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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PDE4D-NOA1 (FusionGDB2 ID:63331)

Fusion Gene Summary for PDE4D-NOA1

Fusion gene summary

Fusion gene information	Fusion gene name: PDE4D-NOA1
	Fusion gene ID: 63331
		Hgene	Tgene
	Gene symbol	PDE4D	NOA1
	Gene ID	5144	84273
	Gene name	phosphodiesterase 4D	nitric oxide associated 1
	Synonyms	ACRDYS2\|DPDE3\|HSPDE4D\|PDE43\|PDE4DN2\|STRK1	C4orf14\|MTG3\|hAtNOS1\|hNOA1\|mAtNOS1
	Cytomap	5q11.2-q12.1	4q12
	Type of gene	protein-coding	protein-coding
	Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136	nitric oxide-associated protein 1mitochondrial GTPase 3 homolognitric oxide synthase, mitochondrial (putative)putative ortholog of Arabidopsis mitochondrial nitric oxide synthase
	Modification date	20200313	20200313
	UniProtAcc	.	Q8NC60
	Ensembl transtripts involved in fusion gene	ENST00000340635, ENST00000360047, ENST00000507116, ENST00000502484, ENST00000546160, ENST00000502575, ENST00000358923, ENST00000503258, ENST00000405755, ENST00000317118, ENST00000503947,	ENST00000264230,
Fusion gene scores	* DoF score	40 X 32 X 12=15360	3 X 2 X 3=18
	# samples	56	3
	** MAII score	log2(56/15360*10)=-4.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PDE4D [Title/Abstract] AND NOA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PDE4D(58476421)-NOA1(57840188), # samples:1
Anticipated loss of major functional domain due to fusion event.	PDE4D-NOA1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PDE4D-NOA1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PDE4D-NOA1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PDE4D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NOA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-KD-A5QU-01A	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-

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Fusion Gene ORF analysis for PDE4D-NOA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000340635	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-
In-frame	ENST00000360047	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-
In-frame	ENST00000507116	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-
Frame-shift	ENST00000502484	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-
In-frame	ENST00000546160	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-
In-frame	ENST00000502575	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-
intron-3CDS	ENST00000358923	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-
In-frame	ENST00000503258	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-
In-frame	ENST00000405755	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-
intron-3CDS	ENST00000317118	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-
5UTR-3CDS	ENST00000503947	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000340635	PDE4D	chr5	58476421	-	ENST00000264230	NOA1	chr4	57840188	-	2017	984	176	1936	586
ENST00000360047	PDE4D	chr5	58476421	-	ENST00000264230	NOA1	chr4	57840188	-	1557	524	31	1476	481
ENST00000507116	PDE4D	chr5	58476421	-	ENST00000264230	NOA1	chr4	57840188	-	1785	752	7	1704	565
ENST00000546160	PDE4D	chr5	58476421	-	ENST00000264230	NOA1	chr4	57840188	-	1658	625	0	1577	525
ENST00000502575	PDE4D	chr5	58476421	-	ENST00000264230	NOA1	chr4	57840188	-	1776	743	49	1695	548
ENST00000503258	PDE4D	chr5	58476421	-	ENST00000264230	NOA1	chr4	57840188	-	2168	1135	717	2087	456
ENST00000405755	PDE4D	chr5	58476421	-	ENST00000264230	NOA1	chr4	57840188	-	1604	571	102	1523	473

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000340635	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-	0.0072329	0.9927671
ENST00000360047	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-	0.000267861	0.9997321
ENST00000507116	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-	0.001368958	0.99863106
ENST00000546160	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-	0.000408503	0.9995915
ENST00000502575	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-	0.001278343	0.99872166
ENST00000503258	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-	0.001064078	0.9989359
ENST00000405755	ENST00000264230	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-	0.000355286	0.99964476

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Fusion Genomic Features for PDE4D-NOA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDE4D-NOA1

Go to
FGviewer for the breakpoints of chr5:58476421-chr4:57840188
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NOA1 Q8NC60
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP. {ECO:0000269\|PubMed:19103604}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000340635

42_88

269.3333333333333

810.0

Compositional bias

Note=Pro-rich

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000360047

42_88

133.33333333333334

674.0

Compositional bias

Note=Pro-rich

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000405755

42_88

147.33333333333334

688.0

Compositional bias

Note=Pro-rich

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000502484

42_88

208.33333333333334

749.0

Compositional bias

Note=Pro-rich

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000502575

42_88

205.33333333333334

220.0

Compositional bias

Note=Pro-rich

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000503258

42_88

139.33333333333334

680.0

Compositional bias

Note=Pro-rich

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000507116

42_88

205.33333333333334

746.0

Compositional bias

Note=Pro-rich

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000546160

42_88

208.33333333333334

749.0

Compositional bias

Note=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000317118

42_88

519.0

Compositional bias

Note=Pro-rich

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000358923

42_88

508.0

Compositional bias

Note=Pro-rich

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000317118

386_715

519.0

Domain

PDEase

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000340635

386_715

269.3333333333333

810.0

Domain

PDEase

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000358923

386_715

508.0

Domain

PDEase

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000360047

386_715

133.33333333333334

674.0

Domain

PDEase

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000405755

386_715

147.33333333333334

688.0

Domain

PDEase

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000502484

386_715

208.33333333333334

749.0

Domain

PDEase

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000502575

386_715

205.33333333333334

220.0

Domain

PDEase

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000503258

386_715

139.33333333333334

680.0

Domain

PDEase

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000507116

386_715

205.33333333333334

746.0

Domain

PDEase

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000546160

386_715

208.33333333333334

749.0

Domain

PDEase

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000317118

462_466

519.0

Nucleotide binding

cAMP

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000340635

462_466

269.3333333333333

810.0

Nucleotide binding

cAMP

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000358923

462_466

508.0

Nucleotide binding

cAMP

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000360047

462_466

133.33333333333334

674.0

Nucleotide binding

cAMP

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000405755

462_466

147.33333333333334

688.0

Nucleotide binding

cAMP

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000502484

462_466

208.33333333333334

749.0

Nucleotide binding

cAMP

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000502575

462_466

205.33333333333334

220.0

Nucleotide binding

cAMP

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000503258

462_466

139.33333333333334

680.0

Nucleotide binding

cAMP

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000507116

462_466

205.33333333333334

746.0

Nucleotide binding

cAMP

Hgene

PDE4D

chr5:58476421

chr4:57840188

ENST00000546160

462_466

208.33333333333334

749.0

Nucleotide binding

cAMP

Tgene

NOA1

chr5:58476421

chr4:57840188

ENST00000264230

202_503

381.3333333333333

699.0

Domain

CP-type G

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Fusion Gene Sequence for PDE4D-NOA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000340635_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(transcript)=2017nt_BP=984nt
GGGCCCCCTCTCGGTAGCCCTGAGGCTCTGGCGCCTTCAAGTGAGAAGCTAAGCACCAGCCTCTGCTGGGCTGCAGAAGCGGCGGCGGCG
GCAGCAGCAGCAGCAGCATCAGGAAGGCGCTCGGGCCAGCGCGGTGAACCCGGGCTGGGCAGCAGGTCGCGGAGCCGCGAGCCAGGATGG
AGGCAGAGGGCAGCAGCGCGCCGGCCCGGGCGGGCAGCGGAGAGGGCAGCGACAGCGCCGGCGGGGCCACGCTCAAAGCCCCCAAGCATC
TCTGGAGGCACGAGCAGCACCACCAGTACCCGCTCCGGCAGCCCCAGTTCCGCCTCCTGCATCCCCATCACCACCTGCCCCCGCCGCCGC
CACCCTCGCCCCAGCCCCAGCCCCAGTGTCCGCTACAGCCGCCGCCGCCGCCCCCCCTGCCGCCGCCCCCGCCGCCGCCCGGGGCTGCCC
GCGGCCGCTACGCCTCGAGCGGGGCCACCGGCCGCGTCCGGCATCGCGGCTACTCGGACACCGAGCGCTACCTGTACTGTCGCGCCATGG
ACCGCACCTCCTACGCGGTGGAGACCGGCCACCGGCCCGGCCTGAAGAAATCCAGGATGTCCTGGCCCTCCTCGTTCCAGGGACTCAGGC
GTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATT
TTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCA
TTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTG
CATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACTA
CATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAG
CTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCT
TGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTA
CACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAA
ATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAG
GAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCC
TCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAA
AAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCA
AGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGA
CCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTT
CCCTTATGTACAACGTGAGGAAGAAGAAAGGAAAGATAAATGTATGAGACCGACCTTGTTCACTCCAGATATTAACTGTATTGAACACAA

>In-frame_ENST00000340635_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(amino acids)=586AA_start in transcript=176_stop in transcript=1936
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGA
ARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITG
TTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVM
GTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASN
ILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTV

--------------------------------------------------------------
>In-frame_ENST00000360047_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(transcript)=1557nt_BP=524nt
CAATACTTGTTGCAATAATTGCCCACGATAGCTGCTCAAACAAGAGAGTTGGAATTCATCTGTAAAAATCACTACATGTAACGTAGGAGA
CAAGAAAAATATTAATGACAGAAGATCTGCGAACATGATGCACGTGAATAATTTTCCCTTTAGAAGGCATTCCTGGATATGTTTTGATGT
GGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAG
TCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGA
TATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAA
TTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACTACATTAAACCT
TCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAAGA
TCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCAGA
AGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACACACAAATC
CACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAATTGTATTTT
AAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTTCT
GTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTGCA
TATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGAAT
GGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCCTC
TGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGGCC
CCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATGTA
CAACGTGAGGAAGAAGAAAGGAAAGATAAATGTATGAGACCGACCTTGTTCACTCCAGATATTAACTGTATTGAACACAACAAAATACAT

>In-frame_ENST00000360047_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(amino acids)=481AA_start in transcript=31_stop in transcript=1476
MLKQESWNSSVKITTCNVGDKKNINDRRSANMMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRS
DSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITGTTLNLLKFPICNPTP
YRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQD
VKDAHWFYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADAL
YQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIK

--------------------------------------------------------------
>In-frame_ENST00000507116_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(transcript)=1785nt_BP=752nt
AGAGAGACTGAGGCAGGCGACTGAATGCACTAACAGCAGCAGGCTCAGACCTGCTTCCCTGGACATTTCCGGGACCGTGAGCGAGGGAAC
CACGTTGCCCTGGATTCTTGCCAGCTGTACAAAGTTGACCAGGAAAATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGT
GGATAATCCGCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTGAAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGAC
AGCGAGGAAATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCGAGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAA
CATCCCCAAACAGCGGCGTTTCACGGTGGCACATACATGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCAT
GACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTA
TGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGT
CTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAA
CCAACCATCCATCAACAAAGCCACCATAACAGGTACTACATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTT
TAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAA
GCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTC
ACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGC
CCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAAC
ACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAA
TCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCA
TGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAA
AGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACT
GCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCAT
CAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATGTACAACGTGAGGAAGAAGAAAGGAAAGATAAATGTATGAGACCG

>In-frame_ENST00000507116_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(amino acids)=565AA_start in transcript=7_stop in transcript=1704
MRQATECTNSSRLRPASLDISGTVSEGTTLPWILASCTKLTRKMAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTAR
KSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTCFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDL
SPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITGTTLNLLKFPICNPTPYRMFKR
HQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHW
FYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAG
HTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKK

--------------------------------------------------------------
>In-frame_ENST00000546160_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(transcript)=1658nt_BP=625nt
ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTGCCTCTGAGGAAACACTACATTCCAGTAATGAAGAGGAAGACCCTTTC
CGCGGAATGGAACCCTATCTTGTCCGGAGACTTTCATGTCGCAATATTCAGCTTCCCCCTCTCGCCTTCAGACAGTTGGAACAAGCTGAC
TTGAAAAGTGAATCAGAGAACATTCAACGACCAACCAGCCTCCCCCTGAAGATTCTGCCGCTGATTGCTATCACTTCTGCAGAATCCAGT
GGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAAT
TTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCC
ATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCT
GCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACT
ACATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAA
GCTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTC
TTGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGT
ACACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAA
AATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCA
GGAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATC
CTCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGA
AAAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATC
AAGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTG
ACCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCT
TCCCTTATGTACAACGTGAGGAAGAAGAAAGGAAAGATAAATGTATGAGACCGACCTTGTTCACTCCAGATATTAACTGTATTGAACACA

>In-frame_ENST00000546160_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(amino acids)=525AA_start in transcript=0_stop in transcript=1577
MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESS
GFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFA
ALTNLQDRAPSKRSPMCNQPSINKATITGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTF
LYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKP
GMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADI

--------------------------------------------------------------
>In-frame_ENST00000502575_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(transcript)=1776nt_BP=743nt
GAGGCAGGCGACTGAATGCACTAACAGCAGCAGGCTCAGACCTGCTTCCCTGGACATTTCCGGGACCGTGAGCGAGGGAACCACGTTGCC
CTGGATTCTTGCCAGCTGTACAAAGTTGACCAGGAAAATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGTGGATAATCC
GCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTGAAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGACAGCGAGGAA
ATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCGAGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAACATCCCCAA
ACAGCGGCGTTTCACGGTGGCACATACATGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCC
AGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTC
TCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAG
TCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATC
CATCAACAAAGCCACCATAACAGGTACTACATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCA
TCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTA
TGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTT
TGACATGGAAAATGACCCTGTTATGGGTACACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTT
TTATGACACCCCTGGAATTACAAAAGAAAATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCAT
TGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGC
TTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCA
TACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACT
GGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCG
AGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAG
TGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATGTACAACGTGAGGAAGAAGAAAGGAAAGATAAATGTATGAGACCGACCTTGTTC

>In-frame_ENST00000502575_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(amino acids)=548AA_start in transcript=49_stop in transcript=1695
MDISGTVSEGTTLPWILASCTKLTRKMAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTARKSVSPKLSPVISPRNSP
RLLRRMLLSSNIPKQRRFTVAHTCFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHG
DDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSE
QEQNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLL
TEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGF
PPLVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKKSVAYKTKKPPSLMYNVR

--------------------------------------------------------------
>In-frame_ENST00000503258_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(transcript)=2168nt_BP=1135nt
TTCTCACTGCCCTGCGGTGTTTTGAACTGCCTTCTTACAGACGTCATACAGCCCTTGAGGAATAGTTTCTGCCTGGTGAGATTGAATGAT
AGTTCTCATTCACAAAACCCTGGATTCTAAGCAGGGACACACAGAAATTACTTTCGCAGGTAAATCAGCCCACCCAGCCAAAGTGTGGAG
AGATTTGTTCCTTGGCTGACTTCTTTGCTCCACGGAGAGGAGTGTTTTCCTGTGCTTGCCCTGAAATGGAACTTCCTTGACAGCTCTCCC
GTGTTACAGTACCTCCCGGTCATTTTCTTTTTCTCTCTCTCTACCTGCGCTCTTCGAGTGTCAGAAACCTTTAAAGCTGTTACTATGGAA
TTGCAAAAAAGAGATCAAGTGACTCTTTCACTATGCTGGTTTCCCTTGTGACCCAGATGAAGAATCAATTCAGAATTCAGTTCCTCCCTT
GGCATTGCAAGACACAGAAGAAACTGTCACTTCCTAACAGCCTAGTACTGGAGTAAATTCAGTATGAAGGAAGAAAGCGCTCCTGCGTGT
TAGAACCTTGCCCATGAGCTGGACCGAGGACAGGAGATGGACTCCAGGAAAATTGGATTTCTTCAAGCAGCCTCCCTTGGAAATGGAATA
TCTTTAAAATCTTCTTTGCAGAAAGACAGTTAGAATGTATTAATCAGAATAGTTGAAGACTTATTTTCCTTTTTATTTTTTTTCAAAATG
AGCATTATTATGAAGCCAAGATCCCGATCTACAAGTTCCCTAAGGACTGCAGAGGCAGTTTGTTTTGATGTGGACAATGGCACATCTGCG
GGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTC
CTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTG
ATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCT
AGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACTACATTAAACCTTCTGAAGTTTCCTATTTGC
AACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAAGATCTTAGTGAGCAAGAACAA
AATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCAGAAGAACAGAAGGATAACATT
CCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACACACAAATCCACCAAACAAGTAGAATTG
ACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAATTGTATTTTAAATCTTCTAACAGAAAAA
GAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTTCTGTTTTTGGGTGCTATAGGC
CGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTGCATATCACCTCCTTGGACAGG
GCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGAATGGCAGGATTTCCTCCTCTT
GTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCCTCTGCAGGTTGGGTTTCAGTA
ACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGGCCCCCTCTCTTGCCATATATT
GTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATGTACAACGTGAGGAAGAAGAAA
GGAAAGATAAATGTATGAGACCGACCTTGTTCACTCCAGATATTAACTGTATTGAACACAACAAAATACATTGAATTTGTATTAAACATA

>In-frame_ENST00000503258_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(amino acids)=456AA_start in transcript=717_stop in transcript=2087
MSIIMKPRSRSTSSLRTAEAVCFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDD
LIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQE
QNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTE
KEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPP
LVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKKSVAYKTKKPPSLMYNVRKK

--------------------------------------------------------------
>In-frame_ENST00000405755_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(transcript)=1604nt_BP=571nt
ACTGCACAAAGGAAATGCCCTCACTCAGCTACAAGTGCCTCCTGCTCCGTGCGGGGCCTCAGGGCCCCAGAGCCCCGCACCAGCTCTGAC
TTCTCGTGGTTCCTGGGGATCTTGGCATCGTCCTTAAAAATGGCTTTTGTTTGGGATCCTCTGGGAGCCACGGTGCCAGGACCATCTACA
AGAGCCAAATCAAGATTGCGTTTCTCAAAGTCCTACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATG
ACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTAT
GACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTC
TTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAAC
CAACCATCCATCAACAAAGCCACCATAACAGGTACTACATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTT
AAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAG
CATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCA
CTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCC
CACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACA
CAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAAT
CAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCAT
GCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAA
GAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTG
CATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATC
AAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATGTACAACGTGAGGAAGAAGAAAGGAAAGATAAATGTATGAGACCGA

>In-frame_ENST00000405755_ENST00000264230_TCGA-KD-A5QU-01A_PDE4D_chr5_58476421_-_NOA1_chr4_57840188_length(amino acids)=473AA_start in transcript=102_stop in transcript=1523
MGILASSLKMAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSP
KSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITGTTLNLLKFPICNPTPYRMFKRHQ
RLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFY
DTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHT
LLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKKSV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PDE4D-NOA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PDE4D-NOA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PDE4D-NOA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PDE4D	C3553250	ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	PDE4D	C0011581	Depressive disorder	3	PSYGENET
Hgene	PDE4D	C0004096	Asthma	2	CTD_human
Hgene	PDE4D	C0011570	Mental Depression	2	PSYGENET
Hgene	PDE4D	C0033578	Prostatic Neoplasms	2	CTD_human
Hgene	PDE4D	C0220659	Acrodysostosis	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	PDE4D	C0376358	Malignant neoplasm of prostate	2	CTD_human
Hgene	PDE4D	C0036341	Schizophrenia	1	PSYGENET
Hgene	PDE4D	C0236733	Amphetamine-Related Disorders	1	CTD_human
Hgene	PDE4D	C0236804	Amphetamine Addiction	1	CTD_human
Hgene	PDE4D	C0236807	Amphetamine Abuse	1	CTD_human
Hgene	PDE4D	C3276228	ACRODYSOSTOSIS 1 WITH OR WITHOUT HORMONE RESISTANCE	1	CTD_human;GENOMICS_ENGLAND