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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF2-SSR2 (FusionGDB2 ID:6374)

Fusion Gene Summary for ARHGEF2-SSR2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF2-SSR2
Fusion gene ID: 6374
HgeneTgene
Gene symbol

ARHGEF2

SSR2

Gene ID

9181

6746

Gene nameRho/Rac guanine nucleotide exchange factor 2signal sequence receptor subunit 2
SynonymsGEF|GEF-H1|GEFH1|LFP40|Lfc|NEDMHM|P40HSD25|TLAP|TRAP-BETA|TRAPB
Cytomap

1q22

1q22

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 2Rho/Rac guanine nucleotide exchange factor (GEF) 2guanine nucleotide exchange factor H1microtubule-regulated Rho-GEFproliferating cell nucleolar antigen p40translocon-associated protein subunit betaSSR-betasignal sequence receptor subunit betasignal sequence receptor, beta (translocon-associated protein beta)translocon-associated protein beta
Modification date2020031320200320
UniProtAcc

Q92974

.
Ensembl transtripts involved in fusion geneENST00000368315, ENST00000313695, 
ENST00000361247, ENST00000368316, 
ENST00000462460, ENST00000477754, 
ENST00000313667, 		ENST00000295702, 
ENST00000529008, ENST00000496742, 
ENST00000480567, 
Fusion gene scores* DoF score12 X 15 X 10=18008 X 9 X 9=648
# samples 1613
** MAII scorelog2(16/1800*10)=-3.49185309632968
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF2 [Title/Abstract] AND SSR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF2(155932724)-SSR2(155981678), # samples:2
ARHGEF2(155921274)-SSR2(155979441), # samples:2
Anticipated loss of major functional domain due to fusion event.ARHGEF2-SSR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARHGEF2-SSR2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF2

GO:0032755

positive regulation of interleukin-6 production

21887730

HgeneARHGEF2

GO:0032760

positive regulation of tumor necrosis factor production

21887730

HgeneARHGEF2

GO:0045666

positive regulation of neuron differentiation

28453519

HgeneARHGEF2

GO:0045944

positive regulation of transcription by RNA polymerase II

21887730

HgeneARHGEF2

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

21887730

HgeneARHGEF2

GO:0051092

positive regulation of NF-kappaB transcription factor activity

19043560|21887730

HgeneARHGEF2

GO:0055059

asymmetric neuroblast division

28453519

HgeneARHGEF2

GO:0071225

cellular response to muramyl dipeptide

21887730


check buttonFusion gene breakpoints across ARHGEF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SSR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A256-01AARHGEF2chr1

155932724

-SSR2chr1

155981678

-
ChimerDB4UCECTCGA-D1-A3JQ-01AARHGEF2chr1

155927504

-SSR2chr1

155979441

-
ChimerDB4UCSTCGA-N6-A4VCARHGEF2chr1

155921274

-SSR2chr1

155979441

-
ChimerDB4BRCATCGA-AR-A256-01AARHGEF2chr1

155932724

-SSR2chr1

155981678

-
ChimerDB4UCSTCGA-N6-A4VC-01AARHGEF2chr1

155921274

-SSR2chr1

155979441

-


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Fusion Gene ORF analysis for ARHGEF2-SSR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000368315ENST00000295702ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000368315ENST00000529008ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000368315ENST00000496742ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000368315ENST00000480567ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
In-frameENST00000313695ENST00000295702ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000313695ENST00000529008ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000313695ENST00000496742ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000313695ENST00000480567ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
In-frameENST00000361247ENST00000295702ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000361247ENST00000529008ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000361247ENST00000496742ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000361247ENST00000480567ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
Frame-shiftENST00000368316ENST00000295702ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000368316ENST00000529008ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000368316ENST00000496742ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000368316ENST00000480567ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
Frame-shiftENST00000462460ENST00000295702ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000462460ENST00000529008ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000462460ENST00000496742ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000462460ENST00000480567ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
intron-3CDSENST00000477754ENST00000295702ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
intron-intronENST00000477754ENST00000529008ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
intron-intronENST00000477754ENST00000496742ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
intron-intronENST00000477754ENST00000480567ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
In-frameENST00000313667ENST00000295702ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000313667ENST00000529008ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000313667ENST00000496742ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
5CDS-intronENST00000313667ENST00000480567ARHGEF2chr1

155932724

-SSR2chr1

155981678

-
Frame-shiftENST00000368315ENST00000295702ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000368315ENST00000529008ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
In-frameENST00000368315ENST00000496742ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
In-frameENST00000368315ENST00000480567ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000313695ENST00000295702ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000313695ENST00000529008ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
In-frameENST00000313695ENST00000496742ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
In-frameENST00000313695ENST00000480567ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000361247ENST00000295702ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000361247ENST00000529008ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
In-frameENST00000361247ENST00000496742ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
In-frameENST00000361247ENST00000480567ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
In-frameENST00000368316ENST00000295702ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000368316ENST00000529008ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000368316ENST00000496742ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000368316ENST00000480567ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
In-frameENST00000462460ENST00000295702ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000462460ENST00000529008ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000462460ENST00000496742ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000462460ENST00000480567ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
intron-3CDSENST00000477754ENST00000295702ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
intron-3CDSENST00000477754ENST00000529008ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
intron-3CDSENST00000477754ENST00000496742ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
intron-3CDSENST00000477754ENST00000480567ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000313667ENST00000295702ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000313667ENST00000529008ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
In-frameENST00000313667ENST00000496742ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
In-frameENST00000313667ENST00000480567ARHGEF2chr1

155927504

-SSR2chr1

155979441

-
Frame-shiftENST00000368315ENST00000295702ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
In-frameENST00000368315ENST00000529008ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000368315ENST00000496742ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000368315ENST00000480567ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000313695ENST00000295702ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
In-frameENST00000313695ENST00000529008ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000313695ENST00000496742ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000313695ENST00000480567ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000361247ENST00000295702ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
In-frameENST00000361247ENST00000529008ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000361247ENST00000496742ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000361247ENST00000480567ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000368316ENST00000295702ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000368316ENST00000529008ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
In-frameENST00000368316ENST00000496742ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
In-frameENST00000368316ENST00000480567ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000462460ENST00000295702ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000462460ENST00000529008ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
In-frameENST00000462460ENST00000496742ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
In-frameENST00000462460ENST00000480567ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
intron-3CDSENST00000477754ENST00000295702ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
intron-3CDSENST00000477754ENST00000529008ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
intron-3CDSENST00000477754ENST00000496742ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
intron-3CDSENST00000477754ENST00000480567ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000313667ENST00000295702ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
In-frameENST00000313667ENST00000529008ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000313667ENST00000496742ARHGEF2chr1

155921274

-SSR2chr1

155979441

-
Frame-shiftENST00000313667ENST00000480567ARHGEF2chr1

155921274

-SSR2chr1

155979441

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARHGEF2-SSR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGEF2-SSR2


check button Go to

FGviewer for the breakpoints of chr1:155932724-chr1:155981678

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF2

Q92974

.
FUNCTION: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000313667-1922587_611752.0986.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000313695-1922587_611725.0959.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000361247-1922587_611753.0987.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000368316-2326587_611725.0959.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000313667-1922235_432752.0986.0DomainDH
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000313667-1922472_571752.0986.0DomainPH
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000313695-1922235_432725.0959.0DomainDH
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000313695-1922472_571725.0959.0DomainPH
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000361247-1922235_432753.0987.0DomainDH
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000361247-1922472_571753.0987.0DomainPH
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000368316-2326235_432725.0959.0DomainDH
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000368316-2326472_571725.0959.0DomainPH
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000313667-1322235_432570.6666666666666986.0DomainDH
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000313667-1322472_571570.6666666666666986.0DomainPH
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000313695-1322235_432543.6666666666666959.0DomainDH
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000361247-1322235_432571.6666666666666987.0DomainDH
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000361247-1322472_571571.6666666666666987.0DomainPH
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000368316-1726235_432543.6666666666666959.0DomainDH
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000313667-192239_86752.0986.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000313695-192239_86725.0959.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000361247-192239_86753.0987.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000368316-232639_86725.0959.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000313667-132239_86570.6666666666666986.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000313695-132239_86543.6666666666666959.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000361247-132239_86571.6666666666666987.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000368316-172639_86543.6666666666666959.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000313667-82239_86324.0986.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000313695-82239_86297.0959.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000361247-82239_86325.0987.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000368316-122639_86297.0959.0Zinc fingerPhorbol-ester/DAG-type
TgeneSSR2chr1:155921274chr1:155979441ENST0000029570246170_183147.0184.0Topological domainCytoplasmic
TgeneSSR2chr1:155921274chr1:155979441ENST0000048056746170_183147.0184.0Topological domainCytoplasmic
TgeneSSR2chr1:155927504chr1:155979441ENST0000029570246170_183147.0184.0Topological domainCytoplasmic
TgeneSSR2chr1:155927504chr1:155979441ENST0000048056746170_183147.0184.0Topological domainCytoplasmic
TgeneSSR2chr1:155932724chr1:155981678ENST0000029570236170_183121.0184.0Topological domainCytoplasmic
TgeneSSR2chr1:155932724chr1:155981678ENST0000048056736170_183121.0184.0Topological domainCytoplasmic
TgeneSSR2chr1:155921274chr1:155979441ENST0000029570246150_169147.0184.0TransmembraneHelical
TgeneSSR2chr1:155921274chr1:155979441ENST0000048056746150_169147.0184.0TransmembraneHelical
TgeneSSR2chr1:155927504chr1:155979441ENST0000029570246150_169147.0184.0TransmembraneHelical
TgeneSSR2chr1:155927504chr1:155979441ENST0000048056746150_169147.0184.0TransmembraneHelical
TgeneSSR2chr1:155932724chr1:155981678ENST0000029570236150_169121.0184.0TransmembraneHelical
TgeneSSR2chr1:155932724chr1:155981678ENST0000048056736150_169121.0184.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000313667-1922798_867752.0986.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000313695-1922798_867725.0959.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000361247-1922798_867753.0987.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000368316-2326798_867725.0959.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000313667-1322587_611570.6666666666666986.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000313667-1322798_867570.6666666666666986.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000313695-1322587_611543.6666666666666959.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000313695-1322798_867543.6666666666666959.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000361247-1322587_611571.6666666666666987.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000361247-1322798_867571.6666666666666987.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000368316-1726587_611543.6666666666666959.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000368316-1726798_867543.6666666666666959.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000313667-822587_611324.0986.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000313667-822798_867324.0986.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000313695-822587_611297.0959.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000313695-822798_867297.0959.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000361247-822587_611325.0987.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000361247-822798_867325.0987.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000368316-1226587_611297.0959.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000368316-1226798_867297.0959.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000313695-1322472_571543.6666666666666959.0DomainPH
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000368316-1726472_571543.6666666666666959.0DomainPH
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000313667-822235_432324.0986.0DomainDH
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000313667-822472_571324.0986.0DomainPH
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000313695-822235_432297.0959.0DomainDH
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000313695-822472_571297.0959.0DomainPH
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000361247-822235_432325.0987.0DomainDH
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000361247-822472_571325.0987.0DomainPH
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000368316-1226235_432297.0959.0DomainDH
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000368316-1226472_571297.0959.0DomainPH
TgeneSSR2chr1:155921274chr1:155979441ENST000002957024618_149147.0184.0Topological domainLumenal
TgeneSSR2chr1:155921274chr1:155979441ENST000004805674618_149147.0184.0Topological domainLumenal
TgeneSSR2chr1:155927504chr1:155979441ENST000002957024618_149147.0184.0Topological domainLumenal
TgeneSSR2chr1:155927504chr1:155979441ENST000004805674618_149147.0184.0Topological domainLumenal
TgeneSSR2chr1:155932724chr1:155981678ENST000002957023618_149121.0184.0Topological domainLumenal
TgeneSSR2chr1:155932724chr1:155981678ENST000004805673618_149121.0184.0Topological domainLumenal


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Fusion Gene Sequence for ARHGEF2-SSR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARHGEF2-SSR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000313667-1922131_161752.0986.0DYNLT1
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000313695-1922131_161725.0959.0DYNLT1
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000361247-1922131_161753.0987.0DYNLT1
HgeneARHGEF2chr1:155921274chr1:155979441ENST00000368316-2326131_161725.0959.0DYNLT1
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000313667-1322131_161570.6666666666666986.0DYNLT1
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000313695-1322131_161543.6666666666666959.0DYNLT1
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000361247-1322131_161571.6666666666666987.0DYNLT1
HgeneARHGEF2chr1:155927504chr1:155979441ENST00000368316-1726131_161543.6666666666666959.0DYNLT1
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000313667-822131_161324.0986.0DYNLT1
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000313695-822131_161297.0959.0DYNLT1
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000361247-822131_161325.0987.0DYNLT1
HgeneARHGEF2chr1:155932724chr1:155981678ENST00000368316-1226131_161297.0959.0DYNLT1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF2-SSR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF2-SSR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGEF2C4479613NEURODEVELOPMENTAL DISORDER WITH MIDBRAIN AND HINDBRAIN MALFORMATIONS1GENOMICS_ENGLAND
TgeneSSR2C0033578Prostatic Neoplasms1CTD_human
TgeneSSR2C0376358Malignant neoplasm of prostate1CTD_human