FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PDE10A-PSMB1 (FusionGDB2 ID:63237)

Fusion Gene Summary for PDE10A-PSMB1

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE10A-PSMB1
Fusion gene ID: 63237
HgeneTgene
Gene symbol

PDE10A

PSMB1

Gene ID

10846

5689

Gene namephosphodiesterase 10Aproteasome 20S subunit beta 1
SynonymsADSD2|HSPDE10A|IOLOD|LINC00473|PDE10A19HC5|PMSB1|PSC5
Cytomap

6q27

6q27

Type of geneprotein-codingprotein-coding
DescriptioncAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3',5' cAMP/cGMP phosphodiesterasedJ416F21.1 (phosphodiesterase 10A)phosphodiesterase 10A1 (PDE10A1)phosphodiesterase 10A7 (PDE10A7)proteasome subunit beta type-1macropain subunit C5multicatalytic endopeptidase complex subunit C5proteasome (prosome, macropain) subunit, beta type, 1proteasome beta 1 subunitproteasome component C5proteasome gamma chainproteasome subunit HC5prote
Modification date2020032020200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000366882, ENST00000354448, 
ENST00000539869, ENST00000535229, 
ENST00000262193, ENST00000462957, 
Fusion gene scores* DoF score8 X 9 X 6=43226 X 7 X 9=1638
# samples 1026
** MAII scorelog2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/1638*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDE10A [Title/Abstract] AND PSMB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDE10A(165956928)-PSMB1(170846428), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PDE10A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PSMB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1LEPDE10Achr6

165956927

-PSMB1chr6

170846428

-
ChimerDB4BRCATCGA-E2-A1LE-01APDE10Achr6

165956928

-PSMB1chr6

170846428

-
ChimerDB4BRCATCGA-E2-A1LE-01APDE10Achr6

165956928

-PSMB1chr6

170846428

-


Top

Fusion Gene ORF analysis for PDE10A-PSMB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000366882ENST00000262193PDE10Achr6

165956927

-PSMB1chr6

170846428

-
5CDS-5UTRENST00000366882ENST00000462957PDE10Achr6

165956927

-PSMB1chr6

170846428

-
In-frameENST00000354448ENST00000262193PDE10Achr6

165956927

-PSMB1chr6

170846428

-
5CDS-5UTRENST00000354448ENST00000462957PDE10Achr6

165956927

-PSMB1chr6

170846428

-
In-frameENST00000539869ENST00000262193PDE10Achr6

165956927

-PSMB1chr6

170846428

-
5CDS-5UTRENST00000539869ENST00000462957PDE10Achr6

165956927

-PSMB1chr6

170846428

-
intron-3CDSENST00000535229ENST00000262193PDE10Achr6

165956927

-PSMB1chr6

170846428

-
intron-5UTRENST00000535229ENST00000462957PDE10Achr6

165956927

-PSMB1chr6

170846428

-
In-frameENST00000366882ENST00000262193PDE10Achr6

165956928

-PSMB1chr6

170846428

-
5CDS-5UTRENST00000366882ENST00000462957PDE10Achr6

165956928

-PSMB1chr6

170846428

-
In-frameENST00000354448ENST00000262193PDE10Achr6

165956928

-PSMB1chr6

170846428

-
5CDS-5UTRENST00000354448ENST00000462957PDE10Achr6

165956928

-PSMB1chr6

170846428

-
In-frameENST00000539869ENST00000262193PDE10Achr6

165956928

-PSMB1chr6

170846428

-
5CDS-5UTRENST00000539869ENST00000462957PDE10Achr6

165956928

-PSMB1chr6

170846428

-
intron-3CDSENST00000535229ENST00000262193PDE10Achr6

165956928

-PSMB1chr6

170846428

-
intron-5UTRENST00000535229ENST00000462957PDE10Achr6

165956928

-PSMB1chr6

170846428

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366882PDE10Achr6165956927-ENST00000262193PSMB1chr6170846428-717321116613165
ENST00000354448PDE10Achr6165956927-ENST00000262193PSMB1chr6170846428-5621660458152
ENST00000539869PDE10Achr6165956927-ENST00000262193PSMB1chr6170846428-64825238544168
ENST00000366882PDE10Achr6165956928-ENST00000262193PSMB1chr6170846428-717321116613165
ENST00000354448PDE10Achr6165956928-ENST00000262193PSMB1chr6170846428-5621660458152
ENST00000539869PDE10Achr6165956928-ENST00000262193PSMB1chr6170846428-64825238544168

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366882ENST00000262193PDE10Achr6165956927-PSMB1chr6170846428-0.0027767120.99722326
ENST00000354448ENST00000262193PDE10Achr6165956927-PSMB1chr6170846428-0.0035371940.9964629
ENST00000539869ENST00000262193PDE10Achr6165956927-PSMB1chr6170846428-0.0027867660.9972133
ENST00000366882ENST00000262193PDE10Achr6165956928-PSMB1chr6170846428-0.0027767120.99722326
ENST00000354448ENST00000262193PDE10Achr6165956928-PSMB1chr6170846428-0.0035371940.9964629
ENST00000539869ENST00000262193PDE10Achr6165956928-PSMB1chr6170846428-0.0027867660.9972133

Top

Fusion Genomic Features for PDE10A-PSMB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PDE10A-PSMB1


check button Go to

FGviewer for the breakpoints of chr6:165956927-chr6:170846428

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE10Achr6:165956927chr6:170846428ENST00000354448-222266_41255.333333333333336780.0DomainNote=GAF 2
HgenePDE10Achr6:165956927chr6:170846428ENST00000354448-222442_75955.333333333333336780.0DomainPDEase
HgenePDE10Achr6:165956927chr6:170846428ENST00000354448-22291_23455.333333333333336780.0DomainNote=GAF 1
HgenePDE10Achr6:165956927chr6:170846428ENST00000366882-323266_41255.333333333333336780.0DomainNote=GAF 2
HgenePDE10Achr6:165956927chr6:170846428ENST00000366882-323442_75955.333333333333336780.0DomainPDEase
HgenePDE10Achr6:165956927chr6:170846428ENST00000366882-32391_23455.333333333333336780.0DomainNote=GAF 1
HgenePDE10Achr6:165956927chr6:170846428ENST00000539869-222266_41265.33333333333333790.0DomainNote=GAF 2
HgenePDE10Achr6:165956927chr6:170846428ENST00000539869-222442_75965.33333333333333790.0DomainPDEase
HgenePDE10Achr6:165956927chr6:170846428ENST00000539869-22291_23465.33333333333333790.0DomainNote=GAF 1
HgenePDE10Achr6:165956928chr6:170846428ENST00000354448-222266_41255.333333333333336780.0DomainNote=GAF 2
HgenePDE10Achr6:165956928chr6:170846428ENST00000354448-222442_75955.333333333333336780.0DomainPDEase
HgenePDE10Achr6:165956928chr6:170846428ENST00000354448-22291_23455.333333333333336780.0DomainNote=GAF 1
HgenePDE10Achr6:165956928chr6:170846428ENST00000366882-323266_41255.333333333333336780.0DomainNote=GAF 2
HgenePDE10Achr6:165956928chr6:170846428ENST00000366882-323442_75955.333333333333336780.0DomainPDEase
HgenePDE10Achr6:165956928chr6:170846428ENST00000366882-32391_23455.333333333333336780.0DomainNote=GAF 1
HgenePDE10Achr6:165956928chr6:170846428ENST00000539869-222266_41265.33333333333333790.0DomainNote=GAF 2
HgenePDE10Achr6:165956928chr6:170846428ENST00000539869-222442_75965.33333333333333790.0DomainPDEase
HgenePDE10Achr6:165956928chr6:170846428ENST00000539869-22291_23465.33333333333333790.0DomainNote=GAF 1
HgenePDE10Achr6:165956927chr6:170846428ENST00000354448-222286_28755.333333333333336780.0Region3'%2C5'-cAMP binding
HgenePDE10Achr6:165956927chr6:170846428ENST00000354448-222330_33155.333333333333336780.0Region3'%2C5'-cAMP binding
HgenePDE10Achr6:165956927chr6:170846428ENST00000366882-323286_28755.333333333333336780.0Region3'%2C5'-cAMP binding
HgenePDE10Achr6:165956927chr6:170846428ENST00000366882-323330_33155.333333333333336780.0Region3'%2C5'-cAMP binding
HgenePDE10Achr6:165956927chr6:170846428ENST00000539869-222286_28765.33333333333333790.0Region3'%2C5'-cAMP binding
HgenePDE10Achr6:165956927chr6:170846428ENST00000539869-222330_33165.33333333333333790.0Region3'%2C5'-cAMP binding
HgenePDE10Achr6:165956928chr6:170846428ENST00000354448-222286_28755.333333333333336780.0Region3'%2C5'-cAMP binding
HgenePDE10Achr6:165956928chr6:170846428ENST00000354448-222330_33155.333333333333336780.0Region3'%2C5'-cAMP binding
HgenePDE10Achr6:165956928chr6:170846428ENST00000366882-323286_28755.333333333333336780.0Region3'%2C5'-cAMP binding
HgenePDE10Achr6:165956928chr6:170846428ENST00000366882-323330_33155.333333333333336780.0Region3'%2C5'-cAMP binding
HgenePDE10Achr6:165956928chr6:170846428ENST00000539869-222286_28765.33333333333333790.0Region3'%2C5'-cAMP binding
HgenePDE10Achr6:165956928chr6:170846428ENST00000539869-222330_33165.33333333333333790.0Region3'%2C5'-cAMP binding


Top

Fusion Gene Sequence for PDE10A-PSMB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000366882_ENST00000262193_TCGA-E2-A1LE_PDE10A_chr6_165956927_-_PSMB1_chr6_170846428_length(transcript)=717nt_BP=321nt
CCAGGCGGCGGCGGCCAAACTCCGCGGCGTCCCCAGGGCGCCAGCTTCGCCCTCGCCGCCGCGGCCGCGCTGCTCTTCGGCTCCGACATG
GAAGATGGACCTTCTAATAATGCGAGCTGCTTCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAAATGAGGATAGAAGAGAGGAAATCCC
AACATTTAACAGGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTAGATGAATTTGTATCTGAAAGTGTTA
GTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTATACAGCTTTGATCCAGTAGGGTCTT
ACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAACCAGGTTGGTTTTAAGAACATGCAGA
ATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCTGCGGCTGAGAGAGATGTGTACACTG
GGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGGAAGGACTGATCTGTGTGCTCTTATC

>In-frame_ENST00000366882_ENST00000262193_TCGA-E2-A1LE_PDE10A_chr6_165956927_-_PSMB1_chr6_170846428_length(amino acids)=165AA_start in transcript=116_stop in transcript=613
MLPKADRVLPEPQMRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEGKGAVYSFDPVGSYQRDSFKAG

--------------------------------------------------------------
>In-frame_ENST00000354448_ENST00000262193_TCGA-E2-A1LE_PDE10A_chr6_165956927_-_PSMB1_chr6_170846428_length(transcript)=562nt_BP=166nt
ATGAGGATAGAAGAGAGGAAATCCCAACATTTAACAGGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTA
GATGAATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTA
TACAGCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAAC
CAGGTTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCT
GCGGCTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGG
AAGGACTGATCTGTGTGCTCTTATCACCAATCAGTTCAGACCTGGTTGATTTTGTACTTTGGAACTGTACCTTGGATGGTTTTGTTTATT

>In-frame_ENST00000354448_ENST00000262193_TCGA-E2-A1LE_PDE10A_chr6_165956927_-_PSMB1_chr6_170846428_length(amino acids)=152AA_start in transcript=0_stop in transcript=458
MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDN

--------------------------------------------------------------
>In-frame_ENST00000539869_ENST00000262193_TCGA-E2-A1LE_PDE10A_chr6_165956927_-_PSMB1_chr6_170846428_length(transcript)=648nt_BP=252nt
CCCAGGGCGCCAGCTTCGCCCTCGCCGCCGCGGCCGCGCTGCTCTTCGGCTCCGACATGGAAGATGGACCTTCTAATAATGCGAGCTGCT
TCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTAGATG
AATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTATACA
GCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAACCAGG
TTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCTGCGG
CTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGGAAGG
ACTGATCTGTGTGCTCTTATCACCAATCAGTTCAGACCTGGTTGATTTTGTACTTTGGAACTGTACCTTGGATGGTTTTGTTTATTAAAA

>In-frame_ENST00000539869_ENST00000262193_TCGA-E2-A1LE_PDE10A_chr6_165956927_-_PSMB1_chr6_170846428_length(amino acids)=168AA_start in transcript=38_stop in transcript=544
MLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEGKGAVYSFDPVGSYQRDSF

--------------------------------------------------------------
>In-frame_ENST00000366882_ENST00000262193_TCGA-E2-A1LE-01A_PDE10A_chr6_165956928_-_PSMB1_chr6_170846428_length(transcript)=717nt_BP=321nt
CCAGGCGGCGGCGGCCAAACTCCGCGGCGTCCCCAGGGCGCCAGCTTCGCCCTCGCCGCCGCGGCCGCGCTGCTCTTCGGCTCCGACATG
GAAGATGGACCTTCTAATAATGCGAGCTGCTTCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAAATGAGGATAGAAGAGAGGAAATCCC
AACATTTAACAGGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTAGATGAATTTGTATCTGAAAGTGTTA
GTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTATACAGCTTTGATCCAGTAGGGTCTT
ACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAACCAGGTTGGTTTTAAGAACATGCAGA
ATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCTGCGGCTGAGAGAGATGTGTACACTG
GGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGGAAGGACTGATCTGTGTGCTCTTATC

>In-frame_ENST00000366882_ENST00000262193_TCGA-E2-A1LE-01A_PDE10A_chr6_165956928_-_PSMB1_chr6_170846428_length(amino acids)=165AA_start in transcript=116_stop in transcript=613
MLPKADRVLPEPQMRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEGKGAVYSFDPVGSYQRDSFKAG

--------------------------------------------------------------
>In-frame_ENST00000354448_ENST00000262193_TCGA-E2-A1LE-01A_PDE10A_chr6_165956928_-_PSMB1_chr6_170846428_length(transcript)=562nt_BP=166nt
ATGAGGATAGAAGAGAGGAAATCCCAACATTTAACAGGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTA
GATGAATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTA
TACAGCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAAC
CAGGTTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCT
GCGGCTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGG
AAGGACTGATCTGTGTGCTCTTATCACCAATCAGTTCAGACCTGGTTGATTTTGTACTTTGGAACTGTACCTTGGATGGTTTTGTTTATT

>In-frame_ENST00000354448_ENST00000262193_TCGA-E2-A1LE-01A_PDE10A_chr6_165956928_-_PSMB1_chr6_170846428_length(amino acids)=152AA_start in transcript=0_stop in transcript=458
MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDN

--------------------------------------------------------------
>In-frame_ENST00000539869_ENST00000262193_TCGA-E2-A1LE-01A_PDE10A_chr6_165956928_-_PSMB1_chr6_170846428_length(transcript)=648nt_BP=252nt
CCCAGGGCGCCAGCTTCGCCCTCGCCGCCGCGGCCGCGCTGCTCTTCGGCTCCGACATGGAAGATGGACCTTCTAATAATGCGAGCTGCT
TCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTAGATG
AATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTATACA
GCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAACCAGG
TTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCTGCGG
CTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGGAAGG
ACTGATCTGTGTGCTCTTATCACCAATCAGTTCAGACCTGGTTGATTTTGTACTTTGGAACTGTACCTTGGATGGTTTTGTTTATTAAAA

>In-frame_ENST00000539869_ENST00000262193_TCGA-E2-A1LE-01A_PDE10A_chr6_165956928_-_PSMB1_chr6_170846428_length(amino acids)=168AA_start in transcript=38_stop in transcript=544
MLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEGKGAVYSFDPVGSYQRDSF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PDE10A-PSMB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PDE10A-PSMB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PDE10A-PSMB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDE10AC4310791STRIATAL DEGENERATION, AUTOSOMAL DOMINANT 22CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgenePDE10AC4310792DYSKINESIA, LIMB AND OROFACIAL, INFANTILE-ONSET2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgenePDE10AC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgenePDE10AC0005586Bipolar Disorder1PSYGENET
HgenePDE10AC0033975Psychotic Disorders1PSYGENET
HgenePDE10AC0349204Nonorganic psychosis1PSYGENET
TgenePSMB1C0029408Degenerative polyarthritis1CTD_human
TgenePSMB1C0086743Osteoarthrosis Deformans1CTD_human
TgenePSMB1C0948089Acute Coronary Syndrome1CTD_human
TgenePSMB1C4721453Peripheral Nervous System Diseases1CTD_human