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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDE4D-CRABP1 (FusionGDB2 ID:63312)

Fusion Gene Summary for PDE4D-CRABP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE4D-CRABP1
Fusion gene ID: 63312
HgeneTgene
Gene symbol

PDE4D

CRABP1

Gene ID

5144

1381

Gene namephosphodiesterase 4Dcellular retinoic acid binding protein 1
SynonymsACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1CRABP|CRABP-I|CRABPI|RBP5
Cytomap

5q11.2-q12.1

15q25.1

Type of geneprotein-codingprotein-coding
DescriptioncAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136cellular retinoic acid-binding protein 1cellular retinoic acid-binding protein I
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000340635, ENST00000360047, 
ENST00000507116, ENST00000502484, 
ENST00000546160, ENST00000502575, 
ENST00000358923, ENST00000503258, 
ENST00000405755, ENST00000317118, 
ENST00000503947, 		ENST00000299529, 
Fusion gene scores* DoF score40 X 32 X 12=153601 X 2 X 1=2
# samples 562
** MAII scorelog2(56/15360*10)=-4.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context

PubMed: PDE4D [Title/Abstract] AND CRABP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDE4D(58334686)-CRABP1(78640269), # samples:3
Anticipated loss of major functional domain due to fusion event.PDE4D-CRABP1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PDE4D-CRABP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PDE4D-CRABP1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PDE4D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CRABP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-86-7713-01APDE4Dchr5

58334686

-CRABP1chr15

78640269

+
ChimerDB4LUADTCGA-86-7713PDE4Dchr5

58334685

-CRABP1chr15

78640268

+
ChimerDB4LUADTCGA-86-7713-01APDE4Dchr5

58334686

-CRABP1chr15

78640269

+
ChimerDB4LUADTCGA-86-7713-01APDE4Dchr5

58334686

-CRABP1chr15

78640269

+
ChimerDB4LUADTCGA-86-7713-01APDE4Dchr5

58334685

-CRABP1chr15

78640268

+


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Fusion Gene ORF analysis for PDE4D-CRABP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000340635ENST00000299529PDE4Dchr5

58334686

-CRABP1chr15

78640269

+
Frame-shiftENST00000360047ENST00000299529PDE4Dchr5

58334686

-CRABP1chr15

78640269

+
Frame-shiftENST00000507116ENST00000299529PDE4Dchr5

58334686

-CRABP1chr15

78640269

+
In-frameENST00000502484ENST00000299529PDE4Dchr5

58334686

-CRABP1chr15

78640269

+
Frame-shiftENST00000546160ENST00000299529PDE4Dchr5

58334686

-CRABP1chr15

78640269

+
intron-3CDSENST00000502575ENST00000299529PDE4Dchr5

58334686

-CRABP1chr15

78640269

+
Frame-shiftENST00000358923ENST00000299529PDE4Dchr5

58334686

-CRABP1chr15

78640269

+
Frame-shiftENST00000503258ENST00000299529PDE4Dchr5

58334686

-CRABP1chr15

78640269

+
Frame-shiftENST00000405755ENST00000299529PDE4Dchr5

58334686

-CRABP1chr15

78640269

+
intron-3CDSENST00000317118ENST00000299529PDE4Dchr5

58334686

-CRABP1chr15

78640269

+
intron-3CDSENST00000503947ENST00000299529PDE4Dchr5

58334686

-CRABP1chr15

78640269

+
Frame-shiftENST00000340635ENST00000299529PDE4Dchr5

58334685

-CRABP1chr15

78640268

+
Frame-shiftENST00000360047ENST00000299529PDE4Dchr5

58334685

-CRABP1chr15

78640268

+
Frame-shiftENST00000507116ENST00000299529PDE4Dchr5

58334685

-CRABP1chr15

78640268

+
In-frameENST00000502484ENST00000299529PDE4Dchr5

58334685

-CRABP1chr15

78640268

+
Frame-shiftENST00000546160ENST00000299529PDE4Dchr5

58334685

-CRABP1chr15

78640268

+
intron-3CDSENST00000502575ENST00000299529PDE4Dchr5

58334685

-CRABP1chr15

78640268

+
Frame-shiftENST00000358923ENST00000299529PDE4Dchr5

58334685

-CRABP1chr15

78640268

+
Frame-shiftENST00000503258ENST00000299529PDE4Dchr5

58334685

-CRABP1chr15

78640268

+
Frame-shiftENST00000405755ENST00000299529PDE4Dchr5

58334685

-CRABP1chr15

78640268

+
intron-3CDSENST00000317118ENST00000299529PDE4Dchr5

58334685

-CRABP1chr15

78640268

+
intron-3CDSENST00000503947ENST00000299529PDE4Dchr5

58334685

-CRABP1chr15

78640268

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000502484PDE4Dchr558334686-ENST00000299529CRABP1chr1578640269+12669622241012262
ENST00000502484PDE4Dchr558334685-ENST00000299529CRABP1chr1578640268+12669622241012262

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000502484ENST00000299529PDE4Dchr558334686-CRABP1chr1578640269+0.0024143850.99758565
ENST00000502484ENST00000299529PDE4Dchr558334685-CRABP1chr1578640268+0.0024143850.99758565

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Fusion Genomic Features for PDE4D-CRABP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PDE4Dchr558334685-CRABP1chr1578640268+1.92E-101
PDE4Dchr558334685-CRABP1chr1578640268+1.92E-101
PDE4Dchr558334685-CRABP1chr1578640268+1.92E-101
PDE4Dchr558334685-CRABP1chr1578640268+1.92E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDE4D-CRABP1


check button Go to

FGviewer for the breakpoints of chr5:58334686-chr15:78640269

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Dchr5:58334685chr15:78640268ENST00000340635-61542_88307.0810.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334685chr15:78640268ENST00000360047-61542_88171.0674.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334685chr15:78640268ENST00000405755-61542_88185.0688.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334685chr15:78640268ENST00000502484-81742_88246.0749.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334685chr15:78640268ENST00000503258-61542_88177.0680.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334685chr15:78640268ENST00000507116-61542_88243.0746.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334685chr15:78640268ENST00000546160-71642_88246.0749.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr15:78640269ENST00000340635-61542_88307.0810.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr15:78640269ENST00000360047-61542_88171.0674.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr15:78640269ENST00000405755-61542_88185.0688.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr15:78640269ENST00000502484-81742_88246.0749.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr15:78640269ENST00000503258-61542_88177.0680.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr15:78640269ENST00000507116-61542_88243.0746.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr15:78640269ENST00000546160-71642_88246.0749.0Compositional biasNote=Pro-rich
TgeneCRABP1chr5:58334685chr15:78640268ENST0000029952924132_134121.0138.0RegionRetinoic acid binding
TgeneCRABP1chr5:58334686chr15:78640269ENST0000029952924132_134121.0138.0RegionRetinoic acid binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Dchr5:58334685chr15:78640268ENST00000317118-11042_880519.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334685chr15:78640268ENST00000358923-21142_885.0508.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334685chr15:78640268ENST00000502575-1642_880220.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr15:78640269ENST00000317118-11042_880519.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr15:78640269ENST00000358923-21142_885.0508.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr15:78640269ENST00000502575-1642_880220.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334685chr15:78640268ENST00000317118-110386_7150519.0DomainPDEase
HgenePDE4Dchr5:58334685chr15:78640268ENST00000340635-615386_715307.0810.0DomainPDEase
HgenePDE4Dchr5:58334685chr15:78640268ENST00000358923-211386_7155.0508.0DomainPDEase
HgenePDE4Dchr5:58334685chr15:78640268ENST00000360047-615386_715171.0674.0DomainPDEase
HgenePDE4Dchr5:58334685chr15:78640268ENST00000405755-615386_715185.0688.0DomainPDEase
HgenePDE4Dchr5:58334685chr15:78640268ENST00000502484-817386_715246.0749.0DomainPDEase
HgenePDE4Dchr5:58334685chr15:78640268ENST00000502575-16386_7150220.0DomainPDEase
HgenePDE4Dchr5:58334685chr15:78640268ENST00000503258-615386_715177.0680.0DomainPDEase
HgenePDE4Dchr5:58334685chr15:78640268ENST00000507116-615386_715243.0746.0DomainPDEase
HgenePDE4Dchr5:58334685chr15:78640268ENST00000546160-716386_715246.0749.0DomainPDEase
HgenePDE4Dchr5:58334686chr15:78640269ENST00000317118-110386_7150519.0DomainPDEase
HgenePDE4Dchr5:58334686chr15:78640269ENST00000340635-615386_715307.0810.0DomainPDEase
HgenePDE4Dchr5:58334686chr15:78640269ENST00000358923-211386_7155.0508.0DomainPDEase
HgenePDE4Dchr5:58334686chr15:78640269ENST00000360047-615386_715171.0674.0DomainPDEase
HgenePDE4Dchr5:58334686chr15:78640269ENST00000405755-615386_715185.0688.0DomainPDEase
HgenePDE4Dchr5:58334686chr15:78640269ENST00000502484-817386_715246.0749.0DomainPDEase
HgenePDE4Dchr5:58334686chr15:78640269ENST00000502575-16386_7150220.0DomainPDEase
HgenePDE4Dchr5:58334686chr15:78640269ENST00000503258-615386_715177.0680.0DomainPDEase
HgenePDE4Dchr5:58334686chr15:78640269ENST00000507116-615386_715243.0746.0DomainPDEase
HgenePDE4Dchr5:58334686chr15:78640269ENST00000546160-716386_715246.0749.0DomainPDEase
HgenePDE4Dchr5:58334685chr15:78640268ENST00000317118-110462_4660519.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334685chr15:78640268ENST00000340635-615462_466307.0810.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334685chr15:78640268ENST00000358923-211462_4665.0508.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334685chr15:78640268ENST00000360047-615462_466171.0674.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334685chr15:78640268ENST00000405755-615462_466185.0688.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334685chr15:78640268ENST00000502484-817462_466246.0749.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334685chr15:78640268ENST00000502575-16462_4660220.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334685chr15:78640268ENST00000503258-615462_466177.0680.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334685chr15:78640268ENST00000507116-615462_466243.0746.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334685chr15:78640268ENST00000546160-716462_466246.0749.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr15:78640269ENST00000317118-110462_4660519.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr15:78640269ENST00000340635-615462_466307.0810.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr15:78640269ENST00000358923-211462_4665.0508.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr15:78640269ENST00000360047-615462_466171.0674.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr15:78640269ENST00000405755-615462_466185.0688.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr15:78640269ENST00000502484-817462_466246.0749.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr15:78640269ENST00000502575-16462_4660220.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr15:78640269ENST00000503258-615462_466177.0680.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr15:78640269ENST00000507116-615462_466243.0746.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr15:78640269ENST00000546160-716462_466246.0749.0Nucleotide bindingcAMP
TgeneCRABP1chr5:58334685chr15:78640268ENST000002995292421_31121.0138.0MotifNuclear localization signal
TgeneCRABP1chr5:58334686chr15:78640269ENST000002995292421_31121.0138.0MotifNuclear localization signal


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Fusion Gene Sequence for PDE4D-CRABP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000502484_ENST00000299529_TCGA-86-7713-01A_PDE4D_chr5_58334686_-_CRABP1_chr15_78640269_length(transcript)=1266nt_BP=962nt
AAGCACGAGTCCTATAGTTGGCGTACCCTGAGGCCTGCCAGTTCCTGCCTTAATGCATATGTAGTCGTAATTGAGTTCTGACACGGCCTT
GGATGTTTCTGTCCTAAATAGCTGACATTGCATCTTCAAGACTGTCATTCCAGTTGGCTTTTGAGTGGATACGTGCAGTGAGATCATTGA
CACTGGAAACACTAGTTCCCATTTTAATTACTTAAAACACCACGATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTGCCT
CTGAGGAAACACTACATTCCAGTAATGAAGAGGAAGACCCTTTCCGCGGAATGGAACCCTATCTTGTCCGGAGACTTTCATGTCGCAATA
TTCAGCTTCCCCCTCTCGCCTTCAGACAGTTGGAACAAGCTGACTTGAAAAGTGAATCAGAGAACATTCAACGACCAACCAGCCTCCCCC
TGAAGATTCTGCCGCTGATTGCTATCACTTCTGCAGAATCCAGTGGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGG
ATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACA
GCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTG
CTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCA
TGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGT
GTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGACGTTTGGCGCCGATGACGTGGTCTGCA
CCAGAATTTATGTCCGAGAGTGAAGGCAGCTGGCTTGCTCCTACTTTCAGGAAGGGATGCAGGCTCCCCTGAGGAATATGTCATAGTTCT
GAGCTGCCAGTGGACCGCCCTTTTCCCCTACCAATATTAGGTGATCCCGTTTTCCCCATGACAATGTTGTAGTGTCCCCCACCCCCACCC
CCCAGGCCTTGGTGCCTCTTGTATCCCTAGTGCTCCATAGTTTGGCATTTGCACGGTTTCGAAGTCATTAAACTGGTTAGACGTGTCTCA

>In-frame_ENST00000502484_ENST00000299529_TCGA-86-7713-01A_PDE4D_chr5_58334686_-_CRABP1_chr15_78640269_length(amino acids)=262AA_start in transcript=224_stop in transcript=1012
MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESS
GFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFA

--------------------------------------------------------------
>In-frame_ENST00000502484_ENST00000299529_TCGA-86-7713_PDE4D_chr5_58334685_-_CRABP1_chr15_78640268_length(transcript)=1266nt_BP=962nt
AAGCACGAGTCCTATAGTTGGCGTACCCTGAGGCCTGCCAGTTCCTGCCTTAATGCATATGTAGTCGTAATTGAGTTCTGACACGGCCTT
GGATGTTTCTGTCCTAAATAGCTGACATTGCATCTTCAAGACTGTCATTCCAGTTGGCTTTTGAGTGGATACGTGCAGTGAGATCATTGA
CACTGGAAACACTAGTTCCCATTTTAATTACTTAAAACACCACGATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTGCCT
CTGAGGAAACACTACATTCCAGTAATGAAGAGGAAGACCCTTTCCGCGGAATGGAACCCTATCTTGTCCGGAGACTTTCATGTCGCAATA
TTCAGCTTCCCCCTCTCGCCTTCAGACAGTTGGAACAAGCTGACTTGAAAAGTGAATCAGAGAACATTCAACGACCAACCAGCCTCCCCC
TGAAGATTCTGCCGCTGATTGCTATCACTTCTGCAGAATCCAGTGGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGG
ATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACA
GCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTG
CTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCA
TGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGT
GTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGACGTTTGGCGCCGATGACGTGGTCTGCA
CCAGAATTTATGTCCGAGAGTGAAGGCAGCTGGCTTGCTCCTACTTTCAGGAAGGGATGCAGGCTCCCCTGAGGAATATGTCATAGTTCT
GAGCTGCCAGTGGACCGCCCTTTTCCCCTACCAATATTAGGTGATCCCGTTTTCCCCATGACAATGTTGTAGTGTCCCCCACCCCCACCC
CCCAGGCCTTGGTGCCTCTTGTATCCCTAGTGCTCCATAGTTTGGCATTTGCACGGTTTCGAAGTCATTAAACTGGTTAGACGTGTCTCA

>In-frame_ENST00000502484_ENST00000299529_TCGA-86-7713_PDE4D_chr5_58334685_-_CRABP1_chr15_78640268_length(amino acids)=262AA_start in transcript=224_stop in transcript=1012
MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESS
GFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PDE4D-CRABP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDE4D-CRABP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDE4D-CRABP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDE4DC3553250ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePDE4DC0011581Depressive disorder3PSYGENET
HgenePDE4DC0004096Asthma2CTD_human
HgenePDE4DC0011570Mental Depression2PSYGENET
HgenePDE4DC0033578Prostatic Neoplasms2CTD_human
HgenePDE4DC0220659Acrodysostosis2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgenePDE4DC0376358Malignant neoplasm of prostate2CTD_human
HgenePDE4DC0036341Schizophrenia1PSYGENET
HgenePDE4DC0236733Amphetamine-Related Disorders1CTD_human
HgenePDE4DC0236804Amphetamine Addiction1CTD_human
HgenePDE4DC0236807Amphetamine Abuse1CTD_human
HgenePDE4DC3276228ACRODYSOSTOSIS 1 WITH OR WITHOUT HORMONE RESISTANCE1CTD_human;GENOMICS_ENGLAND
TgeneCRABP1C0007134Renal Cell Carcinoma1CTD_human
TgeneCRABP1C0022548Keloid1CTD_human
TgeneCRABP1C0023903Liver neoplasms1CTD_human
TgeneCRABP1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneCRABP1C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneCRABP1C0345904Malignant neoplasm of liver1CTD_human
TgeneCRABP1C1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneCRABP1C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneCRABP1C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneCRABP1C1306837Papillary Renal Cell Carcinoma1CTD_human