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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDZRN3-PDZRN3 (FusionGDB2 ID:63769)

Fusion Gene Summary for PDZRN3-PDZRN3

check button Fusion gene summary
Fusion gene informationFusion gene name: PDZRN3-PDZRN3
Fusion gene ID: 63769
HgeneTgene
Gene symbol

PDZRN3

PDZRN3

Gene ID

23024

23024

Gene namePDZ domain containing ring finger 3PDZ domain containing ring finger 3
SynonymsLNX3|SEMACAP3|SEMCAP3LNX3|SEMACAP3|SEMCAP3
Cytomap

3p13

3p13

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase PDZRN3RING-type E3 ubiquitin transferase PDZRN3ligand of Numb protein X 3likely ortholog of mouse semaF cytoplasmic domain associated protein 3semaphorin cytoplasmic domain-associated protein 3E3 ubiquitin-protein ligase PDZRN3RING-type E3 ubiquitin transferase PDZRN3ligand of Numb protein X 3likely ortholog of mouse semaF cytoplasmic domain associated protein 3semaphorin cytoplasmic domain-associated protein 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263666, ENST00000466780, 
ENST00000308537, ENST00000462146, 
ENST00000535920, ENST00000479530, 
ENST00000466348, 		ENST00000263666, 
ENST00000466780, ENST00000308537, 
ENST00000462146, ENST00000535920, 
ENST00000479530, ENST00000466348, 
Fusion gene scores* DoF score10 X 6 X 6=3603 X 5 X 3=45
# samples 125
** MAII scorelog2(12/360*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PDZRN3 [Title/Abstract] AND PDZRN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDZRN3(73624420)-PDZRN3(73624508), # samples:1
PDZRN3(73570431)-PDZRN3(73569050), # samples:1
PDZRN3(73483145)-PDZRN3(73439018), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PDZRN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PDZRN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW841091PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
ChiTaRS5.0N/ABI033898PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
ChiTaRS5.0N/AW28326PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-


Top

Fusion Gene ORF analysis for PDZRN3-PDZRN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000263666ENST00000263666PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000263666ENST00000466780PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000263666ENST00000308537PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000263666ENST00000462146PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000263666ENST00000535920PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000263666ENST00000479530PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000263666ENST00000466348PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466780ENST00000263666PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466780ENST00000466780PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466780ENST00000308537PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466780ENST00000462146PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466780ENST00000535920PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466780ENST00000479530PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466780ENST00000466348PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000308537ENST00000263666PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000308537ENST00000466780PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000308537ENST00000308537PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000308537ENST00000462146PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000308537ENST00000535920PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000308537ENST00000479530PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000308537ENST00000466348PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000462146ENST00000263666PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000462146ENST00000466780PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000462146ENST00000308537PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000462146ENST00000462146PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000462146ENST00000535920PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000462146ENST00000479530PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000462146ENST00000466348PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000535920ENST00000263666PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000535920ENST00000466780PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000535920ENST00000308537PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000535920ENST00000462146PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000535920ENST00000535920PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000535920ENST00000479530PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000535920ENST00000466348PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000479530ENST00000263666PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000479530ENST00000466780PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000479530ENST00000308537PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000479530ENST00000462146PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000479530ENST00000535920PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000479530ENST00000479530PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000479530ENST00000466348PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466348ENST00000263666PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466348ENST00000466780PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466348ENST00000308537PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466348ENST00000462146PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466348ENST00000535920PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466348ENST00000479530PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000466348ENST00000466348PDZRN3chr3

73624420

-PDZRN3chr3

73624508

+
intron-intronENST00000263666ENST00000263666PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000263666ENST00000466780PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000263666ENST00000308537PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000263666ENST00000462146PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000263666ENST00000535920PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000263666ENST00000479530PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000263666ENST00000466348PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466780ENST00000263666PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466780ENST00000466780PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466780ENST00000308537PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466780ENST00000462146PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466780ENST00000535920PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466780ENST00000479530PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466780ENST00000466348PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000308537ENST00000263666PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000308537ENST00000466780PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000308537ENST00000308537PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000308537ENST00000462146PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000308537ENST00000535920PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000308537ENST00000479530PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000308537ENST00000466348PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000462146ENST00000263666PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000462146ENST00000466780PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000462146ENST00000308537PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000462146ENST00000462146PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000462146ENST00000535920PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000462146ENST00000479530PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000462146ENST00000466348PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000535920ENST00000263666PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000535920ENST00000466780PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000535920ENST00000308537PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000535920ENST00000462146PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000535920ENST00000535920PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000535920ENST00000479530PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000535920ENST00000466348PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000479530ENST00000263666PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000479530ENST00000466780PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000479530ENST00000308537PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000479530ENST00000462146PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000479530ENST00000535920PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000479530ENST00000479530PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000479530ENST00000466348PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466348ENST00000263666PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466348ENST00000466780PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466348ENST00000308537PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466348ENST00000462146PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466348ENST00000535920PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466348ENST00000479530PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-intronENST00000466348ENST00000466348PDZRN3chr3

73570431

+PDZRN3chr3

73569050

-
intron-3CDSENST00000263666ENST00000263666PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000263666ENST00000466780PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000263666ENST00000308537PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000263666ENST00000462146PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000263666ENST00000535920PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000263666ENST00000479530PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-5UTRENST00000263666ENST00000466348PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000466780ENST00000263666PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000466780ENST00000466780PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000466780ENST00000308537PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000466780ENST00000462146PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000466780ENST00000535920PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000466780ENST00000479530PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-5UTRENST00000466780ENST00000466348PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000308537ENST00000263666PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000308537ENST00000466780PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000308537ENST00000308537PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000308537ENST00000462146PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000308537ENST00000535920PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000308537ENST00000479530PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-5UTRENST00000308537ENST00000466348PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000462146ENST00000263666PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000462146ENST00000466780PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000462146ENST00000308537PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000462146ENST00000462146PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000462146ENST00000535920PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000462146ENST00000479530PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-5UTRENST00000462146ENST00000466348PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000535920ENST00000263666PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000535920ENST00000466780PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000535920ENST00000308537PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000535920ENST00000462146PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000535920ENST00000535920PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000535920ENST00000479530PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-5UTRENST00000535920ENST00000466348PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000479530ENST00000263666PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000479530ENST00000466780PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000479530ENST00000308537PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000479530ENST00000462146PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000479530ENST00000535920PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000479530ENST00000479530PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-5UTRENST00000479530ENST00000466348PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000466348ENST00000263666PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-3CDSENST00000466348ENST00000466780PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000466348ENST00000308537PDZRN3chr3

73483145

+PDZRN3chr3

73439018

-
intron-intronENST00000466348ENST00000462146PDZRN3chr3

73483145

+PDZRN3chr3

73439018

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intron-intronENST00000466348ENST00000535920PDZRN3chr3

73483145

+PDZRN3chr3

73439018

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intron-intronENST00000466348ENST00000479530PDZRN3chr3

73483145

+PDZRN3chr3

73439018

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intron-5UTRENST00000466348ENST00000466348PDZRN3chr3

73483145

+PDZRN3chr3

73439018

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check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PDZRN3-PDZRN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PDZRN3-PDZRN3


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PDZRN3-PDZRN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PDZRN3-PDZRN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDZRN3-PDZRN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDZRN3-PDZRN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDZRN3C0023893Liver Cirrhosis, Experimental1CTD_human
TgenePDZRN3C0023893Liver Cirrhosis, Experimental1CTD_human