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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ARHGEF11-SHC1 (FusionGDB2 ID:6313) |
Fusion Gene Summary for ARHGEF11-SHC1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ARHGEF11-SHC1 | Fusion gene ID: 6313 | Hgene | Tgene | Gene symbol | ARHGEF11 | SHC1 | Gene ID | 9826 | 6464 |
Gene name | Rho guanine nucleotide exchange factor 11 | SHC adaptor protein 1 | |
Synonyms | GTRAP48|PDZ-RHOGEF | SHC|SHCA | |
Cytomap | 1q23.1 | 1q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | rho guanine nucleotide exchange factor 11Rho guanine exchange factor (GEF) 11Rho guanine nucleotide exchange factor (GEF) 11RhoA-specific guanine nucleotide exchange factorRhoGEF glutamate transport modulatorglutamate transporter EAAT4-associated pro | SHC-transforming protein 1SH2 domain protein C1SHC (Src homology 2 domain containing) transforming protein 1SHC-transforming protein 3SHC-transforming protein A | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | O15085 | . | |
Ensembl transtripts involved in fusion gene | ENST00000368194, ENST00000487682, ENST00000361409, ENST00000315174, | ENST00000368445, ENST00000368449, ENST00000448116, ENST00000368450, ENST00000368453, ENST00000606391, ENST00000490667, | |
Fusion gene scores | * DoF score | 11 X 5 X 7=385 | 11 X 4 X 8=352 |
# samples | 14 | 10 | |
** MAII score | log2(14/385*10)=-1.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/352*10)=-1.81557542886257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARHGEF11 [Title/Abstract] AND SHC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ARHGEF11(157014091)-SHC1(154942675), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ARHGEF11 | GO:0007186 | G protein-coupled receptor signaling pathway | 15755723 |
Hgene | ARHGEF11 | GO:0007266 | Rho protein signal transduction | 10026210 |
Hgene | ARHGEF11 | GO:0045893 | positive regulation of transcription, DNA-templated | 10026210 |
Tgene | SHC1 | GO:0000165 | MAPK cascade | 14676841 |
Tgene | SHC1 | GO:0000187 | activation of MAPK activity | 14676841 |
Tgene | SHC1 | GO:0071363 | cellular response to growth factor stimulus | 20010870 |
Fusion gene breakpoints across ARHGEF11 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across SHC1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-DX-AB2V-01A | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
ChimerDB4 | SARC | TCGA-DX-AB2O-01A | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
ChimerDB4 | SARC | TCGA-DX-AB2V-01A | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
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Fusion Gene ORF analysis for ARHGEF11-SHC1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000368194 | ENST00000368445 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000368194 | ENST00000368449 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000368194 | ENST00000448116 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-5UTR | ENST00000368194 | ENST00000368450 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-5UTR | ENST00000368194 | ENST00000368453 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000368194 | ENST00000606391 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000368194 | ENST00000490667 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-3CDS | ENST00000487682 | ENST00000368445 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000487682 | ENST00000368449 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000487682 | ENST00000448116 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-5UTR | ENST00000487682 | ENST00000368450 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-5UTR | ENST00000487682 | ENST00000368453 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000487682 | ENST00000606391 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000487682 | ENST00000490667 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
In-frame | ENST00000361409 | ENST00000368445 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000361409 | ENST00000368449 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000361409 | ENST00000448116 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-5UTR | ENST00000361409 | ENST00000368450 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-5UTR | ENST00000361409 | ENST00000368453 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000361409 | ENST00000606391 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
5CDS-intron | ENST00000361409 | ENST00000490667 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-3CDS | ENST00000315174 | ENST00000368445 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000315174 | ENST00000368449 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000315174 | ENST00000448116 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-5UTR | ENST00000315174 | ENST00000368450 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-5UTR | ENST00000315174 | ENST00000368453 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000315174 | ENST00000606391 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
intron-intron | ENST00000315174 | ENST00000490667 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000368194 | ARHGEF11 | chr1 | 157014091 | - | ENST00000368445 | SHC1 | chr1 | 154942675 | - | 4002 | 1072 | 3064 | 3624 | 186 |
ENST00000361409 | ARHGEF11 | chr1 | 157014091 | - | ENST00000368445 | SHC1 | chr1 | 154942675 | - | 3705 | 775 | 2767 | 3327 | 186 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000368194 | ENST00000368445 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - | 0.67627233 | 0.32372767 |
ENST00000361409 | ENST00000368445 | ARHGEF11 | chr1 | 157014091 | - | SHC1 | chr1 | 154942675 | - | 0.68281937 | 0.31718066 |
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Fusion Genomic Features for ARHGEF11-SHC1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ARHGEF11-SHC1 |
Go to FGviewer for the breakpoints of chr1:157014091-chr1:154942675 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ARHGEF11 | . |
FUNCTION: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368445 | 0 | 12 | 411_474 | 0 | 584.0 | Compositional bias | Note=Pro-rich | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368450 | 0 | 13 | 411_474 | 0 | 474.0 | Compositional bias | Note=Pro-rich | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368453 | 0 | 13 | 411_474 | 0 | 475.0 | Compositional bias | Note=Pro-rich | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000448116 | 0 | 12 | 411_474 | 0 | 585.0 | Compositional bias | Note=Pro-rich | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368445 | 0 | 12 | 156_339 | 0 | 584.0 | Domain | PID | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368445 | 0 | 12 | 488_579 | 0 | 584.0 | Domain | SH2 | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368450 | 0 | 13 | 156_339 | 0 | 474.0 | Domain | PID | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368450 | 0 | 13 | 488_579 | 0 | 474.0 | Domain | SH2 | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368453 | 0 | 13 | 156_339 | 0 | 475.0 | Domain | PID | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368453 | 0 | 13 | 488_579 | 0 | 475.0 | Domain | SH2 | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000448116 | 0 | 12 | 156_339 | 0 | 585.0 | Domain | PID | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000448116 | 0 | 12 | 488_579 | 0 | 585.0 | Domain | SH2 | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368445 | 0 | 12 | 340_487 | 0 | 584.0 | Region | Note=CH1 | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368450 | 0 | 13 | 340_487 | 0 | 474.0 | Region | Note=CH1 | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000368453 | 0 | 13 | 340_487 | 0 | 475.0 | Region | Note=CH1 | |
Tgene | SHC1 | chr1:157014091 | chr1:154942675 | ENST00000448116 | 0 | 12 | 340_487 | 0 | 585.0 | Region | Note=CH1 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000361409 | - | 1 | 40 | 444_470 | 10.666666666666666 | 1523.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000368194 | - | 1 | 41 | 444_470 | 10.666666666666666 | 1563.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000361409 | - | 1 | 40 | 1094_1099 | 10.666666666666666 | 1523.0 | Compositional bias | Note=Poly-Pro |
Hgene | ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000368194 | - | 1 | 41 | 1094_1099 | 10.666666666666666 | 1563.0 | Compositional bias | Note=Poly-Pro |
Hgene | ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000361409 | - | 1 | 40 | 306_486 | 10.666666666666666 | 1523.0 | Domain | RGSL |
Hgene | ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000361409 | - | 1 | 40 | 47_126 | 10.666666666666666 | 1523.0 | Domain | PDZ |
Hgene | ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000361409 | - | 1 | 40 | 734_923 | 10.666666666666666 | 1523.0 | Domain | DH |
Hgene | ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000361409 | - | 1 | 40 | 965_1079 | 10.666666666666666 | 1523.0 | Domain | PH |
Hgene | ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000368194 | - | 1 | 41 | 306_486 | 10.666666666666666 | 1563.0 | Domain | RGSL |
Hgene | ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000368194 | - | 1 | 41 | 47_126 | 10.666666666666666 | 1563.0 | Domain | PDZ |
Hgene | ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000368194 | - | 1 | 41 | 734_923 | 10.666666666666666 | 1563.0 | Domain | DH |
Hgene | ARHGEF11 | chr1:157014091 | chr1:154942675 | ENST00000368194 | - | 1 | 41 | 965_1079 | 10.666666666666666 | 1563.0 | Domain | PH |
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Fusion Gene Sequence for ARHGEF11-SHC1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000368194_ENST00000368445_TCGA-DX-AB2V-01A_ARHGEF11_chr1_157014091_-_SHC1_chr1_154942675_length(transcript)=4002nt_BP=1072nt AGCGAAATCTCCGTTTCATGGAGGCTGAGGCAAGAGAAAATTTCGGAGCCTGGATGTGGAGGAGCCCAACAGCAGAACTAACTCAGGAAA TTGTCTTTCAGAAAAAGGCCGAACGTAGGCTGGGTCTGAGAATCAGGCTGGGGTAGGTGGAGGAACCTGCAAGTTTAAAGGAAAAAGAAA AGGAGAGAATATTTTCAGAGATTATCTCTGGTTTGTTATCATTACTACCATCTTAAAGGTAAAAAGCATTGCATTTCAGGTGTTCTTTGA TTTTTATTTTATTTTTTTTTTTGGTGCAATTGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTC CATAAATTTTGGTTCCCAGGGTTGCACTGGACTTGGAAGGAGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGT ACAAATCAGCCGAAAGAATTTTTCCAAGTGCCATTTCGGATTTATTAATCCTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCA TATTAAGCATTGGAGACTAGAAAATTACTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCAACAGAAGGACAGCTGAGAAAGCTGGATTTA AAGGATGGTTTTATCTGTACTTTGCAGTTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTTTTTTTTGGCCATAGTGCTAA CCTTGAAGAGATTCGTGGCTGGGTTTTTGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTCTTTTCTTTTC TTTTTTTTTAAAGCGGGGGAGGGGAAGAGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGT CCTGAGAGCTGGAGGAGAAAGGATTCTATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGAT CAAGACACCAAAGCTACAGGATTCTGGAACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTTCGGAC TAAGGATCACCGCTTTGAAAGTGTCAGTCACCTTATCAGCTACCACATGGACAATCACTTGCCCATCATCTCTGCGGGCAGCGAACTGTG TCTACAGCAACCTGTGGAGCGGAAACTGTGATCTGCCCTAGCGCTCTCTTCCAGAAGATGCCCTCCAATCCTTTCCACCCTATTCCCTAA CTCTCGGGACCTCGTTTGGGAGTGTTCTGTGGGCTTGGCCTTGTGTCAGAGCTGGGAGTAGCATGGACTCTGGGTTTCATATCCAGCTGA GTGAGAGGGTTTGAGTCAAAAGCCTGGGTGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGTATTAATGTACAGAGTGGCCCCTC ACCTGGGCCTTTCCTGTGCCAACCTGATGCCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAATGTCCTGTGGTGACAGGCCCAGTG GAACAGTCACCCTTCTGGGCAAGGGGGAACAAATCACACCTCTGGGCTTCAGGGTATCCCAGACCCCTCTCAACACCCGCCCCCCCCATG TTTAAACTTTGTGCCTTTGACCATCTCTTAGGTCTAATGATATTTTATGCAAACAGTTCTTGGACCCCTGAATTCAATGACAGGGATGCC AACACCTTCTTGGCTTCTGGGACCTGTGTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAACAGAGGCAGGAGTGGCAGCTGTCC CCTCTCCCTGGGGATATGCAACCCTTAGAGATTGCCCCAGAGCCCCACTCCCGGCCAGGCGGGAGATGGACCCCTCCCTTGCTCAGTGCC TCCTGGCCGGGGCCCCTCACCCCAAGGGGTCTGTATATACATTTCATAAGGCCTGCCCTCCCATGTTGCATGCCTATGTACTCTACGCCA AAGTGCAGCCCTTCCTCCTGAAGCCTCTGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGACTGAATTTGGGCCTCTTGTACAGT TAACTCTCCCAGGTGGATTTTGTGGAGGTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAATCCCCACATACCATCTGTAGAGTT GGAACTGCATTCTTTTAAAGTTTTATATGCATATATTTTAGGGCTGTAGACTTACTTTCCTATTTTCTTTTCCATTGCTTATTCTTGAGC ACAAAATGATAATCAATTATTACATTTATACATCACCTTTTTGACTTTTCCAAGCCCTTTTACAGCTCTTGGCATTTTCCTCGCCTAGGC CTGTGAGGTAACTGGGATCGCACCTTTTATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCTAGGACTAGAAAAACTTGGGTCTC TTACCGCGAGACTGAGAGGCAGAAGTCAGCCCGAATGCCTGTCAGTTTCATGGAGGGGAAACGCAAAACCTGCAGTTCCTGAGTACCTTC TACAGGCCCGGCCCAGCCTAGGCCCGGGGTGGCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGCCTTGTGGATAAGGGAGAGTTGAC CGTTTTCATCCTGGCCTCCTTTTGCTGTTTGGATGTTTCCACGGGTCTCACTTATACCAAAGGGAAAACTCTTCATTAAAGTCCGTATTT CTTCTAAGCCCTTCGAAGATGCTCTTCGCGTGCCTCCACCTCCCCAGTCGGTGTCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCC ATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTGCTGCAGCTCAATGGGGACTTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGT ATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAGCATTTGCTACTGGTGGACCCTGAGGGTGTGGCAGAGAGCTTTTTGATGATCCCTC CTATGTCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCCAATCCTGCTATCAATGGCAGTGCACCCCG GGACCTGTTTGACATGACCTGTAGGACAGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCAGGAT GGCTGGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAACCCCC CTTGGGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCCAGCCA CTTGGGAGCTACATTGCCTGCCACATTCTGGAGTGTCCCGAAGGGCTTGCCCAGGATGTCATCAGCACCATTGGCCAGGCCTTCGAGTTG CGCTTCAAACAATACCTCAGGAACCCACCCAAACTGGTCACCCCTCATGACAGGACACAGCCGAGTATGTCGCCTATGTTGCCAAAGACC CTGTGAATCAGAGAGATCATCGCCAACCACCACATGCAATCTATCTCATTTGCATCCGGCGGGGATCCGCCCTGTAGCCGCCCGCTCAGC TCTATCCTGGGGAGGAGTAACCTGAAATTTGCTGGAATGCCAATCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCATGGCCGCAGAC TGCAAACAGGGAGGCCATCAGTCTGGTGTGTGAGGCTGTGCCGGGTGCTAAGGGGGCGACAAGGAGGAGAAAGTACATGGGTTGTGTGGA GGTCCTCCAGTCAATGCGTGCCCTGGACTTCAACACCCGGACTCAGGTCACCAGGACATGAACAAGCTGAGTGGAGGCGGCGGGCGCAGG ACTCGGGTGGAAGGGGGCCAGCTTGGGGGCGAGGAGTGGACCCGCCACGGGAGCTTTGTCAATAAGCCCACGCGGGGCTGGCTGCATCCC >In-frame_ENST00000368194_ENST00000368445_TCGA-DX-AB2V-01A_ARHGEF11_chr1_157014091_-_SHC1_chr1_154942675_length(amino acids)=186AA_start in transcript=3064_stop in transcript=3624 MFDMTCRTACWGRSRSPQTDATSTTLSRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHL GATLPATFWSVPKGLPRMSSAPLARPSSCASNNTSGTHPNWSPLMTGHSRVCRLCCQRPCESERSSPTTTCNLSHLHPAGIRPVAARSAL -------------------------------------------------------------- >In-frame_ENST00000361409_ENST00000368445_TCGA-DX-AB2V-01A_ARHGEF11_chr1_157014091_-_SHC1_chr1_154942675_length(transcript)=3705nt_BP=775nt AATTGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTCCATAAATTTTGGTTCCCAGGGTTGCAC TGGACTTGGAAGGAGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGTACAAATCAGCCGAAAGAATTTTTCCAA GTGCCATTTCGGATTTATTAATCCTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCATATTAAGCATTGGAGACTAGAAAATTA CTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCAACAGAAGGACAGCTGAGAAAGCTGGATTTAAAGGATGGTTTTATCTGTACTTTGCAG TTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTTTTTTTTGGCCATAGTGCTAACCTTGAAGAGATTCGTGGCTGGGTTTT TGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTCTTTTCTTTTCTTTTTTTTTAAAGCGGGGGAGGGGAAG AGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGTCCTGAGAGCTGGAGGAGAAAGGATTCT ATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGATCAAGACACCAAAGCTACAGGATTCTGG AACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTTCGGACTAAGGATCACCGCTTTGAAAGTGTCAG TCACCTTATCAGCTACCACATGGACAATCACTTGCCCATCATCTCTGCGGGCAGCGAACTGTGTCTACAGCAACCTGTGGAGCGGAAACT GTGATCTGCCCTAGCGCTCTCTTCCAGAAGATGCCCTCCAATCCTTTCCACCCTATTCCCTAACTCTCGGGACCTCGTTTGGGAGTGTTC TGTGGGCTTGGCCTTGTGTCAGAGCTGGGAGTAGCATGGACTCTGGGTTTCATATCCAGCTGAGTGAGAGGGTTTGAGTCAAAAGCCTGG GTGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGTATTAATGTACAGAGTGGCCCCTCACCTGGGCCTTTCCTGTGCCAACCTGA TGCCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAATGTCCTGTGGTGACAGGCCCAGTGGAACAGTCACCCTTCTGGGCAAGGGGG AACAAATCACACCTCTGGGCTTCAGGGTATCCCAGACCCCTCTCAACACCCGCCCCCCCCATGTTTAAACTTTGTGCCTTTGACCATCTC TTAGGTCTAATGATATTTTATGCAAACAGTTCTTGGACCCCTGAATTCAATGACAGGGATGCCAACACCTTCTTGGCTTCTGGGACCTGT GTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAACAGAGGCAGGAGTGGCAGCTGTCCCCTCTCCCTGGGGATATGCAACCCTTA GAGATTGCCCCAGAGCCCCACTCCCGGCCAGGCGGGAGATGGACCCCTCCCTTGCTCAGTGCCTCCTGGCCGGGGCCCCTCACCCCAAGG GGTCTGTATATACATTTCATAAGGCCTGCCCTCCCATGTTGCATGCCTATGTACTCTACGCCAAAGTGCAGCCCTTCCTCCTGAAGCCTC TGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGACTGAATTTGGGCCTCTTGTACAGTTAACTCTCCCAGGTGGATTTTGTGGAG GTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAATCCCCACATACCATCTGTAGAGTTGGAACTGCATTCTTTTAAAGTTTTATA TGCATATATTTTAGGGCTGTAGACTTACTTTCCTATTTTCTTTTCCATTGCTTATTCTTGAGCACAAAATGATAATCAATTATTACATTT ATACATCACCTTTTTGACTTTTCCAAGCCCTTTTACAGCTCTTGGCATTTTCCTCGCCTAGGCCTGTGAGGTAACTGGGATCGCACCTTT TATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCTAGGACTAGAAAAACTTGGGTCTCTTACCGCGAGACTGAGAGGCAGAAGTC AGCCCGAATGCCTGTCAGTTTCATGGAGGGGAAACGCAAAACCTGCAGTTCCTGAGTACCTTCTACAGGCCCGGCCCAGCCTAGGCCCGG GGTGGCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGCCTTGTGGATAAGGGAGAGTTGACCGTTTTCATCCTGGCCTCCTTTTGCTG TTTGGATGTTTCCACGGGTCTCACTTATACCAAAGGGAAAACTCTTCATTAAAGTCCGTATTTCTTCTAAGCCCTTCGAAGATGCTCTTC GCGTGCCTCCACCTCCCCAGTCGGTGTCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTG AGGCACTGCTGCAGCTCAATGGGGACTTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGC AGCCTAAGCATTTGCTACTGGTGGACCCTGAGGGTGTGGCAGAGAGCTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAGACAA GGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCCAATCCTGCTATCAATGGCAGTGCACCCCGGGACCTGTTTGACATGACCTGTAGGAC AGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCAGGATGGCTGGCTTTGATGGCTCAGCATGGGA TGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAACCCCCCTTGGGGGGGGTGGTAGACATGAGGCT TCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCCAGCCACTTGGGAGCTACATTGCCTGCCACATT CTGGAGTGTCCCGAAGGGCTTGCCCAGGATGTCATCAGCACCATTGGCCAGGCCTTCGAGTTGCGCTTCAAACAATACCTCAGGAACCCA CCCAAACTGGTCACCCCTCATGACAGGACACAGCCGAGTATGTCGCCTATGTTGCCAAAGACCCTGTGAATCAGAGAGATCATCGCCAAC CACCACATGCAATCTATCTCATTTGCATCCGGCGGGGATCCGCCCTGTAGCCGCCCGCTCAGCTCTATCCTGGGGAGGAGTAACCTGAAA TTTGCTGGAATGCCAATCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCATGGCCGCAGACTGCAAACAGGGAGGCCATCAGTCTGGT GTGTGAGGCTGTGCCGGGTGCTAAGGGGGCGACAAGGAGGAGAAAGTACATGGGTTGTGTGGAGGTCCTCCAGTCAATGCGTGCCCTGGA CTTCAACACCCGGACTCAGGTCACCAGGACATGAACAAGCTGAGTGGAGGCGGCGGGCGCAGGACTCGGGTGGAAGGGGGCCAGCTTGGG GGCGAGGAGTGGACCCGCCACGGGAGCTTTGTCAATAAGCCCACGCGGGGCTGGCTGCATCCCAACGACAAAGTCATGGGACCCGGGGTT >In-frame_ENST00000361409_ENST00000368445_TCGA-DX-AB2V-01A_ARHGEF11_chr1_157014091_-_SHC1_chr1_154942675_length(amino acids)=186AA_start in transcript=2767_stop in transcript=3327 MFDMTCRTACWGRSRSPQTDATSTTLSRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHL GATLPATFWSVPKGLPRMSSAPLARPSSCASNNTSGTHPNWSPLMTGHSRVCRLCCQRPCESERSSPTTTCNLSHLHPAGIRPVAARSAL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ARHGEF11-SHC1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARHGEF11-SHC1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARHGEF11-SHC1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ARHGEF11 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | SHC1 | C0018800 | Cardiomegaly | 1 | CTD_human |
Tgene | SHC1 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
Tgene | SHC1 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
Tgene | SHC1 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
Tgene | SHC1 | C1383860 | Cardiac Hypertrophy | 1 | CTD_human |
Tgene | SHC1 | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
Tgene | SHC1 | C1862941 | Amyotrophic Lateral Sclerosis, Sporadic | 1 | CTD_human |
Tgene | SHC1 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
Tgene | SHC1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | SHC1 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
Tgene | SHC1 | C4551993 | Amyotrophic Lateral Sclerosis, Familial | 1 | CTD_human |