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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PCNXL3-PACS1 (FusionGDB2 ID:63079)

Fusion Gene Summary for PCNXL3-PACS1

check button Fusion gene summary
Fusion gene informationFusion gene name: PCNXL3-PACS1
Fusion gene ID: 63079
HgeneTgene
Gene symbol

PCNXL3

PACS1

Gene ID

399909

55690

Gene namepecanex 3phosphofurin acidic cluster sorting protein 1
SynonymsPCNXL3MRD17|SHMS
Cytomap

11q13.1

11q13.1-q13.2

Type of geneprotein-codingprotein-coding
Descriptionpecanex-like protein 3pecanex homolog 3pecanex homolog protein 3pecanex-like 3phosphofurin acidic cluster sorting protein 1PACS-1cytosolic sorting protein PACS-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000355703, ENST00000531280, 
ENST00000320580, ENST00000529757, 
ENST00000524815, 
Fusion gene scores* DoF score10 X 9 X 8=72021 X 18 X 12=4536
# samples 1026
** MAII scorelog2(10/720*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/4536*10)=-4.12483711191377
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCNXL3 [Title/Abstract] AND PACS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPCNXL3(65391115)-PACS1(66006274), # samples:1
PCNXL3(65391115)-PACS1(66006275), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PCNXL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PACS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-LA-A7SWPCNXL3chr11

65391115

+PACS1chr11

66006274

+
ChimerDB4LUSCTCGA-LA-A7SWPCNXL3chr11

65391115

+PACS1chr11

66006275

+


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Fusion Gene ORF analysis for PCNXL3-PACS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000355703ENST00000320580PCNXL3chr11

65391115

+PACS1chr11

66006274

+
In-frameENST00000355703ENST00000529757PCNXL3chr11

65391115

+PACS1chr11

66006274

+
5CDS-intronENST00000355703ENST00000524815PCNXL3chr11

65391115

+PACS1chr11

66006274

+
intron-3CDSENST00000531280ENST00000320580PCNXL3chr11

65391115

+PACS1chr11

66006274

+
intron-3CDSENST00000531280ENST00000529757PCNXL3chr11

65391115

+PACS1chr11

66006274

+
intron-intronENST00000531280ENST00000524815PCNXL3chr11

65391115

+PACS1chr11

66006274

+
In-frameENST00000355703ENST00000320580PCNXL3chr11

65391115

+PACS1chr11

66006275

+
In-frameENST00000355703ENST00000529757PCNXL3chr11

65391115

+PACS1chr11

66006275

+
5CDS-intronENST00000355703ENST00000524815PCNXL3chr11

65391115

+PACS1chr11

66006275

+
intron-3CDSENST00000531280ENST00000320580PCNXL3chr11

65391115

+PACS1chr11

66006275

+
intron-3CDSENST00000531280ENST00000529757PCNXL3chr11

65391115

+PACS1chr11

66006275

+
intron-intronENST00000531280ENST00000524815PCNXL3chr11

65391115

+PACS1chr11

66006275

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355703PCNXL3chr1165391115+ENST00000320580PACS1chr1166006274+5159305037436911105
ENST00000355703PCNXL3chr1165391115+ENST00000529757PACS1chr1166006274+3694305037436911105
ENST00000355703PCNXL3chr1165391115+ENST00000320580PACS1chr1166006275+5159305037436911105
ENST00000355703PCNXL3chr1165391115+ENST00000529757PACS1chr1166006275+3694305037436911105

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355703ENST00000320580PCNXL3chr1165391115+PACS1chr1166006274+0.0066011310.9933989
ENST00000355703ENST00000529757PCNXL3chr1165391115+PACS1chr1166006274+0.0125912380.98740876
ENST00000355703ENST00000320580PCNXL3chr1165391115+PACS1chr1166006275+0.0066011310.9933989
ENST00000355703ENST00000529757PCNXL3chr1165391115+PACS1chr1166006275+0.0125912380.98740876

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Fusion Genomic Features for PCNXL3-PACS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PCNXL3chr1165391115+PACS1chr1166006274+7.35E-050.99992645
PCNXL3chr1165391115+PACS1chr1166006274+7.35E-050.99992645

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PCNXL3-PACS1


check button Go to

FGviewer for the breakpoints of chr11:65391115-chr11:66006274

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+1235425_458837.02035.0Compositional biasNote=Ser-rich
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+1235809_812837.02035.0Compositional biasNote=Poly-Leu
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+1235425_458837.02035.0Compositional biasNote=Ser-rich
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+1235809_812837.02035.0Compositional biasNote=Poly-Leu
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+123533_53837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+123554_74837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+1235790_812837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+1235819_836837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+123533_53837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+123554_74837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+1235790_812837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+1235819_836837.02035.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+12351427_1430837.02035.0Compositional biasNote=Poly-Cys
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+12351824_1959837.02035.0Compositional biasNote=Gly-rich
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+12351427_1430837.02035.0Compositional biasNote=Poly-Cys
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+12351824_1959837.02035.0Compositional biasNote=Gly-rich
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+12351053_1073837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+12351078_1098837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+12351244_1264837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+12351280_1300837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+1235852_872837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+1235880_900837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+1235903_923837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+1235946_968837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006274ENST00000355703+1235980_1000837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+12351053_1073837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+12351078_1098837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+12351244_1264837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+12351280_1300837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+1235852_872837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+1235880_900837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+1235903_923837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+1235946_968837.02035.0TransmembraneHelical
HgenePCNXL3chr11:65391115chr11:66006275ENST00000355703+1235980_1000837.02035.0TransmembraneHelical
TgenePACS1chr11:65391115chr11:66006274ENST000003205801824353_377750.0964.0Coiled coilOntology_term=ECO:0000255
TgenePACS1chr11:65391115chr11:66006275ENST000003205801824353_377750.0964.0Coiled coilOntology_term=ECO:0000255
TgenePACS1chr11:65391115chr11:66006274ENST000003205801824112_115750.0964.0Compositional biasNote=Poly-Ser
TgenePACS1chr11:65391115chr11:66006274ENST000003205801824279_283750.0964.0Compositional biasNote=Poly-Glu
TgenePACS1chr11:65391115chr11:66006274ENST00000320580182435_40750.0964.0Compositional biasNote=Poly-Gln
TgenePACS1chr11:65391115chr11:66006274ENST00000320580182455_84750.0964.0Compositional biasNote=Ser-rich
TgenePACS1chr11:65391115chr11:66006274ENST0000032058018245_44750.0964.0Compositional biasNote=Gly-rich
TgenePACS1chr11:65391115chr11:66006274ENST00000320580182462_65750.0964.0Compositional biasNote=Poly-Ala
TgenePACS1chr11:65391115chr11:66006275ENST000003205801824112_115750.0964.0Compositional biasNote=Poly-Ser
TgenePACS1chr11:65391115chr11:66006275ENST000003205801824279_283750.0964.0Compositional biasNote=Poly-Glu
TgenePACS1chr11:65391115chr11:66006275ENST00000320580182435_40750.0964.0Compositional biasNote=Poly-Gln
TgenePACS1chr11:65391115chr11:66006275ENST00000320580182455_84750.0964.0Compositional biasNote=Ser-rich
TgenePACS1chr11:65391115chr11:66006275ENST0000032058018245_44750.0964.0Compositional biasNote=Gly-rich
TgenePACS1chr11:65391115chr11:66006275ENST00000320580182462_65750.0964.0Compositional biasNote=Poly-Ala
TgenePACS1chr11:65391115chr11:66006274ENST000003205801824168_175750.0964.0RegionNote=Involved in binding to AP-1
TgenePACS1chr11:65391115chr11:66006275ENST000003205801824168_175750.0964.0RegionNote=Involved in binding to AP-1


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Fusion Gene Sequence for PCNXL3-PACS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000355703_ENST00000320580_TCGA-LA-A7SW_PCNXL3_chr11_65391115_+_PACS1_chr11_66006274_length(transcript)=5159nt_BP=3050nt
GGCGCATGCGCCACTGCAGGCTGGCGGTTCGCGGCTCCTTCTTCCGGCCTCCTCCTTAGGCCGGCACCAGCAGAAGCCGGGCGAGCGCGG
AGCCCCAAGCAAGTGACCTGCGACCCCGAAAGTGGACCCCAGATCCTGGGGTTCTCCCTGGTCCGGAGACTAGGGAGCTGTCGCCTGCAC
CCCGGGAGCACCCACCCCACGACCACCTCTGGATGCCGCCGACGGGTACCCGGCCCGTGCCCCGCGCCTGCCTGCCGGCTCGGCCCCTCG
GAGCAATTCTGGGCCAGGAGTGGGGACCCGGACCCCGCCCCTGATGCAGCCCCACCCCCGCGTCCGGGCCTTGCACCACTGACTGTCCCG
GCCGGCCCCGCCCCCTGCTCGCACCCTCGCGCGGCCGAGCCCCCCTCCCCCGCTGGGGGAGGCCATGGCGTGAGCGTGAGGCCGGGCCCC
GGGGCCCTCAGGCGCCAGACGGGGCATGGGCCGGGGGCCGCCCCCATGAGGGTCCCGGGAGGGGGGGCGCGGGCAGCAGCGGCGGGGCCA
TGGGGTCGCAGGTGTTGCAGATCCTGCGCCAGGGGGTGTGGGCCTCGCTCACCGGCGGTTGGTTCTTCGACCCGCACCAGAGCACCTTCT
CCAACTGCTTCCACCTCTATGTGTGGATCTTCCTGCTCATCTTTCCCTTCTTACTGTACATGGTCCTGCCTCCCAGCTTGATGGTGGCCG
GCGTGTACTGCCTCGTGGTGGCTGTCATCTTTGCTACTATCAAGACTGTCAATTATCGGCTTCATGCCATGTTTGACCAGGGCGAGATCG
TGGAGAAGCGCAGCTCTACCATGGGGGAGCTGGAGGAAGAGCCTGCCCAGGGGGACAGCAATCCACCCAGGGACCCCGGAGTGGAGATGA
CAGTGTTCCGGAAAGTCAGTTCCACACCCCCGGTGCGCTGCAGCTCCCAGCACTCTGTGTTTGGCTTCAACCAGGTCTCGGAGCTGCTGC
CCCGAATGGAGGACTCTGGGCCCCTTAGAGACATCAAGGAGCTGGTGCGGGAGCAGGGCAGCAACAATGTGATCGTGACTTCTGCCGACC
GAGAGATGCTGAAGCTCAGCTCGCAGGAGAAACTGATTGGAGACCTTCCCCAGACGCCTCCAGGGGCTGTCCCAGACCCCTCTCTTGCCA
GTACAGACTCTTCAGAGCCTTCTCCCCTGGCTGGAGATGGAGCGCCCTGGAGTGGGAGCAGCATGGCTGACACTCCCATGAGCCCCCTGC
TGAAGGGGAGCCTCAGCCAGGAGCTGAGCAAGAGCTTCCTGACCCTGACCCAGCCTGACCGGGCCCTGGTGAGGACCAGCAGTCGACGGG
AACAACGCAGGGGGGCAGGTGGCTATCAGCCCCTTGACCGGCGGGGCTCAGGGGAGCCCACGCCCCAGAAAGCCGGCTCCTCAGACTCCT
GCTTCAGCGGCACTGACAGGGAGACATTGAGCAGCTTCAAGAGTGAGAAGACCAACTCCACCCATCTGGACAGCCCCCCAGGGGGGCCAG
CCCCTGAGGGCAGCGACACAGACCCACCCTCTGAGGCTGAGCTGCCTGCCTCACCAGACGCCGGGGTCCCCTCAGATGACACGCTGCGTT
CCTTTGACACGGTCATTGGAGCAGGGACGCCACCGGGCCTGGCTGAGCCGCTCCTGGTCGTGCGGCCCAAGGACTTGGCCCTGCTACGGC
CTAGCAAACGGCAGCCACCCCTGCGAAGACACTCTCCACCTGGCCGTGCCCCTCGACGGCCCCTGCTTGAAGGTGGGGGCTTCTTTGAGG
ATGAAGACACTAGTGAGGGCAGTGAACTGAGCCCGGCCTCCAGTCTCCGATCGCAGCGCCGCTACAGTACTGACAGCTCCTCTTCTACTT
CCTGCTACTCCCCTGAGAGCTCCCGGGGTGCAGCAGGGGGACCCCGGAAGCGGAGGGCCCCCCATGGGGCTGAGGAGGGAACTGCTGTGC
CCCCCAAGCGGCCATATGGGACCCAGCGGACGCCTAGTACCGCCAGCGCTAAAACACATGCCCGTGTGCTGAGCATGGATGGGGCTGGGG
GTGATGTTCTGAGGCCCCCACTGGCTGGCTGCAAGGCAGAGCTGGAGGCCCAGGTTGGGGTGGAGCAGGCTGCTAGTGAGCCTGTTGTGC
TGCCTGCTGAGGCGCGAAGGGGACCCGCTGCCAACCAGCCCGGCTGGCGGGGGGAGCTGCAGGAGGAAGGTGCTGTGGGGGGAGCGGCCG
AGGAGACTGGCAGGCGGGACCGCTCAAGCAGTGTGAGGCGGACCCAGGCCATTCGGAGACGCCACAATGCAGGCAGCAACCCCACCCCTC
CAGCCTCTGTCATGGGCTCGCCGCCCAGCAGCCTGCAGGAAGCTCAGCGGGGCCGGGCTGCCTCCCACTCCCGGGCGCTGACGCTGCCCT
CTGCGCTGCATTTCGCCTCTTCACTGTTGCTCACCCGGGCCGGTGCCAATGTGCATGAGGCCTGCACCTTTGATGACACTTCTGAGGGTG
CTGTGCACTATTTCTACGATGAGAGCGGTGTGCGGCGTTCCTACACCTTTGGCCTGGCTGGAGGCGGCTACGAGAACCCTGTAGGGCAGC
AAGGGGAGCAGACAGCTAATGGAGCCTGGGACCGACACTCGCATTCCTCCAGCTTCCACTCGGCTGATGTCCCTGAGGCTACAGGCGGCC
TGAACCTGCTGCAGCCGAGGCCTGTGGTTCTGCAGGGCATGCAGGTGCGCCGGGTGCCCCTGGAGATCCCGGAGGAGCAGACACTGATGG
AAGAAGCGCCACCCCGGGCCCAGCATAGTTACAAGTACTGGCTTCTCCCTGGCCGCTGGACCTCTGTGCGCTATGAGCGGCTTGCCCTGC
TGGCTCTGCTGGACCGGACGCGGGGAGTGCTGGAGAACATCTTCGGCGTGGGCCTGAGCAGCCTTGTGGCCTTCCTGGGCTACCTGCTGC
TGCTCAAGGGCTTCTTCACTGACATCTGGGTCTTCCAGTTCTGCCTGGTCATCGCCTCCTGCCAGTACTCCTTGCTGAAGGTGGTGAAGG
TGGGTCTGGTTGAAGACTCTCCCTCCACAGCAGGCGATGGGGACGATTCTCCTGTGGTCAGCCTTACTGTGCCCTCCACATCACCACCCT
CCAGCTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCCTCCCCATCTATGAGCAGCGCCCTGGCCATCGTGGGGAGCCCTAATA
GCCCATATGGGGACGTGATTGGCCTCCAGGTGGACTACTGGCTGGGCCACCCCGGGGAGCGGAGGAGGGAAGGCGACAAGAGGGACGCCA
GCTCGAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTGTCCCGCCTGCCCCATAGTGGGGAGGCCCAGCTTTCTGGCACCATGG
CCATGACTGTGGTCACCAAAGAAAAGAACAAGAAAGTTCCCACCATCTTCCTGAGCAAGAAACCCCGAGAAAAGGAGGTGGATTCTAAGA
GCCAGGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAGCAGCAGCAGACTATGCTGAGAGTGTCCATCGATGGGGTCGAGTGGA
GTGACATCAAGTTCTTCCAGCTGGCAGCCCAGTGGCCCACCCATGTCAAGCACTTTCCAGTGGGACTCTTCAGTGGCAGCAAGGCCACCT
GAGGCCCTGTCTCCCAGCCACTTTCCCTCCTGGCACTGCCACCAGCCTCACCGCCTGCGGGCAGGGGGAGGCCAGCAGGCCCGGGCCCAG
CACCCCTTCCCTGGCACCAGGGTCTGCCTCTCACTCGCCCAGGTCCCGAAGGACACTGCCACAGGGACGCCTTCCCTCCCCTCCCCTCCA
GCCCACCCCTGCACAGCCCCTCCTCCTTCCCGCTTTTCCCCTTCTCCCTCCTGCTCCAGGCCCAAGGCGTGTTGGTTTTGCCTTCTGGTG
CCCATAGTCCCCTGGACTGAGTCCCCCAGGCCTTCCTTCACCCGACTTCCAAACTCTTCCTTGTGGTATCAGTTTCCTTCTCGGAAATGA
GAAAGCTGGAATCCTGGTCCCCAGCAGGAGAGCCTAGTCCTCCCCCAGCCCCTCCAGCCACCAGGGTGTCCTCTAGGATGCAGCTGCCAG
ATCCACTCACTCTGCTGCCTCCAGCAGGACCCAAGGCCACTTTCAACTCTTATGGGGTTCTCCACCTGCCCCAGAGCTTCTCAAGGGAGG
GTAAGGGGGCACCCTGAGCCCACAGGACCCCTACTTCACAGCTCACAGGGGCAGGAGGCAGCTCCCCTGCCTCCAGGACCCTGTTGCTAT
GGTGACACAGCGTTTCTAGGACAGAGGGGCCTCCCAGTCTCCCCCCACCACCCGTGCACGACTTCCTCACCACCCCCAGGTTCCCTGCAG
ATGTCGTGTGTGTCCTGAGTGTTTCTTTGGTTCTTTGCACGCCAAGTCTCTTGGTTGTACCATGTGACACACCCTGTGCACTGGTCGCTG
TCTTCGTGGCTTCCACCCTTGTTAATGATGCTCCTGCCTCTGCCTCCCAGCCCCTCACCCAGCACAGCTCTGCCTGGACTTGGAGAGATG
GGAGGCAGACCCCCACCACCATACATGCTGTCTGTGGCCCCTCAGACATTCTGTTTCATCTCCCATTCATCTCCCTCCTCCCACCGTGTC
AGTTTTTCTGCCTTTCCCTGCTCTGTTCTTCCCCCTCCTTAGGCCCCAGCCTGGGCCCAGACCCATCCTCCCAGCCAGGTTTCCCTCCAG
CAGGCTCCTTCCCTCCCTGTCACCTCCCTCTCACCAACCCGGGGTCTGAGCCCCTCATTCCTGACCGTCCGTGTTCTCAGGAGTGGTTGA
GGACACAGGGCCCCAGCCCAGCCCTCTGCACCCCCCAGCCCGGCCATCTGCGCCCCACAGCCCCTTTGGAGCTTTTCTCTTGTCCTCTCA
CTCCTTCCCAGAAGTTTTTGCACAGAACTTCATTTTGAAAGTGTTTTTCTCATTCTCCATACCTCCCCCAAGCTCTCCTCCAGCCCTTCC
CAGGGCTCAGCCCTGCTGTCCTGAGCGTCTCCTGGGCCAGAGAGAGGAGATGGGGGTGGGAGGGACTGAGTTGATGTTGGGTTTTTCATT

>In-frame_ENST00000355703_ENST00000320580_TCGA-LA-A7SW_PCNXL3_chr11_65391115_+_PACS1_chr11_66006274_length(amino acids)=1105AA_start in transcript=374_stop in transcript=3691
MLAPSRGRAPLPRWGRPWREREAGPRGPQAPDGAWAGGRPHEGPGRGGAGSSGGAMGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFH
LYVWIFLLIFPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRSSTMGELEEEPAQGDSNPPRDPGVEMTVFRK
VSSTPPVRCSSQHSVFGFNQVSELLPRMEDSGPLRDIKELVREQGSNNVIVTSADREMLKLSSQEKLIGDLPQTPPGAVPDPSLASTDSS
EPSPLAGDGAPWSGSSMADTPMSPLLKGSLSQELSKSFLTLTQPDRALVRTSSRREQRRGAGGYQPLDRRGSGEPTPQKAGSSDSCFSGT
DRETLSSFKSEKTNSTHLDSPPGGPAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVIGAGTPPGLAEPLLVVRPKDLALLRPSKRQ
PPLRRHSPPGRAPRRPLLEGGGFFEDEDTSEGSELSPASSLRSQRRYSTDSSSSTSCYSPESSRGAAGGPRKRRAPHGAEEGTAVPPKRP
YGTQRTPSTASAKTHARVLSMDGAGGDVLRPPLAGCKAELEAQVGVEQAASEPVVLPAEARRGPAANQPGWRGELQEEGAVGGAAEETGR
RDRSSSVRRTQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAASHSRALTLPSALHFASSLLLTRAGANVHEACTFDDTSEGAVHYF
YDESGVRRSYTFGLAGGGYENPVGQQGEQTANGAWDRHSHSSSFHSADVPEATGGLNLLQPRPVVLQGMQVRRVPLEIPEEQTLMEEAPP
RAQHSYKYWLLPGRWTSVRYERLALLALLDRTRGVLENIFGVGLSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKVVKVGLVE
DSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNT
LKSVFRSVQVSRLPHSGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKF

--------------------------------------------------------------
>In-frame_ENST00000355703_ENST00000529757_TCGA-LA-A7SW_PCNXL3_chr11_65391115_+_PACS1_chr11_66006274_length(transcript)=3694nt_BP=3050nt
GGCGCATGCGCCACTGCAGGCTGGCGGTTCGCGGCTCCTTCTTCCGGCCTCCTCCTTAGGCCGGCACCAGCAGAAGCCGGGCGAGCGCGG
AGCCCCAAGCAAGTGACCTGCGACCCCGAAAGTGGACCCCAGATCCTGGGGTTCTCCCTGGTCCGGAGACTAGGGAGCTGTCGCCTGCAC
CCCGGGAGCACCCACCCCACGACCACCTCTGGATGCCGCCGACGGGTACCCGGCCCGTGCCCCGCGCCTGCCTGCCGGCTCGGCCCCTCG
GAGCAATTCTGGGCCAGGAGTGGGGACCCGGACCCCGCCCCTGATGCAGCCCCACCCCCGCGTCCGGGCCTTGCACCACTGACTGTCCCG
GCCGGCCCCGCCCCCTGCTCGCACCCTCGCGCGGCCGAGCCCCCCTCCCCCGCTGGGGGAGGCCATGGCGTGAGCGTGAGGCCGGGCCCC
GGGGCCCTCAGGCGCCAGACGGGGCATGGGCCGGGGGCCGCCCCCATGAGGGTCCCGGGAGGGGGGGCGCGGGCAGCAGCGGCGGGGCCA
TGGGGTCGCAGGTGTTGCAGATCCTGCGCCAGGGGGTGTGGGCCTCGCTCACCGGCGGTTGGTTCTTCGACCCGCACCAGAGCACCTTCT
CCAACTGCTTCCACCTCTATGTGTGGATCTTCCTGCTCATCTTTCCCTTCTTACTGTACATGGTCCTGCCTCCCAGCTTGATGGTGGCCG
GCGTGTACTGCCTCGTGGTGGCTGTCATCTTTGCTACTATCAAGACTGTCAATTATCGGCTTCATGCCATGTTTGACCAGGGCGAGATCG
TGGAGAAGCGCAGCTCTACCATGGGGGAGCTGGAGGAAGAGCCTGCCCAGGGGGACAGCAATCCACCCAGGGACCCCGGAGTGGAGATGA
CAGTGTTCCGGAAAGTCAGTTCCACACCCCCGGTGCGCTGCAGCTCCCAGCACTCTGTGTTTGGCTTCAACCAGGTCTCGGAGCTGCTGC
CCCGAATGGAGGACTCTGGGCCCCTTAGAGACATCAAGGAGCTGGTGCGGGAGCAGGGCAGCAACAATGTGATCGTGACTTCTGCCGACC
GAGAGATGCTGAAGCTCAGCTCGCAGGAGAAACTGATTGGAGACCTTCCCCAGACGCCTCCAGGGGCTGTCCCAGACCCCTCTCTTGCCA
GTACAGACTCTTCAGAGCCTTCTCCCCTGGCTGGAGATGGAGCGCCCTGGAGTGGGAGCAGCATGGCTGACACTCCCATGAGCCCCCTGC
TGAAGGGGAGCCTCAGCCAGGAGCTGAGCAAGAGCTTCCTGACCCTGACCCAGCCTGACCGGGCCCTGGTGAGGACCAGCAGTCGACGGG
AACAACGCAGGGGGGCAGGTGGCTATCAGCCCCTTGACCGGCGGGGCTCAGGGGAGCCCACGCCCCAGAAAGCCGGCTCCTCAGACTCCT
GCTTCAGCGGCACTGACAGGGAGACATTGAGCAGCTTCAAGAGTGAGAAGACCAACTCCACCCATCTGGACAGCCCCCCAGGGGGGCCAG
CCCCTGAGGGCAGCGACACAGACCCACCCTCTGAGGCTGAGCTGCCTGCCTCACCAGACGCCGGGGTCCCCTCAGATGACACGCTGCGTT
CCTTTGACACGGTCATTGGAGCAGGGACGCCACCGGGCCTGGCTGAGCCGCTCCTGGTCGTGCGGCCCAAGGACTTGGCCCTGCTACGGC
CTAGCAAACGGCAGCCACCCCTGCGAAGACACTCTCCACCTGGCCGTGCCCCTCGACGGCCCCTGCTTGAAGGTGGGGGCTTCTTTGAGG
ATGAAGACACTAGTGAGGGCAGTGAACTGAGCCCGGCCTCCAGTCTCCGATCGCAGCGCCGCTACAGTACTGACAGCTCCTCTTCTACTT
CCTGCTACTCCCCTGAGAGCTCCCGGGGTGCAGCAGGGGGACCCCGGAAGCGGAGGGCCCCCCATGGGGCTGAGGAGGGAACTGCTGTGC
CCCCCAAGCGGCCATATGGGACCCAGCGGACGCCTAGTACCGCCAGCGCTAAAACACATGCCCGTGTGCTGAGCATGGATGGGGCTGGGG
GTGATGTTCTGAGGCCCCCACTGGCTGGCTGCAAGGCAGAGCTGGAGGCCCAGGTTGGGGTGGAGCAGGCTGCTAGTGAGCCTGTTGTGC
TGCCTGCTGAGGCGCGAAGGGGACCCGCTGCCAACCAGCCCGGCTGGCGGGGGGAGCTGCAGGAGGAAGGTGCTGTGGGGGGAGCGGCCG
AGGAGACTGGCAGGCGGGACCGCTCAAGCAGTGTGAGGCGGACCCAGGCCATTCGGAGACGCCACAATGCAGGCAGCAACCCCACCCCTC
CAGCCTCTGTCATGGGCTCGCCGCCCAGCAGCCTGCAGGAAGCTCAGCGGGGCCGGGCTGCCTCCCACTCCCGGGCGCTGACGCTGCCCT
CTGCGCTGCATTTCGCCTCTTCACTGTTGCTCACCCGGGCCGGTGCCAATGTGCATGAGGCCTGCACCTTTGATGACACTTCTGAGGGTG
CTGTGCACTATTTCTACGATGAGAGCGGTGTGCGGCGTTCCTACACCTTTGGCCTGGCTGGAGGCGGCTACGAGAACCCTGTAGGGCAGC
AAGGGGAGCAGACAGCTAATGGAGCCTGGGACCGACACTCGCATTCCTCCAGCTTCCACTCGGCTGATGTCCCTGAGGCTACAGGCGGCC
TGAACCTGCTGCAGCCGAGGCCTGTGGTTCTGCAGGGCATGCAGGTGCGCCGGGTGCCCCTGGAGATCCCGGAGGAGCAGACACTGATGG
AAGAAGCGCCACCCCGGGCCCAGCATAGTTACAAGTACTGGCTTCTCCCTGGCCGCTGGACCTCTGTGCGCTATGAGCGGCTTGCCCTGC
TGGCTCTGCTGGACCGGACGCGGGGAGTGCTGGAGAACATCTTCGGCGTGGGCCTGAGCAGCCTTGTGGCCTTCCTGGGCTACCTGCTGC
TGCTCAAGGGCTTCTTCACTGACATCTGGGTCTTCCAGTTCTGCCTGGTCATCGCCTCCTGCCAGTACTCCTTGCTGAAGGTGGTGAAGG
TGGGTCTGGTTGAAGACTCTCCCTCCACAGCAGGCGATGGGGACGATTCTCCTGTGGTCAGCCTTACTGTGCCCTCCACATCACCACCCT
CCAGCTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCCTCCCCATCTATGAGCAGCGCCCTGGCCATCGTGGGGAGCCCTAATA
GCCCATATGGGGACGTGATTGGCCTCCAGGTGGACTACTGGCTGGGCCACCCCGGGGAGCGGAGGAGGGAAGGCGACAAGAGGGACGCCA
GCTCGAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTGTCCCGCCTGCCCCATAGTGGGGAGGCCCAGCTTTCTGGCACCATGG
CCATGACTGTGGTCACCAAAGAAAAGAACAAGAAAGTTCCCACCATCTTCCTGAGCAAGAAACCCCGAGAAAAGGAGGTGGATTCTAAGA
GCCAGGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAGCAGCAGCAGACTATGCTGAGAGTGTCCATCGATGGGGTCGAGTGGA
GTGACATCAAGTTCTTCCAGCTGGCAGCCCAGTGGCCCACCCATGTCAAGCACTTTCCAGTGGGACTCTTCAGTGGCAGCAAGGCCACCT

>In-frame_ENST00000355703_ENST00000529757_TCGA-LA-A7SW_PCNXL3_chr11_65391115_+_PACS1_chr11_66006274_length(amino acids)=1105AA_start in transcript=374_stop in transcript=3691
MLAPSRGRAPLPRWGRPWREREAGPRGPQAPDGAWAGGRPHEGPGRGGAGSSGGAMGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFH
LYVWIFLLIFPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRSSTMGELEEEPAQGDSNPPRDPGVEMTVFRK
VSSTPPVRCSSQHSVFGFNQVSELLPRMEDSGPLRDIKELVREQGSNNVIVTSADREMLKLSSQEKLIGDLPQTPPGAVPDPSLASTDSS
EPSPLAGDGAPWSGSSMADTPMSPLLKGSLSQELSKSFLTLTQPDRALVRTSSRREQRRGAGGYQPLDRRGSGEPTPQKAGSSDSCFSGT
DRETLSSFKSEKTNSTHLDSPPGGPAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVIGAGTPPGLAEPLLVVRPKDLALLRPSKRQ
PPLRRHSPPGRAPRRPLLEGGGFFEDEDTSEGSELSPASSLRSQRRYSTDSSSSTSCYSPESSRGAAGGPRKRRAPHGAEEGTAVPPKRP
YGTQRTPSTASAKTHARVLSMDGAGGDVLRPPLAGCKAELEAQVGVEQAASEPVVLPAEARRGPAANQPGWRGELQEEGAVGGAAEETGR
RDRSSSVRRTQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAASHSRALTLPSALHFASSLLLTRAGANVHEACTFDDTSEGAVHYF
YDESGVRRSYTFGLAGGGYENPVGQQGEQTANGAWDRHSHSSSFHSADVPEATGGLNLLQPRPVVLQGMQVRRVPLEIPEEQTLMEEAPP
RAQHSYKYWLLPGRWTSVRYERLALLALLDRTRGVLENIFGVGLSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKVVKVGLVE
DSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNT
LKSVFRSVQVSRLPHSGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKF

--------------------------------------------------------------
>In-frame_ENST00000355703_ENST00000320580_TCGA-LA-A7SW_PCNXL3_chr11_65391115_+_PACS1_chr11_66006275_length(transcript)=5159nt_BP=3050nt
GGCGCATGCGCCACTGCAGGCTGGCGGTTCGCGGCTCCTTCTTCCGGCCTCCTCCTTAGGCCGGCACCAGCAGAAGCCGGGCGAGCGCGG
AGCCCCAAGCAAGTGACCTGCGACCCCGAAAGTGGACCCCAGATCCTGGGGTTCTCCCTGGTCCGGAGACTAGGGAGCTGTCGCCTGCAC
CCCGGGAGCACCCACCCCACGACCACCTCTGGATGCCGCCGACGGGTACCCGGCCCGTGCCCCGCGCCTGCCTGCCGGCTCGGCCCCTCG
GAGCAATTCTGGGCCAGGAGTGGGGACCCGGACCCCGCCCCTGATGCAGCCCCACCCCCGCGTCCGGGCCTTGCACCACTGACTGTCCCG
GCCGGCCCCGCCCCCTGCTCGCACCCTCGCGCGGCCGAGCCCCCCTCCCCCGCTGGGGGAGGCCATGGCGTGAGCGTGAGGCCGGGCCCC
GGGGCCCTCAGGCGCCAGACGGGGCATGGGCCGGGGGCCGCCCCCATGAGGGTCCCGGGAGGGGGGGCGCGGGCAGCAGCGGCGGGGCCA
TGGGGTCGCAGGTGTTGCAGATCCTGCGCCAGGGGGTGTGGGCCTCGCTCACCGGCGGTTGGTTCTTCGACCCGCACCAGAGCACCTTCT
CCAACTGCTTCCACCTCTATGTGTGGATCTTCCTGCTCATCTTTCCCTTCTTACTGTACATGGTCCTGCCTCCCAGCTTGATGGTGGCCG
GCGTGTACTGCCTCGTGGTGGCTGTCATCTTTGCTACTATCAAGACTGTCAATTATCGGCTTCATGCCATGTTTGACCAGGGCGAGATCG
TGGAGAAGCGCAGCTCTACCATGGGGGAGCTGGAGGAAGAGCCTGCCCAGGGGGACAGCAATCCACCCAGGGACCCCGGAGTGGAGATGA
CAGTGTTCCGGAAAGTCAGTTCCACACCCCCGGTGCGCTGCAGCTCCCAGCACTCTGTGTTTGGCTTCAACCAGGTCTCGGAGCTGCTGC
CCCGAATGGAGGACTCTGGGCCCCTTAGAGACATCAAGGAGCTGGTGCGGGAGCAGGGCAGCAACAATGTGATCGTGACTTCTGCCGACC
GAGAGATGCTGAAGCTCAGCTCGCAGGAGAAACTGATTGGAGACCTTCCCCAGACGCCTCCAGGGGCTGTCCCAGACCCCTCTCTTGCCA
GTACAGACTCTTCAGAGCCTTCTCCCCTGGCTGGAGATGGAGCGCCCTGGAGTGGGAGCAGCATGGCTGACACTCCCATGAGCCCCCTGC
TGAAGGGGAGCCTCAGCCAGGAGCTGAGCAAGAGCTTCCTGACCCTGACCCAGCCTGACCGGGCCCTGGTGAGGACCAGCAGTCGACGGG
AACAACGCAGGGGGGCAGGTGGCTATCAGCCCCTTGACCGGCGGGGCTCAGGGGAGCCCACGCCCCAGAAAGCCGGCTCCTCAGACTCCT
GCTTCAGCGGCACTGACAGGGAGACATTGAGCAGCTTCAAGAGTGAGAAGACCAACTCCACCCATCTGGACAGCCCCCCAGGGGGGCCAG
CCCCTGAGGGCAGCGACACAGACCCACCCTCTGAGGCTGAGCTGCCTGCCTCACCAGACGCCGGGGTCCCCTCAGATGACACGCTGCGTT
CCTTTGACACGGTCATTGGAGCAGGGACGCCACCGGGCCTGGCTGAGCCGCTCCTGGTCGTGCGGCCCAAGGACTTGGCCCTGCTACGGC
CTAGCAAACGGCAGCCACCCCTGCGAAGACACTCTCCACCTGGCCGTGCCCCTCGACGGCCCCTGCTTGAAGGTGGGGGCTTCTTTGAGG
ATGAAGACACTAGTGAGGGCAGTGAACTGAGCCCGGCCTCCAGTCTCCGATCGCAGCGCCGCTACAGTACTGACAGCTCCTCTTCTACTT
CCTGCTACTCCCCTGAGAGCTCCCGGGGTGCAGCAGGGGGACCCCGGAAGCGGAGGGCCCCCCATGGGGCTGAGGAGGGAACTGCTGTGC
CCCCCAAGCGGCCATATGGGACCCAGCGGACGCCTAGTACCGCCAGCGCTAAAACACATGCCCGTGTGCTGAGCATGGATGGGGCTGGGG
GTGATGTTCTGAGGCCCCCACTGGCTGGCTGCAAGGCAGAGCTGGAGGCCCAGGTTGGGGTGGAGCAGGCTGCTAGTGAGCCTGTTGTGC
TGCCTGCTGAGGCGCGAAGGGGACCCGCTGCCAACCAGCCCGGCTGGCGGGGGGAGCTGCAGGAGGAAGGTGCTGTGGGGGGAGCGGCCG
AGGAGACTGGCAGGCGGGACCGCTCAAGCAGTGTGAGGCGGACCCAGGCCATTCGGAGACGCCACAATGCAGGCAGCAACCCCACCCCTC
CAGCCTCTGTCATGGGCTCGCCGCCCAGCAGCCTGCAGGAAGCTCAGCGGGGCCGGGCTGCCTCCCACTCCCGGGCGCTGACGCTGCCCT
CTGCGCTGCATTTCGCCTCTTCACTGTTGCTCACCCGGGCCGGTGCCAATGTGCATGAGGCCTGCACCTTTGATGACACTTCTGAGGGTG
CTGTGCACTATTTCTACGATGAGAGCGGTGTGCGGCGTTCCTACACCTTTGGCCTGGCTGGAGGCGGCTACGAGAACCCTGTAGGGCAGC
AAGGGGAGCAGACAGCTAATGGAGCCTGGGACCGACACTCGCATTCCTCCAGCTTCCACTCGGCTGATGTCCCTGAGGCTACAGGCGGCC
TGAACCTGCTGCAGCCGAGGCCTGTGGTTCTGCAGGGCATGCAGGTGCGCCGGGTGCCCCTGGAGATCCCGGAGGAGCAGACACTGATGG
AAGAAGCGCCACCCCGGGCCCAGCATAGTTACAAGTACTGGCTTCTCCCTGGCCGCTGGACCTCTGTGCGCTATGAGCGGCTTGCCCTGC
TGGCTCTGCTGGACCGGACGCGGGGAGTGCTGGAGAACATCTTCGGCGTGGGCCTGAGCAGCCTTGTGGCCTTCCTGGGCTACCTGCTGC
TGCTCAAGGGCTTCTTCACTGACATCTGGGTCTTCCAGTTCTGCCTGGTCATCGCCTCCTGCCAGTACTCCTTGCTGAAGGTGGTGAAGG
TGGGTCTGGTTGAAGACTCTCCCTCCACAGCAGGCGATGGGGACGATTCTCCTGTGGTCAGCCTTACTGTGCCCTCCACATCACCACCCT
CCAGCTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCCTCCCCATCTATGAGCAGCGCCCTGGCCATCGTGGGGAGCCCTAATA
GCCCATATGGGGACGTGATTGGCCTCCAGGTGGACTACTGGCTGGGCCACCCCGGGGAGCGGAGGAGGGAAGGCGACAAGAGGGACGCCA
GCTCGAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTGTCCCGCCTGCCCCATAGTGGGGAGGCCCAGCTTTCTGGCACCATGG
CCATGACTGTGGTCACCAAAGAAAAGAACAAGAAAGTTCCCACCATCTTCCTGAGCAAGAAACCCCGAGAAAAGGAGGTGGATTCTAAGA
GCCAGGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAGCAGCAGCAGACTATGCTGAGAGTGTCCATCGATGGGGTCGAGTGGA
GTGACATCAAGTTCTTCCAGCTGGCAGCCCAGTGGCCCACCCATGTCAAGCACTTTCCAGTGGGACTCTTCAGTGGCAGCAAGGCCACCT
GAGGCCCTGTCTCCCAGCCACTTTCCCTCCTGGCACTGCCACCAGCCTCACCGCCTGCGGGCAGGGGGAGGCCAGCAGGCCCGGGCCCAG
CACCCCTTCCCTGGCACCAGGGTCTGCCTCTCACTCGCCCAGGTCCCGAAGGACACTGCCACAGGGACGCCTTCCCTCCCCTCCCCTCCA
GCCCACCCCTGCACAGCCCCTCCTCCTTCCCGCTTTTCCCCTTCTCCCTCCTGCTCCAGGCCCAAGGCGTGTTGGTTTTGCCTTCTGGTG
CCCATAGTCCCCTGGACTGAGTCCCCCAGGCCTTCCTTCACCCGACTTCCAAACTCTTCCTTGTGGTATCAGTTTCCTTCTCGGAAATGA
GAAAGCTGGAATCCTGGTCCCCAGCAGGAGAGCCTAGTCCTCCCCCAGCCCCTCCAGCCACCAGGGTGTCCTCTAGGATGCAGCTGCCAG
ATCCACTCACTCTGCTGCCTCCAGCAGGACCCAAGGCCACTTTCAACTCTTATGGGGTTCTCCACCTGCCCCAGAGCTTCTCAAGGGAGG
GTAAGGGGGCACCCTGAGCCCACAGGACCCCTACTTCACAGCTCACAGGGGCAGGAGGCAGCTCCCCTGCCTCCAGGACCCTGTTGCTAT
GGTGACACAGCGTTTCTAGGACAGAGGGGCCTCCCAGTCTCCCCCCACCACCCGTGCACGACTTCCTCACCACCCCCAGGTTCCCTGCAG
ATGTCGTGTGTGTCCTGAGTGTTTCTTTGGTTCTTTGCACGCCAAGTCTCTTGGTTGTACCATGTGACACACCCTGTGCACTGGTCGCTG
TCTTCGTGGCTTCCACCCTTGTTAATGATGCTCCTGCCTCTGCCTCCCAGCCCCTCACCCAGCACAGCTCTGCCTGGACTTGGAGAGATG
GGAGGCAGACCCCCACCACCATACATGCTGTCTGTGGCCCCTCAGACATTCTGTTTCATCTCCCATTCATCTCCCTCCTCCCACCGTGTC
AGTTTTTCTGCCTTTCCCTGCTCTGTTCTTCCCCCTCCTTAGGCCCCAGCCTGGGCCCAGACCCATCCTCCCAGCCAGGTTTCCCTCCAG
CAGGCTCCTTCCCTCCCTGTCACCTCCCTCTCACCAACCCGGGGTCTGAGCCCCTCATTCCTGACCGTCCGTGTTCTCAGGAGTGGTTGA
GGACACAGGGCCCCAGCCCAGCCCTCTGCACCCCCCAGCCCGGCCATCTGCGCCCCACAGCCCCTTTGGAGCTTTTCTCTTGTCCTCTCA
CTCCTTCCCAGAAGTTTTTGCACAGAACTTCATTTTGAAAGTGTTTTTCTCATTCTCCATACCTCCCCCAAGCTCTCCTCCAGCCCTTCC
CAGGGCTCAGCCCTGCTGTCCTGAGCGTCTCCTGGGCCAGAGAGAGGAGATGGGGGTGGGAGGGACTGAGTTGATGTTGGGTTTTTCATT

>In-frame_ENST00000355703_ENST00000320580_TCGA-LA-A7SW_PCNXL3_chr11_65391115_+_PACS1_chr11_66006275_length(amino acids)=1105AA_start in transcript=374_stop in transcript=3691
MLAPSRGRAPLPRWGRPWREREAGPRGPQAPDGAWAGGRPHEGPGRGGAGSSGGAMGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFH
LYVWIFLLIFPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRSSTMGELEEEPAQGDSNPPRDPGVEMTVFRK
VSSTPPVRCSSQHSVFGFNQVSELLPRMEDSGPLRDIKELVREQGSNNVIVTSADREMLKLSSQEKLIGDLPQTPPGAVPDPSLASTDSS
EPSPLAGDGAPWSGSSMADTPMSPLLKGSLSQELSKSFLTLTQPDRALVRTSSRREQRRGAGGYQPLDRRGSGEPTPQKAGSSDSCFSGT
DRETLSSFKSEKTNSTHLDSPPGGPAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVIGAGTPPGLAEPLLVVRPKDLALLRPSKRQ
PPLRRHSPPGRAPRRPLLEGGGFFEDEDTSEGSELSPASSLRSQRRYSTDSSSSTSCYSPESSRGAAGGPRKRRAPHGAEEGTAVPPKRP
YGTQRTPSTASAKTHARVLSMDGAGGDVLRPPLAGCKAELEAQVGVEQAASEPVVLPAEARRGPAANQPGWRGELQEEGAVGGAAEETGR
RDRSSSVRRTQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAASHSRALTLPSALHFASSLLLTRAGANVHEACTFDDTSEGAVHYF
YDESGVRRSYTFGLAGGGYENPVGQQGEQTANGAWDRHSHSSSFHSADVPEATGGLNLLQPRPVVLQGMQVRRVPLEIPEEQTLMEEAPP
RAQHSYKYWLLPGRWTSVRYERLALLALLDRTRGVLENIFGVGLSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKVVKVGLVE
DSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNT
LKSVFRSVQVSRLPHSGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKF

--------------------------------------------------------------
>In-frame_ENST00000355703_ENST00000529757_TCGA-LA-A7SW_PCNXL3_chr11_65391115_+_PACS1_chr11_66006275_length(transcript)=3694nt_BP=3050nt
GGCGCATGCGCCACTGCAGGCTGGCGGTTCGCGGCTCCTTCTTCCGGCCTCCTCCTTAGGCCGGCACCAGCAGAAGCCGGGCGAGCGCGG
AGCCCCAAGCAAGTGACCTGCGACCCCGAAAGTGGACCCCAGATCCTGGGGTTCTCCCTGGTCCGGAGACTAGGGAGCTGTCGCCTGCAC
CCCGGGAGCACCCACCCCACGACCACCTCTGGATGCCGCCGACGGGTACCCGGCCCGTGCCCCGCGCCTGCCTGCCGGCTCGGCCCCTCG
GAGCAATTCTGGGCCAGGAGTGGGGACCCGGACCCCGCCCCTGATGCAGCCCCACCCCCGCGTCCGGGCCTTGCACCACTGACTGTCCCG
GCCGGCCCCGCCCCCTGCTCGCACCCTCGCGCGGCCGAGCCCCCCTCCCCCGCTGGGGGAGGCCATGGCGTGAGCGTGAGGCCGGGCCCC
GGGGCCCTCAGGCGCCAGACGGGGCATGGGCCGGGGGCCGCCCCCATGAGGGTCCCGGGAGGGGGGGCGCGGGCAGCAGCGGCGGGGCCA
TGGGGTCGCAGGTGTTGCAGATCCTGCGCCAGGGGGTGTGGGCCTCGCTCACCGGCGGTTGGTTCTTCGACCCGCACCAGAGCACCTTCT
CCAACTGCTTCCACCTCTATGTGTGGATCTTCCTGCTCATCTTTCCCTTCTTACTGTACATGGTCCTGCCTCCCAGCTTGATGGTGGCCG
GCGTGTACTGCCTCGTGGTGGCTGTCATCTTTGCTACTATCAAGACTGTCAATTATCGGCTTCATGCCATGTTTGACCAGGGCGAGATCG
TGGAGAAGCGCAGCTCTACCATGGGGGAGCTGGAGGAAGAGCCTGCCCAGGGGGACAGCAATCCACCCAGGGACCCCGGAGTGGAGATGA
CAGTGTTCCGGAAAGTCAGTTCCACACCCCCGGTGCGCTGCAGCTCCCAGCACTCTGTGTTTGGCTTCAACCAGGTCTCGGAGCTGCTGC
CCCGAATGGAGGACTCTGGGCCCCTTAGAGACATCAAGGAGCTGGTGCGGGAGCAGGGCAGCAACAATGTGATCGTGACTTCTGCCGACC
GAGAGATGCTGAAGCTCAGCTCGCAGGAGAAACTGATTGGAGACCTTCCCCAGACGCCTCCAGGGGCTGTCCCAGACCCCTCTCTTGCCA
GTACAGACTCTTCAGAGCCTTCTCCCCTGGCTGGAGATGGAGCGCCCTGGAGTGGGAGCAGCATGGCTGACACTCCCATGAGCCCCCTGC
TGAAGGGGAGCCTCAGCCAGGAGCTGAGCAAGAGCTTCCTGACCCTGACCCAGCCTGACCGGGCCCTGGTGAGGACCAGCAGTCGACGGG
AACAACGCAGGGGGGCAGGTGGCTATCAGCCCCTTGACCGGCGGGGCTCAGGGGAGCCCACGCCCCAGAAAGCCGGCTCCTCAGACTCCT
GCTTCAGCGGCACTGACAGGGAGACATTGAGCAGCTTCAAGAGTGAGAAGACCAACTCCACCCATCTGGACAGCCCCCCAGGGGGGCCAG
CCCCTGAGGGCAGCGACACAGACCCACCCTCTGAGGCTGAGCTGCCTGCCTCACCAGACGCCGGGGTCCCCTCAGATGACACGCTGCGTT
CCTTTGACACGGTCATTGGAGCAGGGACGCCACCGGGCCTGGCTGAGCCGCTCCTGGTCGTGCGGCCCAAGGACTTGGCCCTGCTACGGC
CTAGCAAACGGCAGCCACCCCTGCGAAGACACTCTCCACCTGGCCGTGCCCCTCGACGGCCCCTGCTTGAAGGTGGGGGCTTCTTTGAGG
ATGAAGACACTAGTGAGGGCAGTGAACTGAGCCCGGCCTCCAGTCTCCGATCGCAGCGCCGCTACAGTACTGACAGCTCCTCTTCTACTT
CCTGCTACTCCCCTGAGAGCTCCCGGGGTGCAGCAGGGGGACCCCGGAAGCGGAGGGCCCCCCATGGGGCTGAGGAGGGAACTGCTGTGC
CCCCCAAGCGGCCATATGGGACCCAGCGGACGCCTAGTACCGCCAGCGCTAAAACACATGCCCGTGTGCTGAGCATGGATGGGGCTGGGG
GTGATGTTCTGAGGCCCCCACTGGCTGGCTGCAAGGCAGAGCTGGAGGCCCAGGTTGGGGTGGAGCAGGCTGCTAGTGAGCCTGTTGTGC
TGCCTGCTGAGGCGCGAAGGGGACCCGCTGCCAACCAGCCCGGCTGGCGGGGGGAGCTGCAGGAGGAAGGTGCTGTGGGGGGAGCGGCCG
AGGAGACTGGCAGGCGGGACCGCTCAAGCAGTGTGAGGCGGACCCAGGCCATTCGGAGACGCCACAATGCAGGCAGCAACCCCACCCCTC
CAGCCTCTGTCATGGGCTCGCCGCCCAGCAGCCTGCAGGAAGCTCAGCGGGGCCGGGCTGCCTCCCACTCCCGGGCGCTGACGCTGCCCT
CTGCGCTGCATTTCGCCTCTTCACTGTTGCTCACCCGGGCCGGTGCCAATGTGCATGAGGCCTGCACCTTTGATGACACTTCTGAGGGTG
CTGTGCACTATTTCTACGATGAGAGCGGTGTGCGGCGTTCCTACACCTTTGGCCTGGCTGGAGGCGGCTACGAGAACCCTGTAGGGCAGC
AAGGGGAGCAGACAGCTAATGGAGCCTGGGACCGACACTCGCATTCCTCCAGCTTCCACTCGGCTGATGTCCCTGAGGCTACAGGCGGCC
TGAACCTGCTGCAGCCGAGGCCTGTGGTTCTGCAGGGCATGCAGGTGCGCCGGGTGCCCCTGGAGATCCCGGAGGAGCAGACACTGATGG
AAGAAGCGCCACCCCGGGCCCAGCATAGTTACAAGTACTGGCTTCTCCCTGGCCGCTGGACCTCTGTGCGCTATGAGCGGCTTGCCCTGC
TGGCTCTGCTGGACCGGACGCGGGGAGTGCTGGAGAACATCTTCGGCGTGGGCCTGAGCAGCCTTGTGGCCTTCCTGGGCTACCTGCTGC
TGCTCAAGGGCTTCTTCACTGACATCTGGGTCTTCCAGTTCTGCCTGGTCATCGCCTCCTGCCAGTACTCCTTGCTGAAGGTGGTGAAGG
TGGGTCTGGTTGAAGACTCTCCCTCCACAGCAGGCGATGGGGACGATTCTCCTGTGGTCAGCCTTACTGTGCCCTCCACATCACCACCCT
CCAGCTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCCTCCCCATCTATGAGCAGCGCCCTGGCCATCGTGGGGAGCCCTAATA
GCCCATATGGGGACGTGATTGGCCTCCAGGTGGACTACTGGCTGGGCCACCCCGGGGAGCGGAGGAGGGAAGGCGACAAGAGGGACGCCA
GCTCGAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTGTCCCGCCTGCCCCATAGTGGGGAGGCCCAGCTTTCTGGCACCATGG
CCATGACTGTGGTCACCAAAGAAAAGAACAAGAAAGTTCCCACCATCTTCCTGAGCAAGAAACCCCGAGAAAAGGAGGTGGATTCTAAGA
GCCAGGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAGCAGCAGCAGACTATGCTGAGAGTGTCCATCGATGGGGTCGAGTGGA
GTGACATCAAGTTCTTCCAGCTGGCAGCCCAGTGGCCCACCCATGTCAAGCACTTTCCAGTGGGACTCTTCAGTGGCAGCAAGGCCACCT

>In-frame_ENST00000355703_ENST00000529757_TCGA-LA-A7SW_PCNXL3_chr11_65391115_+_PACS1_chr11_66006275_length(amino acids)=1105AA_start in transcript=374_stop in transcript=3691
MLAPSRGRAPLPRWGRPWREREAGPRGPQAPDGAWAGGRPHEGPGRGGAGSSGGAMGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFH
LYVWIFLLIFPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRSSTMGELEEEPAQGDSNPPRDPGVEMTVFRK
VSSTPPVRCSSQHSVFGFNQVSELLPRMEDSGPLRDIKELVREQGSNNVIVTSADREMLKLSSQEKLIGDLPQTPPGAVPDPSLASTDSS
EPSPLAGDGAPWSGSSMADTPMSPLLKGSLSQELSKSFLTLTQPDRALVRTSSRREQRRGAGGYQPLDRRGSGEPTPQKAGSSDSCFSGT
DRETLSSFKSEKTNSTHLDSPPGGPAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVIGAGTPPGLAEPLLVVRPKDLALLRPSKRQ
PPLRRHSPPGRAPRRPLLEGGGFFEDEDTSEGSELSPASSLRSQRRYSTDSSSSTSCYSPESSRGAAGGPRKRRAPHGAEEGTAVPPKRP
YGTQRTPSTASAKTHARVLSMDGAGGDVLRPPLAGCKAELEAQVGVEQAASEPVVLPAEARRGPAANQPGWRGELQEEGAVGGAAEETGR
RDRSSSVRRTQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAASHSRALTLPSALHFASSLLLTRAGANVHEACTFDDTSEGAVHYF
YDESGVRRSYTFGLAGGGYENPVGQQGEQTANGAWDRHSHSSSFHSADVPEATGGLNLLQPRPVVLQGMQVRRVPLEIPEEQTLMEEAPP
RAQHSYKYWLLPGRWTSVRYERLALLALLDRTRGVLENIFGVGLSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKVVKVGLVE
DSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNT
LKSVFRSVQVSRLPHSGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKF

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Fusion Gene PPI Analysis for PCNXL3-PACS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PCNXL3-PACS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PCNXL3-PACS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePACS1C3714756Intellectual Disability2GENOMICS_ENGLAND
TgenePACS1C0005586Bipolar Disorder1CTD_human
TgenePACS1C0005587Depression, Bipolar1CTD_human
TgenePACS1C0013146Drug abuse1CTD_human
TgenePACS1C0013170Drug habituation1CTD_human
TgenePACS1C0013222Drug Use Disorders1CTD_human
TgenePACS1C0024713Manic Disorder1CTD_human
TgenePACS1C0028754Obesity1CTD_human
TgenePACS1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgenePACS1C0038580Substance Dependence1CTD_human
TgenePACS1C0038586Substance Use Disorders1CTD_human
TgenePACS1C0236969Substance-Related Disorders1CTD_human
TgenePACS1C0338831Manic1CTD_human
TgenePACS1C0740858Substance abuse problem1CTD_human
TgenePACS1C1510472Drug Dependence1CTD_human
TgenePACS1C3554343MENTAL RETARDATION, AUTOSOMAL DOMINANT 171GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgenePACS1C4316881Prescription Drug Abuse1CTD_human