGGGCCGCTTTGATGAGGCCTATATTTATATGCAAAGGGCATCAGATCTGGCAAGACAGATAAATCATCCTGAGCT
ACACATGGTACTCAGTAATCTAGCTGCAGTTTTGATGCACAGAGAACGATATACACAAGCAAAAGAGATCTACCAGGAAGCACTGAAGCA
AGCAAAGCTGAAAAAAGATGAAATTTCTGTACAACACATCAGGGAAGAGTTGGCTGAGCTGTCAAAGAAAAGTAGACCTTTGACAAATTC
TGTCAAGCTCTAAATCCATTTTTGTGTAGGGAGAATAATGTCTAGTAATGTGGAAGAATAGCTATCATTCCTGTCTCTGTGGCACCCGAT
CAATGGCTTAAATCTGTCGTTTTTGATATTCAGGTTTCCTCAATTTAGCCTTAGTGAAGGAGGGGTTGTACACACTGCCATTTTTGTATT
TTAAAGGAAAAATGACTTTCATTCCCAACTGATTATGACCTTTCAGGATGTCGTCAAGTGATGCTTTCAGTTGTAACACGTGACTTGGTG
CTGTCCCTGCTGGTCTAAGTAGAACTGTAGATTCATATGGGCTGGTGTTCCTGTGCGCTGTGGGTGTGGTGATTCAGCCTGGCATTTCTA
CCATAAGTTTTTGGTCTGCTGATTTGCTGCCCTGTCTTCTCTTACTTTACTTTATCAATACCTGGCAAACTGACCAGAATTACCTTCCTC
ATGGCAAAGGGGGATTATGGTGAATTGTTGTTCTTATAGTCTGTTTCATGAAGCACAAGTGGAATTTAATACATAAAAGAGAAAAATATC
TTAGTTTGCTACCAGCATCCAGCATGAAGTTGTAAAGTGGGGATTAGGCACGTGACAGTATAGCACCCATTTGAATTTAAATAAAAGTGA
ACCATATTTATCTGGTTATATAAAACTAAAAATGGGGGTGTTTATATAAAACTAAAAACTAAGAATGATGTAACCTTTTGTCTGTGTTAT
CTGAACACTCTACTTCCTTTGCAGCCTTAGTCACACAACTGAGTCATCTCAAGTACTCTTTAAGGACACACAGCCCAGGCTGTTCTGAGT
CAGAATAGGCCCCTACAGGTATATTTTAAAACTCTTCGTAATTCTAATGTGTACTGCTGGTATAGCTGAACTACTGACCTGGATCTTAGT
CCTAGCCTTTTTGCTTTTGCAATTTCAGTATCTTCATCTCTAAACTAGGGAAACACTGGGATTCTTTCTTAGCTGTGGGGGAAGGTATTT
GGTTAGATGACTTTGAATGAATAGACTGCTGTGCTGAAAGAGCTTTATCACACTGTCTCAAAGTATGTAAAGATACATAGGTGGATGCTC
TTACTGCAGCAGTCATGAATACATTTTTAGCCATTTACCTAAGGAAAAAGACAGTTTTTCTAGGTACCATGAAGGAAGATTGACCCTGTT
GGTATGCCTGTGGGGGTGGGATGTGAGTGGGACTGATAAACTGATACTTTTGGTTCGTATGTACATACTGGAAGAATCTTCATAATAAAT

>In-frame_ENST00000439984_ENST00000486880_TCGA-61-2095_PCNX_chr14_71435827_+_TTC19_chr17_15928330_length(amino acids)=385AA_start in transcript=25_stop in transcript=1182
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMALPSTMIIVA
VYCPVIAAVFIVLKMVNYRLHRALDAGEVVDRTANEFTDQRTKAEQGNCSTRRKDSNGPSDPGGGIEMSEFIREATPPVGCSSRNSYAGL
DPSNQIGSGSSRLGTAATIKGDTDTAKTSDDISLSLGQSSSLCKEGSEEQVEEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQ
ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKLKKDEI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PCNX-TTC19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PCNX-TTC19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PCNX-TTC19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTTC19C0023264Leigh Disease8CLINGEN
TgeneTTC19C1838951LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY8CLINGEN
TgeneTTC19C1850597Leigh Syndrome Due To Mitochondrial Complex II Deficiency8CLINGEN
TgeneTTC19C1850598Leigh Syndrome due to Mitochondrial Complex III Deficiency8CLINGEN
TgeneTTC19C1850599Leigh Syndrome due to Mitochondrial Complex IV Deficiency8CLINGEN
TgeneTTC19C1850600Leigh Syndrome due to Mitochondrial Complex V Deficiency8CLINGEN
TgeneTTC19C2931891Necrotizing encephalopathy, infantile subacute, of Leigh8CLINGEN
TgeneTTC19C3554605MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 22GENOMICS_ENGLAND
TgeneTTC19C0021359Infertility1CTD_human
TgeneTTC19C0027765nervous system disorder1CTD_human
TgeneTTC19C0231686Gait, Unsteady1CTD_human
TgeneTTC19C0231687Spastic gait1CTD_human
TgeneTTC19C0231688Gait, Shuffling1CTD_human
TgeneTTC19C0231689Gait, Athetotic1CTD_human
TgeneTTC19C0231693Charcot Gait1CTD_human
TgeneTTC19C0231694Gait, Festinating1CTD_human
TgeneTTC19C0231695Cerebellar ataxic gait1CTD_human
TgeneTTC19C0231696Gait, Hemiplegic1CTD_human
TgeneTTC19C0231698Gait, Scissors1CTD_human
TgeneTTC19C0231712Waddling gait1CTD_human
TgeneTTC19C0234996Gait, Rigid1CTD_human
TgeneTTC19C0235000Gait, Broadened1CTD_human
TgeneTTC19C0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneTTC19C0337210Gait, Stumbling1CTD_human
TgeneTTC19C0427128Rapid Fatigue of Gait1CTD_human
TgeneTTC19C0427149Gait, Drop Foot1CTD_human
TgeneTTC19C0427169Marche a Petit Pas1CTD_human
TgeneTTC19C0427177Gait, Hysterical1CTD_human
TgeneTTC19C0524851Neurodegenerative Disorders1CTD_human
TgeneTTC19C0729353Subfertility1CTD_human
TgeneTTC19C0751651Mitochondrial Diseases1GENOMICS_ENGLAND
TgeneTTC19C0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneTTC19C0751829Gait Disorder, Sensorimotor1CTD_human
TgeneTTC19C0751830Gait Disorders, Neurologic1CTD_human
TgeneTTC19C0751831Gait, Frontal1CTD_human
TgeneTTC19C0751832Gait, Widebased1CTD_human
TgeneTTC19C4074771Sterility, Reproductive1CTD_human