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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDE3B-PLCXD3 (FusionGDB2 ID:63280)

Fusion Gene Summary for PDE3B-PLCXD3

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE3B-PLCXD3
Fusion gene ID: 63280
HgeneTgene
Gene symbol

PDE3B

PLCXD3

Gene ID

5140

345557

Gene namephosphodiesterase 3Bphosphatidylinositol specific phospholipase C X domain containing 3
SynonymsHcGIP1|cGIPDE1-
Cytomap

11p15.2

5p13.1

Type of geneprotein-codingprotein-coding
DescriptioncGMP-inhibited 3',5'-cyclic phosphodiesterase BCGI-PDE BCGIP1cyclic GMP-inhibited phosphodiesterase Bcyclic nucleotide phosphodiesterasephosphodiesterase 3B, cGMP-inhibitedPI-PLC X domain-containing protein 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000282096, ENST00000455098, 
ENST00000534317, 		ENST00000377801, 
ENST00000328457, 
Fusion gene scores* DoF score10 X 6 X 6=3607 X 6 X 4=168
# samples 109
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDE3B [Title/Abstract] AND PLCXD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDE3B(14889304)-PLCXD3(41313872), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PDE3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PLCXD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-GN-A8LN-01APDE3Bchr11

14889304

+PLCXD3chr5

41313872

-
ChimerDB4SKCMTCGA-GN-A8LN-01APDE3Bchr11

14889304

-PLCXD3chr5

41313872

-


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Fusion Gene ORF analysis for PDE3B-PLCXD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000282096ENST00000377801PDE3Bchr11

14889304

+PLCXD3chr5

41313872

-
In-frameENST00000282096ENST00000328457PDE3Bchr11

14889304

+PLCXD3chr5

41313872

-
In-frameENST00000455098ENST00000377801PDE3Bchr11

14889304

+PLCXD3chr5

41313872

-
In-frameENST00000455098ENST00000328457PDE3Bchr11

14889304

+PLCXD3chr5

41313872

-
intron-3CDSENST00000534317ENST00000377801PDE3Bchr11

14889304

+PLCXD3chr5

41313872

-
intron-3CDSENST00000534317ENST00000328457PDE3Bchr11

14889304

+PLCXD3chr5

41313872

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000282096PDE3Bchr1114889304+ENST00000377801PLCXD3chr541313872-10309349235335081051
ENST00000282096PDE3Bchr1114889304+ENST00000328457PLCXD3chr541313872-10116349235335081051
ENST00000455098PDE3Bchr1114889304+ENST00000377801PLCXD3chr541313872-10048323124532471000
ENST00000455098PDE3Bchr1114889304+ENST00000328457PLCXD3chr541313872-9855323124532471000

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282096ENST00000377801PDE3Bchr1114889304+PLCXD3chr541313872-0.0002325560.9997675
ENST00000282096ENST00000328457PDE3Bchr1114889304+PLCXD3chr541313872-0.0002276630.99977237
ENST00000455098ENST00000377801PDE3Bchr1114889304+PLCXD3chr541313872-0.0003819720.99961805
ENST00000455098ENST00000328457PDE3Bchr1114889304+PLCXD3chr541313872-0.0003758980.99962413

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Fusion Genomic Features for PDE3B-PLCXD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDE3B-PLCXD3


check button Go to

FGviewer for the breakpoints of chr11:14889304-chr5:41313872

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE3Bchr11:14889304chr5:41313872ENST00000282096+1516117_1371046.33333333333331113.0TransmembraneHelical
HgenePDE3Bchr11:14889304chr5:41313872ENST00000282096+1516152_1721046.33333333333331113.0TransmembraneHelical
HgenePDE3Bchr11:14889304chr5:41313872ENST00000282096+1516192_2121046.33333333333331113.0TransmembraneHelical
HgenePDE3Bchr11:14889304chr5:41313872ENST00000282096+1516220_2401046.33333333333331113.0TransmembraneHelical
HgenePDE3Bchr11:14889304chr5:41313872ENST00000282096+1516247_2671046.33333333333331113.0TransmembraneHelical
HgenePDE3Bchr11:14889304chr5:41313872ENST00000282096+151688_1081046.33333333333331113.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE3Bchr11:14889304chr5:41313872ENST00000282096+15161077_10801046.33333333333331113.0Compositional biasNote=Poly-Glu
HgenePDE3Bchr11:14889304chr5:41313872ENST00000282096+1516651_10791046.33333333333331113.0DomainPDEase
TgenePLCXD3chr11:14889304chr5:41313872ENST000003284571422_197270.66666666666672225.3333333333335DomainPI-PLC X-box
TgenePLCXD3chr11:14889304chr5:41313872ENST000003778011322_197270.6666666666667322.0DomainPI-PLC X-box


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Fusion Gene Sequence for PDE3B-PLCXD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000282096_ENST00000377801_TCGA-GN-A8LN-01A_PDE3B_chr11_14889304_+_PLCXD3_chr5_41313872_length(transcript)=10309nt_BP=3492nt
GCTCGCGCGCCCAACGGACCAGGCTGGGGCCGTGAGGTAACTGTTGCAGCCAGCGGAGGTGGGAGGCGACACTGAGTCTCCAGTCCCGAG
AGGTGCCCGAGGGAAAAGGAGGCGGCAGCTAAACTGGTCCTGGAGAGAAGCCCCTTCCGCCCCTCTCCTCAGCCAGCATGTCCCGGACTC
CGCCGCTCCTCAGTCCGCGCGGTGGGGACCCCGGGCCGTGGCGGCCGGCGCAGCCCTGACGGGTTGCGAACCAGGGGGCGCCCCGAACGC
GGGGGTTGGGGTCTGGGAGCGCGAGCGGCCGCTACGGTACGAGCGGGGTGTGCTGAGTCCCGTGGCCACCCCCGGCCCCAGCCATGAGGA
GGGACGAGCGAGACGCCAAAGCCATGCGGTCCCTGCAGCCGCCGGATGGGGCCGGCTCGCCCCCCGAGAGTCTGAGGAACGGCTACGTGA
AGAGCTGCGTGAGCCCCTTGCGGCAGGACCCTCCGCGCGGCTTCTTCTTCCACCTCTGCCGCTTCTGCAACGTGGAGCTGCGGCCGCCGC
CGGCCTCTCCCCAGCAGCCGCGGCGCTGCTCCCCCTTCTGCCGGGCGCGCCTCTCGCTGGGCGCCCTGGCTGCCTTTGTCCTCGCCCTGC
TGCTGGGCGCGGAACCCGAGAGCTGGGCTGCCGGGGCCGCCTGGCTGCGGACGCTGCTGAGCGTGTGTTCGCACAGCTTGAGCCCCCTCT
TCAGCATCGCCTGTGCCTTCTTCTTCCTCACCTGCTTCCTCACCCGGACCAAGCGGGGACCCGGCCCGGGCCGGAGCTGCGGCTCCTGGT
GGCTGCTGGCGCTGCCCGCCTGCTGTTACCTGGGGGACTTCTTGGTGTGGCAGTGGTGGTCTTGGCCTTGGGGGGATGGCGACGCAGGGT
CCGCGGCCCCGCACACGCCCCCGGAGGCGGCAGCGGGCAGGTTGCTGCTGGTGCTGAGCTGCGTAGGGCTGCTGCTGACGCTCGCGCACC
CGCTGCGGCTCCGGCACTGCGTTCTGGTGCTGCTCCTGGCCAGCTTCGTCTGGTGGGTCTCCTTCACCAGCCTCGGGTCGCTGCCCTCCG
CCCTCAGGCCGCTGCTCTCCGGCCTGGTGGGGGGCGCTGGCTGCCTGCTGGCCCTGGGGTTGGATCACTTCTTTCAAATCAGGGAAGCGC
CTCTTCATCCTCGACTGTCCAGTGCCGCCGAAGAAAAAGTGCCTGTGATCCGACCCCGGAGGAGGTCCAGCTGCGTGTCGTTAGGAGAAA
CTGCAGCCAGTTACTATGGCAGTTGCAAAATATTCAGGAGACCGTCGTTGCCTTGTATTTCCAGAGAACAGATGATTCTTTGGGATTGGG
ACTTAAAACAATGGTATAAGCCTCATTATCAAAATTCTGGAGGTGGAAATGGAGTTGATCTTTCAGTGCTAAATGAGGCTCGCAATATGG
TGTCAGATCTTCTGACTGATCCAAGCCTTCCACCACAAGTCATTTCCTCTCTACGGAGTATTAGTAGCTTAATGGGTGCTTTCTCAGGTT
CCTGTAGGCCAAAGATTAATCCTCTCACACCATTTCCTGGATTTTACCCCTGTTCTGAAATAGAGGACCCAGCTGAGAAAGGGGATAGAA
AACTTAACAAGGGACTAAATAGGAATAGTTTGCCAACTCCACAGCTGAGGAGAAGCTCAGGAACTTCAGGATTGCTACCTGTTGAACAGT
CTTCAAGGTGGGATCGTAATAATGGCAAAAGACCTCACCAAGAATTTGGCATTTCAAGTCAAGGATGCTATCTAAATGGGCCTTTTAATT
CAAATCTACTGACTATCCCGAAGCAAAGGTCATCTTCTGTATCACTGACTCACCATGTAGGTCTCAGAAGAGCTGGTGTTTTGTCCAGTC
TGAGTCCTGTGAATTCTTCCAACCATGGACCAGTGTCTACTGGCTCTCTAACTAATCGATCACCCATAGAATTTCCTGATACTGCTGATT
TTCTTAATAAGCCAAGCGTTATCTTGCAGAGATCTCTGGGCAATGCACCTAATACTCCAGATTTTTATCAGCAACTTAGAAATTCTGATA
GCAATCTGTGTAACAGCTGTGGACATCAAATGCTGAAATATGTTTCAACATCTGAATCAGATGGTACAGATTGCTGCAGTGGAAAATCAG
GTGAAGAAGAAAACATTTTCTCGAAAGAATCATTCAAACTTATGGAAACTCAACAAGAAGAGGAAACAGAGAAGAAAGACAGCAGAAAAT
TATTTCAGGAAGGTGATAAGTGGCTAACAGAAGAGGCACAGAGTGAACAGCAAACAAATATTGAACAGGAAGTATCACTGGACCTGATTT
TAGTAGAAGAGTATGACTCATTAATAGAAAAGATGAGCAACTGGAATTTTCCAATTTTTGAACTTGTAGAAAAGATGGGAGAGAAATCAG
GAAGGATTCTCAGTCAGGTTATGTATACCTTATTTCAAGACACTGGTTTATTGGAAATATTTAAAATTCCCACTCAACAATTTATGAACT
ATTTTCGTGCATTAGAAAATGGCTATCGAGACATTCCTTATCACAATCGTATACATGCCACAGATGTGCTACATGCAGTTTGGTATCTGA
CAACACGGCCAGTTCCTGGCTTACAGCAGATCCACAATGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATTAACCATGGGC
GAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCTGCATTAGAATTGATGG
CTCTATACGTGGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCTCAGGCAGTTT
TATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAATACAACTTCCTTCTTC
ATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTTGATTTTCTCG
CAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTGGTATGCCAGGTGTGCA
TCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTTTATGAGCAGG
GAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTCCAAGAATCTTTTATCA
CCCACATAGTGGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGATAATGATACTG
AAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAGCTCTTCCTGCCATGAT
GCAGTGGGTCCGCACGCAGAAGCCAGGAGAGAGTGGCATCAATATTGTCACTGCCGATTTTGTAGAACTTGGTGACTTTATCAGCACTGT
CATAAAGCTCAACTATGTCTTTGATGAAGGAGAAGCCAACACTTGATAGCACTACTTGGAGTTTCCATGAATAAGATGGAGAAAGCTCAT
TGTATTAGGGCATACTATCTGTAAACACTCTGATCTTCCTATTCCACTGAGTCTCTGAAGGGAATAGGGCTGGTAGTGGGTGGGAAAAGG
GGAAAAACTGTTTCTTCAGTGATTACAATCATACTCTTCATTACTATAAATATTTCATTTCCCATTTGATGAGCAAAATCTACTTCTAGT
GTTAGGAATAAAAAAAAAAGACCAGTAACTTTGTTTTTCAAAATTAGTCTTTGTAACATAGAATTCATGAGTGTTTACTTGATTAGGTTC
TCTATTTCCAGCCTATGACTCCTACGCTGTCTATACCCTGCAACCTTTCTGCTCCCTCTCTTGCTCGCTCTTTTTAATCAGATGCTGTAT
GGGAATCAAAACAATTGAATGCCCAACATTTTGTGTATTACATTGTTGTCTTAAAACTTACTAGTTTTGTGGGACTTGTTATAATGCTCT
ATAGTCATCCACAGTTGGGCAATCATAGCTAATTTTTGGTCATAGAAAATCTGCATCAAATCAGTTTCCATGCATCAGTAATATTGAAGG
TCATAATCAGTGATTTTTGTTATATGAAAATAATAGTGTTTCACAGTATTTCTATTTAAGGCAGCTATAAATATAGGAGAAAAATGTTTT
TGGAGAGCTGTGAATGCCAATTTCAGAGGGAAAAATGGTTGAGGGGTGAAAGAGATGTATGGCATTTTAATTTGGCAATCTCTTAAATAA
TATTGCCCTGCAAGTACCCAGTAAATGGTAAGGTACAAGTGTGTTAAAATTGAAAACTCTGAAAATAACTCTTTAAAAAGCCCTCTTAAT
GATGCTCTTGATGAAAGAAAAAGACAGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAAGGAAGAAAGGAA
GGGAGGGAGGAAGGGAGGGAAGAAGGGAGGGAAGGACAGAAGGAAGGACGGGAGGAAGGAAGGAAGGGAGGAAGGAAGGAAGGAAGAGAG
GGAGGGAGGGAGGAAGAGAGGGAGGGAGGGAGGAAGAGAGGAAGGAAGAAGAAAAAGACTGCAAGCTTTCCTGCCAATTTGGGATTTTCA
AATATTTAATTCTAAATTCCAGATTTTAAGGAAGATTTTTCAAGAAACTGCAAGTTTTTGACTTGAAGGAAAGAAAGAGGAAGGCTGGTA
GAAGCAGTTAGAGCAATGTGTTTGAAATTATGTCCATGAAATCACAGGGATCTCTGAAATATCTTTAGGAAACTTGAAATTTATGAGGTC
TGAATGGACTTGTTTAAAATTGGCTCTGACTCCTCACTTCTGAGTTTCATCCTATCCGAGGGATGAGATTAAGGCAGAGGCAAAAGTTTC
ACACAAAGTTTCTGCAACCTAACGTTTAATAGTCCGGGTCTACAGGGAAGAACAATGACACAGCTTGAGCGTTACTTCCTCCTTCGTGTC
ATTGTGATATTTGACAACTCTAAAAAATAAAAAAAAAAAACTTAGAGCACAATAATCCTTGCCTATGTACTTCACAGGAATATTGTGAGG
TGTTTATAAAATTATAAAATTTGATGAAATTCTTACAATTATTAATTATTTTATTTTCATGTTTAGAAATAATCACACCCCAATAGTTTC
CTAGGATAATACAGTCCATGCAAAGTAGGGTCATAGAGAAATAAAAGCATGCCCTCAGCTTTTAATGAACTTAAATGTAGCACATATGGC
TTAATCTCTTAGACTTAGATAAGGGAGTTCAATTCAAAACCATATATGTCAAGACCACAAATAATCAAGAGTTGATTTCAAGATTATAAA
TACTCATGATCAGAAAATAGTACTTATTAGCAATTAAAGGGAGGAAAAGAAATTGTTTATACTGAAGAGAATGTTTATGAGGAGTGTGTA
TGTACCTGTGGTATACCAAATAGCATACATGTACACACAAAAATGTGTGTATACATTTGGGTTGTGTGTATACATCTTGCCATATACAAT
ATACAAACATATGCCCATTCCTGTGATAGCATACAAATTCAAACATACAGAAACACACACAGATATGGACACAGTACAATTCTTCTTTTC
AAATGAAGACATTGATAATATTAAATAATTTAATTTTAAGACTGAAACCCTTAATATTGTGTGAAAAAGAGTAATAAAACCTTTGAAAGT
AGAGTAGATGATCACATCAAAGTATTTTTGTAAAAGAATTCTAGTGTAGGACTTAATTATTTTTAAAATATATTTCTTCTCTTCTTTCCA
TTTTCCCTTCCCTTGTAGTTTTATTATCTTTCTGTCTTTTACACCTGCTCTTTATGTGAAAATGTATATGAATCCTTTTAAAATGATTAG
GATTATTGAAATGTATGTCCCGTAAATTTGGTTTTTGGGCAGACTTTCTCTCTAACTGGCTATTCATTCATCCTTCAGGAGGATCTTAGC
CAAGAATATTTGCAATGACACATGAATTTAATTTTATAAATATAATGGAAAACAGATTTTTCATCATATCATGAATAAAATATAGAGGTA
ACTATGTTGTATTTTCTTGAACCTAGATACTTTCTCATAGTGTTTGCTTAGAATTAACTTTGTCCTATTTGTCAACTGGGTTCTGGAAAA
AAACAAACATGATGAAGCTTTTGAATAATTGTGCAGTTTTTTAACTAGGGAAAGCTTTGTACTGCTGCTAATGATATGCACCCAGAAACC
TTGTTAGACAAAAGGCAGTTTCAAGCCAATGCTATGGTTTCCATGTGGACATACAGTGCCTATGTAGCAGGCACTTAGAGTAAATGGACT
TGCCTTAATTTATAAAGGAGGGAAGAGGTAGAAGGGAACCATGGGTCCTCCAGCTAGAGGGGGAGTTTACTAAAAGGGAGTCCTTGGAAA
GGGGAATGGAGAGAAGGTGCCTTTGACTGTCTTCTATCCATTAGTTCTGCCCTGGAGCACACTGGGGAAGCAGGCTGCGGGCCTTCCAAA
AGTAAAAAATGGTGATATGCAATCGAAGCTTATCCTTAGCCTATGCACATTTGTCTCAGCTGGGCATTGTCTTTTCAGAGAGCTTGTAGC
ACAAGGGCTACACATGGGCGCCAAGATGGTGGTAGATACACCTTGGTGCACTTTTTGTTTTACTTGTTTCTTAAGACTATTTCACAAGTC
CTGTGAGGCAAAAAAACAAAACAAAACAAAACAACCAAACAAATACAATCTAACTTTTACCCAATCTACAGCAGGAAATCAAAGGAGTGG
GTGGAATGAGAGAAAATATGCAAAGAGATCATTTTTAAGTTTGATTTCCTGTCTGTAATTTTCAAGGACTAATATAGCAAATTTTTCTTC
TGCCATTATCATTTATGTCTCCCTATTTACCACACAATAATGTAAATGCAGAGAATGAGGAGGCATCTTTTAAAAGCCTTAGGATATTCT
ATATGATGACCTCAATATTGACTTTCAGCCATACTGGGAAAACTTACTTTTCATGGAGTGCCACCTAACAGTGAATGTATTAGAGTATAA
AATGTTTGCCATGTATACACCTGTATGTGCACATACACACATTACACACACACACAGAATGCACATTTCACACACATATACTTATTATTC
AAGTTGAAACTGCACTCTAATCAATCTGAGTCTATTGCTGTTTCAACTCTTAAAATCAATATCTCCTACATTAGTAGATATAAACATAAT
TCAAATATTTAAATATTTAAGAGGAGAAAAGTAACTAGAAAACCAATGAAAAGTGAGGCCATCAGAAATAGAAAATGCCTGGCACGAACA
GTCTATCTAAATTCTCAATTTCACTTCAAATTAGAGAATCCATAATGGACTAGAATATAAATTACAAACACATACACACATCTTCACTTA
AAGTTGTTTTAAGTTCTTTGAAGTTCTGACATGTTTTTAGCCAGGGTTATTTGTTCAGGTTCTTCCTTGTTAGGATTCCAGACTGGAAAG
TTGGAAGTCTCAGGAAATGCATGTTTCCATGAGTTTTTTAGTTTCACAGTTTTACAGATCCAACGACACAATCTTTTAATCTTTGGTCAC
TCAACCAAACAGGAGTTCCGTAGGCAGAGTGCTCACTTTGAATTGCTAATAGAAAATAATGCACAGTGTCCTCAGGATATGCTAAACAAG
GTTTTTAAGAGCATTTTATTTTACAGCACTTTAGTCTTTTCAGCTAGATTTCAGTGACACTATGGTGTAAATGCTATATCTGCCATAACT
TATTGGTGGCTCCTGTGTTACATACAGTTTTAAATAATGCTCTAAATTGTTTGTTTTCCCAATGATAATGATAAAGTGTTCTGTAGAATT
TGTAAAACATGTCAATTGAATCTGTTGAAAATTGTGTAATTGTTATTTCAATTGTGATACTATTTTGTAGGTAATAGTTTTAAACGTATA
TTTGTATGAGTCAAAAGTATGTGCTTGTATGTGGTATGTGTGTGTAAGTATATAATATCTTATCAAAAATCAAACTTATCCTAAAGAAAA
AGGGCACATTGTGACCAGCCTTAATTTATTAACACTTTTTTGTTGTTTTTGCAATTTGGATTTAAAATTGAAACAGAAATTAAGTTTTTG
TTAAAAATGGTGTCTTTTAATTTTGTGAGGAATGGGCTTTAGAACCTATCTGAGTTCCCACAAGCAAACTGTCCACCTTGTGAGGTACCC
CATTGCTTTTCGTAATAATCAAACATCAATTCATATATTAACTTCATTTTCATACAGACTAATTTGTTTTCATCAACAATAGAACCAGTA
CACCTTTAAAGTTGACCTTCCCAACATGGCACCCATTTTTCTTTAATGATAAATTTTCCATGAAAAATTGTTTCTCCAAACCATTACTTT
TTAAAATTCAATCTTCCCAAGTAAGATGAACTGCCTTGGTGTTAGGAGAGCTTTTAAAGGCCCATCCATACTAGGTGGTTCCAACATGGT
TCTCTTCTCGAGAAAACAAGCATGCAACCCACACACTTTTCTGGTCTGCCCCACGTGTAGAATTAGTCTAGCAATAGAAAACTCATGACT
GACAAGGATCTACACATGTGGTCATGCTTGAAGCAAAAATTCTGTGACCTTCTTTGGGCTTGGATCTGATTACAGAATATTAATTAACTT
TCTTATTTCCTTTCTTTCTCCATCCTTAGTTATTCCTTTTCAATATTTAGAGTTGCCAGGTAAAATACAGGATATCCAGTGAAATTTAAA
TTTCAGATAAACAGTATTTCTTTAGCATATTTCTCATATATTTAATCAGACATACTTTCACTTTAAAAAAAGTTTATCTGAAATTCAAAT
GTAACTGGGTATGTCCTATATATTTTTTCCTAAATCTCACAATTCTATCCACACTGCCTTTCTATCTTTTTCAGCTGGGCTATCTATAAG
GGGCGAGATCTACCTCCCTCCATACCCTTGTGTTCAGACACCTTATGAATATCTGCAGTCATAATGTCCTTCAAGAAAGAAAACATTGGT
CAGCTCTAGGTCCTGCAAATGCTTTTTGAAGGACGAACTCAAATACAGATGGGATAATCAAGTAAATATCTTCATAGGATCAATGCCACC
ATGTTCAACACTTCCCTTTGCCAGCCTGTTGTGAGGTCCAAGTTTCCCCATTAATCCCTTATATAGCATTTCCCAGTAACTGGGACAACC
AAAAACACACCGACATATTAGAAATGCTCCTGAAAAGTGGCAACACCGCCTAACTCAGTACCAGGACCTCTTTTAAATTCAATTTCTTTT
TTCTTTCAGAGAGATAACAAACGAATTCATTATTTCCCCCATTCACATCTTACCACAAATTATTTTTATCAGGTTAAAACTGGTCATCTA
CGGAATTGTAGAAAGGTGACATAGGAACTGTCTTCACTGCTGGAAGAATAAAAGAGTCTGAGGTATAGACACTGCCCTGGTGACACCTTC
TCAGAACATTGTTGGGGGACAGGGGAGGCAGGCGCAAGTAGGGGATAGAATCTGACCCTGACATGCAGCTATCACCTGGCAGAGAGACTC
GTCAAAGCAAATTATAACGACCAGTACTATTTTTTTTTGGAATTGAAAACCCAAGAAGCCCTAAAATAAGAACAGTGAGATCAAAGGCTG
GTTTCTAAAACAATGCAGAAAATAGAACCATGTTGGAATTCCTAAATTCTAGCTTTCAAATACTACTGTTTCCAACAGTGAATCCTTGAC
AGAGACTGAATGCAGATGGAATTTTGAAACATTTTCAGTAGCTACCTCCTCTCCTGAAATTCCTATAAGTGGCAGAGGAAAATCCAAATC
CTTTAATATAACATGTCCATCTCATGACTCCTGCTTACACACATTTGTGTTGATTTGCTTCATTTCTGGAGGATGGGAATTTGCAGAGCT
GGTGACATTTCCTTCATTAGACACCAGAAATTCACCAGAGAGAGACAGATCTGTGCCTTCTCTTTTTAGGATCTGGTTATTGATACTTTA
ATAAATGTGGTGTAAAGAAAATCCATGGCTACAGTCTGTATAGAAAATGTGAATTTTTTAAATAAGATTGTGTTCTTAATGTAAAAAATA

>In-frame_ENST00000282096_ENST00000377801_TCGA-GN-A8LN-01A_PDE3B_chr11_14889304_+_PLCXD3_chr5_41313872_length(amino acids)=1051AA_start in transcript=353_stop in transcript=3508
MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELRPPPASPQQPRRCSPFCRARLSLGALAAFVL
ALLLGAEPESWAAGAAWLRTLLSVCSHSLSPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGD
AGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSLPSALRPLLSGLVGGAGCLLALGLDHFFQIR
EAPLHPRLSSAAEEKVPVIRPRRRSSCVSLGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEAR
NMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGTSGLLPV
EQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDT
ADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEETEKKDS
RKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQF
MNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALE
LMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFD
FLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQES

--------------------------------------------------------------
>In-frame_ENST00000282096_ENST00000328457_TCGA-GN-A8LN-01A_PDE3B_chr11_14889304_+_PLCXD3_chr5_41313872_length(transcript)=10116nt_BP=3492nt
GCTCGCGCGCCCAACGGACCAGGCTGGGGCCGTGAGGTAACTGTTGCAGCCAGCGGAGGTGGGAGGCGACACTGAGTCTCCAGTCCCGAG
AGGTGCCCGAGGGAAAAGGAGGCGGCAGCTAAACTGGTCCTGGAGAGAAGCCCCTTCCGCCCCTCTCCTCAGCCAGCATGTCCCGGACTC
CGCCGCTCCTCAGTCCGCGCGGTGGGGACCCCGGGCCGTGGCGGCCGGCGCAGCCCTGACGGGTTGCGAACCAGGGGGCGCCCCGAACGC
GGGGGTTGGGGTCTGGGAGCGCGAGCGGCCGCTACGGTACGAGCGGGGTGTGCTGAGTCCCGTGGCCACCCCCGGCCCCAGCCATGAGGA
GGGACGAGCGAGACGCCAAAGCCATGCGGTCCCTGCAGCCGCCGGATGGGGCCGGCTCGCCCCCCGAGAGTCTGAGGAACGGCTACGTGA
AGAGCTGCGTGAGCCCCTTGCGGCAGGACCCTCCGCGCGGCTTCTTCTTCCACCTCTGCCGCTTCTGCAACGTGGAGCTGCGGCCGCCGC
CGGCCTCTCCCCAGCAGCCGCGGCGCTGCTCCCCCTTCTGCCGGGCGCGCCTCTCGCTGGGCGCCCTGGCTGCCTTTGTCCTCGCCCTGC
TGCTGGGCGCGGAACCCGAGAGCTGGGCTGCCGGGGCCGCCTGGCTGCGGACGCTGCTGAGCGTGTGTTCGCACAGCTTGAGCCCCCTCT
TCAGCATCGCCTGTGCCTTCTTCTTCCTCACCTGCTTCCTCACCCGGACCAAGCGGGGACCCGGCCCGGGCCGGAGCTGCGGCTCCTGGT
GGCTGCTGGCGCTGCCCGCCTGCTGTTACCTGGGGGACTTCTTGGTGTGGCAGTGGTGGTCTTGGCCTTGGGGGGATGGCGACGCAGGGT
CCGCGGCCCCGCACACGCCCCCGGAGGCGGCAGCGGGCAGGTTGCTGCTGGTGCTGAGCTGCGTAGGGCTGCTGCTGACGCTCGCGCACC
CGCTGCGGCTCCGGCACTGCGTTCTGGTGCTGCTCCTGGCCAGCTTCGTCTGGTGGGTCTCCTTCACCAGCCTCGGGTCGCTGCCCTCCG
CCCTCAGGCCGCTGCTCTCCGGCCTGGTGGGGGGCGCTGGCTGCCTGCTGGCCCTGGGGTTGGATCACTTCTTTCAAATCAGGGAAGCGC
CTCTTCATCCTCGACTGTCCAGTGCCGCCGAAGAAAAAGTGCCTGTGATCCGACCCCGGAGGAGGTCCAGCTGCGTGTCGTTAGGAGAAA
CTGCAGCCAGTTACTATGGCAGTTGCAAAATATTCAGGAGACCGTCGTTGCCTTGTATTTCCAGAGAACAGATGATTCTTTGGGATTGGG
ACTTAAAACAATGGTATAAGCCTCATTATCAAAATTCTGGAGGTGGAAATGGAGTTGATCTTTCAGTGCTAAATGAGGCTCGCAATATGG
TGTCAGATCTTCTGACTGATCCAAGCCTTCCACCACAAGTCATTTCCTCTCTACGGAGTATTAGTAGCTTAATGGGTGCTTTCTCAGGTT
CCTGTAGGCCAAAGATTAATCCTCTCACACCATTTCCTGGATTTTACCCCTGTTCTGAAATAGAGGACCCAGCTGAGAAAGGGGATAGAA
AACTTAACAAGGGACTAAATAGGAATAGTTTGCCAACTCCACAGCTGAGGAGAAGCTCAGGAACTTCAGGATTGCTACCTGTTGAACAGT
CTTCAAGGTGGGATCGTAATAATGGCAAAAGACCTCACCAAGAATTTGGCATTTCAAGTCAAGGATGCTATCTAAATGGGCCTTTTAATT
CAAATCTACTGACTATCCCGAAGCAAAGGTCATCTTCTGTATCACTGACTCACCATGTAGGTCTCAGAAGAGCTGGTGTTTTGTCCAGTC
TGAGTCCTGTGAATTCTTCCAACCATGGACCAGTGTCTACTGGCTCTCTAACTAATCGATCACCCATAGAATTTCCTGATACTGCTGATT
TTCTTAATAAGCCAAGCGTTATCTTGCAGAGATCTCTGGGCAATGCACCTAATACTCCAGATTTTTATCAGCAACTTAGAAATTCTGATA
GCAATCTGTGTAACAGCTGTGGACATCAAATGCTGAAATATGTTTCAACATCTGAATCAGATGGTACAGATTGCTGCAGTGGAAAATCAG
GTGAAGAAGAAAACATTTTCTCGAAAGAATCATTCAAACTTATGGAAACTCAACAAGAAGAGGAAACAGAGAAGAAAGACAGCAGAAAAT
TATTTCAGGAAGGTGATAAGTGGCTAACAGAAGAGGCACAGAGTGAACAGCAAACAAATATTGAACAGGAAGTATCACTGGACCTGATTT
TAGTAGAAGAGTATGACTCATTAATAGAAAAGATGAGCAACTGGAATTTTCCAATTTTTGAACTTGTAGAAAAGATGGGAGAGAAATCAG
GAAGGATTCTCAGTCAGGTTATGTATACCTTATTTCAAGACACTGGTTTATTGGAAATATTTAAAATTCCCACTCAACAATTTATGAACT
ATTTTCGTGCATTAGAAAATGGCTATCGAGACATTCCTTATCACAATCGTATACATGCCACAGATGTGCTACATGCAGTTTGGTATCTGA
CAACACGGCCAGTTCCTGGCTTACAGCAGATCCACAATGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATTAACCATGGGC
GAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCTGCATTAGAATTGATGG
CTCTATACGTGGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCTCAGGCAGTTT
TATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAATACAACTTCCTTCTTC
ATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTTGATTTTCTCG
CAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTGGTATGCCAGGTGTGCA
TCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTTTATGAGCAGG
GAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTCCAAGAATCTTTTATCA
CCCACATAGTGGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGATAATGATACTG
AAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAGCTCTTCCTGCCATGAT
GCAGTGGGTCCGCACGCAGAAGCCAGGAGAGAGTGGCATCAATATTGTCACTGCCGATTTTGTAGAACTTGGTGACTTTATCAGCACTGT
CATAAAGCTCAACTATGTCTTTGATGAAGGAGAAGCCAACACTTGATAGCACTACTTGGAGTTTCCATGAATAAGATGGAGAAAGCTCAT
TGTATTAGGGCATACTATCTGTAAACACTCTGATCTTCCTATTCCACTGAGTCTCTGAAGGGAATAGGGCTGGTAGTGGGTGGGAAAAGG
GGAAAAACTGTTTCTTCAGTGATTACAATCATACTCTTCATTACTATAAATATTTCATTTCCCATTTGATGAGCAAAATCTACTTCTAGT
GTTAGGAATAAAAAAAAAAGACCAGTAACTTTGTTTTTCAAAATTAGTCTTTGTAACATAGAATTCATGAGTGTTTACTTGATTAGGTTC
TCTATTTCCAGCCTATGACTCCTACGCTGTCTATACCCTGCAACCTTTCTGCTCCCTCTCTTGCTCGCTCTTTTTAATCAGATGCTGTAT
GGGAATCAAAACAATTGAATGCCCAACATTTTGTGTATTACATTGTTGTCTTAAAACTTACTAGTTTTGTGGGACTTGTTATAATGCTCT
ATAGTCATCCACAGTTGGGCAATCATAGCTAATTTTTGGTCATAGAAAATCTGCATCAAATCAGTTTCCATGCATCAGTAATATTGAAGG
TCATAATCAGTGATTTTTGTTATATGAAAATAATAGTGTTTCACAGTATTTCTATTTAAGGCAGCTATAAATATAGGAGAAAAATGTTTT
TGGAGAGCTGTGAATGCCAATTTCAGAGGGAAAAATGGTTGAGGGGTGAAAGAGATGTATGGCATTTTAATTTGGCAATCTCTTAAATAA
TATTGCCCTGCAAGTACCCAGTAAATGGTAAGGTACAAGTGTGTTAAAATTGAAAACTCTGAAAATAACTCTTTAAAAAGCCCTCTTAAT
GATGCTCTTGATGAAAGAAAAAGACAGAAGGAAGGAAGAAGAAAAAGACTGCAAGCTTTCCTGCCAATTTGGGATTTTCAAATATTTAAT
TCTAAATTCCAGATTTTAAGGAAGATTTTTCAAGAAACTGCAAGTTTTTGACTTGAAGGAAAGAAAGAGGAAGGCTGGTAGAAGCAGTTA
GAGCAATGTGTTTGAAATTATGTCCATGAAATCACAGGGATCTCTGAAATATCTTTAGGAAACTTGAAATTTATGAGGTCTGAATGGACT
TGTTTAAAATTGGCTCTGACTCCTCACTTCTGAGTTTCATCCTATCCGAGGGATGAGATTAAGGCAGAGGCAAAAGTTTCACACAAAGTT
TCTGCAACCTAACGTTTAATAGTCCGGGTCTACAGGGAAGAACAATGACACAGCTTGAGCGTTACTTCCTCCTTCGTGTCATTGTGATAT
TTGACAACTCTAAAAAATAAAAAAAAAAAACTTAGAGCACAATAATCCTTGCCTATGTACTTCACAGGAATATTGTGAGGTGTTTATAAA
ATTATAAAATTTGATGAAATTCTTACAATTATTAATTATTTTATTTTCATGTTTAGAAATAATCACACCCCAATAGTTTCCTAGGATAAT
ACAGTCCATGCAAAGTAGGGTCATAGAGAAATAAAAGCATGCCCTCAGCTTTTAATGAACTTAAATGTAGCACATATGGCTTAATCTCTT
AGACTTAGATAAGGGAGTTCAATTCAAAACCATATATGTCAAGACCACAAATAATCAAGAGTTGATTTCAAGATTATAAATACTCATGAT
CAGAAAATAGTACTTATTAGCAATTAAAGGGAGGAAAAGAAATTGTTTATACTGAAGAGAATGTTTATGAGGAGTGTGTATGTACCTGTG
GTATACCAAATAGCATACATGTACACACAAAAATGTGTGTATACATTTGGGTTGTGTGTATACATCTTGCCATATACAATATACAAACAT
ATGCCCATTCCTGTGATAGCATACAAATTCAAACATACAGAAACACACACAGATATGGACACAGTACAATTCTTCTTTTCAAATGAAGAC
ATTGATAATATTAAATAATTTAATTTTAAGACTGAAACCCTTAATATTGTGTGAAAAAGAGTAATAAAACCTTTGAAAGTAGAGTAGATG
ATCACATCAAAGTATTTTTGTAAAAGAATTCTAGTGTAGGACTTAATTATTTTTAAAATATATTTCTTCTCTTCTTTCCATTTTCCCTTC
CCTTGTAGTTTTATTATCTTTCTGTCTTTTACACCTGCTCTTTATGTGAAAATGTATATGAATCCTTTTAAAATGATTAGGATTATTGAA
ATGTATGTCCCGTAAATTTGGTTTTTGGGCAGACTTTCTCTCTAACTGGCTATTCATTCATCCTTCAGGAGGATCTTAGCCAAGAATATT
TGCAATGACACATGAATTTAATTTTATAAATATAATGGAAAACAGATTTTTCATCATATCATGAATAAAATATAGAGGTAACTATGTTGT
ATTTTCTTGAACCTAGATACTTTCTCATAGTGTTTGCTTAGAATTAACTTTGTCCTATTTGTCAACTGGGTTCTGGAAAAAAACAAACAT
GATGAAGCTTTTGAATAATTGTGCAGTTTTTTAACTAGGGAAAGCTTTGTACTGCTGCTAATGATATGCACCCAGAAACCTTGTTAGACA
AAAGGCAGTTTCAAGCCAATGCTATGGTTTCCATGTGGACATACAGTGCCTATGTAGCAGGCACTTAGAGTAAATGGACTTGCCTTAATT
TATAAAGGAGGGAAGAGGTAGAAGGGAACCATGGGTCCTCCAGCTAGAGGGGGAGTTTACTAAAAGGGAGTCCTTGGAAAGGGGAATGGA
GAGAAGGTGCCTTTGACTGTCTTCTATCCATTAGTTCTGCCCTGGAGCACACTGGGGAAGCAGGCTGCGGGCCTTCCAAAAGTAAAAAAT
GGTGATATGCAATCGAAGCTTATCCTTAGCCTATGCACATTTGTCTCAGCTGGGCATTGTCTTTTCAGAGAGCTTGTAGCACAAGGGCTA
CACATGGGCGCCAAGATGGTGGTAGATACACCTTGGTGCACTTTTTGTTTTACTTGTTTCTTAAGACTATTTCACAAGTCCTGTGAGGCA
AAAAAACAAAACAAAACAAAACAACCAAACAAATACAATCTAACTTTTACCCAATCTACAGCAGGAAATCAAAGGAGTGGGTGGAATGAG
AGAAAATATGCAAAGAGATCATTTTTAAGTTTGATTTCCTGTCTGTAATTTTCAAGGACTAATATAGCAAATTTTTCTTCTGCCATTATC
ATTTATGTCTCCCTATTTACCACACAATAATGTAAATGCAGAGAATGAGGAGGCATCTTTTAAAAGCCTTAGGATATTCTATATGATGAC
CTCAATATTGACTTTCAGCCATACTGGGAAAACTTACTTTTCATGGAGTGCCACCTAACAGTGAATGTATTAGAGTATAAAATGTTTGCC
ATGTATACACCTGTATGTGCACATACACACATTACACACACACACAGAATGCACATTTCACACACATATACTTATTATTCAAGTTGAAAC
TGCACTCTAATCAATCTGAGTCTATTGCTGTTTCAACTCTTAAAATCAATATCTCCTACATTAGTAGATATAAACATAATTCAAATATTT
AAATATTTAAGAGGAGAAAAGTAACTAGAAAACCAATGAAAAGTGAGGCCATCAGAAATAGAAAATGCCTGGCACGAACAGTCTATCTAA
ATTCTCAATTTCACTTCAAATTAGAGAATCCATAATGGACTAGAATATAAATTACAAACACATACACACATCTTCACTTAAAGTTGTTTT
AAGTTCTTTGAAGTTCTGACATGTTTTTAGCCAGGGTTATTTGTTCAGGTTCTTCCTTGTTAGGATTCCAGACTGGAAAGTTGGAAGTCT
CAGGAAATGCATGTTTCCATGAGTTTTTTAGTTTCACAGTTTTACAGATCCAACGACACAATCTTTTAATCTTTGGTCACTCAACCAAAC
AGGAGTTCCGTAGGCAGAGTGCTCACTTTGAATTGCTAATAGAAAATAATGCACAGTGTCCTCAGGATATGCTAAACAAGGTTTTTAAGA
GCATTTTATTTTACAGCACTTTAGTCTTTTCAGCTAGATTTCAGTGACACTATGGTGTAAATGCTATATCTGCCATAACTTATTGGTGGC
TCCTGTGTTACATACAGTTTTAAATAATGCTCTAAATTGTTTGTTTTCCCAATGATAATGATAAAGTGTTCTGTAGAATTTGTAAAACAT
GTCAATTGAATCTGTTGAAAATTGTGTAATTGTTATTTCAATTGTGATACTATTTTGTAGGTAATAGTTTTAAACGTATATTTGTATGAG
TCAAAAGTATGTGCTTGTATGTGGTATGTGTGTGTAAGTATATAATATCTTATCAAAAATCAAACTTATCCTAAAGAAAAAGGGCACATT
GTGACCAGCCTTAATTTATTAACACTTTTTTGTTGTTTTTGCAATTTGGATTTAAAATTGAAACAGAAATTAAGTTTTTGTTAAAAATGG
TGTCTTTTAATTTTGTGAGGAATGGGCTTTAGAACCTATCTGAGTTCCCACAAGCAAACTGTCCACCTTGTGAGGTACCCCATTGCTTTT
CGTAATAATCAAACATCAATTCATATATTAACTTCATTTTCATACAGACTAATTTGTTTTCATCAACAATAGAACCAGTACACCTTTAAA
GTTGACCTTCCCAACATGGCACCCATTTTTCTTTAATGATAAATTTTCCATGAAAAATTGTTTCTCCAAACCATTACTTTTTAAAATTCA
ATCTTCCCAAGTAAGATGAACTGCCTTGGTGTTAGGAGAGCTTTTAAAGGCCCATCCATACTAGGTGGTTCCAACATGGTTCTCTTCTCG
AGAAAACAAGCATGCAACCCACACACTTTTCTGGTCTGCCCCACGTGTAGAATTAGTCTAGCAATAGAAAACTCATGACTGACAAGGATC
TACACATGTGGTCATGCTTGAAGCAAAAATTCTGTGACCTTCTTTGGGCTTGGATCTGATTACAGAATATTAATTAACTTTCTTATTTCC
TTTCTTTCTCCATCCTTAGTTATTCCTTTTCAATATTTAGAGTTGCCAGGTAAAATACAGGATATCCAGTGAAATTTAAATTTCAGATAA
ACAGTATTTCTTTAGCATATTTCTCATATATTTAATCAGACATACTTTCACTTTAAAAAAAGTTTATCTGAAATTCAAATGTAACTGGGT
ATGTCCTATATATTTTTTCCTAAATCTCACAATTCTATCCACACTGCCTTTCTATCTTTTTCAGCTGGGCTATCTATAAGGGGCGAGATC
TACCTCCCTCCATACCCTTGTGTTCAGACACCTTATGAATATCTGCAGTCATAATGTCCTTCAAGAAAGAAAACATTGGTCAGCTCTAGG
TCCTGCAAATGCTTTTTGAAGGACGAACTCAAATACAGATGGGATAATCAAGTAAATATCTTCATAGGATCAATGCCACCATGTTCAACA
CTTCCCTTTGCCAGCCTGTTGTGAGGTCCAAGTTTCCCCATTAATCCCTTATATAGCATTTCCCAGTAACTGGGACAACCAAAAACACAC
CGACATATTAGAAATGCTCCTGAAAAGTGGCAACACCGCCTAACTCAGTACCAGGACCTCTTTTAAATTCAATTTCTTTTTTCTTTCAGA
GAGATAACAAACGAATTCATTATTTCCCCCATTCACATCTTACCACAAATTATTTTTATCAGGTTAAAACTGGTCATCTACGGAATTGTA
GAAAGGTGACATAGGAACTGTCTTCACTGCTGGAAGAATAAAAGAGTCTGAGGTATAGACACTGCCCTGGTGACACCTTCTCAGAACATT
GTTGGGGGACAGGGGAGGCAGGCGCAAGTAGGGGATAGAATCTGACCCTGACATGCAGCTATCACCTGGCAGAGAGACTCGTCAAAGCAA
ATTATAACGACCAGTACTATTTTTTTTTGGAATTGAAAACCCAAGAAGCCCTAAAATAAGAACAGTGAGATCAAAGGCTGGTTTCTAAAA
CAATGCAGAAAATAGAACCATGTTGGAATTCCTAAATTCTAGCTTTCAAATACTACTGTTTCCAACAGTGAATCCTTGACAGAGACTGAA
TGCAGATGGAATTTTGAAACATTTTCAGTAGCTACCTCCTCTCCTGAAATTCCTATAAGTGGCAGAGGAAAATCCAAATCCTTTAATATA
ACATGTCCATCTCATGACTCCTGCTTACACACATTTGTGTTGATTTGCTTCATTTCTGGAGGATGGGAATTTGCAGAGCTGGTGACATTT
CCTTCATTAGACACCAGAAATTCACCAGAGAGAGACAGATCTGTGCCTTCTCTTTTTAGGATCTGGTTATTGATACTTTAATAAATGTGG
TGTAAAGAAAATCCATGGCTACAGTCTGTATAGAAAATGTGAATTTTTTAAATAAGATTGTGTTCTTAATGTAAAAAATAAAAGTTTATT

>In-frame_ENST00000282096_ENST00000328457_TCGA-GN-A8LN-01A_PDE3B_chr11_14889304_+_PLCXD3_chr5_41313872_length(amino acids)=1051AA_start in transcript=353_stop in transcript=3508
MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELRPPPASPQQPRRCSPFCRARLSLGALAAFVL
ALLLGAEPESWAAGAAWLRTLLSVCSHSLSPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGD
AGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSLPSALRPLLSGLVGGAGCLLALGLDHFFQIR
EAPLHPRLSSAAEEKVPVIRPRRRSSCVSLGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEAR
NMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGTSGLLPV
EQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDT
ADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEETEKKDS
RKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQF
MNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALE
LMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFD
FLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQES

--------------------------------------------------------------
>In-frame_ENST00000455098_ENST00000377801_TCGA-GN-A8LN-01A_PDE3B_chr11_14889304_+_PLCXD3_chr5_41313872_length(transcript)=10048nt_BP=3231nt
GAGGCGGCAGCTAAACTGGTCCTGGAGAGAAGCCCCTTCCGCCCCTCTCCTCAGCCAGCATGTCCCGGACTCCGCCGCTCCTCAGTCCGC
GCGGTGGGGACCCCGGGCCGTGGCGGCCGGCGCAGCCCTGACGGGTTGCGAACCAGGGGGCGCCCCGAACGCGGGGGTTGGGGTCTGGGA
GCGCGAGCGGCCGCTACGGTACGAGCGGGGTGTGCTGAGTCCCGTGGCCACCCCCGGCCCCAGCCATGAGGAGGGACGAGCGAGACGCCA
AAGCCATGCGGTCCCTGCAGCCGCCGGATGGGGCCGGCTCGCCCCCCGAGAGTCTGAGGAACGGCTACGTGAAGAGCTGCGTGAGCCCCT
TGCGGCAGGACCCTCCGCGCGGCTTCTTCTTCCACCTCTGCCGCTTCTGCAACGTGGAGCTGCGGCCGCCGCCGGCCTCTCCCCAGCAGC
CGCGGCGCTGCTCCCCCTTCTGCCGGGCGCGCCTCTCGCTGGGCGCCCTGGCTGCCTTTGTCCTCGCCCTGCTGCTGGGCGCGGAACCCG
AGAGCTGGGCTGCCGGGGCCGCCTGGCTGCGGACGCTGCTGAGCGTGTGTTCGCACAGCTTGAGCCCCCTCTTCAGCATCGCCTGTGCCT
TCTTCTTCCTCACCTGCTTCCTCACCCGGACCAAGCGGGGACCCGGCCCGGGCCGGAGCTGCGGCTCCTGGTGGCTGCTGGCGCTGCCCG
CCTGCTGTTACCTGGGGGACTTCTTGGTGTGGCAGTGGTGGTCTTGGCCTTGGGGGGATGGCGACGCAGGGTCCGCGGCCCCGCACACGC
CCCCGGAGGCGGCAGCGGGCAGGTTGCTGCTGGTGCTGAGCTGCGTAGGGCTGCTGCTGACGCTCGCGCACCCGCTGCGGCTCCGGCACT
GCGTTCTGGTGCTGCTCCTGGCCAGCTTCGTCTGGTGGGTCTCCTTCACCAGCCTCGGGTCGCTGCCCTCCGCCCTCAGGCCGCTGCTCT
CCGGCCTGGTGGGGGGCGCTGGCTGCCTGCTGGCCCTGGGGTTGGATCACTTCTTTCAAATCAGGGAAGCGCCTCTTCATCCTCGACTGT
CCAGTGCCGCCGAAGAAAAAGTGCCTGTGATCCGACCCCGGAGGAGGTCCAGCTGCGTGTCGTTAGGAGAAACTGCAGCCAGTTACTATG
GCAGTTGCAAAATATTCAGGAGACCGTCGTTGCCTTGTATTTCCAGAGAACAGATGATTCTTTGGGATTGGGACTTAAAACAATGGTATA
AGCCTCATTATCAAAATTCTGGAGGTGGAAATGGAGTTGATCTTTCAGTGCTAAATGAGGCTCGCAATATGGTGTCAGATCTTCTGACTG
ATCCAAGCCTTCCACCACAAGGACTAAATAGGAATAGTTTGCCAACTCCACAGCTGAGGAGAAGCTCAGGAACTTCAGGATTGCTACCTG
TTGAACAGTCTTCAAGGTGGGATCGTAATAATGGCAAAAGACCTCACCAAGAATTTGGCATTTCAAGTCAAGGATGCTATCTAAATGGGC
CTTTTAATTCAAATCTACTGACTATCCCGAAGCAAAGGTCATCTTCTGTATCACTGACTCACCATGTAGGTCTCAGAAGAGCTGGTGTTT
TGTCCAGTCTGAGTCCTGTGAATTCTTCCAACCATGGACCAGTGTCTACTGGCTCTCTAACTAATCGATCACCCATAGAATTTCCTGATA
CTGCTGATTTTCTTAATAAGCCAAGCGTTATCTTGCAGAGATCTCTGGGCAATGCACCTAATACTCCAGATTTTTATCAGCAACTTAGAA
ATTCTGATAGCAATCTGTGTAACAGCTGTGGACATCAAATGCTGAAATATGTTTCAACATCTGAATCAGATGGTACAGATTGCTGCAGTG
GAAAATCAGGTGAAGAAGAAAACATTTTCTCGAAAGAATCATTCAAACTTATGGAAACTCAACAAGAAGAGGAAACAGAGAAGAAAGACA
GCAGAAAATTATTTCAGGAAGGTGATAAGTGGCTAACAGAAGAGGCACAGAGTGAACAGCAAACAAATATTGAACAGGAAGTATCACTGG
ACCTGATTTTAGTAGAAGAGTATGACTCATTAATAGAAAAGATGAGCAACTGGAATTTTCCAATTTTTGAACTTGTAGAAAAGATGGGAG
AGAAATCAGGAAGGATTCTCAGTCAGGTTATGTATACCTTATTTCAAGACACTGGTTTATTGGAAATATTTAAAATTCCCACTCAACAAT
TTATGAACTATTTTCGTGCATTAGAAAATGGCTATCGAGACATTCCTTATCACAATCGTATACATGCCACAGATGTGCTACATGCAGTTT
GGTATCTGACAACACGGCCAGTTCCTGGCTTACAGCAGATCCACAATGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATTA
ACCATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCTGCATTAG
AATTGATGGCTCTATACGTGGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCTC
AGGCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAATACAACT
TCCTTCTTCATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTTG
ATTTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTGGTATGCC
AGGTGTGCATCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTTT
ATGAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTCCAAGAAT
CTTTTATCACCCACATAGTGGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGATA
ATGATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAGCTCTTCC
TGCCATGATGCAGTGGGTCCGCACGCAGAAGCCAGGAGAGAGTGGCATCAATATTGTCACTGCCGATTTTGTAGAACTTGGTGACTTTAT
CAGCACTGTCATAAAGCTCAACTATGTCTTTGATGAAGGAGAAGCCAACACTTGATAGCACTACTTGGAGTTTCCATGAATAAGATGGAG
AAAGCTCATTGTATTAGGGCATACTATCTGTAAACACTCTGATCTTCCTATTCCACTGAGTCTCTGAAGGGAATAGGGCTGGTAGTGGGT
GGGAAAAGGGGAAAAACTGTTTCTTCAGTGATTACAATCATACTCTTCATTACTATAAATATTTCATTTCCCATTTGATGAGCAAAATCT
ACTTCTAGTGTTAGGAATAAAAAAAAAAGACCAGTAACTTTGTTTTTCAAAATTAGTCTTTGTAACATAGAATTCATGAGTGTTTACTTG
ATTAGGTTCTCTATTTCCAGCCTATGACTCCTACGCTGTCTATACCCTGCAACCTTTCTGCTCCCTCTCTTGCTCGCTCTTTTTAATCAG
ATGCTGTATGGGAATCAAAACAATTGAATGCCCAACATTTTGTGTATTACATTGTTGTCTTAAAACTTACTAGTTTTGTGGGACTTGTTA
TAATGCTCTATAGTCATCCACAGTTGGGCAATCATAGCTAATTTTTGGTCATAGAAAATCTGCATCAAATCAGTTTCCATGCATCAGTAA
TATTGAAGGTCATAATCAGTGATTTTTGTTATATGAAAATAATAGTGTTTCACAGTATTTCTATTTAAGGCAGCTATAAATATAGGAGAA
AAATGTTTTTGGAGAGCTGTGAATGCCAATTTCAGAGGGAAAAATGGTTGAGGGGTGAAAGAGATGTATGGCATTTTAATTTGGCAATCT
CTTAAATAATATTGCCCTGCAAGTACCCAGTAAATGGTAAGGTACAAGTGTGTTAAAATTGAAAACTCTGAAAATAACTCTTTAAAAAGC
CCTCTTAATGATGCTCTTGATGAAAGAAAAAGACAGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAAGGA
AGAAAGGAAGGGAGGGAGGAAGGGAGGGAAGAAGGGAGGGAAGGACAGAAGGAAGGACGGGAGGAAGGAAGGAAGGGAGGAAGGAAGGAA
GGAAGAGAGGGAGGGAGGGAGGAAGAGAGGGAGGGAGGGAGGAAGAGAGGAAGGAAGAAGAAAAAGACTGCAAGCTTTCCTGCCAATTTG
GGATTTTCAAATATTTAATTCTAAATTCCAGATTTTAAGGAAGATTTTTCAAGAAACTGCAAGTTTTTGACTTGAAGGAAAGAAAGAGGA
AGGCTGGTAGAAGCAGTTAGAGCAATGTGTTTGAAATTATGTCCATGAAATCACAGGGATCTCTGAAATATCTTTAGGAAACTTGAAATT
TATGAGGTCTGAATGGACTTGTTTAAAATTGGCTCTGACTCCTCACTTCTGAGTTTCATCCTATCCGAGGGATGAGATTAAGGCAGAGGC
AAAAGTTTCACACAAAGTTTCTGCAACCTAACGTTTAATAGTCCGGGTCTACAGGGAAGAACAATGACACAGCTTGAGCGTTACTTCCTC
CTTCGTGTCATTGTGATATTTGACAACTCTAAAAAATAAAAAAAAAAAACTTAGAGCACAATAATCCTTGCCTATGTACTTCACAGGAAT
ATTGTGAGGTGTTTATAAAATTATAAAATTTGATGAAATTCTTACAATTATTAATTATTTTATTTTCATGTTTAGAAATAATCACACCCC
AATAGTTTCCTAGGATAATACAGTCCATGCAAAGTAGGGTCATAGAGAAATAAAAGCATGCCCTCAGCTTTTAATGAACTTAAATGTAGC
ACATATGGCTTAATCTCTTAGACTTAGATAAGGGAGTTCAATTCAAAACCATATATGTCAAGACCACAAATAATCAAGAGTTGATTTCAA
GATTATAAATACTCATGATCAGAAAATAGTACTTATTAGCAATTAAAGGGAGGAAAAGAAATTGTTTATACTGAAGAGAATGTTTATGAG
GAGTGTGTATGTACCTGTGGTATACCAAATAGCATACATGTACACACAAAAATGTGTGTATACATTTGGGTTGTGTGTATACATCTTGCC
ATATACAATATACAAACATATGCCCATTCCTGTGATAGCATACAAATTCAAACATACAGAAACACACACAGATATGGACACAGTACAATT
CTTCTTTTCAAATGAAGACATTGATAATATTAAATAATTTAATTTTAAGACTGAAACCCTTAATATTGTGTGAAAAAGAGTAATAAAACC
TTTGAAAGTAGAGTAGATGATCACATCAAAGTATTTTTGTAAAAGAATTCTAGTGTAGGACTTAATTATTTTTAAAATATATTTCTTCTC
TTCTTTCCATTTTCCCTTCCCTTGTAGTTTTATTATCTTTCTGTCTTTTACACCTGCTCTTTATGTGAAAATGTATATGAATCCTTTTAA
AATGATTAGGATTATTGAAATGTATGTCCCGTAAATTTGGTTTTTGGGCAGACTTTCTCTCTAACTGGCTATTCATTCATCCTTCAGGAG
GATCTTAGCCAAGAATATTTGCAATGACACATGAATTTAATTTTATAAATATAATGGAAAACAGATTTTTCATCATATCATGAATAAAAT
ATAGAGGTAACTATGTTGTATTTTCTTGAACCTAGATACTTTCTCATAGTGTTTGCTTAGAATTAACTTTGTCCTATTTGTCAACTGGGT
TCTGGAAAAAAACAAACATGATGAAGCTTTTGAATAATTGTGCAGTTTTTTAACTAGGGAAAGCTTTGTACTGCTGCTAATGATATGCAC
CCAGAAACCTTGTTAGACAAAAGGCAGTTTCAAGCCAATGCTATGGTTTCCATGTGGACATACAGTGCCTATGTAGCAGGCACTTAGAGT
AAATGGACTTGCCTTAATTTATAAAGGAGGGAAGAGGTAGAAGGGAACCATGGGTCCTCCAGCTAGAGGGGGAGTTTACTAAAAGGGAGT
CCTTGGAAAGGGGAATGGAGAGAAGGTGCCTTTGACTGTCTTCTATCCATTAGTTCTGCCCTGGAGCACACTGGGGAAGCAGGCTGCGGG
CCTTCCAAAAGTAAAAAATGGTGATATGCAATCGAAGCTTATCCTTAGCCTATGCACATTTGTCTCAGCTGGGCATTGTCTTTTCAGAGA
GCTTGTAGCACAAGGGCTACACATGGGCGCCAAGATGGTGGTAGATACACCTTGGTGCACTTTTTGTTTTACTTGTTTCTTAAGACTATT
TCACAAGTCCTGTGAGGCAAAAAAACAAAACAAAACAAAACAACCAAACAAATACAATCTAACTTTTACCCAATCTACAGCAGGAAATCA
AAGGAGTGGGTGGAATGAGAGAAAATATGCAAAGAGATCATTTTTAAGTTTGATTTCCTGTCTGTAATTTTCAAGGACTAATATAGCAAA
TTTTTCTTCTGCCATTATCATTTATGTCTCCCTATTTACCACACAATAATGTAAATGCAGAGAATGAGGAGGCATCTTTTAAAAGCCTTA
GGATATTCTATATGATGACCTCAATATTGACTTTCAGCCATACTGGGAAAACTTACTTTTCATGGAGTGCCACCTAACAGTGAATGTATT
AGAGTATAAAATGTTTGCCATGTATACACCTGTATGTGCACATACACACATTACACACACACACAGAATGCACATTTCACACACATATAC
TTATTATTCAAGTTGAAACTGCACTCTAATCAATCTGAGTCTATTGCTGTTTCAACTCTTAAAATCAATATCTCCTACATTAGTAGATAT
AAACATAATTCAAATATTTAAATATTTAAGAGGAGAAAAGTAACTAGAAAACCAATGAAAAGTGAGGCCATCAGAAATAGAAAATGCCTG
GCACGAACAGTCTATCTAAATTCTCAATTTCACTTCAAATTAGAGAATCCATAATGGACTAGAATATAAATTACAAACACATACACACAT
CTTCACTTAAAGTTGTTTTAAGTTCTTTGAAGTTCTGACATGTTTTTAGCCAGGGTTATTTGTTCAGGTTCTTCCTTGTTAGGATTCCAG
ACTGGAAAGTTGGAAGTCTCAGGAAATGCATGTTTCCATGAGTTTTTTAGTTTCACAGTTTTACAGATCCAACGACACAATCTTTTAATC
TTTGGTCACTCAACCAAACAGGAGTTCCGTAGGCAGAGTGCTCACTTTGAATTGCTAATAGAAAATAATGCACAGTGTCCTCAGGATATG
CTAAACAAGGTTTTTAAGAGCATTTTATTTTACAGCACTTTAGTCTTTTCAGCTAGATTTCAGTGACACTATGGTGTAAATGCTATATCT
GCCATAACTTATTGGTGGCTCCTGTGTTACATACAGTTTTAAATAATGCTCTAAATTGTTTGTTTTCCCAATGATAATGATAAAGTGTTC
TGTAGAATTTGTAAAACATGTCAATTGAATCTGTTGAAAATTGTGTAATTGTTATTTCAATTGTGATACTATTTTGTAGGTAATAGTTTT
AAACGTATATTTGTATGAGTCAAAAGTATGTGCTTGTATGTGGTATGTGTGTGTAAGTATATAATATCTTATCAAAAATCAAACTTATCC
TAAAGAAAAAGGGCACATTGTGACCAGCCTTAATTTATTAACACTTTTTTGTTGTTTTTGCAATTTGGATTTAAAATTGAAACAGAAATT
AAGTTTTTGTTAAAAATGGTGTCTTTTAATTTTGTGAGGAATGGGCTTTAGAACCTATCTGAGTTCCCACAAGCAAACTGTCCACCTTGT
GAGGTACCCCATTGCTTTTCGTAATAATCAAACATCAATTCATATATTAACTTCATTTTCATACAGACTAATTTGTTTTCATCAACAATA
GAACCAGTACACCTTTAAAGTTGACCTTCCCAACATGGCACCCATTTTTCTTTAATGATAAATTTTCCATGAAAAATTGTTTCTCCAAAC
CATTACTTTTTAAAATTCAATCTTCCCAAGTAAGATGAACTGCCTTGGTGTTAGGAGAGCTTTTAAAGGCCCATCCATACTAGGTGGTTC
CAACATGGTTCTCTTCTCGAGAAAACAAGCATGCAACCCACACACTTTTCTGGTCTGCCCCACGTGTAGAATTAGTCTAGCAATAGAAAA
CTCATGACTGACAAGGATCTACACATGTGGTCATGCTTGAAGCAAAAATTCTGTGACCTTCTTTGGGCTTGGATCTGATTACAGAATATT
AATTAACTTTCTTATTTCCTTTCTTTCTCCATCCTTAGTTATTCCTTTTCAATATTTAGAGTTGCCAGGTAAAATACAGGATATCCAGTG
AAATTTAAATTTCAGATAAACAGTATTTCTTTAGCATATTTCTCATATATTTAATCAGACATACTTTCACTTTAAAAAAAGTTTATCTGA
AATTCAAATGTAACTGGGTATGTCCTATATATTTTTTCCTAAATCTCACAATTCTATCCACACTGCCTTTCTATCTTTTTCAGCTGGGCT
ATCTATAAGGGGCGAGATCTACCTCCCTCCATACCCTTGTGTTCAGACACCTTATGAATATCTGCAGTCATAATGTCCTTCAAGAAAGAA
AACATTGGTCAGCTCTAGGTCCTGCAAATGCTTTTTGAAGGACGAACTCAAATACAGATGGGATAATCAAGTAAATATCTTCATAGGATC
AATGCCACCATGTTCAACACTTCCCTTTGCCAGCCTGTTGTGAGGTCCAAGTTTCCCCATTAATCCCTTATATAGCATTTCCCAGTAACT
GGGACAACCAAAAACACACCGACATATTAGAAATGCTCCTGAAAAGTGGCAACACCGCCTAACTCAGTACCAGGACCTCTTTTAAATTCA
ATTTCTTTTTTCTTTCAGAGAGATAACAAACGAATTCATTATTTCCCCCATTCACATCTTACCACAAATTATTTTTATCAGGTTAAAACT
GGTCATCTACGGAATTGTAGAAAGGTGACATAGGAACTGTCTTCACTGCTGGAAGAATAAAAGAGTCTGAGGTATAGACACTGCCCTGGT
GACACCTTCTCAGAACATTGTTGGGGGACAGGGGAGGCAGGCGCAAGTAGGGGATAGAATCTGACCCTGACATGCAGCTATCACCTGGCA
GAGAGACTCGTCAAAGCAAATTATAACGACCAGTACTATTTTTTTTTGGAATTGAAAACCCAAGAAGCCCTAAAATAAGAACAGTGAGAT
CAAAGGCTGGTTTCTAAAACAATGCAGAAAATAGAACCATGTTGGAATTCCTAAATTCTAGCTTTCAAATACTACTGTTTCCAACAGTGA
ATCCTTGACAGAGACTGAATGCAGATGGAATTTTGAAACATTTTCAGTAGCTACCTCCTCTCCTGAAATTCCTATAAGTGGCAGAGGAAA
ATCCAAATCCTTTAATATAACATGTCCATCTCATGACTCCTGCTTACACACATTTGTGTTGATTTGCTTCATTTCTGGAGGATGGGAATT
TGCAGAGCTGGTGACATTTCCTTCATTAGACACCAGAAATTCACCAGAGAGAGACAGATCTGTGCCTTCTCTTTTTAGGATCTGGTTATT
GATACTTTAATAAATGTGGTGTAAAGAAAATCCATGGCTACAGTCTGTATAGAAAATGTGAATTTTTTAAATAAGATTGTGTTCTTAATG

>In-frame_ENST00000455098_ENST00000377801_TCGA-GN-A8LN-01A_PDE3B_chr11_14889304_+_PLCXD3_chr5_41313872_length(amino acids)=1000AA_start in transcript=245_stop in transcript=3247
MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELRPPPASPQQPRRCSPFCRARLSLGALAAFVL
ALLLGAEPESWAAGAAWLRTLLSVCSHSLSPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGD
AGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSLPSALRPLLSGLVGGAGCLLALGLDHFFQIR
EAPLHPRLSSAAEEKVPVIRPRRRSSCVSLGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEAR
NMVSDLLTDPSLPPQGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHH
VGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSE
SDGTDCCSGKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPI
FELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGN
ETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNL
YLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKW
TEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEME

--------------------------------------------------------------
>In-frame_ENST00000455098_ENST00000328457_TCGA-GN-A8LN-01A_PDE3B_chr11_14889304_+_PLCXD3_chr5_41313872_length(transcript)=9855nt_BP=3231nt
GAGGCGGCAGCTAAACTGGTCCTGGAGAGAAGCCCCTTCCGCCCCTCTCCTCAGCCAGCATGTCCCGGACTCCGCCGCTCCTCAGTCCGC
GCGGTGGGGACCCCGGGCCGTGGCGGCCGGCGCAGCCCTGACGGGTTGCGAACCAGGGGGCGCCCCGAACGCGGGGGTTGGGGTCTGGGA
GCGCGAGCGGCCGCTACGGTACGAGCGGGGTGTGCTGAGTCCCGTGGCCACCCCCGGCCCCAGCCATGAGGAGGGACGAGCGAGACGCCA
AAGCCATGCGGTCCCTGCAGCCGCCGGATGGGGCCGGCTCGCCCCCCGAGAGTCTGAGGAACGGCTACGTGAAGAGCTGCGTGAGCCCCT
TGCGGCAGGACCCTCCGCGCGGCTTCTTCTTCCACCTCTGCCGCTTCTGCAACGTGGAGCTGCGGCCGCCGCCGGCCTCTCCCCAGCAGC
CGCGGCGCTGCTCCCCCTTCTGCCGGGCGCGCCTCTCGCTGGGCGCCCTGGCTGCCTTTGTCCTCGCCCTGCTGCTGGGCGCGGAACCCG
AGAGCTGGGCTGCCGGGGCCGCCTGGCTGCGGACGCTGCTGAGCGTGTGTTCGCACAGCTTGAGCCCCCTCTTCAGCATCGCCTGTGCCT
TCTTCTTCCTCACCTGCTTCCTCACCCGGACCAAGCGGGGACCCGGCCCGGGCCGGAGCTGCGGCTCCTGGTGGCTGCTGGCGCTGCCCG
CCTGCTGTTACCTGGGGGACTTCTTGGTGTGGCAGTGGTGGTCTTGGCCTTGGGGGGATGGCGACGCAGGGTCCGCGGCCCCGCACACGC
CCCCGGAGGCGGCAGCGGGCAGGTTGCTGCTGGTGCTGAGCTGCGTAGGGCTGCTGCTGACGCTCGCGCACCCGCTGCGGCTCCGGCACT
GCGTTCTGGTGCTGCTCCTGGCCAGCTTCGTCTGGTGGGTCTCCTTCACCAGCCTCGGGTCGCTGCCCTCCGCCCTCAGGCCGCTGCTCT
CCGGCCTGGTGGGGGGCGCTGGCTGCCTGCTGGCCCTGGGGTTGGATCACTTCTTTCAAATCAGGGAAGCGCCTCTTCATCCTCGACTGT
CCAGTGCCGCCGAAGAAAAAGTGCCTGTGATCCGACCCCGGAGGAGGTCCAGCTGCGTGTCGTTAGGAGAAACTGCAGCCAGTTACTATG
GCAGTTGCAAAATATTCAGGAGACCGTCGTTGCCTTGTATTTCCAGAGAACAGATGATTCTTTGGGATTGGGACTTAAAACAATGGTATA
AGCCTCATTATCAAAATTCTGGAGGTGGAAATGGAGTTGATCTTTCAGTGCTAAATGAGGCTCGCAATATGGTGTCAGATCTTCTGACTG
ATCCAAGCCTTCCACCACAAGGACTAAATAGGAATAGTTTGCCAACTCCACAGCTGAGGAGAAGCTCAGGAACTTCAGGATTGCTACCTG
TTGAACAGTCTTCAAGGTGGGATCGTAATAATGGCAAAAGACCTCACCAAGAATTTGGCATTTCAAGTCAAGGATGCTATCTAAATGGGC
CTTTTAATTCAAATCTACTGACTATCCCGAAGCAAAGGTCATCTTCTGTATCACTGACTCACCATGTAGGTCTCAGAAGAGCTGGTGTTT
TGTCCAGTCTGAGTCCTGTGAATTCTTCCAACCATGGACCAGTGTCTACTGGCTCTCTAACTAATCGATCACCCATAGAATTTCCTGATA
CTGCTGATTTTCTTAATAAGCCAAGCGTTATCTTGCAGAGATCTCTGGGCAATGCACCTAATACTCCAGATTTTTATCAGCAACTTAGAA
ATTCTGATAGCAATCTGTGTAACAGCTGTGGACATCAAATGCTGAAATATGTTTCAACATCTGAATCAGATGGTACAGATTGCTGCAGTG
GAAAATCAGGTGAAGAAGAAAACATTTTCTCGAAAGAATCATTCAAACTTATGGAAACTCAACAAGAAGAGGAAACAGAGAAGAAAGACA
GCAGAAAATTATTTCAGGAAGGTGATAAGTGGCTAACAGAAGAGGCACAGAGTGAACAGCAAACAAATATTGAACAGGAAGTATCACTGG
ACCTGATTTTAGTAGAAGAGTATGACTCATTAATAGAAAAGATGAGCAACTGGAATTTTCCAATTTTTGAACTTGTAGAAAAGATGGGAG
AGAAATCAGGAAGGATTCTCAGTCAGGTTATGTATACCTTATTTCAAGACACTGGTTTATTGGAAATATTTAAAATTCCCACTCAACAAT
TTATGAACTATTTTCGTGCATTAGAAAATGGCTATCGAGACATTCCTTATCACAATCGTATACATGCCACAGATGTGCTACATGCAGTTT
GGTATCTGACAACACGGCCAGTTCCTGGCTTACAGCAGATCCACAATGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATTA
ACCATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGCTGCCTGTCTTCAAACATTCCTGCATTAG
AATTGATGGCTCTATACGTGGCAGCTGCCATGCATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCTC
AGGCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAATCTATATCTTTCTCGCCCAGAATACAACT
TCCTTCTTCATCTTGATCATGTGGAATTCAAGCGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTTG
ATTTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGTAATGAAAATGATCGCCTCTTGGTATGCC
AGGTGTGCATCAAACTGGCAGATATAAATGGCCCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTTT
ATGAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCTTCTCCTCAACTAGCAAAACTCCAAGAAT
CTTTTATCACCCACATAGTGGGTCCCCTGTGTAACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGATA
ATGATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATGGAAAACAATCTAAATCCAAAGCTCTTCC
TGCCATGATGCAGTGGGTCCGCACGCAGAAGCCAGGAGAGAGTGGCATCAATATTGTCACTGCCGATTTTGTAGAACTTGGTGACTTTAT
CAGCACTGTCATAAAGCTCAACTATGTCTTTGATGAAGGAGAAGCCAACACTTGATAGCACTACTTGGAGTTTCCATGAATAAGATGGAG
AAAGCTCATTGTATTAGGGCATACTATCTGTAAACACTCTGATCTTCCTATTCCACTGAGTCTCTGAAGGGAATAGGGCTGGTAGTGGGT
GGGAAAAGGGGAAAAACTGTTTCTTCAGTGATTACAATCATACTCTTCATTACTATAAATATTTCATTTCCCATTTGATGAGCAAAATCT
ACTTCTAGTGTTAGGAATAAAAAAAAAAGACCAGTAACTTTGTTTTTCAAAATTAGTCTTTGTAACATAGAATTCATGAGTGTTTACTTG
ATTAGGTTCTCTATTTCCAGCCTATGACTCCTACGCTGTCTATACCCTGCAACCTTTCTGCTCCCTCTCTTGCTCGCTCTTTTTAATCAG
ATGCTGTATGGGAATCAAAACAATTGAATGCCCAACATTTTGTGTATTACATTGTTGTCTTAAAACTTACTAGTTTTGTGGGACTTGTTA
TAATGCTCTATAGTCATCCACAGTTGGGCAATCATAGCTAATTTTTGGTCATAGAAAATCTGCATCAAATCAGTTTCCATGCATCAGTAA
TATTGAAGGTCATAATCAGTGATTTTTGTTATATGAAAATAATAGTGTTTCACAGTATTTCTATTTAAGGCAGCTATAAATATAGGAGAA
AAATGTTTTTGGAGAGCTGTGAATGCCAATTTCAGAGGGAAAAATGGTTGAGGGGTGAAAGAGATGTATGGCATTTTAATTTGGCAATCT
CTTAAATAATATTGCCCTGCAAGTACCCAGTAAATGGTAAGGTACAAGTGTGTTAAAATTGAAAACTCTGAAAATAACTCTTTAAAAAGC
CCTCTTAATGATGCTCTTGATGAAAGAAAAAGACAGAAGGAAGGAAGAAGAAAAAGACTGCAAGCTTTCCTGCCAATTTGGGATTTTCAA
ATATTTAATTCTAAATTCCAGATTTTAAGGAAGATTTTTCAAGAAACTGCAAGTTTTTGACTTGAAGGAAAGAAAGAGGAAGGCTGGTAG
AAGCAGTTAGAGCAATGTGTTTGAAATTATGTCCATGAAATCACAGGGATCTCTGAAATATCTTTAGGAAACTTGAAATTTATGAGGTCT
GAATGGACTTGTTTAAAATTGGCTCTGACTCCTCACTTCTGAGTTTCATCCTATCCGAGGGATGAGATTAAGGCAGAGGCAAAAGTTTCA
CACAAAGTTTCTGCAACCTAACGTTTAATAGTCCGGGTCTACAGGGAAGAACAATGACACAGCTTGAGCGTTACTTCCTCCTTCGTGTCA
TTGTGATATTTGACAACTCTAAAAAATAAAAAAAAAAAACTTAGAGCACAATAATCCTTGCCTATGTACTTCACAGGAATATTGTGAGGT
GTTTATAAAATTATAAAATTTGATGAAATTCTTACAATTATTAATTATTTTATTTTCATGTTTAGAAATAATCACACCCCAATAGTTTCC
TAGGATAATACAGTCCATGCAAAGTAGGGTCATAGAGAAATAAAAGCATGCCCTCAGCTTTTAATGAACTTAAATGTAGCACATATGGCT
TAATCTCTTAGACTTAGATAAGGGAGTTCAATTCAAAACCATATATGTCAAGACCACAAATAATCAAGAGTTGATTTCAAGATTATAAAT
ACTCATGATCAGAAAATAGTACTTATTAGCAATTAAAGGGAGGAAAAGAAATTGTTTATACTGAAGAGAATGTTTATGAGGAGTGTGTAT
GTACCTGTGGTATACCAAATAGCATACATGTACACACAAAAATGTGTGTATACATTTGGGTTGTGTGTATACATCTTGCCATATACAATA
TACAAACATATGCCCATTCCTGTGATAGCATACAAATTCAAACATACAGAAACACACACAGATATGGACACAGTACAATTCTTCTTTTCA
AATGAAGACATTGATAATATTAAATAATTTAATTTTAAGACTGAAACCCTTAATATTGTGTGAAAAAGAGTAATAAAACCTTTGAAAGTA
GAGTAGATGATCACATCAAAGTATTTTTGTAAAAGAATTCTAGTGTAGGACTTAATTATTTTTAAAATATATTTCTTCTCTTCTTTCCAT
TTTCCCTTCCCTTGTAGTTTTATTATCTTTCTGTCTTTTACACCTGCTCTTTATGTGAAAATGTATATGAATCCTTTTAAAATGATTAGG
ATTATTGAAATGTATGTCCCGTAAATTTGGTTTTTGGGCAGACTTTCTCTCTAACTGGCTATTCATTCATCCTTCAGGAGGATCTTAGCC
AAGAATATTTGCAATGACACATGAATTTAATTTTATAAATATAATGGAAAACAGATTTTTCATCATATCATGAATAAAATATAGAGGTAA
CTATGTTGTATTTTCTTGAACCTAGATACTTTCTCATAGTGTTTGCTTAGAATTAACTTTGTCCTATTTGTCAACTGGGTTCTGGAAAAA
AACAAACATGATGAAGCTTTTGAATAATTGTGCAGTTTTTTAACTAGGGAAAGCTTTGTACTGCTGCTAATGATATGCACCCAGAAACCT
TGTTAGACAAAAGGCAGTTTCAAGCCAATGCTATGGTTTCCATGTGGACATACAGTGCCTATGTAGCAGGCACTTAGAGTAAATGGACTT
GCCTTAATTTATAAAGGAGGGAAGAGGTAGAAGGGAACCATGGGTCCTCCAGCTAGAGGGGGAGTTTACTAAAAGGGAGTCCTTGGAAAG
GGGAATGGAGAGAAGGTGCCTTTGACTGTCTTCTATCCATTAGTTCTGCCCTGGAGCACACTGGGGAAGCAGGCTGCGGGCCTTCCAAAA
GTAAAAAATGGTGATATGCAATCGAAGCTTATCCTTAGCCTATGCACATTTGTCTCAGCTGGGCATTGTCTTTTCAGAGAGCTTGTAGCA
CAAGGGCTACACATGGGCGCCAAGATGGTGGTAGATACACCTTGGTGCACTTTTTGTTTTACTTGTTTCTTAAGACTATTTCACAAGTCC
TGTGAGGCAAAAAAACAAAACAAAACAAAACAACCAAACAAATACAATCTAACTTTTACCCAATCTACAGCAGGAAATCAAAGGAGTGGG
TGGAATGAGAGAAAATATGCAAAGAGATCATTTTTAAGTTTGATTTCCTGTCTGTAATTTTCAAGGACTAATATAGCAAATTTTTCTTCT
GCCATTATCATTTATGTCTCCCTATTTACCACACAATAATGTAAATGCAGAGAATGAGGAGGCATCTTTTAAAAGCCTTAGGATATTCTA
TATGATGACCTCAATATTGACTTTCAGCCATACTGGGAAAACTTACTTTTCATGGAGTGCCACCTAACAGTGAATGTATTAGAGTATAAA
ATGTTTGCCATGTATACACCTGTATGTGCACATACACACATTACACACACACACAGAATGCACATTTCACACACATATACTTATTATTCA
AGTTGAAACTGCACTCTAATCAATCTGAGTCTATTGCTGTTTCAACTCTTAAAATCAATATCTCCTACATTAGTAGATATAAACATAATT
CAAATATTTAAATATTTAAGAGGAGAAAAGTAACTAGAAAACCAATGAAAAGTGAGGCCATCAGAAATAGAAAATGCCTGGCACGAACAG
TCTATCTAAATTCTCAATTTCACTTCAAATTAGAGAATCCATAATGGACTAGAATATAAATTACAAACACATACACACATCTTCACTTAA
AGTTGTTTTAAGTTCTTTGAAGTTCTGACATGTTTTTAGCCAGGGTTATTTGTTCAGGTTCTTCCTTGTTAGGATTCCAGACTGGAAAGT
TGGAAGTCTCAGGAAATGCATGTTTCCATGAGTTTTTTAGTTTCACAGTTTTACAGATCCAACGACACAATCTTTTAATCTTTGGTCACT
CAACCAAACAGGAGTTCCGTAGGCAGAGTGCTCACTTTGAATTGCTAATAGAAAATAATGCACAGTGTCCTCAGGATATGCTAAACAAGG
TTTTTAAGAGCATTTTATTTTACAGCACTTTAGTCTTTTCAGCTAGATTTCAGTGACACTATGGTGTAAATGCTATATCTGCCATAACTT
ATTGGTGGCTCCTGTGTTACATACAGTTTTAAATAATGCTCTAAATTGTTTGTTTTCCCAATGATAATGATAAAGTGTTCTGTAGAATTT
GTAAAACATGTCAATTGAATCTGTTGAAAATTGTGTAATTGTTATTTCAATTGTGATACTATTTTGTAGGTAATAGTTTTAAACGTATAT
TTGTATGAGTCAAAAGTATGTGCTTGTATGTGGTATGTGTGTGTAAGTATATAATATCTTATCAAAAATCAAACTTATCCTAAAGAAAAA
GGGCACATTGTGACCAGCCTTAATTTATTAACACTTTTTTGTTGTTTTTGCAATTTGGATTTAAAATTGAAACAGAAATTAAGTTTTTGT
TAAAAATGGTGTCTTTTAATTTTGTGAGGAATGGGCTTTAGAACCTATCTGAGTTCCCACAAGCAAACTGTCCACCTTGTGAGGTACCCC
ATTGCTTTTCGTAATAATCAAACATCAATTCATATATTAACTTCATTTTCATACAGACTAATTTGTTTTCATCAACAATAGAACCAGTAC
ACCTTTAAAGTTGACCTTCCCAACATGGCACCCATTTTTCTTTAATGATAAATTTTCCATGAAAAATTGTTTCTCCAAACCATTACTTTT
TAAAATTCAATCTTCCCAAGTAAGATGAACTGCCTTGGTGTTAGGAGAGCTTTTAAAGGCCCATCCATACTAGGTGGTTCCAACATGGTT
CTCTTCTCGAGAAAACAAGCATGCAACCCACACACTTTTCTGGTCTGCCCCACGTGTAGAATTAGTCTAGCAATAGAAAACTCATGACTG
ACAAGGATCTACACATGTGGTCATGCTTGAAGCAAAAATTCTGTGACCTTCTTTGGGCTTGGATCTGATTACAGAATATTAATTAACTTT
CTTATTTCCTTTCTTTCTCCATCCTTAGTTATTCCTTTTCAATATTTAGAGTTGCCAGGTAAAATACAGGATATCCAGTGAAATTTAAAT
TTCAGATAAACAGTATTTCTTTAGCATATTTCTCATATATTTAATCAGACATACTTTCACTTTAAAAAAAGTTTATCTGAAATTCAAATG
TAACTGGGTATGTCCTATATATTTTTTCCTAAATCTCACAATTCTATCCACACTGCCTTTCTATCTTTTTCAGCTGGGCTATCTATAAGG
GGCGAGATCTACCTCCCTCCATACCCTTGTGTTCAGACACCTTATGAATATCTGCAGTCATAATGTCCTTCAAGAAAGAAAACATTGGTC
AGCTCTAGGTCCTGCAAATGCTTTTTGAAGGACGAACTCAAATACAGATGGGATAATCAAGTAAATATCTTCATAGGATCAATGCCACCA
TGTTCAACACTTCCCTTTGCCAGCCTGTTGTGAGGTCCAAGTTTCCCCATTAATCCCTTATATAGCATTTCCCAGTAACTGGGACAACCA
AAAACACACCGACATATTAGAAATGCTCCTGAAAAGTGGCAACACCGCCTAACTCAGTACCAGGACCTCTTTTAAATTCAATTTCTTTTT
TCTTTCAGAGAGATAACAAACGAATTCATTATTTCCCCCATTCACATCTTACCACAAATTATTTTTATCAGGTTAAAACTGGTCATCTAC
GGAATTGTAGAAAGGTGACATAGGAACTGTCTTCACTGCTGGAAGAATAAAAGAGTCTGAGGTATAGACACTGCCCTGGTGACACCTTCT
CAGAACATTGTTGGGGGACAGGGGAGGCAGGCGCAAGTAGGGGATAGAATCTGACCCTGACATGCAGCTATCACCTGGCAGAGAGACTCG
TCAAAGCAAATTATAACGACCAGTACTATTTTTTTTTGGAATTGAAAACCCAAGAAGCCCTAAAATAAGAACAGTGAGATCAAAGGCTGG
TTTCTAAAACAATGCAGAAAATAGAACCATGTTGGAATTCCTAAATTCTAGCTTTCAAATACTACTGTTTCCAACAGTGAATCCTTGACA
GAGACTGAATGCAGATGGAATTTTGAAACATTTTCAGTAGCTACCTCCTCTCCTGAAATTCCTATAAGTGGCAGAGGAAAATCCAAATCC
TTTAATATAACATGTCCATCTCATGACTCCTGCTTACACACATTTGTGTTGATTTGCTTCATTTCTGGAGGATGGGAATTTGCAGAGCTG
GTGACATTTCCTTCATTAGACACCAGAAATTCACCAGAGAGAGACAGATCTGTGCCTTCTCTTTTTAGGATCTGGTTATTGATACTTTAA
TAAATGTGGTGTAAAGAAAATCCATGGCTACAGTCTGTATAGAAAATGTGAATTTTTTAAATAAGATTGTGTTCTTAATGTAAAAAATAA

>In-frame_ENST00000455098_ENST00000328457_TCGA-GN-A8LN-01A_PDE3B_chr11_14889304_+_PLCXD3_chr5_41313872_length(amino acids)=1000AA_start in transcript=245_stop in transcript=3247
MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELRPPPASPQQPRRCSPFCRARLSLGALAAFVL
ALLLGAEPESWAAGAAWLRTLLSVCSHSLSPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGD
AGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSLPSALRPLLSGLVGGAGCLLALGLDHFFQIR
EAPLHPRLSSAAEEKVPVIRPRRRSSCVSLGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEAR
NMVSDLLTDPSLPPQGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHH
VGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSE
SDGTDCCSGKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPI
FELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGN
ETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNL
YLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKW
TEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEME

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Fusion Gene PPI Analysis for PDE3B-PLCXD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgenePDE3Bchr11:14889304chr5:41313872ENST00000282096+1516436_4601046.33333333333331113.0PIK3R6
HgenePDE3Bchr11:14889304chr5:41313872ENST00000282096+15161_251046.33333333333331113.0RAPGEF3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDE3B-PLCXD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDE3B-PLCXD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDE3BC0032460Polycystic Ovary Syndrome1CTD_human
HgenePDE3BC1136382Sclerocystic Ovaries1CTD_human
TgenePLCXD3C0005586Bipolar Disorder1PSYGENET