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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PEMT-PRKCA (FusionGDB2 ID:63866) |
Fusion Gene Summary for PEMT-PRKCA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PEMT-PRKCA | Fusion gene ID: 63866 | Hgene | Tgene | Gene symbol | PEMT | PRKCA | Gene ID | 10400 | 5578 |
| Gene name | phosphatidylethanolamine N-methyltransferase | protein kinase C alpha | |
| Synonyms | PEAMT|PEMPT|PEMT2|PLMT|PNMT | AAG6|PKC-alpha|PKCA|PKCI+/-|PKCalpha|PRKACA | |
| Cytomap | 17p11.2 | 17q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphatidylethanolamine N-methyltransferasephospholipid methyltransferase | protein kinase C alpha typePKC-Aaging-associated gene 6 | |
| Modification date | 20200320 | 20200327 | |
| UniProtAcc | . | PICK1 | |
| Ensembl transtripts involved in fusion gene | ENST00000395782, ENST00000395783, ENST00000435340, ENST00000255389, ENST00000395781, ENST00000484838, | ENST00000413366, ENST00000583361, | |
| Fusion gene scores | * DoF score | 11 X 7 X 6=462 | 26 X 21 X 9=4914 |
| # samples | 11 | 29 | |
| ** MAII score | log2(11/462*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(29/4914*10)=-4.08277305234723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PEMT [Title/Abstract] AND PRKCA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PEMT(17480234)-PRKCA(64637473), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | PEMT-PRKCA seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PEMT-PRKCA seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. PEMT-PRKCA seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PEMT-PRKCA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. PEMT-PRKCA seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PEMT-PRKCA seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRKCA | GO:0006468 | protein phosphorylation | 10770950 |
| Tgene | PRKCA | GO:0035408 | histone H3-T6 phosphorylation | 20228790 |
| Tgene | PRKCA | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 20011604 |
| Tgene | PRKCA | GO:0090330 | regulation of platelet aggregation | 12724315 |
| Fusion gene breakpoints across PEMT (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across PRKCA (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-C8-A135-01A | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
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Fusion Gene ORF analysis for PEMT-PRKCA |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000395782 | ENST00000413366 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
| 5CDS-intron | ENST00000395782 | ENST00000583361 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
| Frame-shift | ENST00000395783 | ENST00000413366 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
| 5CDS-intron | ENST00000395783 | ENST00000583361 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
| In-frame | ENST00000435340 | ENST00000413366 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
| 5CDS-intron | ENST00000435340 | ENST00000583361 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
| In-frame | ENST00000255389 | ENST00000413366 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
| 5CDS-intron | ENST00000255389 | ENST00000583361 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
| In-frame | ENST00000395781 | ENST00000413366 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
| 5CDS-intron | ENST00000395781 | ENST00000583361 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
| intron-3CDS | ENST00000484838 | ENST00000413366 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
| intron-intron | ENST00000484838 | ENST00000583361 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000435340 | PEMT | chr17 | 17480234 | - | ENST00000413366 | PRKCA | chr17 | 64637473 | + | 8628 | 191 | 53 | 1921 | 622 |
| ENST00000255389 | PEMT | chr17 | 17480234 | - | ENST00000413366 | PRKCA | chr17 | 64637473 | + | 8715 | 278 | 74 | 2008 | 644 |
| ENST00000395781 | PEMT | chr17 | 17480234 | - | ENST00000413366 | PRKCA | chr17 | 64637473 | + | 8723 | 286 | 82 | 2016 | 644 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000435340 | ENST00000413366 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + | 0.000448029 | 0.99955195 |
| ENST00000255389 | ENST00000413366 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + | 0.000484822 | 0.9995152 |
| ENST00000395781 | ENST00000413366 | PEMT | chr17 | 17480234 | - | PRKCA | chr17 | 64637473 | + | 0.000478671 | 0.9995214 |
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Fusion Genomic Features for PEMT-PRKCA |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| PEMT | chr17 | 17480233 | - | PRKCA | chr17 | 64637472 | + | 1.89E-08 | 1 |
| PEMT | chr17 | 17480233 | - | PRKCA | chr17 | 64637472 | + | 1.89E-08 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PEMT-PRKCA |
| Go to FGviewer for the breakpoints of chr17:17480234-chr17:64637473 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | PRKCA |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | 415 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000255389 | - | 2 | 7 | 13_33 | 68.0 | 237.0 | Intramembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395781 | - | 2 | 8 | 13_33 | 68.0 | 233.0 | Intramembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395782 | - | 2 | 7 | 13_33 | 31.0 | 200.0 | Intramembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395783 | - | 2 | 7 | 13_33 | 31.0 | 200.0 | Intramembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000255389 | - | 2 | 7 | 1_12 | 68.0 | 237.0 | Topological domain | Lumenal |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000255389 | - | 2 | 7 | 34_45 | 68.0 | 237.0 | Topological domain | Lumenal |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395781 | - | 2 | 8 | 1_12 | 68.0 | 233.0 | Topological domain | Lumenal |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395781 | - | 2 | 8 | 34_45 | 68.0 | 233.0 | Topological domain | Lumenal |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395782 | - | 2 | 7 | 1_12 | 31.0 | 200.0 | Topological domain | Lumenal |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395783 | - | 2 | 7 | 1_12 | 31.0 | 200.0 | Topological domain | Lumenal |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000255389 | - | 2 | 7 | 46_66 | 68.0 | 237.0 | Transmembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395781 | - | 2 | 8 | 46_66 | 68.0 | 233.0 | Transmembrane | Helical |
| Tgene | PRKCA | chr17:17480234 | chr17:64637473 | ENST00000413366 | 2 | 17 | 158_275 | 96.0 | 673.0 | Domain | C2 | |
| Tgene | PRKCA | chr17:17480234 | chr17:64637473 | ENST00000413366 | 2 | 17 | 339_597 | 96.0 | 673.0 | Domain | Protein kinase | |
| Tgene | PRKCA | chr17:17480234 | chr17:64637473 | ENST00000413366 | 2 | 17 | 598_668 | 96.0 | 673.0 | Domain | AGC-kinase C-terminal | |
| Tgene | PRKCA | chr17:17480234 | chr17:64637473 | ENST00000413366 | 2 | 17 | 345_353 | 96.0 | 673.0 | Nucleotide binding | ATP | |
| Tgene | PRKCA | chr17:17480234 | chr17:64637473 | ENST00000413366 | 2 | 17 | 101_151 | 96.0 | 673.0 | Zinc finger | Phorbol-ester/DAG-type 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000255389 | - | 2 | 7 | 180_181 | 68.0 | 237.0 | Region | S-adenosyl-L-methionine binding |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000255389 | - | 2 | 7 | 98_100 | 68.0 | 237.0 | Region | S-adenosyl-L-methionine binding |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395781 | - | 2 | 8 | 180_181 | 68.0 | 233.0 | Region | S-adenosyl-L-methionine binding |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395781 | - | 2 | 8 | 98_100 | 68.0 | 233.0 | Region | S-adenosyl-L-methionine binding |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395782 | - | 2 | 7 | 180_181 | 31.0 | 200.0 | Region | S-adenosyl-L-methionine binding |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395782 | - | 2 | 7 | 98_100 | 31.0 | 200.0 | Region | S-adenosyl-L-methionine binding |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395783 | - | 2 | 7 | 180_181 | 31.0 | 200.0 | Region | S-adenosyl-L-methionine binding |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395783 | - | 2 | 7 | 98_100 | 31.0 | 200.0 | Region | S-adenosyl-L-methionine binding |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000255389 | - | 2 | 7 | 115_157 | 68.0 | 237.0 | Topological domain | Lumenal |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000255389 | - | 2 | 7 | 179_199 | 68.0 | 237.0 | Topological domain | Cytoplasmic |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000255389 | - | 2 | 7 | 67_93 | 68.0 | 237.0 | Topological domain | Cytoplasmic |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395781 | - | 2 | 8 | 115_157 | 68.0 | 233.0 | Topological domain | Lumenal |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395781 | - | 2 | 8 | 179_199 | 68.0 | 233.0 | Topological domain | Cytoplasmic |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395781 | - | 2 | 8 | 67_93 | 68.0 | 233.0 | Topological domain | Cytoplasmic |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395782 | - | 2 | 7 | 115_157 | 31.0 | 200.0 | Topological domain | Lumenal |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395782 | - | 2 | 7 | 179_199 | 31.0 | 200.0 | Topological domain | Cytoplasmic |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395782 | - | 2 | 7 | 34_45 | 31.0 | 200.0 | Topological domain | Lumenal |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395782 | - | 2 | 7 | 67_93 | 31.0 | 200.0 | Topological domain | Cytoplasmic |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395783 | - | 2 | 7 | 115_157 | 31.0 | 200.0 | Topological domain | Lumenal |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395783 | - | 2 | 7 | 179_199 | 31.0 | 200.0 | Topological domain | Cytoplasmic |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395783 | - | 2 | 7 | 34_45 | 31.0 | 200.0 | Topological domain | Lumenal |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395783 | - | 2 | 7 | 67_93 | 31.0 | 200.0 | Topological domain | Cytoplasmic |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000255389 | - | 2 | 7 | 158_178 | 68.0 | 237.0 | Transmembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000255389 | - | 2 | 7 | 94_114 | 68.0 | 237.0 | Transmembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395781 | - | 2 | 8 | 158_178 | 68.0 | 233.0 | Transmembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395781 | - | 2 | 8 | 94_114 | 68.0 | 233.0 | Transmembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395782 | - | 2 | 7 | 158_178 | 31.0 | 200.0 | Transmembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395782 | - | 2 | 7 | 46_66 | 31.0 | 200.0 | Transmembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395782 | - | 2 | 7 | 94_114 | 31.0 | 200.0 | Transmembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395783 | - | 2 | 7 | 158_178 | 31.0 | 200.0 | Transmembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395783 | - | 2 | 7 | 46_66 | 31.0 | 200.0 | Transmembrane | Helical |
| Hgene | PEMT | chr17:17480234 | chr17:64637473 | ENST00000395783 | - | 2 | 7 | 94_114 | 31.0 | 200.0 | Transmembrane | Helical |
| Tgene | PRKCA | chr17:17480234 | chr17:64637473 | ENST00000413366 | 2 | 17 | 36_86 | 96.0 | 673.0 | Zinc finger | Phorbol-ester/DAG-type 1 |
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Fusion Gene Sequence for PEMT-PRKCA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000435340_ENST00000413366_TCGA-C8-A135-01A_PEMT_chr17_17480234_-_PRKCA_chr17_64637473_length(transcript)=8628nt_BP=191nt GGGGCGCGTGGCTGCAGCGGGGCCCGCGTGGTGCCTCCTGAGGCGGCCCCCGGATGAAGAGATCTGGGAACCCGGGAGCCGAGGCAGACT TCTGCGTTATGACCCGGCTGCTGGGCTACGTGGACCCCCTGGATCCCAGCTTTGTGGCTGCCGTCATCACCATCACCTTCAATCCGCTCT ACTGGAATGTGGACCCCAGGAGCAAGCACAAGTTCAAAATCCACACTTACGGAAGCCCCACCTTCTGCGATCACTGTGGGTCACTGCTCT ATGGACTTATCCATCAAGGGATGAAATGTGACACCTGCGATATGAACGTTCACAAGCAATGCGTCATCAATGTCCCCAGCCTCTGCGGAA TGGATCACACTGAGAAGAGGGGGCGGATTTACCTAAAGGCTGAGGTTGCTGATGAAAAGCTCCATGTCACAGTACGAGATGCAAAAAATC TAATCCCTATGGATCCAAACGGGCTTTCAGATCCTTATGTGAAGCTGAAACTTATTCCTGATCCCAAGAATGAAAGCAAGCAAAAAACCA AAACCATCCGCTCCACACTAAATCCGCAGTGGAATGAGTCCTTTACATTCAAATTGAAACCTTCAGACAAAGACCGACGACTGTCTGTAG AAATCTGGGACTGGGATCGAACAACAAGGAATGACTTCATGGGATCCCTTTCCTTTGGAGTTTCGGAGCTGATGAAGATGCCGGCCAGTG GATGGTACAAGTTGCTTAACCAAGAAGAAGGTGAGTACTACAACGTACCCATTCCGGAAGGGGACGAGGAAGGAAACATGGAACTCAGGC AGAAATTCGAGAAAGCCAAACTTGGCCCTGCTGGCAACAAAGTCATCAGTCCCTCTGAAGACAGGAAACAACCTTCCAACAACCTTGACC GAGTGAAACTCACGGACTTCAATTTCCTCATGGTGTTGGGAAAGGGGAGTTTTGGAAAGGTGATGCTTGCCGACAGGAAGGGCACAGAAG AACTGTATGCAATCAAAATCCTGAAGAAGGATGTGGTGATTCAGGATGATGACGTGGAGTGCACCATGGTAGAAAAGCGAGTCTTGGCCC TGCTTGACAAACCCCCGTTCTTGACGCAGCTGCACTCCTGCTTCCAGACAGTGGATCGGCTGTACTTCGTCATGGAATATGTCAACGGTG GGGACCTCATGTACCACATTCAGCAAGTAGGAAAATTTAAGGAACCACAAGCAGTATTCTATGCGGCAGAGATTTCCATCGGATTGTTCT TTCTTCATAAAAGAGGAATCATTTATAGGGATCTGAAGTTAGATAACGTCATGTTGGATTCAGAAGGACATATCAAAATTGCTGACTTTG GGATGTGCAAGGAACACATGATGGATGGAGTCACGACCAGGACCTTCTGTGGGACTCCAGATTATATCGCCCCAGAGATAATCGCTTATC AGCCGTATGGAAAATCTGTGGACTGGTGGGCCTATGGCGTCCTGTTGTATGAAATGCTTGCCGGGCAGCCTCCATTTGATGGTGAAGATG AAGACGAGCTATTTCAGTCTATCATGGAGCACAACGTTTCCTATCCAAAATCCTTGTCCAAGGAGGCTGTTTCTGTCTGCAAAGGACTGA TGACCAAACACCCAGCCAAGCGGCTGGGCTGTGGGCCTGAGGGGGAGAGGGACGTGAGAGAGCATGCCTTCTTCCGGAGGATCGACTGGG AAAAACTGGAGAACAGGGAGATCCAGCCACCATTCAAGCCCAAAGTGTGTGGCAAAGGAGCAGAGAACTTTGACAAGTTCTTCACACGAG GACAGCCCGTCTTAACACCACCTGATCAGCTGGTTATTGCTAACATAGACCAGTCTGATTTTGAAGGGTTCTCGTATGTCAACCCCCAGT TTGTGCACCCCATCTTACAGAGTGCAGTATGAAACTCACCAGCGAGAACAAACACCTCCCCAGCCCCCAGCCCTCCCCGCAGTGGGAAGT GAATCCTTAACCCTAAAATTTTAAGGCCACGGCCTTGTGTCTGATTCCATATGGAGGCCTGAAAATTGTAGGGTTATTAGTCCAAATGTG ATCAACTGTTCAGGGTCTCTCTCTTACAACCAAGAACATTATCTTAGTGGAAGATGGTACGTCATGCTCAGTGTCCAGTTTAATTCTGTA GAAGTTACGTCTGGCTCTAGGTTAACCCTTCCTAGAAAGCAAGCAGACTGTTGCCCCATTTTGGGTACAATTTGATATACTTTCCATACC CTCCATCTGTGGATTTTTCAGCATTGGAATCCCCCAACCAGAGATGTTAAAGTGAGCCTGTCCCAGGAAACATCTCCACCCAAGACGTCT TTGGAATCCAAGAACAGGAAGCCAAGAGAGTGAGCAGGGAGGGATTGGGGGTGGGGGAGGCCTCAAAATACCGACTGCGTCCATTCTCTG CCTCCATGGAAACAGCCCCTAGAATCTGAAAGGCCGGGATAAACCTAATCACTGTTCCCAAACATTGACAAATCCTAACCCAACCATGGT CCAGCAGTTACCAGTTTAAACAAAAAAACCTCAGATGAGTGTTGGGTGAATCTGTCATCTGGTACCCTCCTTGGTTGATAACTGTCTTGA TACTTTTCATTCTTTGTAAGAGGCCAAATCGTCTAAGGACGTTGCTGAACAAGCGTGTGAAATCATTTCAGATCAAGGATAAGCCAGTGT GTACATATGTTCATTTTAATCTCTGGGAGATTATTTTTCCATCCAGGGTGCCATCAGTAATCATGCCACTACTCACCAGTGTTGTTCACC AACACCCACCCCCACACACACCAACATTTTGCTGCCTACCTTGTTATCCTTCTCAAGAAGCTGAAGTGTACGCCCTCTCCCCTTTTGTGC TTATTTATTTAATAGGCTGCAGTGTCGCTTATGAAAGTACGATGTACAGTAACTTAATGGAAGTGCTGACTCTAGCATCAGCCTCTACCG ATTGATTTTCCTCCCTTCTCTAGCCCTGGATGTCCACTTAGGGATAAAAAGAATATGGTTTTGGTTCCCATTTCTAGTTCACGTTGAATG ACAGGCCTGGAGCTGTAGAATCAGGAAACCCGGATGCCTAACAGCTCAAAGATGTTTTGTTAATAGAAGGATTTTAATACGTTTTGCAAA TGCATCATGCAATGAATTTTGCATGTTTATAATAAACCTTAATAACAAGTGAATCTATATTATTGATATAATCGTATCAAGTATAAAGAG AGTATTATAATAATTTTATAAGACACAATTGTGCTCTATTTGTGCAGGTTCTTGTTTCTAATCCTCTTTTCTAATTAAGTTTTAGCTGAA TCCCTTGCTTCTGTGCTTTCCCTCCCTGCACATGGGCACTGTATCAGATAGATTACTTTTTAAATGTAGATAAAATTTCAAAAATGAATG GCTAGTTTACGTGATAGATTAGGCTCTTACTACATATGTGTGTGTATATATATGTATTTGATTCTACCTGCAAACAAATTTTTATTGGTG AGGACTATTTTTGAGCTGACACTCCCTCTTAGTTTCTTCATGTCACCTTTCGTCCTGGTTCCTCCGCCACTCTTCCTCTTGGGGACAACA GGAAGTGTCTGATTCCAGTCTGCCTAGTACGTTGGTACACACGTGGCATTGCCGCAGCACCTGGGCTGACCTTTGTGTGTGCGTGTGTGT GTGTTTCCTTCTTCCCTTCAGCCTGTGACTGTTGCTGACTCCAGGGGTGGGAGGGATGGGGAGACTCCCCTCTTGCTGTGTGTACTGGAC ACGCAGGAAGCATGCTGTCTTGCTGCCTCTGCAACGACCTGTCGTTTGCTCCAGCATGCACAAACTTCGTGAGACCAACACAGCCGTGCC CTGCAGGCACCAGCACGTGCTTTTCAGAGGCTGCGGACTTTCTTCCAGCCATTGTGGCATTGGCCTTTCCAGTCTTGGGAGGAGCGCGCT GCTTTGGTGAGACACCCCCATGCAAGGTCCTCAGAGTAGCCGGGTTCTACCACAAACAGAAACAGAATGAAAGTAGCTGTCAGTCCTTGT AGAGAGCCGCTCTGTTTCCTCCCAGAAGCATCTCCCAGCTAAGCTCGCATTATTTTTCTCCTCTGGCTGTTTGCCTGAAGTTCACAGAAC ACACAACCATGAAAGGCTTTTTGAGGTGAGAGGCCCAGGTGGTCCTGGCAACCCTGAGTAGAAGGAGAGACGGGGTAGGGAACGGGCCCG GCCAGAAAAGAACCATTTCTTCTGCCATCTTTTATGCACCATAGACATCGAGACTCCAGGGGGTCCTGGCTCCCCTGTCCCTGCAGCCCT GCAGGTCAGTGCATGATCTGGGTTCGTGTCCTGACCAGGTGCTCCTCCTTTGATCCGAGGGGAAAGGGACTGGTTTATAGAAAGAGCCTA GGAGACAAAAGGGCCAGTCCCCCTGCCCAGAATGGAGCAGCAGCAGGACAGACCCCCACGAGGCCCCCCAGAGAGGAGGAAGATCCCACG GAGGAACACATGAGGTTAGGGACCCTTGTTCAGCACCCCAAACAGCCTGCCTGTTTAAAGCAGGCAGCAGGCTTAGGCCTTCCCTGCAAC CCCAACACCCACAAGTTTGTTTCTCTAGGAAACACATTCACTGTCTCAGCTGGCTGTTACTCTCTCAGACCATATGGCAAAGTTTTCCAA GAAAATGCCCCGACAGGGGTGCCCAGCACACTGCCTGAGGGACAACAGACATCAGAACAAACCCCCAGAGAGAAACAGTCAAAATCAGGG CCCGGTGCAGTGTTGTCATGTGGAACCTGCTTTATCCATTGCTGAGTGTTGAATGTGGGTAATGGTTAGGGCTTTCCAGATCTCAGCAGC CAAAGACAGTTATTGTTGGAAGACTGTCATGTAGATAACCATGAGCAATGGCTCGCCTCAGAATCAGTTCATAAAATTCTATGGTACTGG CCCCTTCGTGGGTATTGTGTGAAATGAGATGGTGGCGAGGGGTGCGCTGTGGAACTGCCGCAGCCACGCAGGAGGTCCCTGGGGGATGCT TTGGGAAGTCCTTGCCCCTGAGCACTGCCTGATTGCCAGGGCCTGTGGAGGTCTAGGCCGCCTGGCAGAATCTAGCACCGTCCGAATCCC CGCAGGACCCATGGAGCTATGACCACACCAGGCCATTCAAATGGCTCTGCATTATCTTCCCTTGGAAGGTGGCCACTCCTCGGTGGCAGG GCCTTTCCCTGAGGCTGCAGGCCGTGGGCTGGCAGCCCGTCTCTTGGCATTTCAATTGAAGGTCACCAGGTGCTGGGTTTGAAAGGAAGT CACTGGAGTGCTGCCAGGGGCCGCCCTCCAAGGTTAATGAGAGGCCCACATCCAGGCAAGAACTAATTCAAAAGGCAGATCAGAAACCAC AGGAGTCAAAATTATTGCTCCGGCAGTGCTTCCCTTCCTTTCATCCACTGGCCTCGTGTGGTCCATGCAGGGCCACTGTCTGCCCTTTCT GATGCCACGTATTAGGCTTTCTTACTCAGAATTTTGATAGAAAACCATGGGGCCAAGAGCTCTGGAAGCCTGGCCGGAAAGACCAAGGTT CATGCAGCCCAACAAATGATTGTTGAGCACCTCTCGGAGCCAAAGTCCTTAGGCGAGTGTGGTGACTTCCTGGAAGGAGGATGCAGACTT CCAGAGAGCCCCCCCAACGGACGTGCTGAGAAGGGAGAGGGAGGCGGGGGCTGTAGTCAGGAAGGAGCCAGAGAAGAACAGGGTTTGGGT GCATCCAGAAATATGCCTGCAGTAGGAGGGAGAGGAAGGGGTGCCACCGTCAACGGCTTCCCATCGGAGGTGGTTGGTGCAGATGGAAGT TTCTGTCTGCTGGCCCTCAAGAGAGTGTTTTGCCAGGGACACAGTCTGTTCCTCCTCAGAAAACACCCCCCAAATGCTAACAACATCCCC ACCAGCTGCTAGAAGCCCCTTTCCCCTCCCCACCTTGAAGTAGCTCATAGTTCTCTGGGCAGAGCCAGACCATCCAGTGTACCCCAGAGG CCAGTAGGTTCCTGCCCATTTTCCTCTCTGGCTTCCTGCCAAGAATTATGGCAGCTGAGGATGAATGGAGAAGTAAAAACAACTAACACC GCACAACTAACAACTAACACCGCAGTTCCCACCTGGGTTCCACTTAGCAGGAGACATTTCGGAGGGTTTTTTTTGTTTTTGTTCCTGTTT TTTTTTTTTTTGCTGGAATTTGTTTTCTCAGTACTGAAAAGAGAAAAAGTGACAATCTTGTATTTTTAAAAGCCTCGGAAAGGTGATACC ATCTGACAGTCATTTTCTCACGTTGGTCTTCTAAAGTCACCTATTTCTTGTGTGTGCACATCACACCATTTCCTGTTTCTTTATAACCCG ACAAGGGTAGGAGTGCCTGTTTCCCCTGCTGGGCACACCAGACAATCGTAATCACAAAACAGACACTGAGCCAGGGGCCCAAAGGGTGTG ATCATGAGAGTTACCGGGACAGCAGTAGGCATGACAGTCACCAGGAAGGACAAGGGTGCTCTGTTGTTAGTGGCCACACACCAATTTGAC AAGGAGTGTTGCGAAATTTTTATTTATTTATTTATTTATTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCGGTGGTACAA TCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGACTACAGGTGCGTGCCACC ACACCCAGCTAAATTTTGTGTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTTGAACCCCTGACCTCATGATCTGCCT GCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAAAATATTTTTTTAAAGTCATTTTCCTTAAGCTGCTT GGGCTACATGTGAAATACACTGGACGGTCAACATTCCTGTCTCCTCCCATTTGGGCTGATGCAGCAGATCCAGGGAATGTTACCTGTTTC TGCTGCTAGAAGATCCAGGAAATTGGGAAGGTTACCTGACGCACACATGGATGAAGGCCATCATCTAGAAATGGGGTCAACCACAATTGT GTTAATTCCGTAGTGTCAGGGATTCTTCGGGAAGGTCAACAGTATGAAGGATTCTGACCCCTGTGCCTCCCATTTATGTGATCAGGTGAC AGTTAATAACCGTGGAGGTCACACTCAGCCATCCAACAGCCTTACAGTGACCCTACACAAAAGCCCCCAAATTCCAAAGACTTTTTCTTA ACCTAAAGGAAGAAATTATTTGTTAATTCCAGTAGAGCAACTGAATATACTGGGCTATTTGTACTTTTTTATAGAGAACTTTAATAATAA TTCTTTAAAAATGAGTTTTTAGAACAAAGCAACTGACGATTTCCTAAGATTCCAATGCCCTGGAGCTTGTAGGAGGACTTAGCCTGGGTC AGCTGGAGCACCCCCGACCTGATCTCCCACTGCCAGATTTTCCCATGCTCCTAGGGTATGGAGTCCACGTGGGAATGACTGCAAGTTCAG GTGGAACTTGGCCGACTGATGCTCTGCGAGTTTTTAATAGACACTGGGGACAACTGCTTAAGGTTTAGAAACTTCCAAACCACAGGAAAG ACATTTTTAGTGTCCCCCATCCAGAGGCAGCCCTGGAATAGGATTCCCAGGGGTTTCTGGGACCCCTTTCCTTGCTCCGTGAGGCTCTGT GGCCATCTTTTGGCAGGAGGAGGATGCTTCCTTGGCTCTGTGCCCAGACCCGCCTGGTCCCCAGGTCTCTCACCTTGGGTGAAGATTCAG AGATGCCCTGTAAGGATTTTGCCCACTGGGCAACTCAGAAATACTTCGATCTCCCAAGATATAAGAGGCAGCAGCAAACGTGCCTATTGA CGTCTGTTTCATAGTTACCACTTACGCGAGTAGACAGAACTCGGCTTTTCAGAAAATAGGTGTCAAGTCCACTTTATAAGAACCTTTTTT TCTAAAATAAGATAAAAGGTGGCTTTGCATTTTCTGATTAAACGACTGTGTCTTTGTCACCTCTGCTTAACTTTAGGAGTATCCATTCCT GTGATTGTAGACTTTTGTTGATATTCTTCCTGGAAGAATATCATTCTTTTCTTGAAGGGTTGGTTTACTAGAATATTCAAAATCAATCAT GAAGGCAGTTACTATTTTGAGTCTAAAGGTTTTCTAAAAATTAACCTCACATCCCTTCTGTTAGGGTCTTTCAGAATATCTTTTATAAAC AGAAGCATTTGAAGTCATTGCTTTTGCTACATGATTTGTGTGTGTGAAGGACATACCACGTTTAAATCATTAATTGAAAAACATCATATA AGCCCCAACTTTGTTTGGAGGAAGAGACGGAGGTTGAGGTTTTTCCTTCTGTATAAGCACCTACTGACAAAATGTAGAGGCCATTCAACC GTCAAACACCATTTGGTTATATCGCAGAGGAGACGGATGTGTAAATTACTGCATTGCTTTTTTTTTCAGTTTGTATAACCTCTAATCTCC >In-frame_ENST00000435340_ENST00000413366_TCGA-C8-A135-01A_PEMT_chr17_17480234_-_PRKCA_chr17_64637473_length(amino acids)=622AA_start in transcript=53_stop in transcript=1921 MKRSGNPGAEADFCVMTRLLGYVDPLDPSFVAAVITITFNPLYWNVDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVH KQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFK LKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISP SEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTV DRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCG TPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERD -------------------------------------------------------------- >In-frame_ENST00000255389_ENST00000413366_TCGA-C8-A135-01A_PEMT_chr17_17480234_-_PRKCA_chr17_64637473_length(transcript)=8715nt_BP=278nt GGCTCTATAGGTCCGGTTCCGGGGGCGCGTGGCTGCAGCGGGGCCCGCGTGGTGCCTCCTGAGGCGGCCCCCGGATGAAGAGATCTGGGA ACCCGGGAGCCGAGGTAACGAACAGCTCGGTGGCAGGGCCTGACTGCTGCGGAGGCCTCGGCAATATTGATTTTAGACAGGCAGACTTCT GCGTTATGACCCGGCTGCTGGGCTACGTGGACCCCCTGGATCCCAGCTTTGTGGCTGCCGTCATCACCATCACCTTCAATCCGCTCTACT GGAATGTGGACCCCAGGAGCAAGCACAAGTTCAAAATCCACACTTACGGAAGCCCCACCTTCTGCGATCACTGTGGGTCACTGCTCTATG GACTTATCCATCAAGGGATGAAATGTGACACCTGCGATATGAACGTTCACAAGCAATGCGTCATCAATGTCCCCAGCCTCTGCGGAATGG ATCACACTGAGAAGAGGGGGCGGATTTACCTAAAGGCTGAGGTTGCTGATGAAAAGCTCCATGTCACAGTACGAGATGCAAAAAATCTAA TCCCTATGGATCCAAACGGGCTTTCAGATCCTTATGTGAAGCTGAAACTTATTCCTGATCCCAAGAATGAAAGCAAGCAAAAAACCAAAA CCATCCGCTCCACACTAAATCCGCAGTGGAATGAGTCCTTTACATTCAAATTGAAACCTTCAGACAAAGACCGACGACTGTCTGTAGAAA TCTGGGACTGGGATCGAACAACAAGGAATGACTTCATGGGATCCCTTTCCTTTGGAGTTTCGGAGCTGATGAAGATGCCGGCCAGTGGAT GGTACAAGTTGCTTAACCAAGAAGAAGGTGAGTACTACAACGTACCCATTCCGGAAGGGGACGAGGAAGGAAACATGGAACTCAGGCAGA AATTCGAGAAAGCCAAACTTGGCCCTGCTGGCAACAAAGTCATCAGTCCCTCTGAAGACAGGAAACAACCTTCCAACAACCTTGACCGAG TGAAACTCACGGACTTCAATTTCCTCATGGTGTTGGGAAAGGGGAGTTTTGGAAAGGTGATGCTTGCCGACAGGAAGGGCACAGAAGAAC TGTATGCAATCAAAATCCTGAAGAAGGATGTGGTGATTCAGGATGATGACGTGGAGTGCACCATGGTAGAAAAGCGAGTCTTGGCCCTGC TTGACAAACCCCCGTTCTTGACGCAGCTGCACTCCTGCTTCCAGACAGTGGATCGGCTGTACTTCGTCATGGAATATGTCAACGGTGGGG ACCTCATGTACCACATTCAGCAAGTAGGAAAATTTAAGGAACCACAAGCAGTATTCTATGCGGCAGAGATTTCCATCGGATTGTTCTTTC TTCATAAAAGAGGAATCATTTATAGGGATCTGAAGTTAGATAACGTCATGTTGGATTCAGAAGGACATATCAAAATTGCTGACTTTGGGA TGTGCAAGGAACACATGATGGATGGAGTCACGACCAGGACCTTCTGTGGGACTCCAGATTATATCGCCCCAGAGATAATCGCTTATCAGC CGTATGGAAAATCTGTGGACTGGTGGGCCTATGGCGTCCTGTTGTATGAAATGCTTGCCGGGCAGCCTCCATTTGATGGTGAAGATGAAG ACGAGCTATTTCAGTCTATCATGGAGCACAACGTTTCCTATCCAAAATCCTTGTCCAAGGAGGCTGTTTCTGTCTGCAAAGGACTGATGA CCAAACACCCAGCCAAGCGGCTGGGCTGTGGGCCTGAGGGGGAGAGGGACGTGAGAGAGCATGCCTTCTTCCGGAGGATCGACTGGGAAA AACTGGAGAACAGGGAGATCCAGCCACCATTCAAGCCCAAAGTGTGTGGCAAAGGAGCAGAGAACTTTGACAAGTTCTTCACACGAGGAC AGCCCGTCTTAACACCACCTGATCAGCTGGTTATTGCTAACATAGACCAGTCTGATTTTGAAGGGTTCTCGTATGTCAACCCCCAGTTTG TGCACCCCATCTTACAGAGTGCAGTATGAAACTCACCAGCGAGAACAAACACCTCCCCAGCCCCCAGCCCTCCCCGCAGTGGGAAGTGAA TCCTTAACCCTAAAATTTTAAGGCCACGGCCTTGTGTCTGATTCCATATGGAGGCCTGAAAATTGTAGGGTTATTAGTCCAAATGTGATC AACTGTTCAGGGTCTCTCTCTTACAACCAAGAACATTATCTTAGTGGAAGATGGTACGTCATGCTCAGTGTCCAGTTTAATTCTGTAGAA GTTACGTCTGGCTCTAGGTTAACCCTTCCTAGAAAGCAAGCAGACTGTTGCCCCATTTTGGGTACAATTTGATATACTTTCCATACCCTC CATCTGTGGATTTTTCAGCATTGGAATCCCCCAACCAGAGATGTTAAAGTGAGCCTGTCCCAGGAAACATCTCCACCCAAGACGTCTTTG GAATCCAAGAACAGGAAGCCAAGAGAGTGAGCAGGGAGGGATTGGGGGTGGGGGAGGCCTCAAAATACCGACTGCGTCCATTCTCTGCCT CCATGGAAACAGCCCCTAGAATCTGAAAGGCCGGGATAAACCTAATCACTGTTCCCAAACATTGACAAATCCTAACCCAACCATGGTCCA GCAGTTACCAGTTTAAACAAAAAAACCTCAGATGAGTGTTGGGTGAATCTGTCATCTGGTACCCTCCTTGGTTGATAACTGTCTTGATAC TTTTCATTCTTTGTAAGAGGCCAAATCGTCTAAGGACGTTGCTGAACAAGCGTGTGAAATCATTTCAGATCAAGGATAAGCCAGTGTGTA CATATGTTCATTTTAATCTCTGGGAGATTATTTTTCCATCCAGGGTGCCATCAGTAATCATGCCACTACTCACCAGTGTTGTTCACCAAC ACCCACCCCCACACACACCAACATTTTGCTGCCTACCTTGTTATCCTTCTCAAGAAGCTGAAGTGTACGCCCTCTCCCCTTTTGTGCTTA TTTATTTAATAGGCTGCAGTGTCGCTTATGAAAGTACGATGTACAGTAACTTAATGGAAGTGCTGACTCTAGCATCAGCCTCTACCGATT GATTTTCCTCCCTTCTCTAGCCCTGGATGTCCACTTAGGGATAAAAAGAATATGGTTTTGGTTCCCATTTCTAGTTCACGTTGAATGACA GGCCTGGAGCTGTAGAATCAGGAAACCCGGATGCCTAACAGCTCAAAGATGTTTTGTTAATAGAAGGATTTTAATACGTTTTGCAAATGC ATCATGCAATGAATTTTGCATGTTTATAATAAACCTTAATAACAAGTGAATCTATATTATTGATATAATCGTATCAAGTATAAAGAGAGT ATTATAATAATTTTATAAGACACAATTGTGCTCTATTTGTGCAGGTTCTTGTTTCTAATCCTCTTTTCTAATTAAGTTTTAGCTGAATCC CTTGCTTCTGTGCTTTCCCTCCCTGCACATGGGCACTGTATCAGATAGATTACTTTTTAAATGTAGATAAAATTTCAAAAATGAATGGCT AGTTTACGTGATAGATTAGGCTCTTACTACATATGTGTGTGTATATATATGTATTTGATTCTACCTGCAAACAAATTTTTATTGGTGAGG ACTATTTTTGAGCTGACACTCCCTCTTAGTTTCTTCATGTCACCTTTCGTCCTGGTTCCTCCGCCACTCTTCCTCTTGGGGACAACAGGA AGTGTCTGATTCCAGTCTGCCTAGTACGTTGGTACACACGTGGCATTGCCGCAGCACCTGGGCTGACCTTTGTGTGTGCGTGTGTGTGTG TTTCCTTCTTCCCTTCAGCCTGTGACTGTTGCTGACTCCAGGGGTGGGAGGGATGGGGAGACTCCCCTCTTGCTGTGTGTACTGGACACG CAGGAAGCATGCTGTCTTGCTGCCTCTGCAACGACCTGTCGTTTGCTCCAGCATGCACAAACTTCGTGAGACCAACACAGCCGTGCCCTG CAGGCACCAGCACGTGCTTTTCAGAGGCTGCGGACTTTCTTCCAGCCATTGTGGCATTGGCCTTTCCAGTCTTGGGAGGAGCGCGCTGCT TTGGTGAGACACCCCCATGCAAGGTCCTCAGAGTAGCCGGGTTCTACCACAAACAGAAACAGAATGAAAGTAGCTGTCAGTCCTTGTAGA GAGCCGCTCTGTTTCCTCCCAGAAGCATCTCCCAGCTAAGCTCGCATTATTTTTCTCCTCTGGCTGTTTGCCTGAAGTTCACAGAACACA CAACCATGAAAGGCTTTTTGAGGTGAGAGGCCCAGGTGGTCCTGGCAACCCTGAGTAGAAGGAGAGACGGGGTAGGGAACGGGCCCGGCC AGAAAAGAACCATTTCTTCTGCCATCTTTTATGCACCATAGACATCGAGACTCCAGGGGGTCCTGGCTCCCCTGTCCCTGCAGCCCTGCA GGTCAGTGCATGATCTGGGTTCGTGTCCTGACCAGGTGCTCCTCCTTTGATCCGAGGGGAAAGGGACTGGTTTATAGAAAGAGCCTAGGA GACAAAAGGGCCAGTCCCCCTGCCCAGAATGGAGCAGCAGCAGGACAGACCCCCACGAGGCCCCCCAGAGAGGAGGAAGATCCCACGGAG GAACACATGAGGTTAGGGACCCTTGTTCAGCACCCCAAACAGCCTGCCTGTTTAAAGCAGGCAGCAGGCTTAGGCCTTCCCTGCAACCCC AACACCCACAAGTTTGTTTCTCTAGGAAACACATTCACTGTCTCAGCTGGCTGTTACTCTCTCAGACCATATGGCAAAGTTTTCCAAGAA AATGCCCCGACAGGGGTGCCCAGCACACTGCCTGAGGGACAACAGACATCAGAACAAACCCCCAGAGAGAAACAGTCAAAATCAGGGCCC GGTGCAGTGTTGTCATGTGGAACCTGCTTTATCCATTGCTGAGTGTTGAATGTGGGTAATGGTTAGGGCTTTCCAGATCTCAGCAGCCAA AGACAGTTATTGTTGGAAGACTGTCATGTAGATAACCATGAGCAATGGCTCGCCTCAGAATCAGTTCATAAAATTCTATGGTACTGGCCC CTTCGTGGGTATTGTGTGAAATGAGATGGTGGCGAGGGGTGCGCTGTGGAACTGCCGCAGCCACGCAGGAGGTCCCTGGGGGATGCTTTG GGAAGTCCTTGCCCCTGAGCACTGCCTGATTGCCAGGGCCTGTGGAGGTCTAGGCCGCCTGGCAGAATCTAGCACCGTCCGAATCCCCGC AGGACCCATGGAGCTATGACCACACCAGGCCATTCAAATGGCTCTGCATTATCTTCCCTTGGAAGGTGGCCACTCCTCGGTGGCAGGGCC TTTCCCTGAGGCTGCAGGCCGTGGGCTGGCAGCCCGTCTCTTGGCATTTCAATTGAAGGTCACCAGGTGCTGGGTTTGAAAGGAAGTCAC TGGAGTGCTGCCAGGGGCCGCCCTCCAAGGTTAATGAGAGGCCCACATCCAGGCAAGAACTAATTCAAAAGGCAGATCAGAAACCACAGG AGTCAAAATTATTGCTCCGGCAGTGCTTCCCTTCCTTTCATCCACTGGCCTCGTGTGGTCCATGCAGGGCCACTGTCTGCCCTTTCTGAT GCCACGTATTAGGCTTTCTTACTCAGAATTTTGATAGAAAACCATGGGGCCAAGAGCTCTGGAAGCCTGGCCGGAAAGACCAAGGTTCAT GCAGCCCAACAAATGATTGTTGAGCACCTCTCGGAGCCAAAGTCCTTAGGCGAGTGTGGTGACTTCCTGGAAGGAGGATGCAGACTTCCA GAGAGCCCCCCCAACGGACGTGCTGAGAAGGGAGAGGGAGGCGGGGGCTGTAGTCAGGAAGGAGCCAGAGAAGAACAGGGTTTGGGTGCA TCCAGAAATATGCCTGCAGTAGGAGGGAGAGGAAGGGGTGCCACCGTCAACGGCTTCCCATCGGAGGTGGTTGGTGCAGATGGAAGTTTC TGTCTGCTGGCCCTCAAGAGAGTGTTTTGCCAGGGACACAGTCTGTTCCTCCTCAGAAAACACCCCCCAAATGCTAACAACATCCCCACC AGCTGCTAGAAGCCCCTTTCCCCTCCCCACCTTGAAGTAGCTCATAGTTCTCTGGGCAGAGCCAGACCATCCAGTGTACCCCAGAGGCCA GTAGGTTCCTGCCCATTTTCCTCTCTGGCTTCCTGCCAAGAATTATGGCAGCTGAGGATGAATGGAGAAGTAAAAACAACTAACACCGCA CAACTAACAACTAACACCGCAGTTCCCACCTGGGTTCCACTTAGCAGGAGACATTTCGGAGGGTTTTTTTTGTTTTTGTTCCTGTTTTTT TTTTTTTTGCTGGAATTTGTTTTCTCAGTACTGAAAAGAGAAAAAGTGACAATCTTGTATTTTTAAAAGCCTCGGAAAGGTGATACCATC TGACAGTCATTTTCTCACGTTGGTCTTCTAAAGTCACCTATTTCTTGTGTGTGCACATCACACCATTTCCTGTTTCTTTATAACCCGACA AGGGTAGGAGTGCCTGTTTCCCCTGCTGGGCACACCAGACAATCGTAATCACAAAACAGACACTGAGCCAGGGGCCCAAAGGGTGTGATC ATGAGAGTTACCGGGACAGCAGTAGGCATGACAGTCACCAGGAAGGACAAGGGTGCTCTGTTGTTAGTGGCCACACACCAATTTGACAAG GAGTGTTGCGAAATTTTTATTTATTTATTTATTTATTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCGGTGGTACAATCT CGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGACTACAGGTGCGTGCCACCACA CCCAGCTAAATTTTGTGTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTTGAACCCCTGACCTCATGATCTGCCTGCC TCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAAAATATTTTTTTAAAGTCATTTTCCTTAAGCTGCTTGGG CTACATGTGAAATACACTGGACGGTCAACATTCCTGTCTCCTCCCATTTGGGCTGATGCAGCAGATCCAGGGAATGTTACCTGTTTCTGC TGCTAGAAGATCCAGGAAATTGGGAAGGTTACCTGACGCACACATGGATGAAGGCCATCATCTAGAAATGGGGTCAACCACAATTGTGTT AATTCCGTAGTGTCAGGGATTCTTCGGGAAGGTCAACAGTATGAAGGATTCTGACCCCTGTGCCTCCCATTTATGTGATCAGGTGACAGT TAATAACCGTGGAGGTCACACTCAGCCATCCAACAGCCTTACAGTGACCCTACACAAAAGCCCCCAAATTCCAAAGACTTTTTCTTAACC TAAAGGAAGAAATTATTTGTTAATTCCAGTAGAGCAACTGAATATACTGGGCTATTTGTACTTTTTTATAGAGAACTTTAATAATAATTC TTTAAAAATGAGTTTTTAGAACAAAGCAACTGACGATTTCCTAAGATTCCAATGCCCTGGAGCTTGTAGGAGGACTTAGCCTGGGTCAGC TGGAGCACCCCCGACCTGATCTCCCACTGCCAGATTTTCCCATGCTCCTAGGGTATGGAGTCCACGTGGGAATGACTGCAAGTTCAGGTG GAACTTGGCCGACTGATGCTCTGCGAGTTTTTAATAGACACTGGGGACAACTGCTTAAGGTTTAGAAACTTCCAAACCACAGGAAAGACA TTTTTAGTGTCCCCCATCCAGAGGCAGCCCTGGAATAGGATTCCCAGGGGTTTCTGGGACCCCTTTCCTTGCTCCGTGAGGCTCTGTGGC CATCTTTTGGCAGGAGGAGGATGCTTCCTTGGCTCTGTGCCCAGACCCGCCTGGTCCCCAGGTCTCTCACCTTGGGTGAAGATTCAGAGA TGCCCTGTAAGGATTTTGCCCACTGGGCAACTCAGAAATACTTCGATCTCCCAAGATATAAGAGGCAGCAGCAAACGTGCCTATTGACGT CTGTTTCATAGTTACCACTTACGCGAGTAGACAGAACTCGGCTTTTCAGAAAATAGGTGTCAAGTCCACTTTATAAGAACCTTTTTTTCT AAAATAAGATAAAAGGTGGCTTTGCATTTTCTGATTAAACGACTGTGTCTTTGTCACCTCTGCTTAACTTTAGGAGTATCCATTCCTGTG ATTGTAGACTTTTGTTGATATTCTTCCTGGAAGAATATCATTCTTTTCTTGAAGGGTTGGTTTACTAGAATATTCAAAATCAATCATGAA GGCAGTTACTATTTTGAGTCTAAAGGTTTTCTAAAAATTAACCTCACATCCCTTCTGTTAGGGTCTTTCAGAATATCTTTTATAAACAGA AGCATTTGAAGTCATTGCTTTTGCTACATGATTTGTGTGTGTGAAGGACATACCACGTTTAAATCATTAATTGAAAAACATCATATAAGC CCCAACTTTGTTTGGAGGAAGAGACGGAGGTTGAGGTTTTTCCTTCTGTATAAGCACCTACTGACAAAATGTAGAGGCCATTCAACCGTC AAACACCATTTGGTTATATCGCAGAGGAGACGGATGTGTAAATTACTGCATTGCTTTTTTTTTCAGTTTGTATAACCTCTAATCTCCGTT >In-frame_ENST00000255389_ENST00000413366_TCGA-C8-A135-01A_PEMT_chr17_17480234_-_PRKCA_chr17_64637473_length(amino acids)=644AA_start in transcript=74_stop in transcript=2008 MKRSGNPGAEVTNSSVAGPDCCGGLGNIDFRQADFCVMTRLLGYVDPLDPSFVAAVITITFNPLYWNVDPRSKHKFKIHTYGSPTFCDHC GSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNES KQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGN MELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEK RVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIK IADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSV CKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSY -------------------------------------------------------------- >In-frame_ENST00000395781_ENST00000413366_TCGA-C8-A135-01A_PEMT_chr17_17480234_-_PRKCA_chr17_64637473_length(transcript)=8723nt_BP=286nt ACTTACCCGGCTCTATAGGTCCGGTTCCGGGGGCGCGTGGCTGCAGCGGGGCCCGCGTGGTGCCTCCTGAGGCGGCCCCCGGATGAAGAG ATCTGGGAACCCGGGAGCCGAGGTAACGAACAGCTCGGTGGCAGGGCCTGACTGCTGCGGAGGCCTCGGCAATATTGATTTTAGACAGGC AGACTTCTGCGTTATGACCCGGCTGCTGGGCTACGTGGACCCCCTGGATCCCAGCTTTGTGGCTGCCGTCATCACCATCACCTTCAATCC GCTCTACTGGAATGTGGACCCCAGGAGCAAGCACAAGTTCAAAATCCACACTTACGGAAGCCCCACCTTCTGCGATCACTGTGGGTCACT GCTCTATGGACTTATCCATCAAGGGATGAAATGTGACACCTGCGATATGAACGTTCACAAGCAATGCGTCATCAATGTCCCCAGCCTCTG CGGAATGGATCACACTGAGAAGAGGGGGCGGATTTACCTAAAGGCTGAGGTTGCTGATGAAAAGCTCCATGTCACAGTACGAGATGCAAA AAATCTAATCCCTATGGATCCAAACGGGCTTTCAGATCCTTATGTGAAGCTGAAACTTATTCCTGATCCCAAGAATGAAAGCAAGCAAAA AACCAAAACCATCCGCTCCACACTAAATCCGCAGTGGAATGAGTCCTTTACATTCAAATTGAAACCTTCAGACAAAGACCGACGACTGTC TGTAGAAATCTGGGACTGGGATCGAACAACAAGGAATGACTTCATGGGATCCCTTTCCTTTGGAGTTTCGGAGCTGATGAAGATGCCGGC CAGTGGATGGTACAAGTTGCTTAACCAAGAAGAAGGTGAGTACTACAACGTACCCATTCCGGAAGGGGACGAGGAAGGAAACATGGAACT CAGGCAGAAATTCGAGAAAGCCAAACTTGGCCCTGCTGGCAACAAAGTCATCAGTCCCTCTGAAGACAGGAAACAACCTTCCAACAACCT TGACCGAGTGAAACTCACGGACTTCAATTTCCTCATGGTGTTGGGAAAGGGGAGTTTTGGAAAGGTGATGCTTGCCGACAGGAAGGGCAC AGAAGAACTGTATGCAATCAAAATCCTGAAGAAGGATGTGGTGATTCAGGATGATGACGTGGAGTGCACCATGGTAGAAAAGCGAGTCTT GGCCCTGCTTGACAAACCCCCGTTCTTGACGCAGCTGCACTCCTGCTTCCAGACAGTGGATCGGCTGTACTTCGTCATGGAATATGTCAA CGGTGGGGACCTCATGTACCACATTCAGCAAGTAGGAAAATTTAAGGAACCACAAGCAGTATTCTATGCGGCAGAGATTTCCATCGGATT GTTCTTTCTTCATAAAAGAGGAATCATTTATAGGGATCTGAAGTTAGATAACGTCATGTTGGATTCAGAAGGACATATCAAAATTGCTGA CTTTGGGATGTGCAAGGAACACATGATGGATGGAGTCACGACCAGGACCTTCTGTGGGACTCCAGATTATATCGCCCCAGAGATAATCGC TTATCAGCCGTATGGAAAATCTGTGGACTGGTGGGCCTATGGCGTCCTGTTGTATGAAATGCTTGCCGGGCAGCCTCCATTTGATGGTGA AGATGAAGACGAGCTATTTCAGTCTATCATGGAGCACAACGTTTCCTATCCAAAATCCTTGTCCAAGGAGGCTGTTTCTGTCTGCAAAGG ACTGATGACCAAACACCCAGCCAAGCGGCTGGGCTGTGGGCCTGAGGGGGAGAGGGACGTGAGAGAGCATGCCTTCTTCCGGAGGATCGA CTGGGAAAAACTGGAGAACAGGGAGATCCAGCCACCATTCAAGCCCAAAGTGTGTGGCAAAGGAGCAGAGAACTTTGACAAGTTCTTCAC ACGAGGACAGCCCGTCTTAACACCACCTGATCAGCTGGTTATTGCTAACATAGACCAGTCTGATTTTGAAGGGTTCTCGTATGTCAACCC CCAGTTTGTGCACCCCATCTTACAGAGTGCAGTATGAAACTCACCAGCGAGAACAAACACCTCCCCAGCCCCCAGCCCTCCCCGCAGTGG GAAGTGAATCCTTAACCCTAAAATTTTAAGGCCACGGCCTTGTGTCTGATTCCATATGGAGGCCTGAAAATTGTAGGGTTATTAGTCCAA ATGTGATCAACTGTTCAGGGTCTCTCTCTTACAACCAAGAACATTATCTTAGTGGAAGATGGTACGTCATGCTCAGTGTCCAGTTTAATT CTGTAGAAGTTACGTCTGGCTCTAGGTTAACCCTTCCTAGAAAGCAAGCAGACTGTTGCCCCATTTTGGGTACAATTTGATATACTTTCC ATACCCTCCATCTGTGGATTTTTCAGCATTGGAATCCCCCAACCAGAGATGTTAAAGTGAGCCTGTCCCAGGAAACATCTCCACCCAAGA CGTCTTTGGAATCCAAGAACAGGAAGCCAAGAGAGTGAGCAGGGAGGGATTGGGGGTGGGGGAGGCCTCAAAATACCGACTGCGTCCATT CTCTGCCTCCATGGAAACAGCCCCTAGAATCTGAAAGGCCGGGATAAACCTAATCACTGTTCCCAAACATTGACAAATCCTAACCCAACC ATGGTCCAGCAGTTACCAGTTTAAACAAAAAAACCTCAGATGAGTGTTGGGTGAATCTGTCATCTGGTACCCTCCTTGGTTGATAACTGT CTTGATACTTTTCATTCTTTGTAAGAGGCCAAATCGTCTAAGGACGTTGCTGAACAAGCGTGTGAAATCATTTCAGATCAAGGATAAGCC AGTGTGTACATATGTTCATTTTAATCTCTGGGAGATTATTTTTCCATCCAGGGTGCCATCAGTAATCATGCCACTACTCACCAGTGTTGT TCACCAACACCCACCCCCACACACACCAACATTTTGCTGCCTACCTTGTTATCCTTCTCAAGAAGCTGAAGTGTACGCCCTCTCCCCTTT TGTGCTTATTTATTTAATAGGCTGCAGTGTCGCTTATGAAAGTACGATGTACAGTAACTTAATGGAAGTGCTGACTCTAGCATCAGCCTC TACCGATTGATTTTCCTCCCTTCTCTAGCCCTGGATGTCCACTTAGGGATAAAAAGAATATGGTTTTGGTTCCCATTTCTAGTTCACGTT GAATGACAGGCCTGGAGCTGTAGAATCAGGAAACCCGGATGCCTAACAGCTCAAAGATGTTTTGTTAATAGAAGGATTTTAATACGTTTT GCAAATGCATCATGCAATGAATTTTGCATGTTTATAATAAACCTTAATAACAAGTGAATCTATATTATTGATATAATCGTATCAAGTATA AAGAGAGTATTATAATAATTTTATAAGACACAATTGTGCTCTATTTGTGCAGGTTCTTGTTTCTAATCCTCTTTTCTAATTAAGTTTTAG CTGAATCCCTTGCTTCTGTGCTTTCCCTCCCTGCACATGGGCACTGTATCAGATAGATTACTTTTTAAATGTAGATAAAATTTCAAAAAT GAATGGCTAGTTTACGTGATAGATTAGGCTCTTACTACATATGTGTGTGTATATATATGTATTTGATTCTACCTGCAAACAAATTTTTAT TGGTGAGGACTATTTTTGAGCTGACACTCCCTCTTAGTTTCTTCATGTCACCTTTCGTCCTGGTTCCTCCGCCACTCTTCCTCTTGGGGA CAACAGGAAGTGTCTGATTCCAGTCTGCCTAGTACGTTGGTACACACGTGGCATTGCCGCAGCACCTGGGCTGACCTTTGTGTGTGCGTG TGTGTGTGTTTCCTTCTTCCCTTCAGCCTGTGACTGTTGCTGACTCCAGGGGTGGGAGGGATGGGGAGACTCCCCTCTTGCTGTGTGTAC TGGACACGCAGGAAGCATGCTGTCTTGCTGCCTCTGCAACGACCTGTCGTTTGCTCCAGCATGCACAAACTTCGTGAGACCAACACAGCC GTGCCCTGCAGGCACCAGCACGTGCTTTTCAGAGGCTGCGGACTTTCTTCCAGCCATTGTGGCATTGGCCTTTCCAGTCTTGGGAGGAGC GCGCTGCTTTGGTGAGACACCCCCATGCAAGGTCCTCAGAGTAGCCGGGTTCTACCACAAACAGAAACAGAATGAAAGTAGCTGTCAGTC CTTGTAGAGAGCCGCTCTGTTTCCTCCCAGAAGCATCTCCCAGCTAAGCTCGCATTATTTTTCTCCTCTGGCTGTTTGCCTGAAGTTCAC AGAACACACAACCATGAAAGGCTTTTTGAGGTGAGAGGCCCAGGTGGTCCTGGCAACCCTGAGTAGAAGGAGAGACGGGGTAGGGAACGG GCCCGGCCAGAAAAGAACCATTTCTTCTGCCATCTTTTATGCACCATAGACATCGAGACTCCAGGGGGTCCTGGCTCCCCTGTCCCTGCA GCCCTGCAGGTCAGTGCATGATCTGGGTTCGTGTCCTGACCAGGTGCTCCTCCTTTGATCCGAGGGGAAAGGGACTGGTTTATAGAAAGA GCCTAGGAGACAAAAGGGCCAGTCCCCCTGCCCAGAATGGAGCAGCAGCAGGACAGACCCCCACGAGGCCCCCCAGAGAGGAGGAAGATC CCACGGAGGAACACATGAGGTTAGGGACCCTTGTTCAGCACCCCAAACAGCCTGCCTGTTTAAAGCAGGCAGCAGGCTTAGGCCTTCCCT GCAACCCCAACACCCACAAGTTTGTTTCTCTAGGAAACACATTCACTGTCTCAGCTGGCTGTTACTCTCTCAGACCATATGGCAAAGTTT TCCAAGAAAATGCCCCGACAGGGGTGCCCAGCACACTGCCTGAGGGACAACAGACATCAGAACAAACCCCCAGAGAGAAACAGTCAAAAT CAGGGCCCGGTGCAGTGTTGTCATGTGGAACCTGCTTTATCCATTGCTGAGTGTTGAATGTGGGTAATGGTTAGGGCTTTCCAGATCTCA GCAGCCAAAGACAGTTATTGTTGGAAGACTGTCATGTAGATAACCATGAGCAATGGCTCGCCTCAGAATCAGTTCATAAAATTCTATGGT ACTGGCCCCTTCGTGGGTATTGTGTGAAATGAGATGGTGGCGAGGGGTGCGCTGTGGAACTGCCGCAGCCACGCAGGAGGTCCCTGGGGG ATGCTTTGGGAAGTCCTTGCCCCTGAGCACTGCCTGATTGCCAGGGCCTGTGGAGGTCTAGGCCGCCTGGCAGAATCTAGCACCGTCCGA ATCCCCGCAGGACCCATGGAGCTATGACCACACCAGGCCATTCAAATGGCTCTGCATTATCTTCCCTTGGAAGGTGGCCACTCCTCGGTG GCAGGGCCTTTCCCTGAGGCTGCAGGCCGTGGGCTGGCAGCCCGTCTCTTGGCATTTCAATTGAAGGTCACCAGGTGCTGGGTTTGAAAG GAAGTCACTGGAGTGCTGCCAGGGGCCGCCCTCCAAGGTTAATGAGAGGCCCACATCCAGGCAAGAACTAATTCAAAAGGCAGATCAGAA ACCACAGGAGTCAAAATTATTGCTCCGGCAGTGCTTCCCTTCCTTTCATCCACTGGCCTCGTGTGGTCCATGCAGGGCCACTGTCTGCCC TTTCTGATGCCACGTATTAGGCTTTCTTACTCAGAATTTTGATAGAAAACCATGGGGCCAAGAGCTCTGGAAGCCTGGCCGGAAAGACCA AGGTTCATGCAGCCCAACAAATGATTGTTGAGCACCTCTCGGAGCCAAAGTCCTTAGGCGAGTGTGGTGACTTCCTGGAAGGAGGATGCA GACTTCCAGAGAGCCCCCCCAACGGACGTGCTGAGAAGGGAGAGGGAGGCGGGGGCTGTAGTCAGGAAGGAGCCAGAGAAGAACAGGGTT TGGGTGCATCCAGAAATATGCCTGCAGTAGGAGGGAGAGGAAGGGGTGCCACCGTCAACGGCTTCCCATCGGAGGTGGTTGGTGCAGATG GAAGTTTCTGTCTGCTGGCCCTCAAGAGAGTGTTTTGCCAGGGACACAGTCTGTTCCTCCTCAGAAAACACCCCCCAAATGCTAACAACA TCCCCACCAGCTGCTAGAAGCCCCTTTCCCCTCCCCACCTTGAAGTAGCTCATAGTTCTCTGGGCAGAGCCAGACCATCCAGTGTACCCC AGAGGCCAGTAGGTTCCTGCCCATTTTCCTCTCTGGCTTCCTGCCAAGAATTATGGCAGCTGAGGATGAATGGAGAAGTAAAAACAACTA ACACCGCACAACTAACAACTAACACCGCAGTTCCCACCTGGGTTCCACTTAGCAGGAGACATTTCGGAGGGTTTTTTTTGTTTTTGTTCC TGTTTTTTTTTTTTTTGCTGGAATTTGTTTTCTCAGTACTGAAAAGAGAAAAAGTGACAATCTTGTATTTTTAAAAGCCTCGGAAAGGTG ATACCATCTGACAGTCATTTTCTCACGTTGGTCTTCTAAAGTCACCTATTTCTTGTGTGTGCACATCACACCATTTCCTGTTTCTTTATA ACCCGACAAGGGTAGGAGTGCCTGTTTCCCCTGCTGGGCACACCAGACAATCGTAATCACAAAACAGACACTGAGCCAGGGGCCCAAAGG GTGTGATCATGAGAGTTACCGGGACAGCAGTAGGCATGACAGTCACCAGGAAGGACAAGGGTGCTCTGTTGTTAGTGGCCACACACCAAT TTGACAAGGAGTGTTGCGAAATTTTTATTTATTTATTTATTTATTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCGGTGG TACAATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGACTACAGGTGCGTG CCACCACACCCAGCTAAATTTTGTGTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTTGAACCCCTGACCTCATGATC TGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAAAATATTTTTTTAAAGTCATTTTCCTTAAGC TGCTTGGGCTACATGTGAAATACACTGGACGGTCAACATTCCTGTCTCCTCCCATTTGGGCTGATGCAGCAGATCCAGGGAATGTTACCT GTTTCTGCTGCTAGAAGATCCAGGAAATTGGGAAGGTTACCTGACGCACACATGGATGAAGGCCATCATCTAGAAATGGGGTCAACCACA ATTGTGTTAATTCCGTAGTGTCAGGGATTCTTCGGGAAGGTCAACAGTATGAAGGATTCTGACCCCTGTGCCTCCCATTTATGTGATCAG GTGACAGTTAATAACCGTGGAGGTCACACTCAGCCATCCAACAGCCTTACAGTGACCCTACACAAAAGCCCCCAAATTCCAAAGACTTTT TCTTAACCTAAAGGAAGAAATTATTTGTTAATTCCAGTAGAGCAACTGAATATACTGGGCTATTTGTACTTTTTTATAGAGAACTTTAAT AATAATTCTTTAAAAATGAGTTTTTAGAACAAAGCAACTGACGATTTCCTAAGATTCCAATGCCCTGGAGCTTGTAGGAGGACTTAGCCT GGGTCAGCTGGAGCACCCCCGACCTGATCTCCCACTGCCAGATTTTCCCATGCTCCTAGGGTATGGAGTCCACGTGGGAATGACTGCAAG TTCAGGTGGAACTTGGCCGACTGATGCTCTGCGAGTTTTTAATAGACACTGGGGACAACTGCTTAAGGTTTAGAAACTTCCAAACCACAG GAAAGACATTTTTAGTGTCCCCCATCCAGAGGCAGCCCTGGAATAGGATTCCCAGGGGTTTCTGGGACCCCTTTCCTTGCTCCGTGAGGC TCTGTGGCCATCTTTTGGCAGGAGGAGGATGCTTCCTTGGCTCTGTGCCCAGACCCGCCTGGTCCCCAGGTCTCTCACCTTGGGTGAAGA TTCAGAGATGCCCTGTAAGGATTTTGCCCACTGGGCAACTCAGAAATACTTCGATCTCCCAAGATATAAGAGGCAGCAGCAAACGTGCCT ATTGACGTCTGTTTCATAGTTACCACTTACGCGAGTAGACAGAACTCGGCTTTTCAGAAAATAGGTGTCAAGTCCACTTTATAAGAACCT TTTTTTCTAAAATAAGATAAAAGGTGGCTTTGCATTTTCTGATTAAACGACTGTGTCTTTGTCACCTCTGCTTAACTTTAGGAGTATCCA TTCCTGTGATTGTAGACTTTTGTTGATATTCTTCCTGGAAGAATATCATTCTTTTCTTGAAGGGTTGGTTTACTAGAATATTCAAAATCA ATCATGAAGGCAGTTACTATTTTGAGTCTAAAGGTTTTCTAAAAATTAACCTCACATCCCTTCTGTTAGGGTCTTTCAGAATATCTTTTA TAAACAGAAGCATTTGAAGTCATTGCTTTTGCTACATGATTTGTGTGTGTGAAGGACATACCACGTTTAAATCATTAATTGAAAAACATC ATATAAGCCCCAACTTTGTTTGGAGGAAGAGACGGAGGTTGAGGTTTTTCCTTCTGTATAAGCACCTACTGACAAAATGTAGAGGCCATT CAACCGTCAAACACCATTTGGTTATATCGCAGAGGAGACGGATGTGTAAATTACTGCATTGCTTTTTTTTTCAGTTTGTATAACCTCTAA >In-frame_ENST00000395781_ENST00000413366_TCGA-C8-A135-01A_PEMT_chr17_17480234_-_PRKCA_chr17_64637473_length(amino acids)=644AA_start in transcript=82_stop in transcript=2016 MKRSGNPGAEVTNSSVAGPDCCGGLGNIDFRQADFCVMTRLLGYVDPLDPSFVAAVITITFNPLYWNVDPRSKHKFKIHTYGSPTFCDHC GSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNES KQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGN MELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEK RVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIK IADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSV CKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PEMT-PRKCA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PEMT-PRKCA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PEMT-PRKCA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PEMT | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | PEMT | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Hgene | PEMT | C0239946 | Fibrosis, Liver | 1 | CTD_human |
| Hgene | PEMT | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| Hgene | PEMT | C3241937 | Nonalcoholic Steatohepatitis | 1 | CTD_human |
| Tgene | PRKCA | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | PRKCA | C0002152 | Alloxan Diabetes | 1 | CTD_human |
| Tgene | PRKCA | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| Tgene | PRKCA | C0018800 | Cardiomegaly | 1 | CTD_human |
| Tgene | PRKCA | C0021841 | Intestinal Neoplasms | 1 | CTD_human |
| Tgene | PRKCA | C0032617 | Polyuria | 1 | CTD_human |
| Tgene | PRKCA | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Tgene | PRKCA | C0036337 | Schizoaffective Disorder | 1 | PSYGENET |
| Tgene | PRKCA | C0038433 | Streptozotocin Diabetes | 1 | CTD_human |
| Tgene | PRKCA | C0162283 | Nephrogenic Diabetes Insipidus | 1 | CTD_human |
| Tgene | PRKCA | C0264423 | Asthma, Occupational | 1 | CTD_human |
| Tgene | PRKCA | C0268443 | Acquired Nephrogenic Diabetes Insipidus | 1 | CTD_human |
| Tgene | PRKCA | C0346627 | Intestinal Cancer | 1 | CTD_human |
| Tgene | PRKCA | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Tgene | PRKCA | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| Tgene | PRKCA | C0677501 | Congenital Nephrogenic Diabetes Insipidus | 1 | CTD_human |
| Tgene | PRKCA | C1383860 | Cardiac Hypertrophy | 1 | CTD_human |
| Tgene | PRKCA | C1563705 | Nephrogenic Diabetes Insipidus, Type I | 1 | CTD_human |
| Tgene | PRKCA | C1563706 | Nephrogenic Diabetes Insipidus, Type II | 1 | CTD_human |
| Tgene | PRKCA | C3241937 | Nonalcoholic Steatohepatitis | 1 | CTD_human |
| Tgene | PRKCA | C3542500 | ADH-Resistant Diabetes Insipidus | 1 | CTD_human |
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