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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PEX10-FAM210A (FusionGDB2 ID:63934)

Fusion Gene Summary for PEX10-FAM210A

check button Fusion gene summary
Fusion gene informationFusion gene name: PEX10-FAM210A
Fusion gene ID: 63934
HgeneTgene
Gene symbol

PEX10

FAM210A

Gene ID

5192

125228

Gene nameperoxisomal biogenesis factor 10family with sequence similarity 210 member A
SynonymsNALD|PBD6A|PBD6B|RNF69C18orf19|HsT2329
Cytomap

1p36.32

18p11.21

Type of geneprotein-codingprotein-coding
Descriptionperoxisome biogenesis factor 10RING finger protein 69peroxin 10peroxisome assembly protein 10protein FAM210Auncharacterized protein C18orf19
Modification date2020031320200313
UniProtAcc.

Q96ND0

Ensembl transtripts involved in fusion geneENST00000288774, ENST00000447513, 
ENST00000507596, ENST00000515760, 
ENST00000322247, ENST00000402563, 
ENST00000588475, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 3=27
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PEX10 [Title/Abstract] AND FAM210A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPEX10(2343830)-FAM210A(13666712), # samples:1
Anticipated loss of major functional domain due to fusion event.PEX10-FAM210A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PEX10-FAM210A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePEX10

GO:0007031

peroxisome organization

9700193

HgenePEX10

GO:0016558

protein import into peroxisome matrix

9683594


check buttonFusion gene breakpoints across PEX10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FAM210A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A4Z0-01APEX10chr1

2343830

-FAM210Achr18

13666712

-


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Fusion Gene ORF analysis for PEX10-FAM210A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000288774ENST00000322247PEX10chr1

2343830

-FAM210Achr18

13666712

-
Frame-shiftENST00000288774ENST00000402563PEX10chr1

2343830

-FAM210Achr18

13666712

-
5CDS-5UTRENST00000288774ENST00000588475PEX10chr1

2343830

-FAM210Achr18

13666712

-
In-frameENST00000447513ENST00000322247PEX10chr1

2343830

-FAM210Achr18

13666712

-
Frame-shiftENST00000447513ENST00000402563PEX10chr1

2343830

-FAM210Achr18

13666712

-
5CDS-5UTRENST00000447513ENST00000588475PEX10chr1

2343830

-FAM210Achr18

13666712

-
In-frameENST00000507596ENST00000322247PEX10chr1

2343830

-FAM210Achr18

13666712

-
Frame-shiftENST00000507596ENST00000402563PEX10chr1

2343830

-FAM210Achr18

13666712

-
5CDS-5UTRENST00000507596ENST00000588475PEX10chr1

2343830

-FAM210Achr18

13666712

-
intron-3CDSENST00000515760ENST00000322247PEX10chr1

2343830

-FAM210Achr18

13666712

-
intron-3CDSENST00000515760ENST00000402563PEX10chr1

2343830

-FAM210Achr18

13666712

-
intron-5UTRENST00000515760ENST00000588475PEX10chr1

2343830

-FAM210Achr18

13666712

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000288774PEX10chr12343830-ENST00000322247FAM210Achr1813666712-350714014421756104
ENST00000447513PEX10chr12343830-ENST00000322247FAM210Achr1813666712-354818114831797104
ENST00000507596PEX10chr12343830-ENST00000322247FAM210Achr1813666712-351715014521766104

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000288774ENST00000322247PEX10chr12343830-FAM210Achr1813666712-0.24722490.7527751
ENST00000447513ENST00000322247PEX10chr12343830-FAM210Achr1813666712-0.24711720.7528828
ENST00000507596ENST00000322247PEX10chr12343830-FAM210Achr1813666712-0.244318930.7556811

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Fusion Genomic Features for PEX10-FAM210A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PEX10-FAM210A


check button Go to

FGviewer for the breakpoints of chr1:2343830-chr18:13666712

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAM210A

Q96ND0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May play a role in the structure and strength of both muscle and bone. {ECO:0000250|UniProtKB:Q8BGY7}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAM210Achr1:2343830chr18:13666712ENST0000032224735229_271195.0273.0Coiled coilOntology_term=ECO:0000255
TgeneFAM210Achr1:2343830chr18:13666712ENST0000040256324229_271195.0273.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePEX10chr1:2343830chr18:13666712ENST00000288774-16273_31137.333333333333336347.0Zinc fingerRING-type
HgenePEX10chr1:2343830chr18:13666712ENST00000447513-16273_31137.333333333333336327.0Zinc fingerRING-type
TgeneFAM210Achr1:2343830chr18:13666712ENST0000032224735117_229195.0273.0DomainNote=DUF1279
TgeneFAM210Achr1:2343830chr18:13666712ENST0000040256324117_229195.0273.0DomainNote=DUF1279
TgeneFAM210Achr1:2343830chr18:13666712ENST0000032224735136_156195.0273.0TransmembraneHelical
TgeneFAM210Achr1:2343830chr18:13666712ENST0000040256324136_156195.0273.0TransmembraneHelical


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Fusion Gene Sequence for PEX10-FAM210A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000288774_ENST00000322247_TCGA-D7-A4Z0-01A_PEX10_chr1_2343830_-_FAM210A_chr18_13666712_length(transcript)=3507nt_BP=140nt
CTGCTCGGGACCACCCGAACCCGCGGCCATGGCCCCGGCCGCCGCCAGCCCCCCGGAGGTGATCCGCGCGGCGCAGAAGGACGAGTACTA
CCGCGGTGGGCTGCGGAGCGCGGCGGGCGGCGCCCTGCACAGCCTGGCGGATTGCAACACCTGCTCGGTATACCGTGACTTTGGGAGGAA
CATCTGTCACTGTGAAGTATCTGCGCAGTCATGGCTACATGTCCACGCCGCCACCCGTCAAGGAGTATCTGCAGGACAGGATGGAAGAGA
CAAAGGAGCTTATCACAGAGAAAATGGAAGAAACAAAAGATAGACTCACTGAAAAGTTACAAGAAACCAAAGAAAAAGTTTCCTTTAAGA
AAAAAGTGGAATAAGGTGCCTTATATAGCAGTATAGAAAATTCCTGCACTTTAACCCTTTGGAAACTATGGGCAAAGATACATGTGTCTG
ATTATTTTTTTGGTTAGTTGCCGAAATATACTAGTTCTCTGAGGGTTAAAGAAGTAAAATACCTTTTTAAAGTTAAATATCACTAGAAAA
ATCAGTGTTATTACAAGGGAAGAAATGAACCCAGTTTAAGAATTTGCCATCAGTAGCAGTATTAAGCAGTGGTTAATGTCTTAGAAGTCA
GACTTCTTTTTCAAGGTCTTCAGAACCACACTTGATTTCTGTTTTGTTGCAGCTGTAATTGACACATACTAGGCAGCTGACTCCTTGAAT
ATCCAGTGTGACCCATAAAATAGTCTGTTAATACCGGATCTTAATTTTTATGTTATTCATTAAGATTTTAACTATATTCAGTACGTAATT
TGGAGACAAACTAGCATCATCAAAACTGCCTGTAAATAAGGTGTTTAGTCTTTCTATAAAAACAGAATAGAGCAGTTACCTACCAGTTAA
AATATCTTATATGAAGAAAATAGAATAAAGATCCAGTCATATATGTAAATAAGATGTACTGATTGTACGTAAATGAAAAATGGACCCTTT
AAAAATTATTTTTACCTGAAGCTTGTCATAATTTTTTTAAAGCAAATATATATATGGTGATGGTACTTTTCAAAGTGTGTATTAGTGGTG
ATCACCTCAAACATAAACCTCTGTTGTGAATCATTTGTGTCCTTTTCAACTGTCTTTCAGAGGAAAGGTAAAAAATCATTAAACCTTAAA
TTCATTGTTAAAATCAAATATTTGTCAGCAGTAACTCAAGCTCATGGTTCTCAAGCAGAAAAAGGTTTGGGAGACTAAAAATGGAGTCAG
GTTTTCATGGAGACTGCTAACTCCTTGGGGTAGACATGGGCCTTGCCTCAGCAAACCAGTGCAATTTCCCAATGTCTTAGTTTCAGAATT
CATGCTGATTTCATTATGGAGTAAAGTTTTAAATTGTGGCTGCTGCTTTTTGTCTTACATTGAAGGGAAATATCCTTGTTTGAGCATTCT
ACTTGATTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGCCTCCCTCTCTCTCTCCCAGACTGGAGTGCAATGGTACAATCTCGGCTC
ACTGCATCCTCTGCCTCCCAGGTTCAAGTGATCCTCCCGCCTCAGCTTTCCAAGTAGCTGGGAGTATAAGCGTGTGCCACCACACTCAGC
TAATTTTTGTATTTTTAGTGGAGGTGGAGTTTCACCATGTTAGCCAGGCTAGTCTCCAACTCCTGACCTCAGCCTCCCGAGTAGCTGGGA
CTACAGGCGCCCACCACCACGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTAACAAAGCTATCATTAAATC
ATTTGCTTGTAATGAAATTCAGCCGTTGTCAGCTGTGAGCGTTGCGGGGCTGGTGGGGTGTGTTTGAGTATGTAAGTGTCTATTTCCTGT
GCTCTAACAGTGACTATTTCAGTTCTAACCCTTCAATTGCTAATTGGATGAGGGAATGGCCTCTTAGATTGTCCTTGTTTTGACTTATCT
GCTAAGGCGAGAGAATGTCTGGGTTTGCCACACAGTCCCGCAGGGACCCCTGCTCTTTGCCAGGATTTTTATATCAAGTACTTAGTTTGG
CCAAATTTAGAGTATAGTTTAAAGGGGAAAAAAAGTTTGTATTTGATGAGTCTAATTACTATATTAGAATGCTTTTTAAATGAATATGCT
GTGATTGGAATCTCTTCTTGGGGGCCGGGGAGAGTGCTGAGAGATGCAGCTGTGTCTCTGCTCTCTGCAGTCTTGGGCAGGCAGCACCGC
TGTCTCCTGATACAGAGGGTTGAATGCACTGCTTCACATTGATGCCACATTTTCAAATCTAAACATGATTAACATGTTTTTTAAGTATTT
ATCAAATAATTCACATTTTTGCAGGTTTAAGTGCTGTTTTTTAAGATATTAAACATGTTCCTTGTTTCTTTTTTCTTTTTAACCACTGGA
GACTATGTGAAAATCTTGTGTTATATGGAATTTTTCTAAAACAATTTCCTTTTACTTTTCATGTTGCATATTTTCCAGTGGGGATAAATT
GGAGGTTCTTATTACTAATAATCCTGAAACTAAAATTTGCTTTTCCTGCATAGACATCTTTTGTTAGTCCATTTGAGTTTTGTTGCCATC
CAGTTTCATGATCATGTTGTGTTAGTCTAATAGACAATGAGTTACTGCTTGAATGATATGAAATTCTCTAGTAAAAAATGCTCTGAAGAT
GTGAGAAGCTCTGTTGTATTACTTGGCACCAGGAATGTTACAAAAATGTTGTTGCTAGCATATTGCTAACCTAGTCCTTAAGTTTCAGGG
ATTCCTGTAATATGTTGAGTTTGGAGTATTAATAGCAGGCTAACAGAATACAGTACCAATATGCCAAGTTAAATAATTGAGAATATATAC
AGTATAGTTTGCTATGTATAATAGACCTCATTTCATTTACAGTACACCTCACACTTGGGATTAATTCACCTATAACCTCTGTGAACTGCG
AGTGCTCGGCAGAAGCAGCCCTGTGTCTTACATGTCTACATTTATATTTATATTTATATTTATTTTTTTGAGACAGAGTCTCACTCTGTC
ACCCAGGCTAGAGTGCAGTGGCATGATCATAGCTCACTTGCGTCTTGAACTCCTGGCTCAAGTGATCCTCCCACCTCAGCCTGCTGAGTA
GCTGGGACTACAGGTGCACACCACCATGCCTGGCTAAAGGCATGTCTGCATTTATGCGAGGTGTGTTGACCGGGTGGGGAGGGAGCTAGG
ACTGAGATTCGCCTGTGTAAAATGCACAAAAAGGGTTTGCTAAGCAAATTGATATTTGAAATGAAAGATGGATTAGGTGAGAGACTTAGT
TTATTCAGGAATAAGAGCAAAACCAACCACATCAAAAAATGTATTTCACTGAGACAGCCTTTTGTACATACAGCAGGGTGCTGTTTACAG

>In-frame_ENST00000288774_ENST00000322247_TCGA-D7-A4Z0-01A_PEX10_chr1_2343830_-_FAM210A_chr18_13666712_length(amino acids)=104AA_start in transcript=1442_stop in transcript=1756
MIFFFFFFFFETEPPSLSPRLECNGTISAHCILCLPGSSDPPASAFQVAGSISVCHHTQLIFVFLVEVEFHHVSQASLQLLTSASRVAGT

--------------------------------------------------------------
>In-frame_ENST00000447513_ENST00000322247_TCGA-D7-A4Z0-01A_PEX10_chr1_2343830_-_FAM210A_chr18_13666712_length(transcript)=3548nt_BP=181nt
ATCAGTTCTCGCCCGTCTGGGCGTGGGCGTGGCCGGCGTGGCTGCTCGGGACCACCCGAACCCGCGGCCATGGCCCCGGCCGCCGCCAGC
CCCCCGGAGGTGATCCGCGCGGCGCAGAAGGACGAGTACTACCGCGGTGGGCTGCGGAGCGCGGCGGGCGGCGCCCTGCACAGCCTGGCG
GATTGCAACACCTGCTCGGTATACCGTGACTTTGGGAGGAACATCTGTCACTGTGAAGTATCTGCGCAGTCATGGCTACATGTCCACGCC
GCCACCCGTCAAGGAGTATCTGCAGGACAGGATGGAAGAGACAAAGGAGCTTATCACAGAGAAAATGGAAGAAACAAAAGATAGACTCAC
TGAAAAGTTACAAGAAACCAAAGAAAAAGTTTCCTTTAAGAAAAAAGTGGAATAAGGTGCCTTATATAGCAGTATAGAAAATTCCTGCAC
TTTAACCCTTTGGAAACTATGGGCAAAGATACATGTGTCTGATTATTTTTTTGGTTAGTTGCCGAAATATACTAGTTCTCTGAGGGTTAA
AGAAGTAAAATACCTTTTTAAAGTTAAATATCACTAGAAAAATCAGTGTTATTACAAGGGAAGAAATGAACCCAGTTTAAGAATTTGCCA
TCAGTAGCAGTATTAAGCAGTGGTTAATGTCTTAGAAGTCAGACTTCTTTTTCAAGGTCTTCAGAACCACACTTGATTTCTGTTTTGTTG
CAGCTGTAATTGACACATACTAGGCAGCTGACTCCTTGAATATCCAGTGTGACCCATAAAATAGTCTGTTAATACCGGATCTTAATTTTT
ATGTTATTCATTAAGATTTTAACTATATTCAGTACGTAATTTGGAGACAAACTAGCATCATCAAAACTGCCTGTAAATAAGGTGTTTAGT
CTTTCTATAAAAACAGAATAGAGCAGTTACCTACCAGTTAAAATATCTTATATGAAGAAAATAGAATAAAGATCCAGTCATATATGTAAA
TAAGATGTACTGATTGTACGTAAATGAAAAATGGACCCTTTAAAAATTATTTTTACCTGAAGCTTGTCATAATTTTTTTAAAGCAAATAT
ATATATGGTGATGGTACTTTTCAAAGTGTGTATTAGTGGTGATCACCTCAAACATAAACCTCTGTTGTGAATCATTTGTGTCCTTTTCAA
CTGTCTTTCAGAGGAAAGGTAAAAAATCATTAAACCTTAAATTCATTGTTAAAATCAAATATTTGTCAGCAGTAACTCAAGCTCATGGTT
CTCAAGCAGAAAAAGGTTTGGGAGACTAAAAATGGAGTCAGGTTTTCATGGAGACTGCTAACTCCTTGGGGTAGACATGGGCCTTGCCTC
AGCAAACCAGTGCAATTTCCCAATGTCTTAGTTTCAGAATTCATGCTGATTTCATTATGGAGTAAAGTTTTAAATTGTGGCTGCTGCTTT
TTGTCTTACATTGAAGGGAAATATCCTTGTTTGAGCATTCTACTTGATTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGCCTCCCTC
TCTCTCTCCCAGACTGGAGTGCAATGGTACAATCTCGGCTCACTGCATCCTCTGCCTCCCAGGTTCAAGTGATCCTCCCGCCTCAGCTTT
CCAAGTAGCTGGGAGTATAAGCGTGTGCCACCACACTCAGCTAATTTTTGTATTTTTAGTGGAGGTGGAGTTTCACCATGTTAGCCAGGC
TAGTCTCCAACTCCTGACCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCACCACCACGCCCAGCTAATTTTTTTGTATTTTTAGTA
GAGATGGGGTTTCACCATCTTAACAAAGCTATCATTAAATCATTTGCTTGTAATGAAATTCAGCCGTTGTCAGCTGTGAGCGTTGCGGGG
CTGGTGGGGTGTGTTTGAGTATGTAAGTGTCTATTTCCTGTGCTCTAACAGTGACTATTTCAGTTCTAACCCTTCAATTGCTAATTGGAT
GAGGGAATGGCCTCTTAGATTGTCCTTGTTTTGACTTATCTGCTAAGGCGAGAGAATGTCTGGGTTTGCCACACAGTCCCGCAGGGACCC
CTGCTCTTTGCCAGGATTTTTATATCAAGTACTTAGTTTGGCCAAATTTAGAGTATAGTTTAAAGGGGAAAAAAAGTTTGTATTTGATGA
GTCTAATTACTATATTAGAATGCTTTTTAAATGAATATGCTGTGATTGGAATCTCTTCTTGGGGGCCGGGGAGAGTGCTGAGAGATGCAG
CTGTGTCTCTGCTCTCTGCAGTCTTGGGCAGGCAGCACCGCTGTCTCCTGATACAGAGGGTTGAATGCACTGCTTCACATTGATGCCACA
TTTTCAAATCTAAACATGATTAACATGTTTTTTAAGTATTTATCAAATAATTCACATTTTTGCAGGTTTAAGTGCTGTTTTTTAAGATAT
TAAACATGTTCCTTGTTTCTTTTTTCTTTTTAACCACTGGAGACTATGTGAAAATCTTGTGTTATATGGAATTTTTCTAAAACAATTTCC
TTTTACTTTTCATGTTGCATATTTTCCAGTGGGGATAAATTGGAGGTTCTTATTACTAATAATCCTGAAACTAAAATTTGCTTTTCCTGC
ATAGACATCTTTTGTTAGTCCATTTGAGTTTTGTTGCCATCCAGTTTCATGATCATGTTGTGTTAGTCTAATAGACAATGAGTTACTGCT
TGAATGATATGAAATTCTCTAGTAAAAAATGCTCTGAAGATGTGAGAAGCTCTGTTGTATTACTTGGCACCAGGAATGTTACAAAAATGT
TGTTGCTAGCATATTGCTAACCTAGTCCTTAAGTTTCAGGGATTCCTGTAATATGTTGAGTTTGGAGTATTAATAGCAGGCTAACAGAAT
ACAGTACCAATATGCCAAGTTAAATAATTGAGAATATATACAGTATAGTTTGCTATGTATAATAGACCTCATTTCATTTACAGTACACCT
CACACTTGGGATTAATTCACCTATAACCTCTGTGAACTGCGAGTGCTCGGCAGAAGCAGCCCTGTGTCTTACATGTCTACATTTATATTT
ATATTTATATTTATTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTAGAGTGCAGTGGCATGATCATAGCTCACTTGCGTCTTGAA
CTCCTGGCTCAAGTGATCCTCCCACCTCAGCCTGCTGAGTAGCTGGGACTACAGGTGCACACCACCATGCCTGGCTAAAGGCATGTCTGC
ATTTATGCGAGGTGTGTTGACCGGGTGGGGAGGGAGCTAGGACTGAGATTCGCCTGTGTAAAATGCACAAAAAGGGTTTGCTAAGCAAAT
TGATATTTGAAATGAAAGATGGATTAGGTGAGAGACTTAGTTTATTCAGGAATAAGAGCAAAACCAACCACATCAAAAAATGTATTTCAC
TGAGACAGCCTTTTGTACATACAGCAGGGTGCTGTTTACAGATTTCAAGAAAGGAGAAAAAGAATGCTTATACTGAGATTACCTACCTCC

>In-frame_ENST00000447513_ENST00000322247_TCGA-D7-A4Z0-01A_PEX10_chr1_2343830_-_FAM210A_chr18_13666712_length(amino acids)=104AA_start in transcript=1483_stop in transcript=1797
MIFFFFFFFFETEPPSLSPRLECNGTISAHCILCLPGSSDPPASAFQVAGSISVCHHTQLIFVFLVEVEFHHVSQASLQLLTSASRVAGT

--------------------------------------------------------------
>In-frame_ENST00000507596_ENST00000322247_TCGA-D7-A4Z0-01A_PEX10_chr1_2343830_-_FAM210A_chr18_13666712_length(transcript)=3517nt_BP=150nt
GCCGGCGTGGCTGCTCGGGACCACCCGAACCCGCGGCCATGGCCCCGGCCGCCGCCAGCCCCCCGGAGGTGATCCGCGCGGCGCAGAAGG
ACGAGTACTACCGCGGTGGGCTGCGGAGCGCGGCGGGCGGCGCCCTGCACAGCCTGGCGGATTGCAACACCTGCTCGGTATACCGTGACT
TTGGGAGGAACATCTGTCACTGTGAAGTATCTGCGCAGTCATGGCTACATGTCCACGCCGCCACCCGTCAAGGAGTATCTGCAGGACAGG
ATGGAAGAGACAAAGGAGCTTATCACAGAGAAAATGGAAGAAACAAAAGATAGACTCACTGAAAAGTTACAAGAAACCAAAGAAAAAGTT
TCCTTTAAGAAAAAAGTGGAATAAGGTGCCTTATATAGCAGTATAGAAAATTCCTGCACTTTAACCCTTTGGAAACTATGGGCAAAGATA
CATGTGTCTGATTATTTTTTTGGTTAGTTGCCGAAATATACTAGTTCTCTGAGGGTTAAAGAAGTAAAATACCTTTTTAAAGTTAAATAT
CACTAGAAAAATCAGTGTTATTACAAGGGAAGAAATGAACCCAGTTTAAGAATTTGCCATCAGTAGCAGTATTAAGCAGTGGTTAATGTC
TTAGAAGTCAGACTTCTTTTTCAAGGTCTTCAGAACCACACTTGATTTCTGTTTTGTTGCAGCTGTAATTGACACATACTAGGCAGCTGA
CTCCTTGAATATCCAGTGTGACCCATAAAATAGTCTGTTAATACCGGATCTTAATTTTTATGTTATTCATTAAGATTTTAACTATATTCA
GTACGTAATTTGGAGACAAACTAGCATCATCAAAACTGCCTGTAAATAAGGTGTTTAGTCTTTCTATAAAAACAGAATAGAGCAGTTACC
TACCAGTTAAAATATCTTATATGAAGAAAATAGAATAAAGATCCAGTCATATATGTAAATAAGATGTACTGATTGTACGTAAATGAAAAA
TGGACCCTTTAAAAATTATTTTTACCTGAAGCTTGTCATAATTTTTTTAAAGCAAATATATATATGGTGATGGTACTTTTCAAAGTGTGT
ATTAGTGGTGATCACCTCAAACATAAACCTCTGTTGTGAATCATTTGTGTCCTTTTCAACTGTCTTTCAGAGGAAAGGTAAAAAATCATT
AAACCTTAAATTCATTGTTAAAATCAAATATTTGTCAGCAGTAACTCAAGCTCATGGTTCTCAAGCAGAAAAAGGTTTGGGAGACTAAAA
ATGGAGTCAGGTTTTCATGGAGACTGCTAACTCCTTGGGGTAGACATGGGCCTTGCCTCAGCAAACCAGTGCAATTTCCCAATGTCTTAG
TTTCAGAATTCATGCTGATTTCATTATGGAGTAAAGTTTTAAATTGTGGCTGCTGCTTTTTGTCTTACATTGAAGGGAAATATCCTTGTT
TGAGCATTCTACTTGATTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGCCTCCCTCTCTCTCTCCCAGACTGGAGTGCAATGGTACA
ATCTCGGCTCACTGCATCCTCTGCCTCCCAGGTTCAAGTGATCCTCCCGCCTCAGCTTTCCAAGTAGCTGGGAGTATAAGCGTGTGCCAC
CACACTCAGCTAATTTTTGTATTTTTAGTGGAGGTGGAGTTTCACCATGTTAGCCAGGCTAGTCTCCAACTCCTGACCTCAGCCTCCCGA
GTAGCTGGGACTACAGGCGCCCACCACCACGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTAACAAAGCTA
TCATTAAATCATTTGCTTGTAATGAAATTCAGCCGTTGTCAGCTGTGAGCGTTGCGGGGCTGGTGGGGTGTGTTTGAGTATGTAAGTGTC
TATTTCCTGTGCTCTAACAGTGACTATTTCAGTTCTAACCCTTCAATTGCTAATTGGATGAGGGAATGGCCTCTTAGATTGTCCTTGTTT
TGACTTATCTGCTAAGGCGAGAGAATGTCTGGGTTTGCCACACAGTCCCGCAGGGACCCCTGCTCTTTGCCAGGATTTTTATATCAAGTA
CTTAGTTTGGCCAAATTTAGAGTATAGTTTAAAGGGGAAAAAAAGTTTGTATTTGATGAGTCTAATTACTATATTAGAATGCTTTTTAAA
TGAATATGCTGTGATTGGAATCTCTTCTTGGGGGCCGGGGAGAGTGCTGAGAGATGCAGCTGTGTCTCTGCTCTCTGCAGTCTTGGGCAG
GCAGCACCGCTGTCTCCTGATACAGAGGGTTGAATGCACTGCTTCACATTGATGCCACATTTTCAAATCTAAACATGATTAACATGTTTT
TTAAGTATTTATCAAATAATTCACATTTTTGCAGGTTTAAGTGCTGTTTTTTAAGATATTAAACATGTTCCTTGTTTCTTTTTTCTTTTT
AACCACTGGAGACTATGTGAAAATCTTGTGTTATATGGAATTTTTCTAAAACAATTTCCTTTTACTTTTCATGTTGCATATTTTCCAGTG
GGGATAAATTGGAGGTTCTTATTACTAATAATCCTGAAACTAAAATTTGCTTTTCCTGCATAGACATCTTTTGTTAGTCCATTTGAGTTT
TGTTGCCATCCAGTTTCATGATCATGTTGTGTTAGTCTAATAGACAATGAGTTACTGCTTGAATGATATGAAATTCTCTAGTAAAAAATG
CTCTGAAGATGTGAGAAGCTCTGTTGTATTACTTGGCACCAGGAATGTTACAAAAATGTTGTTGCTAGCATATTGCTAACCTAGTCCTTA
AGTTTCAGGGATTCCTGTAATATGTTGAGTTTGGAGTATTAATAGCAGGCTAACAGAATACAGTACCAATATGCCAAGTTAAATAATTGA
GAATATATACAGTATAGTTTGCTATGTATAATAGACCTCATTTCATTTACAGTACACCTCACACTTGGGATTAATTCACCTATAACCTCT
GTGAACTGCGAGTGCTCGGCAGAAGCAGCCCTGTGTCTTACATGTCTACATTTATATTTATATTTATATTTATTTTTTTGAGACAGAGTC
TCACTCTGTCACCCAGGCTAGAGTGCAGTGGCATGATCATAGCTCACTTGCGTCTTGAACTCCTGGCTCAAGTGATCCTCCCACCTCAGC
CTGCTGAGTAGCTGGGACTACAGGTGCACACCACCATGCCTGGCTAAAGGCATGTCTGCATTTATGCGAGGTGTGTTGACCGGGTGGGGA
GGGAGCTAGGACTGAGATTCGCCTGTGTAAAATGCACAAAAAGGGTTTGCTAAGCAAATTGATATTTGAAATGAAAGATGGATTAGGTGA
GAGACTTAGTTTATTCAGGAATAAGAGCAAAACCAACCACATCAAAAAATGTATTTCACTGAGACAGCCTTTTGTACATACAGCAGGGTG
CTGTTTACAGATTTCAAGAAAGGAGAAAAAGAATGCTTATACTGAGATTACCTACCTCCCAGTAGTGAAAATAATAAATTTATCCCTTGA

>In-frame_ENST00000507596_ENST00000322247_TCGA-D7-A4Z0-01A_PEX10_chr1_2343830_-_FAM210A_chr18_13666712_length(amino acids)=104AA_start in transcript=1452_stop in transcript=1766
MIFFFFFFFFETEPPSLSPRLECNGTISAHCILCLPGSSDPPASAFQVAGSISVCHHTQLIFVFLVEVEFHHVSQASLQLLTSASRVAGT

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Fusion Gene PPI Analysis for PEX10-FAM210A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PEX10-FAM210A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PEX10-FAM210A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePEX10C0043459Zellweger Syndrome5CTD_human;GENOMICS_ENGLAND
HgenePEX10C0751594Zellweger-Like Syndrome4CTD_human
HgenePEX10C1832200Peroxisome biogenesis disorders4CTD_human;GENOMICS_ENGLAND
HgenePEX10C3553948PEROXISOME BIOGENESIS DISORDER 6B4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePEX10C3658299Zellweger Spectrum4CTD_human
HgenePEX10C3553947PEROXISOME BIOGENESIS DISORDER 6A (ZELLWEGER)3CTD_human;GENOMICS_ENGLAND