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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDGFA-PRKAR1B (FusionGDB2 ID:63425)

Fusion Gene Summary for PDGFA-PRKAR1B

check button Fusion gene summary
Fusion gene informationFusion gene name: PDGFA-PRKAR1B
Fusion gene ID: 63425
HgeneTgene
Gene symbol

PDGFA

PRKAR1B

Gene ID

5154

5575

Gene nameplatelet derived growth factor subunit Aprotein kinase cAMP-dependent type I regulatory subunit beta
SynonymsPDGF-A|PDGF1PRKAR1
Cytomap

7p22.3

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionplatelet-derived growth factor subunit APDGF A-chainPDGF subunit Aplatelet-derived growth factor A-chainplatelet-derived growth factor alpha chainplatelet-derived growth factor alpha polypeptidecAMP-dependent protein kinase type I-beta regulatory subunitprotein kinase, cAMP-dependent, regulatory subunit type I betaprotein kinase, cAMP-dependent, regulatory, type I, beta
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000402802, ENST00000354513, 
ENST00000426681, 		ENST00000544935, 
ENST00000537384, ENST00000406797, 
ENST00000403562, ENST00000360274, 
ENST00000488474, 
Fusion gene scores* DoF score7 X 8 X 6=33614 X 10 X 8=1120
# samples 815
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1120*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDGFA [Title/Abstract] AND PRKAR1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDGFA(550445)-PRKAR1B(619014), # samples:1
PDGFA(550445)-PRKAR1B(635941), # samples:1
PDGFA(550446)-PRKAR1B(619014), # samples:1
Anticipated loss of major functional domain due to fusion event.PDGFA-PRKAR1B seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PDGFA-PRKAR1B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDGFA

GO:0008284

positive regulation of cell proliferation

2439522|2836953|7073684|10806482|16462734|17470632

HgenePDGFA

GO:0009611

response to wounding

2538439

HgenePDGFA

GO:0010512

negative regulation of phosphatidylinositol biosynthetic process

2538439

HgenePDGFA

GO:0010544

negative regulation of platelet activation

2538439

HgenePDGFA

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

11788434

HgenePDGFA

GO:0014910

regulation of smooth muscle cell migration

9409235

HgenePDGFA

GO:0030335

positive regulation of cell migration

11788434|17470632

HgenePDGFA

GO:0031954

positive regulation of protein autophosphorylation

12070119

HgenePDGFA

GO:0035793

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

19019919

HgenePDGFA

GO:0043406

positive regulation of MAP kinase activity

11788434

HgenePDGFA

GO:0048008

platelet-derived growth factor receptor signaling pathway

2439522|2536956|2836953

HgenePDGFA

GO:0048146

positive regulation of fibroblast proliferation

2439522|10806482

HgenePDGFA

GO:0050919

negative chemotaxis

9409235

HgenePDGFA

GO:0051897

positive regulation of protein kinase B signaling

19019919

HgenePDGFA

GO:0070374

positive regulation of ERK1 and ERK2 cascade

11788434

HgenePDGFA

GO:0072124

regulation of glomerular mesangial cell proliferation

11788434

HgenePDGFA

GO:2000278

regulation of DNA biosynthetic process

11788434|19019919

TgenePRKAR1B

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

21812984


check buttonFusion gene breakpoints across PDGFA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PRKAR1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A43MPDGFAchr7

550445

-PRKAR1Bchr7

619014

-
ChimerDB4STADTCGA-CD-5803PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
ChimerDB4ESCATCGA-L5-A43MPDGFAchr7

550446

-PRKAR1Bchr7

619014

-


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Fusion Gene ORF analysis for PDGFA-PRKAR1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000402802ENST00000544935PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
Frame-shiftENST00000402802ENST00000537384PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
Frame-shiftENST00000402802ENST00000406797PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
Frame-shiftENST00000402802ENST00000403562PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
Frame-shiftENST00000402802ENST00000360274PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
5CDS-intronENST00000402802ENST00000488474PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
In-frameENST00000354513ENST00000544935PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
In-frameENST00000354513ENST00000537384PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
In-frameENST00000354513ENST00000406797PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
In-frameENST00000354513ENST00000403562PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
In-frameENST00000354513ENST00000360274PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
5CDS-intronENST00000354513ENST00000488474PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
intron-3CDSENST00000426681ENST00000544935PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
intron-3CDSENST00000426681ENST00000537384PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
intron-3CDSENST00000426681ENST00000406797PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
intron-3CDSENST00000426681ENST00000403562PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
intron-3CDSENST00000426681ENST00000360274PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
intron-intronENST00000426681ENST00000488474PDGFAchr7

550445

-PRKAR1Bchr7

619014

-
In-frameENST00000402802ENST00000544935PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
In-frameENST00000402802ENST00000537384PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
In-frameENST00000402802ENST00000406797PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
In-frameENST00000402802ENST00000403562PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
In-frameENST00000402802ENST00000360274PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
5CDS-intronENST00000402802ENST00000488474PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
Frame-shiftENST00000354513ENST00000544935PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
Frame-shiftENST00000354513ENST00000537384PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
Frame-shiftENST00000354513ENST00000406797PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
Frame-shiftENST00000354513ENST00000403562PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
Frame-shiftENST00000354513ENST00000360274PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
5CDS-intronENST00000354513ENST00000488474PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
intron-3CDSENST00000426681ENST00000544935PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
intron-3CDSENST00000426681ENST00000537384PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
intron-3CDSENST00000426681ENST00000406797PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
intron-3CDSENST00000426681ENST00000403562PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
intron-3CDSENST00000426681ENST00000360274PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
intron-intronENST00000426681ENST00000488474PDGFAchr7

550445

-PRKAR1Bchr7

635941

-
Frame-shiftENST00000402802ENST00000544935PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
Frame-shiftENST00000402802ENST00000537384PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
Frame-shiftENST00000402802ENST00000406797PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
Frame-shiftENST00000402802ENST00000403562PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
Frame-shiftENST00000402802ENST00000360274PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
5CDS-intronENST00000402802ENST00000488474PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
In-frameENST00000354513ENST00000544935PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
In-frameENST00000354513ENST00000537384PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
In-frameENST00000354513ENST00000406797PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
In-frameENST00000354513ENST00000403562PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
In-frameENST00000354513ENST00000360274PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
5CDS-intronENST00000354513ENST00000488474PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
intron-3CDSENST00000426681ENST00000544935PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
intron-3CDSENST00000426681ENST00000537384PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
intron-3CDSENST00000426681ENST00000406797PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
intron-3CDSENST00000426681ENST00000403562PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
intron-3CDSENST00000426681ENST00000360274PDGFAchr7

550446

-PRKAR1Bchr7

619014

-
intron-intronENST00000426681ENST00000488474PDGFAchr7

550446

-PRKAR1Bchr7

619014

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PDGFA-PRKAR1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDGFA-PRKAR1B


check button Go to

FGviewer for the breakpoints of chr7:550445-chr7:619014

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDGFAchr7:550445chr7:619014ENST00000354513-47158_162151.0139.33333333333334RegionReceptor binding site
HgenePDGFAchr7:550445chr7:635941ENST00000354513-47158_162151.0139.33333333333334RegionReceptor binding site
HgenePDGFAchr7:550446chr7:619014ENST00000354513-47158_162151.0139.33333333333334RegionReceptor binding site
TgenePRKAR1Bchr7:550445chr7:619014ENST00000360274711255_381256.3333333333333382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550445chr7:619014ENST00000403562711255_381256.3333333333333382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550445chr7:619014ENST00000406797711255_381256.3333333333333382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550445chr7:619014ENST00000537384711255_381256.3333333333333382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550445chr7:619014ENST00000544935711255_381256.3333333333333382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550445chr7:635941ENST00000360274511255_381183.0382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550445chr7:635941ENST00000403562511255_381183.0382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550445chr7:635941ENST00000406797511255_381183.0382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550445chr7:635941ENST00000537384511255_381183.0382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550445chr7:635941ENST00000544935511255_381183.0382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550446chr7:619014ENST00000360274711255_381256.3333333333333382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550446chr7:619014ENST00000403562711255_381256.3333333333333382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550446chr7:619014ENST00000406797711255_381256.3333333333333382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550446chr7:619014ENST00000537384711255_381256.3333333333333382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:550446chr7:619014ENST00000544935711255_381256.3333333333333382.0Nucleotide bindingNote=cAMP 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDGFAchr7:550445chr7:619014ENST00000402802-46158_162151.0197.0RegionReceptor binding site
HgenePDGFAchr7:550445chr7:635941ENST00000402802-46158_162151.0197.0RegionReceptor binding site
HgenePDGFAchr7:550446chr7:619014ENST00000402802-46158_162151.0197.0RegionReceptor binding site
TgenePRKAR1Bchr7:550445chr7:619014ENST0000036027471196_100256.3333333333333382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550445chr7:619014ENST0000040356271196_100256.3333333333333382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550445chr7:619014ENST0000040679771196_100256.3333333333333382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550445chr7:619014ENST0000053738471196_100256.3333333333333382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550445chr7:619014ENST0000054493571196_100256.3333333333333382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550445chr7:635941ENST0000036027451196_100183.0382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550445chr7:635941ENST0000040356251196_100183.0382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550445chr7:635941ENST0000040679751196_100183.0382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550445chr7:635941ENST0000053738451196_100183.0382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550445chr7:635941ENST0000054493551196_100183.0382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550446chr7:619014ENST0000036027471196_100256.3333333333333382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550446chr7:619014ENST0000040356271196_100256.3333333333333382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550446chr7:619014ENST0000040679771196_100256.3333333333333382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550446chr7:619014ENST0000053738471196_100256.3333333333333382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550446chr7:619014ENST0000054493571196_100256.3333333333333382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:550445chr7:619014ENST00000360274711137_254256.3333333333333382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550445chr7:619014ENST00000403562711137_254256.3333333333333382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550445chr7:619014ENST00000406797711137_254256.3333333333333382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550445chr7:619014ENST00000537384711137_254256.3333333333333382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550445chr7:619014ENST00000544935711137_254256.3333333333333382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550445chr7:635941ENST00000360274511137_254183.0382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550445chr7:635941ENST00000403562511137_254183.0382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550445chr7:635941ENST00000406797511137_254183.0382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550445chr7:635941ENST00000537384511137_254183.0382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550445chr7:635941ENST00000544935511137_254183.0382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550446chr7:619014ENST00000360274711137_254256.3333333333333382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550446chr7:619014ENST00000403562711137_254256.3333333333333382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550446chr7:619014ENST00000406797711137_254256.3333333333333382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550446chr7:619014ENST00000537384711137_254256.3333333333333382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550446chr7:619014ENST00000544935711137_254256.3333333333333382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:550445chr7:619014ENST000003602747112_136256.3333333333333382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550445chr7:619014ENST000004035627112_136256.3333333333333382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550445chr7:619014ENST000004067977112_136256.3333333333333382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550445chr7:619014ENST000005373847112_136256.3333333333333382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550445chr7:619014ENST000005449357112_136256.3333333333333382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550445chr7:635941ENST000003602745112_136183.0382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550445chr7:635941ENST000004035625112_136183.0382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550445chr7:635941ENST000004067975112_136183.0382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550445chr7:635941ENST000005373845112_136183.0382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550445chr7:635941ENST000005449355112_136183.0382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550446chr7:619014ENST000003602747112_136256.3333333333333382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550446chr7:619014ENST000004035627112_136256.3333333333333382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550446chr7:619014ENST000004067977112_136256.3333333333333382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550446chr7:619014ENST000005373847112_136256.3333333333333382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:550446chr7:619014ENST000005449357112_136256.3333333333333382.0RegionNote=Dimerization and phosphorylation


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Fusion Gene Sequence for PDGFA-PRKAR1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PDGFA-PRKAR1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDGFA-PRKAR1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDGFA-PRKAR1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDGFAC0007097Carcinoma2CTD_human
HgenePDGFAC0024667Animal Mammary Neoplasms2CTD_human
HgenePDGFAC0024668Mammary Neoplasms, Experimental2CTD_human
HgenePDGFAC0205696Anaplastic carcinoma2CTD_human
HgenePDGFAC0205697Carcinoma, Spindle-Cell2CTD_human
HgenePDGFAC0205698Undifferentiated carcinoma2CTD_human
HgenePDGFAC0205699Carcinomatosis2CTD_human
HgenePDGFAC1257925Mammary Carcinoma, Animal2CTD_human
HgenePDGFAC0005942Bone Diseases, Endocrine1CTD_human
HgenePDGFAC0006142Malignant neoplasm of breast1CTD_human
HgenePDGFAC0023893Liver Cirrhosis, Experimental1CTD_human
HgenePDGFAC0024115Lung diseases1CTD_human
HgenePDGFAC0025500Mesothelioma1CTD_human
HgenePDGFAC0034069Pulmonary Fibrosis1CTD_human
HgenePDGFAC0040028Thrombocythemia, Essential1CTD_human
HgenePDGFAC0040136Thyroid Neoplasm1CTD_human
HgenePDGFAC0151468Thyroid Gland Follicular Adenoma1CTD_human
HgenePDGFAC0549473Thyroid carcinoma1CTD_human
HgenePDGFAC0678222Breast Carcinoma1CTD_human
HgenePDGFAC1257931Mammary Neoplasms, Human1CTD_human
HgenePDGFAC1458155Mammary Neoplasms1CTD_human
HgenePDGFAC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgenePDGFAC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
HgenePDGFAC3489628Thrombocytosis, Autosomal Dominant1CTD_human
HgenePDGFAC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human
HgenePDGFAC4704874Mammary Carcinoma, Human1CTD_human
HgenePDGFAC4721507Alveolitis, Fibrosing1CTD_human
TgenePRKAR1BC4751505PRKAR1B-related neurodegenerative dementia with intermediate filaments2ORPHANET