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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDDC1-ALOX5AP (FusionGDB2 ID:63229)

Fusion Gene Summary for PDDC1-ALOX5AP

check button Fusion gene summary
Fusion gene informationFusion gene name: PDDC1-ALOX5AP
Fusion gene ID: 63229
HgeneTgene
Gene symbol

PDDC1

ALOX5AP

Gene ID

347862

241

Gene nameglutamine amidotransferase like class 1 domain containing 1arachidonate 5-lipoxygenase activating protein
SynonymsPDDC1FLAP
Cytomap

11p15.5

13q12.3

Type of geneprotein-codingprotein-coding
Descriptionglutamine amidotransferase-like class 1 domain-containing protein 1Parkinson disease 7 domain containing 1parkinson disease 7 domain-containing protein 1arachidonate 5-lipoxygenase-activating proteinMK-886-binding protein
Modification date2020031320200313
UniProtAcc.

P20292

Ensembl transtripts involved in fusion geneENST00000397472, ENST00000319863, 
ENST00000526325, ENST00000442059, 
ENST00000524550, ENST00000529966, 
ENST00000380490, ENST00000479597, 
Fusion gene scores* DoF score4 X 7 X 4=1124 X 4 X 3=48
# samples 44
** MAII scorelog2(4/112*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDDC1 [Title/Abstract] AND ALOX5AP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDDC1(767294)-ALOX5AP(31326189), # samples:2
PDDC1(770993)-ALOX5AP(31326189), # samples:2
Anticipated loss of major functional domain due to fusion event.PDDC1-ALOX5AP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneALOX5AP

GO:0019370

leukotriene biosynthetic process

2300173

TgeneALOX5AP

GO:0071277

cellular response to calcium ion

2300173


check buttonFusion gene breakpoints across PDDC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ALOX5AP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FS-A1Z4-06APDDC1chr11

767294

-ALOX5APchr13

31326189

+
ChimerDB4SKCMTCGA-FS-A1Z4-06APDDC1chr11

767294

-ALOX5APchr13

31326189

+
ChimerDB4SKCMTCGA-FS-A1Z4-06APDDC1chr11

770993

-ALOX5APchr13

31326189

+
ChimerDB4SKCMTCGA-FS-A1Z4-06APDDC1chr11

767188

-ALOX5APchr13

31326189

+
ChimerDB4SKCMTCGA-FS-A1Z4-06APDDC1chr11

772427

-ALOX5APchr13

31326189

+
ChimerDB4SKCMTCGA-FS-A1Z4-06APDDC1chr11

770993

-ALOX5APchr13

31326189

+


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Fusion Gene ORF analysis for PDDC1-ALOX5AP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000397472ENST00000380490PDDC1chr11

767294

-ALOX5APchr13

31326189

+
intron-intronENST00000397472ENST00000479597PDDC1chr11

767294

-ALOX5APchr13

31326189

+
intron-3CDSENST00000319863ENST00000380490PDDC1chr11

767294

-ALOX5APchr13

31326189

+
intron-intronENST00000319863ENST00000479597PDDC1chr11

767294

-ALOX5APchr13

31326189

+
intron-3CDSENST00000526325ENST00000380490PDDC1chr11

767294

-ALOX5APchr13

31326189

+
intron-intronENST00000526325ENST00000479597PDDC1chr11

767294

-ALOX5APchr13

31326189

+
intron-3CDSENST00000442059ENST00000380490PDDC1chr11

767294

-ALOX5APchr13

31326189

+
intron-intronENST00000442059ENST00000479597PDDC1chr11

767294

-ALOX5APchr13

31326189

+
intron-3CDSENST00000524550ENST00000380490PDDC1chr11

767294

-ALOX5APchr13

31326189

+
intron-intronENST00000524550ENST00000479597PDDC1chr11

767294

-ALOX5APchr13

31326189

+
intron-3CDSENST00000529966ENST00000380490PDDC1chr11

767294

-ALOX5APchr13

31326189

+
intron-intronENST00000529966ENST00000479597PDDC1chr11

767294

-ALOX5APchr13

31326189

+
intron-3CDSENST00000397472ENST00000380490PDDC1chr11

770993

-ALOX5APchr13

31326189

+
intron-intronENST00000397472ENST00000479597PDDC1chr11

770993

-ALOX5APchr13

31326189

+
In-frameENST00000319863ENST00000380490PDDC1chr11

770993

-ALOX5APchr13

31326189

+
5CDS-intronENST00000319863ENST00000479597PDDC1chr11

770993

-ALOX5APchr13

31326189

+
intron-3CDSENST00000526325ENST00000380490PDDC1chr11

770993

-ALOX5APchr13

31326189

+
intron-intronENST00000526325ENST00000479597PDDC1chr11

770993

-ALOX5APchr13

31326189

+
In-frameENST00000442059ENST00000380490PDDC1chr11

770993

-ALOX5APchr13

31326189

+
5CDS-intronENST00000442059ENST00000479597PDDC1chr11

770993

-ALOX5APchr13

31326189

+
In-frameENST00000524550ENST00000380490PDDC1chr11

770993

-ALOX5APchr13

31326189

+
5CDS-intronENST00000524550ENST00000479597PDDC1chr11

770993

-ALOX5APchr13

31326189

+
5UTR-3CDSENST00000529966ENST00000380490PDDC1chr11

770993

-ALOX5APchr13

31326189

+
5UTR-intronENST00000529966ENST00000479597PDDC1chr11

770993

-ALOX5APchr13

31326189

+
intron-3CDSENST00000397472ENST00000380490PDDC1chr11

767188

-ALOX5APchr13

31326189

+
intron-intronENST00000397472ENST00000479597PDDC1chr11

767188

-ALOX5APchr13

31326189

+
intron-3CDSENST00000319863ENST00000380490PDDC1chr11

767188

-ALOX5APchr13

31326189

+
intron-intronENST00000319863ENST00000479597PDDC1chr11

767188

-ALOX5APchr13

31326189

+
intron-3CDSENST00000526325ENST00000380490PDDC1chr11

767188

-ALOX5APchr13

31326189

+
intron-intronENST00000526325ENST00000479597PDDC1chr11

767188

-ALOX5APchr13

31326189

+
intron-3CDSENST00000442059ENST00000380490PDDC1chr11

767188

-ALOX5APchr13

31326189

+
intron-intronENST00000442059ENST00000479597PDDC1chr11

767188

-ALOX5APchr13

31326189

+
intron-3CDSENST00000524550ENST00000380490PDDC1chr11

767188

-ALOX5APchr13

31326189

+
intron-intronENST00000524550ENST00000479597PDDC1chr11

767188

-ALOX5APchr13

31326189

+
intron-3CDSENST00000529966ENST00000380490PDDC1chr11

767188

-ALOX5APchr13

31326189

+
intron-intronENST00000529966ENST00000479597PDDC1chr11

767188

-ALOX5APchr13

31326189

+
Frame-shiftENST00000397472ENST00000380490PDDC1chr11

772427

-ALOX5APchr13

31326189

+
5CDS-intronENST00000397472ENST00000479597PDDC1chr11

772427

-ALOX5APchr13

31326189

+
Frame-shiftENST00000319863ENST00000380490PDDC1chr11

772427

-ALOX5APchr13

31326189

+
5CDS-intronENST00000319863ENST00000479597PDDC1chr11

772427

-ALOX5APchr13

31326189

+
Frame-shiftENST00000526325ENST00000380490PDDC1chr11

772427

-ALOX5APchr13

31326189

+
5CDS-intronENST00000526325ENST00000479597PDDC1chr11

772427

-ALOX5APchr13

31326189

+
Frame-shiftENST00000442059ENST00000380490PDDC1chr11

772427

-ALOX5APchr13

31326189

+
5CDS-intronENST00000442059ENST00000479597PDDC1chr11

772427

-ALOX5APchr13

31326189

+
Frame-shiftENST00000524550ENST00000380490PDDC1chr11

772427

-ALOX5APchr13

31326189

+
5CDS-intronENST00000524550ENST00000479597PDDC1chr11

772427

-ALOX5APchr13

31326189

+
5UTR-3CDSENST00000529966ENST00000380490PDDC1chr11

772427

-ALOX5APchr13

31326189

+
5UTR-intronENST00000529966ENST00000479597PDDC1chr11

772427

-ALOX5APchr13

31326189

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000319863PDDC1chr11770993-ENST00000380490ALOX5APchr1331326189+130767822993323
ENST00000442059PDDC1chr11770993-ENST00000380490ALOX5APchr1331326189+123360498919273
ENST00000524550PDDC1chr11770993-ENST00000380490ALOX5APchr1331326189+119056113876287

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000319863ENST00000380490PDDC1chr11770993-ALOX5APchr1331326189+0.0058596330.9941403
ENST00000442059ENST00000380490PDDC1chr11770993-ALOX5APchr1331326189+0.0072184590.9927816
ENST00000524550ENST00000380490PDDC1chr11770993-ALOX5APchr1331326189+0.0041214080.9958786

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Fusion Genomic Features for PDDC1-ALOX5AP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PDDC1chr11770992-ALOX5APchr1331326188+5.41E-060.99999464
PDDC1chr11772426-ALOX5APchr1331326188+4.65E-060.99999535
PDDC1chr11770992-ALOX5APchr1331326188+5.41E-060.99999464
PDDC1chr11772426-ALOX5APchr1331326188+4.65E-060.99999535

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDDC1-ALOX5AP


check button Go to

FGviewer for the breakpoints of chr11:770993-chr13:31326189

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ALOX5AP

P20292

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {ECO:0000269|PubMed:2300173, ECO:0000269|PubMed:8440384}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneALOX5APchr11:770993chr13:31326189ENST0000038049015108_11556.666666666666664162.0Intramembrane.
TgeneALOX5APchr11:770993chr13:31326189ENST0000038049015112_12356.666666666666664162.0RegionNote=Inhibitor binding
TgeneALOX5APchr11:770993chr13:31326189ENST0000038049015103_10756.666666666666664162.0Topological domainCytoplasmic
TgeneALOX5APchr11:770993chr13:31326189ENST0000038049015129_16156.666666666666664162.0Topological domainLumenal
TgeneALOX5APchr11:770993chr13:31326189ENST000003804901578_8056.666666666666664162.0Topological domainLumenal
TgeneALOX5APchr11:770993chr13:31326189ENST0000038049015116_12856.666666666666664162.0TransmembraneNote=Helical
TgeneALOX5APchr11:770993chr13:31326189ENST000003804901581_10256.666666666666664162.0TransmembraneNote=Helical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneALOX5APchr11:770993chr13:31326189ENST000003804901520_2756.666666666666664162.0RegionNote=Inhibitor binding
TgeneALOX5APchr11:770993chr13:31326189ENST00000380490151_856.666666666666664162.0Topological domainLumenal
TgeneALOX5APchr11:770993chr13:31326189ENST000003804901531_5256.666666666666664162.0Topological domainCytoplasmic
TgeneALOX5APchr11:770993chr13:31326189ENST000003804901553_7756.666666666666664162.0TransmembraneNote=Helical
TgeneALOX5APchr11:770993chr13:31326189ENST00000380490159_3056.666666666666664162.0TransmembraneNote=Helical


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Fusion Gene Sequence for PDDC1-ALOX5AP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000319863_ENST00000380490_TCGA-FS-A1Z4-06A_PDDC1_chr11_770993_-_ALOX5AP_chr13_31326189_length(transcript)=1307nt_BP=678nt
GACCCAGCGCCGAGCCCGAGCCATGGCGTCCGAGCGGCTCCCTAACAGGCCCGCCTGTCTGCTCGTGGCCAGCGGCGCCGCCGAAGGTGT
GTCGGCCCAGTCCTTCCTCCACTGTTTCACGATGGCCAGCACCGCCTTCAACCTGCAGGTGGCCACCCCTGGGGGGAAAGCCATGGAATT
TGTGGATGTGACTGAGAGCAATGCACGCTGGGTGCAAGACTTCCGCCTCAAGGCTTACGCCAGCCCCGCCAAGCTCGAGTCCATCGATGG
TGCCCGGTACCATGCCCTCCTGATCCCCAGCTGTCCTGGGGCCCTGACCGACCTGGCCAGCAGTGGCTCCCTGGCCCGTATCCTGCAGCA
CTTCCACTCTGAGAGCAAACCCATCTGCGCCGTCGGCCACGGTGTCGCCGCCCTGTGCTGTGCCACCAACGAGGACAGATCCTGGGTGTT
CGACAGCTACAGCCTGACAGGGCCCTCTGTGTGTGAGCTCGTCAGGGCCCCCGGCTTCGCCCGCCTGCCGCTCGTGGTGGAGGACTTCGT
GAAGGATTCGGGCGCCTGCTTCAGTGCAAGCGAGCCTGACGCTGTCCACGTCGTGCTGGACCGCCACCTGGTCACAGGCCAGAATGCCAG
CTCCACTGTCCCGGCCGTGCAGAACCTGCTCTTCCTCTGTGGCAGCCGCCAGAACTGTGTAGATGCGTACCCCACTTTCCTCGCTGTGCT
CTGGTCTGCGGGGCTACTTTGCAGCCAAGTTCCTGCTGCGTTTGCTGGACTGATGTACTTGTTTGTGAGGCAAAAGTACTTTGTCGGTTA
CCTAGGAGAGAGAACGCAGAGCACCCCTGGCTACATATTTGGGAAACGCATCATACTCTTCCTGTTCCTCATGTCCGTTGCTGGCATATT
CAACTATTACCTCATCTTCTTTTTCGGAAGTGACTTTGAAAACTACATAAAGACGATCTCCACCACCATCTCCCCTCTACTTCTCATTCC
CTAACTCTCTGCTGAATATGGGGTTGGTGTTCTCATCTAATCAATACCTACAAGTCATCATAATTCAGCTCTTGAGAGCATTCTGCTCTT
CTTTAGATGGCTGTAAATCTATTGGCCATCTGGGCTTCACAGCTTGAGTTAACCTTGCTTTTCCGGGAACAAAATGATGTCATGTCAGCT
CCGCCCCTTGAACATGACCGTGGCCCCAAATTTGCTATTCCCATGCATTTTGTTTGTTTCTTCACTTATCCTGTTCTCTGAAGATGTTTT

>In-frame_ENST00000319863_ENST00000380490_TCGA-FS-A1Z4-06A_PDDC1_chr11_770993_-_ALOX5AP_chr13_31326189_length(amino acids)=323AA_start in transcript=22_stop in transcript=993
MASERLPNRPACLLVASGAAEGVSAQSFLHCFTMASTAFNLQVATPGGKAMEFVDVTESNARWVQDFRLKAYASPAKLESIDGARYHALL
IPSCPGALTDLASSGSLARILQHFHSESKPICAVGHGVAALCCATNEDRSWVFDSYSLTGPSVCELVRAPGFARLPLVVEDFVKDSGACF
SASEPDAVHVVLDRHLVTGQNASSTVPAVQNLLFLCGSRQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQS

--------------------------------------------------------------
>In-frame_ENST00000442059_ENST00000380490_TCGA-FS-A1Z4-06A_PDDC1_chr11_770993_-_ALOX5AP_chr13_31326189_length(transcript)=1233nt_BP=604nt
GCAGACCCAGCGCCGAGCCCGAGCCATGGCGTCCGAGCGGCTCCCTAACAGGCCCGCCTGTCTGCTCGTGGCCAGCGGCGCCGCCGAAGG
GGAAAGCCATGGAATTTGTGGATGTGACTGAGAGCAATGCACGCTGGGTGCAAGACTTCCGCCTCAAGGCTTACGCCAGCCCCGCCAAGC
TCGAGTCCATCGATGGTGCCCGGTACCATGCCCTCCTGATCCCCAGCTGTCCTGGGGCCCTGACCGACCTGGCCAGCAGTGGCTCCCTGG
CCCGTATCCTGCAGCACTTCCACTCTGAGAGCAAACCCATCTGCGCCGTCGGCCACGGTGTCGCCGCCCTGTGCTGTGCCACCAACGAGG
ACAGATCCTGGGTGTTCGACAGCTACAGCCTGACAGGGCCCTCTGTGTGTGAGCTCGTCAGGGCCCCCGGCTTCGCCCGCCTGCCGCTCG
TGGTGGAGGACTTCGTGAAGGATTCGGGCGCCTGCTTCAGTGCAAGCGAGCCTGACGCTGTCCACGTCGTGCTGGACCGCCACCTGGTCA
CAGGCCAGAATGCCAGCTCCACTGTCCCGGCCGTGCAGAACCTGCTCTTCCTCTGTGGCAGCCGCCAGAACTGTGTAGATGCGTACCCCA
CTTTCCTCGCTGTGCTCTGGTCTGCGGGGCTACTTTGCAGCCAAGTTCCTGCTGCGTTTGCTGGACTGATGTACTTGTTTGTGAGGCAAA
AGTACTTTGTCGGTTACCTAGGAGAGAGAACGCAGAGCACCCCTGGCTACATATTTGGGAAACGCATCATACTCTTCCTGTTCCTCATGT
CCGTTGCTGGCATATTCAACTATTACCTCATCTTCTTTTTCGGAAGTGACTTTGAAAACTACATAAAGACGATCTCCACCACCATCTCCC
CTCTACTTCTCATTCCCTAACTCTCTGCTGAATATGGGGTTGGTGTTCTCATCTAATCAATACCTACAAGTCATCATAATTCAGCTCTTG
AGAGCATTCTGCTCTTCTTTAGATGGCTGTAAATCTATTGGCCATCTGGGCTTCACAGCTTGAGTTAACCTTGCTTTTCCGGGAACAAAA
TGATGTCATGTCAGCTCCGCCCCTTGAACATGACCGTGGCCCCAAATTTGCTATTCCCATGCATTTTGTTTGTTTCTTCACTTATCCTGT

>In-frame_ENST00000442059_ENST00000380490_TCGA-FS-A1Z4-06A_PDDC1_chr11_770993_-_ALOX5AP_chr13_31326189_length(amino acids)=273AA_start in transcript=98_stop in transcript=919
MEFVDVTESNARWVQDFRLKAYASPAKLESIDGARYHALLIPSCPGALTDLASSGSLARILQHFHSESKPICAVGHGVAALCCATNEDRS
WVFDSYSLTGPSVCELVRAPGFARLPLVVEDFVKDSGACFSASEPDAVHVVLDRHLVTGQNASSTVPAVQNLLFLCGSRQNCVDAYPTFL
AVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLL

--------------------------------------------------------------
>In-frame_ENST00000524550_ENST00000380490_TCGA-FS-A1Z4-06A_PDDC1_chr11_770993_-_ALOX5AP_chr13_31326189_length(transcript)=1190nt_BP=561nt
CCGAGCCCGAGCCATGGCGTCCGAGCGGCTCCCTAACAGGCCCGCCTGTCTGCTCGTGGCCAGCGGCGCCGCCGAAGGTGTGTCGGCCCA
GTCCTTCCTCCACTGTTTCACGATGGCCAGCACCGCCTTCAACCTGCAGGTGGCCACCCCTGGGGGGAAAGCCATGGAATTTGTGGATGT
GACTGAGAGCAATGCACGCTGGGTGCAAGACTTCCGCCTCAAGGCTTACGCCAGCCCCGCCAAGCTCGAGTCCATCGATGAACCCATCTG
CGCCGTCGGCCACGGTGTCGCCGCCCTGTGCTGTGCCACCAACGAGGACAGATCCTGGGTGTTCGACAGCTACAGCCTGACAGGGCCCTC
TGTGTGTGAGCTCGTCAGGGCCCCCGGCTTCGCCCGCCTGCCGCTCGTGGTGGAGGACTTCGTGAAGGATTCGGGCGCCTGCTTCAGTGC
AAGCGAGCCTGACGCTGTCCACGTCGTGCTGGACCGCCACCTGGTCACAGGCCAGAATGCCAGCTCCACTGTCCCGGCCGTGCAGAACCT
GCTCTTCCTCTGTGGCAGCCGCCAGAACTGTGTAGATGCGTACCCCACTTTCCTCGCTGTGCTCTGGTCTGCGGGGCTACTTTGCAGCCA
AGTTCCTGCTGCGTTTGCTGGACTGATGTACTTGTTTGTGAGGCAAAAGTACTTTGTCGGTTACCTAGGAGAGAGAACGCAGAGCACCCC
TGGCTACATATTTGGGAAACGCATCATACTCTTCCTGTTCCTCATGTCCGTTGCTGGCATATTCAACTATTACCTCATCTTCTTTTTCGG
AAGTGACTTTGAAAACTACATAAAGACGATCTCCACCACCATCTCCCCTCTACTTCTCATTCCCTAACTCTCTGCTGAATATGGGGTTGG
TGTTCTCATCTAATCAATACCTACAAGTCATCATAATTCAGCTCTTGAGAGCATTCTGCTCTTCTTTAGATGGCTGTAAATCTATTGGCC
ATCTGGGCTTCACAGCTTGAGTTAACCTTGCTTTTCCGGGAACAAAATGATGTCATGTCAGCTCCGCCCCTTGAACATGACCGTGGCCCC
AAATTTGCTATTCCCATGCATTTTGTTTGTTTCTTCACTTATCCTGTTCTCTGAAGATGTTTTGTGACCAGGTTTGTGTTTTCTTAAAAT

>In-frame_ENST00000524550_ENST00000380490_TCGA-FS-A1Z4-06A_PDDC1_chr11_770993_-_ALOX5AP_chr13_31326189_length(amino acids)=287AA_start in transcript=13_stop in transcript=876
MASERLPNRPACLLVASGAAEGVSAQSFLHCFTMASTAFNLQVATPGGKAMEFVDVTESNARWVQDFRLKAYASPAKLESIDEPICAVGH
GVAALCCATNEDRSWVFDSYSLTGPSVCELVRAPGFARLPLVVEDFVKDSGACFSASEPDAVHVVLDRHLVTGQNASSTVPAVQNLLFLC
GSRQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PDDC1-ALOX5AP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDDC1-ALOX5AP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDDC1-ALOX5AP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneALOX5APC0004153Atherosclerosis1CTD_human
TgeneALOX5APC0023895Liver diseases1CTD_human
TgeneALOX5APC0033687Proteinuria1CTD_human
TgeneALOX5APC0086565Liver Dysfunction1CTD_human
TgeneALOX5APC0149504Encephalopathy, Toxic1CTD_human
TgeneALOX5APC0154659Toxic Encephalitis1CTD_human
TgeneALOX5APC0235032Neurotoxicity Syndromes1CTD_human
TgeneALOX5APC1563937Atherogenesis1CTD_human