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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ARHGEF11-CIT (FusionGDB2 ID:6307) |
Fusion Gene Summary for ARHGEF11-CIT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGEF11-CIT | Fusion gene ID: 6307 | Hgene | Tgene | Gene symbol | ARHGEF11 | CIT | Gene ID | 9826 | 79947 |
| Gene name | Rho guanine nucleotide exchange factor 11 | dehydrodolichyl diphosphate synthase subunit | |
| Synonyms | GTRAP48|PDZ-RHOGEF | CIT|CPT|DEDSM|DS|HDS|RP59|hCIT | |
| Cytomap | 1q23.1 | 1p36.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho guanine nucleotide exchange factor 11Rho guanine exchange factor (GEF) 11Rho guanine nucleotide exchange factor (GEF) 11RhoA-specific guanine nucleotide exchange factorRhoGEF glutamate transport modulatorglutamate transporter EAAT4-associated pro | dehydrodolichyl diphosphate synthase complex subunit DHDDScis-IPTasecis-isoprenyltransferasecis-prenyl transferasecis-prenyltransferase subunit hCITdedol-PP synthasedehydrodolichyl diphosphate syntase complex subunit DHDDSepididymis tissue protein | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | O15085 | Q96RK1 | |
| Ensembl transtripts involved in fusion gene | ENST00000368194, ENST00000487682, ENST00000361409, ENST00000315174, | ENST00000392521, ENST00000261833, ENST00000537607, | |
| Fusion gene scores | * DoF score | 11 X 5 X 7=385 | 4 X 4 X 4=64 |
| # samples | 14 | 5 | |
| ** MAII score | log2(14/385*10)=-1.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARHGEF11 [Title/Abstract] AND CIT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ARHGEF11(157014090)-CIT(120173162), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARHGEF11 | GO:0007186 | G protein-coupled receptor signaling pathway | 15755723 |
| Hgene | ARHGEF11 | GO:0007266 | Rho protein signal transduction | 10026210 |
| Hgene | ARHGEF11 | GO:0045893 | positive regulation of transcription, DNA-templated | 10026210 |
| Tgene | CIT | GO:0006489 | dolichyl diphosphate biosynthetic process | 28842490 |
| Fusion gene breakpoints across ARHGEF11 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across CIT (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-09-0369 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
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Fusion Gene ORF analysis for ARHGEF11-CIT |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000368194 | ENST00000392521 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
| In-frame | ENST00000368194 | ENST00000261833 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
| 5CDS-5UTR | ENST00000368194 | ENST00000537607 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
| intron-3CDS | ENST00000487682 | ENST00000392521 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
| intron-3CDS | ENST00000487682 | ENST00000261833 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
| intron-5UTR | ENST00000487682 | ENST00000537607 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
| In-frame | ENST00000361409 | ENST00000392521 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
| In-frame | ENST00000361409 | ENST00000261833 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
| 5CDS-5UTR | ENST00000361409 | ENST00000537607 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
| intron-3CDS | ENST00000315174 | ENST00000392521 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
| intron-3CDS | ENST00000315174 | ENST00000261833 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
| intron-5UTR | ENST00000315174 | ENST00000537607 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000368194 | ARHGEF11 | chr1 | 157014090 | - | ENST00000392521 | CIT | chr12 | 120173162 | - | 6766 | 1072 | 901 | 4323 | 1140 |
| ENST00000368194 | ARHGEF11 | chr1 | 157014090 | - | ENST00000261833 | CIT | chr12 | 120173162 | - | 6765 | 1072 | 901 | 4323 | 1140 |
| ENST00000361409 | ARHGEF11 | chr1 | 157014090 | - | ENST00000392521 | CIT | chr12 | 120173162 | - | 6469 | 775 | 604 | 4026 | 1140 |
| ENST00000361409 | ARHGEF11 | chr1 | 157014090 | - | ENST00000261833 | CIT | chr12 | 120173162 | - | 6468 | 775 | 604 | 4026 | 1140 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000368194 | ENST00000392521 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - | 0.002882588 | 0.9971174 |
| ENST00000368194 | ENST00000261833 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - | 0.002891144 | 0.9971089 |
| ENST00000361409 | ENST00000392521 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - | 0.002299754 | 0.9977003 |
| ENST00000361409 | ENST00000261833 | ARHGEF11 | chr1 | 157014090 | - | CIT | chr12 | 120173162 | - | 0.002306273 | 0.9976937 |
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Fusion Genomic Features for ARHGEF11-CIT |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ARHGEF11-CIT |
| Go to FGviewer for the breakpoints of chr1:157014090-chr12:120173162 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGEF11 | CIT |
| FUNCTION: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. | FUNCTION: Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000261833 | 22 | 47 | 1443_1563 | 944.0 | 2028.0 | Domain | PH | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000261833 | 22 | 47 | 1591_1881 | 944.0 | 2028.0 | Domain | CNH | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000392521 | 23 | 48 | 1443_1563 | 986.0 | 2070.0 | Domain | PH | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000392521 | 23 | 48 | 1591_1881 | 986.0 | 2070.0 | Domain | CNH | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000261833 | 22 | 47 | 1953_1958 | 944.0 | 2028.0 | Motif | SH3-binding | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000392521 | 23 | 48 | 1953_1958 | 986.0 | 2070.0 | Motif | SH3-binding | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000261833 | 22 | 47 | 1362_1411 | 944.0 | 2028.0 | Zinc finger | Phorbol-ester/DAG-type | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000392521 | 23 | 48 | 1362_1411 | 986.0 | 2070.0 | Zinc finger | Phorbol-ester/DAG-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARHGEF11 | chr1:157014090 | chr12:120173162 | ENST00000361409 | - | 1 | 40 | 444_470 | 10.666666666666666 | 1523.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARHGEF11 | chr1:157014090 | chr12:120173162 | ENST00000368194 | - | 1 | 41 | 444_470 | 10.666666666666666 | 1563.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ARHGEF11 | chr1:157014090 | chr12:120173162 | ENST00000361409 | - | 1 | 40 | 1094_1099 | 10.666666666666666 | 1523.0 | Compositional bias | Note=Poly-Pro |
| Hgene | ARHGEF11 | chr1:157014090 | chr12:120173162 | ENST00000368194 | - | 1 | 41 | 1094_1099 | 10.666666666666666 | 1563.0 | Compositional bias | Note=Poly-Pro |
| Hgene | ARHGEF11 | chr1:157014090 | chr12:120173162 | ENST00000361409 | - | 1 | 40 | 306_486 | 10.666666666666666 | 1523.0 | Domain | RGSL |
| Hgene | ARHGEF11 | chr1:157014090 | chr12:120173162 | ENST00000361409 | - | 1 | 40 | 47_126 | 10.666666666666666 | 1523.0 | Domain | PDZ |
| Hgene | ARHGEF11 | chr1:157014090 | chr12:120173162 | ENST00000361409 | - | 1 | 40 | 734_923 | 10.666666666666666 | 1523.0 | Domain | DH |
| Hgene | ARHGEF11 | chr1:157014090 | chr12:120173162 | ENST00000361409 | - | 1 | 40 | 965_1079 | 10.666666666666666 | 1523.0 | Domain | PH |
| Hgene | ARHGEF11 | chr1:157014090 | chr12:120173162 | ENST00000368194 | - | 1 | 41 | 306_486 | 10.666666666666666 | 1563.0 | Domain | RGSL |
| Hgene | ARHGEF11 | chr1:157014090 | chr12:120173162 | ENST00000368194 | - | 1 | 41 | 47_126 | 10.666666666666666 | 1563.0 | Domain | PDZ |
| Hgene | ARHGEF11 | chr1:157014090 | chr12:120173162 | ENST00000368194 | - | 1 | 41 | 734_923 | 10.666666666666666 | 1563.0 | Domain | DH |
| Hgene | ARHGEF11 | chr1:157014090 | chr12:120173162 | ENST00000368194 | - | 1 | 41 | 965_1079 | 10.666666666666666 | 1563.0 | Domain | PH |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000261833 | 22 | 47 | 453_1297 | 944.0 | 2028.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000392521 | 23 | 48 | 453_1297 | 986.0 | 2070.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000261833 | 22 | 47 | 361_431 | 944.0 | 2028.0 | Domain | AGC-kinase C-terminal | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000261833 | 22 | 47 | 97_360 | 944.0 | 2028.0 | Domain | Protein kinase | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000392521 | 23 | 48 | 361_431 | 986.0 | 2070.0 | Domain | AGC-kinase C-terminal | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000392521 | 23 | 48 | 97_360 | 986.0 | 2070.0 | Domain | Protein kinase | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000261833 | 22 | 47 | 103_111 | 944.0 | 2028.0 | Nucleotide binding | ATP | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000392521 | 23 | 48 | 103_111 | 986.0 | 2070.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for ARHGEF11-CIT |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000368194_ENST00000392521_TCGA-09-0369_ARHGEF11_chr1_157014090_-_CIT_chr12_120173162_length(transcript)=6766nt_BP=1072nt AGCGAAATCTCCGTTTCATGGAGGCTGAGGCAAGAGAAAATTTCGGAGCCTGGATGTGGAGGAGCCCAACAGCAGAACTAACTCAGGAAA TTGTCTTTCAGAAAAAGGCCGAACGTAGGCTGGGTCTGAGAATCAGGCTGGGGTAGGTGGAGGAACCTGCAAGTTTAAAGGAAAAAGAAA AGGAGAGAATATTTTCAGAGATTATCTCTGGTTTGTTATCATTACTACCATCTTAAAGGTAAAAAGCATTGCATTTCAGGTGTTCTTTGA TTTTTATTTTATTTTTTTTTTTGGTGCAATTGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTC CATAAATTTTGGTTCCCAGGGTTGCACTGGACTTGGAAGGAGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGT ACAAATCAGCCGAAAGAATTTTTCCAAGTGCCATTTCGGATTTATTAATCCTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCA TATTAAGCATTGGAGACTAGAAAATTACTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCAACAGAAGGACAGCTGAGAAAGCTGGATTTA AAGGATGGTTTTATCTGTACTTTGCAGTTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTTTTTTTTGGCCATAGTGCTAA CCTTGAAGAGATTCGTGGCTGGGTTTTTGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTCTTTTCTTTTC TTTTTTTTTAAAGCGGGGGAGGGGAAGAGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGT CCTGAGAGCTGGAGGAGAAAGGATTCTATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGAT CAAGACACCAAAGCTACAGGATTCTGGAACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTAATCAC AGACCTGGAGGAGCAGCTAAACCAGCTGACCGAGGACAACGCTGAACTCAACAACCAAAACTTCTACTTGTCCAAACAACTCGATGAGGC TTCTGGCGCCAACGACGAGATTGTACAACTGCGAAGTGAAGTGGACCATCTCCGCCGGGAGATCACGGAACGAGAGATGCAGCTTACCAG CCAGAAGCAAACGATGGAGGCTCTGAAGACCACGTGCACCATGCTGGAGGAACAGGTCATGGATTTGGAGGCCCTAAACGATGAGCTGCT AGAAAAAGAGCGGCAGTGGGAGGCCTGGAGGAGCGTCCTGGGTGATGAGAAATCCCAGTTTGAGTGTCGGGTTCGAGAGCTGCAGAGAAT GCTGGACACCGAGAAACAGAGCAGGGCGAGAGCCGATCAGCGGATCACCGAGTCTCGCCAGGTGGTGGAGCTGGCAGTGAAGGAGCACAA GGCTGAGATTCTCGCTCTGCAGCAGGCTCTCAAAGAGCAGAAGCTGAAGGCCGAGAGCCTCTCTGACAAGCTCAATGACCTGGAGAAGAA GCATGCTATGCTTGAAATGAATGCCCGAAGCTTACAGCAGAAGCTGGAGACTGAACGAGAGCTCAAACAGAGGCTTCTGGAAGAGCAAGC CAAATTACAGCAGCAGATGGACCTGCAGAAAAATCACATTTTCCGTCTGACTCAAGGACTGCAAGAAGCTCTAGATCGGGCTGATCTACT GAAGACAGAAAGAAGTGACTTGGAGTATCAGCTGGAAAACATTCAGGTTCTCTATTCTCATGAAAAGGTGAAAATGGAAGGCACTATTTC TCAACAAACCAAACTCATTGATTTTCTGCAAGCCAAAATGGACCAACCTGCTAAAAAGAAAAAGGGTTTATTTAGTCGACGGAAAGAGGA CCCTGCTTTACCCACACAGGTTCCTCTGCAGTACAATGAGCTGAAGCTGGCCCTGGAGAAGGAGAAAGCTCGCTGTGCAGAGCTAGAGGA AGCCCTTCAGAAGACCCGCATCGAGCTCCGGTCCGCCCGGGAGGAAGCTGCCCACCGCAAAGCAACGGACCACCCACACCCATCCACGCC AGCCACCGCGAGGCAGCAGATCGCCATGTCCGCCATCGTGCGGTCGCCAGAGCACCAGCCCAGTGCCATGAGCCTGCTGGCCCCGCCATC CAGCCGCAGAAAGGAGTCTTCAACTCCAGAGGAATTTAGTCGGCGTCTTAAGGAACGCATGCACCACAATATTCCTCACCGATTCAACGT AGGACTGAACATGCGAGCCACAAAGTGTGCTGTGTGTCTGGATACCGTGCACTTTGGACGCCAGGCATCCAAATGTCTCGAATGTCAGGT GATGTGTCACCCCAAGTGCTCCACGTGCTTGCCAGCCACCTGCGGCTTGCCTGCTGAATATGCCACACACTTCACCGAGGCCTTCTGCCG TGACAAAATGAACTCCCCAGGTCTCCAGACCAAGGAGCCCAGCAGCAGCTTGCACCTGGAAGGGTGGATGAAGGTGCCCAGGAATAACAA ACGAGGACAGCAAGGCTGGGACAGGAAGTACATTGTCCTGGAGGGATCAAAAGTCCTCATTTATGACAATGAAGCCAGAGAAGCTGGACA GAGGCCGGTGGAAGAATTTGAGCTGTGCCTTCCCGACGGGGATGTATCTATTCATGGTGCCGTTGGTGCTTCCGAACTCGCAAATACAGC CAAAGCAGATGTCCCATACATACTGAAGATGGAATCTCACCCGCACACCACCTGCTGGCCCGGGAGAACCCTCTACTTGCTAGCTCCCAG CTTCCCTGACAAACAGCGCTGGGTCACCGCCTTAGAATCAGTTGTCGCAGGTGGGAGAGTTTCTAGGGAAAAAGCAGAAGCTGATGCTAA ACTGCTTGGAAACTCCCTGCTGAAACTGGAAGGTGATGACCGTCTAGACATGAACTGCACGCTGCCCTTCAGTGACCAGGTGGTGTTGGT GGGCACCGAGGAAGGGCTCTACGCCCTGAATGTCTTGAAAAACTCCCTAACCCATGTCCCAGGAATTGGAGCAGTCTTCCAAATTTATAT TATCAAGGACCTGGAGAAGCTACTCATGATAGCAGGAGAAGAGCGGGCACTGTGTCTTGTGGACGTGAAGAAAGTGAAACAGTCCCTGGC CCAGTCCCACCTGCCTGCCCAGCCCGACATCTCACCCAACATTTTTGAAGCTGTCAAGGGCTGCCACTTGTTTGGGGCAGGCAAGATTGA GAACGGGCTCTGCATCTGTGCAGCCATGCCCAGCAAAGTCGTCATTCTCCGCTACAACGAAAACCTCAGCAAATACTGCATCCGGAAAGA GATAGAGACCTCAGAGCCCTGCAGCTGTATCCACTTCACCAATTACAGTATCCTCATTGGAACCAATAAATTCTACGAAATCGACATGAA GCAGTACACGCTCGAGGAATTCCTGGATAAGAATGACCATTCCTTGGCACCTGCTGTGTTTGCCGCCTCTTCCAACAGCTTCCCTGTCTC AATCGTGCAGGTGAACAGCGCAGGGCAGCGAGAGGAGTACTTGCTGTGTTTCCACGAATTTGGAGTGTTCGTGGATTCTTACGGAAGACG TAGCCGCACAGACGATCTCAAGTGGAGTCGCTTACCTTTGGCCTTTGCCTACAGAGAACCCTATCTGTTTGTGACCCACTTCAACTCACT CGAAGTAATTGAGATCCAGGCACGCTCCTCAGCAGGGACCCCTGCCCGAGCGTACCTGGACATCCCGAACCCGCGCTACCTGGGCCCTGC CATTTCCTCAGGAGCGATTTACTTGGCGTCCTCATACCAGGATAAATTAAGGGTCATTTGCTGCAAGGGAAACCTCGTGAAGGAGTCCGG CACTGAACACCACCGGGGCCCGTCCACCTCCCGCAGCAGCCCCAACAAGCGAGGCCCACCCACGTACAACGAGCACATCACCAAGCGCGT GGCCTCCAGCCCAGCGCCGCCCGAAGGCCCCAGCCACCCGCGAGAGCCAAGCACACCCCACCGCTACCGCGAGGGGCGGACCGAGCTGCG CAGGGACAAGTCTCCTGGCCGCCCCCTGGAGCGAGAGAAGTCCCCCGGCCGGATGCTCAGCACGCGGAGAGAGCGGTCCCCCGGGAGGCT GTTTGAAGACAGCAGCAGGGGCCGGCTGCCTGCGGGAGCCGTGAGGACCCCGCTGTCCCAGGTGAACAAGGTCTGGGACCAGTCTTCAGT ATAAATCTCAGCCAGAAAAACCAACTCCTCATCTTGATCTGCAGGAAAACACCAAACACACTATGGAACTCTGCTGATGGGGACCCAAGC GCCCACGTGCTCAGCCACCCTCTGGCTCAGCGGGGCCCAGACCCACCTCGGCACGGACACCCCTGTCTCCAGGAGGGGCAGGTGGCTGAG GCTCTTCGGAGCTGTCAGCGCCCGGTGCCTGCCCTGGGCACCTCCCTGCAGTCATCTCTTTGCACTTTGTTACTCTTTCAAAGCATTCAC AAACTTTTGTACCTAGCTCTAGCCTGTACCAGTTAGTTCATCAAAGGAAACCAACCGGGATGCTAACTACAACATGGTTAGAATCCTAAT TAGCTACTTTAAGATCCTAGGATTGGTTGGTTTTTCTTTTTTTTTTCTCTTTGTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAGACAACA GAATTCTTAATAGATTTGAATAGCGACGTATTTCCTGTTGTAGTCATTTTTAGCTCGACCACATCATCAGGTCTTTGCCACCGAGGCATA GTGTAGAACAGTCCCGGTCAGTTGGCCAACCTCCCGCAGCCAAGTAGGTTCATCCTTGTTCCTGTTCATTCTCATAGATGGCCCTGCTTT CCCCAGGGTGACATCGTAGCCAAATGTTTACTGTTTTCATTGCCTTTTATGGCCTTGACGACTTCCCCTCCCACCAGCTGAGAATGTATG GAGGTCATCGGGGCCTCAGCTCGGAGGCAGTGACTTGGGGCCAAGGGACCTCGAGACGCTTTCCTTCCCCACCCCCCAGCGTCATCTCCC CAGCCTGCTGTTCCCGCTTTCCATATAGCTTTGGCCAGGAAAGCATGCAATAGACTTGCTCGGAGCCCAGCACTCCTGGGTCTCGGGGTC GGGGAGGGGACGGGGGCACCCACTTCCTTGTCTGTGACGGCGTGTTGTTCCCCACTCTGGGATGGGGAAGAGGCCCGTCGGGAGTTCTGC ATGGCAGTTCACTGCATGTGCTGCCCCCTTGGGTTGCTCTGCCAATGTATTAATACCATCCCATAGCTCCTGCCAAATCGAGACCCTCTG ACGACTTGCCGACTAACTGGCCACCACAAGCTGCAGTCTGTAGCACTGAACAAACAAAAAACAAAACGCTCAAGCCTTACGACCAGAGAA GGATTTCAGCAAACCACCACCTCCCACTCAGTGTCCCCTCCAAACTTCACACTTCCCTGCCTGCAGAGGATGACTCTGTTCACACCCAAT CCAGCGCGGTTCTACCCCACGAAACTGTGACTTTCCAAATGAGCCTTTCCCTAGGGCTAGACCTAAGACCAGGAAGTTTGAGAAAGCAGC CGCAGCTCAACTCTTCCAGCTCCGCCAGGGTTGGGAAGTCCTTAGGTGCAGTGCGGCTCCCACTGGGTCTGCGGACCCTCCTATTAGAGT ACGAAATTCCTGGCAACTGGTACAGAACCAACCTAGAGGCTTTGCAGTTGGCAAGCTAACTCGCGGCCTTATTTCTGCCTTTAATCTCCC ACAAGGCATCTGTTGCTTTGGGTCCTCCACGACTCTTAGGCCCGCCTCAACAACCCAGGCACCTCCTAGGTAGGCTCAAAGGTAGACCCG TTTCCACCGCAGCAGGTGAACATGACCGTGTTTTCAACTGTGTCCACAGTTCAGATCCCTTTCCAGATTGCAACCTGGCCTGCATCCCAG CTCCTTCCTGCTCGTGTCTTAACCTAAGTGCTTTCTTGTTTGAAACGCCTACAAACCTCCATGTGGTAGCTCCTTTGGCAAATGTCCTGC TGTGGCGTTTTATGTGTTGCTTGGAGTCTGTGGGGTCGTACTCCCTCCCCTCCCGTCCCCAGGGCAGATTTGATTGAATGTTTGCTGAAG TTTTGTCTCTTGGTCCACAGTATTTGGAAAGGTCACTGAAAATGGGTCTTTCAGTCTTGGCATTTCATTTAGGATCTCCATGAGAAATGG GCTTCTTGAGCCCTGAAAATGTATATTGTGTGTCTCATCTGTGAACTGCTTTCTGCTATATAGAACTAGCTCAAAAGACTGTACATATTT ACAAGAAACTTTATATTCGTAAAAAAAAAAAGAGGAAATTGAATTGGTTTCTACTTTTTTATTGTAAAAGGTGCATTTTTCAACACTTAC TTTTGGTTTCAATGGTGGTAGTTGTGGACAGCCATCTTCACTGGAGGGTGGGGAGCTCCGTGTGACCACCAAGATGCCAGCAGGATATAC CGTAACACGAAATTGCTGTCAAAAGCTTATTAGCATCAATCAAGATTCTAGGTCTCCAAAAGTACAGGCTTTTTCTTCATTACCTTTTTT ATTCAGAACGAGGAAGAGAACACAAGGAATGATTCAAGATCCACCTTGAGAGGAATGAACTTTGTTGTTGAACAATTAGTGAAATAAAGC >In-frame_ENST00000368194_ENST00000392521_TCGA-09-0369_ARHGEF11_chr1_157014090_-_CIT_chr12_120173162_length(amino acids)=1140AA_start in transcript=901_stop in transcript=4323 MRAGGERILSSSWEALLSPCSKIASDSILIKTPKLQDSGTVETPRNHECKVTPEYRQVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA SGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM LDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA KLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKED PALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPS SRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCR DKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTA KADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLV GTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIE NGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVS IVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPA ISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELR -------------------------------------------------------------- >In-frame_ENST00000368194_ENST00000261833_TCGA-09-0369_ARHGEF11_chr1_157014090_-_CIT_chr12_120173162_length(transcript)=6765nt_BP=1072nt AGCGAAATCTCCGTTTCATGGAGGCTGAGGCAAGAGAAAATTTCGGAGCCTGGATGTGGAGGAGCCCAACAGCAGAACTAACTCAGGAAA TTGTCTTTCAGAAAAAGGCCGAACGTAGGCTGGGTCTGAGAATCAGGCTGGGGTAGGTGGAGGAACCTGCAAGTTTAAAGGAAAAAGAAA AGGAGAGAATATTTTCAGAGATTATCTCTGGTTTGTTATCATTACTACCATCTTAAAGGTAAAAAGCATTGCATTTCAGGTGTTCTTTGA TTTTTATTTTATTTTTTTTTTTGGTGCAATTGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTC CATAAATTTTGGTTCCCAGGGTTGCACTGGACTTGGAAGGAGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGT ACAAATCAGCCGAAAGAATTTTTCCAAGTGCCATTTCGGATTTATTAATCCTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCA TATTAAGCATTGGAGACTAGAAAATTACTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCAACAGAAGGACAGCTGAGAAAGCTGGATTTA AAGGATGGTTTTATCTGTACTTTGCAGTTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTTTTTTTTGGCCATAGTGCTAA CCTTGAAGAGATTCGTGGCTGGGTTTTTGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTCTTTTCTTTTC TTTTTTTTTAAAGCGGGGGAGGGGAAGAGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGT CCTGAGAGCTGGAGGAGAAAGGATTCTATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGAT CAAGACACCAAAGCTACAGGATTCTGGAACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTAATCAC AGACCTGGAGGAGCAGCTAAACCAGCTGACCGAGGACAACGCTGAACTCAACAACCAAAACTTCTACTTGTCCAAACAACTCGATGAGGC TTCTGGCGCCAACGACGAGATTGTACAACTGCGAAGTGAAGTGGACCATCTCCGCCGGGAGATCACGGAACGAGAGATGCAGCTTACCAG CCAGAAGCAAACGATGGAGGCTCTGAAGACCACGTGCACCATGCTGGAGGAACAGGTCATGGATTTGGAGGCCCTAAACGATGAGCTGCT AGAAAAAGAGCGGCAGTGGGAGGCCTGGAGGAGCGTCCTGGGTGATGAGAAATCCCAGTTTGAGTGTCGGGTTCGAGAGCTGCAGAGAAT GCTGGACACCGAGAAACAGAGCAGGGCGAGAGCCGATCAGCGGATCACCGAGTCTCGCCAGGTGGTGGAGCTGGCAGTGAAGGAGCACAA GGCTGAGATTCTCGCTCTGCAGCAGGCTCTCAAAGAGCAGAAGCTGAAGGCCGAGAGCCTCTCTGACAAGCTCAATGACCTGGAGAAGAA GCATGCTATGCTTGAAATGAATGCCCGAAGCTTACAGCAGAAGCTGGAGACTGAACGAGAGCTCAAACAGAGGCTTCTGGAAGAGCAAGC CAAATTACAGCAGCAGATGGACCTGCAGAAAAATCACATTTTCCGTCTGACTCAAGGACTGCAAGAAGCTCTAGATCGGGCTGATCTACT GAAGACAGAAAGAAGTGACTTGGAGTATCAGCTGGAAAACATTCAGGTTCTCTATTCTCATGAAAAGGTGAAAATGGAAGGCACTATTTC TCAACAAACCAAACTCATTGATTTTCTGCAAGCCAAAATGGACCAACCTGCTAAAAAGAAAAAGGGTTTATTTAGTCGACGGAAAGAGGA CCCTGCTTTACCCACACAGGTTCCTCTGCAGTACAATGAGCTGAAGCTGGCCCTGGAGAAGGAGAAAGCTCGCTGTGCAGAGCTAGAGGA AGCCCTTCAGAAGACCCGCATCGAGCTCCGGTCCGCCCGGGAGGAAGCTGCCCACCGCAAAGCAACGGACCACCCACACCCATCCACGCC AGCCACCGCGAGGCAGCAGATCGCCATGTCCGCCATCGTGCGGTCGCCAGAGCACCAGCCCAGTGCCATGAGCCTGCTGGCCCCGCCATC CAGCCGCAGAAAGGAGTCTTCAACTCCAGAGGAATTTAGTCGGCGTCTTAAGGAACGCATGCACCACAATATTCCTCACCGATTCAACGT AGGACTGAACATGCGAGCCACAAAGTGTGCTGTGTGTCTGGATACCGTGCACTTTGGACGCCAGGCATCCAAATGTCTCGAATGTCAGGT GATGTGTCACCCCAAGTGCTCCACGTGCTTGCCAGCCACCTGCGGCTTGCCTGCTGAATATGCCACACACTTCACCGAGGCCTTCTGCCG TGACAAAATGAACTCCCCAGGTCTCCAGACCAAGGAGCCCAGCAGCAGCTTGCACCTGGAAGGGTGGATGAAGGTGCCCAGGAATAACAA ACGAGGACAGCAAGGCTGGGACAGGAAGTACATTGTCCTGGAGGGATCAAAAGTCCTCATTTATGACAATGAAGCCAGAGAAGCTGGACA GAGGCCGGTGGAAGAATTTGAGCTGTGCCTTCCCGACGGGGATGTATCTATTCATGGTGCCGTTGGTGCTTCCGAACTCGCAAATACAGC CAAAGCAGATGTCCCATACATACTGAAGATGGAATCTCACCCGCACACCACCTGCTGGCCCGGGAGAACCCTCTACTTGCTAGCTCCCAG CTTCCCTGACAAACAGCGCTGGGTCACCGCCTTAGAATCAGTTGTCGCAGGTGGGAGAGTTTCTAGGGAAAAAGCAGAAGCTGATGCTAA ACTGCTTGGAAACTCCCTGCTGAAACTGGAAGGTGATGACCGTCTAGACATGAACTGCACGCTGCCCTTCAGTGACCAGGTGGTGTTGGT GGGCACCGAGGAAGGGCTCTACGCCCTGAATGTCTTGAAAAACTCCCTAACCCATGTCCCAGGAATTGGAGCAGTCTTCCAAATTTATAT TATCAAGGACCTGGAGAAGCTACTCATGATAGCAGGAGAAGAGCGGGCACTGTGTCTTGTGGACGTGAAGAAAGTGAAACAGTCCCTGGC CCAGTCCCACCTGCCTGCCCAGCCCGACATCTCACCCAACATTTTTGAAGCTGTCAAGGGCTGCCACTTGTTTGGGGCAGGCAAGATTGA GAACGGGCTCTGCATCTGTGCAGCCATGCCCAGCAAAGTCGTCATTCTCCGCTACAACGAAAACCTCAGCAAATACTGCATCCGGAAAGA GATAGAGACCTCAGAGCCCTGCAGCTGTATCCACTTCACCAATTACAGTATCCTCATTGGAACCAATAAATTCTACGAAATCGACATGAA GCAGTACACGCTCGAGGAATTCCTGGATAAGAATGACCATTCCTTGGCACCTGCTGTGTTTGCCGCCTCTTCCAACAGCTTCCCTGTCTC AATCGTGCAGGTGAACAGCGCAGGGCAGCGAGAGGAGTACTTGCTGTGTTTCCACGAATTTGGAGTGTTCGTGGATTCTTACGGAAGACG TAGCCGCACAGACGATCTCAAGTGGAGTCGCTTACCTTTGGCCTTTGCCTACAGAGAACCCTATCTGTTTGTGACCCACTTCAACTCACT CGAAGTAATTGAGATCCAGGCACGCTCCTCAGCAGGGACCCCTGCCCGAGCGTACCTGGACATCCCGAACCCGCGCTACCTGGGCCCTGC CATTTCCTCAGGAGCGATTTACTTGGCGTCCTCATACCAGGATAAATTAAGGGTCATTTGCTGCAAGGGAAACCTCGTGAAGGAGTCCGG CACTGAACACCACCGGGGCCCGTCCACCTCCCGCAGCAGCCCCAACAAGCGAGGCCCACCCACGTACAACGAGCACATCACCAAGCGCGT GGCCTCCAGCCCAGCGCCGCCCGAAGGCCCCAGCCACCCGCGAGAGCCAAGCACACCCCACCGCTACCGCGAGGGGCGGACCGAGCTGCG CAGGGACAAGTCTCCTGGCCGCCCCCTGGAGCGAGAGAAGTCCCCCGGCCGGATGCTCAGCACGCGGAGAGAGCGGTCCCCCGGGAGGCT GTTTGAAGACAGCAGCAGGGGCCGGCTGCCTGCGGGAGCCGTGAGGACCCCGCTGTCCCAGGTGAACAAGGTCTGGGACCAGTCTTCAGT ATAAATCTCAGCCAGAAAAACCAACTCCTCATCTTGATCTGCAGGAAAACACCAAACACACTATGGAACTCTGCTGATGGGGACCCAAGC GCCCACGTGCTCAGCCACCCTCTGGCTCAGCGGGGCCCAGACCCACCTCGGCACGGACACCCCTGTCTCCAGGAGGGGCAGGTGGCTGAG GCTCTTCGGAGCTGTCAGCGCCCGGTGCCTGCCCTGGGCACCTCCCTGCAGTCATCTCTTTGCACTTTGTTACTCTTTCAAAGCATTCAC AAACTTTTGTACCTAGCTCTAGCCTGTACCAGTTAGTTCATCAAAGGAAACCAACCGGGATGCTAACTACAACATGGTTAGAATCCTAAT TAGCTACTTTAAGATCCTAGGATTGGTTGGTTTTTCTTTTTTTTTTCTCTTTGTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAGACAACA GAATTCTTAATAGATTTGAATAGCGACGTATTTCCTGTTGTAGTCATTTTTAGCTCGACCACATCATCAGGTCTTTGCCACCGAGGCATA GTGTAGAACAGTCCCGGTCAGTTGGCCAACCTCCCGCAGCCAAGTAGGTTCATCCTTGTTCCTGTTCATTCTCATAGATGGCCCTGCTTT CCCCAGGGTGACATCGTAGCCAAATGTTTACTGTTTTCATTGCCTTTTATGGCCTTGACGACTTCCCCTCCCACCAGCTGAGAATGTATG GAGGTCATCGGGGCCTCAGCTCGGAGGCAGTGACTTGGGGCCAAGGGACCTCGAGACGCTTTCCTTCCCCACCCCCCAGCGTCATCTCCC CAGCCTGCTGTTCCCGCTTTCCATATAGCTTTGGCCAGGAAAGCATGCAATAGACTTGCTCGGAGCCCAGCACTCCTGGGTCTCGGGGTC GGGGAGGGGACGGGGGCACCCACTTCCTTGTCTGTGACGGCGTGTTGTTCCCCACTCTGGGATGGGGAAGAGGCCCGTCGGGAGTTCTGC ATGGCAGTTCACTGCATGTGCTGCCCCCTTGGGTTGCTCTGCCAATGTATTAATACCATCCCATAGCTCCTGCCAAATCGAGACCCTCTG ACGACTTGCCGACTAACTGGCCACCACAAGCTGCAGTCTGTAGCACTGAACAAACAAAAAACAAAACGCTCAAGCCTTACGACCAGAGAA GGATTTCAGCAAACCACCACCTCCCACTCAGTGTCCCCTCCAAACTTCACACTTCCCTGCCTGCAGAGGATGACTCTGTTCACACCCAAT CCAGCGCGGTTCTACCCCACGAAACTGTGACTTTCCAAATGAGCCTTTCCCTAGGGCTAGACCTAAGACCAGGAAGTTTGAGAAAGCAGC CGCAGCTCAACTCTTCCAGCTCCGCCAGGGTTGGGAAGTCCTTAGGTGCAGTGCGGCTCCCACTGGGTCTGCGGACCCTCCTATTAGAGT ACGAAATTCCTGGCAACTGGTACAGAACCAACCTAGAGGCTTTGCAGTTGGCAAGCTAACTCGCGGCCTTATTTCTGCCTTTAATCTCCC ACAAGGCATCTGTTGCTTTGGGTCCTCCACGACTCTTAGGCCCGCCTCAACAACCCAGGCACCTCCTAGGTAGGCTCAAAGGTAGACCCG TTTCCACCGCAGCAGGTGAACATGACCGTGTTTTCAACTGTGTCCACAGTTCAGATCCCTTTCCAGATTGCAACCTGGCCTGCATCCCAG CTCCTTCCTGCTCGTGTCTTAACCTAAGTGCTTTCTTGTTTGAAACGCCTACAAACCTCCATGTGGTAGCTCCTTTGGCAAATGTCCTGC TGTGGCGTTTTATGTGTTGCTTGGAGTCTGTGGGGTCGTACTCCCTCCCCTCCCGTCCCCAGGGCAGATTTGATTGAATGTTTGCTGAAG TTTTGTCTCTTGGTCCACAGTATTTGGAAAGGTCACTGAAAATGGGTCTTTCAGTCTTGGCATTTCATTTAGGATCTCCATGAGAAATGG GCTTCTTGAGCCCTGAAAATGTATATTGTGTGTCTCATCTGTGAACTGCTTTCTGCTATATAGAACTAGCTCAAAAGACTGTACATATTT ACAAGAAACTTTATATTCGTAAAAAAAAAAAGAGGAAATTGAATTGGTTTCTACTTTTTTATTGTAAAAGGTGCATTTTTCAACACTTAC TTTTGGTTTCAATGGTGGTAGTTGTGGACAGCCATCTTCACTGGAGGGTGGGGAGCTCCGTGTGACCACCAAGATGCCAGCAGGATATAC CGTAACACGAAATTGCTGTCAAAAGCTTATTAGCATCAATCAAGATTCTAGGTCTCCAAAAGTACAGGCTTTTTCTTCATTACCTTTTTT ATTCAGAACGAGGAAGAGAACACAAGGAATGATTCAAGATCCACCTTGAGAGGAATGAACTTTGTTGTTGAACAATTAGTGAAATAAAGC >In-frame_ENST00000368194_ENST00000261833_TCGA-09-0369_ARHGEF11_chr1_157014090_-_CIT_chr12_120173162_length(amino acids)=1140AA_start in transcript=901_stop in transcript=4323 MRAGGERILSSSWEALLSPCSKIASDSILIKTPKLQDSGTVETPRNHECKVTPEYRQVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA SGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM LDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA KLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKED PALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPS SRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCR DKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTA KADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLV GTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIE NGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVS IVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPA ISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELR -------------------------------------------------------------- >In-frame_ENST00000361409_ENST00000392521_TCGA-09-0369_ARHGEF11_chr1_157014090_-_CIT_chr12_120173162_length(transcript)=6469nt_BP=775nt AATTGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTCCATAAATTTTGGTTCCCAGGGTTGCAC TGGACTTGGAAGGAGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGTACAAATCAGCCGAAAGAATTTTTCCAA GTGCCATTTCGGATTTATTAATCCTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCATATTAAGCATTGGAGACTAGAAAATTA CTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCAACAGAAGGACAGCTGAGAAAGCTGGATTTAAAGGATGGTTTTATCTGTACTTTGCAG TTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTTTTTTTTGGCCATAGTGCTAACCTTGAAGAGATTCGTGGCTGGGTTTT TGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTCTTTTCTTTTCTTTTTTTTTAAAGCGGGGGAGGGGAAG AGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGTCCTGAGAGCTGGAGGAGAAAGGATTCT ATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGATCAAGACACCAAAGCTACAGGATTCTGG AACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTAATCACAGACCTGGAGGAGCAGCTAAACCAGCT GACCGAGGACAACGCTGAACTCAACAACCAAAACTTCTACTTGTCCAAACAACTCGATGAGGCTTCTGGCGCCAACGACGAGATTGTACA ACTGCGAAGTGAAGTGGACCATCTCCGCCGGGAGATCACGGAACGAGAGATGCAGCTTACCAGCCAGAAGCAAACGATGGAGGCTCTGAA GACCACGTGCACCATGCTGGAGGAACAGGTCATGGATTTGGAGGCCCTAAACGATGAGCTGCTAGAAAAAGAGCGGCAGTGGGAGGCCTG GAGGAGCGTCCTGGGTGATGAGAAATCCCAGTTTGAGTGTCGGGTTCGAGAGCTGCAGAGAATGCTGGACACCGAGAAACAGAGCAGGGC GAGAGCCGATCAGCGGATCACCGAGTCTCGCCAGGTGGTGGAGCTGGCAGTGAAGGAGCACAAGGCTGAGATTCTCGCTCTGCAGCAGGC TCTCAAAGAGCAGAAGCTGAAGGCCGAGAGCCTCTCTGACAAGCTCAATGACCTGGAGAAGAAGCATGCTATGCTTGAAATGAATGCCCG AAGCTTACAGCAGAAGCTGGAGACTGAACGAGAGCTCAAACAGAGGCTTCTGGAAGAGCAAGCCAAATTACAGCAGCAGATGGACCTGCA GAAAAATCACATTTTCCGTCTGACTCAAGGACTGCAAGAAGCTCTAGATCGGGCTGATCTACTGAAGACAGAAAGAAGTGACTTGGAGTA TCAGCTGGAAAACATTCAGGTTCTCTATTCTCATGAAAAGGTGAAAATGGAAGGCACTATTTCTCAACAAACCAAACTCATTGATTTTCT GCAAGCCAAAATGGACCAACCTGCTAAAAAGAAAAAGGGTTTATTTAGTCGACGGAAAGAGGACCCTGCTTTACCCACACAGGTTCCTCT GCAGTACAATGAGCTGAAGCTGGCCCTGGAGAAGGAGAAAGCTCGCTGTGCAGAGCTAGAGGAAGCCCTTCAGAAGACCCGCATCGAGCT CCGGTCCGCCCGGGAGGAAGCTGCCCACCGCAAAGCAACGGACCACCCACACCCATCCACGCCAGCCACCGCGAGGCAGCAGATCGCCAT GTCCGCCATCGTGCGGTCGCCAGAGCACCAGCCCAGTGCCATGAGCCTGCTGGCCCCGCCATCCAGCCGCAGAAAGGAGTCTTCAACTCC AGAGGAATTTAGTCGGCGTCTTAAGGAACGCATGCACCACAATATTCCTCACCGATTCAACGTAGGACTGAACATGCGAGCCACAAAGTG TGCTGTGTGTCTGGATACCGTGCACTTTGGACGCCAGGCATCCAAATGTCTCGAATGTCAGGTGATGTGTCACCCCAAGTGCTCCACGTG CTTGCCAGCCACCTGCGGCTTGCCTGCTGAATATGCCACACACTTCACCGAGGCCTTCTGCCGTGACAAAATGAACTCCCCAGGTCTCCA GACCAAGGAGCCCAGCAGCAGCTTGCACCTGGAAGGGTGGATGAAGGTGCCCAGGAATAACAAACGAGGACAGCAAGGCTGGGACAGGAA GTACATTGTCCTGGAGGGATCAAAAGTCCTCATTTATGACAATGAAGCCAGAGAAGCTGGACAGAGGCCGGTGGAAGAATTTGAGCTGTG CCTTCCCGACGGGGATGTATCTATTCATGGTGCCGTTGGTGCTTCCGAACTCGCAAATACAGCCAAAGCAGATGTCCCATACATACTGAA GATGGAATCTCACCCGCACACCACCTGCTGGCCCGGGAGAACCCTCTACTTGCTAGCTCCCAGCTTCCCTGACAAACAGCGCTGGGTCAC CGCCTTAGAATCAGTTGTCGCAGGTGGGAGAGTTTCTAGGGAAAAAGCAGAAGCTGATGCTAAACTGCTTGGAAACTCCCTGCTGAAACT GGAAGGTGATGACCGTCTAGACATGAACTGCACGCTGCCCTTCAGTGACCAGGTGGTGTTGGTGGGCACCGAGGAAGGGCTCTACGCCCT GAATGTCTTGAAAAACTCCCTAACCCATGTCCCAGGAATTGGAGCAGTCTTCCAAATTTATATTATCAAGGACCTGGAGAAGCTACTCAT GATAGCAGGAGAAGAGCGGGCACTGTGTCTTGTGGACGTGAAGAAAGTGAAACAGTCCCTGGCCCAGTCCCACCTGCCTGCCCAGCCCGA CATCTCACCCAACATTTTTGAAGCTGTCAAGGGCTGCCACTTGTTTGGGGCAGGCAAGATTGAGAACGGGCTCTGCATCTGTGCAGCCAT GCCCAGCAAAGTCGTCATTCTCCGCTACAACGAAAACCTCAGCAAATACTGCATCCGGAAAGAGATAGAGACCTCAGAGCCCTGCAGCTG TATCCACTTCACCAATTACAGTATCCTCATTGGAACCAATAAATTCTACGAAATCGACATGAAGCAGTACACGCTCGAGGAATTCCTGGA TAAGAATGACCATTCCTTGGCACCTGCTGTGTTTGCCGCCTCTTCCAACAGCTTCCCTGTCTCAATCGTGCAGGTGAACAGCGCAGGGCA GCGAGAGGAGTACTTGCTGTGTTTCCACGAATTTGGAGTGTTCGTGGATTCTTACGGAAGACGTAGCCGCACAGACGATCTCAAGTGGAG TCGCTTACCTTTGGCCTTTGCCTACAGAGAACCCTATCTGTTTGTGACCCACTTCAACTCACTCGAAGTAATTGAGATCCAGGCACGCTC CTCAGCAGGGACCCCTGCCCGAGCGTACCTGGACATCCCGAACCCGCGCTACCTGGGCCCTGCCATTTCCTCAGGAGCGATTTACTTGGC GTCCTCATACCAGGATAAATTAAGGGTCATTTGCTGCAAGGGAAACCTCGTGAAGGAGTCCGGCACTGAACACCACCGGGGCCCGTCCAC CTCCCGCAGCAGCCCCAACAAGCGAGGCCCACCCACGTACAACGAGCACATCACCAAGCGCGTGGCCTCCAGCCCAGCGCCGCCCGAAGG CCCCAGCCACCCGCGAGAGCCAAGCACACCCCACCGCTACCGCGAGGGGCGGACCGAGCTGCGCAGGGACAAGTCTCCTGGCCGCCCCCT GGAGCGAGAGAAGTCCCCCGGCCGGATGCTCAGCACGCGGAGAGAGCGGTCCCCCGGGAGGCTGTTTGAAGACAGCAGCAGGGGCCGGCT GCCTGCGGGAGCCGTGAGGACCCCGCTGTCCCAGGTGAACAAGGTCTGGGACCAGTCTTCAGTATAAATCTCAGCCAGAAAAACCAACTC CTCATCTTGATCTGCAGGAAAACACCAAACACACTATGGAACTCTGCTGATGGGGACCCAAGCGCCCACGTGCTCAGCCACCCTCTGGCT CAGCGGGGCCCAGACCCACCTCGGCACGGACACCCCTGTCTCCAGGAGGGGCAGGTGGCTGAGGCTCTTCGGAGCTGTCAGCGCCCGGTG CCTGCCCTGGGCACCTCCCTGCAGTCATCTCTTTGCACTTTGTTACTCTTTCAAAGCATTCACAAACTTTTGTACCTAGCTCTAGCCTGT ACCAGTTAGTTCATCAAAGGAAACCAACCGGGATGCTAACTACAACATGGTTAGAATCCTAATTAGCTACTTTAAGATCCTAGGATTGGT TGGTTTTTCTTTTTTTTTTCTCTTTGTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAGACAACAGAATTCTTAATAGATTTGAATAGCGAC GTATTTCCTGTTGTAGTCATTTTTAGCTCGACCACATCATCAGGTCTTTGCCACCGAGGCATAGTGTAGAACAGTCCCGGTCAGTTGGCC AACCTCCCGCAGCCAAGTAGGTTCATCCTTGTTCCTGTTCATTCTCATAGATGGCCCTGCTTTCCCCAGGGTGACATCGTAGCCAAATGT TTACTGTTTTCATTGCCTTTTATGGCCTTGACGACTTCCCCTCCCACCAGCTGAGAATGTATGGAGGTCATCGGGGCCTCAGCTCGGAGG CAGTGACTTGGGGCCAAGGGACCTCGAGACGCTTTCCTTCCCCACCCCCCAGCGTCATCTCCCCAGCCTGCTGTTCCCGCTTTCCATATA GCTTTGGCCAGGAAAGCATGCAATAGACTTGCTCGGAGCCCAGCACTCCTGGGTCTCGGGGTCGGGGAGGGGACGGGGGCACCCACTTCC TTGTCTGTGACGGCGTGTTGTTCCCCACTCTGGGATGGGGAAGAGGCCCGTCGGGAGTTCTGCATGGCAGTTCACTGCATGTGCTGCCCC CTTGGGTTGCTCTGCCAATGTATTAATACCATCCCATAGCTCCTGCCAAATCGAGACCCTCTGACGACTTGCCGACTAACTGGCCACCAC AAGCTGCAGTCTGTAGCACTGAACAAACAAAAAACAAAACGCTCAAGCCTTACGACCAGAGAAGGATTTCAGCAAACCACCACCTCCCAC TCAGTGTCCCCTCCAAACTTCACACTTCCCTGCCTGCAGAGGATGACTCTGTTCACACCCAATCCAGCGCGGTTCTACCCCACGAAACTG TGACTTTCCAAATGAGCCTTTCCCTAGGGCTAGACCTAAGACCAGGAAGTTTGAGAAAGCAGCCGCAGCTCAACTCTTCCAGCTCCGCCA GGGTTGGGAAGTCCTTAGGTGCAGTGCGGCTCCCACTGGGTCTGCGGACCCTCCTATTAGAGTACGAAATTCCTGGCAACTGGTACAGAA CCAACCTAGAGGCTTTGCAGTTGGCAAGCTAACTCGCGGCCTTATTTCTGCCTTTAATCTCCCACAAGGCATCTGTTGCTTTGGGTCCTC CACGACTCTTAGGCCCGCCTCAACAACCCAGGCACCTCCTAGGTAGGCTCAAAGGTAGACCCGTTTCCACCGCAGCAGGTGAACATGACC GTGTTTTCAACTGTGTCCACAGTTCAGATCCCTTTCCAGATTGCAACCTGGCCTGCATCCCAGCTCCTTCCTGCTCGTGTCTTAACCTAA GTGCTTTCTTGTTTGAAACGCCTACAAACCTCCATGTGGTAGCTCCTTTGGCAAATGTCCTGCTGTGGCGTTTTATGTGTTGCTTGGAGT CTGTGGGGTCGTACTCCCTCCCCTCCCGTCCCCAGGGCAGATTTGATTGAATGTTTGCTGAAGTTTTGTCTCTTGGTCCACAGTATTTGG AAAGGTCACTGAAAATGGGTCTTTCAGTCTTGGCATTTCATTTAGGATCTCCATGAGAAATGGGCTTCTTGAGCCCTGAAAATGTATATT GTGTGTCTCATCTGTGAACTGCTTTCTGCTATATAGAACTAGCTCAAAAGACTGTACATATTTACAAGAAACTTTATATTCGTAAAAAAA AAAAGAGGAAATTGAATTGGTTTCTACTTTTTTATTGTAAAAGGTGCATTTTTCAACACTTACTTTTGGTTTCAATGGTGGTAGTTGTGG ACAGCCATCTTCACTGGAGGGTGGGGAGCTCCGTGTGACCACCAAGATGCCAGCAGGATATACCGTAACACGAAATTGCTGTCAAAAGCT TATTAGCATCAATCAAGATTCTAGGTCTCCAAAAGTACAGGCTTTTTCTTCATTACCTTTTTTATTCAGAACGAGGAAGAGAACACAAGG >In-frame_ENST00000361409_ENST00000392521_TCGA-09-0369_ARHGEF11_chr1_157014090_-_CIT_chr12_120173162_length(amino acids)=1140AA_start in transcript=604_stop in transcript=4026 MRAGGERILSSSWEALLSPCSKIASDSILIKTPKLQDSGTVETPRNHECKVTPEYRQVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA SGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM LDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA KLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKED PALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPS SRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCR DKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTA KADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLV GTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIE NGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVS IVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPA ISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELR -------------------------------------------------------------- >In-frame_ENST00000361409_ENST00000261833_TCGA-09-0369_ARHGEF11_chr1_157014090_-_CIT_chr12_120173162_length(transcript)=6468nt_BP=775nt AATTGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTCCATAAATTTTGGTTCCCAGGGTTGCAC TGGACTTGGAAGGAGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGTACAAATCAGCCGAAAGAATTTTTCCAA GTGCCATTTCGGATTTATTAATCCTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCATATTAAGCATTGGAGACTAGAAAATTA CTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCAACAGAAGGACAGCTGAGAAAGCTGGATTTAAAGGATGGTTTTATCTGTACTTTGCAG TTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTTTTTTTTGGCCATAGTGCTAACCTTGAAGAGATTCGTGGCTGGGTTTT TGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTCTTTTCTTTTCTTTTTTTTTAAAGCGGGGGAGGGGAAG AGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGTCCTGAGAGCTGGAGGAGAAAGGATTCT ATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGATCAAGACACCAAAGCTACAGGATTCTGG AACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTAATCACAGACCTGGAGGAGCAGCTAAACCAGCT GACCGAGGACAACGCTGAACTCAACAACCAAAACTTCTACTTGTCCAAACAACTCGATGAGGCTTCTGGCGCCAACGACGAGATTGTACA ACTGCGAAGTGAAGTGGACCATCTCCGCCGGGAGATCACGGAACGAGAGATGCAGCTTACCAGCCAGAAGCAAACGATGGAGGCTCTGAA GACCACGTGCACCATGCTGGAGGAACAGGTCATGGATTTGGAGGCCCTAAACGATGAGCTGCTAGAAAAAGAGCGGCAGTGGGAGGCCTG GAGGAGCGTCCTGGGTGATGAGAAATCCCAGTTTGAGTGTCGGGTTCGAGAGCTGCAGAGAATGCTGGACACCGAGAAACAGAGCAGGGC GAGAGCCGATCAGCGGATCACCGAGTCTCGCCAGGTGGTGGAGCTGGCAGTGAAGGAGCACAAGGCTGAGATTCTCGCTCTGCAGCAGGC TCTCAAAGAGCAGAAGCTGAAGGCCGAGAGCCTCTCTGACAAGCTCAATGACCTGGAGAAGAAGCATGCTATGCTTGAAATGAATGCCCG AAGCTTACAGCAGAAGCTGGAGACTGAACGAGAGCTCAAACAGAGGCTTCTGGAAGAGCAAGCCAAATTACAGCAGCAGATGGACCTGCA GAAAAATCACATTTTCCGTCTGACTCAAGGACTGCAAGAAGCTCTAGATCGGGCTGATCTACTGAAGACAGAAAGAAGTGACTTGGAGTA TCAGCTGGAAAACATTCAGGTTCTCTATTCTCATGAAAAGGTGAAAATGGAAGGCACTATTTCTCAACAAACCAAACTCATTGATTTTCT GCAAGCCAAAATGGACCAACCTGCTAAAAAGAAAAAGGGTTTATTTAGTCGACGGAAAGAGGACCCTGCTTTACCCACACAGGTTCCTCT GCAGTACAATGAGCTGAAGCTGGCCCTGGAGAAGGAGAAAGCTCGCTGTGCAGAGCTAGAGGAAGCCCTTCAGAAGACCCGCATCGAGCT CCGGTCCGCCCGGGAGGAAGCTGCCCACCGCAAAGCAACGGACCACCCACACCCATCCACGCCAGCCACCGCGAGGCAGCAGATCGCCAT GTCCGCCATCGTGCGGTCGCCAGAGCACCAGCCCAGTGCCATGAGCCTGCTGGCCCCGCCATCCAGCCGCAGAAAGGAGTCTTCAACTCC AGAGGAATTTAGTCGGCGTCTTAAGGAACGCATGCACCACAATATTCCTCACCGATTCAACGTAGGACTGAACATGCGAGCCACAAAGTG TGCTGTGTGTCTGGATACCGTGCACTTTGGACGCCAGGCATCCAAATGTCTCGAATGTCAGGTGATGTGTCACCCCAAGTGCTCCACGTG CTTGCCAGCCACCTGCGGCTTGCCTGCTGAATATGCCACACACTTCACCGAGGCCTTCTGCCGTGACAAAATGAACTCCCCAGGTCTCCA GACCAAGGAGCCCAGCAGCAGCTTGCACCTGGAAGGGTGGATGAAGGTGCCCAGGAATAACAAACGAGGACAGCAAGGCTGGGACAGGAA GTACATTGTCCTGGAGGGATCAAAAGTCCTCATTTATGACAATGAAGCCAGAGAAGCTGGACAGAGGCCGGTGGAAGAATTTGAGCTGTG CCTTCCCGACGGGGATGTATCTATTCATGGTGCCGTTGGTGCTTCCGAACTCGCAAATACAGCCAAAGCAGATGTCCCATACATACTGAA GATGGAATCTCACCCGCACACCACCTGCTGGCCCGGGAGAACCCTCTACTTGCTAGCTCCCAGCTTCCCTGACAAACAGCGCTGGGTCAC CGCCTTAGAATCAGTTGTCGCAGGTGGGAGAGTTTCTAGGGAAAAAGCAGAAGCTGATGCTAAACTGCTTGGAAACTCCCTGCTGAAACT GGAAGGTGATGACCGTCTAGACATGAACTGCACGCTGCCCTTCAGTGACCAGGTGGTGTTGGTGGGCACCGAGGAAGGGCTCTACGCCCT GAATGTCTTGAAAAACTCCCTAACCCATGTCCCAGGAATTGGAGCAGTCTTCCAAATTTATATTATCAAGGACCTGGAGAAGCTACTCAT GATAGCAGGAGAAGAGCGGGCACTGTGTCTTGTGGACGTGAAGAAAGTGAAACAGTCCCTGGCCCAGTCCCACCTGCCTGCCCAGCCCGA CATCTCACCCAACATTTTTGAAGCTGTCAAGGGCTGCCACTTGTTTGGGGCAGGCAAGATTGAGAACGGGCTCTGCATCTGTGCAGCCAT GCCCAGCAAAGTCGTCATTCTCCGCTACAACGAAAACCTCAGCAAATACTGCATCCGGAAAGAGATAGAGACCTCAGAGCCCTGCAGCTG TATCCACTTCACCAATTACAGTATCCTCATTGGAACCAATAAATTCTACGAAATCGACATGAAGCAGTACACGCTCGAGGAATTCCTGGA TAAGAATGACCATTCCTTGGCACCTGCTGTGTTTGCCGCCTCTTCCAACAGCTTCCCTGTCTCAATCGTGCAGGTGAACAGCGCAGGGCA GCGAGAGGAGTACTTGCTGTGTTTCCACGAATTTGGAGTGTTCGTGGATTCTTACGGAAGACGTAGCCGCACAGACGATCTCAAGTGGAG TCGCTTACCTTTGGCCTTTGCCTACAGAGAACCCTATCTGTTTGTGACCCACTTCAACTCACTCGAAGTAATTGAGATCCAGGCACGCTC CTCAGCAGGGACCCCTGCCCGAGCGTACCTGGACATCCCGAACCCGCGCTACCTGGGCCCTGCCATTTCCTCAGGAGCGATTTACTTGGC GTCCTCATACCAGGATAAATTAAGGGTCATTTGCTGCAAGGGAAACCTCGTGAAGGAGTCCGGCACTGAACACCACCGGGGCCCGTCCAC CTCCCGCAGCAGCCCCAACAAGCGAGGCCCACCCACGTACAACGAGCACATCACCAAGCGCGTGGCCTCCAGCCCAGCGCCGCCCGAAGG CCCCAGCCACCCGCGAGAGCCAAGCACACCCCACCGCTACCGCGAGGGGCGGACCGAGCTGCGCAGGGACAAGTCTCCTGGCCGCCCCCT GGAGCGAGAGAAGTCCCCCGGCCGGATGCTCAGCACGCGGAGAGAGCGGTCCCCCGGGAGGCTGTTTGAAGACAGCAGCAGGGGCCGGCT GCCTGCGGGAGCCGTGAGGACCCCGCTGTCCCAGGTGAACAAGGTCTGGGACCAGTCTTCAGTATAAATCTCAGCCAGAAAAACCAACTC CTCATCTTGATCTGCAGGAAAACACCAAACACACTATGGAACTCTGCTGATGGGGACCCAAGCGCCCACGTGCTCAGCCACCCTCTGGCT CAGCGGGGCCCAGACCCACCTCGGCACGGACACCCCTGTCTCCAGGAGGGGCAGGTGGCTGAGGCTCTTCGGAGCTGTCAGCGCCCGGTG CCTGCCCTGGGCACCTCCCTGCAGTCATCTCTTTGCACTTTGTTACTCTTTCAAAGCATTCACAAACTTTTGTACCTAGCTCTAGCCTGT ACCAGTTAGTTCATCAAAGGAAACCAACCGGGATGCTAACTACAACATGGTTAGAATCCTAATTAGCTACTTTAAGATCCTAGGATTGGT TGGTTTTTCTTTTTTTTTTCTCTTTGTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAGACAACAGAATTCTTAATAGATTTGAATAGCGAC GTATTTCCTGTTGTAGTCATTTTTAGCTCGACCACATCATCAGGTCTTTGCCACCGAGGCATAGTGTAGAACAGTCCCGGTCAGTTGGCC AACCTCCCGCAGCCAAGTAGGTTCATCCTTGTTCCTGTTCATTCTCATAGATGGCCCTGCTTTCCCCAGGGTGACATCGTAGCCAAATGT TTACTGTTTTCATTGCCTTTTATGGCCTTGACGACTTCCCCTCCCACCAGCTGAGAATGTATGGAGGTCATCGGGGCCTCAGCTCGGAGG CAGTGACTTGGGGCCAAGGGACCTCGAGACGCTTTCCTTCCCCACCCCCCAGCGTCATCTCCCCAGCCTGCTGTTCCCGCTTTCCATATA GCTTTGGCCAGGAAAGCATGCAATAGACTTGCTCGGAGCCCAGCACTCCTGGGTCTCGGGGTCGGGGAGGGGACGGGGGCACCCACTTCC TTGTCTGTGACGGCGTGTTGTTCCCCACTCTGGGATGGGGAAGAGGCCCGTCGGGAGTTCTGCATGGCAGTTCACTGCATGTGCTGCCCC CTTGGGTTGCTCTGCCAATGTATTAATACCATCCCATAGCTCCTGCCAAATCGAGACCCTCTGACGACTTGCCGACTAACTGGCCACCAC AAGCTGCAGTCTGTAGCACTGAACAAACAAAAAACAAAACGCTCAAGCCTTACGACCAGAGAAGGATTTCAGCAAACCACCACCTCCCAC TCAGTGTCCCCTCCAAACTTCACACTTCCCTGCCTGCAGAGGATGACTCTGTTCACACCCAATCCAGCGCGGTTCTACCCCACGAAACTG TGACTTTCCAAATGAGCCTTTCCCTAGGGCTAGACCTAAGACCAGGAAGTTTGAGAAAGCAGCCGCAGCTCAACTCTTCCAGCTCCGCCA GGGTTGGGAAGTCCTTAGGTGCAGTGCGGCTCCCACTGGGTCTGCGGACCCTCCTATTAGAGTACGAAATTCCTGGCAACTGGTACAGAA CCAACCTAGAGGCTTTGCAGTTGGCAAGCTAACTCGCGGCCTTATTTCTGCCTTTAATCTCCCACAAGGCATCTGTTGCTTTGGGTCCTC CACGACTCTTAGGCCCGCCTCAACAACCCAGGCACCTCCTAGGTAGGCTCAAAGGTAGACCCGTTTCCACCGCAGCAGGTGAACATGACC GTGTTTTCAACTGTGTCCACAGTTCAGATCCCTTTCCAGATTGCAACCTGGCCTGCATCCCAGCTCCTTCCTGCTCGTGTCTTAACCTAA GTGCTTTCTTGTTTGAAACGCCTACAAACCTCCATGTGGTAGCTCCTTTGGCAAATGTCCTGCTGTGGCGTTTTATGTGTTGCTTGGAGT CTGTGGGGTCGTACTCCCTCCCCTCCCGTCCCCAGGGCAGATTTGATTGAATGTTTGCTGAAGTTTTGTCTCTTGGTCCACAGTATTTGG AAAGGTCACTGAAAATGGGTCTTTCAGTCTTGGCATTTCATTTAGGATCTCCATGAGAAATGGGCTTCTTGAGCCCTGAAAATGTATATT GTGTGTCTCATCTGTGAACTGCTTTCTGCTATATAGAACTAGCTCAAAAGACTGTACATATTTACAAGAAACTTTATATTCGTAAAAAAA AAAAGAGGAAATTGAATTGGTTTCTACTTTTTTATTGTAAAAGGTGCATTTTTCAACACTTACTTTTGGTTTCAATGGTGGTAGTTGTGG ACAGCCATCTTCACTGGAGGGTGGGGAGCTCCGTGTGACCACCAAGATGCCAGCAGGATATACCGTAACACGAAATTGCTGTCAAAAGCT TATTAGCATCAATCAAGATTCTAGGTCTCCAAAAGTACAGGCTTTTTCTTCATTACCTTTTTTATTCAGAACGAGGAAGAGAACACAAGG >In-frame_ENST00000361409_ENST00000261833_TCGA-09-0369_ARHGEF11_chr1_157014090_-_CIT_chr12_120173162_length(amino acids)=1140AA_start in transcript=604_stop in transcript=4026 MRAGGERILSSSWEALLSPCSKIASDSILIKTPKLQDSGTVETPRNHECKVTPEYRQVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA SGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM LDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA KLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKED PALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPS SRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCR DKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTA KADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLV GTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIE NGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVS IVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPA ISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELR -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ARHGEF11-CIT |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000261833 | 22 | 47 | 1091_1302 | 944.0 | 2028.0 | Rho/Rac | |
| Tgene | CIT | chr1:157014090 | chr12:120173162 | ENST00000392521 | 23 | 48 | 1091_1302 | 986.0 | 2070.0 | Rho/Rac |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARHGEF11-CIT |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARHGEF11-CIT |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ARHGEF11 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | CIT | C4310723 | MICROCEPHALY 17, PRIMARY, AUTOSOMAL RECESSIVE | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Tgene | CIT | C3711387 | Autosomal Recessive Primary Microcephaly | 1 | ORPHANET |
| Tgene | CIT | C3809431 | MICROCEPHALY 11, PRIMARY, AUTOSOMAL RECESSIVE | 1 | GENOMICS_ENGLAND |
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