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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PER2-HDAC4 (FusionGDB2 ID:63896) |
Fusion Gene Summary for PER2-HDAC4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PER2-HDAC4 | Fusion gene ID: 63896 | Hgene | Tgene | Gene symbol | PER2 | HDAC4 | Gene ID | 8864 | 9759 |
| Gene name | period circadian regulator 2 | histone deacetylase 4 | |
| Synonyms | FASPS|FASPS1 | AHO3|BDMR|HA6116|HD4|HDAC-4|HDAC-A|HDACA | |
| Cytomap | 2q37.3 | 2q37.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | period circadian protein homolog 2circadian clock protein PERIOD 2hPER2period 2period circadian clock 2period circadian protein 2period homolog 2 | histone deacetylase 4histone deacetylase A | |
| Modification date | 20200322 | 20200329 | |
| UniProtAcc | . | P56524 | |
| Ensembl transtripts involved in fusion gene | ENST00000254658, ENST00000254657, ENST00000440245, ENST00000355768, | ENST00000345617, ENST00000543185, ENST00000541256, ENST00000553145, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 11 X 11 X 4=484 |
| # samples | 3 | 11 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/484*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PER2 [Title/Abstract] AND HDAC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | HDAC4(239583758)-PER2(239182157), # samples:1 PER2(239157703)-HDAC4(240037006), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | PER2-HDAC4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. PER2-HDAC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PER2-HDAC4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PER2-HDAC4 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HDAC4 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10869435|16236793 |
| Tgene | HDAC4 | GO:0006338 | chromatin remodeling | 18850004 |
| Tgene | HDAC4 | GO:0006476 | protein deacetylation | 27708256 |
| Tgene | HDAC4 | GO:0016575 | histone deacetylation | 10869435 |
| Tgene | HDAC4 | GO:0033235 | positive regulation of protein sumoylation | 17696781 |
| Tgene | HDAC4 | GO:0034983 | peptidyl-lysine deacetylation | 18614528 |
| Tgene | HDAC4 | GO:0045892 | negative regulation of transcription, DNA-templated | 10869435 |
| Tgene | HDAC4 | GO:0070932 | histone H3 deacetylation | 12590135 |
| Tgene | HDAC4 | GO:0070933 | histone H4 deacetylation | 12590135 |
| Fusion gene breakpoints across PER2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across HDAC4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-D3-A3MO-06A | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
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Fusion Gene ORF analysis for PER2-HDAC4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000254658 | ENST00000345617 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| 3UTR-3CDS | ENST00000254658 | ENST00000543185 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| 3UTR-3CDS | ENST00000254658 | ENST00000541256 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| 3UTR-intron | ENST00000254658 | ENST00000553145 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| Frame-shift | ENST00000254657 | ENST00000345617 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| Frame-shift | ENST00000254657 | ENST00000543185 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| Frame-shift | ENST00000254657 | ENST00000541256 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| 5CDS-intron | ENST00000254657 | ENST00000553145 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| intron-3CDS | ENST00000440245 | ENST00000345617 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| intron-3CDS | ENST00000440245 | ENST00000543185 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| intron-3CDS | ENST00000440245 | ENST00000541256 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| intron-intron | ENST00000440245 | ENST00000553145 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| intron-3CDS | ENST00000355768 | ENST00000345617 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| intron-3CDS | ENST00000355768 | ENST00000543185 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| intron-3CDS | ENST00000355768 | ENST00000541256 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| intron-intron | ENST00000355768 | ENST00000553145 | PER2 | chr2 | 239157703 | - | HDAC4 | chr2 | 240037006 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for PER2-HDAC4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PER2-HDAC4 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | HDAC4 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for PER2-HDAC4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for PER2-HDAC4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PER2-HDAC4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | HDAC4 | P56524 | DB14548 | Zinc sulfate, unspecified form | Cofactor | Small molecule | Approved|Experimental |
| Tgene | HDAC4 | P56524 | DB14548 | Zinc sulfate, unspecified form | Cofactor | Small molecule | Approved|Experimental |
| Tgene | HDAC4 | P56524 | DB01593 | Zinc | Cofactor | Small molecule | Approved|Investigational |
| Tgene | HDAC4 | P56524 | DB01593 | Zinc | Cofactor | Small molecule | Approved|Investigational |
| Tgene | HDAC4 | P56524 | DB06176 | Romidepsin | Inhibitor | Small molecule | Approved|Investigational |
| Tgene | HDAC4 | P56524 | DB06176 | Romidepsin | Inhibitor | Small molecule | Approved|Investigational |
| Tgene | HDAC4 | P56524 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Tgene | HDAC4 | P56524 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Tgene | HDAC4 | P56524 | DB14533 | Zinc chloride | Cofactor | Small molecule | Approved|Investigational |
| Tgene | HDAC4 | P56524 | DB14533 | Zinc chloride | Cofactor | Small molecule | Approved|Investigational |
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Related Diseases for PER2-HDAC4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PER2 | C0011570 | Mental Depression | 5 | PSYGENET |
| Hgene | PER2 | C0011581 | Depressive disorder | 5 | PSYGENET |
| Hgene | PER2 | C0005586 | Bipolar Disorder | 4 | PSYGENET |
| Hgene | PER2 | C0038587 | Substance Withdrawal Syndrome | 2 | CTD_human |
| Hgene | PER2 | C0086189 | Drug Withdrawal Symptoms | 2 | CTD_human |
| Hgene | PER2 | C0087169 | Withdrawal Symptoms | 2 | CTD_human |
| Hgene | PER2 | C0221074 | Depression, Postpartum | 2 | PSYGENET |
| Hgene | PER2 | C0600427 | Cocaine Dependence | 2 | PSYGENET |
| Hgene | PER2 | C0001969 | Alcoholic Intoxication | 1 | CTD_human |
| Hgene | PER2 | C0023473 | Myeloid Leukemia, Chronic | 1 | CTD_human |
| Hgene | PER2 | C0858355 | Addicted to cocaine | 1 | PSYGENET |
| Hgene | PER2 | C1858496 | Advanced Sleep-Phase Syndrome, Familial | 1 | CTD_human;ORPHANET |
| Hgene | PER2 | C3807327 | ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 1 | 1 | GENOMICS_ENGLAND;UNIPROT |
| Tgene | HDAC4 | C2931817 | Chromosome 2q37 deletion syndrome | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Tgene | HDAC4 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | HDAC4 | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| Tgene | HDAC4 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | HDAC4 | C0009171 | Cocaine Abuse | 1 | CTD_human |
| Tgene | HDAC4 | C0011570 | Mental Depression | 1 | PSYGENET |
| Tgene | HDAC4 | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Tgene | HDAC4 | C0020796 | Profound Mental Retardation | 1 | CTD_human |
| Tgene | HDAC4 | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human |
| Tgene | HDAC4 | C0162351 | Contact hypersensitivity | 1 | CTD_human |
| Tgene | HDAC4 | C0221357 | Brachydactyly | 1 | CTD_human |
| Tgene | HDAC4 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Tgene | HDAC4 | C0340543 | Familial primary pulmonary hypertension | 1 | CTD_human |
| Tgene | HDAC4 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | HDAC4 | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | HDAC4 | C0600427 | Cocaine Dependence | 1 | CTD_human |
| Tgene | HDAC4 | C0917816 | Mental deficiency | 1 | CTD_human |
| Tgene | HDAC4 | C1862102 | BRACHYDACTYLY, TYPE E1 | 1 | CTD_human |
| Tgene | HDAC4 | C1969342 | PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED | 1 | CTD_human |
| Tgene | HDAC4 | C1969343 | Pulmonary Hypertension, Primary, Fenfluramine-Associated | 1 | CTD_human |
| Tgene | HDAC4 | C3203102 | Idiopathic pulmonary arterial hypertension | 1 | CTD_human |
| Tgene | HDAC4 | C3714756 | Intellectual Disability | 1 | CTD_human |
| Tgene | HDAC4 | C3714844 | Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 1 | CTD_human |
| Tgene | HDAC4 | C4552070 | Pulmonary Hypertension, Primary, 1 | 1 | CTD_human |
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