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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGA4-CAPN2 (FusionGDB2 ID:64103)

Fusion Gene Summary for PGA4-CAPN2

check button Fusion gene summary
Fusion gene informationFusion gene name: PGA4-CAPN2
Fusion gene ID: 64103
HgeneTgene
Gene symbol

PGA4

CAPN2

Gene ID

643847

824

Gene namepepsinogen A4calpain 2
Synonyms-CANP2|CANPL2|CANPml|mCANP
Cytomap

11q12.2

1q41

Type of geneprotein-codingprotein-coding
Descriptionpepsin A-4pepsinogen 4, group I (pepsinogen A)pepsinogen-4pregnancy-associated glycoproteincalpain-2 catalytic subunitCANP 2M-calpaincalcium-activated neutral proteinase 2calpain 2, (m/II) large subunitcalpain 2, large [catalytic] subunitcalpain 2, large subunitcalpain M-typecalpain, large polypeptide L2millimolar-calpain
Modification date2020031320200313
UniProtAcc.

P17655

Ensembl transtripts involved in fusion geneENST00000378149, ENST00000422676, 
ENST00000537932, ENST00000544899, 
ENST00000433674, ENST00000295006, 
ENST00000474026, 
Fusion gene scores* DoF score7 X 10 X 3=21011 X 7 X 7=539
# samples 911
** MAII scorelog2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/539*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGA4 [Title/Abstract] AND CAPN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGA4(60990577)-CAPN2(223946971), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAPN2

GO:0051603

proteolysis involved in cellular protein catabolic process

12150984


check buttonFusion gene breakpoints across PGA4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CAPN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer5357NPGA4chr11

60990577

+CAPN2chr1

223946971

+


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Fusion Gene ORF analysis for PGA4-CAPN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000378149ENST00000433674PGA4chr11

60990577

+CAPN2chr1

223946971

+
In-frameENST00000378149ENST00000295006PGA4chr11

60990577

+CAPN2chr1

223946971

+
5CDS-3UTRENST00000378149ENST00000474026PGA4chr11

60990577

+CAPN2chr1

223946971

+
In-frameENST00000422676ENST00000433674PGA4chr11

60990577

+CAPN2chr1

223946971

+
In-frameENST00000422676ENST00000295006PGA4chr11

60990577

+CAPN2chr1

223946971

+
5CDS-3UTRENST00000422676ENST00000474026PGA4chr11

60990577

+CAPN2chr1

223946971

+
intron-3CDSENST00000537932ENST00000433674PGA4chr11

60990577

+CAPN2chr1

223946971

+
intron-3CDSENST00000537932ENST00000295006PGA4chr11

60990577

+CAPN2chr1

223946971

+
intron-3UTRENST00000537932ENST00000474026PGA4chr11

60990577

+CAPN2chr1

223946971

+
intron-3CDSENST00000544899ENST00000433674PGA4chr11

60990577

+CAPN2chr1

223946971

+
intron-3CDSENST00000544899ENST00000295006PGA4chr11

60990577

+CAPN2chr1

223946971

+
intron-3UTRENST00000544899ENST00000474026PGA4chr11

60990577

+CAPN2chr1

223946971

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378149PGA4chr1160990577+ENST00000433674CAPN2chr1223946971+23494041311189352
ENST00000378149PGA4chr1160990577+ENST00000295006CAPN2chr1223946971+23514041311189352
ENST00000422676PGA4chr1160990577+ENST00000433674CAPN2chr1223946971+221927411059352
ENST00000422676PGA4chr1160990577+ENST00000295006CAPN2chr1223946971+222127411059352

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378149ENST00000433674PGA4chr1160990577+CAPN2chr1223946971+0.0003723960.9996276
ENST00000378149ENST00000295006PGA4chr1160990577+CAPN2chr1223946971+0.0003738340.99962616
ENST00000422676ENST00000433674PGA4chr1160990577+CAPN2chr1223946971+0.0003404090.99965954
ENST00000422676ENST00000295006PGA4chr1160990577+CAPN2chr1223946971+0.0003440240.99965596

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Fusion Genomic Features for PGA4-CAPN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PGA4chr1160990577+CAPN2chr1223946971+8.72E-121
PGA4chr1160990577+CAPN2chr1223946971+8.72E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PGA4-CAPN2


check button Go to

FGviewer for the breakpoints of chr11:60990577-chr1:223946971

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAPN2

P17655

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). {ECO:0000250|UniProtKB:O08529, ECO:0000269|PubMed:17650508}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCAPN2chr11:60990577chr1:223946971ENST000002950061021585_596439.0701.0Calcium bindingNote=1
TgeneCAPN2chr11:60990577chr1:223946971ENST000002950061021615_626439.0701.0Calcium bindingNote=2
TgeneCAPN2chr11:60990577chr1:223946971ENST000004336741021585_596361.0623.0Calcium bindingNote=1
TgeneCAPN2chr11:60990577chr1:223946971ENST000004336741021615_626361.0623.0Calcium bindingNote=2
TgeneCAPN2chr11:60990577chr1:223946971ENST000002950061021572_605439.0701.0DomainEF-hand 1
TgeneCAPN2chr11:60990577chr1:223946971ENST000002950061021602_637439.0701.0DomainEF-hand 2
TgeneCAPN2chr11:60990577chr1:223946971ENST000002950061021667_700439.0701.0DomainEF-hand 3
TgeneCAPN2chr11:60990577chr1:223946971ENST000004336741021572_605361.0623.0DomainEF-hand 1
TgeneCAPN2chr11:60990577chr1:223946971ENST000004336741021602_637361.0623.0DomainEF-hand 2
TgeneCAPN2chr11:60990577chr1:223946971ENST000004336741021667_700361.0623.0DomainEF-hand 3
TgeneCAPN2chr11:60990577chr1:223946971ENST000002950061021515_529439.0701.0RegionNote=Linker
TgeneCAPN2chr11:60990577chr1:223946971ENST000002950061021530_700439.0701.0RegionNote=Domain IV
TgeneCAPN2chr11:60990577chr1:223946971ENST000004336741021515_529361.0623.0RegionNote=Linker
TgeneCAPN2chr11:60990577chr1:223946971ENST000004336741021530_700361.0623.0RegionNote=Domain IV

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGA4chr11:60990577chr1:223946971ENST00000378149+2976_38573.0389.0DomainPeptidase A1
TgeneCAPN2chr11:60990577chr1:223946971ENST00000295006102145_344439.0701.0DomainCalpain catalytic
TgeneCAPN2chr11:60990577chr1:223946971ENST00000433674102145_344361.0623.0DomainCalpain catalytic
TgeneCAPN2chr11:60990577chr1:223946971ENST000002950061021345_514439.0701.0RegionNote=Domain III
TgeneCAPN2chr11:60990577chr1:223946971ENST000004336741021345_514361.0623.0RegionNote=Domain III


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Fusion Gene Sequence for PGA4-CAPN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000378149_ENST00000433674_5357N_PGA4_chr11_60990577_+_CAPN2_chr1_223946971_length(transcript)=2349nt_BP=404nt
TCAGAATGTGGCTCAGGGCAGCCACAATCTTATCAGGAGCTTCTCTGTTTGGGATCAGGGGAACCGGTGACTTTCAGAGGCCGATAAGGC
GGGACCCAACTTGTATATAAGGGGCAGCTCATGCTGCTGCTCTGCACCTTCCTCCCATCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAA
GAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCGCTCTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGA
GGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGGAGG
CTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATTTAAGTGGGCAGACCAACATCCACCTCAGCAAAAACTTCTTCCTGA
CGAATCGCGCCAGGGAGCGCTCAGACACCTTCATCAACCTCCGGGAGGTGCTCAACCGCTTCAAGCTGCCGCCAGGAGAGTACATTCTCG
TGCCTTCCACCTTCGAACCCAACAAGGATGGGGATTTCTGCATCCGGGTCTTTTCTGAAAAGAAAGCTGACTACCAAGCTGTCGATGATG
AAATCGAGGCCAATCTTGAAGAGTTCGACATCAGCGAGGATGACATTGATGATGGATTCAGGAGACTGTTTGCCCAGTTGGCAGGAGAGG
ATGCGGAGATCTCTGCCTTTGAGCTGCAGACCATCCTGAGAAGGGTTCTAGCAAAGCGCCAAGATATCAAGTCAGATGGCTTCAGCATCG
AGACATGCAAAATTATGGTTGACATGCTAGATTCGGACGGGAGTGGCAAGCTGGGGCTGAAGGAGTTCTACATTCTCTGGACGAAGATTC
AAAAATACCAAAAAATTTACCGAGAAATCGACGTTGACAGGTCTGGTACCATGAATTCCTATGAAATGCGGAAGGCATTAGAAGAAGCAG
GTTTCAAGATGCCCTGTCAACTCCACCAAGTCATCGTTGCTCGGTTTGCAGATGACCAGCTCATCATCGATTTTGATAATTTTGTTCGGT
GTTTGGTTCGGCTGGAAACGCTATTCAAGATATTTAAGCAGCTGGATCCCGAGAATACTGGAACAATAGAGCTCGACCTTATCTCTTGGC
TCTGTTTCTCAGTACTTTGAAGTTATAACTAATCTGCCTGAAGACTTCTCATGATGGAAAATCAGCCAAGGACTAAGCTTCCATAGAAAT
ACACTTTGTATCTGGACCTCAAAATTATGGGAACATTTACTTAAACGGATGATCATAGCTGAAAATAATGATACTGTCAATTTGAGATAG
CAGAAGTTTCACACATCAAAGTAAAAGATTTGCATATCATTATACTAAATGCAAATGAGTCGCTTAACCCTTGACAAGGTCAAAGAAAGC
TTTAAATCTGTAAATAGTATACACTTTTTACTTTTACACACTTTCCTGTTCATAGCAATATTAAATCAGGAAAAAAAAATGCAGGGAGGT
ATTTAACAGCTGAGCAAAAACATTGAGTCGCTCTCAAAGGACACGAGGCCCTTGGCAGGGAATATTTAAAGCAACTTCAAGTTTAAAATG
CAGCTGTTGATTCTACCAAACAACAGTCCAAGATTACCATTTCCCATGAGCCAACTGGGAAACATGGTATATCATGAAGTAATCTTGTCA
AGGCATCTGGAGAGTCCAGGAGAGAAGACTCACCTCTGTCGCTTGGGTTAAACAAGAGACAGGTTTTGTAGAATATTGATTGGTAATAGT
AAATCGTTCTCCTTACAATCAAGTTCTTGACCCTATTCGGCCTTATACATCTGGTCTTACAAAGACCAAAGGGATCCTGCGCTTGATCAA
CTGAACCAGTATGCCAAAACCAGGCATCCAATTTGTAAACCAATTATGATAAAGGACAAAATAAGCTGTTTGCCACCTCAAAACTTTATG
AACTTCACCACCACTAGTGTCTGTCCATGGAGTTAGAGGGGACATCACTTAGAAGTTCTTATAGAAAGGACACAAGTTTGTTTCCTGGCT
TTACCTTGGGAAAATGCTAGCAACATTATAGAAATTTTGCCTTGTTGCCTTATCTTCTTCCAAATGTACTGTTAAATAAAAATAAAGGGT
TACCCCATGCAATCACACCATGCCATGTTTTCCTTCCTGGAGGGCAGCCCCACAGGACGGTTTATGAGCACACAATTATAGCTTGTTTCT
ACTTTAACAAGGTATGCTGCCTCTGTAAATTCATGTATTCAAAGGAAAAGACACCTTGCCTATAATTAAAATGTGGAACTATAAAATTTT

>In-frame_ENST00000378149_ENST00000433674_5357N_PGA4_chr11_60990577_+_CAPN2_chr1_223946971_length(amino acids)=352AA_start in transcript=131_stop in transcript=1189
MHLPPILPSPSSWDPGRTMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVDEQPLENYL
DLSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISED
DIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR

--------------------------------------------------------------
>In-frame_ENST00000378149_ENST00000295006_5357N_PGA4_chr11_60990577_+_CAPN2_chr1_223946971_length(transcript)=2351nt_BP=404nt
TCAGAATGTGGCTCAGGGCAGCCACAATCTTATCAGGAGCTTCTCTGTTTGGGATCAGGGGAACCGGTGACTTTCAGAGGCCGATAAGGC
GGGACCCAACTTGTATATAAGGGGCAGCTCATGCTGCTGCTCTGCACCTTCCTCCCATCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAA
GAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCGCTCTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGA
GGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGGAGG
CTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATTTAAGTGGGCAGACCAACATCCACCTCAGCAAAAACTTCTTCCTGA
CGAATCGCGCCAGGGAGCGCTCAGACACCTTCATCAACCTCCGGGAGGTGCTCAACCGCTTCAAGCTGCCGCCAGGAGAGTACATTCTCG
TGCCTTCCACCTTCGAACCCAACAAGGATGGGGATTTCTGCATCCGGGTCTTTTCTGAAAAGAAAGCTGACTACCAAGCTGTCGATGATG
AAATCGAGGCCAATCTTGAAGAGTTCGACATCAGCGAGGATGACATTGATGATGGATTCAGGAGACTGTTTGCCCAGTTGGCAGGAGAGG
ATGCGGAGATCTCTGCCTTTGAGCTGCAGACCATCCTGAGAAGGGTTCTAGCAAAGCGCCAAGATATCAAGTCAGATGGCTTCAGCATCG
AGACATGCAAAATTATGGTTGACATGCTAGATTCGGACGGGAGTGGCAAGCTGGGGCTGAAGGAGTTCTACATTCTCTGGACGAAGATTC
AAAAATACCAAAAAATTTACCGAGAAATCGACGTTGACAGGTCTGGTACCATGAATTCCTATGAAATGCGGAAGGCATTAGAAGAAGCAG
GTTTCAAGATGCCCTGTCAACTCCACCAAGTCATCGTTGCTCGGTTTGCAGATGACCAGCTCATCATCGATTTTGATAATTTTGTTCGGT
GTTTGGTTCGGCTGGAAACGCTATTCAAGATATTTAAGCAGCTGGATCCCGAGAATACTGGAACAATAGAGCTCGACCTTATCTCTTGGC
TCTGTTTCTCAGTACTTTGAAGTTATAACTAATCTGCCTGAAGACTTCTCATGATGGAAAATCAGCCAAGGACTAAGCTTCCATAGAAAT
ACACTTTGTATCTGGACCTCAAAATTATGGGAACATTTACTTAAACGGATGATCATAGCTGAAAATAATGATACTGTCAATTTGAGATAG
CAGAAGTTTCACACATCAAAGTAAAAGATTTGCATATCATTATACTAAATGCAAATGAGTCGCTTAACCCTTGACAAGGTCAAAGAAAGC
TTTAAATCTGTAAATAGTATACACTTTTTACTTTTACACACTTTCCTGTTCATAGCAATATTAAATCAGGAAAAAAAAATGCAGGGAGGT
ATTTAACAGCTGAGCAAAAACATTGAGTCGCTCTCAAAGGACACGAGGCCCTTGGCAGGGAATATTTAAAGCAACTTCAAGTTTAAAATG
CAGCTGTTGATTCTACCAAACAACAGTCCAAGATTACCATTTCCCATGAGCCAACTGGGAAACATGGTATATCATGAAGTAATCTTGTCA
AGGCATCTGGAGAGTCCAGGAGAGAAGACTCACCTCTGTCGCTTGGGTTAAACAAGAGACAGGTTTTGTAGAATATTGATTGGTAATAGT
AAATCGTTCTCCTTACAATCAAGTTCTTGACCCTATTCGGCCTTATACATCTGGTCTTACAAAGACCAAAGGGATCCTGCGCTTGATCAA
CTGAACCAGTATGCCAAAACCAGGCATCCAATTTGTAAACCAATTATGATAAAGGACAAAATAAGCTGTTTGCCACCTCAAAACTTTATG
AACTTCACCACCACTAGTGTCTGTCCATGGAGTTAGAGGGGACATCACTTAGAAGTTCTTATAGAAAGGACACAAGTTTGTTTCCTGGCT
TTACCTTGGGAAAATGCTAGCAACATTATAGAAATTTTGCCTTGTTGCCTTATCTTCTTCCAAATGTACTGTTAAATAAAAATAAAGGGT
TACCCCATGCAATCACACCATGCCATGTTTTCCTTCCTGGAGGGCAGCCCCACAGGACGGTTTATGAGCACACAATTATAGCTTGTTTCT
ACTTTAACAAGGTATGCTGCCTCTGTAAATTCATGTATTCAAAGGAAAAGACACCTTGCCTATAATTAAAATGTGGAACTATAAAATTTT

>In-frame_ENST00000378149_ENST00000295006_5357N_PGA4_chr11_60990577_+_CAPN2_chr1_223946971_length(amino acids)=352AA_start in transcript=131_stop in transcript=1189
MHLPPILPSPSSWDPGRTMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVDEQPLENYL
DLSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISED
DIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR

--------------------------------------------------------------
>In-frame_ENST00000422676_ENST00000433674_5357N_PGA4_chr11_60990577_+_CAPN2_chr1_223946971_length(transcript)=2219nt_BP=274nt
TCTGCACCTTCCTCCCATCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAAGAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCGCT
CTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGAGGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCT
GAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGGAGGCTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCT
GGATTTAAGTGGGCAGACCAACATCCACCTCAGCAAAAACTTCTTCCTGACGAATCGCGCCAGGGAGCGCTCAGACACCTTCATCAACCT
CCGGGAGGTGCTCAACCGCTTCAAGCTGCCGCCAGGAGAGTACATTCTCGTGCCTTCCACCTTCGAACCCAACAAGGATGGGGATTTCTG
CATCCGGGTCTTTTCTGAAAAGAAAGCTGACTACCAAGCTGTCGATGATGAAATCGAGGCCAATCTTGAAGAGTTCGACATCAGCGAGGA
TGACATTGATGATGGATTCAGGAGACTGTTTGCCCAGTTGGCAGGAGAGGATGCGGAGATCTCTGCCTTTGAGCTGCAGACCATCCTGAG
AAGGGTTCTAGCAAAGCGCCAAGATATCAAGTCAGATGGCTTCAGCATCGAGACATGCAAAATTATGGTTGACATGCTAGATTCGGACGG
GAGTGGCAAGCTGGGGCTGAAGGAGTTCTACATTCTCTGGACGAAGATTCAAAAATACCAAAAAATTTACCGAGAAATCGACGTTGACAG
GTCTGGTACCATGAATTCCTATGAAATGCGGAAGGCATTAGAAGAAGCAGGTTTCAAGATGCCCTGTCAACTCCACCAAGTCATCGTTGC
TCGGTTTGCAGATGACCAGCTCATCATCGATTTTGATAATTTTGTTCGGTGTTTGGTTCGGCTGGAAACGCTATTCAAGATATTTAAGCA
GCTGGATCCCGAGAATACTGGAACAATAGAGCTCGACCTTATCTCTTGGCTCTGTTTCTCAGTACTTTGAAGTTATAACTAATCTGCCTG
AAGACTTCTCATGATGGAAAATCAGCCAAGGACTAAGCTTCCATAGAAATACACTTTGTATCTGGACCTCAAAATTATGGGAACATTTAC
TTAAACGGATGATCATAGCTGAAAATAATGATACTGTCAATTTGAGATAGCAGAAGTTTCACACATCAAAGTAAAAGATTTGCATATCAT
TATACTAAATGCAAATGAGTCGCTTAACCCTTGACAAGGTCAAAGAAAGCTTTAAATCTGTAAATAGTATACACTTTTTACTTTTACACA
CTTTCCTGTTCATAGCAATATTAAATCAGGAAAAAAAAATGCAGGGAGGTATTTAACAGCTGAGCAAAAACATTGAGTCGCTCTCAAAGG
ACACGAGGCCCTTGGCAGGGAATATTTAAAGCAACTTCAAGTTTAAAATGCAGCTGTTGATTCTACCAAACAACAGTCCAAGATTACCAT
TTCCCATGAGCCAACTGGGAAACATGGTATATCATGAAGTAATCTTGTCAAGGCATCTGGAGAGTCCAGGAGAGAAGACTCACCTCTGTC
GCTTGGGTTAAACAAGAGACAGGTTTTGTAGAATATTGATTGGTAATAGTAAATCGTTCTCCTTACAATCAAGTTCTTGACCCTATTCGG
CCTTATACATCTGGTCTTACAAAGACCAAAGGGATCCTGCGCTTGATCAACTGAACCAGTATGCCAAAACCAGGCATCCAATTTGTAAAC
CAATTATGATAAAGGACAAAATAAGCTGTTTGCCACCTCAAAACTTTATGAACTTCACCACCACTAGTGTCTGTCCATGGAGTTAGAGGG
GACATCACTTAGAAGTTCTTATAGAAAGGACACAAGTTTGTTTCCTGGCTTTACCTTGGGAAAATGCTAGCAACATTATAGAAATTTTGC
CTTGTTGCCTTATCTTCTTCCAAATGTACTGTTAAATAAAAATAAAGGGTTACCCCATGCAATCACACCATGCCATGTTTTCCTTCCTGG
AGGGCAGCCCCACAGGACGGTTTATGAGCACACAATTATAGCTTGTTTCTACTTTAACAAGGTATGCTGCCTCTGTAAATTCATGTATTC

>In-frame_ENST00000422676_ENST00000433674_5357N_PGA4_chr11_60990577_+_CAPN2_chr1_223946971_length(amino acids)=352AA_start in transcript=1_stop in transcript=1059
LHLPPILPSPSSWDPGRTMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVDEQPLENYL
DLSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISED
DIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR

--------------------------------------------------------------
>In-frame_ENST00000422676_ENST00000295006_5357N_PGA4_chr11_60990577_+_CAPN2_chr1_223946971_length(transcript)=2221nt_BP=274nt
TCTGCACCTTCCTCCCATCTTGCCTTCTCCCTCGAGTTGGGACCCGGGAAGAACCATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCGCT
CTCTGAGTGCATCATGTACAAGGTCCCCCTCATCAGAAAGAAGTCCTTGAGGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGACTTCCT
GAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGGAGGCTCCCACCCTGGTAGATGAACAGCCCCTGGAGAACTACCT
GGATTTAAGTGGGCAGACCAACATCCACCTCAGCAAAAACTTCTTCCTGACGAATCGCGCCAGGGAGCGCTCAGACACCTTCATCAACCT
CCGGGAGGTGCTCAACCGCTTCAAGCTGCCGCCAGGAGAGTACATTCTCGTGCCTTCCACCTTCGAACCCAACAAGGATGGGGATTTCTG
CATCCGGGTCTTTTCTGAAAAGAAAGCTGACTACCAAGCTGTCGATGATGAAATCGAGGCCAATCTTGAAGAGTTCGACATCAGCGAGGA
TGACATTGATGATGGATTCAGGAGACTGTTTGCCCAGTTGGCAGGAGAGGATGCGGAGATCTCTGCCTTTGAGCTGCAGACCATCCTGAG
AAGGGTTCTAGCAAAGCGCCAAGATATCAAGTCAGATGGCTTCAGCATCGAGACATGCAAAATTATGGTTGACATGCTAGATTCGGACGG
GAGTGGCAAGCTGGGGCTGAAGGAGTTCTACATTCTCTGGACGAAGATTCAAAAATACCAAAAAATTTACCGAGAAATCGACGTTGACAG
GTCTGGTACCATGAATTCCTATGAAATGCGGAAGGCATTAGAAGAAGCAGGTTTCAAGATGCCCTGTCAACTCCACCAAGTCATCGTTGC
TCGGTTTGCAGATGACCAGCTCATCATCGATTTTGATAATTTTGTTCGGTGTTTGGTTCGGCTGGAAACGCTATTCAAGATATTTAAGCA
GCTGGATCCCGAGAATACTGGAACAATAGAGCTCGACCTTATCTCTTGGCTCTGTTTCTCAGTACTTTGAAGTTATAACTAATCTGCCTG
AAGACTTCTCATGATGGAAAATCAGCCAAGGACTAAGCTTCCATAGAAATACACTTTGTATCTGGACCTCAAAATTATGGGAACATTTAC
TTAAACGGATGATCATAGCTGAAAATAATGATACTGTCAATTTGAGATAGCAGAAGTTTCACACATCAAAGTAAAAGATTTGCATATCAT
TATACTAAATGCAAATGAGTCGCTTAACCCTTGACAAGGTCAAAGAAAGCTTTAAATCTGTAAATAGTATACACTTTTTACTTTTACACA
CTTTCCTGTTCATAGCAATATTAAATCAGGAAAAAAAAATGCAGGGAGGTATTTAACAGCTGAGCAAAAACATTGAGTCGCTCTCAAAGG
ACACGAGGCCCTTGGCAGGGAATATTTAAAGCAACTTCAAGTTTAAAATGCAGCTGTTGATTCTACCAAACAACAGTCCAAGATTACCAT
TTCCCATGAGCCAACTGGGAAACATGGTATATCATGAAGTAATCTTGTCAAGGCATCTGGAGAGTCCAGGAGAGAAGACTCACCTCTGTC
GCTTGGGTTAAACAAGAGACAGGTTTTGTAGAATATTGATTGGTAATAGTAAATCGTTCTCCTTACAATCAAGTTCTTGACCCTATTCGG
CCTTATACATCTGGTCTTACAAAGACCAAAGGGATCCTGCGCTTGATCAACTGAACCAGTATGCCAAAACCAGGCATCCAATTTGTAAAC
CAATTATGATAAAGGACAAAATAAGCTGTTTGCCACCTCAAAACTTTATGAACTTCACCACCACTAGTGTCTGTCCATGGAGTTAGAGGG
GACATCACTTAGAAGTTCTTATAGAAAGGACACAAGTTTGTTTCCTGGCTTTACCTTGGGAAAATGCTAGCAACATTATAGAAATTTTGC
CTTGTTGCCTTATCTTCTTCCAAATGTACTGTTAAATAAAAATAAAGGGTTACCCCATGCAATCACACCATGCCATGTTTTCCTTCCTGG
AGGGCAGCCCCACAGGACGGTTTATGAGCACACAATTATAGCTTGTTTCTACTTTAACAAGGTATGCTGCCTCTGTAAATTCATGTATTC

>In-frame_ENST00000422676_ENST00000295006_5357N_PGA4_chr11_60990577_+_CAPN2_chr1_223946971_length(amino acids)=352AA_start in transcript=1_stop in transcript=1059
LHLPPILPSPSSWDPGRTMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVDEQPLENYL
DLSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISED
DIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR

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Fusion Gene PPI Analysis for PGA4-CAPN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGA4-CAPN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGA4-CAPN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCAPN2C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneCAPN2C0026998Acute Myeloid Leukemia, M11CTD_human
TgeneCAPN2C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human