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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDLIM5-SHISA5 (FusionGDB2 ID:63599)

Fusion Gene Summary for PDLIM5-SHISA5

check button Fusion gene summary
Fusion gene informationFusion gene name: PDLIM5-SHISA5
Fusion gene ID: 63599
HgeneTgene
Gene symbol

PDLIM5

SHISA5

Gene ID

10611

51246

Gene namePDZ and LIM domain 5shisa family member 5
SynonymsENH|ENH1|L9|LIMSCOTIN
Cytomap

4q22.3

3p21.31

Type of geneprotein-codingprotein-coding
DescriptionPDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains proteinprotein shisa-5putative NF-kappa-B-activating protein 120shisa homolog 5
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000450793, ENST00000538141, 
ENST00000380180, ENST00000318007, 
ENST00000437932, ENST00000317968, 
ENST00000542407, ENST00000508216, 
ENST00000514743, ENST00000380176, 
ENST00000359265, ENST00000512274, 
ENST00000504489, 		ENST00000296444, 
ENST00000444115, ENST00000426002, 
ENST00000465449, ENST00000442747, 
ENST00000443308, 
Fusion gene scores* DoF score20 X 18 X 9=324014 X 9 X 8=1008
# samples 2315
** MAII scorelog2(23/3240*10)=-3.81628804682761
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1008*10)=-2.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDLIM5 [Title/Abstract] AND SHISA5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDLIM5(95539342)-SHISA5(48538726), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PDLIM5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SHISA5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-LL-A7T0-01APDLIM5chr4

95539342

+SHISA5chr3

48538726

-
ChimerDB4BRCATCGA-LL-A7T0-01APDLIM5chr4

95539342

+SHISA5chr3

48538726

-
ChimerDB4BRCATCGA-LL-A7T0-01APDLIM5chr4

95539342

-SHISA5chr3

48538726

-


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Fusion Gene ORF analysis for PDLIM5-SHISA5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000450793ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000450793ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000450793ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000450793ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000450793ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000450793ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000538141ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000538141ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000538141ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000538141ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000538141ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000538141ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000380180ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000380180ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000380180ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000380180ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000380180ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000380180ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000318007ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000318007ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000318007ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000318007ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000318007ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000318007ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
In-frameENST00000437932ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000437932ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000437932ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000437932ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000437932ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000437932ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
In-frameENST00000317968ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000317968ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000317968ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000317968ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000317968ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000317968ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
In-frameENST00000542407ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000542407ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000542407ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000542407ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000542407ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000542407ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000508216ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000508216ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000508216ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000508216ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000508216ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000508216ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
In-frameENST00000514743ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000514743ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000514743ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000514743ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000514743ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000514743ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
3UTR-3CDSENST00000380176ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
3UTR-5UTRENST00000380176ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
3UTR-intronENST00000380176ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
3UTR-intronENST00000380176ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
3UTR-5UTRENST00000380176ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
3UTR-5UTRENST00000380176ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000359265ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000359265ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000359265ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000359265ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000359265ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000359265ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000512274ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000512274ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000512274ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000512274ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000512274ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000512274ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000504489ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000504489ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000504489ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000504489ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000504489ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000504489ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000437932PDLIM5chr495539342+ENST00000296444SHISA5chr348538726-28889321511578475
ENST00000317968PDLIM5chr495539342+ENST00000296444SHISA5chr348538726-320012441361890584
ENST00000542407PDLIM5chr495539342+ENST00000296444SHISA5chr348538726-300710513091697462
ENST00000514743PDLIM5chr495539342+ENST00000296444SHISA5chr348538726-31951239441885613

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000437932ENST00000296444PDLIM5chr495539342+SHISA5chr348538726-0.0042053520.99579465
ENST00000317968ENST00000296444PDLIM5chr495539342+SHISA5chr348538726-0.0048880260.995112
ENST00000542407ENST00000296444PDLIM5chr495539342+SHISA5chr348538726-0.0057192270.9942808
ENST00000514743ENST00000296444PDLIM5chr495539342+SHISA5chr348538726-0.006286080.9937139

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Fusion Genomic Features for PDLIM5-SHISA5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDLIM5-SHISA5


check button Go to

FGviewer for the breakpoints of chr4:95539342-chr3:48538726

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDLIM5chr4:95539342chr3:48538726ENST00000317968+8132_85369.3333333333333597.0DomainPDZ
HgenePDLIM5chr4:95539342chr3:48538726ENST00000437932+8132_85260.3333333333333488.0DomainPDZ
TgeneSHISA5chr4:95539342chr3:48538726ENST0000029644406147_15325.333333333333332241.0Compositional biasNote=Poly-Thr
TgeneSHISA5chr4:95539342chr3:48538726ENST0000029644406158_23025.333333333333332241.0Compositional biasNote=Pro-rich
TgeneSHISA5chr4:95539342chr3:48538726ENST0000042600204147_1530138.0Compositional biasNote=Poly-Thr
TgeneSHISA5chr4:95539342chr3:48538726ENST0000042600204158_2300138.0Compositional biasNote=Pro-rich
TgeneSHISA5chr4:95539342chr3:48538726ENST0000044274706147_1530210.0Compositional biasNote=Poly-Thr
TgeneSHISA5chr4:95539342chr3:48538726ENST0000044274706158_2300210.0Compositional biasNote=Pro-rich
TgeneSHISA5chr4:95539342chr3:48538726ENST0000044411506147_1530210.0Compositional biasNote=Poly-Thr
TgeneSHISA5chr4:95539342chr3:48538726ENST0000044411506158_2300210.0Compositional biasNote=Pro-rich
TgeneSHISA5chr4:95539342chr3:48538726ENST0000029644406127_24025.333333333333332241.0Topological domainCytoplasmic
TgeneSHISA5chr4:95539342chr3:48538726ENST000002964440629_10525.333333333333332241.0Topological domainExtracellular
TgeneSHISA5chr4:95539342chr3:48538726ENST0000042600204127_2400138.0Topological domainCytoplasmic
TgeneSHISA5chr4:95539342chr3:48538726ENST000004260020429_1050138.0Topological domainExtracellular
TgeneSHISA5chr4:95539342chr3:48538726ENST0000044274706127_2400210.0Topological domainCytoplasmic
TgeneSHISA5chr4:95539342chr3:48538726ENST000004427470629_1050210.0Topological domainExtracellular
TgeneSHISA5chr4:95539342chr3:48538726ENST0000044411506127_2400210.0Topological domainCytoplasmic
TgeneSHISA5chr4:95539342chr3:48538726ENST000004441150629_1050210.0Topological domainExtracellular
TgeneSHISA5chr4:95539342chr3:48538726ENST0000029644406106_12625.333333333333332241.0TransmembraneHelical
TgeneSHISA5chr4:95539342chr3:48538726ENST0000042600204106_1260138.0TransmembraneHelical
TgeneSHISA5chr4:95539342chr3:48538726ENST0000044274706106_1260210.0TransmembraneHelical
TgeneSHISA5chr4:95539342chr3:48538726ENST0000044411506106_1260210.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDLIM5chr4:95539342chr3:48538726ENST00000317968+813418_477369.3333333333333597.0DomainLIM zinc-binding 1
HgenePDLIM5chr4:95539342chr3:48538726ENST00000317968+813477_536369.3333333333333597.0DomainLIM zinc-binding 2
HgenePDLIM5chr4:95539342chr3:48538726ENST00000317968+813536_596369.3333333333333597.0DomainLIM zinc-binding 3
HgenePDLIM5chr4:95539342chr3:48538726ENST00000318007+1102_850215.0DomainPDZ
HgenePDLIM5chr4:95539342chr3:48538726ENST00000318007+110418_4770215.0DomainLIM zinc-binding 1
HgenePDLIM5chr4:95539342chr3:48538726ENST00000318007+110477_5360215.0DomainLIM zinc-binding 2
HgenePDLIM5chr4:95539342chr3:48538726ENST00000318007+110536_5960215.0DomainLIM zinc-binding 3
HgenePDLIM5chr4:95539342chr3:48538726ENST00000359265+132_850137.0DomainPDZ
HgenePDLIM5chr4:95539342chr3:48538726ENST00000359265+13418_4770137.0DomainLIM zinc-binding 1
HgenePDLIM5chr4:95539342chr3:48538726ENST00000359265+13477_5360137.0DomainLIM zinc-binding 2
HgenePDLIM5chr4:95539342chr3:48538726ENST00000359265+13536_5960137.0DomainLIM zinc-binding 3
HgenePDLIM5chr4:95539342chr3:48538726ENST00000380180+192_850235.0DomainPDZ
HgenePDLIM5chr4:95539342chr3:48538726ENST00000380180+19418_4770235.0DomainLIM zinc-binding 1
HgenePDLIM5chr4:95539342chr3:48538726ENST00000380180+19477_5360235.0DomainLIM zinc-binding 2
HgenePDLIM5chr4:95539342chr3:48538726ENST00000380180+19536_5960235.0DomainLIM zinc-binding 3
HgenePDLIM5chr4:95539342chr3:48538726ENST00000437932+813418_477260.3333333333333488.0DomainLIM zinc-binding 1
HgenePDLIM5chr4:95539342chr3:48538726ENST00000437932+813477_536260.3333333333333488.0DomainLIM zinc-binding 2
HgenePDLIM5chr4:95539342chr3:48538726ENST00000437932+813536_596260.3333333333333488.0DomainLIM zinc-binding 3
HgenePDLIM5chr4:95539342chr3:48538726ENST00000508216+182_850235.0DomainPDZ
HgenePDLIM5chr4:95539342chr3:48538726ENST00000508216+18418_4770235.0DomainLIM zinc-binding 1
HgenePDLIM5chr4:95539342chr3:48538726ENST00000508216+18477_5360235.0DomainLIM zinc-binding 2
HgenePDLIM5chr4:95539342chr3:48538726ENST00000508216+18536_5960235.0DomainLIM zinc-binding 3


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Fusion Gene Sequence for PDLIM5-SHISA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000437932_ENST00000296444_TCGA-LL-A7T0-01A_PDLIM5_chr4_95539342_+_SHISA5_chr3_48538726_length(transcript)=2888nt_BP=932nt
AGCCAGGAGGCGGAAGTTCCCGCGGGCGGTGGGGACGGCGCCCTCACCGCGAGTCACTTGTCAGCCCTTGTCTGAGGCGGAGGCAGCCCC
GCGCCGCGCCGGACCCGAGCATATTTCATTTTCTGTCATTGGACTTTGAGCCATTAGAACCATGAGCAACTACAGTGTGTCACTGGTTGG
CCCAGCTCCTTGGGGTTTCCGGCTGCAGGGCGGTAAGGATTTCAACATGCCTCTGACAATCTCTAGTCTAAAAGATGGCGGCAAGGCAGC
CCAGGCAAATGTAAGAATAGGCGATGTGGTTCTCAGCATTGATGGAATAAATGCACAAGGAATGACTCATCTTGAAGCCCAGAATAAGAT
TAAGGGTTGTACAGGCTCTTTGAATATGACTCTGCAAAGAGCATCTGCTGCACCCAAGCCTGAGCCGGTTCCTGTTCAAAAGCCCACAGT
CACCAGCGTGTGTTCCGAGACTTCTCAGGAGCTAGCAGAGGGACAGAGAAGAGGATCCCAGGGTGACAGTAAACAGCAAAATGGCCCACC
AAGAAAACACATTGTGGAGCGCTATACAGAGTTTTATCATGTACCCACTCACAGTGATGCCAGCAAGAAGAGACTGATTGAGGATACTGA
AGACTGGCGTCCAAGGACTGGAACAACTCAGTCTCGCTCTTTCCGAATCCTTGCCCAGATCACTGGGACTGAACATTTGAAAGAATCTGA
AGCCGATAATACAAAGAAGGCAAATAACTCTCAGGAGCCTTCTCCGCAGTTGGCTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAG
CCTGGACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCTGCAGCTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAA
GTCACCAAGCTGGCAACGGCCAAACCAAGGAGCACGTGGTGAGGTGTGTATGGCTTCCCGTGGACTCAGCCTCTTCCCCGAGTCCTGTCC
AGATTTCTGCTGTGGTACCTGTGATGACCAATACTGCTGCTCTGACGTGCTGAAGAAATTTGTGTGGAGCGAGGAAAGGTGTGCTGTGCC
TGAGGCCAGCGTGCCTGCCAGTGTAGAGCCGGTGGAGCAGCTGGGCTCGGCGCTGAGGTTTCGCCCTGGCTACAACGACCCCATGTCAGG
GTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCT
TTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGT
GCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTA
CCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCA
GCCTCCTTACAACCCGGCCTACATGGATGCCCCGAAGGCGGCCCTCTGAGCATTCCCTGGCCTCTCTGGCTGCCACTTGGTTATGTTGTG
TGTGTGCGTGAGTGGTGTGCAGGCGCGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCAGGCACGGTTCCTTACGCCCCATGTGTGCT
GTGTGTGTCCTGCCTGTATATGTGGCTTCCTCTGATGCTGACAAGGTGGGGAACAATCCTTGCCAGAGTGGGCTGGGACCAGACTTTGTT
CTCTTCCTCACCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCAAAGAATGGGGTGGTGGGGGGCACCCTGTGAGGTGGCCCCTGA
GAGGTGGGGGCCTCTCCAGGGCACATCTGGAGTTCTTCTCCAGCTTACCCTAGGGTGACCAAGTAGGGCCTGTCACACCAGGGTGGCGCA
GCTTTCTGTGTGATGCAGATGTGTCCTGGTTTCGGCAGCGTAGCCAGCTGCTGCTTGAGGCCATGGCTCGTCCCCGGAGTTGGGGGTACC
CGTTGCAGAGCCAGGGACATGATGCAGGCGAAGCTTGGGATCTGGCCAAGTTGGACTTTGATCCTTTGGGCAGATGTCCCATTGCTCCCT
GGAGCCTGTCATGCCTGTTGGGGATCAGGCAGCCTCCTGATGCCAGAACACCTCAGGCAGAGCCCTACTCAGCTGTACCTGTCTGCCTGG
ACTGTCCCCTGTCCCCGCATCTCCCCTGGGACCAGCTGGAGGGCCACATGCACACACAGCCTAGCTGCCCCCAGGGAGCTCTGCTGCCCT
TGCTGGCCCTGCCCTTCCCACAGGTGAGCAGGGCTCCTGTCCACCAGCACACTCAGTTCTCTTCCCTGCAGTGTTTTCATTTTATTTTAG
CCAAACATTTTGCCTGTTTTCTGTTTCAAACATGATAGTTGATATGAGACTGAAACCCCTGGGTTGTGGAGGGAAATTGGCTCAGAGATG
GACAACCTGGCAACTGTGAGTCCCTGCTTCCCGACACCAGCCTCATGGAATATGCAACAACTCCTGTACCCCAGTCCACGGTGTTCTGGC
AGCAGGGACACCTGGGCCAATGGGCCATCTGGACCAAAGGTGGGGTGTGGGGCCCTGGATGGCAGCTCTGGCCCAGACATGAATACCTCG
TGTTCCTCCTCCCTCTATTACTGTTTCACCAGAGCTGTCTTAGCTCAAATCTGTTGTGTTTCTGAGTCTAGGGTCTGTACACTTGTTTAT
AATAAATGCAATCGTTTGGAGCTGCTGCCCCCTTTCTTCCTGGCCTCGGCTGCTGGAATTGGAATCAGGCTGTACTCTTTCCATCCATTT

>In-frame_ENST00000437932_ENST00000296444_TCGA-LL-A7T0-01A_PDLIM5_chr4_95539342_+_SHISA5_chr3_48538726_length(amino acids)=475AA_start in transcript=151_stop in transcript=1578
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKP
EPVPVQKPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQI
TGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGARGEVCMASR
GLSLFPESCPDFCCGTCDDQYCCSDVLKKFVWSEERCAVPEASVPASVEPVEQLGSALRFRPGYNDPMSGFGATLAVGLTIFVLSVVTII
ICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPGPSYQGYHTMPPQPGMPAAPYPMQYPPPYPAQPMGPPAYHETLAG

--------------------------------------------------------------
>In-frame_ENST00000317968_ENST00000296444_TCGA-LL-A7T0-01A_PDLIM5_chr4_95539342_+_SHISA5_chr3_48538726_length(transcript)=3200nt_BP=1244nt
GTTCCCGCGGGCGGTGGGGACGGCGCCCTCACCGCGAGTCACTTGTCAGCCCTTGTCTGAGGCGGAGGCAGCCCCGCGCCGCGCCGGACC
CGAGCATATTTCATTTTCTGTCATTGGACTTTGAGCCATTAGAACCATGAGCAACTACAGTGTGTCACTGGTTGGCCCAGCTCCTTGGGG
TTTCCGGCTGCAGGGCGGTAAGGATTTCAACATGCCTCTGACAATCTCTAGTCTAAAAGATGGCGGCAAGGCAGCCCAGGCAAATGTAAG
AATAGGCGATGTGGTTCTCAGCATTGATGGAATAAATGCACAAGGAATGACTCATCTTGAAGCCCAGAATAAGATTAAGGGTTGTACAGG
CTCTTTGAATATGACTCTGCAAAGAGCATCTGCTGCACCCAAGCCTGAGCCGGTTCCTGTTCAAAAGGGAGAACCTAAAGAAGTAGTTAA
ACCTGTGCCCATTACATCTCCTGCTGTGTCCAAAGTCACTTCCACAAACAACATGGCCTACAATAAGGCACCACGGCCTTTTGGTTCTGT
GTCTTCACCAAAAGTCACATCCATCCCATCACCATCGTCTGCCTTCACCCCAGCCCATGCGACCACCTCATCACATGCTTCCCCTTCACC
CGTGGCTGCCGTCACTCCTCCCCTGTTCGCTGCATCTGGACTGCATGCTAATGCCAATCTTAGTGCTGACCAGTCTCCATCTGCACTGAG
CGCTGGTAAAACTGCAGTTAATGTCCCACGGCAGCCCACAGTCACCAGCGTGTGTTCCGAGACTTCTCAGGAGCTAGCAGAGGGACAGAG
AAGAGGATCCCAGGGTGACAGTAAACAGCAAAATGGCCCACCAAGAAAACACATTGTGGAGCGCTATACAGAGTTTTATCATGTACCCAC
TCACAGTGATGCCAGCAAGAAGAGACTGATTGAGGATACTGAAGACTGGCGTCCAAGGACTGGAACAACTCAGTCTCGCTCTTTCCGAAT
CCTTGCCCAGATCACTGGGACTGAACATTTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAATAACTCTCAGGAGCCTTCTCCGCA
GTTGGCTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGC
TGCAGCTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCAAGCTGGCAACGGCCAAACCAAGGAGCACGTGGTGAGGTGTG
TATGGCTTCCCGTGGACTCAGCCTCTTCCCCGAGTCCTGTCCAGATTTCTGCTGTGGTACCTGTGATGACCAATACTGCTGCTCTGACGT
GCTGAAGAAATTTGTGTGGAGCGAGGAAAGGTGTGCTGTGCCTGAGGCCAGCGTGCCTGCCAGTGTAGAGCCGGTGGAGCAGCTGGGCTC
GGCGCTGAGGTTTCGCCCTGGCTACAACGACCCCATGTCAGGGTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGT
CGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACCACCACATC
CACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCACACCATGCC
GCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGA
GACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTACAACCCGGCCTACATGGATGCCCCGAAGGCGGCCCTCTG
AGCATTCCCTGGCCTCTCTGGCTGCCACTTGGTTATGTTGTGTGTGTGCGTGAGTGGTGTGCAGGCGCGGTTCCTTACGCCCCATGTGTG
CTGTGTGTGTCCAGGCACGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCTGCCTGTATATGTGGCTTCCTCTGATGCTGACAAGGTG
GGGAACAATCCTTGCCAGAGTGGGCTGGGACCAGACTTTGTTCTCTTCCTCACCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCA
AAGAATGGGGTGGTGGGGGGCACCCTGTGAGGTGGCCCCTGAGAGGTGGGGGCCTCTCCAGGGCACATCTGGAGTTCTTCTCCAGCTTAC
CCTAGGGTGACCAAGTAGGGCCTGTCACACCAGGGTGGCGCAGCTTTCTGTGTGATGCAGATGTGTCCTGGTTTCGGCAGCGTAGCCAGC
TGCTGCTTGAGGCCATGGCTCGTCCCCGGAGTTGGGGGTACCCGTTGCAGAGCCAGGGACATGATGCAGGCGAAGCTTGGGATCTGGCCA
AGTTGGACTTTGATCCTTTGGGCAGATGTCCCATTGCTCCCTGGAGCCTGTCATGCCTGTTGGGGATCAGGCAGCCTCCTGATGCCAGAA
CACCTCAGGCAGAGCCCTACTCAGCTGTACCTGTCTGCCTGGACTGTCCCCTGTCCCCGCATCTCCCCTGGGACCAGCTGGAGGGCCACA
TGCACACACAGCCTAGCTGCCCCCAGGGAGCTCTGCTGCCCTTGCTGGCCCTGCCCTTCCCACAGGTGAGCAGGGCTCCTGTCCACCAGC
ACACTCAGTTCTCTTCCCTGCAGTGTTTTCATTTTATTTTAGCCAAACATTTTGCCTGTTTTCTGTTTCAAACATGATAGTTGATATGAG
ACTGAAACCCCTGGGTTGTGGAGGGAAATTGGCTCAGAGATGGACAACCTGGCAACTGTGAGTCCCTGCTTCCCGACACCAGCCTCATGG
AATATGCAACAACTCCTGTACCCCAGTCCACGGTGTTCTGGCAGCAGGGACACCTGGGCCAATGGGCCATCTGGACCAAAGGTGGGGTGT
GGGGCCCTGGATGGCAGCTCTGGCCCAGACATGAATACCTCGTGTTCCTCCTCCCTCTATTACTGTTTCACCAGAGCTGTCTTAGCTCAA
ATCTGTTGTGTTTCTGAGTCTAGGGTCTGTACACTTGTTTATAATAAATGCAATCGTTTGGAGCTGCTGCCCCCTTTCTTCCTGGCCTCG

>In-frame_ENST00000317968_ENST00000296444_TCGA-LL-A7T0-01A_PDLIM5_chr4_95539342_+_SHISA5_chr3_48538726_length(amino acids)=584AA_start in transcript=136_stop in transcript=1890
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKP
EPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLH
ANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTED
WRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKS
PSWQRPNQGARGEVCMASRGLSLFPESCPDFCCGTCDDQYCCSDVLKKFVWSEERCAVPEASVPASVEPVEQLGSALRFRPGYNDPMSGF
GATLAVGLTIFVLSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPGPSYQGYHTMPPQPGMPAAPYPMQYP

--------------------------------------------------------------
>In-frame_ENST00000542407_ENST00000296444_TCGA-LL-A7T0-01A_PDLIM5_chr4_95539342_+_SHISA5_chr3_48538726_length(transcript)=3007nt_BP=1051nt
CTTGTCAGCCCTTGTCTGAGGCGGAGGCAGCCCCGCGCCGCGCCGGACCCGAGCATATTTCATTTTCTGTCATTGGACTTTGAGCCATTA
GAACCATGAGCAACTACAGTGTGTCACTGGTTGGCCCAGCTCCTTGGGGTTTCCGGCTGCAGGGCGGTAAGGATTTCAACATGCCTCTGA
CAATCTCTAGTAGCATCTGCTGCACCCAAGCCTGAGCCGGTTCCTGTTCAAAAGGGAGAACCTAAAGAAGTAGTTAAACCTGTGCCCATT
ACATCTCCTGCTGTGTCCAAAGTCACTTCCACAAACAACATGGCCTACAATAAGGCACCACGGCCTTTTGGTTCTGTGTCTTCACCAAAA
GTCACATCCATCCCATCACCATCGTCTGCCTTCACCCCAGCCCATGCGACCACCTCATCACATGCTTCCCCTTCACCCGTGGCTGCCGTC
ACTCCTCCCCTGTTCGCTGCATCTGGACTGCATGCTAATGCCAATCTTAGTGCTGACCAGTCTCCATCTGCACTGAGCGCTGGTAAAACT
GCAGTTAATGTCCCACGGCAGCCCACAGTCACCAGCGTGTGTTCCGAGACTTCTCAGGAGCTAGCAGAGGGACAGAGAAGAGGATCCCAG
GGTGACAGTAAACAGCAAAATGGCCCACCAAGAAAACACATTGTGGAGCGCTATACAGAGTTTTATCATGTACCCACTCACAGTGATGCC
AGCAAGAAGAGACTGATTGAGGATACTGAAGACTGGCGTCCAAGGACTGGAACAACTCAGTCTCGCTCTTTCCGAATCCTTGCCCAGATC
ACTGGGACTGAACATTTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAATAACTCTCAGGAGCCTTCTCCGCAGTTGGCTTCCTCG
GTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCTGCAGCTGCCTTC
AAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCAAGCTGGCAACGGCCAAACCAAGGAGCACGTGGTGAGGTGTGTATGGCTTCCCGT
GGACTCAGCCTCTTCCCCGAGTCCTGTCCAGATTTCTGCTGTGGTACCTGTGATGACCAATACTGCTGCTCTGACGTGCTGAAGAAATTT
GTGTGGAGCGAGGAAAGGTGTGCTGTGCCTGAGGCCAGCGTGCCTGCCAGTGTAGAGCCGGTGGAGCAGCTGGGCTCGGCGCTGAGGTTT
CGCCCTGGCTACAACGACCCCATGTCAGGGTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCACTATCATC
ATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCACTGTGGTG
CATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTCAGCCAGGG
ATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCCTGGCTGGA
GGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTACAACCCGGCCTACATGGATGCCCCGAAGGCGGCCCTCTGAGCATTCCCTGGC
CTCTCTGGCTGCCACTTGGTTATGTTGTGTGTGTGCGTGAGTGGTGTGCAGGCGCGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCA
GGCACGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCTGCCTGTATATGTGGCTTCCTCTGATGCTGACAAGGTGGGGAACAATCCTT
GCCAGAGTGGGCTGGGACCAGACTTTGTTCTCTTCCTCACCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCAAAGAATGGGGTGG
TGGGGGGCACCCTGTGAGGTGGCCCCTGAGAGGTGGGGGCCTCTCCAGGGCACATCTGGAGTTCTTCTCCAGCTTACCCTAGGGTGACCA
AGTAGGGCCTGTCACACCAGGGTGGCGCAGCTTTCTGTGTGATGCAGATGTGTCCTGGTTTCGGCAGCGTAGCCAGCTGCTGCTTGAGGC
CATGGCTCGTCCCCGGAGTTGGGGGTACCCGTTGCAGAGCCAGGGACATGATGCAGGCGAAGCTTGGGATCTGGCCAAGTTGGACTTTGA
TCCTTTGGGCAGATGTCCCATTGCTCCCTGGAGCCTGTCATGCCTGTTGGGGATCAGGCAGCCTCCTGATGCCAGAACACCTCAGGCAGA
GCCCTACTCAGCTGTACCTGTCTGCCTGGACTGTCCCCTGTCCCCGCATCTCCCCTGGGACCAGCTGGAGGGCCACATGCACACACAGCC
TAGCTGCCCCCAGGGAGCTCTGCTGCCCTTGCTGGCCCTGCCCTTCCCACAGGTGAGCAGGGCTCCTGTCCACCAGCACACTCAGTTCTC
TTCCCTGCAGTGTTTTCATTTTATTTTAGCCAAACATTTTGCCTGTTTTCTGTTTCAAACATGATAGTTGATATGAGACTGAAACCCCTG
GGTTGTGGAGGGAAATTGGCTCAGAGATGGACAACCTGGCAACTGTGAGTCCCTGCTTCCCGACACCAGCCTCATGGAATATGCAACAAC
TCCTGTACCCCAGTCCACGGTGTTCTGGCAGCAGGGACACCTGGGCCAATGGGCCATCTGGACCAAAGGTGGGGTGTGGGGCCCTGGATG
GCAGCTCTGGCCCAGACATGAATACCTCGTGTTCCTCCTCCCTCTATTACTGTTTCACCAGAGCTGTCTTAGCTCAAATCTGTTGTGTTT
CTGAGTCTAGGGTCTGTACACTTGTTTATAATAAATGCAATCGTTTGGAGCTGCTGCCCCCTTTCTTCCTGGCCTCGGCTGCTGGAATTG

>In-frame_ENST00000542407_ENST00000296444_TCGA-LL-A7T0-01A_PDLIM5_chr4_95539342_+_SHISA5_chr3_48538726_length(amino acids)=462AA_start in transcript=309_stop in transcript=1697
MAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSV
CSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADN
TKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGARGEVCMASRGLSLFPESCPDFC
CGTCDDQYCCSDVLKKFVWSEERCAVPEASVPASVEPVEQLGSALRFRPGYNDPMSGFGATLAVGLTIFVLSVVTIIICFTCSCCCLYKT
CRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPGPSYQGYHTMPPQPGMPAAPYPMQYPPPYPAQPMGPPAYHETLAGGAAAPYPASQPPY

--------------------------------------------------------------
>In-frame_ENST00000514743_ENST00000296444_TCGA-LL-A7T0-01A_PDLIM5_chr4_95539342_+_SHISA5_chr3_48538726_length(transcript)=3195nt_BP=1239nt
AGCATATTTCATTTTCTGTCATTGGACTTTGAGCCATTAGAACCATGAGCAACTACAGTGTGTCACTGGTTGGCCCAGCTCCTTGGGGTT
TCCGGCTGCAGGGCGGTAAGGATTTCAACATGCCTCTGACAATCTCTAGTCTAAAAGATGGCGGCAAGGCAGCCCAGGCAAATGTAAGAA
TAGGCGATGTGGTTCTCAGCATTGATGGAATAAATGCACAAGGAATGACTCATCTTGAAGCCCAGAATAAGATTAAGGGTTGTACAGGCT
CTTTGAATATGACTCTGCAAAGAGCATCTGCTGCACCCAAGCCTGAGCCGGTTCCTGTTCAAAAGCCCACAGTCACCAGCGTGTGTTCCG
AGACTTCTCAGGAGCTAGCAGAGGGACAGAGAAGAGGATCCCAGGGTGACAGTAAACAGCAAAATGGGAAAATCCCACCTAAACGCCCAC
CAAGAAAACACATTGTGGAGCGCTATACAGAGTTTTATCATGTACCCACTCACAGTGATGCCAGCAAGAAGAGACTGATTGAGGATACTG
AAGACTGGCGTCCAAGGACTGGAACAACTCAGTCTCGCTCTTTCCGAATCCTTGCCCAGATCACTGGGACTGAACATTTGAAAGAATCTG
AAGCCGATAATACAAAGAAGGCAAAGTTTGACAGTGCTCTGGAAGACCTACCTAAGAGTGGACCTCACCCTCCTGCAACTCCTCAGGTGT
TAACTATTGGTAGCCAAGTGGCCACACTTTCTAAAGTAGCAACTACTTATTCTAGTTTAAGCAGCTCCACAGGAAATGTGGAAGATTCTT
TCGAAGGTTTTCGAAACTTTTCTACCTTCTCTTCTCCTGCTAGATATAGTGCTGCAGTTCTGAGCAGCGCAGCTGCTACTGTGTCTGCTG
TTATTGCTACAAAAACCAGGCTCTACACTCCTGAAAGATATCACTCACTCCTGGATGCACTTTGCATCAGCCCTGTCTCCAAGCCTTTAG
CTTTTTCCTATCTGCAGTCCTCAAGGAAATCAACTGGCTCTATCCATGTTAAGAAAACAAGTAACTCTCAGGAGCCTTCTCCGCAGTTGG
CTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCTGCAG
CTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCAAGCTGGCAACGGCCAAACCAAGGAGCACGTGGTGAGGTGTGTATGG
CTTCCCGTGGACTCAGCCTCTTCCCCGAGTCCTGTCCAGATTTCTGCTGTGGTACCTGTGATGACCAATACTGCTGCTCTGACGTGCTGA
AGAAATTTGTGTGGAGCGAGGAAAGGTGTGCTGTGCCTGAGGCCAGCGTGCCTGCCAGTGTAGAGCCGGTGGAGCAGCTGGGCTCGGCGC
TGAGGTTTCGCCCTGGCTACAACGACCCCATGTCAGGGTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCA
CTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCA
CTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTC
AGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCC
TGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTACAACCCGGCCTACATGGATGCCCCGAAGGCGGCCCTCTGAGCAT
TCCCTGGCCTCTCTGGCTGCCACTTGGTTATGTTGTGTGTGTGCGTGAGTGGTGTGCAGGCGCGGTTCCTTACGCCCCATGTGTGCTGTG
TGTGTCCAGGCACGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCTGCCTGTATATGTGGCTTCCTCTGATGCTGACAAGGTGGGGAA
CAATCCTTGCCAGAGTGGGCTGGGACCAGACTTTGTTCTCTTCCTCACCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCAAAGAA
TGGGGTGGTGGGGGGCACCCTGTGAGGTGGCCCCTGAGAGGTGGGGGCCTCTCCAGGGCACATCTGGAGTTCTTCTCCAGCTTACCCTAG
GGTGACCAAGTAGGGCCTGTCACACCAGGGTGGCGCAGCTTTCTGTGTGATGCAGATGTGTCCTGGTTTCGGCAGCGTAGCCAGCTGCTG
CTTGAGGCCATGGCTCGTCCCCGGAGTTGGGGGTACCCGTTGCAGAGCCAGGGACATGATGCAGGCGAAGCTTGGGATCTGGCCAAGTTG
GACTTTGATCCTTTGGGCAGATGTCCCATTGCTCCCTGGAGCCTGTCATGCCTGTTGGGGATCAGGCAGCCTCCTGATGCCAGAACACCT
CAGGCAGAGCCCTACTCAGCTGTACCTGTCTGCCTGGACTGTCCCCTGTCCCCGCATCTCCCCTGGGACCAGCTGGAGGGCCACATGCAC
ACACAGCCTAGCTGCCCCCAGGGAGCTCTGCTGCCCTTGCTGGCCCTGCCCTTCCCACAGGTGAGCAGGGCTCCTGTCCACCAGCACACT
CAGTTCTCTTCCCTGCAGTGTTTTCATTTTATTTTAGCCAAACATTTTGCCTGTTTTCTGTTTCAAACATGATAGTTGATATGAGACTGA
AACCCCTGGGTTGTGGAGGGAAATTGGCTCAGAGATGGACAACCTGGCAACTGTGAGTCCCTGCTTCCCGACACCAGCCTCATGGAATAT
GCAACAACTCCTGTACCCCAGTCCACGGTGTTCTGGCAGCAGGGACACCTGGGCCAATGGGCCATCTGGACCAAAGGTGGGGTGTGGGGC
CCTGGATGGCAGCTCTGGCCCAGACATGAATACCTCGTGTTCCTCCTCCCTCTATTACTGTTTCACCAGAGCTGTCTTAGCTCAAATCTG
TTGTGTTTCTGAGTCTAGGGTCTGTACACTTGTTTATAATAAATGCAATCGTTTGGAGCTGCTGCCCCCTTTCTTCCTGGCCTCGGCTGC

>In-frame_ENST00000514743_ENST00000296444_TCGA-LL-A7T0-01A_PDLIM5_chr4_95539342_+_SHISA5_chr3_48538726_length(amino acids)=613AA_start in transcript=44_stop in transcript=1885
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKP
EPVPVQKPTVTSVCSETSQELAEGQRRGSQGDSKQQNGKIPPKRPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSF
RILAQITGTEHLKESEADNTKKAKFDSALEDLPKSGPHPPATPQVLTIGSQVATLSKVATTYSSLSSSTGNVEDSFEGFRNFSTFSSPAR
YSAAVLSSAAATVSAVIATKTRLYTPERYHSLLDALCISPVSKPLAFSYLQSSRKSTGSIHVKKTSNSQEPSPQLASSVASTRSMPESLD
SPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGARGEVCMASRGLSLFPESCPDFCCGTCDDQYCCSDVLKKFVWSEERCAVPEA
SVPASVEPVEQLGSALRFRPGYNDPMSGFGATLAVGLTIFVLSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PDLIM5-SHISA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDLIM5-SHISA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDLIM5-SHISA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDLIM5C0005586Bipolar Disorder5PSYGENET
HgenePDLIM5C0036341Schizophrenia4PSYGENET
HgenePDLIM5C0041696Unipolar Depression4PSYGENET
HgenePDLIM5C1269683Major Depressive Disorder4PSYGENET
HgenePDLIM5C0019193Hepatitis, Toxic1CTD_human
HgenePDLIM5C0151744Myocardial Ischemia1CTD_human
HgenePDLIM5C0860207Drug-Induced Liver Disease1CTD_human
HgenePDLIM5C1262760Hepatitis, Drug-Induced1CTD_human
HgenePDLIM5C3658290Drug-Induced Acute Liver Injury1CTD_human
HgenePDLIM5C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgenePDLIM5C4279912Chemically-Induced Liver Toxicity1CTD_human