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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDE4D-NLK (FusionGDB2 ID:63330)

Fusion Gene Summary for PDE4D-NLK

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE4D-NLK
Fusion gene ID: 63330
HgeneTgene
Gene symbol

PDE4D

NLK

Gene ID

5144

51701

Gene namephosphodiesterase 4Dnemo like kinase
SynonymsACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1-
Cytomap

5q11.2-q12.1

17q11.2

Type of geneprotein-codingprotein-coding
DescriptioncAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136serine/threonine-protein kinase NLK
Modification date2020031320200313
UniProtAcc.

Q9UBE8

Ensembl transtripts involved in fusion geneENST00000340635, ENST00000360047, 
ENST00000507116, ENST00000502484, 
ENST00000546160, ENST00000502575, 
ENST00000358923, ENST00000503258, 
ENST00000405755, ENST00000317118, 
ENST00000503947, 		ENST00000407008, 
ENST00000583517, ENST00000582037, 
Fusion gene scores* DoF score40 X 32 X 12=1536010 X 10 X 5=500
# samples 5615
** MAII scorelog2(56/15360*10)=-4.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/500*10)=-1.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDE4D [Title/Abstract] AND NLK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDE4D(59284315)-NLK(26449629), # samples:1
Anticipated loss of major functional domain due to fusion event.PDE4D-NLK seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PDE4D-NLK seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PDE4D-NLK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
PDE4D-NLK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNLK

GO:0050821

protein stabilization

25512613


check buttonFusion gene breakpoints across PDE4D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NLK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-6499PDE4Dchr5

59284315

-NLKchr17

26449629

+


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Fusion Gene ORF analysis for PDE4D-NLK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000340635ENST00000407008PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000340635ENST00000583517PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000340635ENST00000582037PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-3CDSENST00000360047ENST00000407008PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000360047ENST00000583517PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000360047ENST00000582037PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-3CDSENST00000507116ENST00000407008PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000507116ENST00000583517PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000507116ENST00000582037PDE4Dchr5

59284315

-NLKchr17

26449629

+
Frame-shiftENST00000502484ENST00000407008PDE4Dchr5

59284315

-NLKchr17

26449629

+
5CDS-intronENST00000502484ENST00000583517PDE4Dchr5

59284315

-NLKchr17

26449629

+
5CDS-intronENST00000502484ENST00000582037PDE4Dchr5

59284315

-NLKchr17

26449629

+
In-frameENST00000546160ENST00000407008PDE4Dchr5

59284315

-NLKchr17

26449629

+
5CDS-intronENST00000546160ENST00000583517PDE4Dchr5

59284315

-NLKchr17

26449629

+
5CDS-intronENST00000546160ENST00000582037PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-3CDSENST00000502575ENST00000407008PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000502575ENST00000583517PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000502575ENST00000582037PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-3CDSENST00000358923ENST00000407008PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000358923ENST00000583517PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000358923ENST00000582037PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-3CDSENST00000503258ENST00000407008PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000503258ENST00000583517PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000503258ENST00000582037PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-3CDSENST00000405755ENST00000407008PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000405755ENST00000583517PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000405755ENST00000582037PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-3CDSENST00000317118ENST00000407008PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000317118ENST00000583517PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000317118ENST00000582037PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-3CDSENST00000503947ENST00000407008PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000503947ENST00000583517PDE4Dchr5

59284315

-NLKchr17

26449629

+
intron-intronENST00000503947ENST00000582037PDE4Dchr5

59284315

-NLKchr17

26449629

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000546160PDE4Dchr559284315-ENST00000407008NLKchr1726449629+314327201397465

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000546160ENST00000407008PDE4Dchr559284315-NLKchr1726449629+0.0003559820.99964404

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Fusion Genomic Features for PDE4D-NLK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PDE4Dchr559284314-NLKchr1726449628+2.35E-070.99999976
PDE4Dchr559284314-NLKchr1726449628+2.35E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDE4D-NLK


check button Go to

FGviewer for the breakpoints of chr5:59284315-chr17:26449629

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NLK

Q9UBE8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613). {ECO:0000250|UniProtKB:O54949, ECO:0000269|PubMed:12482967, ECO:0000269|PubMed:14960582, ECO:0000269|PubMed:15004007, ECO:0000269|PubMed:15764709, ECO:0000269|PubMed:20061393, ECO:0000269|PubMed:20118921, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:25512613}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Dchr5:59284315chr17:26449629ENST00000502484-31742_8890.66666666666667749.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59284315chr17:26449629ENST00000546160-21642_8890.66666666666667749.0Compositional biasNote=Pro-rich
TgeneNLKchr5:59284315chr17:26449629ENST00000407008011298_300152.66666666666666528.0MotifNote=TQE
TgeneNLKchr5:59284315chr17:26449629ENST00000407008011428_527152.66666666666666528.0RegionRequired for homodimerization and kinase activation and localization to the nucleus

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Dchr5:59284315chr17:26449629ENST00000317118-11042_880519.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59284315chr17:26449629ENST00000340635-11542_880810.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59284315chr17:26449629ENST00000358923-11142_880508.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59284315chr17:26449629ENST00000360047-11542_880674.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59284315chr17:26449629ENST00000405755-11542_880688.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59284315chr17:26449629ENST00000502575-1642_880220.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59284315chr17:26449629ENST00000503258-11542_880680.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59284315chr17:26449629ENST00000507116-11542_880746.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:59284315chr17:26449629ENST00000317118-110386_7150519.0DomainPDEase
HgenePDE4Dchr5:59284315chr17:26449629ENST00000340635-115386_7150810.0DomainPDEase
HgenePDE4Dchr5:59284315chr17:26449629ENST00000358923-111386_7150508.0DomainPDEase
HgenePDE4Dchr5:59284315chr17:26449629ENST00000360047-115386_7150674.0DomainPDEase
HgenePDE4Dchr5:59284315chr17:26449629ENST00000405755-115386_7150688.0DomainPDEase
HgenePDE4Dchr5:59284315chr17:26449629ENST00000502484-317386_71590.66666666666667749.0DomainPDEase
HgenePDE4Dchr5:59284315chr17:26449629ENST00000502575-16386_7150220.0DomainPDEase
HgenePDE4Dchr5:59284315chr17:26449629ENST00000503258-115386_7150680.0DomainPDEase
HgenePDE4Dchr5:59284315chr17:26449629ENST00000507116-115386_7150746.0DomainPDEase
HgenePDE4Dchr5:59284315chr17:26449629ENST00000546160-216386_71590.66666666666667749.0DomainPDEase
HgenePDE4Dchr5:59284315chr17:26449629ENST00000317118-110462_4660519.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59284315chr17:26449629ENST00000340635-115462_4660810.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59284315chr17:26449629ENST00000358923-111462_4660508.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59284315chr17:26449629ENST00000360047-115462_4660674.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59284315chr17:26449629ENST00000405755-115462_4660688.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59284315chr17:26449629ENST00000502484-317462_46690.66666666666667749.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59284315chr17:26449629ENST00000502575-16462_4660220.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59284315chr17:26449629ENST00000503258-115462_4660680.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59284315chr17:26449629ENST00000507116-115462_4660746.0Nucleotide bindingcAMP
HgenePDE4Dchr5:59284315chr17:26449629ENST00000546160-216462_46690.66666666666667749.0Nucleotide bindingcAMP
TgeneNLKchr5:59284315chr17:26449629ENST00000407008011106_111152.66666666666666528.0Compositional biasNote=Poly-Ala
TgeneNLKchr5:59284315chr17:26449629ENST00000407008011115_119152.66666666666666528.0Compositional biasNote=Poly-Ala
TgeneNLKchr5:59284315chr17:26449629ENST0000040700801122_25152.66666666666666528.0Compositional biasNote=Poly-Ala
TgeneNLKchr5:59284315chr17:26449629ENST0000040700801127_34152.66666666666666528.0Compositional biasNote=Poly-His
TgeneNLKchr5:59284315chr17:26449629ENST0000040700801142_48152.66666666666666528.0Compositional biasNote=Poly-His
TgeneNLKchr5:59284315chr17:26449629ENST0000040700801171_83152.66666666666666528.0Compositional biasNote=Poly-Ala
TgeneNLKchr5:59284315chr17:26449629ENST00000407008011138_427152.66666666666666528.0DomainProtein kinase
TgeneNLKchr5:59284315chr17:26449629ENST00000407008011144_152152.66666666666666528.0Nucleotide bindingATP


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Fusion Gene Sequence for PDE4D-NLK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000546160_ENST00000407008_TCGA-G9-6499_PDE4D_chr5_59284315_-_NLK_chr17_26449629_length(transcript)=3143nt_BP=272nt
ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTGCCTCTGAGGAAACACTACATTCCAGTAATGAAGAGGAAGACCCTTTC
CGCGGAATGGAACCCTATCTTGTCCGGAGACTTTCATGTCGCAATATTCAGCTTCCCCCTCTCGCCTTCAGACAGTTGGAACAAGCTGAC
TTGAAAAGTGAATCAGAGAACATTCAACGACCAACCAGCCTCCCCCTGAAGATTCTGCCGCTGATTGCTATCACTTCTGCAGAATCCAGT
GGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAAAGGGTC
TTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATGTACTCTCTGCCCTTGACATACTCCAACCTCCACACATTGACTATTTT
GAAGAAATATATGTTGTCACAGAATTGATGCAGAGTGACCTACATAAAATTATCGTCTCTCCTCAACCACTCAGCTCAGATCATGTCAAA
GTTTTTCTTTATCAGATTTTGCGAGGTTTGAAATATCTCCATTCAGCTGGCATTTTACATCGAGACATTAAGCCAGGGAATCTCCTTGTG
AACAGCAACTGTGTTCTAAAGATTTGTGATTTTGGATTGGCCAGAGTGGAAGAATTAGATGAATCCCGTCATATGACTCAGGAAGTTGTT
ACTCAGTATTATCGGGCTCCAGAAATCCTGATGGGCAGCCGTCATTACAGCAATGCTATTGACATCTGGTCTGTGGGATGTATCTTTGCA
GAACTACTAGGACGAAGAATATTGTTTCAGGCACAGAGTCCCATTCAGCAGTTGGATTTGATCACGGATCTGTTGGGCACACCATCACTG
GAAGCAATGAGGACAGCTTGTGAAGGCGCTAAGGCACATATACTCAGGGGTCCTCATAAACAGCCATCTCTTCCTGTACTCTATACCCTG
TCTAGCCAGGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTGGTCTTTGATCCATCCAAAAGAATATCCGCTAAGGATGCCTTA
GCCCACCCCTACCTAGATGAAGGGCGACTACGATATCACACATGTATGTGTAAATGTTGCTTTTCCACCTCCACTGGAAGAGTTTATACC
AGTGACTTTGAGCCTGTCACCAATCCCAAATTTGATGACACTTTCGAGAAGAACCTCAGTTCTGTCCGACAGGTTAAAGAAATTATTCAT
CAGTTCATTTTGGAACAGCAGAAAGGAAACAGAGTGCCTCTCTGCATCAACCCTCAGTCTGCTGCTTTTAAGAGCTTTATTAGTTCCACT
GTTGCTCAGCCATCTGAGATGCCCCCATCTCCTCTGGTGTGGGAGTGATGGTGGAAGATAATGTACTACTGAAGATGTAATGTAGCTTTC
CACTGGAGTCTGGGATTTGCAATTCTGGAGGTTAATCATGCTTGTACTGTAATTTTACTAATGAAGTTTTAAATTAACAACCACTACTTG
TATGATATGAATAATATTTAGAAATGTTACTAGACTTTTAATCTTGTAAAGTGGTTGTGCTTTTAGAAGAAAAATATTTTACCCAGAGTT
GCACATGTTTTATGAATTTAGTGCAGCTGTTATGGCTCACCTCAGAACAAAAGAGAATTGAACCAAATTTGGGAGTTTGGGGTTTTATGT
TTTGTTTTTCTTTTCTAAAATGAAGTGAGATTGTTCACACACACACACACACACACACACACACACAAACACAAAGGACAGTCATACATT
TTGATATTTGAGCCATTCCTAAAGATTTGGGGTTTTCTAAAACTAAAGAATCTAGGAACCTTGCCTGCGACCAATCATGGAGCCACGTGA
GCTGATCGTGGCTGCACCTGGGGGGAGGGTAGGGAGGAGGGGCATGCCACCTAATGATCAAGCCCTATAATTAGCTTCTCATTAGAGCCG
TGATGGTGATGTGTGCTGTCTAAAATCCAATGTTGTGGGTAGAGAGAATGAGTTTGTGACTAGGAGAGACTAAACTTTTGTTTTCCTTAC
CCAGTATAAATATATATATATATATTTAATCTATTTTTATTAGAAGTTTTTCTGCTCTTTCTTACATAAAAGAACCCCAAGCATGCATCT
TTCATGTGTGTAAATAATTCATTTCTGGGCTAATTTCAAAAGAATCCCAATATTGCTGTATAGAAAGAGAACTAGCTTGCACATTTTAGG
TCTGTGAAATTTTGTGAGACTTTTCCTGCACTGGACAGTAAAAAAATAATAAAAGACAAAAACAAATTTAAAAAAAAATTTAAGCCACAA
AAAAAGGCACATAGGGAATTATGTCAAATGTGTTTGTGTCCTTAGGCAAAGCTGTGGGAGTCTTGAAATGTCACAGTAGTAAATAACTTA
TTACTTTTTGACAAGTTCTTTTTTTCTGTTGGAACACTGAATTCTTCTGTGCATATGTACATATGAATACAAATCGAAGGCCTCTACCTC
CTGGAGTTATACAACTTGGCTTGTTTACCTCCACATGCTGATGATGACTATTTTTTTTTTTTGAGTTCAGTGTGGAGACTTGAAACTTGA
ATGTCCCTTCCAACTTTTATATTAAAAATAAAAAGACAAGAAAATTGAAGATCATTTTTCACCTGTACAAGGAATACTAATGGATCGTCT
TAAAATTGGTCTAGGAAAAAACCTTGGTGTGTGTTATGGACAATTAACTGTTAAAGTTATTGTAAGTTATCTGTATTTAGCAGAGTATTT
TCAACTTGAGTGATCTGAGCTGAATTTGAAGACTATTAATAAGTTATGTTTGGAAGTTTTAACTTCAATGAAGTAATTATTTGCTGTGAA
AGAAACAAACATTGAATTACTAAACAAAGATGGTGCAATATCTTTGTTTTTTTTTTATGAGGCTCCTGAGAATCAACCCAACTGAAGCAT
TTCAATTCACTTGAATGAGAAACGTGTTTAGTATCAAAAGAGCCCAAGAAGACACTGGTGTGAAAGGTACAATCTCAGAGGTTGGTCAAT

>In-frame_ENST00000546160_ENST00000407008_TCGA-G9-6499_PDE4D_chr5_59284315_-_NLK_chr17_26449629_length(amino acids)=465AA_start in transcript=0_stop in transcript=1397
MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESS
GSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVK
VFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFA
ELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDAL
AHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISST

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PDE4D-NLK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDE4D-NLK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDE4D-NLK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDE4DC3553250ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePDE4DC0011581Depressive disorder3PSYGENET
HgenePDE4DC0004096Asthma2CTD_human
HgenePDE4DC0011570Mental Depression2PSYGENET
HgenePDE4DC0033578Prostatic Neoplasms2CTD_human
HgenePDE4DC0220659Acrodysostosis2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgenePDE4DC0376358Malignant neoplasm of prostate2CTD_human
HgenePDE4DC0036341Schizophrenia1PSYGENET
HgenePDE4DC0236733Amphetamine-Related Disorders1CTD_human
HgenePDE4DC0236804Amphetamine Addiction1CTD_human
HgenePDE4DC0236807Amphetamine Abuse1CTD_human
HgenePDE4DC3276228ACRODYSOSTOSIS 1 WITH OR WITHOUT HORMONE RESISTANCE1CTD_human;GENOMICS_ENGLAND