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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDXK-ABCG1 (FusionGDB2 ID:63721)

Fusion Gene Summary for PDXK-ABCG1

check button Fusion gene summary
Fusion gene informationFusion gene name: PDXK-ABCG1
Fusion gene ID: 63721
HgeneTgene
Gene symbol

PDXK

ABCG1

Gene ID

8566

9619

Gene namepyridoxal kinaseATP binding cassette subfamily G member 1
SynonymsC21orf124|C21orf97|HEL-S-1a|HMSN6C|PKH|PNK|PRED79ABC8|WHITE1
Cytomap

21q22.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionpyridoxal kinaseepididymis secretory sperm binding protein Li 1apyridoxal (pyridoxine, vitamin B6) kinasepyridoxamine kinasepyridoxine kinasevitamin B6 kinaseATP-binding cassette sub-family G member 1ABC transporter 8ATP-binding cassette transporter 8ATP-binding cassette transporter member 1 of subfamily GATP-binding cassette, sub-family G (WHITE), member 1homolog of Drosophila whitewhite protein homolog
Modification date2020031320200329
UniProtAcc.

P45844

Ensembl transtripts involved in fusion geneENST00000398081, ENST00000468090, 
ENST00000291565, ENST00000327574, 
ENST00000476313, ENST00000467908, 
ENST00000398457, ENST00000462050, 
ENST00000347800, ENST00000398449, 
ENST00000361802, ENST00000343687, 
ENST00000398437, ENST00000340588, 
Fusion gene scores* DoF score7 X 9 X 8=5049 X 5 X 8=360
# samples 910
** MAII scorelog2(9/504*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDXK [Title/Abstract] AND ABCG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDXK(45139262)-ABCG1(43645781), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDXK

GO:0042823

pyridoxal phosphate biosynthetic process

9099727|10987144|17766369

TgeneABCG1

GO:0008203

cholesterol metabolic process

15994327

TgeneABCG1

GO:0033344

cholesterol efflux

15994327

TgeneABCG1

GO:0033993

response to lipid

16556852

TgeneABCG1

GO:0034436

glycoprotein transport

17293612

TgeneABCG1

GO:0042632

cholesterol homeostasis

15994327

TgeneABCG1

GO:0042987

amyloid precursor protein catabolic process

17293612

TgeneABCG1

GO:0050714

positive regulation of protein secretion

17293612

TgeneABCG1

GO:1902004

positive regulation of amyloid-beta formation

17293612


check buttonFusion gene breakpoints across PDXK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABCG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-BL-A0C8-01APDXKchr21

45139262

+ABCG1chr21

43645781

+


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Fusion Gene ORF analysis for PDXK-ABCG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000398081ENST00000398457PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000398081ENST00000462050PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000398081ENST00000347800PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000398081ENST00000398449PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000398081ENST00000361802PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000398081ENST00000343687PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-intronENST00000398081ENST00000398437PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-intronENST00000398081ENST00000340588PDXKchr21

45139262

+ABCG1chr21

43645781

+
In-frameENST00000468090ENST00000398457PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000468090ENST00000462050PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000468090ENST00000347800PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000468090ENST00000398449PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000468090ENST00000361802PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000468090ENST00000343687PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-intronENST00000468090ENST00000398437PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-intronENST00000468090ENST00000340588PDXKchr21

45139262

+ABCG1chr21

43645781

+
In-frameENST00000291565ENST00000398457PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000291565ENST00000462050PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000291565ENST00000347800PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000291565ENST00000398449PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000291565ENST00000361802PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000291565ENST00000343687PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-intronENST00000291565ENST00000398437PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-intronENST00000291565ENST00000340588PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3CDSENST00000327574ENST00000398457PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000327574ENST00000462050PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000327574ENST00000347800PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000327574ENST00000398449PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000327574ENST00000361802PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000327574ENST00000343687PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-intronENST00000327574ENST00000398437PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-intronENST00000327574ENST00000340588PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3CDSENST00000476313ENST00000398457PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000476313ENST00000462050PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000476313ENST00000347800PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000476313ENST00000398449PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000476313ENST00000361802PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000476313ENST00000343687PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-intronENST00000476313ENST00000398437PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-intronENST00000476313ENST00000340588PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3CDSENST00000467908ENST00000398457PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000467908ENST00000462050PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000467908ENST00000347800PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000467908ENST00000398449PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000467908ENST00000361802PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000467908ENST00000343687PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-intronENST00000467908ENST00000398437PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-intronENST00000467908ENST00000340588PDXKchr21

45139262

+ABCG1chr21

43645781

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398081PDXKchr2145139262+ENST00000398457ABCG1chr2143645781+3099288302246738
ENST00000468090PDXKchr2145139262+ENST00000398457ABCG1chr2143645781+3096285272243738
ENST00000291565PDXKchr2145139262+ENST00000398457ABCG1chr2143645781+3081270122228738

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398081ENST00000398457PDXKchr2145139262+ABCG1chr2143645781+0.0033491850.9966509
ENST00000468090ENST00000398457PDXKchr2145139262+ABCG1chr2143645781+0.003402430.9965976
ENST00000291565ENST00000398457PDXKchr2145139262+ABCG1chr2143645781+0.0033729720.9966271

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Fusion Genomic Features for PDXK-ABCG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PDXKchr2145139262+ABCG1chr2143645780+1.53E-101
PDXKchr2145139262+ABCG1chr2143645780+1.53E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDXK-ABCG1


check button Go to

FGviewer for the breakpoints of chr21:45139262-chr21:43645781

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCG1

P45844

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620). {ECO:0000269|PubMed:16702602, ECO:0000269|PubMed:17408620, ECO:0000269|PubMed:24576892}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015415_67325.0678.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:45139262chr21:43645781ENST0000034368701577_31725.0678.0DomainABC transporter
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015415_67311.0664.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:45139262chr21:43645781ENST0000034780001577_31711.0664.0DomainABC transporter
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015415_67314.0679.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:45139262chr21:43645781ENST0000036180201577_31714.0679.0DomainABC transporter
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015415_67314.0667.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:45139262chr21:43645781ENST0000039844901577_31714.0667.0DomainABC transporter
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116415_67316.0669.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:45139262chr21:43645781ENST0000039845711677_31716.0669.0DomainABC transporter
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015118_12525.0678.0Nucleotide bindingATP
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015118_12511.0664.0Nucleotide bindingATP
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015118_12514.0679.0Nucleotide bindingATP
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015118_12514.0667.0Nucleotide bindingATP
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116118_12516.0669.0Nucleotide bindingATP
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015446_45625.0678.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015478_50625.0678.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015526_53325.0678.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015556_56725.0678.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015587_64925.0678.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015670_67825.0678.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015446_45611.0664.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015478_50611.0664.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015526_53311.0664.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015556_56711.0664.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015587_64911.0664.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015670_67811.0664.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015446_45614.0679.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015478_50614.0679.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015526_53314.0679.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015556_56714.0679.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015587_64914.0679.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015670_67814.0679.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015446_45614.0667.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015478_50614.0667.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015526_53314.0667.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015556_56714.0667.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015587_64914.0667.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015670_67814.0667.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116446_45616.0669.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116478_50616.0669.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116526_53316.0669.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116556_56716.0669.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116587_64916.0669.0Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116670_67816.0669.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015427_44525.0678.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015457_47725.0678.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015507_52525.0678.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015534_55525.0678.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015568_58625.0678.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687015650_66925.0678.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015427_44511.0664.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015457_47711.0664.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015507_52511.0664.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015534_55511.0664.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015568_58611.0664.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800015650_66911.0664.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015427_44514.0679.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015457_47714.0679.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015507_52514.0679.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015534_55514.0679.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015568_58614.0679.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802015650_66914.0679.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015427_44514.0667.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015457_47714.0667.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015507_52514.0667.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015534_55514.0667.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015568_58614.0667.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449015650_66914.0667.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116427_44516.0669.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116457_47716.0669.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116507_52516.0669.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116534_55516.0669.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116568_58616.0669.0TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457116650_66916.0669.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDXKchr21:45139262chr21:43645781ENST00000291565+111150_15329.0313.0Nucleotide bindingATP
HgenePDXKchr21:45139262chr21:43645781ENST00000291565+111186_18729.0313.0Nucleotide bindingATP
HgenePDXKchr21:45139262chr21:43645781ENST00000291565+111226_22829.0313.0Nucleotide bindingATP
HgenePDXKchr21:45139262chr21:43645781ENST00000468090+110150_15329.0285.0Nucleotide bindingATP
HgenePDXKchr21:45139262chr21:43645781ENST00000468090+110186_18729.0285.0Nucleotide bindingATP
HgenePDXKchr21:45139262chr21:43645781ENST00000468090+110226_22829.0285.0Nucleotide bindingATP
HgenePDXKchr21:45139262chr21:43645781ENST00000291565+111234_23529.0313.0RegionPyridoxal 5'-phosphate binding
HgenePDXKchr21:45139262chr21:43645781ENST00000468090+110234_23529.0285.0RegionPyridoxal 5'-phosphate binding
TgeneABCG1chr21:45139262chr21:43645781ENST000003436870151_42625.0678.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST000003478000151_42611.0664.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST000003618020151_42614.0679.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST000003984490151_42614.0667.0Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST000003984571161_42616.0669.0Topological domainCytoplasmic


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Fusion Gene Sequence for PDXK-ABCG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000398081_ENST00000398457_TCGA-BL-A0C8-01A_PDXK_chr21_45139262_+_ABCG1_chr21_43645781_length(transcript)=3099nt_BP=288nt
GCGCGGAACTCGCGGGTTCGGAGCCGCCCGCTGAGGTCAGAAGGAGGCGTCTGCGCTGATCGGGTCCGCCGCGCGCCAGAGCCAGAGTCG
CAGCCGAGGGGAGCCGGGGCCGGAGCCCGAGCCCGAGCCGAGCCGGAGCCCGAGCGAGCGGCGGAGACCGTGCCCCCGCCTCGGCCCCGC
GCCGCCGCGGCCAGGCCCGGCATGGAGGAGGAGTGCCGGGTGCTCTCCATACAGAGCCACGTCATCCGCGGCTACGTGGGCAACCGGGCG
GCCACGTTCCCGCTGCAGAATGCCAGCAGTTACTCTGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCC
AGCAACATGGAGGCCACTGAGACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCC
TTGCCTCGGAGGGCAGCTGTGAACATTGAATTCAGGGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAG
ACCCTCCTGAAAGGAATTTCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATG
AACATCCTGGCTGGATACAGGGAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTG
TCCTGCTACATCATGCAGGATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAG
AAGGATGAAGGCAGAAGGGAAATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCA
GGTGGTCAGCGCAAGCGCCTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGAC
AGCGCCTCCTGCTTCCAGGTGGTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCC
AAACTCTTCGAGCTGTTCGACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTG
AGGGATTTGGGTCTGAACTGCCCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGT
CGGCTGGTGAGAGCGGTTCGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGG
CACCGGCCCTCTGAAGAGGACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAG
AGGACCTTCCTCAGCATCATGAGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTG
TACTTGGGGATCGGGAACGAAGCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTC
ATGCCTACTGTTCTGACATTTCCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTG
GCCAAGACCATGGCAGACGTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGAC
GCCGTGCGCTTTGTGCTGTTTGCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACG
TCCCTGCAGGTGGCCACTTTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCC
ACGTACCTACAGTGGATGTCCTACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGAT
CTGCACTGTGACATCGACGAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTG
GACTTCATCGTACTCGGGATTTTCTTCATCTCCCTCCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAAAAC
ACCTGAATGCCAGGAAACAGGAAGATTAGACACTGTGGCCGAGGGCACGTCTAGAATCGAGGAGGCAAGCCTGTGCCCGACCGACGACAC
AGAGACTCTTCTGATCCAACCCCTAGAACCGCGTTGGGTTTGTGGGTGTCTCGTGCTCAGCCACTCTGCCCAGCTGGGTTGGATCTTCTC
TCCATTCCCCTTTCTAGCTTTAACTAGGAAGATGTAGGCAGATTGGTGGTTTTTTTTTTTTTAACATACAGAATTTTAAATACCACAACT
GGGGCAGAATTTAAAGCTGCAACACAGCTGGTGATGAGAGGCTTCCTCAGTCCAGTCGCTCCTTAGCACCAGGCACCGTGGGTCCTGGAT
GGGGAACTGCAAGCAGCCTCTCAGCTGATGGCTGCACAGTCAGATGTCTGGTGGCAGAGAGTCCGAGCATGGAGCGATTCCATTTTATGA
CTGTTGTTTTTCACATTTTCATCTTTCTAAGGTGTGTCTCTTTTCCAATGAGAAGTCATTTTTGCAAGCCAAAAGTCGATCAATCGCATT
CATTTTAAGAAATTATACCTTTTTAGTACTTGCTGAAGAATGATTCAGGGTAAATCACATACTTTGTTTAGAGAGGCGAGGGGTTTAACC
GAGTCACCCAGCTGGTCTCATACATAGACAGCACTTGTGAAGGATTGAATGCAGGTTCCAGGTGGAGGGAAGACGTGGACACCATCTCCA
CTGAGCCATGCAGACATTTTTAAAAGCTATACAAAAAATTGTGAGAAGACATTGGCCAACTCTTTCAAAGTCTTTCTTTTTCCACGTGCT

>In-frame_ENST00000398081_ENST00000398457_TCGA-BL-A0C8-01A_PDXK_chr21_45139262_+_ABCG1_chr21_43645781_length(amino acids)=738AA_start in transcript=30_stop in transcript=2246
MRSEGGVCADRVRRAPEPESQPRGAGAGARARAEPEPERAAETVPPPRPRAAAARPGMEEECRVLSIQSHVIRGYVGNRAATFPLQNASS
YSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKF
NSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVK
EILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLY
VLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSS
MEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLE
MGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGP
VTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFI

--------------------------------------------------------------
>In-frame_ENST00000468090_ENST00000398457_TCGA-BL-A0C8-01A_PDXK_chr21_45139262_+_ABCG1_chr21_43645781_length(transcript)=3096nt_BP=285nt
CGGAACTCGCGGGTTCGGAGCCGCCCGCTGAGGTCAGAAGGAGGCGTCTGCGCTGATCGGGTCCGCCGCGCGCCAGAGCCAGAGTCGCAG
CCGAGGGGAGCCGGGGCCGGAGCCCGAGCCCGAGCCGAGCCGGAGCCCGAGCGAGCGGCGGAGACCGTGCCCCCGCCTCGGCCCCGCGCC
GCCGCGGCCAGGCCCGGCATGGAGGAGGAGTGCCGGGTGCTCTCCATACAGAGCCACGTCATCCGCGGCTACGTGGGCAACCGGGCGGCC
ACGTTCCCGCTGCAGAATGCCAGCAGTTACTCTGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGC
AACATGGAGGCCACTGAGACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCCTTG
CCTCGGAGGGCAGCTGTGAACATTGAATTCAGGGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACC
CTCCTGAAAGGAATTTCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATGAAC
ATCCTGGCTGGATACAGGGAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCC
TGCTACATCATGCAGGATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAGAAG
GATGAAGGCAGAAGGGAAATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGT
GGTCAGCGCAAGCGCCTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGACAGC
GCCTCCTGCTTCCAGGTGGTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAA
CTCTTCGAGCTGTTCGACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTGAGG
GATTTGGGTCTGAACTGCCCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGG
CTGGTGAGAGCGGTTCGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGGCAC
CGGCCCTCTGAAGAGGACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAGAGG
ACCTTCCTCAGCATCATGAGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTAC
TTGGGGATCGGGAACGAAGCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTCATG
CCTACTGTTCTGACATTTCCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCC
AAGACCATGGCAGACGTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGACGCC
GTGCGCTTTGTGCTGTTTGCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCC
CTGCAGGTGGCCACTTTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCCACG
TACCTACAGTGGATGTCCTACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTG
CACTGTGACATCGACGAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTGGAC
TTCATCGTACTCGGGATTTTCTTCATCTCCCTCCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAAAACACC
TGAATGCCAGGAAACAGGAAGATTAGACACTGTGGCCGAGGGCACGTCTAGAATCGAGGAGGCAAGCCTGTGCCCGACCGACGACACAGA
GACTCTTCTGATCCAACCCCTAGAACCGCGTTGGGTTTGTGGGTGTCTCGTGCTCAGCCACTCTGCCCAGCTGGGTTGGATCTTCTCTCC
ATTCCCCTTTCTAGCTTTAACTAGGAAGATGTAGGCAGATTGGTGGTTTTTTTTTTTTTAACATACAGAATTTTAAATACCACAACTGGG
GCAGAATTTAAAGCTGCAACACAGCTGGTGATGAGAGGCTTCCTCAGTCCAGTCGCTCCTTAGCACCAGGCACCGTGGGTCCTGGATGGG
GAACTGCAAGCAGCCTCTCAGCTGATGGCTGCACAGTCAGATGTCTGGTGGCAGAGAGTCCGAGCATGGAGCGATTCCATTTTATGACTG
TTGTTTTTCACATTTTCATCTTTCTAAGGTGTGTCTCTTTTCCAATGAGAAGTCATTTTTGCAAGCCAAAAGTCGATCAATCGCATTCAT
TTTAAGAAATTATACCTTTTTAGTACTTGCTGAAGAATGATTCAGGGTAAATCACATACTTTGTTTAGAGAGGCGAGGGGTTTAACCGAG
TCACCCAGCTGGTCTCATACATAGACAGCACTTGTGAAGGATTGAATGCAGGTTCCAGGTGGAGGGAAGACGTGGACACCATCTCCACTG
AGCCATGCAGACATTTTTAAAAGCTATACAAAAAATTGTGAGAAGACATTGGCCAACTCTTTCAAAGTCTTTCTTTTTCCACGTGCTTCT

>In-frame_ENST00000468090_ENST00000398457_TCGA-BL-A0C8-01A_PDXK_chr21_45139262_+_ABCG1_chr21_43645781_length(amino acids)=738AA_start in transcript=27_stop in transcript=2243
MRSEGGVCADRVRRAPEPESQPRGAGAGARARAEPEPERAAETVPPPRPRAAAARPGMEEECRVLSIQSHVIRGYVGNRAATFPLQNASS
YSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKF
NSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVK
EILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLY
VLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSS
MEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLE
MGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGP
VTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFI

--------------------------------------------------------------
>In-frame_ENST00000291565_ENST00000398457_TCGA-BL-A0C8-01A_PDXK_chr21_45139262_+_ABCG1_chr21_43645781_length(transcript)=3081nt_BP=270nt
CGGAGCCGCCCGCTGAGGTCAGAAGGAGGCGTCTGCGCTGATCGGGTCCGCCGCGCGCCAGAGCCAGAGTCGCAGCCGAGGGGAGCCGGG
GCCGGAGCCCGAGCCCGAGCCGAGCCGGAGCCCGAGCGAGCGGCGGAGACCGTGCCCCCGCCTCGGCCCCGCGCCGCCGCGGCCAGGCCC
GGCATGGAGGAGGAGTGCCGGGTGCTCTCCATACAGAGCCACGTCATCCGCGGCTACGTGGGCAACCGGGCGGCCACGTTCCCGCTGCAG
AATGCCAGCAGTTACTCTGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAACATGGAGGCCACT
GAGACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCCTTGCCTCGGAGGGCAGCT
GTGAACATTGAATTCAGGGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTCCTGAAAGGAATT
TCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATGAACATCCTGGCTGGATAC
AGGGAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGCTACATCATGCAG
GATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAGAAGGATGAAGGCAGAAGG
GAAATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGTCAGCGCAAGCGC
CTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGACAGCGCCTCCTGCTTCCAG
GTGGTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTCTTCGAGCTGTTC
GACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTGAGGGATTTGGGTCTGAAC
TGCCCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTGGTGAGAGCGGTT
CGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGGCACCGGCCCTCTGAAGAG
GACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATC
ATGAGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTACTTGGGGATCGGGAAC
GAAGCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACA
TTTCCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCCAAGACCATGGCAGAC
GTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTG
TTTGCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCCCTGCAGGTGGCCACT
TTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCCACGTACCTACAGTGGATG
TCCTACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTGCACTGTGACATCGAC
GAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTGGACTTCATCGTACTCGGG
ATTTTCTTCATCTCCCTCCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAAAACACCTGAATGCCAGGAAAC
AGGAAGATTAGACACTGTGGCCGAGGGCACGTCTAGAATCGAGGAGGCAAGCCTGTGCCCGACCGACGACACAGAGACTCTTCTGATCCA
ACCCCTAGAACCGCGTTGGGTTTGTGGGTGTCTCGTGCTCAGCCACTCTGCCCAGCTGGGTTGGATCTTCTCTCCATTCCCCTTTCTAGC
TTTAACTAGGAAGATGTAGGCAGATTGGTGGTTTTTTTTTTTTTAACATACAGAATTTTAAATACCACAACTGGGGCAGAATTTAAAGCT
GCAACACAGCTGGTGATGAGAGGCTTCCTCAGTCCAGTCGCTCCTTAGCACCAGGCACCGTGGGTCCTGGATGGGGAACTGCAAGCAGCC
TCTCAGCTGATGGCTGCACAGTCAGATGTCTGGTGGCAGAGAGTCCGAGCATGGAGCGATTCCATTTTATGACTGTTGTTTTTCACATTT
TCATCTTTCTAAGGTGTGTCTCTTTTCCAATGAGAAGTCATTTTTGCAAGCCAAAAGTCGATCAATCGCATTCATTTTAAGAAATTATAC
CTTTTTAGTACTTGCTGAAGAATGATTCAGGGTAAATCACATACTTTGTTTAGAGAGGCGAGGGGTTTAACCGAGTCACCCAGCTGGTCT
CATACATAGACAGCACTTGTGAAGGATTGAATGCAGGTTCCAGGTGGAGGGAAGACGTGGACACCATCTCCACTGAGCCATGCAGACATT
TTTAAAAGCTATACAAAAAATTGTGAGAAGACATTGGCCAACTCTTTCAAAGTCTTTCTTTTTCCACGTGCTTCTTATTTTAAGCGAAAT

>In-frame_ENST00000291565_ENST00000398457_TCGA-BL-A0C8-01A_PDXK_chr21_45139262_+_ABCG1_chr21_43645781_length(amino acids)=738AA_start in transcript=12_stop in transcript=2228
MRSEGGVCADRVRRAPEPESQPRGAGAGARARAEPEPERAAETVPPPRPRAAAARPGMEEECRVLSIQSHVIRGYVGNRAATFPLQNASS
YSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKF
NSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVK
EILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLY
VLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSS
MEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLE
MGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGP
VTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFI

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Fusion Gene PPI Analysis for PDXK-ABCG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDXK-ABCG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDXK-ABCG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDXKC0038220Status Epilepticus1CTD_human
HgenePDXKC0270823Petit mal status1CTD_human
HgenePDXKC0311335Grand Mal Status Epilepticus1CTD_human
HgenePDXKC0393734Complex Partial Status Epilepticus1CTD_human
HgenePDXKC0751522Status Epilepticus, Subclinical1CTD_human
HgenePDXKC0751523Non-Convulsive Status Epilepticus1CTD_human
HgenePDXKC0751524Simple Partial Status Epilepticus1CTD_human
TgeneABCG1C0009402Colorectal Carcinoma1CTD_human
TgeneABCG1C0009404Colorectal Neoplasms1CTD_human
TgeneABCG1C0022661Kidney Failure, Chronic1CTD_human
TgeneABCG1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneABCG1C0043094Weight Gain1CTD_human