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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGA3-PGC (FusionGDB2 ID:64099)

Fusion Gene Summary for PGA3-PGC

check button Fusion gene summary
Fusion gene informationFusion gene name: PGA3-PGC
Fusion gene ID: 64099
HgeneTgene
Gene symbol

PGA3

PGC

Gene ID

643834

5225

Gene namepepsinogen A3progastricsin
Synonyms-PEPC|PGII
Cytomap

11q12.2

6p21.1

Type of geneprotein-codingprotein-coding
Descriptionpepsin A-3pepsinogen 3, group I (pepsinogen A)pepsinogen-3gastricsinpepsin Cpepsinogen Cpepsinogen group IIpreprogastricsin
Modification date2020031320200313
UniProtAcc.

PERM1

Ensembl transtripts involved in fusion geneENST00000325558, ENST00000543125, 
ENST00000538258, 		ENST00000373025, 
ENST00000425343, 
Fusion gene scores* DoF score15 X 13 X 4=78024 X 21 X 8=4032
# samples 1625
** MAII scorelog2(16/780*10)=-2.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/4032*10)=-4.01149563883783
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGA3 [Title/Abstract] AND PGC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGA3(60974099)-PGC(41711127), # samples:18
PGC(41710027)-PGA3(60977313), # samples:13
Anticipated loss of major functional domain due to fusion event.PGA3-PGC seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PGA3-PGC seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PGC-PGA3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PGC-PGA3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PGA3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PGC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-L5-A43C-11APGA3chr11

60971741

+PGCchr6

41705566

-
ChimerDB4Non-CancerTCGA-L5-A43C-11APGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-CancerTCGA-L5-A43C-11APGA3chr11

60971741

+PGCchr6

41712252

-
ChimerDB4Non-CancerTCGA-L5-A4OG-11APGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-CancerTCGA-L5-A43C-11APGA3chr11

60971741

+PGCchr6

41712252

-
ChimerDB4Non-CancerTCGA-L5-A43C-11APGA3chr11

60971741

+PGCchr6

41705566

-
ChimerDB4Non-CancerTCGA-BR-8060-11APGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer115NdPGA3chr11

60971741

+PGCchr6

41712252

-
ChimerDB4Non-Cancer115NdPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer115NdPGA3chr11

60974099

+PGCchr6

41712252

-
ChimerDB4Non-Cancer115NdPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer115NdPGA3chr11

60978907

+PGCchr6

41704742

-
ChimerDB4Non-Cancer117NdPGA3chr11

60971741

+PGCchr6

41705566

-
ChimerDB4Non-Cancer117NdPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer117NdPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer117NdPGA3chr11

60978907

+PGCchr6

41711127

-
ChimerDB4Non-Cancer119NdPGA3chr11

60971741

+PGCchr6

41712252

-
ChimerDB4Non-Cancer119NdPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer119NdPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer123NdPGA3chr11

60971741

+PGCchr6

41712252

-
ChimerDB4Non-Cancer123NdPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer123NdPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer123NdPGA3chr11

60978907

+PGCchr6

41704742

-
ChimerDB4Non-Cancer131NdPGA3chr11

60971741

+PGCchr6

41712252

-
ChimerDB4Non-Cancer131NdPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer131NdPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer139NPGA3chr11

60971741

+PGCchr6

41712252

-
ChimerDB4Non-Cancer139NPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer145NPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer203NPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer203NPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer217NPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer217NPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer231NPGA3chr11

60971741

+PGCchr6

41712252

-
ChimerDB4Non-Cancer231NPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer231NPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer2397NPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer267NPGA3chr11

60971741

+PGCchr6

41712252

-
ChimerDB4Non-Cancer267NPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer267NPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer5263NPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer5263NPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer5357NPGA3chr11

60971741

+PGCchr6

41712252

-
ChimerDB4Non-Cancer5357NPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer5357NPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer5381NPGA3chr11

60971741

+PGCchr6

41712252

-
ChimerDB4Non-Cancer5381NPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer5381NPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-Cancer5759NPGA3chr11

60971741

+PGCchr6

41712252

-
ChimerDB4Non-Cancer5759NPGA3chr11

60974099

+PGCchr6

41711127

-
ChimerDB4Non-Cancer5759NPGA3chr11

60975962

+PGCchr6

41708348

-
ChimerDB4Non-CancerTCGA-BR-6458-11APGA3chr11

60997445

+PGCchr6

41707626

-
ChimerDB4Non-CancerTCGA-BR-6458-11APGA3chr11

60974099

+PGCchr6

41711127

-


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Fusion Gene ORF analysis for PGA3-PGC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000325558ENST00000373025PGA3chr11

60971741

+PGCchr6

41705566

-
5CDS-intronENST00000325558ENST00000425343PGA3chr11

60971741

+PGCchr6

41705566

-
intron-3CDSENST00000543125ENST00000373025PGA3chr11

60971741

+PGCchr6

41705566

-
intron-intronENST00000543125ENST00000425343PGA3chr11

60971741

+PGCchr6

41705566

-
intron-3CDSENST00000538258ENST00000373025PGA3chr11

60971741

+PGCchr6

41705566

-
intron-intronENST00000538258ENST00000425343PGA3chr11

60971741

+PGCchr6

41705566

-
In-frameENST00000325558ENST00000373025PGA3chr11

60974099

+PGCchr6

41711127

-
In-frameENST00000325558ENST00000425343PGA3chr11

60974099

+PGCchr6

41711127

-
intron-3CDSENST00000543125ENST00000373025PGA3chr11

60974099

+PGCchr6

41711127

-
intron-3CDSENST00000543125ENST00000425343PGA3chr11

60974099

+PGCchr6

41711127

-
intron-3CDSENST00000538258ENST00000373025PGA3chr11

60974099

+PGCchr6

41711127

-
intron-3CDSENST00000538258ENST00000425343PGA3chr11

60974099

+PGCchr6

41711127

-
In-frameENST00000325558ENST00000373025PGA3chr11

60971741

+PGCchr6

41712252

-
In-frameENST00000325558ENST00000425343PGA3chr11

60971741

+PGCchr6

41712252

-
intron-3CDSENST00000543125ENST00000373025PGA3chr11

60971741

+PGCchr6

41712252

-
intron-3CDSENST00000543125ENST00000425343PGA3chr11

60971741

+PGCchr6

41712252

-
intron-3CDSENST00000538258ENST00000373025PGA3chr11

60971741

+PGCchr6

41712252

-
intron-3CDSENST00000538258ENST00000425343PGA3chr11

60971741

+PGCchr6

41712252

-
Frame-shiftENST00000325558ENST00000373025PGA3chr11

60974099

+PGCchr6

41712252

-
Frame-shiftENST00000325558ENST00000425343PGA3chr11

60974099

+PGCchr6

41712252

-
intron-3CDSENST00000543125ENST00000373025PGA3chr11

60974099

+PGCchr6

41712252

-
intron-3CDSENST00000543125ENST00000425343PGA3chr11

60974099

+PGCchr6

41712252

-
intron-3CDSENST00000538258ENST00000373025PGA3chr11

60974099

+PGCchr6

41712252

-
intron-3CDSENST00000538258ENST00000425343PGA3chr11

60974099

+PGCchr6

41712252

-
In-frameENST00000325558ENST00000373025PGA3chr11

60975962

+PGCchr6

41708348

-
5CDS-intronENST00000325558ENST00000425343PGA3chr11

60975962

+PGCchr6

41708348

-
intron-3CDSENST00000543125ENST00000373025PGA3chr11

60975962

+PGCchr6

41708348

-
intron-intronENST00000543125ENST00000425343PGA3chr11

60975962

+PGCchr6

41708348

-
intron-3CDSENST00000538258ENST00000373025PGA3chr11

60975962

+PGCchr6

41708348

-
intron-intronENST00000538258ENST00000425343PGA3chr11

60975962

+PGCchr6

41708348

-
Frame-shiftENST00000325558ENST00000373025PGA3chr11

60978907

+PGCchr6

41704742

-
5CDS-intronENST00000325558ENST00000425343PGA3chr11

60978907

+PGCchr6

41704742

-
Frame-shiftENST00000543125ENST00000373025PGA3chr11

60978907

+PGCchr6

41704742

-
5CDS-intronENST00000543125ENST00000425343PGA3chr11

60978907

+PGCchr6

41704742

-
Frame-shiftENST00000538258ENST00000373025PGA3chr11

60978907

+PGCchr6

41704742

-
5CDS-intronENST00000538258ENST00000425343PGA3chr11

60978907

+PGCchr6

41704742

-
Frame-shiftENST00000325558ENST00000373025PGA3chr11

60978907

+PGCchr6

41711127

-
Frame-shiftENST00000325558ENST00000425343PGA3chr11

60978907

+PGCchr6

41711127

-
Frame-shiftENST00000543125ENST00000373025PGA3chr11

60978907

+PGCchr6

41711127

-
Frame-shiftENST00000543125ENST00000425343PGA3chr11

60978907

+PGCchr6

41711127

-
Frame-shiftENST00000538258ENST00000373025PGA3chr11

60978907

+PGCchr6

41711127

-
Frame-shiftENST00000538258ENST00000425343PGA3chr11

60978907

+PGCchr6

41711127

-
intron-3CDSENST00000325558ENST00000373025PGA3chr11

60997445

+PGCchr6

41707626

-
intron-intronENST00000325558ENST00000425343PGA3chr11

60997445

+PGCchr6

41707626

-
intron-3CDSENST00000543125ENST00000373025PGA3chr11

60997445

+PGCchr6

41707626

-
intron-intronENST00000543125ENST00000425343PGA3chr11

60997445

+PGCchr6

41707626

-
intron-3CDSENST00000538258ENST00000373025PGA3chr11

60997445

+PGCchr6

41707626

-
intron-intronENST00000538258ENST00000425343PGA3chr11

60997445

+PGCchr6

41707626

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000325558PGA3chr1160971741+ENST00000373025PGCchr641705566-79740456232176
ENST00000325558PGA3chr1160974099+ENST00000373025PGCchr641711127-15025221311360409
ENST00000325558PGA3chr1160974099+ENST00000425343PGCchr641711127-12795221311141336
ENST00000325558PGA3chr1160971741+ENST00000373025PGCchr641712252-1502404126732411
ENST00000325558PGA3chr1160971741+ENST00000425343PGCchr641712252-12794041311141336
ENST00000325558PGA3chr1160975962+ENST00000373025PGCchr641708348-15028411311360409

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000325558ENST00000373025PGA3chr1160971741+PGCchr641705566-0.0271894930.9728105
ENST00000325558ENST00000373025PGA3chr1160974099+PGCchr641711127-0.0070719470.9929281
ENST00000325558ENST00000425343PGA3chr1160974099+PGCchr641711127-0.041793590.95820636
ENST00000325558ENST00000373025PGA3chr1160971741+PGCchr641712252-0.0083839250.9916161
ENST00000325558ENST00000425343PGA3chr1160971741+PGCchr641712252-0.0415520220.958448
ENST00000325558ENST00000373025PGA3chr1160975962+PGCchr641708348-0.0055300780.9944699

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Fusion Genomic Features for PGA3-PGC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGA3-PGC


check button Go to

FGviewer for the breakpoints of chr11:60971741-chr6:41705566

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PGC

PERM1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.790

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePGCchr11:60971741chr6:41705566ENST000004253430773_3850316.0DomainPeptidase A1
TgenePGCchr11:60971741chr6:41712252ENST000003730251973_38570.0389.0DomainPeptidase A1
TgenePGCchr11:60971741chr6:41712252ENST000004253431773_38570.0316.0DomainPeptidase A1
TgenePGCchr11:60975962chr6:41708348ENST000004253430773_3850316.0DomainPeptidase A1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGA3chr11:60971741chr6:41705566ENST00000325558+2976_38573.0389.0DomainPeptidase A1
HgenePGA3chr11:60971741chr6:41712252ENST00000325558+2976_38573.0389.0DomainPeptidase A1
HgenePGA3chr11:60974099chr6:41711127ENST00000325558+3976_385112.33333333333333389.0DomainPeptidase A1
HgenePGA3chr11:60975962chr6:41708348ENST00000325558+5976_385218.66666666666666389.0DomainPeptidase A1
TgenePGCchr11:60971741chr6:41705566ENST000003730256973_385305.0389.0DomainPeptidase A1
TgenePGCchr11:60974099chr6:41711127ENST000003730252973_385109.33333333333333389.0DomainPeptidase A1
TgenePGCchr11:60974099chr6:41711127ENST000004253432773_385109.33333333333333316.0DomainPeptidase A1
TgenePGCchr11:60975962chr6:41708348ENST000003730254973_385215.66666666666666389.0DomainPeptidase A1


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Fusion Gene Sequence for PGA3-PGC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000325558_ENST00000373025_TCGA-L5-A43C-11A_PGA3_chr11_60971741_+_PGC_chr6_41705566_length(transcript)=797nt_BP=404nt
TCAGAATGTGGCTTAGGGCAGCCACAATCTTATCAGGAGCTTCTCTGTTTGGGATCAGGGGAACCGGTGACTTTCAGAGGCCGATAAGGC
GGGACCCAACTTGTATATAAGGGGCAGCTCATGCTGCTGCTCTGCACCTTCCTCCCGTCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAA
GAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCACTCTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGA
GGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGAAGG
CTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATTTTCTCGTGAACTGTAACAGCATTCAGAATCTGCCCAGCTTGACCT
TCATCATCAATGGTGTGGAGTTCCCTCTGCCACCTTCCTCCTATATCCTCAGTAACAACGGCTACTGCACCGTGGGAGTCGAGCCCACCT
ACCTGTCCTCCCAGAACGGCCAGCCCCTGTGGATCCTCGGGGATGTCTTCCTCAGGTCCTACTATTCCGTCTACGACTTGGGCAACAACA
GAGTAGGCTTTGCCACTGCCGCCTAGACTTGCTGCCTCGACACGTGGGCTCCCCTCTTCCTCTTGACCCTGCACCCTCCTAGGGCATTGT

>In-frame_ENST00000325558_ENST00000373025_TCGA-L5-A43C-11A_PGA3_chr11_60971741_+_PGC_chr6_41705566_length(amino acids)=176AA_start in transcript=562_stop in transcript=32
MAVLGGQVGGLDSHGAVAVVTEDIGGRWQRELHTIDDEGQAGQILNAVTVHEKIQVVLQGLFIYQGGSLPLGEVLSGWVEVVLLQEVLQQ

--------------------------------------------------------------
>In-frame_ENST00000325558_ENST00000373025_TCGA-L5-A43C-11A_PGA3_chr11_60974099_+_PGC_chr6_41711127_length(transcript)=1502nt_BP=522nt
TCAGAATGTGGCTTAGGGCAGCCACAATCTTATCAGGAGCTTCTCTGTTTGGGATCAGGGGAACCGGTGACTTTCAGAGGCCGATAAGGC
GGGACCCAACTTGTATATAAGGGGCAGCTCATGCTGCTGCTCTGCACCTTCCTCCCGTCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAA
GAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCACTCTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGA
GGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGAAGG
CTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATATGGAGTACTTCGGCACTATCGGCATCGGAACTCCTGCCCAGGATT
TCACCGTCGTCTTTGACACCGGCTCCTCCAACCTGTGGGTGCCCTCAGTCTACTGCTCCAGTCTTGCCTGCACCAGTCACTCCCGCTTCA
ACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACCTTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATG
ACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCAGGAGTTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGT
TTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTCCGTGGATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCA
CCAGCCCCGTCTTCAGCGTCTACCTCAGCAACCAGCAGGGCTCCAGCGGGGGAGCGGTTGTCTTTGGGGGTGTGGATAGCAGCCTGTACA
CGGGGCAGATCTACTGGGCGCCTGTCACCCAGGAACTCTACTGGCAGATTGGCATTGAAGAGTTCCTCATCGGCGGCCAGGCCTCCGGCT
GGTGTTCTGAGGGTTGCCAGGCCATCGTGGACACAGGCACCTCTCTGCTCACTGTGCCCCAGCAGTACATGAGTGCTCTTCTGCAGGCCA
CAGGGGCCCAGGAGGATGAGTATGGACAGTTTCTCGTGAACTGTAACAGCATTCAGAATCTGCCCAGCTTGACCTTCATCATCAATGGTG
TGGAGTTCCCTCTGCCACCTTCCTCCTATATCCTCAGTAACAACGGCTACTGCACCGTGGGAGTCGAGCCCACCTACCTGTCCTCCCAGA
ACGGCCAGCCCCTGTGGATCCTCGGGGATGTCTTCCTCAGGTCCTACTATTCCGTCTACGACTTGGGCAACAACAGAGTAGGCTTTGCCA
CTGCCGCCTAGACTTGCTGCCTCGACACGTGGGCTCCCCTCTTCCTCTTGACCCTGCACCCTCCTAGGGCATTGTATCTGTCTTTCCACT

>In-frame_ENST00000325558_ENST00000373025_TCGA-L5-A43C-11A_PGA3_chr11_60974099_+_PGC_chr6_41711127_length(amino acids)=409AA_start in transcript=131_stop in transcript=1360
MHLPPVLPSPSSWDPGRTMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLENYL
DMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQE
FGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELY
WQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSN

--------------------------------------------------------------
>In-frame_ENST00000325558_ENST00000425343_TCGA-L5-A43C-11A_PGA3_chr11_60974099_+_PGC_chr6_41711127_length(transcript)=1279nt_BP=522nt
TCAGAATGTGGCTTAGGGCAGCCACAATCTTATCAGGAGCTTCTCTGTTTGGGATCAGGGGAACCGGTGACTTTCAGAGGCCGATAAGGC
GGGACCCAACTTGTATATAAGGGGCAGCTCATGCTGCTGCTCTGCACCTTCCTCCCGTCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAA
GAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCACTCTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGA
GGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGAAGG
CTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATATGGAGTACTTCGGCACTATCGGCATCGGAACTCCTGCCCAGGATT
TCACCGTCGTCTTTGACACCGGCTCCTCCAACCTGTGGGTGCCCTCAGTCTACTGCTCCAGTCTTGCCTGCACCAGTCACTCCCGCTTCA
ACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACCTTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATG
ACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCAGGAGTTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGT
TTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTCCGTGGATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCA
CCAGCCCCGTCTTCAGCGTCTACCTCAGCAACCTGGTCCTGGAGTCTTCTGGTCTAGGTCCACTGCTGACCCCTAGCAGAGCAGCTCCAC
CCAGCTCCACACTCCAGCTACCAGAGAAGCCTCTGGAACAAACATGGAATATCCTTACCCCCTTCACCAAGACCCTACCTGTCTCCAATC
TCAGCAGAAAAGTAACAAGCTGGGCCGGGGTGGGGATCCCGGTGACATGTCTACCAGAGGCAGGAAGCGGAGGGGAGAGGAGAGCAGAGT
GTGGGCTGGGGGTCCCAACCACTAGGGGACCCCCCAGAAGTCAGCATCATTCGGGAGCCTGAGGCGCTGGGAATTCCAAGGCCTGGCCAG
AAAGCCCCAGTCTAAGGGACGCATCCCAGTCCCCAGGGAGCCCCAATCTAAGGGATACAGCCCCATCCTCAGGGAGCCCCAGTCTGAGGG

>In-frame_ENST00000325558_ENST00000425343_TCGA-L5-A43C-11A_PGA3_chr11_60974099_+_PGC_chr6_41711127_length(amino acids)=336AA_start in transcript=131_stop in transcript=1141
MHLPPVLPSPSSWDPGRTMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLENYL
DMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQE
FGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNLVLESSGLGPLLTPSRAAPPSSTLQLPEKPLEQ

--------------------------------------------------------------
>In-frame_ENST00000325558_ENST00000373025_TCGA-L5-A43C-11A_PGA3_chr11_60971741_+_PGC_chr6_41712252_length(transcript)=1502nt_BP=404nt
TCAGAATGTGGCTTAGGGCAGCCACAATCTTATCAGGAGCTTCTCTGTTTGGGATCAGGGGAACCGGTGACTTTCAGAGGCCGATAAGGC
GGGACCCAACTTGTATATAAGGGGCAGCTCATGCTGCTGCTCTGCACCTTCCTCCCGTCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAA
GAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCACTCTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGA
GGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGAAGG
CTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACT
TCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTGCCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCA
ACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACCTTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATG
ACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCAGGAGTTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGT
TTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTCCGTGGATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCA
CCAGCCCCGTCTTCAGCGTCTACCTCAGCAACCAGCAGGGCTCCAGCGGGGGAGCGGTTGTCTTTGGGGGTGTGGATAGCAGCCTGTACA
CGGGGCAGATCTACTGGGCGCCTGTCACCCAGGAACTCTACTGGCAGATTGGCATTGAAGAGTTCCTCATCGGCGGCCAGGCCTCCGGCT
GGTGTTCTGAGGGTTGCCAGGCCATCGTGGACACAGGCACCTCTCTGCTCACTGTGCCCCAGCAGTACATGAGTGCTCTTCTGCAGGCCA
CAGGGGCCCAGGAGGATGAGTATGGACAGTTTCTCGTGAACTGTAACAGCATTCAGAATCTGCCCAGCTTGACCTTCATCATCAATGGTG
TGGAGTTCCCTCTGCCACCTTCCTCCTATATCCTCAGTAACAACGGCTACTGCACCGTGGGAGTCGAGCCCACCTACCTGTCCTCCCAGA
ACGGCCAGCCCCTGTGGATCCTCGGGGATGTCTTCCTCAGGTCCTACTATTCCGTCTACGACTTGGGCAACAACAGAGTAGGCTTTGCCA
CTGCCGCCTAGACTTGCTGCCTCGACACGTGGGCTCCCCTCTTCCTCTTGACCCTGCACCCTCCTAGGGCATTGTATCTGTCTTTCCACT

>In-frame_ENST00000325558_ENST00000373025_TCGA-L5-A43C-11A_PGA3_chr11_60971741_+_PGC_chr6_41712252_length(amino acids)=411AA_start in transcript=1267_stop in transcript=32
MAVLGGQVGGLDSHGAVAVVTEDIGGRWQRELHTIDDEGQAGQILNAVTVHEKLSILILLGPCGLQKSTHVLLGHSEQRGACVHDGLATL
RTPAGGLAADEELFNANLPVEFLGDRRPVDLPRVQAAIHTPKDNRSPAGALLVAEVDAEDGAGEGALLHHALHSCGGLIHGQSRVGQAHD
AIKLRIDEVGTRLILTQAELLVGDLDALDSQGVIAKEAGEAATAILQGEGLPIGGVGGRLAGVEAGVTGAGLALAVDRGHPQVGGAGVKK
DQEVLGWSPDADLTKVGSIQVVLQGLFIYQGGSLPLGEVLSGWVEVVLLQEVLQQATLGQGAPQGLLSDEGDLVHDALRECHQTQQQQPL

--------------------------------------------------------------
>In-frame_ENST00000325558_ENST00000425343_TCGA-L5-A43C-11A_PGA3_chr11_60971741_+_PGC_chr6_41712252_length(transcript)=1279nt_BP=404nt
TCAGAATGTGGCTTAGGGCAGCCACAATCTTATCAGGAGCTTCTCTGTTTGGGATCAGGGGAACCGGTGACTTTCAGAGGCCGATAAGGC
GGGACCCAACTTGTATATAAGGGGCAGCTCATGCTGCTGCTCTGCACCTTCCTCCCGTCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAA
GAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCACTCTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGA
GGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGAAGG
CTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACT
TCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTGCCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCA
ACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACCTTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATG
ACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCAGGAGTTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGT
TTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTCCGTGGATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCA
CCAGCCCCGTCTTCAGCGTCTACCTCAGCAACCTGGTCCTGGAGTCTTCTGGTCTAGGTCCACTGCTGACCCCTAGCAGAGCAGCTCCAC
CCAGCTCCACACTCCAGCTACCAGAGAAGCCTCTGGAACAAACATGGAATATCCTTACCCCCTTCACCAAGACCCTACCTGTCTCCAATC
TCAGCAGAAAAGTAACAAGCTGGGCCGGGGTGGGGATCCCGGTGACATGTCTACCAGAGGCAGGAAGCGGAGGGGAGAGGAGAGCAGAGT
GTGGGCTGGGGGTCCCAACCACTAGGGGACCCCCCAGAAGTCAGCATCATTCGGGAGCCTGAGGCGCTGGGAATTCCAAGGCCTGGCCAG
AAAGCCCCAGTCTAAGGGACGCATCCCAGTCCCCAGGGAGCCCCAATCTAAGGGATACAGCCCCATCCTCAGGGAGCCCCAGTCTGAGGG

>In-frame_ENST00000325558_ENST00000425343_TCGA-L5-A43C-11A_PGA3_chr11_60971741_+_PGC_chr6_41712252_length(amino acids)=336AA_start in transcript=131_stop in transcript=1141
MHLPPVLPSPSSWDPGRTMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLENYL
DAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQE
FGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNLVLESSGLGPLLTPSRAAPPSSTLQLPEKPLEQ

--------------------------------------------------------------
>In-frame_ENST00000325558_ENST00000373025_115Nd_PGA3_chr11_60975962_+_PGC_chr6_41708348_length(transcript)=1502nt_BP=841nt
TCAGAATGTGGCTTAGGGCAGCCACAATCTTATCAGGAGCTTCTCTGTTTGGGATCAGGGGAACCGGTGACTTTCAGAGGCCGATAAGGC
GGGACCCAACTTGTATATAAGGGGCAGCTCATGCTGCTGCTCTGCACCTTCCTCCCGTCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAA
GAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCACTCTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGA
GGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGAAGG
CTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATATGGAGTACTTCGGCACTATCGGCATCGGAACTCCTGCCCAGGATT
TCACCGTCGTCTTTGACACCGGCTCCTCCAACCTGTGGGTGCCCTCAGTCTACTGCTCCAGTCTTGCCTGCACCAACCACAACCGCTTCA
ACCCTGAGGATTCTTCCACCTACCAGTCCACCAGCGAGACAGTCTCCATCACCTACGGCACCGGCAGCATGACAGGCATCCTCGGATACG
ACACTGTCCAGGTTGGAGGCATCTCTGACACCAATCAGATCTTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCT
TCGATGGCATCCTGGGGCTGGCCTACCCCAGCATTTCCTCCTCCGGGGCCACACCCGTCTTTGACAACATCTGGAACCAGGGCCTGGTTT
CTCAGGACCTCTTCTCTGTCTACCTCAGCGCCCAGCAGGGCTCCAGCGGGGGAGCGGTTGTCTTTGGGGGTGTGGATAGCAGCCTGTACA
CGGGGCAGATCTACTGGGCGCCTGTCACCCAGGAACTCTACTGGCAGATTGGCATTGAAGAGTTCCTCATCGGCGGCCAGGCCTCCGGCT
GGTGTTCTGAGGGTTGCCAGGCCATCGTGGACACAGGCACCTCTCTGCTCACTGTGCCCCAGCAGTACATGAGTGCTCTTCTGCAGGCCA
CAGGGGCCCAGGAGGATGAGTATGGACAGTTTCTCGTGAACTGTAACAGCATTCAGAATCTGCCCAGCTTGACCTTCATCATCAATGGTG
TGGAGTTCCCTCTGCCACCTTCCTCCTATATCCTCAGTAACAACGGCTACTGCACCGTGGGAGTCGAGCCCACCTACCTGTCCTCCCAGA
ACGGCCAGCCCCTGTGGATCCTCGGGGATGTCTTCCTCAGGTCCTACTATTCCGTCTACGACTTGGGCAACAACAGAGTAGGCTTTGCCA
CTGCCGCCTAGACTTGCTGCCTCGACACGTGGGCTCCCCTCTTCCTCTTGACCCTGCACCCTCCTAGGGCATTGTATCTGTCTTTCCACT

>In-frame_ENST00000325558_ENST00000373025_115Nd_PGA3_chr11_60975962_+_PGC_chr6_41708348_length(amino acids)=409AA_start in transcript=131_stop in transcript=1360
MHLPPVLPSPSSWDPGRTMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLENYL
DMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQI
FGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSAQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELY
WQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PGA3-PGC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGA3-PGC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGA3-PGC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource