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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PFKP-PSG1 (FusionGDB2 ID:64059)

Fusion Gene Summary for PFKP-PSG1

check button Fusion gene summary
Fusion gene informationFusion gene name: PFKP-PSG1
Fusion gene ID: 64059
HgeneTgene
Gene symbol

PFKP

PSG1

Gene ID

5214

440533

Gene namephosphofructokinase, plateletpregnancy specific beta-1-glycoprotein 8
SynonymsATP-PFK|PFK-C|PFK-P|PFKFPSG1
Cytomap

10p15.2

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent 6-phosphofructokinase, platelet type6-phosphofructokinase type C6-phosphofructokinase, platelet typephosphofructo-1-kinase isozyme Cphosphofructokinase 1phosphohexokinasepregnancy-specific beta-1-glycoprotein 8C1 alternateC2 alternateC3 alternatePS-beta-G-8PSBG-8pregnancy-specific beta-1 glycoproteinpregnancy-specific glycoprotein 8
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000381125, ENST00000381075, 
ENST00000421751, ENST00000381072, 
ENST00000436291, ENST00000595124, 
ENST00000595356, ENST00000403380, 
ENST00000312439, ENST00000244296, 
ENST00000601073, 
Fusion gene scores* DoF score15 X 9 X 3=4053 X 4 X 3=36
# samples 154
** MAII scorelog2(15/405*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PFKP [Title/Abstract] AND PSG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPFKP(3109899)-PSG1(43372507), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PFKP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PSG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A3B3-01APFKPchr10

3109899

-PSG1chr19

43372507

-


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Fusion Gene ORF analysis for PFKP-PSG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000381125ENST00000436291PFKPchr10

3109899

-PSG1chr19

43372507

-
In-frameENST00000381125ENST00000595124PFKPchr10

3109899

-PSG1chr19

43372507

-
In-frameENST00000381125ENST00000595356PFKPchr10

3109899

-PSG1chr19

43372507

-
In-frameENST00000381125ENST00000403380PFKPchr10

3109899

-PSG1chr19

43372507

-
In-frameENST00000381125ENST00000312439PFKPchr10

3109899

-PSG1chr19

43372507

-
In-frameENST00000381125ENST00000244296PFKPchr10

3109899

-PSG1chr19

43372507

-
5CDS-intronENST00000381125ENST00000601073PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000381075ENST00000436291PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000381075ENST00000595124PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000381075ENST00000595356PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000381075ENST00000403380PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000381075ENST00000312439PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000381075ENST00000244296PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-intronENST00000381075ENST00000601073PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000421751ENST00000436291PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000421751ENST00000595124PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000421751ENST00000595356PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000421751ENST00000403380PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000421751ENST00000312439PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000421751ENST00000244296PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-intronENST00000421751ENST00000601073PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000381072ENST00000436291PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000381072ENST00000595124PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000381072ENST00000595356PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000381072ENST00000403380PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000381072ENST00000312439PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-3CDSENST00000381072ENST00000244296PFKPchr10

3109899

-PSG1chr19

43372507

-
intron-intronENST00000381072ENST00000601073PFKPchr10

3109899

-PSG1chr19

43372507

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381125PFKPchr103109899-ENST00000436291PSG1chr1943372507-113018876459127
ENST00000381125PFKPchr103109899-ENST00000595124PSG1chr1943372507-104218876453125
ENST00000381125PFKPchr103109899-ENST00000595356PSG1chr1943372507-103718876453125
ENST00000381125PFKPchr103109899-ENST00000403380PSG1chr1943372507-111118876459127
ENST00000381125PFKPchr103109899-ENST00000312439PSG1chr1943372507-99618876486136
ENST00000381125PFKPchr103109899-ENST00000244296PSG1chr1943372507-133818876480134

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381125ENST00000436291PFKPchr103109899-PSG1chr1943372507-0.0159256770.98407435
ENST00000381125ENST00000595124PFKPchr103109899-PSG1chr1943372507-0.0177517250.9822483
ENST00000381125ENST00000595356PFKPchr103109899-PSG1chr1943372507-0.0179553420.9820447
ENST00000381125ENST00000403380PFKPchr103109899-PSG1chr1943372507-0.0180378090.98196214
ENST00000381125ENST00000312439PFKPchr103109899-PSG1chr1943372507-0.0056859340.9943141
ENST00000381125ENST00000244296PFKPchr103109899-PSG1chr1943372507-0.010402550.9895975

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Fusion Genomic Features for PFKP-PSG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PFKP-PSG1


check button Go to

FGviewer for the breakpoints of chr10:3109899-chr19:43372507

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePSG1chr10:3109899chr19:43372507ENST0000024429635335_410329.3333333333333427.0DomainNote=Ig-like C2-type 3
TgenePSG1chr10:3109899chr19:43372507ENST0000031243936335_410329.3333333333333429.0DomainNote=Ig-like C2-type 3
TgenePSG1chr10:3109899chr19:43372507ENST0000043629136335_410329.3333333333333420.0DomainNote=Ig-like C2-type 3
TgenePSG1chr10:3109899chr19:43372507ENST0000059535636335_410329.3333333333333418.0DomainNote=Ig-like C2-type 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePFKPchr10:3109899chr19:43372507ENST00000381075-124127_1300777.0Nucleotide bindingATP
HgenePFKPchr10:3109899chr19:43372507ENST00000381075-12497_980777.0Nucleotide bindingATP
HgenePFKPchr10:3109899chr19:43372507ENST00000381125-122127_13037.333333333333336785.0Nucleotide bindingATP
HgenePFKPchr10:3109899chr19:43372507ENST00000381125-12297_9837.333333333333336785.0Nucleotide bindingATP
HgenePFKPchr10:3109899chr19:43372507ENST00000381075-124173_1750777.0RegionSubstrate binding
HgenePFKPchr10:3109899chr19:43372507ENST00000381075-1241_3990777.0RegionNote=N-terminal catalytic PFK domain 1
HgenePFKPchr10:3109899chr19:43372507ENST00000381075-124217_2190777.0RegionSubstrate binding
HgenePFKPchr10:3109899chr19:43372507ENST00000381075-124307_3100777.0RegionSubstrate binding
HgenePFKPchr10:3109899chr19:43372507ENST00000381075-124400_4110777.0RegionNote=Interdomain linker
HgenePFKPchr10:3109899chr19:43372507ENST00000381075-124412_7840777.0RegionNote=C-terminal regulatory PFK domain 2
HgenePFKPchr10:3109899chr19:43372507ENST00000381075-124538_5420777.0RegionFructose 2%2C6-bisphosphate binding%3B allosteric activator
HgenePFKPchr10:3109899chr19:43372507ENST00000381075-124583_5850777.0RegionFructose 2%2C6-bisphosphate binding%3B allosteric activator
HgenePFKPchr10:3109899chr19:43372507ENST00000381075-124671_6740777.0RegionFructose 2%2C6-bisphosphate binding%3B allosteric activator
HgenePFKPchr10:3109899chr19:43372507ENST00000381125-122173_17537.333333333333336785.0RegionSubstrate binding
HgenePFKPchr10:3109899chr19:43372507ENST00000381125-1221_39937.333333333333336785.0RegionNote=N-terminal catalytic PFK domain 1
HgenePFKPchr10:3109899chr19:43372507ENST00000381125-122217_21937.333333333333336785.0RegionSubstrate binding
HgenePFKPchr10:3109899chr19:43372507ENST00000381125-122307_31037.333333333333336785.0RegionSubstrate binding
HgenePFKPchr10:3109899chr19:43372507ENST00000381125-122400_41137.333333333333336785.0RegionNote=Interdomain linker
HgenePFKPchr10:3109899chr19:43372507ENST00000381125-122412_78437.333333333333336785.0RegionNote=C-terminal regulatory PFK domain 2
HgenePFKPchr10:3109899chr19:43372507ENST00000381125-122538_54237.333333333333336785.0RegionFructose 2%2C6-bisphosphate binding%3B allosteric activator
HgenePFKPchr10:3109899chr19:43372507ENST00000381125-122583_58537.333333333333336785.0RegionFructose 2%2C6-bisphosphate binding%3B allosteric activator
HgenePFKPchr10:3109899chr19:43372507ENST00000381125-122671_67437.333333333333336785.0RegionFructose 2%2C6-bisphosphate binding%3B allosteric activator
TgenePSG1chr10:3109899chr19:43372507ENST0000024429635149_234329.3333333333333427.0DomainNote=Ig-like C2-type 1
TgenePSG1chr10:3109899chr19:43372507ENST0000024429635240_327329.3333333333333427.0DomainNote=Ig-like C2-type 2
TgenePSG1chr10:3109899chr19:43372507ENST000002442963535_144329.3333333333333427.0DomainNote=Ig-like V-type
TgenePSG1chr10:3109899chr19:43372507ENST0000031243936149_234329.3333333333333429.0DomainNote=Ig-like C2-type 1
TgenePSG1chr10:3109899chr19:43372507ENST0000031243936240_327329.3333333333333429.0DomainNote=Ig-like C2-type 2
TgenePSG1chr10:3109899chr19:43372507ENST000003124393635_144329.3333333333333429.0DomainNote=Ig-like V-type
TgenePSG1chr10:3109899chr19:43372507ENST0000043629136149_234329.3333333333333420.0DomainNote=Ig-like C2-type 1
TgenePSG1chr10:3109899chr19:43372507ENST0000043629136240_327329.3333333333333420.0DomainNote=Ig-like C2-type 2
TgenePSG1chr10:3109899chr19:43372507ENST000004362913635_144329.3333333333333420.0DomainNote=Ig-like V-type
TgenePSG1chr10:3109899chr19:43372507ENST0000059535636149_234329.3333333333333418.0DomainNote=Ig-like C2-type 1
TgenePSG1chr10:3109899chr19:43372507ENST0000059535636240_327329.3333333333333418.0DomainNote=Ig-like C2-type 2
TgenePSG1chr10:3109899chr19:43372507ENST000005953563635_144329.3333333333333418.0DomainNote=Ig-like V-type


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Fusion Gene Sequence for PFKP-PSG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000381125_ENST00000436291_TCGA-FD-A3B3-01A_PFKP_chr10_3109899_-_PSG1_chr19_43372507_length(transcript)=1130nt_BP=188nt
GAGTCAGGCGCGCGCGGGCAGGGTCCCCATTGCCTGCTGCGCACCCGGACGTGCGGCTCCCCTCGGCCTCCTCGCCATGGACGCGGACGA
CTCCCGGGCCCCCAAGGGCTCCTTGCGGAAGTTCCTGGAGCACCTCTCCGGGGCCGGCAAGGCCATCGGCGTGCTGACCAGCGGCGGGGA
TGCTCAAGATGGTCCAGACCTCCCCAGAATTTACCCTTCATTCACCTATTACCGTTCAGGAGAAGTCCTCTACTTGTCCTGTTCTGCGGA
CTCTAACCCACCGGCACAGTATTCTTGGACAATTAATGAAAAGTTTCAGCTACCAGGACAAAAGCTCTTTATCCGCCATATTACTACAAA
GCATAGCGGGCTCTATGTTTGCTCTGTTCGTAACTCAGCCACTGGCAAGGAAAGCTCCAAATCCATGACAGTCGAAGTCTCTGACTGGAC
AGTTCCCTGAATTCTACTAGTACCTCCAATTCCATTTTCTCCCATGGAATCACTAAGAGCAAGACCCACTCTGTTCCAGAAGCCCTATAA
GCTGGAGGTGGACAACTCAATGTAAATTTCATGGGAAAACCCTTGTACGTGAAGCATGAGCCACTCAGAACTCACCAAAATATTCGACAC
CATAACAACAGATGCTCAAACTGTAAACCAGGACAACAAGTGGATGACTTCACACTGTGGACAGTTTTTCCCAAGATGTCAGAACAAGAC
TCCCCATCATGATGAGGCTCTCCCCCCTCTTAACTGTCCTTGCTCATGCCTGCCTCTTTCACTTGGCAGGATAATGCAGTCATTAGAATT
TCACATGTAGTAGCTTCTGAGAGTAACAACAGAGTGTCAGATATGTCATCTCAACCTCAAACTTTTACATAACATCTCAGGGGGAAATGT
GGCTCTCTCCACCTTGCATACAGGGCTCCCAATAGAAATGAACACAGAGATATTGCCTGTGTGTTTGCAGAGAAGATGGTTTGTATGAAG
ACGTAGGAAAGCTGAAATTATAATAGAGTCCCCTTTAAATCCACATTGTGTGGATGGCTCTTGCCGTTTCCTAAGAGATACATTGTAAAA

>In-frame_ENST00000381125_ENST00000436291_TCGA-FD-A3B3-01A_PFKP_chr10_3109899_-_PSG1_chr19_43372507_length(amino acids)=127AA_start in transcript=76_stop in transcript=459
MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQDGPDLPRIYPSFTYYRSGEVLYLSCSADSNPPAQYSWTINEKFQLPGQKLFIR

--------------------------------------------------------------
>In-frame_ENST00000381125_ENST00000595124_TCGA-FD-A3B3-01A_PFKP_chr10_3109899_-_PSG1_chr19_43372507_length(transcript)=1042nt_BP=188nt
GAGTCAGGCGCGCGCGGGCAGGGTCCCCATTGCCTGCTGCGCACCCGGACGTGCGGCTCCCCTCGGCCTCCTCGCCATGGACGCGGACGA
CTCCCGGGCCCCCAAGGGCTCCTTGCGGAAGTTCCTGGAGCACCTCTCCGGGGCCGGCAAGGCCATCGGCGTGCTGACCAGCGGCGGGGA
TGCTCAAGATGGTCCAGACCTCCCCAGAATTTACCCTTCATTCACCTATTACCGTTCAGGAGAAGTCCTCTACTTGTCCTGTTCTGCGGA
CTCTAACCCACCGGCACAGTATTCTTGGACAATTAATGAAAAGTTTCAGCTACCAGGACAAAAGCTCTTTATCCGCCATATTACTACAAA
GCATAGCGGGCTCTATGTTTGCTCTGTTCGTAACTCAGCCACTGGCAAGGAAAGCTCCAAATCCATGACAGTCGAAGTCTCTGAAGCCCT
ATAAGCTGGAGGTGGACAACTCAATGTAAATTTCATGGGAAAACCCTTGTACGTGAAGCATGAGCCACTCAGAACTCACCAAAATATTCG
ACACCATAACAACAGATGCTCAAACTGTAAACCAGGACAACAAGTGGATGACTTCACACTGTGGACAGTTTTTCCCAAGATGTCAGAACA
AGACTCCCCATCATGATGAGGCTCTCCCCCCTCTTAACTGTCCTTGCTCATGCCTGCCTCTTTCACTTGGCAGGATAATGCAGTCATTAG
AATTTCACATGTAGTAGCTTCTGAGAGTAACAACAGAGTGTCAGATATGTCATCTCAACCTCAAACTTTTACATAACATCTCAGGGGGAA
ATGTGGCTCTCTCCACCTTGCATACAGGGCTCCCAATAGAAATGAACACAGAGATATTGCCTGTGTGTTTGCAGAGAAGATGGTTTGTAT
GAAGACGTAGGAAAGCTGAAATTATAATAGAGTCCCCTTTAAATCCACATTGTGTGGATGGCTCTTGCCGTTTCCTAAGAGATACATTGT

>In-frame_ENST00000381125_ENST00000595124_TCGA-FD-A3B3-01A_PFKP_chr10_3109899_-_PSG1_chr19_43372507_length(amino acids)=125AA_start in transcript=76_stop in transcript=453
MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQDGPDLPRIYPSFTYYRSGEVLYLSCSADSNPPAQYSWTINEKFQLPGQKLFIR

--------------------------------------------------------------
>In-frame_ENST00000381125_ENST00000595356_TCGA-FD-A3B3-01A_PFKP_chr10_3109899_-_PSG1_chr19_43372507_length(transcript)=1037nt_BP=188nt
GAGTCAGGCGCGCGCGGGCAGGGTCCCCATTGCCTGCTGCGCACCCGGACGTGCGGCTCCCCTCGGCCTCCTCGCCATGGACGCGGACGA
CTCCCGGGCCCCCAAGGGCTCCTTGCGGAAGTTCCTGGAGCACCTCTCCGGGGCCGGCAAGGCCATCGGCGTGCTGACCAGCGGCGGGGA
TGCTCAAGATGGTCCAGACCTCCCCAGAATTTACCCTTCATTCACCTATTACCGTTCAGGAGAAGTCCTCTACTTGTCCTGTTCTGCGGA
CTCTAACCCACCGGCACAGTATTCTTGGACAATTAATGAAAAGTTTCAGCTACCAGGACAAAAGCTCTTTATCCGCCATATTACTACAAA
GCATAGCGGGCTCTATGTTTGCTCTGTTCGTAACTCAGCCACTGGCAAGGAAAGCTCCAAATCCATGACAGTCGAAGTCTCTGAAGCCCT
ATAAGCTGGAGGTGGACAACTCAATGTAAATTTCATGGGAAAACCCTTGTACGTGAAGCATGAGCCACTCAGAACTCACCAAAATATTCG
ACACCATAACAACAGATGCTCAAACTGTAAACCAGGACAACAAGTGGATGACTTCACACTGTGGACAGTTTTTCCCAAGATGTCAGAACA
AGACTCCCCATCATGATGAGGCTCTCCCCCCTCTTAACTGTCCTTGCTCATGCCTGCCTCTTTCACTTGGCAGGATAATGCAGTCATTAG
AATTTCACATGTAGTAGCTTCTGAGAGTAACAACAGAGTGTCAGATATGTCATCTCAACCTCAAACTTTTACATAACATCTCAGGGGGAA
ATGTGGCTCTCTCCACCTTGCATACAGGGCTCCCAATAGAAATGAACACAGAGATATTGCCTGTGTGTTTGCAGAGAAGATGGTTTGTAT
GAAGACGTAGGAAAGCTGAAATTATAATAGAGTCCCCTTTAAATCCACATTGTGTGGATGGCTCTTGCCGTTTCCTAAGAGATACATTGT

>In-frame_ENST00000381125_ENST00000595356_TCGA-FD-A3B3-01A_PFKP_chr10_3109899_-_PSG1_chr19_43372507_length(amino acids)=125AA_start in transcript=76_stop in transcript=453
MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQDGPDLPRIYPSFTYYRSGEVLYLSCSADSNPPAQYSWTINEKFQLPGQKLFIR

--------------------------------------------------------------
>In-frame_ENST00000381125_ENST00000403380_TCGA-FD-A3B3-01A_PFKP_chr10_3109899_-_PSG1_chr19_43372507_length(transcript)=1111nt_BP=188nt
GAGTCAGGCGCGCGCGGGCAGGGTCCCCATTGCCTGCTGCGCACCCGGACGTGCGGCTCCCCTCGGCCTCCTCGCCATGGACGCGGACGA
CTCCCGGGCCCCCAAGGGCTCCTTGCGGAAGTTCCTGGAGCACCTCTCCGGGGCCGGCAAGGCCATCGGCGTGCTGACCAGCGGCGGGGA
TGCTCAAGATGGTCCAGACCTCCCCAGAATTTACCCTTCATTCACCTATTACCGTTCAGGAGAAGTCCTCTACTTGTCCTGTTCTGCGGA
CTCTAACCCACCGGCACAGTATTCTTGGACAATTAATGAAAAGTTTCAGCTACCAGGACAAAAGCTCTTTATCCGCCATATTACTACAAA
GCATAGCGGGCTCTATGTTTGCTCTGTTCGTAACTCAGCCACTGGCAAGGAAAGCTCCAAATCCATGACAGTCGAAGTCTCTGACTGGAC
AGTTCCCTGAATTCTACTAGTACCTCCAATTCCATTTTCTCCCATGGAATCACTAAGAGCAAGACCCACTCTGTTCCAGAAGCCCTATAA
GCTGGAGGTGGACAACTCAATGTAAATTTCATGGGAAAACCCTTGTACGTGAAGCATGAGCCACTCAGAACTCACCAAAATATTCGACAC
CATAACAACAGATGCTCAAACTGTAAACCAGGACAACAAGTGGATGACTTCACACTGTGGACAGTTTTTCCCAAGATGTCAGAACAAGAC
TCCCCATCATGATGAGGCTCTCCCCCCTCTTAACTGTCCTTGCTCATGCCTGCCTCTTTCACTTGGCAGGATAATGCAGTCATTAGAATT
TCACATGTAGTAGCTTCTGAGAGTAACAACAGAGTGTCAGATATGTCATCTCAACCTCAAACTTTTACATAACATCTCAGGGGGAAATGT
GGCTCTCTCCACCTTGCATACAGGGCTCCCAATAGAAATGAACACAGAGATATTGCCTGTGTGTTTGCAGAGAAGATGGTTTGTATGAAG
ACGTAGGAAAGCTGAAATTATAATAGAGTCCCCTTTAAATCCACATTGTGTGGATGGCTCTTGCCGTTTCCTAAGAGATACATTGTAAAA

>In-frame_ENST00000381125_ENST00000403380_TCGA-FD-A3B3-01A_PFKP_chr10_3109899_-_PSG1_chr19_43372507_length(amino acids)=127AA_start in transcript=76_stop in transcript=459
MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQDGPDLPRIYPSFTYYRSGEVLYLSCSADSNPPAQYSWTINEKFQLPGQKLFIR

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>In-frame_ENST00000381125_ENST00000312439_TCGA-FD-A3B3-01A_PFKP_chr10_3109899_-_PSG1_chr19_43372507_length(transcript)=996nt_BP=188nt
GAGTCAGGCGCGCGCGGGCAGGGTCCCCATTGCCTGCTGCGCACCCGGACGTGCGGCTCCCCTCGGCCTCCTCGCCATGGACGCGGACGA
CTCCCGGGCCCCCAAGGGCTCCTTGCGGAAGTTCCTGGAGCACCTCTCCGGGGCCGGCAAGGCCATCGGCGTGCTGACCAGCGGCGGGGA
TGCTCAAGATGGTCCAGACCTCCCCAGAATTTACCCTTCATTCACCTATTACCGTTCAGGAGAAGTCCTCTACTTGTCCTGTTCTGCGGA
CTCTAACCCACCGGCACAGTATTCTTGGACAATTAATGAAAAGTTTCAGCTACCAGGACAAAAGCTCTTTATCCGCCATATTACTACAAA
GCATAGCGGGCTCTATGTTTGCTCTGTTCGTAACTCAGCCACTGGCAAGGAAAGCTCCAAATCCATGACAGTCGAAGTCTCTGCTTATAG
CAGTTCAATAAACTATACTTCTGGGAACCGTAATTGAAACATTTACTTTTGCTTTCTACCTGACTGCCCCAGAATTGGGCAACTATTCAT
GAGAATTGATATGTTTATGGTAATACACATATTTGCACAAGTACAGTAACAATCTGCTTTCTTTGTAACATGACACATTTGAAATCATTG
GTTATATTACCAATGCTTTGATTCGGATGTTATATTAAAAACATAGATAGAATGAACCAATATGAACTGCAGGCAAAGTCTGAAGTCAGC
CTTGGTTTGGCTTCCTATTCTCAAGAGGTTTGTGAAGATTTAATCTCAGATTCCTTATAAAAACTTAGAGAAAAGAAAATTTTAGAAGAC
AGCCTACATGGTCCATTGCTACTCTTGCTGCACTTATGTAAACAATCAGACCACATTTGAAGAAACTCCACCTATTTTGCAAACAAACTT
ATTCTACTGAAATTATCATTGGTAAAAGTAGAGATGCCCATAGAGGGAAAAATTATGTGGAAAATAAAAACTGTAGTATACCTGTTATGA

>In-frame_ENST00000381125_ENST00000312439_TCGA-FD-A3B3-01A_PFKP_chr10_3109899_-_PSG1_chr19_43372507_length(amino acids)=136AA_start in transcript=76_stop in transcript=486
MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQDGPDLPRIYPSFTYYRSGEVLYLSCSADSNPPAQYSWTINEKFQLPGQKLFIR

--------------------------------------------------------------
>In-frame_ENST00000381125_ENST00000244296_TCGA-FD-A3B3-01A_PFKP_chr10_3109899_-_PSG1_chr19_43372507_length(transcript)=1338nt_BP=188nt
GAGTCAGGCGCGCGCGGGCAGGGTCCCCATTGCCTGCTGCGCACCCGGACGTGCGGCTCCCCTCGGCCTCCTCGCCATGGACGCGGACGA
CTCCCGGGCCCCCAAGGGCTCCTTGCGGAAGTTCCTGGAGCACCTCTCCGGGGCCGGCAAGGCCATCGGCGTGCTGACCAGCGGCGGGGA
TGCTCAAGATGGTCCAGACCTCCCCAGAATTTACCCTTCATTCACCTATTACCGTTCAGGAGAAGTCCTCTACTTGTCCTGTTCTGCGGA
CTCTAACCCACCGGCACAGTATTCTTGGACAATTAATGAAAAGTTTCAGCTACCAGGACAAAAGCTCTTTATCCGCCATATTACTACAAA
GCATAGCGGGCTCTATGTTTGCTCTGTTCGTAACTCAGCCACTGGCAAGGAAAGCTCCAAATCCATGACAGTCGAAGTCTCTGGTAAGTG
GATCCCAGCATCGTTGGCAATAGGGTTTTAGGTGGAGTCTATCTGGCATTCAGAGAAGAGTCAGGAAAACAATTGTATTCCCAGCCTGTG
TCCCATGGGCACAAGCAAATCCCAAATTCTCCTCCTGAACCCTCCAAATTTGTCTAAGAACTTCGAAAACTTTAACAAACAGGCTGATAT
CTTCATAATATTCCCAGCCTAGACCAAGCAGGAAGAACATTGATTTCATTGAAATAATTGATAATAATGAAGATAATGTTTTTATGATTT
TTATTTGAAAATTTGCTGATTCTTTAAATGGTTTGTTTTCTACATTGATGGAATTTTTCTCTTTTAATCTATCTACAGCTTATAGCAGTT
CAATAAACTATACTTCTGGGAACCGTAATTGAAACATTTACTTTTGCTTTCTACCTGACTGCCCCAGAATTGGGCAACTATTCATGAGAA
TTGATATGTTTATGGTAATACACATATTTGCACAAGTACAGTAACAATCTGCTTTCTTTGTAACATGACACATTTGAAATCATTGGTTAT
ATTACCAATGCTTTGATTCGGATGTTATATTAAAAACATAGATAGAATGAACCAATATGAACTGCAGGCAAAGTCTGAAGTCAGCCTTGG
TTTGGCTTCCTATTCTCAAGAGGTTTGTGAAGATTTAATCTCAGATTCCTTATAAAAACTTAGAGAAAAGAAAATTTTAGAAGACAGCCT
ACATGGTCCATTGCTACTCTTGCTGCACTTATGTAAACAATCAGACCACATTTGAAGAAACTCCACCTATTTTGCAAACAAACTTATTCT

>In-frame_ENST00000381125_ENST00000244296_TCGA-FD-A3B3-01A_PFKP_chr10_3109899_-_PSG1_chr19_43372507_length(amino acids)=134AA_start in transcript=76_stop in transcript=480
MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQDGPDLPRIYPSFTYYRSGEVLYLSCSADSNPPAQYSWTINEKFQLPGQKLFIR

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Fusion Gene PPI Analysis for PFKP-PSG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PFKP-PSG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PFKP-PSG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePFKPC0023893Liver Cirrhosis, Experimental1CTD_human