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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDPR-VIM (FusionGDB2 ID:63644)

Fusion Gene Summary for PDPR-VIM

check button Fusion gene summary
Fusion gene informationFusion gene name: PDPR-VIM
Fusion gene ID: 63644
HgeneTgene
Gene symbol

PDPR

VIM

Gene ID

55066

7431

Gene namepyruvate dehydrogenase phosphatase regulatory subunitvimentin
SynonymsPDP3-
Cytomap

16q22.1

10p13

Type of geneprotein-codingprotein-coding
Descriptionpyruvate dehydrogenase phosphatase regulatory subunit, mitochondrialvimentinepididymis secretory sperm binding protein
Modification date2020031320200327
UniProtAcc.

VMAC

Ensembl transtripts involved in fusion geneENST00000288050, ENST00000398122, 
ENST00000568530, ENST00000562100, 
ENST00000567046, ENST00000542659, 
ENST00000544301, ENST00000224237, 
ENST00000485947, 
Fusion gene scores* DoF score8 X 8 X 4=25642 X 25 X 11=11550
# samples 841
** MAII scorelog2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/11550*10)=-4.81612513168534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDPR [Title/Abstract] AND VIM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDPR(70164447)-VIM(17276691), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PDPR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across VIM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-4790PDPRchr16

70164447

+VIMchr10

17276691

+


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Fusion Gene ORF analysis for PDPR-VIM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000288050ENST00000544301PDPRchr16

70164447

+VIMchr10

17276691

+
In-frameENST00000288050ENST00000224237PDPRchr16

70164447

+VIMchr10

17276691

+
5CDS-intronENST00000288050ENST00000485947PDPRchr16

70164447

+VIMchr10

17276691

+
In-frameENST00000398122ENST00000544301PDPRchr16

70164447

+VIMchr10

17276691

+
In-frameENST00000398122ENST00000224237PDPRchr16

70164447

+VIMchr10

17276691

+
5CDS-intronENST00000398122ENST00000485947PDPRchr16

70164447

+VIMchr10

17276691

+
In-frameENST00000568530ENST00000544301PDPRchr16

70164447

+VIMchr10

17276691

+
In-frameENST00000568530ENST00000224237PDPRchr16

70164447

+VIMchr10

17276691

+
5CDS-intronENST00000568530ENST00000485947PDPRchr16

70164447

+VIMchr10

17276691

+
intron-3CDSENST00000562100ENST00000544301PDPRchr16

70164447

+VIMchr10

17276691

+
intron-3CDSENST00000562100ENST00000224237PDPRchr16

70164447

+VIMchr10

17276691

+
intron-intronENST00000562100ENST00000485947PDPRchr16

70164447

+VIMchr10

17276691

+
intron-3CDSENST00000567046ENST00000544301PDPRchr16

70164447

+VIMchr10

17276691

+
intron-3CDSENST00000567046ENST00000224237PDPRchr16

70164447

+VIMchr10

17276691

+
intron-intronENST00000567046ENST00000485947PDPRchr16

70164447

+VIMchr10

17276691

+
intron-3CDSENST00000542659ENST00000544301PDPRchr16

70164447

+VIMchr10

17276691

+
intron-3CDSENST00000542659ENST00000224237PDPRchr16

70164447

+VIMchr10

17276691

+
intron-intronENST00000542659ENST00000485947PDPRchr16

70164447

+VIMchr10

17276691

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000288050PDPRchr1670164447+ENST00000544301VIMchr1017276691+251916869452204419
ENST00000288050PDPRchr1670164447+ENST00000224237VIMchr1017276691+252716869452204419
ENST00000398122PDPRchr1670164447+ENST00000544301VIMchr1017276691+1404571701089339
ENST00000398122PDPRchr1670164447+ENST00000224237VIMchr1017276691+1412571701089339
ENST00000568530PDPRchr1670164447+ENST00000544301VIMchr1017276691+17248911501409419
ENST00000568530PDPRchr1670164447+ENST00000224237VIMchr1017276691+17328911501409419

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000288050ENST00000544301PDPRchr1670164447+VIMchr1017276691+0.0031951840.99680483
ENST00000288050ENST00000224237PDPRchr1670164447+VIMchr1017276691+0.0031635510.9968364
ENST00000398122ENST00000544301PDPRchr1670164447+VIMchr1017276691+0.0021165920.9978834
ENST00000398122ENST00000224237PDPRchr1670164447+VIMchr1017276691+0.0020791390.99792093
ENST00000568530ENST00000544301PDPRchr1670164447+VIMchr1017276691+0.0027601330.9972398
ENST00000568530ENST00000224237PDPRchr1670164447+VIMchr1017276691+0.0026659940.997334

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Fusion Genomic Features for PDPR-VIM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PDPRchr1670164447+VIMchr1017276691+2.33E-060.9999976
PDPRchr1670164447+VIMchr1017276691+2.33E-060.9999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDPR-VIM


check button Go to

FGviewer for the breakpoints of chr16:70164447-chr10:17276691

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.VIM

VMAC

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.169

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVIMchr16:70164447chr10:17276691ENST0000022423739303_407294.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr16:70164447chr10:17276691ENST00000544301410303_407294.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr16:70164447chr10:17276691ENST0000022423739326_329294.0467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr16:70164447chr10:17276691ENST00000544301410326_329294.0467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr16:70164447chr10:17276691ENST0000022423739408_466294.0467.0RegionNote=Tail
TgeneVIMchr16:70164447chr10:17276691ENST00000544301410408_466294.0467.0RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVIMchr16:70164447chr10:17276691ENST0000022423739154_245294.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr16:70164447chr10:17276691ENST000002242373996_131294.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr16:70164447chr10:17276691ENST00000544301410154_245294.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr16:70164447chr10:17276691ENST0000054430141096_131294.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr16:70164447chr10:17276691ENST0000022423739103_411294.0467.0DomainIF rod
TgeneVIMchr16:70164447chr10:17276691ENST00000544301410103_411294.0467.0DomainIF rod
TgeneVIMchr16:70164447chr10:17276691ENST0000022423739132_153294.0467.0RegionNote=Linker 1
TgeneVIMchr16:70164447chr10:17276691ENST0000022423739246_268294.0467.0RegionNote=Linker 12
TgeneVIMchr16:70164447chr10:17276691ENST0000022423739269_407294.0467.0RegionNote=Coil 2
TgeneVIMchr16:70164447chr10:17276691ENST00000224237392_95294.0467.0RegionNote=Head
TgeneVIMchr16:70164447chr10:17276691ENST00000544301410132_153294.0467.0RegionNote=Linker 1
TgeneVIMchr16:70164447chr10:17276691ENST00000544301410246_268294.0467.0RegionNote=Linker 12
TgeneVIMchr16:70164447chr10:17276691ENST00000544301410269_407294.0467.0RegionNote=Coil 2
TgeneVIMchr16:70164447chr10:17276691ENST000005443014102_95294.0467.0RegionNote=Head


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Fusion Gene Sequence for PDPR-VIM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000288050_ENST00000544301_TCGA-BP-4790_PDPR_chr16_70164447_+_VIM_chr10_17276691_length(transcript)=2519nt_BP=1686nt
CAGTGATGAGTTCTAGAAGGAAAGAAAAGGCTGATGTGACAGTGAGGAAGGGATGAGTGGAGACTTCTCTGAGACTTCAGTGATTCCTCT
TCCTCTGAGCTGAGCCAAGCTGAGAAGCTGAGAAGAGTAAGATAGGGCCGGGAACTCAGGTCCGTTAGTCCGTCCTCCGAGGTGGGGCGG
GCCAGCAGAATGGATTTCCGATCTACTCTGTGAGAGCCTCGCCCAAGAAAGCCCAGAGCCACTTCCAAGATCCGCGCTCCCACGGCGATG
AGAAGCGTTTTCCCCCGGGACTGCTTGGCTTAGGACTGGGGACCCACTGGCTTTGGAGTAAGCCCTGGCACGGGCCTCGAGGGAAGAAAG
AACTCCCGCGCTCCCCACACTCCACAGGGCCTGCGATCATCTCAGATGTTCCGGTTCCACGTGCAGAAACCCCGCCGGTCCGAGGCCCCG
GTTCTAAAACGGCCCTAAGAGTCAAGGCTTCCACAGCTCGCCTCTGAGGGTGGCAAAGAGGCCGCGGGGGCGGTGCCTCGCGAGACCCAA
ACAAGCCCACGTGGCAGGGGCGGGGCTCCGCGAAGGCGTCACGGCGCGCTCGTGCGCTGCTGAGGTCACGCGCCGGCAGTACCCTTGCCC
GGGGGCCGTAAAGCGCGGAAGGTCGCGGTCTCGGCTTCCCCGGAACTTTTTGCTCGCTTCGCCCCGCCCCCTTCCCATCCCCGAACCCCG
CTTTCCGGCCCGCGGCGACCCCAGGCAACTGTTGTGGCTGCCGCATTGCTCCCGCCGGGCTGTAGCTGAGCGCGGAGCCCGTGGGGACCG
GTGAGATGGAACTGTTTTCCCGCGTTGAGACGTGCGGTCCGCTTGTGCTTTTAGAACTAAAGACTGCTGCAGAGTCCGGAGGAAGAAGTC
ACCTAGAAAAATCTGGGACAGGGCATTTGAGTTCCTGAGATCTAGTTGGTGAGAGACATGATGTTCTACCGGTTGCTGTCGATTGTTGGA
AGACAAAGAGCCAGCCCAGGATGGCAGAACTGGTCCTCTGCAAGAAACAGCACGTCAGCTGCCGAGGCGCGTTCCATGGCCCTGCCCACC
CAGGCACAGGTGGTCATCTGTGGAGGTGGAATCACGGGCACTTCTGTGGCCTATCACCTCTCCAAAATGGGGTGGAAGGATATTGTCCTT
TTGGAGCAGGGCAGGCTGGCTGCTGGCTCTACCAGGTTCTGTGCTGGCATCCTGAGCACTGCCAGGCACTTGACCATTGAGCAGAAGATG
GCAGACTACTCAAACAAACTCTACTATCAGTTAGAGCAAGAAACAGGGATCCAAACAGGTTACACAAGGACAGGCTCAATCTTTCTGGCC
CAAACTCAGGACCGACTGATCTCCCTGAAGCGCATCAACGCAGGGCTGAATGTTATAGGTATCCCTTCTGAGATCATCTCCCCCAAGAAA
GTGGCCGAGCTTCACCATCTCCTCAACGTGCACGACCTGGTGGGGGCCATGCATGTTCCCGAGGATGCAGTGGTGTCTTCCGCTGACGTG
GCTCTTGCCCTGGCAAGTGCTGCCTCCCAAAATGGTGTTCAGATCTATGACCGGACATCTGTTCTTCATGTAATGGTCAAAAAAGGTCAA
GTTACTGGAGTGGAGACCGATAAAGGACAGATTGAATGCCAGTATTTTGTCAACTGTGCTGGCCAGTTTGCTGACCTCTCTGAGGCTGCC
AACCGGAACAATGACGCCCTGCGCCAGGCAAAGCAGGAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACCTGTGAAGTGGATGCC
CTTAAAGGAACCAATGAGTCCCTGGAACGCCAGATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATT
GGCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCC
CTTGACATTGAGATTGCCACCTACAGGAAGCTGCTGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAAC
CTGAGGGAAACTAATCTGGATTCACTCCCTCTGGTTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGA
CAGGTTATCAACGAAACTTCTCAGCATCACGATGACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAA
AAAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCT
CTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTT

>In-frame_ENST00000288050_ENST00000544301_TCGA-BP-4790_PDPR_chr16_70164447_+_VIM_chr10_17276691_length(amino acids)=419AA_start in transcript=945_stop in transcript=2204
MVRDMMFYRLLSIVGRQRASPGWQNWSSARNSTSAAEARSMALPTQAQVVICGGGITGTSVAYHLSKMGWKDIVLLEQGRLAAGSTRFCA
GILSTARHLTIEQKMADYSNKLYYQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVG
AMHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQFADLSEAANRNNDALRQAKQEST
EYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGE

--------------------------------------------------------------
>In-frame_ENST00000288050_ENST00000224237_TCGA-BP-4790_PDPR_chr16_70164447_+_VIM_chr10_17276691_length(transcript)=2527nt_BP=1686nt
CAGTGATGAGTTCTAGAAGGAAAGAAAAGGCTGATGTGACAGTGAGGAAGGGATGAGTGGAGACTTCTCTGAGACTTCAGTGATTCCTCT
TCCTCTGAGCTGAGCCAAGCTGAGAAGCTGAGAAGAGTAAGATAGGGCCGGGAACTCAGGTCCGTTAGTCCGTCCTCCGAGGTGGGGCGG
GCCAGCAGAATGGATTTCCGATCTACTCTGTGAGAGCCTCGCCCAAGAAAGCCCAGAGCCACTTCCAAGATCCGCGCTCCCACGGCGATG
AGAAGCGTTTTCCCCCGGGACTGCTTGGCTTAGGACTGGGGACCCACTGGCTTTGGAGTAAGCCCTGGCACGGGCCTCGAGGGAAGAAAG
AACTCCCGCGCTCCCCACACTCCACAGGGCCTGCGATCATCTCAGATGTTCCGGTTCCACGTGCAGAAACCCCGCCGGTCCGAGGCCCCG
GTTCTAAAACGGCCCTAAGAGTCAAGGCTTCCACAGCTCGCCTCTGAGGGTGGCAAAGAGGCCGCGGGGGCGGTGCCTCGCGAGACCCAA
ACAAGCCCACGTGGCAGGGGCGGGGCTCCGCGAAGGCGTCACGGCGCGCTCGTGCGCTGCTGAGGTCACGCGCCGGCAGTACCCTTGCCC
GGGGGCCGTAAAGCGCGGAAGGTCGCGGTCTCGGCTTCCCCGGAACTTTTTGCTCGCTTCGCCCCGCCCCCTTCCCATCCCCGAACCCCG
CTTTCCGGCCCGCGGCGACCCCAGGCAACTGTTGTGGCTGCCGCATTGCTCCCGCCGGGCTGTAGCTGAGCGCGGAGCCCGTGGGGACCG
GTGAGATGGAACTGTTTTCCCGCGTTGAGACGTGCGGTCCGCTTGTGCTTTTAGAACTAAAGACTGCTGCAGAGTCCGGAGGAAGAAGTC
ACCTAGAAAAATCTGGGACAGGGCATTTGAGTTCCTGAGATCTAGTTGGTGAGAGACATGATGTTCTACCGGTTGCTGTCGATTGTTGGA
AGACAAAGAGCCAGCCCAGGATGGCAGAACTGGTCCTCTGCAAGAAACAGCACGTCAGCTGCCGAGGCGCGTTCCATGGCCCTGCCCACC
CAGGCACAGGTGGTCATCTGTGGAGGTGGAATCACGGGCACTTCTGTGGCCTATCACCTCTCCAAAATGGGGTGGAAGGATATTGTCCTT
TTGGAGCAGGGCAGGCTGGCTGCTGGCTCTACCAGGTTCTGTGCTGGCATCCTGAGCACTGCCAGGCACTTGACCATTGAGCAGAAGATG
GCAGACTACTCAAACAAACTCTACTATCAGTTAGAGCAAGAAACAGGGATCCAAACAGGTTACACAAGGACAGGCTCAATCTTTCTGGCC
CAAACTCAGGACCGACTGATCTCCCTGAAGCGCATCAACGCAGGGCTGAATGTTATAGGTATCCCTTCTGAGATCATCTCCCCCAAGAAA
GTGGCCGAGCTTCACCATCTCCTCAACGTGCACGACCTGGTGGGGGCCATGCATGTTCCCGAGGATGCAGTGGTGTCTTCCGCTGACGTG
GCTCTTGCCCTGGCAAGTGCTGCCTCCCAAAATGGTGTTCAGATCTATGACCGGACATCTGTTCTTCATGTAATGGTCAAAAAAGGTCAA
GTTACTGGAGTGGAGACCGATAAAGGACAGATTGAATGCCAGTATTTTGTCAACTGTGCTGGCCAGTTTGCTGACCTCTCTGAGGCTGCC
AACCGGAACAATGACGCCCTGCGCCAGGCAAAGCAGGAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACCTGTGAAGTGGATGCC
CTTAAAGGAACCAATGAGTCCCTGGAACGCCAGATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATT
GGCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCC
CTTGACATTGAGATTGCCACCTACAGGAAGCTGCTGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAAC
CTGAGGGAAACTAATCTGGATTCACTCCCTCTGGTTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGA
CAGGTTATCAACGAAACTTCTCAGCATCACGATGACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAA
AAAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCT
CTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTT
TTTAAAAGGTATTTTGAATACCATTAAAACTGCTTTTTTTTTTCCAGCAAGTATCCAACCAACTTGGTTCTGCTTCAATAAATCTTTGGA

>In-frame_ENST00000288050_ENST00000224237_TCGA-BP-4790_PDPR_chr16_70164447_+_VIM_chr10_17276691_length(amino acids)=419AA_start in transcript=945_stop in transcript=2204
MVRDMMFYRLLSIVGRQRASPGWQNWSSARNSTSAAEARSMALPTQAQVVICGGGITGTSVAYHLSKMGWKDIVLLEQGRLAAGSTRFCA
GILSTARHLTIEQKMADYSNKLYYQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVG
AMHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQFADLSEAANRNNDALRQAKQEST
EYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGE

--------------------------------------------------------------
>In-frame_ENST00000398122_ENST00000544301_TCGA-BP-4790_PDPR_chr16_70164447_+_VIM_chr10_17276691_length(transcript)=1404nt_BP=571nt
AACTGTTGTGGCTGCCGCATTGCTCCCGCCGGGCTGTAGCTGAGCGCGGAGCCCGTGGGGACCGGTGAGGCTGGCTGCTGGCTCTACCAG
GTTCTGTGCTGGCATCCTGAGCACTGCCAGGCACTTGACCATTGAGCAGAAGATGGCAGACTACTCAAACAAACTCTACTATCAGTTAGA
GCAAGAAACAGGGATCCAAACAGGTTACACAAGGACAGGCTCAATCTTTCTGGCCCAAACTCAGGACCGACTGATCTCCCTGAAGCGCAT
CAACGCAGGGCTGAATGTTATAGGTATCCCTTCTGAGATCATCTCCCCCAAGAAAGTGGCCGAGCTTCACCATCTCCTCAACGTGCACGA
CCTGGTGGGGGCCATGCATGTTCCCGAGGATGCAGTGGTGTCTTCCGCTGACGTGGCTCTTGCCCTGGCAAGTGCTGCCTCCCAAAATGG
TGTTCAGATCTATGACCGGACATCTGTTCTTCATGTAATGGTCAAAAAAGGTCAAGTTACTGGAGTGGAGACCGATAAAGGACAGATTGA
ATGCCAGTATTTTGTCAACTGTGCTGGCCAGTTTGCTGACCTCTCTGAGGCTGCCAACCGGAACAATGACGCCCTGCGCCAGGCAAAGCA
GGAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACCTGTGAAGTGGATGCCCTTAAAGGAACCAATGAGTCCCTGGAACGCCAGAT
GCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGGA
GGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTACAGGAAGCTGCT
GGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAACCTGAGGGAAACTAATCTGGATTCACTCCCTCTGGT
TGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATGA
CCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCAA
GTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTA
GAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAAACTGCTT

>In-frame_ENST00000398122_ENST00000544301_TCGA-BP-4790_PDPR_chr16_70164447_+_VIM_chr10_17276691_length(amino acids)=339AA_start in transcript=70_stop in transcript=1089
MAAGSTRFCAGILSTARHLTIEQKMADYSNKLYYQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELH
HLLNVHDLVGAMHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQFADLSEAANRNND
ALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEI

--------------------------------------------------------------
>In-frame_ENST00000398122_ENST00000224237_TCGA-BP-4790_PDPR_chr16_70164447_+_VIM_chr10_17276691_length(transcript)=1412nt_BP=571nt
AACTGTTGTGGCTGCCGCATTGCTCCCGCCGGGCTGTAGCTGAGCGCGGAGCCCGTGGGGACCGGTGAGGCTGGCTGCTGGCTCTACCAG
GTTCTGTGCTGGCATCCTGAGCACTGCCAGGCACTTGACCATTGAGCAGAAGATGGCAGACTACTCAAACAAACTCTACTATCAGTTAGA
GCAAGAAACAGGGATCCAAACAGGTTACACAAGGACAGGCTCAATCTTTCTGGCCCAAACTCAGGACCGACTGATCTCCCTGAAGCGCAT
CAACGCAGGGCTGAATGTTATAGGTATCCCTTCTGAGATCATCTCCCCCAAGAAAGTGGCCGAGCTTCACCATCTCCTCAACGTGCACGA
CCTGGTGGGGGCCATGCATGTTCCCGAGGATGCAGTGGTGTCTTCCGCTGACGTGGCTCTTGCCCTGGCAAGTGCTGCCTCCCAAAATGG
TGTTCAGATCTATGACCGGACATCTGTTCTTCATGTAATGGTCAAAAAAGGTCAAGTTACTGGAGTGGAGACCGATAAAGGACAGATTGA
ATGCCAGTATTTTGTCAACTGTGCTGGCCAGTTTGCTGACCTCTCTGAGGCTGCCAACCGGAACAATGACGCCCTGCGCCAGGCAAAGCA
GGAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACCTGTGAAGTGGATGCCCTTAAAGGAACCAATGAGTCCCTGGAACGCCAGAT
GCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGGA
GGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTACAGGAAGCTGCT
GGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAACCTGAGGGAAACTAATCTGGATTCACTCCCTCTGGT
TGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATGA
CCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCAA
GTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTA
GAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAAACTGCTT

>In-frame_ENST00000398122_ENST00000224237_TCGA-BP-4790_PDPR_chr16_70164447_+_VIM_chr10_17276691_length(amino acids)=339AA_start in transcript=70_stop in transcript=1089
MAAGSTRFCAGILSTARHLTIEQKMADYSNKLYYQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELH
HLLNVHDLVGAMHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQFADLSEAANRNND
ALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEI

--------------------------------------------------------------
>In-frame_ENST00000568530_ENST00000544301_TCGA-BP-4790_PDPR_chr16_70164447_+_VIM_chr10_17276691_length(transcript)=1724nt_BP=891nt
AACTGTTGTGGCTGCCGCATTGCTCCCGCCGGGCTGTAGCTGAGCGCGGAGCCCGTGGGGACCGGTGAGAACTAAAGACTGCTGCAGAGT
CCGGAGGAAGAAGTCACCTAGAAAAATCTGGGACAGGGCATTTGAGTTCCTGAGATCTAGTTGGTGAGAGACATGATGTTCTACCGGTTG
CTGTCGATTGTTGGAAGACAAAGAGCCAGCCCAGGATGGCAGAACTGGTCCTCTGCAAGAAACAGCACGTCAGCTGCCGAGGCGCGTTCC
ATGGCCCTGCCCACCCAGGCACAGGTGGTCATCTGTGGAGGTGGAATCACGGGCACTTCTGTGGCCTATCACCTCTCCAAAATGGGGTGG
AAGGATATTGTCCTTTTGGAGCAGGGCAGGCTGGCTGCTGGCTCTACCAGGTTCTGTGCTGGCATCCTGAGCACTGCCAGGCACTTGACC
ATTGAGCAGAAGATGGCAGACTACTCAAACAAACTCTACTATCAGTTAGAGCAAGAAACAGGGATCCAAACAGGTTACACAAGGACAGGC
TCAATCTTTCTGGCCCAAACTCAGGACCGACTGATCTCCCTGAAGCGCATCAACGCAGGGCTGAATGTTATAGGTATCCCTTCTGAGATC
ATCTCCCCCAAGAAAGTGGCCGAGCTTCACCATCTCCTCAACGTGCACGACCTGGTGGGGGCCATGCATGTTCCCGAGGATGCAGTGGTG
TCTTCCGCTGACGTGGCTCTTGCCCTGGCAAGTGCTGCCTCCCAAAATGGTGTTCAGATCTATGACCGGACATCTGTTCTTCATGTAATG
GTCAAAAAAGGTCAAGTTACTGGAGTGGAGACCGATAAAGGACAGATTGAATGCCAGTATTTTGTCAACTGTGCTGGCCAGTTTGCTGAC
CTCTCTGAGGCTGCCAACCGGAACAATGACGCCCTGCGCCAGGCAAAGCAGGAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACC
TGTGAAGTGGATGCCCTTAAAGGAACCAATGAGTCCCTGGAACGCCAGATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAAC
TACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTC
AATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTACAGGAAGCTGCTGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAAC
TTTTCCTCCCTGAACCTGAGGGAAACTAATCTGGATTCACTCCCTCTGGTTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTT
GAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATGACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATAT
TACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTG
GAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAATCT
TGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAAACTGCTTTTTTTTTTCCAGCAAGTATCCAACCAACTTGGTTCTGCTT

>In-frame_ENST00000568530_ENST00000544301_TCGA-BP-4790_PDPR_chr16_70164447_+_VIM_chr10_17276691_length(amino acids)=419AA_start in transcript=150_stop in transcript=1409
MVRDMMFYRLLSIVGRQRASPGWQNWSSARNSTSAAEARSMALPTQAQVVICGGGITGTSVAYHLSKMGWKDIVLLEQGRLAAGSTRFCA
GILSTARHLTIEQKMADYSNKLYYQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVG
AMHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQFADLSEAANRNNDALRQAKQEST
EYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGE

--------------------------------------------------------------
>In-frame_ENST00000568530_ENST00000224237_TCGA-BP-4790_PDPR_chr16_70164447_+_VIM_chr10_17276691_length(transcript)=1732nt_BP=891nt
AACTGTTGTGGCTGCCGCATTGCTCCCGCCGGGCTGTAGCTGAGCGCGGAGCCCGTGGGGACCGGTGAGAACTAAAGACTGCTGCAGAGT
CCGGAGGAAGAAGTCACCTAGAAAAATCTGGGACAGGGCATTTGAGTTCCTGAGATCTAGTTGGTGAGAGACATGATGTTCTACCGGTTG
CTGTCGATTGTTGGAAGACAAAGAGCCAGCCCAGGATGGCAGAACTGGTCCTCTGCAAGAAACAGCACGTCAGCTGCCGAGGCGCGTTCC
ATGGCCCTGCCCACCCAGGCACAGGTGGTCATCTGTGGAGGTGGAATCACGGGCACTTCTGTGGCCTATCACCTCTCCAAAATGGGGTGG
AAGGATATTGTCCTTTTGGAGCAGGGCAGGCTGGCTGCTGGCTCTACCAGGTTCTGTGCTGGCATCCTGAGCACTGCCAGGCACTTGACC
ATTGAGCAGAAGATGGCAGACTACTCAAACAAACTCTACTATCAGTTAGAGCAAGAAACAGGGATCCAAACAGGTTACACAAGGACAGGC
TCAATCTTTCTGGCCCAAACTCAGGACCGACTGATCTCCCTGAAGCGCATCAACGCAGGGCTGAATGTTATAGGTATCCCTTCTGAGATC
ATCTCCCCCAAGAAAGTGGCCGAGCTTCACCATCTCCTCAACGTGCACGACCTGGTGGGGGCCATGCATGTTCCCGAGGATGCAGTGGTG
TCTTCCGCTGACGTGGCTCTTGCCCTGGCAAGTGCTGCCTCCCAAAATGGTGTTCAGATCTATGACCGGACATCTGTTCTTCATGTAATG
GTCAAAAAAGGTCAAGTTACTGGAGTGGAGACCGATAAAGGACAGATTGAATGCCAGTATTTTGTCAACTGTGCTGGCCAGTTTGCTGAC
CTCTCTGAGGCTGCCAACCGGAACAATGACGCCCTGCGCCAGGCAAAGCAGGAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACC
TGTGAAGTGGATGCCCTTAAAGGAACCAATGAGTCCCTGGAACGCCAGATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAAC
TACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTC
AATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTACAGGAAGCTGCTGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAAC
TTTTCCTCCCTGAACCTGAGGGAAACTAATCTGGATTCACTCCCTCTGGTTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTT
GAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATGACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATAT
TACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTG
GAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAATCT
TGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAAACTGCTTTTTTTTTTCCAGCAAGTATCCAACCAACTTGGTTCTGCTT

>In-frame_ENST00000568530_ENST00000224237_TCGA-BP-4790_PDPR_chr16_70164447_+_VIM_chr10_17276691_length(amino acids)=419AA_start in transcript=150_stop in transcript=1409
MVRDMMFYRLLSIVGRQRASPGWQNWSSARNSTSAAEARSMALPTQAQVVICGGGITGTSVAYHLSKMGWKDIVLLEQGRLAAGSTRFCA
GILSTARHLTIEQKMADYSNKLYYQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVG
AMHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQFADLSEAANRNNDALRQAKQEST
EYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PDPR-VIM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDPR-VIM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDPR-VIM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneVIMC0006142Malignant neoplasm of breast4CTD_human
TgeneVIMC0678222Breast Carcinoma4CTD_human
TgeneVIMC1257931Mammary Neoplasms, Human4CTD_human
TgeneVIMC1458155Mammary Neoplasms4CTD_human
TgeneVIMC3805411CATARACT 304GENOMICS_ENGLAND;UNIPROT
TgeneVIMC4704874Mammary Carcinoma, Human4CTD_human
TgeneVIMC0023890Liver Cirrhosis2CTD_human
TgeneVIMC0029408Degenerative polyarthritis2CTD_human
TgeneVIMC0033578Prostatic Neoplasms2CTD_human
TgeneVIMC0086743Osteoarthrosis Deformans2CTD_human
TgeneVIMC0239946Fibrosis, Liver2CTD_human
TgeneVIMC0376358Malignant neoplasm of prostate2CTD_human
TgeneVIMC0007140Carcinosarcoma1CTD_human
TgeneVIMC0007621Neoplastic Cell Transformation1CTD_human
TgeneVIMC0019193Hepatitis, Toxic1CTD_human
TgeneVIMC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneVIMC0027626Neoplasm Invasiveness1CTD_human
TgeneVIMC0027627Neoplasm Metastasis1CTD_human
TgeneVIMC0027720Nephrosis1CTD_human
TgeneVIMC0031149Peritoneal Neoplasms1CTD_human
TgeneVIMC0035126Reperfusion Injury1CTD_human
TgeneVIMC0035309Retinal Diseases1CTD_human
TgeneVIMC0039101synovial sarcoma1CTD_human
TgeneVIMC0043094Weight Gain1CTD_human
TgeneVIMC0085084Motor Neuron Disease1CTD_human
TgeneVIMC0086543Cataract1CTD_human
TgeneVIMC0154681Anterior Horn Cell Disease1CTD_human
TgeneVIMC0154682Lateral Sclerosis1CTD_human
TgeneVIMC0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneVIMC0270763Familial Motor Neuron Disease1CTD_human
TgeneVIMC0270764Motor Neuron Disease, Lower1CTD_human
TgeneVIMC0345967Malignant mesothelioma1CTD_human
TgeneVIMC0346990Carcinomatosis of peritoneal cavity1CTD_human
TgeneVIMC0521659Motor Neuron Disease, Upper1CTD_human
TgeneVIMC0524524Pseudoaphakia1CTD_human
TgeneVIMC0524851Neurodegenerative Disorders1CTD_human
TgeneVIMC0543858Motor Neuron Disease, Secondary1CTD_human
TgeneVIMC0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneVIMC0860207Drug-Induced Liver Disease1CTD_human
TgeneVIMC0948089Acute Coronary Syndrome1CTD_human
TgeneVIMC1262760Hepatitis, Drug-Induced1CTD_human
TgeneVIMC1510497Lens Opacities1CTD_human
TgeneVIMC1833118Cataract, Pulverulent1ORPHANET
TgeneVIMC1852438CATARACT, COPPOCK-LIKE1ORPHANET
TgeneVIMC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneVIMC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneVIMC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneVIMC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneVIMC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneVIMC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human