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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDHX-CD44 (FusionGDB2 ID:63467)

Fusion Gene Summary for PDHX-CD44

check button Fusion gene summary
Fusion gene informationFusion gene name: PDHX-CD44
Fusion gene ID: 63467
HgeneTgene
Gene symbol

PDHX

CD44

Gene ID

8050

960

Gene namepyruvate dehydrogenase complex component XCD44 molecule (Indian blood group)
SynonymsDLDBP|E3BP|OPDX|PDHXD|PDX1|proXCDW44|CSPG8|ECMR-III|HCELL|HUTCH-I|IN|LHR|MC56|MDU2|MDU3|MIC4|Pgp1
Cytomap

11p13

11p13

Type of geneprotein-codingprotein-coding
Descriptionpyruvate dehydrogenase protein X component, mitochondrialdihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complexlipoyl-containing pyruvate dehydrogenase complex component Xpyruvate dehydrogenase complex, E3-binding protein subuCD44 antigenGP90 lymphocyte homing/adhesion receptorHermes antigenIndian blood group antigencell surface glycoprotein CD44chondroitin sulfate proteoglycan 8epicanextracellular matrix receptor IIIhematopoietic cell E- and L-selectin ligandheparan
Modification date2020031320200329
UniProtAcc.

P16070

Ensembl transtripts involved in fusion geneENST00000448838, ENST00000227868, 
ENST00000430469, ENST00000477173, 
ENST00000263398, ENST00000526025, 
ENST00000449691, ENST00000360158, 
ENST00000415148, ENST00000437706, 
ENST00000433354, ENST00000428726, 
ENST00000526669, ENST00000433892, 
ENST00000278386, ENST00000434472, 
ENST00000352818, ENST00000528922, 
Fusion gene scores* DoF score13 X 11 X 6=85812 X 14 X 4=672
# samples 1716
** MAII scorelog2(17/858*10)=-2.33544290136184
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/672*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDHX [Title/Abstract] AND CD44 [Title/Abstract] AND fusion [Title/Abstract]

Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study (pmid: 21194677)
Most frequent breakpointCD44(35211612)-PDHX(34952950), # samples:2
CD44(35211611)-PDHX(34952950), # samples:2
PDHX(34953031)-CD44(35236399), # samples:1
Anticipated loss of major functional domain due to fusion event.CD44-PDHX seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CD44-PDHX seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CD44-PDHX seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCD44

GO:0007155

cell adhesion

19703720

TgeneCD44

GO:0016477

cell migration

22726066

TgeneCD44

GO:0030214

hyaluronan catabolic process

17170110

TgeneCD44

GO:0033138

positive regulation of peptidyl-serine phosphorylation

17045821

TgeneCD44

GO:0042110

T cell activation

7528188

TgeneCD44

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

TgeneCD44

GO:0044344

cellular response to fibroblast growth factor stimulus

19577615

TgeneCD44

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

TgeneCD44

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821

TgeneCD44

GO:1902166

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

17045821


check buttonFusion gene breakpoints across PDHX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CD44 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IN-8462-11APDHXchr11

34953031

+CD44chr11

35236399

+


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Fusion Gene ORF analysis for PDHX-CD44

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000448838ENST00000263398PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000526025PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000449691PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000360158PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000415148PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000437706PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000433354PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000428726PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000526669PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000433892PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000278386PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000434472PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000352818PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000448838ENST00000528922PDHXchr11

34953031

+CD44chr11

35236399

+
In-frameENST00000227868ENST00000263398PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000526025PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000449691PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000360158PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000415148PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000437706PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000433354PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000428726PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000526669PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000433892PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000278386PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000434472PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000352818PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000227868ENST00000528922PDHXchr11

34953031

+CD44chr11

35236399

+
In-frameENST00000430469ENST00000263398PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000526025PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000449691PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000360158PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000415148PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000437706PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000433354PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000428726PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000526669PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000433892PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000278386PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000434472PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000352818PDHXchr11

34953031

+CD44chr11

35236399

+
5CDS-intronENST00000430469ENST00000528922PDHXchr11

34953031

+CD44chr11

35236399

+
intron-3CDSENST00000477173ENST00000263398PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000526025PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000449691PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000360158PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000415148PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000437706PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000433354PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000428726PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000526669PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000433892PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000278386PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000434472PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000352818PDHXchr11

34953031

+CD44chr11

35236399

+
intron-intronENST00000477173ENST00000528922PDHXchr11

34953031

+CD44chr11

35236399

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448838PDHXchr1134953031+ENST00000263398CD44chr1135236399+392643898856252
ENST00000227868PDHXchr1134953031+ENST00000263398CD44chr1135236399+381332554743229
ENST00000430469PDHXchr1134953031+ENST00000263398CD44chr1135236399+375326524683219

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448838ENST00000263398PDHXchr1134953031+CD44chr1135236399+0.0057949940.99420506
ENST00000227868ENST00000263398PDHXchr1134953031+CD44chr1135236399+0.0348532760.9651468
ENST00000430469ENST00000263398PDHXchr1134953031+CD44chr1135236399+0.0364175180.96358246

Top

Fusion Genomic Features for PDHX-CD44


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PDHXchr1134953031+CD44chr1135236398+3.63E-060.9999964
PDHXchr1134953031+CD44chr1135236398+3.63E-060.9999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PDHX-CD44


check button Go to

FGviewer for the breakpoints of chr11:34953031-chr11:35236399

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CD44

P16070

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCD44chr11:34953031chr11:35236399ENST0000027838604150_1580140.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneCD44chr11:34953031chr11:35236399ENST0000035281808150_1580.0341.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneCD44chr11:34953031chr11:35236399ENST000002783860432_1200140.0DomainLink
TgeneCD44chr11:34953031chr11:35236399ENST000003528180832_1200.0341.0DomainLink
TgeneCD44chr11:34953031chr11:35236399ENST0000026339849224_649222.33333333333334362.0RegionNote=Stem
TgeneCD44chr11:34953031chr11:35236399ENST0000027838604224_6490140.0RegionNote=Stem
TgeneCD44chr11:34953031chr11:35236399ENST0000035281808224_6490.0341.0RegionNote=Stem
TgeneCD44chr11:34953031chr11:35236399ENST0000026339849671_742222.33333333333334362.0Topological domainCytoplasmic
TgeneCD44chr11:34953031chr11:35236399ENST000002783860421_6490140.0Topological domainExtracellular
TgeneCD44chr11:34953031chr11:35236399ENST0000027838604671_7420140.0Topological domainCytoplasmic
TgeneCD44chr11:34953031chr11:35236399ENST000003528180821_6490.0341.0Topological domainExtracellular
TgeneCD44chr11:34953031chr11:35236399ENST0000035281808671_7420.0341.0Topological domainCytoplasmic
TgeneCD44chr11:34953031chr11:35236399ENST00000360158510671_742257.3333333333333397.0Topological domainCytoplasmic
TgeneCD44chr11:34953031chr11:35236399ENST000004151481217671_742560.3333333333334700.0Topological domainCytoplasmic
TgeneCD44chr11:34953031chr11:35236399ENST000004287261318671_742603.3333333333334743.0Topological domainCytoplasmic
TgeneCD44chr11:34953031chr11:35236399ENST00000433892712671_742354.3333333333333494.0Topological domainCytoplasmic
TgeneCD44chr11:34953031chr11:35236399ENST00000434472510671_742290.3333333333333430.0Topological domainCytoplasmic
TgeneCD44chr11:34953031chr11:35236399ENST000004377061217671_742535.3333333333334675.0Topological domainCytoplasmic
TgeneCD44chr11:34953031chr11:35236399ENST000004496911217671_742560.3333333333334700.0Topological domainCytoplasmic
TgeneCD44chr11:34953031chr11:35236399ENST0000026339849650_670222.33333333333334362.0TransmembraneHelical
TgeneCD44chr11:34953031chr11:35236399ENST0000027838604650_6700140.0TransmembraneHelical
TgeneCD44chr11:34953031chr11:35236399ENST0000035281808650_6700.0341.0TransmembraneHelical
TgeneCD44chr11:34953031chr11:35236399ENST00000360158510650_670257.3333333333333397.0TransmembraneHelical
TgeneCD44chr11:34953031chr11:35236399ENST000004151481217650_670560.3333333333334700.0TransmembraneHelical
TgeneCD44chr11:34953031chr11:35236399ENST000004287261318650_670603.3333333333334743.0TransmembraneHelical
TgeneCD44chr11:34953031chr11:35236399ENST00000433892712650_670354.3333333333333494.0TransmembraneHelical
TgeneCD44chr11:34953031chr11:35236399ENST00000434472510650_670290.3333333333333430.0TransmembraneHelical
TgeneCD44chr11:34953031chr11:35236399ENST000004377061217650_670535.3333333333334675.0TransmembraneHelical
TgeneCD44chr11:34953031chr11:35236399ENST000004496911217650_670560.3333333333334700.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDHXchr11:34953031chr11:35236399ENST00000227868+211149_17080.33333333333333502.0Compositional biasNote=Pro-rich
HgenePDHXchr11:34953031chr11:35236399ENST00000430469+26149_17080.33333333333333275.0Compositional biasNote=Pro-rich
HgenePDHXchr11:34953031chr11:35236399ENST00000227868+211183_22080.33333333333333502.0DomainPeripheral subunit-binding (PSBD)
HgenePDHXchr11:34953031chr11:35236399ENST00000227868+21156_13280.33333333333333502.0DomainLipoyl-binding
HgenePDHXchr11:34953031chr11:35236399ENST00000430469+26183_22080.33333333333333275.0DomainPeripheral subunit-binding (PSBD)
HgenePDHXchr11:34953031chr11:35236399ENST00000430469+2656_13280.33333333333333275.0DomainLipoyl-binding
TgeneCD44chr11:34953031chr11:35236399ENST0000026339849150_158222.33333333333334362.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneCD44chr11:34953031chr11:35236399ENST00000360158510150_158257.3333333333333397.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneCD44chr11:34953031chr11:35236399ENST000004151481217150_158560.3333333333334700.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneCD44chr11:34953031chr11:35236399ENST000004287261318150_158603.3333333333334743.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneCD44chr11:34953031chr11:35236399ENST00000433892712150_158354.3333333333333494.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneCD44chr11:34953031chr11:35236399ENST00000434472510150_158290.3333333333333430.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneCD44chr11:34953031chr11:35236399ENST000004377061217150_158535.3333333333334675.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneCD44chr11:34953031chr11:35236399ENST000004496911217150_158560.3333333333334700.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneCD44chr11:34953031chr11:35236399ENST000002633984932_120222.33333333333334362.0DomainLink
TgeneCD44chr11:34953031chr11:35236399ENST0000036015851032_120257.3333333333333397.0DomainLink
TgeneCD44chr11:34953031chr11:35236399ENST00000415148121732_120560.3333333333334700.0DomainLink
TgeneCD44chr11:34953031chr11:35236399ENST00000428726131832_120603.3333333333334743.0DomainLink
TgeneCD44chr11:34953031chr11:35236399ENST0000043389271232_120354.3333333333333494.0DomainLink
TgeneCD44chr11:34953031chr11:35236399ENST0000043447251032_120290.3333333333333430.0DomainLink
TgeneCD44chr11:34953031chr11:35236399ENST00000437706121732_120535.3333333333334675.0DomainLink
TgeneCD44chr11:34953031chr11:35236399ENST00000449691121732_120560.3333333333334700.0DomainLink
TgeneCD44chr11:34953031chr11:35236399ENST00000360158510224_649257.3333333333333397.0RegionNote=Stem
TgeneCD44chr11:34953031chr11:35236399ENST000004151481217224_649560.3333333333334700.0RegionNote=Stem
TgeneCD44chr11:34953031chr11:35236399ENST000004287261318224_649603.3333333333334743.0RegionNote=Stem
TgeneCD44chr11:34953031chr11:35236399ENST00000433892712224_649354.3333333333333494.0RegionNote=Stem
TgeneCD44chr11:34953031chr11:35236399ENST00000434472510224_649290.3333333333333430.0RegionNote=Stem
TgeneCD44chr11:34953031chr11:35236399ENST000004377061217224_649535.3333333333334675.0RegionNote=Stem
TgeneCD44chr11:34953031chr11:35236399ENST000004496911217224_649560.3333333333334700.0RegionNote=Stem
TgeneCD44chr11:34953031chr11:35236399ENST000002633984921_649222.33333333333334362.0Topological domainExtracellular
TgeneCD44chr11:34953031chr11:35236399ENST0000036015851021_649257.3333333333333397.0Topological domainExtracellular
TgeneCD44chr11:34953031chr11:35236399ENST00000415148121721_649560.3333333333334700.0Topological domainExtracellular
TgeneCD44chr11:34953031chr11:35236399ENST00000428726131821_649603.3333333333334743.0Topological domainExtracellular
TgeneCD44chr11:34953031chr11:35236399ENST0000043389271221_649354.3333333333333494.0Topological domainExtracellular
TgeneCD44chr11:34953031chr11:35236399ENST0000043447251021_649290.3333333333333430.0Topological domainExtracellular
TgeneCD44chr11:34953031chr11:35236399ENST00000437706121721_649535.3333333333334675.0Topological domainExtracellular
TgeneCD44chr11:34953031chr11:35236399ENST00000449691121721_649560.3333333333334700.0Topological domainExtracellular


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Fusion Gene Sequence for PDHX-CD44


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000448838_ENST00000263398_TCGA-IN-8462-11A_PDHX_chr11_34953031_+_CD44_chr11_35236399_length(transcript)=3926nt_BP=438nt
AAACGCCCGGCCCGCTACCCTGCGCCCAGCTCCAGCCGCCGGGTCCCGCCTGGGCCTCTCCTCCTGGGAATACCGGGCACCGGTGGCCCC
GCCCCTACCTGCGCGCCGCATCTCCGGGAACAACAGTCTCCCTCCCGAGCATCACAGCCAGACATGGCCCAGACCAGGGACCCGCGCGGC
CTCCAATCTCCGCACGGCTTTGCGCGCGGCGCTTAGCCTGGGATACGGCAGCGAGGCCGCAAATGCAATCAGGCGGCGCTGAGGGCAGCC
CGGGGGCGGGGCGAACGGGGCGGGGGCCGGGGTCTGGTAAGGCCCCGCCGGCTGAGATATCCAGCGGCGCACCTGACTTCCCGGGAGGTG
ATCCCATTAAGATACTAATGCCATCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAAGGAGACCAAGACA
CATTCCACCCCAGTGGGGGGTCCCATACCACTCATGGATCTGAATCAGATGGACACTCACATGGGAGTCAAGAAGGTGGAGCAAACACAA
CCTCTGGTCCTATAAGGACACCCCAAATTCCAGAATGGCTGATCATCTTGGCATCCCTCTTGGCCTTGGCTTTGATTCTTGCAGTTTGCA
TTGCAGTCAACAGTCGAAGAAGGTGTGGGCAGAAGAAAAAGCTAGTGATCAACAGTGGCAATGGAGCTGTGGAGGACAGAAAGCCAAGTG
GACTCAACGGAGAGGCCAGCAAGTCTCAGGAAATGGTGCATTTGGTGAACAAGGAGTCGTCAGAAACTCCAGACCAGTTTATGACAGCTG
ATGAGACAAGGAACCTGCAGAATGTGGACATGAAGATTGGGGTGTAACACCTACACCATTATCTTGGAAAGAAACAACCGTTGGAAACAT
AACCATTACAGGGAGCTGGGACACTTAACAGATGCAATGTGCTACTGATTGTTTCATTGCGAATCTTTTTTAGCATAAAATTTTCTACTC
TTTTTGTTTTTTGTGTTTTGTTCTTTAAAGTCAGGTCCAATTTGTAAAAACAGCATTGCTTTCTGAAATTAGGGCCCAATTAATAATCAG
CAAGAATTTGATCGTTCCAGTTCCCACTTGGAGGCCTTTCATCCCTCGGGTGTGCTATGGATGGCTTCTAACAAAAACTACACATATGTA
TTCCTGATCGCCAACCTTTCCCCCACCAGCTAAGGACATTTCCCAGGGTTAATAGGGCCTGGTCCCTGGGAGGAAATTTGAATGGGTCCA
TTTTGCCCTTCCATAGCCTAATCCCTGGGCATTGCTTTCCACTGAGGTTGGGGGTTGGGGTGTACTAGTTACACATCTTCAACAGACCCC
CTCTAGAAATTTTTCAGATGCTTCTGGGAGACACCCAAAGGGTGAAGCTATTTATCTGTAGTAAACTATTTATCTGTGTTTTTGAAATAT
TAAACCCTGGATCAGTCCTTTGATCAGTATAATTTTTTAAAGTTACTTTGTCAGAGGCACAAAAGGGTTTAAACTGATTCATAATAAATA
TCTGTACTTCTTCGATCTTCACCTTTTGTGCTGTGATTCTTCAGTTTCTAAACCAGCACTGTCTGGGTCCCTACAATGTATCAGGAAGAG
CTGAGAATGGTAAGGAGACTCTTCTAAGTCTTCATCTCAGAGACCCTGAGTTCCCACTCAGACCCACTCAGCCAAATCTCATGGAAGACC
AAGGAGGGCAGCACTGTTTTTGTTTTTTGTTTTTTGTTTTTTTTTTTTGACACTGTCCAAAGGTTTTCCATCCTGTCCTGGAATCAGAGT
TGGAAGCTGAGGAGCTTCAGCCTCTTTTATGGTTTAATGGCCACCTGTTCTCTCCTGTGAAAGGCTTTGCAAAGTCACATTAAGTTTGCA
TGACCTGTTATCCCTGGGGCCCTATTTCATAGAGGCTGGCCCTATTAGTGATTTCCAAAAACAATATGGAAGTGCCTTTTGATGTCTTAC
AATAAGAGAAGAAGCCAATGGAAATGAAAGAGATTGGCAAAGGGGAAGGATGATGCCATGTAGATCCTGTTTGACATTTTTATGGCTGTA
TTTGTAAACTTAAACACACCAGTGTCTGTTCTTGATGCAGTTGCTATTTAGGATGAGTTAAGTGCCTGGGGAGTCCCTCAAAAGGTTAAA
GGGATTCCCATCATTGGAATCTTATCACCAGATAGGCAAGTTTATGACCAAACAAGAGAGTACTGGCTTTATCCTCTAACCTCATATTTT
CTCCCACTTGGCAAGTCCTTTGTGGCATTTATTCATCAGTCAGGGTGTCCGATTGGTCCTAGAACTTCCAAAGGCTGCTTGTCATAGAAG
CCATTGCATCTATAAAGCAACGGCTCCTGTTAAATGGTATCTCCTTTCTGAGGCTCCTACTAAAAGTCATTTGTTACCTAAACTTATGTG
CTTAACAGGCAATGCTTCTCAGACCACAAAGCAGAAAGAAGAAGAAAAGCTCCTGACTAAATCAGGGCTGGGCTTAGACAGAGTTGATCT
GTAGAATATCTTTAAAGGAGAGATGTCAACTTTCTGCACTATTCCCAGCCTCTGCTCCTCCCTGTCTACCCTCTCCCCTCCCTCTCTCCC
TCCACTTCACCCCACAATCTTGAAAAACTTCCTTTCTCTTCTGTGAACATCATTGGCCAGATCCATTTTCAGTGGTCTGGATTTCTTTTT
ATTTTCTTTTCAACTTGAAAGAAACTGGACATTAGGCCACTATGTGTTGTTACTGCCACTAGTGTTCAAGTGCCTCTTGTTTTCCCAGAG
ATTTCCTGGGTCTGCCAGAGGCCCAGACAGGCTCACTCAAGCTCTTTAACTGAAAAGCAACAAGCCACTCCAGGACAAGGTTCAAAATGG
TTACAACAGCCTCTACCTGTCGCCCCAGGGAGAAAGGGGTAGTGATACAAGTCTCATAGCCAGAGATGGTTTTCCACTCCTTCTAGATAT
TCCCAAAAAGAGGCTGAGACAGGAGGTTATTTTCAATTTTATTTTGGAATTAAATACTTTTTTCCCTTTATTACTGTTGTAGTCCCTCAC
TTGGATATACCTCTGTTTTCACGATAGAAATAAGGGAGGTCTAGAGCTTCTATTCCTTGGCCATTGTCAACGGAGAGCTGGCCAAGTCTT
CACAAACCCTTGCAACATTGCCTGAAGTTTATGGAATAAGATGTATTCTCACTCCCTTGATCTCAAGGGCGTAACTCTGGAAGCACAGCT
TGACTACACGTCATTTTTACCAATGATTTTCAGGTGACCTGGGCTAAGTCATTTAAACTGGGTCTTTATAAAAGTAAAAGGCCAACATTT
AATTATTTTGCAAAGCAACCTAAGAGCTAAAGATGTAATTTTTCTTGCAATTGTAAATCTTTTGTGTCTCCTGAAGACTTCCCTTAAAAT
TAGCTCTGAGTGAAAAATCAAAAGAGACAAAAGACATCTTCGAATCCATATTTCAAGCCTGGTAGAATTGGCTTTTCTAGCAGAACCTTT
CCAAAAGTTTTATATTGAGATTCATAACAACACCAAGAATTGATTTTGTAGCCAACATTCATTCAATACTGTTATATCAGAGGAGTAGGA
GAGAGGAAACATTTGACTTATCTGGAAAAGCAAAATGTACTTAAGAATAAGAATAACATGGTCCATTCACCTTTATGTTATAGATATGTC
TTTGTGTAAATCATTTGTTTTGAGTTTTCAAAGAATAGCCCATTGTTCATTCTTGTGCTGTACAATGACCACTGTTATTGTTACTTTGAC
TTTTCAGAGCACACCCTTCCTCTGGTTTTTGTATATTTATTGATGGATCAATAATAATGAGGAAAGCATGATATGTATATTGCTGAGTTG

>In-frame_ENST00000448838_ENST00000263398_TCGA-IN-8462-11A_PDHX_chr11_34953031_+_CD44_chr11_35236399_length(amino acids)=252AA_start in transcript=98_stop in transcript=856
MRAASPGTTVSLPSITARHGPDQGPARPPISARLCARRLAWDTAARPQMQSGGAEGSPGAGRTGRGPGSGKAPPAEISSGAPDFPGGDPI
KILMPSLSPTMEEGNIVKWLKKEGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAV

--------------------------------------------------------------
>In-frame_ENST00000227868_ENST00000263398_TCGA-IN-8462-11A_PDHX_chr11_34953031_+_CD44_chr11_35236399_length(transcript)=3813nt_BP=325nt
GGGCGTGGCCAACCATGCGGGAGGCGGGGCCTTGATGCTGGACATCAGGCTGTGCTGCGGGCAGCCAGTGAGAAGGCCGTCAAGATGGCG
GCCTCCTGGAGGCTGGGCTGTGATCCGCGGCTGCTGCGTTATCTTGTGGGCTTCCCCGGCCGCCGAAGCGTAGGGCTGGTGAAGGGGGCT
CTTGGGTGGTCTGTAAGCCGCGGAGCTAATTGGAGATGGTTTCACAGCACGCAGTGGCTTCGGGGTGATCCCATTAAGATACTAATGCCA
TCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAAGGAGACCAAGACACATTCCACCCCAGTGGGGGGTCC
CATACCACTCATGGATCTGAATCAGATGGACACTCACATGGGAGTCAAGAAGGTGGAGCAAACACAACCTCTGGTCCTATAAGGACACCC
CAAATTCCAGAATGGCTGATCATCTTGGCATCCCTCTTGGCCTTGGCTTTGATTCTTGCAGTTTGCATTGCAGTCAACAGTCGAAGAAGG
TGTGGGCAGAAGAAAAAGCTAGTGATCAACAGTGGCAATGGAGCTGTGGAGGACAGAAAGCCAAGTGGACTCAACGGAGAGGCCAGCAAG
TCTCAGGAAATGGTGCATTTGGTGAACAAGGAGTCGTCAGAAACTCCAGACCAGTTTATGACAGCTGATGAGACAAGGAACCTGCAGAAT
GTGGACATGAAGATTGGGGTGTAACACCTACACCATTATCTTGGAAAGAAACAACCGTTGGAAACATAACCATTACAGGGAGCTGGGACA
CTTAACAGATGCAATGTGCTACTGATTGTTTCATTGCGAATCTTTTTTAGCATAAAATTTTCTACTCTTTTTGTTTTTTGTGTTTTGTTC
TTTAAAGTCAGGTCCAATTTGTAAAAACAGCATTGCTTTCTGAAATTAGGGCCCAATTAATAATCAGCAAGAATTTGATCGTTCCAGTTC
CCACTTGGAGGCCTTTCATCCCTCGGGTGTGCTATGGATGGCTTCTAACAAAAACTACACATATGTATTCCTGATCGCCAACCTTTCCCC
CACCAGCTAAGGACATTTCCCAGGGTTAATAGGGCCTGGTCCCTGGGAGGAAATTTGAATGGGTCCATTTTGCCCTTCCATAGCCTAATC
CCTGGGCATTGCTTTCCACTGAGGTTGGGGGTTGGGGTGTACTAGTTACACATCTTCAACAGACCCCCTCTAGAAATTTTTCAGATGCTT
CTGGGAGACACCCAAAGGGTGAAGCTATTTATCTGTAGTAAACTATTTATCTGTGTTTTTGAAATATTAAACCCTGGATCAGTCCTTTGA
TCAGTATAATTTTTTAAAGTTACTTTGTCAGAGGCACAAAAGGGTTTAAACTGATTCATAATAAATATCTGTACTTCTTCGATCTTCACC
TTTTGTGCTGTGATTCTTCAGTTTCTAAACCAGCACTGTCTGGGTCCCTACAATGTATCAGGAAGAGCTGAGAATGGTAAGGAGACTCTT
CTAAGTCTTCATCTCAGAGACCCTGAGTTCCCACTCAGACCCACTCAGCCAAATCTCATGGAAGACCAAGGAGGGCAGCACTGTTTTTGT
TTTTTGTTTTTTGTTTTTTTTTTTTGACACTGTCCAAAGGTTTTCCATCCTGTCCTGGAATCAGAGTTGGAAGCTGAGGAGCTTCAGCCT
CTTTTATGGTTTAATGGCCACCTGTTCTCTCCTGTGAAAGGCTTTGCAAAGTCACATTAAGTTTGCATGACCTGTTATCCCTGGGGCCCT
ATTTCATAGAGGCTGGCCCTATTAGTGATTTCCAAAAACAATATGGAAGTGCCTTTTGATGTCTTACAATAAGAGAAGAAGCCAATGGAA
ATGAAAGAGATTGGCAAAGGGGAAGGATGATGCCATGTAGATCCTGTTTGACATTTTTATGGCTGTATTTGTAAACTTAAACACACCAGT
GTCTGTTCTTGATGCAGTTGCTATTTAGGATGAGTTAAGTGCCTGGGGAGTCCCTCAAAAGGTTAAAGGGATTCCCATCATTGGAATCTT
ATCACCAGATAGGCAAGTTTATGACCAAACAAGAGAGTACTGGCTTTATCCTCTAACCTCATATTTTCTCCCACTTGGCAAGTCCTTTGT
GGCATTTATTCATCAGTCAGGGTGTCCGATTGGTCCTAGAACTTCCAAAGGCTGCTTGTCATAGAAGCCATTGCATCTATAAAGCAACGG
CTCCTGTTAAATGGTATCTCCTTTCTGAGGCTCCTACTAAAAGTCATTTGTTACCTAAACTTATGTGCTTAACAGGCAATGCTTCTCAGA
CCACAAAGCAGAAAGAAGAAGAAAAGCTCCTGACTAAATCAGGGCTGGGCTTAGACAGAGTTGATCTGTAGAATATCTTTAAAGGAGAGA
TGTCAACTTTCTGCACTATTCCCAGCCTCTGCTCCTCCCTGTCTACCCTCTCCCCTCCCTCTCTCCCTCCACTTCACCCCACAATCTTGA
AAAACTTCCTTTCTCTTCTGTGAACATCATTGGCCAGATCCATTTTCAGTGGTCTGGATTTCTTTTTATTTTCTTTTCAACTTGAAAGAA
ACTGGACATTAGGCCACTATGTGTTGTTACTGCCACTAGTGTTCAAGTGCCTCTTGTTTTCCCAGAGATTTCCTGGGTCTGCCAGAGGCC
CAGACAGGCTCACTCAAGCTCTTTAACTGAAAAGCAACAAGCCACTCCAGGACAAGGTTCAAAATGGTTACAACAGCCTCTACCTGTCGC
CCCAGGGAGAAAGGGGTAGTGATACAAGTCTCATAGCCAGAGATGGTTTTCCACTCCTTCTAGATATTCCCAAAAAGAGGCTGAGACAGG
AGGTTATTTTCAATTTTATTTTGGAATTAAATACTTTTTTCCCTTTATTACTGTTGTAGTCCCTCACTTGGATATACCTCTGTTTTCACG
ATAGAAATAAGGGAGGTCTAGAGCTTCTATTCCTTGGCCATTGTCAACGGAGAGCTGGCCAAGTCTTCACAAACCCTTGCAACATTGCCT
GAAGTTTATGGAATAAGATGTATTCTCACTCCCTTGATCTCAAGGGCGTAACTCTGGAAGCACAGCTTGACTACACGTCATTTTTACCAA
TGATTTTCAGGTGACCTGGGCTAAGTCATTTAAACTGGGTCTTTATAAAAGTAAAAGGCCAACATTTAATTATTTTGCAAAGCAACCTAA
GAGCTAAAGATGTAATTTTTCTTGCAATTGTAAATCTTTTGTGTCTCCTGAAGACTTCCCTTAAAATTAGCTCTGAGTGAAAAATCAAAA
GAGACAAAAGACATCTTCGAATCCATATTTCAAGCCTGGTAGAATTGGCTTTTCTAGCAGAACCTTTCCAAAAGTTTTATATTGAGATTC
ATAACAACACCAAGAATTGATTTTGTAGCCAACATTCATTCAATACTGTTATATCAGAGGAGTAGGAGAGAGGAAACATTTGACTTATCT
GGAAAAGCAAAATGTACTTAAGAATAAGAATAACATGGTCCATTCACCTTTATGTTATAGATATGTCTTTGTGTAAATCATTTGTTTTGA
GTTTTCAAAGAATAGCCCATTGTTCATTCTTGTGCTGTACAATGACCACTGTTATTGTTACTTTGACTTTTCAGAGCACACCCTTCCTCT
GGTTTTTGTATATTTATTGATGGATCAATAATAATGAGGAAAGCATGATATGTATATTGCTGAGTTGAAAGCACTTATTGGAAAATATTA

>In-frame_ENST00000227868_ENST00000263398_TCGA-IN-8462-11A_PDHX_chr11_34953031_+_CD44_chr11_35236399_length(amino acids)=229AA_start in transcript=54_stop in transcript=743
MRAASEKAVKMAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKILMPSLSPTMEEGNIVKWLKKE
GDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVED

--------------------------------------------------------------
>In-frame_ENST00000430469_ENST00000263398_TCGA-IN-8462-11A_PDHX_chr11_34953031_+_CD44_chr11_35236399_length(transcript)=3753nt_BP=265nt
GCAGCCAGTGAGAAGGCCGTCAAGATGGCGGCCTCCTGGAGGCTGGGCTGTGATCCGCGGCTGCTGCGTTATCTTGTGGGCTTCCCCGGC
CGCCGAAGCGTAGGGCTGGTGAAGGGGGCTCTTGGGTGGTCTGTAAGCCGCGGAGCTAATTGGAGATGGTTTCACAGCACGCAGTGGCTT
CGGGGTGATCCCATTAAGATACTAATGCCATCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAAGGAGAC
CAAGACACATTCCACCCCAGTGGGGGGTCCCATACCACTCATGGATCTGAATCAGATGGACACTCACATGGGAGTCAAGAAGGTGGAGCA
AACACAACCTCTGGTCCTATAAGGACACCCCAAATTCCAGAATGGCTGATCATCTTGGCATCCCTCTTGGCCTTGGCTTTGATTCTTGCA
GTTTGCATTGCAGTCAACAGTCGAAGAAGGTGTGGGCAGAAGAAAAAGCTAGTGATCAACAGTGGCAATGGAGCTGTGGAGGACAGAAAG
CCAAGTGGACTCAACGGAGAGGCCAGCAAGTCTCAGGAAATGGTGCATTTGGTGAACAAGGAGTCGTCAGAAACTCCAGACCAGTTTATG
ACAGCTGATGAGACAAGGAACCTGCAGAATGTGGACATGAAGATTGGGGTGTAACACCTACACCATTATCTTGGAAAGAAACAACCGTTG
GAAACATAACCATTACAGGGAGCTGGGACACTTAACAGATGCAATGTGCTACTGATTGTTTCATTGCGAATCTTTTTTAGCATAAAATTT
TCTACTCTTTTTGTTTTTTGTGTTTTGTTCTTTAAAGTCAGGTCCAATTTGTAAAAACAGCATTGCTTTCTGAAATTAGGGCCCAATTAA
TAATCAGCAAGAATTTGATCGTTCCAGTTCCCACTTGGAGGCCTTTCATCCCTCGGGTGTGCTATGGATGGCTTCTAACAAAAACTACAC
ATATGTATTCCTGATCGCCAACCTTTCCCCCACCAGCTAAGGACATTTCCCAGGGTTAATAGGGCCTGGTCCCTGGGAGGAAATTTGAAT
GGGTCCATTTTGCCCTTCCATAGCCTAATCCCTGGGCATTGCTTTCCACTGAGGTTGGGGGTTGGGGTGTACTAGTTACACATCTTCAAC
AGACCCCCTCTAGAAATTTTTCAGATGCTTCTGGGAGACACCCAAAGGGTGAAGCTATTTATCTGTAGTAAACTATTTATCTGTGTTTTT
GAAATATTAAACCCTGGATCAGTCCTTTGATCAGTATAATTTTTTAAAGTTACTTTGTCAGAGGCACAAAAGGGTTTAAACTGATTCATA
ATAAATATCTGTACTTCTTCGATCTTCACCTTTTGTGCTGTGATTCTTCAGTTTCTAAACCAGCACTGTCTGGGTCCCTACAATGTATCA
GGAAGAGCTGAGAATGGTAAGGAGACTCTTCTAAGTCTTCATCTCAGAGACCCTGAGTTCCCACTCAGACCCACTCAGCCAAATCTCATG
GAAGACCAAGGAGGGCAGCACTGTTTTTGTTTTTTGTTTTTTGTTTTTTTTTTTTGACACTGTCCAAAGGTTTTCCATCCTGTCCTGGAA
TCAGAGTTGGAAGCTGAGGAGCTTCAGCCTCTTTTATGGTTTAATGGCCACCTGTTCTCTCCTGTGAAAGGCTTTGCAAAGTCACATTAA
GTTTGCATGACCTGTTATCCCTGGGGCCCTATTTCATAGAGGCTGGCCCTATTAGTGATTTCCAAAAACAATATGGAAGTGCCTTTTGAT
GTCTTACAATAAGAGAAGAAGCCAATGGAAATGAAAGAGATTGGCAAAGGGGAAGGATGATGCCATGTAGATCCTGTTTGACATTTTTAT
GGCTGTATTTGTAAACTTAAACACACCAGTGTCTGTTCTTGATGCAGTTGCTATTTAGGATGAGTTAAGTGCCTGGGGAGTCCCTCAAAA
GGTTAAAGGGATTCCCATCATTGGAATCTTATCACCAGATAGGCAAGTTTATGACCAAACAAGAGAGTACTGGCTTTATCCTCTAACCTC
ATATTTTCTCCCACTTGGCAAGTCCTTTGTGGCATTTATTCATCAGTCAGGGTGTCCGATTGGTCCTAGAACTTCCAAAGGCTGCTTGTC
ATAGAAGCCATTGCATCTATAAAGCAACGGCTCCTGTTAAATGGTATCTCCTTTCTGAGGCTCCTACTAAAAGTCATTTGTTACCTAAAC
TTATGTGCTTAACAGGCAATGCTTCTCAGACCACAAAGCAGAAAGAAGAAGAAAAGCTCCTGACTAAATCAGGGCTGGGCTTAGACAGAG
TTGATCTGTAGAATATCTTTAAAGGAGAGATGTCAACTTTCTGCACTATTCCCAGCCTCTGCTCCTCCCTGTCTACCCTCTCCCCTCCCT
CTCTCCCTCCACTTCACCCCACAATCTTGAAAAACTTCCTTTCTCTTCTGTGAACATCATTGGCCAGATCCATTTTCAGTGGTCTGGATT
TCTTTTTATTTTCTTTTCAACTTGAAAGAAACTGGACATTAGGCCACTATGTGTTGTTACTGCCACTAGTGTTCAAGTGCCTCTTGTTTT
CCCAGAGATTTCCTGGGTCTGCCAGAGGCCCAGACAGGCTCACTCAAGCTCTTTAACTGAAAAGCAACAAGCCACTCCAGGACAAGGTTC
AAAATGGTTACAACAGCCTCTACCTGTCGCCCCAGGGAGAAAGGGGTAGTGATACAAGTCTCATAGCCAGAGATGGTTTTCCACTCCTTC
TAGATATTCCCAAAAAGAGGCTGAGACAGGAGGTTATTTTCAATTTTATTTTGGAATTAAATACTTTTTTCCCTTTATTACTGTTGTAGT
CCCTCACTTGGATATACCTCTGTTTTCACGATAGAAATAAGGGAGGTCTAGAGCTTCTATTCCTTGGCCATTGTCAACGGAGAGCTGGCC
AAGTCTTCACAAACCCTTGCAACATTGCCTGAAGTTTATGGAATAAGATGTATTCTCACTCCCTTGATCTCAAGGGCGTAACTCTGGAAG
CACAGCTTGACTACACGTCATTTTTACCAATGATTTTCAGGTGACCTGGGCTAAGTCATTTAAACTGGGTCTTTATAAAAGTAAAAGGCC
AACATTTAATTATTTTGCAAAGCAACCTAAGAGCTAAAGATGTAATTTTTCTTGCAATTGTAAATCTTTTGTGTCTCCTGAAGACTTCCC
TTAAAATTAGCTCTGAGTGAAAAATCAAAAGAGACAAAAGACATCTTCGAATCCATATTTCAAGCCTGGTAGAATTGGCTTTTCTAGCAG
AACCTTTCCAAAAGTTTTATATTGAGATTCATAACAACACCAAGAATTGATTTTGTAGCCAACATTCATTCAATACTGTTATATCAGAGG
AGTAGGAGAGAGGAAACATTTGACTTATCTGGAAAAGCAAAATGTACTTAAGAATAAGAATAACATGGTCCATTCACCTTTATGTTATAG
ATATGTCTTTGTGTAAATCATTTGTTTTGAGTTTTCAAAGAATAGCCCATTGTTCATTCTTGTGCTGTACAATGACCACTGTTATTGTTA
CTTTGACTTTTCAGAGCACACCCTTCCTCTGGTTTTTGTATATTTATTGATGGATCAATAATAATGAGGAAAGCATGATATGTATATTGC

>In-frame_ENST00000430469_ENST00000263398_TCGA-IN-8462-11A_PDHX_chr11_34953031_+_CD44_chr11_35236399_length(amino acids)=219AA_start in transcript=24_stop in transcript=683
MAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKILMPSLSPTMEEGNIVKWLKKEGDQDTFHPSG
GSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PDHX-CD44


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDHX-CD44


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCD44P16070DB08818Hyaluronic acidSmall moleculeApproved|Vet_approved
TgeneCD44P16070DB08818Hyaluronic acidSmall moleculeApproved|Vet_approved
TgeneCD44P16070DB08818Hyaluronic acidSmall moleculeApproved|Vet_approved
TgeneCD44P16070DB08818Hyaluronic acidSmall moleculeApproved|Vet_approved
TgeneCD44P16070DB08818Hyaluronic acidSmall moleculeApproved|Vet_approved

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Related Diseases for PDHX-CD44


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDHXC1855553Pyruvate Dehydrogenase E3-Binding Protein Deficiency3CTD_human;GENOMICS_ENGLAND;ORPHANET
HgenePDHXC0013421Dystonia1GENOMICS_ENGLAND
HgenePDHXC0020796Profound Mental Retardation1CTD_human
HgenePDHXC0025363Mental Retardation, Psychosocial1CTD_human
HgenePDHXC0917816Mental deficiency1CTD_human
HgenePDHXC3714756Intellectual Disability1CTD_human
TgeneCD44C0023487Acute Promyelocytic Leukemia2CTD_human
TgeneCD44C0009405Hereditary Nonpolyposis Colorectal Neoplasms1CTD_human
TgeneCD44C0011616Contact Dermatitis1CTD_human
TgeneCD44C0017661IGA Glomerulonephritis1CTD_human
TgeneCD44C0022660Kidney Failure, Acute1CTD_human
TgeneCD44C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneCD44C0024623Malignant neoplasm of stomach1CTD_human
TgeneCD44C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneCD44C0026998Acute Myeloid Leukemia, M11CTD_human
TgeneCD44C0027627Neoplasm Metastasis1CTD_human
TgeneCD44C0027746Nerve Degeneration1CTD_human
TgeneCD44C0030297Pancreatic Neoplasm1CTD_human
TgeneCD44C0032580Adenomatous Polyposis Coli1CTD_human
TgeneCD44C0037274Dermatologic disorders1CTD_human
TgeneCD44C0038356Stomach Neoplasms1CTD_human
TgeneCD44C0042900Vitiligo1CTD_human
TgeneCD44C0162351Contact hypersensitivity1CTD_human
TgeneCD44C0274861Arsenic Poisoning, Inorganic1CTD_human
TgeneCD44C0274862Nervous System, Organic Arsenic Poisoning1CTD_human
TgeneCD44C0311375Arsenic Poisoning1CTD_human
TgeneCD44C0346647Malignant neoplasm of pancreas1CTD_human
TgeneCD44C0751851Arsenic Encephalopathy1CTD_human
TgeneCD44C0751852Arsenic Induced Polyneuropathy1CTD_human
TgeneCD44C1333990Hereditary Nonpolyposis Colorectal Cancer1CTD_human
TgeneCD44C1565662Acute Kidney Insufficiency1CTD_human
TgeneCD44C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneCD44C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneCD44C2609414Acute kidney injury1CTD_human
TgeneCD44C2713442Polyposis, Adenomatous Intestinal1CTD_human
TgeneCD44C2713443Familial Intestinal Polyposis1CTD_human
TgeneCD44C4552100Lynch Syndrome1CTD_human