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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGA3-CTSE (FusionGDB2 ID:64089)

Fusion Gene Summary for PGA3-CTSE

check button Fusion gene summary
Fusion gene informationFusion gene name: PGA3-CTSE
Fusion gene ID: 64089
HgeneTgene
Gene symbol

PGA3

CTSE

Gene ID

643834

1510

Gene namepepsinogen A3cathepsin E
Synonyms-CATE
Cytomap

11q12.2

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionpepsin A-3pepsinogen 3, group I (pepsinogen A)pepsinogen-3cathepsin Eerythrocyte membrane aspartic proteinaseslow-moving proteinase
Modification date2020031320200313
UniProtAcc.

P14091

Ensembl transtripts involved in fusion geneENST00000325558, ENST00000543125, 
ENST00000538258, 		ENST00000361052, 
ENST00000358184, ENST00000360218, 
ENST00000432969, ENST00000468617, 
Fusion gene scores* DoF score15 X 13 X 4=7803 X 3 X 2=18
# samples 163
** MAII scorelog2(16/780*10)=-2.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PGA3 [Title/Abstract] AND CTSE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGA3(60971741)-CTSE(206319100), # samples:9
CTSE(206318467)-PGA3(60973981), # samples:3
Anticipated loss of major functional domain due to fusion event.PGA3-CTSE seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PGA3-CTSE seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCTSE

GO:0006508

proteolysis

16997486

TgeneCTSE

GO:0019886

antigen processing and presentation of exogenous peptide antigen via MHC class II

8765029


check buttonFusion gene breakpoints across PGA3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CTSE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-L5-A4OJ-11APGA3chr11

60978907

+CTSEchr1

206331020

+
ChimerDB4Non-CancerTCGA-L5-A4OJ-11APGA3chr11

60978907

+CTSEchr1

206331020

+
ChimerDB4Non-CancerTCGA-BR-8060-11APGA3chr11

60971741

+CTSEchr1

206319100

+
ChimerDB4Non-Cancer139NPGA3chr11

60971741

+CTSEchr1

206319100

+
ChimerDB4Non-Cancer203NPGA3chr11

60971741

+CTSEchr1

206319100

+
ChimerDB4Non-Cancer267NPGA3chr11

60971741

+CTSEchr1

206319100

+
ChimerDB4Non-Cancer43NPGA3chr11

60971741

+CTSEchr1

206319100

+
ChimerDB4Non-Cancer5263NPGA3chr11

60971741

+CTSEchr1

206319100

+
ChimerDB4Non-Cancer5357NPGA3chr11

60971741

+CTSEchr1

206319100

+
ChimerDB4Non-Cancer5381NPGA3chr11

60971741

+CTSEchr1

206319100

+
ChimerDB4Non-Cancer5759NPGA3chr11

60971741

+CTSEchr1

206319100

+


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Fusion Gene ORF analysis for PGA3-CTSE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000325558ENST00000361052PGA3chr11

60978907

+CTSEchr1

206331020

+
Frame-shiftENST00000325558ENST00000358184PGA3chr11

60978907

+CTSEchr1

206331020

+
Frame-shiftENST00000325558ENST00000360218PGA3chr11

60978907

+CTSEchr1

206331020

+
Frame-shiftENST00000325558ENST00000432969PGA3chr11

60978907

+CTSEchr1

206331020

+
5CDS-intronENST00000325558ENST00000468617PGA3chr11

60978907

+CTSEchr1

206331020

+
Frame-shiftENST00000543125ENST00000361052PGA3chr11

60978907

+CTSEchr1

206331020

+
Frame-shiftENST00000543125ENST00000358184PGA3chr11

60978907

+CTSEchr1

206331020

+
Frame-shiftENST00000543125ENST00000360218PGA3chr11

60978907

+CTSEchr1

206331020

+
Frame-shiftENST00000543125ENST00000432969PGA3chr11

60978907

+CTSEchr1

206331020

+
5CDS-intronENST00000543125ENST00000468617PGA3chr11

60978907

+CTSEchr1

206331020

+
Frame-shiftENST00000538258ENST00000361052PGA3chr11

60978907

+CTSEchr1

206331020

+
Frame-shiftENST00000538258ENST00000358184PGA3chr11

60978907

+CTSEchr1

206331020

+
Frame-shiftENST00000538258ENST00000360218PGA3chr11

60978907

+CTSEchr1

206331020

+
Frame-shiftENST00000538258ENST00000432969PGA3chr11

60978907

+CTSEchr1

206331020

+
5CDS-intronENST00000538258ENST00000468617PGA3chr11

60978907

+CTSEchr1

206331020

+
In-frameENST00000325558ENST00000361052PGA3chr11

60971741

+CTSEchr1

206319100

+
In-frameENST00000325558ENST00000358184PGA3chr11

60971741

+CTSEchr1

206319100

+
In-frameENST00000325558ENST00000360218PGA3chr11

60971741

+CTSEchr1

206319100

+
In-frameENST00000325558ENST00000432969PGA3chr11

60971741

+CTSEchr1

206319100

+
5CDS-intronENST00000325558ENST00000468617PGA3chr11

60971741

+CTSEchr1

206319100

+
intron-3CDSENST00000543125ENST00000361052PGA3chr11

60971741

+CTSEchr1

206319100

+
intron-3CDSENST00000543125ENST00000358184PGA3chr11

60971741

+CTSEchr1

206319100

+
intron-3CDSENST00000543125ENST00000360218PGA3chr11

60971741

+CTSEchr1

206319100

+
intron-3CDSENST00000543125ENST00000432969PGA3chr11

60971741

+CTSEchr1

206319100

+
intron-intronENST00000543125ENST00000468617PGA3chr11

60971741

+CTSEchr1

206319100

+
intron-3CDSENST00000538258ENST00000361052PGA3chr11

60971741

+CTSEchr1

206319100

+
intron-3CDSENST00000538258ENST00000358184PGA3chr11

60971741

+CTSEchr1

206319100

+
intron-3CDSENST00000538258ENST00000360218PGA3chr11

60971741

+CTSEchr1

206319100

+
intron-3CDSENST00000538258ENST00000432969PGA3chr11

60971741

+CTSEchr1

206319100

+
intron-intronENST00000538258ENST00000468617PGA3chr11

60971741

+CTSEchr1

206319100

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000325558PGA3chr1160971741+ENST00000361052CTSEchr1206319100+23044041311384417
ENST00000325558PGA3chr1160971741+ENST00000358184CTSEchr1206319100+22894041311369412
ENST00000325558PGA3chr1160971741+ENST00000360218CTSEchr1206319100+21464041311270379
ENST00000325558PGA3chr1160971741+ENST00000432969CTSEchr1206319100+16034041311270379

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000325558ENST00000361052PGA3chr1160971741+CTSEchr1206319100+0.000660420.9993395
ENST00000325558ENST00000358184PGA3chr1160971741+CTSEchr1206319100+0.0006506870.9993493
ENST00000325558ENST00000360218PGA3chr1160971741+CTSEchr1206319100+0.0048851170.9951149
ENST00000325558ENST00000432969PGA3chr1160971741+CTSEchr1206319100+0.0090755760.9909244

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Fusion Genomic Features for PGA3-CTSE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PGA3chr1160978907+CTSEchr1206331020+0.999832030.000167916
PGA3chr1160971741+CTSEchr1206319100+0.000128870.99987113
PGA3chr1160978907+CTSEchr1206331020+0.999832030.000167916
PGA3chr1160971741+CTSEchr1206319100+0.000128870.99987113

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGA3-CTSE


check button Go to

FGviewer for the breakpoints of chr11:60971741-chr1:206319100

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CTSE

P14091

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. {ECO:0000269|PubMed:8765029}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCTSEchr11:60971741chr1:206319100ENST000003581841978_39675.0397.0DomainPeptidase A1
TgeneCTSEchr11:60971741chr1:206319100ENST000003602181878_39675.0364.0DomainPeptidase A1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGA3chr11:60971741chr1:206319100ENST00000325558+2976_38573.0389.0DomainPeptidase A1


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Fusion Gene Sequence for PGA3-CTSE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000325558_ENST00000361052_TCGA-BR-8060-11A_PGA3_chr11_60971741_+_CTSE_chr1_206319100_length(transcript)=2304nt_BP=404nt
TCAGAATGTGGCTTAGGGCAGCCACAATCTTATCAGGAGCTTCTCTGTTTGGGATCAGGGGAACCGGTGACTTTCAGAGGCCGATAAGGC
GGGACCCAACTTGTATATAAGGGGCAGCTCATGCTGCTGCTCTGCACCTTCCTCCCGTCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAA
GAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCACTCTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGA
GGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGAAGG
CTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATATGGAATACTTCGGCACTATCTCCATTGGCTCCCCACCACAGAACT
TCACTGTCATCTTCGACACTGGCTCCTCCAACCTCTGGGTCCCCTCTGTGTACTGCACTAGCCCAGCCTGCAAGACGCACAGCAGGTTCC
AGCCTTCCCAGTCCAGCACATACAGCCAGCCAGGTCAATCTTTCTCCATTCAGTATGGAACCGGGAGCTTGTCCGGGATCATTGGAGCCG
ACCAAGTCTCTGCTTTCTCCTACCAGGTGGAAGGACTAACCGTGGTTGGCCAGCAGTTTGGAGAAAGTGTCACAGAGCCAGGCCAGACCT
TTGTGGATGCAGAGTTTGATGGAATTCTGGGCCTGGGATACCCCTCCTTGGCTGTGGGAGGAGTGACTCCAGTATTTGACAACATGATGG
CTCAGAACCTGGTGGACTTGCCGATGTTTTCTGTCTACATGAGCAGTAACCCAGAAGGTGGTGCGGGGAGCGAGCTGATTTTTGGAGGCT
ACGACCACTCCCATTTCTCTGGGAGCCTGAATTGGGTCCCAGTCACCAAGCAAGCTTACTGGCAGATTGCACTGGATAACATCCAGGTGG
GAGGCACTGTTATGTTCTGCTCCGAGGGCTGCCAGGCCATTGTGGACACAGGGACTTCCCTCATCACTGGCCCTTCCGACAAGATTAAGC
AGCTGCAAAACGCCATTGGGGCAGCCCCCGTGGATGGAGAATATGCTGTGGAGTGTGCCAACCTTAACGTCATGCCGGATGTCACCTTCA
CCATTAACGGAGTCCCCTATACCCTCAGCCCAACTGCCTACACCCTACTGGACTTCGTGGATGGAATGCAGTTCTGCAGCAGTGGCTTTC
AAGGACTTGACATCCACCCTCCAGCTGGGCCCCTCTGGATCCTGGGGGATGTCTTCATTCGACAGTTTTACTCAGTCTTTGACCGTGGGA
ATAACCGTGTGGGACTGGCCCCAGCAGTCCCCTAAGGAGGGGCCTTGTGTCTGTGCCTGCCTGTCTGACAGACCTTGAATATGTTAGGCT
GGGGCATTCTTTACACCTACAAAAAGTTATTTTCCAGAGAATGTAGCTGTTTCCAGGGTTGCAACTTGAATTAAGACCAAACAGAACATG
AGAATACACACACACACACACATATACACACACACACACTTCACACATACACACCACTCCCACCACCGTCATGATGGAGGAATTACGTTA
TACATTCATATTTTGTATTGATTTTTGATTATGAAAATCAAAAATTTTCACATTTGATTATGAAAATCTCCAAACATATGCACAAGCAGA
GATCATGGTATAATAAATCCCTTTGCAACTCCACTCAGCCCTGACAACCCATCCACACACGGCCAGGCCTGTTTATCTACACTGCTGCCC
ACTCCTCTCTCCAGCTCCACATGCTGTACCTGGATCATTCTGAAGCAAATTCCGAGCATTACATCATTTTGTCCATAAATATTTCTAACA
TCCTTAAATATACAATCGGAATTCAAGCATCTCCCATTGTCCCACAAATGTTTGGCTGTTTTTGTAGTTGGATTGTTTGTATTAGGATTC
AAGCAAGGCCCATATATTGCATTTATTTGAAATGTCTGTAAGTCTCTTTCCATCTACAGAGTTTAGCACATTTGAACGTTGCTGGTTGAA
ATCCCGAGGTGTCATTTGACATGGTTCTCTGAACTTATCTTTCCTATAAAATGGTAGTTAGATCTGGAGGTCTGATTTTGTGGCAAAAAT
ACTTCCTAGGTGGTGCTGGGTACTTCTTGTTGCATCCTGTCAGGAGGCAGATAATGCTGGTGCCTCTCTATTGGTAATGTTAAGACTGCT

>In-frame_ENST00000325558_ENST00000361052_TCGA-BR-8060-11A_PGA3_chr11_60971741_+_CTSE_chr1_206319100_length(amino acids)=417AA_start in transcript=131_stop in transcript=1384
MHLPPVLPSPSSWDPGRTMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLENYL
DMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFSYQVEGLT
VVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVP
VTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAY

--------------------------------------------------------------
>In-frame_ENST00000325558_ENST00000358184_TCGA-BR-8060-11A_PGA3_chr11_60971741_+_CTSE_chr1_206319100_length(transcript)=2289nt_BP=404nt
TCAGAATGTGGCTTAGGGCAGCCACAATCTTATCAGGAGCTTCTCTGTTTGGGATCAGGGGAACCGGTGACTTTCAGAGGCCGATAAGGC
GGGACCCAACTTGTATATAAGGGGCAGCTCATGCTGCTGCTCTGCACCTTCCTCCCGTCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAA
GAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCACTCTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGA
GGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGAAGG
CTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATATGGAATACTTCGGCACTATCTCCATTGGCTCCCCACCACAGAACT
TCACTGTCATCTTCGACACTGGCTCCTCCAACCTCTGGGTCCCCTCTGTGTACTGCACTAGCCCAGCCTGCAAGACGCACAGCAGGTTCC
AGCCTTCCCAGTCCAGCACATACAGCCAGCCAGGTCAATCTTTCTCCATTCAGTATGGAACCGGGAGCTTGTCCGGGATCATTGGAGCCG
ACCAAGTCTCTGTGGAAGGACTAACCGTGGTTGGCCAGCAGTTTGGAGAAAGTGTCACAGAGCCAGGCCAGACCTTTGTGGATGCAGAGT
TTGATGGAATTCTGGGCCTGGGATACCCCTCCTTGGCTGTGGGAGGAGTGACTCCAGTATTTGACAACATGATGGCTCAGAACCTGGTGG
ACTTGCCGATGTTTTCTGTCTACATGAGCAGTAACCCAGAAGGTGGTGCGGGGAGCGAGCTGATTTTTGGAGGCTACGACCACTCCCATT
TCTCTGGGAGCCTGAATTGGGTCCCAGTCACCAAGCAAGCTTACTGGCAGATTGCACTGGATAACATCCAGGTGGGAGGCACTGTTATGT
TCTGCTCCGAGGGCTGCCAGGCCATTGTGGACACAGGGACTTCCCTCATCACTGGCCCTTCCGACAAGATTAAGCAGCTGCAAAACGCCA
TTGGGGCAGCCCCCGTGGATGGAGAATATGCTGTGGAGTGTGCCAACCTTAACGTCATGCCGGATGTCACCTTCACCATTAACGGAGTCC
CCTATACCCTCAGCCCAACTGCCTACACCCTACTGGACTTCGTGGATGGAATGCAGTTCTGCAGCAGTGGCTTTCAAGGACTTGACATCC
ACCCTCCAGCTGGGCCCCTCTGGATCCTGGGGGATGTCTTCATTCGACAGTTTTACTCAGTCTTTGACCGTGGGAATAACCGTGTGGGAC
TGGCCCCAGCAGTCCCCTAAGGAGGGGCCTTGTGTCTGTGCCTGCCTGTCTGACAGACCTTGAATATGTTAGGCTGGGGCATTCTTTACA
CCTACAAAAAGTTATTTTCCAGAGAATGTAGCTGTTTCCAGGGTTGCAACTTGAATTAAGACCAAACAGAACATGAGAATACACACACAC
ACACACATATACACACACACACACTTCACACATACACACCACTCCCACCACCGTCATGATGGAGGAATTACGTTATACATTCATATTTTG
TATTGATTTTTGATTATGAAAATCAAAAATTTTCACATTTGATTATGAAAATCTCCAAACATATGCACAAGCAGAGATCATGGTATAATA
AATCCCTTTGCAACTCCACTCAGCCCTGACAACCCATCCACACACGGCCAGGCCTGTTTATCTACACTGCTGCCCACTCCTCTCTCCAGC
TCCACATGCTGTACCTGGATCATTCTGAAGCAAATTCCGAGCATTACATCATTTTGTCCATAAATATTTCTAACATCCTTAAATATACAA
TCGGAATTCAAGCATCTCCCATTGTCCCACAAATGTTTGGCTGTTTTTGTAGTTGGATTGTTTGTATTAGGATTCAAGCAAGGCCCATAT
ATTGCATTTATTTGAAATGTCTGTAAGTCTCTTTCCATCTACAGAGTTTAGCACATTTGAACGTTGCTGGTTGAAATCCCGAGGTGTCAT
TTGACATGGTTCTCTGAACTTATCTTTCCTATAAAATGGTAGTTAGATCTGGAGGTCTGATTTTGTGGCAAAAATACTTCCTAGGTGGTG
CTGGGTACTTCTTGTTGCATCCTGTCAGGAGGCAGATAATGCTGGTGCCTCTCTATTGGTAATGTTAAGACTGCTGGGTGGGTTTGGAGT

>In-frame_ENST00000325558_ENST00000358184_TCGA-BR-8060-11A_PGA3_chr11_60971741_+_CTSE_chr1_206319100_length(amino acids)=412AA_start in transcript=131_stop in transcript=1369
MHLPPVLPSPSSWDPGRTMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLENYL
DMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQ
FGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQA
YWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDF

--------------------------------------------------------------
>In-frame_ENST00000325558_ENST00000360218_TCGA-BR-8060-11A_PGA3_chr11_60971741_+_CTSE_chr1_206319100_length(transcript)=2146nt_BP=404nt
TCAGAATGTGGCTTAGGGCAGCCACAATCTTATCAGGAGCTTCTCTGTTTGGGATCAGGGGAACCGGTGACTTTCAGAGGCCGATAAGGC
GGGACCCAACTTGTATATAAGGGGCAGCTCATGCTGCTGCTCTGCACCTTCCTCCCGTCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAA
GAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCACTCTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGA
GGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGAAGG
CTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATATGGAATACTTCGGCACTATCTCCATTGGCTCCCCACCACAGAACT
TCACTGTCATCTTCGACACTGGCTCCTCCAACCTCTGGGTCCCCTCTGTGTACTGCACTAGCCCAGCCTGCAAGACGCACAGCAGGTTCC
AGCCTTCCCAGTCCAGCACATACAGCCAGCCAGGTCAATCTTTCTCCATTCAGTATGGAACCGGGAGCTTGTCCGGGATCATTGGAGCCG
ACCAAGTCTCTGTGGAAGGACTAACCGTGGTTGGCCAGCAGTTTGGAGAAAGTGTCACAGAGCCAGGCCAGACCTTTGTGGATGCAGAGT
TTGATGGAATTCTGGGCCTGGGATACCCCTCCTTGGCTGTGGGAGGAGTGACTCCAGTATTTGACAACATGATGGCTCAGAACCTGGTGG
ACTTGCCGATGTTTTCTGTCTACATGAGCAGTAACCCAGAAGGTGGTGCGGGGAGCGAGCTGATTTTTGGAGGCTACGACCACTCCCATT
TCTCTGGGAGCCTGAATTGGGTCCCAGTCACCAAGCAAGCTTACTGGCAGATTGCACTGGATAATATGCTGTGGAGTGTGCCAACCTTAA
CGTCATGCCGGATGTCACCTTCACCATTAACGGAGTCCCCTATACCCTCAGCCCAACTGCCTACACCCTACTGGACTTCGTGGATGGAAT
GCAGTTCTGCAGCAGTGGCTTTCAAGGACTTGACATCCACCCTCCAGCTGGGCCCCTCTGGATCCTGGGGGATGTCTTCATTCGACAGTT
TTACTCAGTCTTTGACCGTGGGAATAACCGTGTGGGACTGGCCCCAGCAGTCCCCTAAGGAGGGGCCTTGTGTCTGTGCCTGCCTGTCTG
ACAGACCTTGAATATGTTAGGCTGGGGCATTCTTTACACCTACAAAAAGTTATTTTCCAGAGAATGTAGCTGTTTCCAGGGTTGCAACTT
GAATTAAGACCAAACAGAACATGAGAATACACACACACACACACATATACACACACACACACTTCACACATACACACCACTCCCACCACC
GTCATGATGGAGGAATTACGTTATACATTCATATTTTGTATTGATTTTTGATTATGAAAATCAAAAATTTTCACATTTGATTATGAAAAT
CTCCAAACATATGCACAAGCAGAGATCATGGTATAATAAATCCCTTTGCAACTCCACTCAGCCCTGACAACCCATCCACACACGGCCAGG
CCTGTTTATCTACACTGCTGCCCACTCCTCTCTCCAGCTCCACATGCTGTACCTGGATCATTCTGAAGCAAATTCCGAGCATTACATCAT
TTTGTCCATAAATATTTCTAACATCCTTAAATATACAATCGGAATTCAAGCATCTCCCATTGTCCCACAAATGTTTGGCTGTTTTTGTAG
TTGGATTGTTTGTATTAGGATTCAAGCAAGGCCCATATATTGCATTTATTTGAAATGTCTGTAAGTCTCTTTCCATCTACAGAGTTTAGC
ACATTTGAACGTTGCTGGTTGAAATCCCGAGGTGTCATTTGACATGGTTCTCTGAACTTATCTTTCCTATAAAATGGTAGTTAGATCTGG
AGGTCTGATTTTGTGGCAAAAATACTTCCTAGGTGGTGCTGGGTACTTCTTGTTGCATCCTGTCAGGAGGCAGATAATGCTGGTGCCTCT

>In-frame_ENST00000325558_ENST00000360218_TCGA-BR-8060-11A_PGA3_chr11_60971741_+_CTSE_chr1_206319100_length(amino acids)=379AA_start in transcript=131_stop in transcript=1270
MHLPPVLPSPSSWDPGRTMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLENYL
DMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQ
FGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQA
YWQIALDNMLWSVPTLTSCRMSPSPLTESPIPSAQLPTPYWTSWMECSSAAVAFKDLTSTLQLGPSGSWGMSSFDSFTQSLTVGITVWDW

--------------------------------------------------------------
>In-frame_ENST00000325558_ENST00000432969_TCGA-BR-8060-11A_PGA3_chr11_60971741_+_CTSE_chr1_206319100_length(transcript)=1603nt_BP=404nt
TCAGAATGTGGCTTAGGGCAGCCACAATCTTATCAGGAGCTTCTCTGTTTGGGATCAGGGGAACCGGTGACTTTCAGAGGCCGATAAGGC
GGGACCCAACTTGTATATAAGGGGCAGCTCATGCTGCTGCTCTGCACCTTCCTCCCGTCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAA
GAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCACTCTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGA
GGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGAAGG
CTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATATGGAATACTTCGGCACTATCTCCATTGGCTCCCCACCACAGAACT
TCACTGTCATCTTCGACACTGGCTCCTCCAACCTCTGGGTCCCCTCTGTGTACTGCACTAGCCCAGCCTGCAAGACGCACAGCAGGTTCC
AGCCTTCCCAGTCCAGCACATACAGCCAGCCAGGTCAATCTTTCTCCATTCAGTATGGAACCGGGAGCTTGTCCGGGATCATTGGAGCCG
ACCAAGTCTCTGTGGAAGGACTAACCGTGGTTGGCCAGCAGTTTGGAGAAAGTGTCACAGAGCCAGGCCAGACCTTTGTGGATGCAGAGT
TTGATGGAATTCTGGGCCTGGGATACCCCTCCTTGGCTGTGGGAGGAGTGACTCCAGTATTTGACAACATGATGGCTCAGAACCTGGTGG
ACTTGCCGATGTTTTCTGTCTACATGAGCAGTAACCCAGAAGGTGGTGCGGGGAGCGAGCTGATTTTTGGAGGCTACGACCACTCCCATT
TCTCTGGGAGCCTGAATTGGGTCCCAGTCACCAAGCAAGCTTACTGGCAGATTGCACTGGATAATATGCTGTGGAGTGTGCCAACCTTAA
CGTCATGCCGGATGTCACCTTCACCATTAACGGAGTCCCCTATACCCTCAGCCCAACTGCCTACACCCTACTGGACTTCGTGGATGGAAT
GCAGTTCTGCAGCAGTGGCTTTCAAGGACTTGACATCCACCCTCCAGCTGGGCCCCTCTGGATCCTGGGGGATGTCTTCATTCGACAGTT
TTACTCAGTCTTTGACCGTGGGAATAACCGTGTGGGACTGGCCCCAGCAGTCCCCTAAGGAGGGGCCTTGTGTCTGTGCCTGCCTGTCTG
ACAGACCTTGAATATGTTAGGCTGGGGCATTCTTTACACCTACAAAAAGTTATTTTCCAGAGAATGTAGCTGTTTCCAGGGTTGCAACTT
GAATTAAGACCAAACAGAACATGAGAATACACACACACACACACATATACACACACACACACTTCACACATACACACCACTCCCACCACC
GTCATGATGGAGGAATTACGTTATACATTCATATTTTGTATTGATTTTTGATTATGAAAATCAAAAATTTTCACATTTGATTATGAAAAT

>In-frame_ENST00000325558_ENST00000432969_TCGA-BR-8060-11A_PGA3_chr11_60971741_+_CTSE_chr1_206319100_length(amino acids)=379AA_start in transcript=131_stop in transcript=1270
MHLPPVLPSPSSWDPGRTMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLENYL
DMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQ
FGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQA
YWQIALDNMLWSVPTLTSCRMSPSPLTESPIPSAQLPTPYWTSWMECSSAAVAFKDLTSTLQLGPSGSWGMSSFDSFTQSLTVGITVWDW

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Fusion Gene PPI Analysis for PGA3-CTSE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGA3-CTSE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGA3-CTSE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCTSEC0019193Hepatitis, Toxic1CTD_human
TgeneCTSEC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCTSEC0860207Drug-Induced Liver Disease1CTD_human
TgeneCTSEC1262760Hepatitis, Drug-Induced1CTD_human
TgeneCTSEC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneCTSEC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneCTSEC4279912Chemically-Induced Liver Toxicity1CTD_human